Found 14 hits with Last Name = 'lopez-girona' and Initial = 'a' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50545275
(CHEMBL4645677)Show SMILES Fc1ccc(N2CCN(Cc3ccc(COc4cccc5C(=O)N(Cc45)C4CCC(=O)NC4=O)cc3)CC2)c(F)c1 Show InChI InChI=1S/C31H30F2N4O4/c32-22-8-9-26(25(33)16-22)36-14-12-35(13-15-36)17-20-4-6-21(7-5-20)19-41-28-3-1-2-23-24(28)18-37(31(23)40)27-10-11-29(38)34-30(27)39/h1-9,16,27H,10-15,17-19H2,(H,34,38,39) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description Inhibition of adrenergic receptor alpha1 (unknown origin) |
J Med Chem 63: 6648-6676 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01928 BindingDB Entry DOI: 10.7270/Q2KS6W4N |
More data for this Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50545276
(CHEMBL4637801)Show SMILES Fc1cc(ccc1N1CCN(Cc2ccc(COc3cccc4C(=O)N(Cc34)C3CCC(=O)NC3=O)cc2)CC1)C#N Show InChI InChI=1S/C32H30FN5O4/c33-26-16-23(17-34)8-9-27(26)37-14-12-36(13-15-37)18-21-4-6-22(7-5-21)20-42-29-3-1-2-24-25(29)19-38(32(24)41)28-10-11-30(39)35-31(28)40/h1-9,16,28H,10-15,18-20H2,(H,35,39,40) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
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PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 980 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description Inhibition of adrenergic receptor alpha1 (unknown origin) |
J Med Chem 63: 6648-6676 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01928 BindingDB Entry DOI: 10.7270/Q2KS6W4N |
More data for this Ligand-Target Pair | |
Cytochrome P450 2C19
(Homo sapiens (Human)) | BDBM50557457
(CHEMBL4742712)Show SMILES FC(F)(C(=O)NCc1ccc2C(=O)N(Cc2c1)C1CCC(=O)NC1=O)c1ccc(Cl)cc1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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MCE PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 1.53E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of CYP2C19 (unknown origin) |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01489 BindingDB Entry DOI: 10.7270/Q2F47STZ |
More data for this Ligand-Target Pair | |
Protein cereblon
(Homo sapiens (Human)) | BDBM65454
(191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...)Show InChI InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
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DrugBank MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene
| Assay Description To measure compound binding to endogenous CRBN. |
Leukemia 26: 2326-35 (2012)
Article DOI: 10.1038/leu.2012.119 BindingDB Entry DOI: 10.7270/Q26971RH |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Protein cereblon
(Homo sapiens (Human)) | BDBM65456
(19171-19-8 | 4-amino-2-(2,6-dioxopiperidin-3-yl)is...)Show InChI InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
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DrugBank MCE PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene
| Assay Description To measure compound binding to endogenous CRBN. |
Leukemia 26: 2326-35 (2012)
Article DOI: 10.1038/leu.2012.119 BindingDB Entry DOI: 10.7270/Q26971RH |
More data for this Ligand-Target Pair | |
DNA damage-binding protein 1/Protein cereblon
(Homo sapiens (Human)) | BDBM65456
(19171-19-8 | 4-amino-2-(2,6-dioxopiperidin-3-yl)is...)Show InChI InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
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DrugBank MCE PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | 8.0 | 70 |
Celgene
| Assay Description Thermal stabilities of CRBN-DDB1 in the presence or absence of phthalimide, thalidomide, lenalidomide and pomalidomide were done in the presence of S... |
Leukemia 26: 2326-35 (2012)
Article DOI: 10.1038/leu.2012.119 BindingDB Entry DOI: 10.7270/Q26971RH |
More data for this Ligand-Target Pair | |
DNA damage-binding protein 1/Protein cereblon
(Homo sapiens (Human)) | BDBM65454
(191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...)Show InChI InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
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DrugBank MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | 8.0 | 70 |
Celgene
