Compile Data Set for Download or QSAR

Found 54 hits with Last Name = 'luong' and Initial = 'm'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50349469 (CHEMBL1808589) Show SMILES Cc1c(CNCCO)cncc1-c1ccc2[nH]nc(-c3nc4ccccc4[nH]3)c2c1 Show InChI InChI=1S/C23H22N6O/c1-14-16(11-24-8-9-30)12-25-13-18(14)15-6-7-19-17(10-15)22(29-28-19)23-26-20-4-2-3-5-21(20)27-23/h2-7,10,12-13,24,30H,8-9,11H2,1H3,(H,26,27)(H,28,29)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2 using GST-MEK as substrate by LANCE assay				Bioorg Med Chem Lett 21: 4758-61 (2011) Article DOI: 10.1016/j.bmcl.2011.06.065 BindingDB Entry DOI: 10.7270/Q28W3DP4
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50349452 (CHEMBL1808572) Show SMILES CCNCc1cncc(-c2ccc3[nH]nc(-c4nc5ccccc5[nH]4)c3c2)c1C Show InChI InChI=1S/C23H22N6/c1-3-24-11-16-12-25-13-18(14(16)2)15-8-9-19-17(10-15)22(29-28-19)23-26-20-6-4-5-7-21(20)27-23/h4-10,12-13,24H,3,11H2,1-2H3,(H,26,27)(H,28,29)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	109	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2 using GST-MEK as substrate by LANCE assay				Bioorg Med Chem Lett 21: 4758-61 (2011) Article DOI: 10.1016/j.bmcl.2011.06.065 BindingDB Entry DOI: 10.7270/Q28W3DP4
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50354559 (CHEMBL1836724) Show SMILES CC(=O)Nc1ccc(cc1)-c1cc2ncnc(SCC(O)=O)c2s1 Show InChI InChI=1S/C16H13N3O3S2/c1-9(20)19-11-4-2-10(3-5-11)13-6-12-15(24-13)16(18-8-17-12)23-7-14(21)22/h2-6,8H,7H2,1H3,(H,19,20)(H,21,22)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2				Bioorg Med Chem Lett 21: 5952-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.069 BindingDB Entry DOI: 10.7270/Q2X63NC0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50349450 (CHEMBL1808570) Show SMILES CCNCc1cncc(-c2ccc3[nH]nc(-c4nc5cc(C)c(C)cc5[nH]4)c3c2)c1C Show InChI InChI=1S/C25H26N6/c1-5-26-11-18-12-27-13-20(16(18)4)17-6-7-21-19(10-17)24(31-30-21)25-28-22-8-14(2)15(3)9-23(22)29-25/h6-10,12-13,26H,5,11H2,1-4H3,(H,28,29)(H,30,31)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2 using GST-MEK as substrate by LANCE assay				Bioorg Med Chem Lett 21: 4758-61 (2011) Article DOI: 10.1016/j.bmcl.2011.06.065 BindingDB Entry DOI: 10.7270/Q28W3DP4
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50349451 (CHEMBL1808571) Show SMILES CCNCc1cncc(-c2ccc3[nH]nc(-c4nc5ccc(C)cc5[nH]4)c3c2)c1C Show InChI InChI=1S/C24H24N6/c1-4-25-11-17-12-26-13-19(15(17)3)16-6-8-20-18(10-16)23(30-29-20)24-27-21-7-5-14(2)9-22(21)28-24/h5-10,12-13,25H,4,11H2,1-3H3,(H,27,28)(H,29,30)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	418	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2 using GST-MEK as substrate by LANCE assay				Bioorg Med Chem Lett 21: 4758-61 (2011) Article DOI: 10.1016/j.bmcl.2011.06.065 BindingDB Entry DOI: 10.7270/Q28W3DP4
