Compile Data Set for Download or QSAR

Found 105 hits with Last Name = 'lyons' and Initial = 'dm'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Perforin-1 (Homo sapiens (Human))	BDBM50445263 (CHEMBL3103651) Show SMILES O=C1NC(=O)\C(N1)=C/c1ccc(s1)-c1ccc2C(=O)NCc2c1 Show InChI InChI=1S/C16H11N3O3S/c20-14-11-3-1-8(5-9(11)7-17-14)13-4-2-10(23-13)6-12-15(21)19-16(22)18-12/h1-6H,7H2,(H,17,20)(H2,18,19,21,22)/b12-6+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445286 (CHEMBL3103907) Show SMILES CN1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C17H13N3O2S2/c1-20-8-10-6-9(2-4-12(10)16(20)22)14-5-3-11(24-14)7-13-15(21)19-17(23)18-13/h2-7H,8H2,1H3,(H2,18,19,21,23)/b13-7+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445279 (CHEMBL3103914) Show SMILES OCCCN1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C19H17N3O3S2/c23-7-1-6-22-10-12-8-11(2-4-14(12)18(22)25)16-5-3-13(27-16)9-15-17(24)21-19(26)20-15/h2-5,8-9,23H,1,6-7,10H2,(H2,20,21,24,26)/b15-9+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445276 (CHEMBL3103917) Show SMILES CCOC(=O)N1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C19H15N3O4S2/c1-2-26-19(25)22-9-11-7-10(3-5-13(11)17(22)24)15-6-4-12(28-15)8-14-16(23)21-18(27)20-14/h3-8H,2,9H2,1H3,(H2,20,21,23,27)/b14-8+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445285 (CHEMBL3103908) Show SMILES CCN1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C18H15N3O2S2/c1-2-21-9-11-7-10(3-5-13(11)17(21)23)15-6-4-12(25-15)8-14-16(22)20-18(24)19-14/h3-8H,2,9H2,1H3,(H2,19,20,22,24)/b14-8+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445259 (CHEMBL3103655) Show SMILES O=C1NC(=S)N\C1=C\c1ccc(cn1)-c1ccc2C(=O)NCc2c1 Show InChI InChI=1S/C17H12N4O2S/c22-15-13-4-2-9(5-11(13)8-19-15)10-1-3-12(18-7-10)6-14-16(23)21-17(24)20-14/h1-7H,8H2,(H,19,22)(H2,20,21,23,24)/b14-6+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	630	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445267 (CHEMBL3103647) Show SMILES O=C1NC(=S)N\C1=C\c1ccc(s1)-c1ccc2CCNC(=O)c2c1 Show InChI InChI=1S/C17H13N3O2S2/c21-15-12-7-10(2-1-9(12)5-6-18-15)14-4-3-11(24-14)8-13-16(22)20-17(23)19-13/h1-4,7-8H,5-6H2,(H,18,21)(H2,19,20,22,23)/b13-8+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	640	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445280 (CHEMBL3103913) Show SMILES OCCN1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C18H15N3O3S2/c22-6-5-21-9-11-7-10(1-3-13(11)17(21)24)15-4-2-12(26-15)8-14-16(23)20-18(25)19-14/h1-4,7-8,22H,5-6,9H2,(H2,19,20,23,25)/b14-8+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	780	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445303 (CHEMBL3102870) Show SMILES NC(=O)c1cccc(c1)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C15H11N3O2S2/c16-13(19)9-3-1-2-8(6-9)12-5-4-10(22-12)7-11-14(20)18-15(21)17-11/h1-7H,(H2,16,19)(H2,17,18,20,21)/b11-7+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	790	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445277 (CHEMBL3103916) Show SMILES CC(=O)N1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C18H13N3O3S2/c1-9(22)21-8-11-6-10(2-4-13(11)17(21)24)15-5-3-12(26-15)7-14-16(23)20-18(25)19-14/h2-7H,8H2,1H3,(H2,19,20,23,25)/b14-7+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	930	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50275059 ((Z)-1-(Benzo[b]thiophen-3-ylmethylene)-6-methyl-4-...) Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1csc2ccccc12 Show InChI InChI=1S/C17H11NO2S2/c1-9-6-12-13(20-17(19)15(12)16(21)18-9)7-10-8-22-14-5-3-2-4-11(10)14/h2-8H,1H3,(H,18,21)/b13-7-	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	970	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin mediated lysis of human Jurkat cells pre-incubated for 30 mins with perforin followed by incubation with Jurkat ce...				Bioorg Med Chem 19: 4091-100 (2011) Article DOI: 10.1016/j.bmc.2011.05.013 BindingDB Entry DOI: 10.7270/Q2W66M48
