| Reaction Details |
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 | Report a problem with these data |
| Target | D(2) dopamine receptor |
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| Ligand | BDBM50545276 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1994669 (CHEMBL4628564) |
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| EC50 | >10000±n/a nM |
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| Citation |  Hansen, JD; Correa, M; Nagy, MA; Alexander, M; Plantevin, V; Grant, V; Whitefield, B; Huang, D; Kercher, T; Harris, R; Narla, RK; Leisten, J; Tang, Y; Moghaddam, M; Ebinger, K; Piccotti, J; Havens, CG; Cathers, B; Carmichael, J; Daniel, T; Vessey, R; Hamann, LG; Leftheris, K; Mendy, D; Baculi, F; LeBrun, LA; Khambatta, G; Lopez-Girona, A Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma. J Med Chem63:6648-6676 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| D(2) dopamine receptor |
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| Name: | D(2) dopamine receptor |
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| Synonyms: | D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2 |
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| Type: | Cell-surface receptors |
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| Mol. Mass.: | 50647.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14416 |
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| Residue: | 443 |
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| Sequence: | MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
VNPIIYTTFNIEFRKAFLKILHC
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| BDBM50545276 |
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| n/a |
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| Name | BDBM50545276 |
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| Synonyms: | CHEMBL4637801 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H30FN5O4 |
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| Mol. Mass. | 567.6101 |
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| SMILES | Fc1cc(ccc1N1CCN(Cc2ccc(COc3cccc4C(=O)N(Cc34)C3CCC(=O)NC3=O)cc2)CC1)C#N |
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| Structure | 
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