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50354560 (CHEMBL1836641) Show SMILES OC(=O)COc1ncnc2cc(sc12)-c1ccc2[nH]ncc2c1 Show InChI InChI=1S/C15H10N4O3S/c20-13(21)6-22-15-14-11(16-7-17-15)4-12(23-14)8-1-2-10-9(3-8)5-18-19-10/h1-5,7H,6H2,(H,18,19)(H,20,21)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2				Bioorg Med Chem Lett 21: 5952-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.069 BindingDB Entry DOI: 10.7270/Q2X63NC0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50354540 (CHEMBL1836717) Show SMILES OC(=O)CSc1ncnc2cc(sc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C15H9N3O2S2/c16-6-9-1-3-10(4-2-9)12-5-11-14(22-12)15(18-8-17-11)21-7-13(19)20/h1-5,8H,7H2,(H,19,20)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2				Bioorg Med Chem Lett 21: 5952-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.069 BindingDB Entry DOI: 10.7270/Q2X63NC0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50349453 (CHEMBL1808573) Show SMILES CCNCc1cncc(-c2ccc3[nH]nc(-c4nc5ccc(Br)cc5[nH]4)c3c2)c1C Show InChI InChI=1S/C23H21BrN6/c1-3-25-10-15-11-26-12-18(13(15)2)14-4-6-19-17(8-14)22(30-29-19)23-27-20-7-5-16(24)9-21(20)28-23/h4-9,11-12,25H,3,10H2,1-2H3,(H,27,28)(H,29,30)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.13E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2 using GST-MEK as substrate by LANCE assay				Bioorg Med Chem Lett 21: 4758-61 (2011) Article DOI: 10.1016/j.bmcl.2011.06.065 BindingDB Entry DOI: 10.7270/Q28W3DP4
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50354541 (CHEMBL1836714) Show SMILES OC(=O)CSc1ncnc2cc(sc12)-c1ccc(Cl)cc1 Show InChI InChI=1S/C14H9ClN2O2S2/c15-9-3-1-8(2-4-9)11-5-10-13(21-11)14(17-7-16-10)20-6-12(18)19/h1-5,7H,6H2,(H,18,19)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2				Bioorg Med Chem Lett 21: 5952-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.069 BindingDB Entry DOI: 10.7270/Q2X63NC0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50349456 (CHEMBL1808576) Show SMILES CCNCc1cncc(-c2ccc3[nH]nc(-c4nc5ccc(COC(C)C)cc5[nH]4)c3c2)c1C Show InChI InChI=1S/C27H30N6O/c1-5-28-12-20-13-29-14-22(17(20)4)19-7-9-23-21(11-19)26(33-32-23)27-30-24-8-6-18(10-25(24)31-27)15-34-16(2)3/h6-11,13-14,16,28H,5,12,15H2,1-4H3,(H,30,31)(H,32,33)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.46E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2 using GST-MEK as substrate by LANCE assay				Bioorg Med Chem Lett 21: 4758-61 (2011) Article DOI: 10.1016/j.bmcl.2011.06.065 BindingDB Entry DOI: 10.7270/Q28W3DP4
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50354542 (CHEMBL1836721) Show SMILES NC(=O)c1ccc(cc1)-c1cc2ncnc(SCC(O)=O)c2s1 Show InChI InChI=1S/C15H11N3O3S2/c16-14(21)9-3-1-8(2-4-9)11-5-10-13(23-11)15(18-7-17-10)22-6-12(19)20/h1-5,7H,6H2,(H2,16,21)(H,19,20)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2				Bioorg Med Chem Lett 21: 5952-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.069 BindingDB Entry DOI: 10.7270/Q2X63NC0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50354544 (CHEMBL1836718) Show SMILES COc1ccc(cc1)-c1cc2ncnc(SCC(O)=O)c2s1 Show InChI InChI=1S/C15H12N2O3S2/c1-20-10-4-2-9(3-5-10)12-6-11-14(22-12)15(17-8-16-11)21-7-13(18)19/h2-6,8H,7H2,1H3,(H,18,19)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2				Bioorg Med Chem Lett 21: 5952-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.069 BindingDB Entry DOI: 10.7270/Q2X63NC0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50354543 (CHEMBL1836715) Show