| Assay Description Thermal stabilities of CRBN-DDB1 in the presence or absence of phthalimide, thalidomide, lenalidomide and pomalidomide were done in the presence of S... |
Leukemia 26: 2326-35 (2012)
Article DOI: 10.1038/leu.2012.119 BindingDB Entry DOI: 10.7270/Q26971RH |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50557457
(CHEMBL4742712)Show SMILES FC(F)(C(=O)NCc1ccc2C(=O)N(Cc2c1)C1CCC(=O)NC1=O)c1ccc(Cl)cc1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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MCE PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ERG |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01489 BindingDB Entry DOI: 10.7270/Q2F47STZ |
More data for this Ligand-Target Pair | |
Protein cereblon
(Homo sapiens (Human)) | BDBM65457
((-)-Thalidomide | (S)-Thalidomide)Show InChI InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)/t9-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
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MCE KEGG PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene
| Assay Description To measure compound binding to endogenous CRBN. |
Leukemia 26: 2326-35 (2012)
Article DOI: 10.1038/leu.2012.119 BindingDB Entry DOI: 10.7270/Q26971RH |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
DNA damage-binding protein 1
(Homo sapiens (Human)) | BDBM50070114
((+/-)-thalidomide | 2-(2,6-Dioxo-piperidin-3-yl)-i...)Show InChI InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | 8.0 | 70 |
Celgene
| Assay Description Thermal stabilities of CRBN-DDB1 in the presence or absence of phthalimide, thalidomide, lenalidomide and pomalidomide were done in the presence of S... |
Leukemia 26: 2326-35 (2012)
Article DOI: 10.1038/leu.2012.119 BindingDB Entry DOI: 10.7270/Q26971RH |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Protein cereblon
(Homo sapiens (Human)) | BDBM65362
((+)-Thalidomide | (R)-(+)-thalidomide | (R)-Thalid...)Show InChI InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)/t9-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
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MCE KEGG PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene
| Assay Description To measure compound binding to endogenous CRBN. |
Leukemia 26: 2326-35 (2012)
Article DOI: 10.1038/leu.2012.119 BindingDB Entry DOI: 10.7270/Q26971RH |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
DNA-binding protein Ikaros/Protein cereblon
(Homo sapiens (Human)) | BDBM50557457
(CHEMBL4742712)Show SMILES FC(F)(C(=O)NCc1ccc2C(=O)N(Cc2c1)C1CCC(=O)NC1=O)c1ccc(Cl)cc1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Protac activity at CRBN/IKZF1 (unknown origin) assessed as IKZF1 degradation |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01489 BindingDB Entry DOI: 10.7270/Q2F47STZ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50545275
(CHEMBL4645677)Show SMILES Fc1ccc(N2CCN(Cc3ccc(COc4cccc5C(=O)N(Cc45)C4CCC(=O)NC4=O)cc3)CC2)c(F)c1 Show InChI InChI=1S/C31H30F2N4O4/c32-22-8-9-26(25(33)16-22)36-14-12-35(13-15-36)17-20-4-6-21(7-5-20)19-41-28-3-1-2-23-24(28)18-37(31(23)40)27-10-11-29(38)34-30(27)39/h1-9,16,27H,10-15,17-19H2,(H,34,38,39) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 16 | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description Agonist activity at D2S (unknown origin) |
J Med Chem 63: 6648-6676 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01928 BindingDB Entry DOI: 10.7270/Q2KS6W4N |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50545276
(CHEMBL4637801)Show SMILES Fc1cc(ccc1N1CCN(Cc2ccc(COc3cccc4C(=O)N(Cc34)C3CCC(=O)NC3=O)cc2)CC1)C#N Show InChI InChI=1S/C32H30FN5O4/c33-26-16-23(17-34)8-9-27(26)37-14-12-36(13-15-37)18-21-4-6-22(7-5-21)20-42-29-3-1-2-24-25(29)19-38(32(24)41)28-10-11-30(39)35-31(28)40/h1-9,16,28H,10-15,18-20H2,(H,35,39,40) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description Agonist activity at D2S (unknown origin) |
J Med Chem 63: 6648-6676 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01928 BindingDB Entry DOI: 10.7270/Q2KS6W4N |
More data for this Ligand-Target Pair | |