BindingDB PrimarySearch

Found 11 hits with Last Name = 'mendy' and Initial = 'd'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Homo sapiens (Human))	BDBM50545275 (CHEMBL4645677) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Corporation Curated by ChEMBL					Assay Description Inhibition of adrenergic receptor alpha1 (unknown origin)				J Med Chem 63: 6648-6676 (2020) Article DOI: 10.1021/acs.jmedchem.9b01928 BindingDB Entry DOI: 10.7270/Q2KS6W4N
Celgene Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Homo sapiens (Human))	BDBM50545276 (CHEMBL4637801) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	980	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Corporation Curated by ChEMBL					Assay Description Inhibition of adrenergic receptor alpha1 (unknown origin)				J Med Chem 63: 6648-6676 (2020) Article DOI: 10.1021/acs.jmedchem.9b01928 BindingDB Entry DOI: 10.7270/Q2KS6W4N
Celgene Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Protein cereblon (Homo sapiens (Human))	BDBM65454 (191732-72-6 \| CC-5013 \| Lenalidomide \| Revimid \| R...) Show SMILES Nc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celgene					Assay Description To measure compound binding to endogenous CRBN.				Leukemia 26: 2326-35 (2012) Article DOI: 10.1038/leu.2012.119 BindingDB Entry DOI: 10.7270/Q26971RH
Celgene					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein cereblon (Homo sapiens (Human))	BDBM65456 (19171-19-8 \| 4-amino-2-(2,6-dioxopiperidin-3-yl)is...) Show SMILES Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celgene					Assay Description To measure compound binding to endogenous CRBN.				Leukemia 26: 2326-35 (2012) Article DOI: 10.1038/leu.2012.119 BindingDB Entry DOI: 10.7270/Q26971RH
Celgene					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM65454 (191732-72-6 \| CC-5013 \| Lenalidomide \| Revimid \| R...) Show SMILES Nc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	8.0	70
Celgene					Assay Description Thermal stabilities of CRBN-DDB1 in the presence or absence of phthalimide, thalidomide, lenalidomide and pomalidomide were done in the presence of S...				Leukemia 26: 2326-35 (2012) Article DOI: 10.1038/leu.2012.119 BindingDB Entry DOI: 10.7270/Q26971RH
Celgene					More data for this Ligand-Target Pair				3D Structure (crystal)
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM65456 (19171-19-8 \| 4-amino-2-(2,6-dioxopiperidin-3-yl)is...) Show SMILES Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	8.0	70
Celgene					Assay Description Thermal stabilities of CRBN-DDB1 in the presence or absence of phthalimide, thalidomide, lenalidomide and pomalidomide were done in the presence of S...				Leukemia 26: 2326-35 (2012) Article DOI: 10.1038/leu.2012.119 BindingDB Entry DOI: 10.7270/Q26971RH
Celgene					More data for this Ligand-Target Pair
Protein cereblon (Homo sapiens (Human))	BDBM65457 ((-)-Thalidomide \| (S)-Thalidomide) Show SMILES O=C1N([C@H]2CCC(=O)NC2=O)C(=O)c2ccccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Celgene					Assay Description To measure compound binding to endogenous CRBN.				Leukemia 26: 2326-35 (2012) Article DOI: 10.1038/leu.2012.119 BindingDB Entry DOI: 10.7270/Q26971RH
Celgene					More data for this Ligand-Target Pair				3D Structure (crystal)
DNA damage-binding protein 1 (Homo sapiens (Human))	BDBM50070114 ((+/-)-thalidomide \| 2-(2,6-Dioxo-piperidin-3-yl)-i...) Show SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)c2ccccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	8.0	70
Celgene					Assay Description Thermal stabilities of CRBN-DDB1 in the presence or absence of phthalimide, thalidomide, lenalidomide and pomalidomide were done in the presence of S...				Leukemia 26: 2326-35 (2012) Article DOI: 10.1038/leu.2012.119 BindingDB Entry DOI: 10.7270/Q26971RH
Celgene					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein cereblon (Homo sapiens (Human))	BDBM65362 ((+)-Thalidomide \| (R)-(+)-thalidomide \| (R)-Thalid...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Celgene					Assay Description To measure compound binding to endogenous CRBN.				Leukemia 26: 2326-35 (2012) Article DOI: 10.1038/leu.2012.119 BindingDB Entry DOI: 10.7270/Q26971RH
Celgene					More data for this Ligand-Target Pair				3D Structure (crystal)
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50545276 (CHEMBL4637801) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Celgene Corporation Curated by ChEMBL					Assay Description Agonist activity at D2S (unknown origin)				J Med Chem 63: 6648-6676 (2020) Article DOI: 10.1021/acs.jmedchem.9b01928 BindingDB Entry DOI: 10.7270/Q2KS6W4N
Celgene Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50545275 (CHEMBL4645677) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	16	n/a	n/a	n/a	n/a
Celgene Corporation Curated by ChEMBL					Assay Description Agonist activity at D2S (unknown origin)				J Med Chem 63: 6648-6676 (2020) Article DOI: 10.1021/acs.jmedchem.9b01928 BindingDB Entry DOI: 10.7270/Q2KS6W4N
Celgene Corporation Curated by ChEMBL					More data for this Ligand-Target Pair