SMILES Cc1ccc(cc1)-c1cc2ncnc(SCC(O)=O)c2s1 Show InChI InChI=1S/C15H12N2O2S2/c1-9-2-4-10(5-3-9)12-6-11-14(21-12)15(17-8-16-11)20-7-13(18)19/h2-6,8H,7H2,1H3,(H,18,19)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2				Bioorg Med Chem Lett 21: 5952-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.069 BindingDB Entry DOI: 10.7270/Q2X63NC0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50349454 (CHEMBL1808574) Show SMILES CCNCc1cncc(-c2ccc3[nH]nc(-c4nc5cc(Cl)c(C)cc5[nH]4)c3c2)c1C Show InChI InChI=1S/C24H23ClN6/c1-4-26-10-16-11-27-12-18(14(16)3)15-5-6-20-17(8-15)23(31-30-20)24-28-21-7-13(2)19(25)9-22(21)29-24/h5-9,11-12,26H,4,10H2,1-3H3,(H,28,29)(H,30,31)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.73E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2 using GST-MEK as substrate by LANCE assay				Bioorg Med Chem Lett 21: 4758-61 (2011) Article DOI: 10.1016/j.bmcl.2011.06.065 BindingDB Entry DOI: 10.7270/Q28W3DP4
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50349455 (CHEMBL1808575) Show SMILES CCNCc1cncc(-c2ccc3[nH]nc(-c4nc5ccc(cc5[nH]4)C(C)(C)C)c3c2)c1C Show InChI InChI=1S/C27H30N6/c1-6-28-13-18-14-29-15-21(16(18)2)17-7-9-22-20(11-17)25(33-32-22)26-30-23-10-8-19(27(3,4)5)12-24(23)31-26/h7-12,14-15,28H,6,13H2,1-5H3,(H,30,31)(H,32,33)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2 using GST-MEK as substrate by LANCE assay				Bioorg Med Chem Lett 21: 4758-61 (2011) Article DOI: 10.1016/j.bmcl.2011.06.065 BindingDB Entry DOI: 10.7270/Q28W3DP4
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50354545 (CHEMBL1836640) Show SMILES OC(=O)COc1ncnc2cc(sc12)-c1ccc2[nH]ccc2c1 Show InChI InChI=1S/C16H11N3O3S/c20-14(21)7-22-16-15-12(18-8-19-16)6-13(23-15)10-1-2-11-9(5-10)3-4-17-11/h1-6,8,17H,7H2,(H,20,21)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2				Bioorg Med Chem Lett 21: 5952-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.069 BindingDB Entry DOI: 10.7270/Q2X63NC0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50349457 (CHEMBL1808577) Show SMILES CCNCc1cncc(-c2ccc3[nH]nc(-c4nc5ccc(cc5[nH]4)C#N)c3c2)c1C Show InChI InChI=1S/C24H21N7/c1-3-26-11-17-12-27-13-19(14(17)2)16-5-7-20-18(9-16)23(31-30-20)24-28-21-6-4-15(10-25)8-22(21)29-24/h4-9,12-13,26H,3,11H2,1-2H3,(H,28,29)(H,30,31)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.67E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2 using GST-MEK as substrate by LANCE assay				Bioorg Med Chem Lett 21: 4758-61 (2011) Article DOI: 10.1016/j.bmcl.2011.06.065 BindingDB Entry DOI: 10.7270/Q28W3DP4
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50349467 (CHEMBL1808587) Show SMILES CCNCc1cncc(-c2ccc3[nH]nc(-c4nc(c(C)[nH]4)-c4ccccc4)c3c2)c1C Show InChI InChI=1S/C26H26N6/c1-4-27-13-20-14-28-15-22(16(20)2)19-10-11-23-21(12-19)25(32-31-23)26-29-17(3)24(30-26)18-8-6-5-7-9-18/h5-12,14-15,27H,4,13H2,1-3H3,(H,29,30)(H,31,32)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2 using GST-MEK as substrate by LANCE assay				Bioorg Med Chem Lett 21: 4758-61 (2011) Article DOI: 10.1016/j.bmcl.2011.06.065 BindingDB Entry DOI: 10.7270/Q28W3DP4
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50349449 (CHEMBL1808569) Show SMILES CCNCc1cncc(-c2ccc3[nH]nc(-c4nc5ccc(CN6CCCCC6)cc5[nH]4)c3c2)c1C Show InChI InChI=1S/C29H33N7/c1-3-30-15-22-16-31-17-24(19(22)2)21-8-10-25-23(14-21)28(35-34-25)29-32-26-9-7-20(13-27(26)33-29)18-36-11-5-4-6-12-36/h7-10,13-14,16-17,30H,3-6,11-12,15,18H2,1-2H3,(H,32,33)(H,34,35)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2 using GST-MEK as substrate by LANCE assay				Bioorg Med Chem Lett 21: 4758-61 (2011) Article DOI: 10.1016/j.bmcl.2011.06.065 BindingDB Entry DOI: 10.7270/Q28W3DP4
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50354546 (CHEMBL1836716) Show SMILES Cc1cccc(c1)-c1cc2ncnc(SCC(O)=O)c2s1 Show InChI InChI=1S/C15H12N2O2S2/c1-9-3-2-4-10(5-9)12-6-11-14(21-12)15(17-8-16-11)20-7-13(18)19/h2-6,8H,7H2,1H3,(H,18,19)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2				Bioorg Med Chem Lett 21: 5952-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.069 BindingDB Entry DOI: 10.7270/Q2X63NC0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50349468 (CHEMBL1808588) Show SMILES CCNCc1cncc(-c2ccc3[nH]nc(-c4nc(c[nH]4)-c4cccc(F)c4)c3c2)c1C Show InChI InChI=1S/C25H23FN6/c1-3-27-11-18-12-28-13-21(15(18)2)16-7-8-22-20(10-16)24(32-31-22)25-29-14-23(30-25)17-5-4-6-19(26)9-17/h4-10,12-14,27H,3,11H2,1-2H3,(H,29,30)(H,31,32)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2 using GST-MEK as substrate by LANCE assay				Bioorg Med Chem Lett 21: 4758-61 (2011) Article DOI: 10.1016/j.bmcl.2011.06.065 BindingDB Entry DOI: 10.7270/Q28W3DP4
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50354547 (CHEMBL1836712) Show SMILES OC(=O)CSc1ncnc2cc(sc12)-c1ccc(Br)cc1 Show InChI InChI=1S/C14H9BrN2O2S2/c15-9-3-1-8(2-4-9)11-5-10-13(21-11)14(17-7-16-10)20-6-12(18)19/h1-5,7H,6H2,(H,18,19)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2				Bioorg Med Chem Lett 21: 5952-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.069 BindingDB Entry DOI: 10.7270/Q2X63NC0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50349458 (CHEMBL1808578) Show SMILES CCNCc1cncc(-c2ccc3[nH]nc(-c4nc5cc(C#N)c(F)cc5[nH]4)c3c2)c1C Show InChI InChI=1S/C24H20FN7/c1-3-27-10-16-11-28-12-18(13(16)2)14-4-5-20-17(6-14)23(32-31-20)24-29-21-7-15(9-26)19(25)8-22(21)30-24/h4-8,11-12,27H,3,10H2,1-2H3,(H,29,30)(H,31,32)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.94E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2 using GST-MEK as substrate by LANCE assay				Bioorg Med Chem Lett 21: 4758-61 (2011) Article DOI: 10.1016/j.bmcl.2011.06.065 BindingDB Entry DOI: 10.7270/Q28W3DP4
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50354548 (CHEMBL1836726) Show SMILES CCOC(=O)CSc1ncnc2cc(I)sc12 Show InChI InChI=1S/C10H9IN2O2S2/c1-2-15-8(14)4-16-10-9-6(12-5-13-10)3-7(11)17-9/h3,5H,2,4H2,1H3	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2				Bioorg Med Chem Lett 21: 5952-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.069 BindingDB Entry DOI: 10.7270/Q2X63NC0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50354549 (CHEMBL1836639) Show SMILES OC(=O)COc1ncnc2cc(sc12)-c1ccc2NC(=O)CCc2c1 Show InChI InChI=1S/C17H13N3O4S/c21-14-4-2-9-5-10(1-3-11(9)20-14)13-6-12-16(25-13)17(19-8-18-12)24-7-15(22)23/h1,3,5-6,8H,2,4,7H2,(H,20,21)(H,22,23)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2				Bioorg Med Chem Lett 21: 5952-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.069 BindingDB Entry DOI: 10.7270/Q2X63NC0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50354550 (CHEMBL1836722) Show SMILES NC(=O)c1cccc(c1)-c1cc2ncnc(SCC(O)=O)c2s1 Show InChI InChI=1S/C15H11N3O3S2/c16-14(21)9-3-1-2-8(4-9)11-5-10-13(23-11)15(18-7-17-10)22-6-12(19)20/h1-5,7H,6H2,(H2,16,21)(H,19,20)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2				Bioorg Med Chem Lett 21: 5952-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.069 BindingDB Entry DOI: 10.7270/Q2X63NC0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50354551 (CHEMBL1836713) Show SMILES OC(=O)CSc1ncnc2cc(sc12)-c1ccc(F)cc1 Show InChI InChI=1S/C14H9FN2O2S2/c15-9-3-1-8(2-4-9)11-5-10-13(21-11)14(17-7-16-10)20-6-12(18)19/h1-5,7H,6H2,(H,18,19)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2				Bioorg Med Chem Lett 21: 5952-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.069 BindingDB Entry DOI: 10.7270/Q2X63NC0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50349471 (CHEMBL1808591) Show SMILES CCNCc1cncc(-c2ccc3[nH]nc(-c4nc5ccccc5[nH]4)c3c2)c1Cl Show InChI InChI=1S/C22H19ClN6/c1-2-24-10-14-11-25-12-16(20(14)23)13-7-8-17-15(9-13)21(29-28-17)22-26-18-5-3-4-6-19(18)27-22/h3-9,11-12,24H,2,10H2,1H3,(H,26,27)(H,28,29)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.26E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2 using GST-MEK as substrate by LANCE assay				Bioorg Med Chem Lett 21: 4758-61 (2011) Article DOI: 10.1016/j.bmcl.2011.06.065 BindingDB Entry DOI: 10.7270/Q28W3DP4
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50354552 (CHEMBL1836638) Show SMILES CC(=O)Nc1ccc(cc1)-c1cc2ncnc(OCC(O)=O)c2s1 Show InChI InChI=1S/C16H13N3O4S/c1-9(20)19-11-4-2-10(3-5-11)13-6-12-15(24-13)16(18-8-17-12)23-7-14(21)22/h2-6,8H,7H2,1H3,(H,19,20)(H,21,22)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2				Bioorg Med Chem Lett 21: 5952-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.069 BindingDB Entry DOI: 10.7270/Q2X63NC0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50349461 (CHEMBL1808581) Show SMILES CCNCc1cncc(-c2ccc3[nH]nc(-c4nc5ccc(Cl)c(Cl)c5[nH]4)c3c2)c1C Show InChI InChI=1S/C23H20Cl2N6/c1-3-26-9-14-10-27-11-16(12(14)2)13-4-6-18-15(8-13)21(31-30-18)23-28-19-7-5-17(24)20(25)22(19)29-23/h4-8,10-11,26H,3,9H2,1-2H3,(H,28,29)(H,30,31)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.03E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2 using GST-MEK as substrate by LANCE assay				Bioorg Med Chem Lett 21: 4758-61 (2011) Article DOI: 10.1016/j.bmcl.2011.06.065 BindingDB Entry DOI: 10.7270/Q28W3DP4
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50349470 (CHEMBL1808590) Show SMILES CC(C)CNCc1cncc(-c2ccc3[nH]nc(-c4nc5ccccc5[nH]4)c3c2)c1C Show InChI InChI=1S/C25H26N6/c1-15(2)11-26-12-18-13-27-14-20(16(18)3)17-8-9-21-19(10-17)24(31-30-21)25-28-22-6-4-5-7-23(22)29-25/h4-10,13-15,26H,11-12H2,1-3H3,(H,28,29)(H,30,31)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2 using GST-MEK as substrate by LANCE assay				Bioorg Med Chem Lett 21: 4758-61 (2011) Article DOI: 10.1016/j.bmcl.2011.06.065 BindingDB Entry DOI: 10.7270/Q28W3DP4
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50354553 (CHEMBL1836727) Show SMILES OC(=O)CSc1ncnc2cc(I)sc12 Show InChI InChI=1S/C8H5IN2O2S2/c9-5-1-4-7(15-5)8(11-3-10-4)14-2-6(12)13/h1,3H,2H2,(H,12,13)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2				Bioorg Med Chem Lett 21: 5952-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.069 BindingDB Entry DOI: 10.7270/Q2X63NC0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50349466 (CHEMBL1808586) Show SMILES CCNCc1cncc(-c2ccc3[nH]nc(-c4nc(C)c(CC(C)C)[nH]4)c3c2)c1C Show InChI InChI=1S/C24H30N6/c1-6-25-11-18-12-26-13-20(15(18)4)17-7-8-21-19(10-17)23(30-29-21)24-27-16(5)22(28-24)9-14(2)3/h7-8,10,12-14,25H,6,9,11H2,1-5H3,(H,27,28)(H,29,30)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.87E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2 using GST-MEK as substrate by LANCE assay				Bioorg Med Chem Lett 21: 4758-61 (2011) Article DOI: 10.1016/j.bmcl.2011.06.065 BindingDB Entry DOI: 10.7270/Q28W3DP4
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50349459 (CHEMBL1808579) Show SMILES CCNCc1cncc(-c2ccc3[nH]nc(-c4nc5ccc(F)c(F)c5[nH]4)c3c2)c1C Show InChI InChI=1S/C23H20F2N6/c1-3-26-9-14-10-27-11-16(12(14)2)13-4-6-18-15(8-13)21(31-30-18)23-28-19-7-5-17(24)20(25)22(19)29-23/h4-8,10-11,26H,3,9H2,1-2H3,(H,28,29)(H,30,31)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.07E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2 using GST-MEK as substrate by LANCE assay				Bioorg Med Chem Lett 21: 4758-61 (2011) Article DOI: 10.1016/j.bmcl.2011.06.065 BindingDB Entry DOI: 10.7270/Q28W3DP4
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50349460 (CHEMBL1808580) Show SMILES CCNCc1cncc(-c2ccc3[nH]nc(-c4nc5cc(F)c(F)cc5[nH]4)c3c2)c1C Show InChI InChI=1S/C23H20F2N6/c1-3-26-9-14-10-27-11-16(12(14)2)13-4-5-19-15(6-13)22(31-30-19)23-28-20-7-17(24)18(25)8-21(20)29-23/h4-8,10-11,26H,3,9H2,1-2H3,(H,28,29)(H,30,31)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.14E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2 using GST-MEK as substrate by LANCE assay				Bioorg Med Chem Lett 21: 4758-61 (2011) Article DOI: 10.1016/j.bmcl.2011.06.065 BindingDB Entry DOI: 10.7270/Q28W3DP4
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50354554 (CHEMBL1836728) Show SMILES COc1ccc(cn1)-c1cc2ncnc(SCC(O)=O)c2s1 Show InChI InChI=1S/C14H11N3O3S2/c1-20-11-3-2-8(5-15-11)10-4-9-13(22-10)14(17-7-16-9)21-6-12(18)19/h2-5,7H,6H2,1H3,(H,18,19)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2				Bioorg Med Chem Lett 21: 5952-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.069 BindingDB Entry DOI: 10.7270/Q2X63NC0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50349462 (CHEMBL1808582) Show SMILES CCNCc1cncc(-c2ccc3[nH]nc(-c4ncc[nH]4)c3c2)c1C Show InChI InChI=1S/C19H20N6/c1-3-20-9-14-10-21-11-16(12(14)2)13-4-5-17-15(8-13)18(25-24-17)19-22-6-7-23-19/h4-8,10-11,20H,3,9H2,1-2H3,(H,22,23)(H,24,25)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2 using GST-MEK as substrate by LANCE assay				Bioorg Med Chem Lett 21: 4758-61 (2011) Article DOI: 10.1016/j.bmcl.2011.06.065 BindingDB Entry DOI: 10.7270/Q28W3DP4
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50349465 (CHEMBL1808585) Show SMILES CCNCc1cncc(-c2ccc3[nH]nc(-c4nc5ccncc5[nH]4)c3c2)c1C Show InChI InChI=1S/C22H21N7/c1-3-23-9-15-10-25-11-17(13(15)2)14-4-5-18-16(8-14)21(29-28-18)22-26-19-6-7-24-12-20(19)27-22/h4-8,10-12,23H,3,9H2,1-2H3,(H,26,27)(H,28,29)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.83E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2 using GST-MEK as substrate by LANCE assay				Bioorg Med Chem Lett 21: 4758-61 (2011) Article DOI: 10.1016/j.bmcl.2011.06.065 BindingDB Entry DOI: 10.7270/Q28W3DP4
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50354555 (CHEMBL1836637) Show SMILES OC(=O)COc1ncnc2cc(sc12)-c1ccc(Cl)cc1 Show InChI InChI=1S/C14H9ClN2O3S/c15-9-3-1-8(2-4-9)11-5-10-13(21-11)14(17-7-16-10)20-6-12(18)19/h1-5,7H,6H2,(H,18,19)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2				Bioorg Med Chem Lett 21: 5952-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.069 BindingDB Entry DOI: 10.7270/Q2X63NC0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50354565 (CHEMBL1836719) Show SMILES CSc1ccc(cc1)-c1cc2ncnc(SCC(O)=O)c2s1 Show InChI InChI=1S/C15H12N2O2S3/c1-20-10-4-2-9(3-5-10)12-6-11-14(22-12)15(17-8-16-11)21-7-13(18)19/h2-6,8H,7H2,1H3,(H,18,19)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2				Bioorg Med Chem Lett 21: 5952-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.069 BindingDB Entry DOI: 10.7270/Q2X63NC0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50349464 (CHEMBL1808584) Show SMILES CCNCc1cncc(-c2ccc3[nH]nc(-c4nc5CCCCc5[nH]4)c3c2)c1C Show InChI InChI=1S/C23H26N6/c1-3-24-11-16-12-25-13-18(14(16)2)15-8-9-19-17(10-15)22(29-28-19)23-26-20-6-4-5-7-21(20)27-23/h8-10,12-13,24H,3-7,11H2,1-2H3,(H,26,27)(H,28,29)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2 using GST-MEK as substrate by LANCE assay				Bioorg Med Chem Lett 21: 4758-61 (2011) Article DOI: 10.1016/j.bmcl.2011.06.065 BindingDB Entry DOI: 10.7270/Q28W3DP4
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50354564 (CHEMBL1836643) Show SMILES CN(CC(O)=O)c1ncnc2cc(sc12)-c1ccc(Cl)cc1 Show InChI InChI=1S/C15H12ClN3O2S/c1-19(7-13(20)21)15-14-11(17-8-18-15)6-12(22-14)9-2-4-10(16)5-3-9/h2-6,8H,7H2,1H3,(H,20,21)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2				Bioorg Med Chem Lett 21: 5952-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.069 BindingDB Entry DOI: 10.7270/Q2X63NC0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50354563 (CHEMBL1836642) Show SMILES OC(=O)CNc1ncnc2cc(sc12)-c1ccc(Cl)cc1 Show InChI InChI=1S/C14H10ClN3O2S/c15-9-3-1-8(2-4-9)11-5-10-13(21-11)14(18-7-17-10)16-6-12(19)20/h1-5,7H,6H2,(H,19,20)(H,16,17,18)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2				Bioorg Med Chem Lett 21: 5952-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.069 BindingDB Entry DOI: 10.7270/Q2X63NC0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50354562 (CHEMBL1836636) Show SMILES CC1CCN(CC1)c1cc2ncnc(SCC(O)=O)c2s1 Show InChI InChI=1S/C14H17N3O2S2/c1-9-2-4-17(5-3-9)11-6-10-13(21-11)14(16-8-15-10)20-7-12(18)19/h6,8-9H,2-5,7H2,1H3,(H,18,19)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2				Bioorg Med Chem Lett 21: 5952-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.069 BindingDB Entry DOI: 10.7270/Q2X63NC0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50354561 (CHEMBL1836729) Show SMILES OC(=O)CSc1ncnc2cc(sc12)-c1ccc(Cl)s1 Show InChI InChI=1S/C12H7ClN2O2S3/c13-9-2-1-7(19-9)8-3-6-11(20-8)12(15-5-14-6)18-4-10(16)17/h1-3,5H,4H2,(H,16,17)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2				Bioorg Med Chem Lett 21: 5952-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.069 BindingDB Entry DOI: 10.7270/Q2X63NC0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50354558 (CHEMBL1836725) Show SMILES CCOC(=O)CSc1ncnc2cc(sc12)-c1ccc(Cl)cc1 Show InChI InChI=1S/C16H13ClN2O2S2/c1-2-21-14(20)8-22-16-15-12(18-9-19-16)7-13(23-15)10-3-5-11(17)6-4-10/h3-7,9H,2,8H2,1H3	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2				Bioorg Med Chem Lett 21: 5952-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.069 BindingDB Entry DOI: 10.7270/Q2X63NC0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50354557 (CHEMBL1836723) Show SMILES CNC(=O)c1ccc(cc1)-c1cc2ncnc(SCC(O)=O)c2s1 Show InChI InChI=1S/C16H13N3O3S2/c1-17-15(22)10-4-2-9(3-5-10)12-6-11-14(24-12)16(19-8-18-11)23-7-13(20)21/h2-6,8H,7H2,1H3,(H,17,22)(H,20,21)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2				Bioorg Med Chem Lett 21: 5952-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.069 BindingDB Entry DOI: 10.7270/Q2X63NC0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50354556 (CHEMBL1836720) Show SMILES OC(=O)CSc1ncnc2cc(sc12)-c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C20H14N2O2S2/c23-18(24)11-25-20-19-16(21-12-22-20)10-17(26-19)15-8-6-14(7-9-15)13-4-2-1-3-5-13/h1-10,12H,11H2,(H,23,24)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2				Bioorg Med Chem Lett 21: 5952-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.069 BindingDB Entry DOI: 10.7270/Q2X63NC0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50349476 (CHEMBL1808596) Show SMILES Cc1c(CN2CCOCC2)cncc1-c1ccc2[nH]nc(-c3nc4ccccc4[nH]3)c2c1 Show InChI InChI=1S/C25H24N6O/c1-16-18(15-31-8-10-32-11-9-31)13-26-14-20(16)17-6-7-21-19(12-17)24(30-29-21)25-27-22-4-2-3-5-23(22)28-25/h2-7,12-14H,8-11,15H2,1H3,(H,27,28)(H,29,30)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2 using GST-MEK as substrate by LANCE assay				Bioorg Med Chem Lett 21: 4758-61 (2011) Article DOI: 10.1016/j.bmcl.2011.06.065 BindingDB Entry DOI: 10.7270/Q28W3DP4
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50349474 (CHEMBL1808594) Show SMILES Cc1cncc(-c2ccc3[nH]nc(-c4nc5ccccc5[nH]4)c3c2)c1C Show InChI InChI=1S/C21H17N5/c1-12-10-22-11-16(13(12)2)14-7-8-17-15(9-14)20(26-25-17)21-23-18-5-3-4-6-19(18)24-21/h3-11H,1-2H3,(H,23,24)(H,25,26)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TPL2 using GST-MEK as substrate by LANCE assay				Bioorg Med Chem Lett 21: 4758-61 (2011) Article DOI: 10.1016/j.bmcl.2011.06.065 BindingDB Entry DOI: 10.7270/Q28W3DP4
					More data for this Ligand-Target Pair

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