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50347203 (CHEMBL1795754) Show SMILES CNC(=O)c1ccc(cc1)-c1c(C#N)c(N)n2c3ccccc3nc2c1C#N Show InChI InChI=1S/C21H14N6O/c1-25-21(28)13-8-6-12(7-9-13)18-14(10-22)19(24)27-17-5-3-2-4-16(17)26-20(27)15(18)11-23/h2-9H,24H2,1H3,(H,25,28)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.04E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin mediated lysis of human Jurkat cells pre-incubated for 30 mins with perforin followed by incubation with Jurkat ce...				Bioorg Med Chem 19: 4091-100 (2011) Article DOI: 10.1016/j.bmc.2011.05.013 BindingDB Entry DOI: 10.7270/Q2W66M48
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445268 (CHEMBL3103646) Show SMILES O=C1NC(=S)N\C1=C\c1ccc(s1)-c1ccc2C(=O)NCCc2c1 Show InChI InChI=1S/C17H13N3O2S2/c21-15-12-3-1-10(7-9(12)5-6-18-15)14-4-2-11(24-14)8-13-16(22)20-17(23)19-13/h1-4,7-8H,5-6H2,(H,18,21)(H2,19,20,22,23)/b13-8+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.14E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445307 (CHEMBL3104019) Show SMILES CSc1ccc(cc1)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C15H12N2OS3/c1-20-10-4-2-9(3-5-10)13-7-6-11(21-13)8-12-14(18)17-15(19)16-12/h2-8H,1H3,(H2,16,17,18,19)/b12-8+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.15E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445281 (CHEMBL3103912) Show SMILES CC(=O)OCCN1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C20H17N3O4S2/c1-11(24)27-7-6-23-10-13-8-12(2-4-15(13)19(23)26)17-5-3-14(29-17)9-16-18(25)22-20(28)21-16/h2-5,8-9H,6-7,10H2,1H3,(H2,21,22,25,28)/b16-9+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.17E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445283 (CHEMBL3103910) Show SMILES CCCCN1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C20H19N3O2S2/c1-2-3-8-23-11-13-9-12(4-6-15(13)19(23)25)17-7-5-14(27-17)10-16-18(24)22-20(26)21-16/h4-7,9-10H,2-3,8,11H2,1H3,(H2,21,22,24,26)/b16-10+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.18E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445278 (CHEMBL3103915) Show SMILES OCC(O)CN1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C19H17N3O4S2/c23-9-12(24)8-22-7-11-5-10(1-3-14(11)18(22)26)16-4-2-13(28-16)6-15-17(25)21-19(27)20-15/h1-6,12,23-24H,7-9H2,(H2,20,21,25,27)/b15-6+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.26E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445270 (CHEMBL3103644) Show SMILES O=C1NC(=S)N\C1=C\c1ccc(s1)-c1ccc2CNC(=O)c2c1 Show InChI InChI=1S/C16H11N3O2S2/c20-14-11-5-8(1-2-9(11)7-17-14)13-4-3-10(23-13)6-12-15(21)19-16(22)18-12/h1-6H,7H2,(H,17,20)(H2,18,19,21,22)/b12-6+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.38E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445255 (CHEMBL3103900) Show SMILES O=C1NC(=S)N\C1=C\c1cc2cc(ccc2[nH]1)-c1ccc2C(=O)NCCc2c1 Show InChI InChI=1S/C21H16N4O2S/c26-19-16-3-1-11(7-13(16)5-6-22-19)12-2-4-17-14(8-12)9-15(23-17)10-18-20(27)25-21(28)24-18/h1-4,7-10,23H,5-6H2,(H,22,26)(H2,24,25,27,28)/b18-10+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.45E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445284 (CHEMBL3103909) Show SMILES CCCN1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C19H17N3O2S2/c1-2-7-22-10-12-8-11(3-5-14(12)18(22)24)16-6-4-13(26-16)9-15-17(23)21-19(25)20-15/h3-6,8-9H,2,7,10H2,1H3,(H2,20,21,23,25)/b15-9+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.52E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445302 (CHEMBL3104023) Show SMILES NC(=O)c1ccc(cc1)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C15H11N3O2S2/c16-13(19)9-3-1-8(2-4-9)12-6-5-10(22-12)7-11-14(20)18-15(21)17-11/h1-7H,(H2,16,19)(H2,17,18,20,21)/b11-7+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.56E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445258 (CHEMBL3103897) Show SMILES O=C1NC(=S)N\C1=C\c1cc2ccc(cc2[nH]1)-c1ccc2C(=O)NCc2c1 Show InChI InChI=1S/C20H14N4O2S/c25-18-15-4-3-10(5-13(15)9-21-18)11-1-2-12-6-14(22-16(12)7-11)8-17-19(26)24-20(27)23-17/h1-8,22H,9H2,(H,21,25)(H2,23,24,26,27)/b17-8+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.58E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445304 (CHEMBL3104022) Show SMILES COC(=O)c1ccc(cc1)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C16H12N2O3S2/c1-21-15(20)10-4-2-9(3-5-10)13-7-6-11(23-13)8-12-14(19)18-16(22)17-12/h2-8H,1H3,(H2,17,18,19,22)/b12-8+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.62E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445256 (CHEMBL3103899) Show SMILES O=C1NC(=S)N\C1=C\c1cc2ccc(cc2[nH]1)-c1ccc2C(=O)NCCc2c1 Show InChI InChI=1S/C21H16N4O2S/c26-19-16-4-3-11(7-13(16)5-6-22-19)12-1-2-14-8-15(23-17(14)9-12)10-18-20(27)25-21(28)24-18/h1-4,7-10,23H,5-6H2,(H,22,26)(H2,24,25,27,28)/b18-10+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.66E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445306 (CHEMBL3104020) Show SMILES CC(=O)c1ccc(cc1)-c1ccc(C=C2NC(=S)NC2=O)s1 |w:13.13| Show InChI InChI=1S/C16H12N2O2S2/c1-9(19)10-2-4-11(5-3-10)14-7-6-12(22-14)8-13-15(20)18-16(21)17-13/h2-8H,1H3,(H2,17,18,20,21)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.67E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445308 (CHEMBL3104018) Show SMILES Brc1ccc(cc1)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C14H9BrN2OS2/c15-9-3-1-8(2-4-9)12-6-5-10(20-12)7-11-13(18)17-14(19)16-11/h1-7H,(H2,16,17,18,19)/b11-7+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.69E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445269 (CHEMBL3103645) Show SMILES CN1Cc2ccc(cc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C17H13N3O2S2/c1-20-8-10-3-2-9(6-12(10)16(20)22)14-5-4-11(24-14)7-13-15(21)19-17(23)18-13/h2-7H,8H2,1H3,(H2,18,19,21,23)/b13-7+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.89E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445266 (CHEMBL3103648) Show SMILES CN1CCc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C18H15N3O2S2/c1-21-7-6-10-8-11(2-4-13(10)17(21)23)15-5-3-12(25-15)9-14-16(22)20-18(24)19-14/h2-5,8-9H,6-7H2,1H3,(H2,19,20,22,24)/b14-9+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.33E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445288 (CHEMBL3103905) Show SMILES OCC(O)CNC(=O)c1ccc(cc1)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C18H17N3O4S2/c22-9-12(23)8-19-16(24)11-3-1-10(2-4-11)15-6-5-13(27-15)7-14-17(25)21-18(26)20-14/h1-7,12,22-23H,8-9H2,(H,19,24)(H2,20,21,25,26)/b14-7+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.44E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445257 (CHEMBL3103898) Show SMILES O=C1NC(=S)N\C1=C\c1cc2cc(ccc2[nH]1)-c1ccc2C(=O)NCc2c1 Show InChI InChI=1S/C20H14N4O2S/c25-18-15-3-1-10(6-13(15)9-21-18)11-2-4-16-12(5-11)7-14(22-16)8-17-19(26)24-20(27)23-17/h1-8,22H,9H2,(H,21,25)(H2,23,24,26,27)/b17-8+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445287 (CHEMBL3103906) Show SMILES O=C1NC(=S)N\C1=C\c1ccc(s1)-c1ccc2C(=O)NCc2c1 Show InChI InChI=1S/C16H11N3O2S2/c20-14-11-3-1-8(5-9(11)7-17-14)13-4-2-10(23-13)6-12-15(21)19-16(22)18-12/h1-6H,7H2,(H,17,20)(H2,18,19,21,22)/b12-6+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445254 (CHEMBL3103641) Show SMILES O=C1NC(=S)C(N1)=Cc1ccc2cc(ccc2n1)-c1ccc2C(=O)NCCc2c1 |w:7.8| Show InChI InChI=1S/C22H16N4O2S/c27-20-17-5-2-12(9-14(17)7-8-23-20)13-3-6-18-15(10-13)1-4-16(24-18)11-19-21(29)26-22(28)25-19/h1-6,9-11H,7-8H2,(H,23,27)(H2,25,26,28,29)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50347206 (CHEMBL1795762) Show SMILES Nc1c(C#N)c(-c2ccc(OCCO)cc2)c(C#N)c2nc3ccccc3n12 Show InChI InChI=1S/C21H15N5O2/c22-11-15-19(13-5-7-14(8-6-13)28-10-9-27)16(12-23)21-25-17-3-1-2-4-18(17)26(21)20(15)24/h1-8,27H,9-10,24H2	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.87E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin mediated lysis of human Jurkat cells pre-incubated for 30 mins with perforin followed by incubation with Jurkat ce...				Bioorg Med Chem 19: 4091-100 (2011) Article DOI: 10.1016/j.bmc.2011.05.013 BindingDB Entry DOI: 10.7270/Q2W66M48
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445262 (CHEMBL3103652) Show SMILES O=C1NC(=S)N\C1=C/c1cc(cs1)-c1ccc2C(=O)NCc2c1 Show InChI InChI=1S/C16H11N3O2S2/c20-14-12-2-1-8(3-9(12)6-17-14)10-4-11(23-7-10)5-13-15(21)19-16(22)18-13/h1-5,7H,6H2,(H,17,20)(H2,18,19,21,22)/b13-5-	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50347209 (CHEMBL1795769) Show SMILES NC(=O)c1ccc(cc1)-c1c(C#N)c(N)n2c(nc3ccccc23)c1C#N Show InChI InChI=1S/C20H12N6O/c21-9-13-17(11-5-7-12(8-6-11)19(24)27)14(10-22)20-25-15-3-1-2-4-16(15)26(20)18(13)23/h1-8H,23H2,(H2,24,27)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin mediated lysis of human Jurkat cells pre-incubated for 30 mins with perforin followed by incubation with Jurkat ce...				Bioorg Med Chem 19: 4091-100 (2011) Article DOI: 10.1016/j.bmc.2011.05.013 BindingDB Entry DOI: 10.7270/Q2W66M48
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445301 (CHEMBL3104024) Show SMILES COC(=O)c1ccc(cc1C)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C17H14N2O3S2/c1-9-7-10(3-5-12(9)16(21)22-2)14-6-4-11(24-14)8-13-15(20)19-17(23)18-13/h3-8H,1-2H3,(H2,18,19,20,23)/b13-8+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.03E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445305 (CHEMBL3104021) Show SMILES CC(=O)OCc1ccc(cc1)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C17H14N2O3S2/c1-10(20)22-9-11-2-4-12(5-3-11)15-7-6-13(24-15)8-14-16(21)19-17(23)18-14/h2-8H,9H2,1H3,(H2,18,19,21,23)/b14-8+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.04E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50347212 (CHEMBL1795772) Show SMILES Nc1c(C#N)c(-c2ccc(cc2)C(=O)NCCO)c(C#N)c2nc3ccccc3n12 Show InChI InChI=1S/C22H16N6O2/c23-11-15-19(13-5-7-14(8-6-13)22(30)26-9-10-29)16(12-24)21-27-17-3-1-2-4-18(17)28(21)20(15)25/h1-8,29H,9-10,25H2,(H,26,30)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.08E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin mediated lysis of human Jurkat cells pre-incubated for 30 mins with perforin followed by incubation with Jurkat ce...				Bioorg Med Chem 19: 4091-100 (2011) Article DOI: 10.1016/j.bmc.2011.05.013 BindingDB Entry DOI: 10.7270/Q2W66M48
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445309 (CHEMBL3104017) Show SMILES FC(F)(F)c1cc(ccc1Cl)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C15H8ClF3N2OS2/c16-10-3-1-7(5-9(10)15(17,18)19)12-4-2-8(24-12)6-11-13(22)21-14(23)20-11/h1-6H,(H2,20,21,22,23)/b11-6+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.09E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50347202 (CHEMBL1795771) Show SMILES CCNC(=O)c1ccc(cc1)-c1c(C#N)c(N)n2c3ccccc3nc2c1C#N Show InChI InChI=1S/C22H16N6O/c1-2-26-22(29)14-9-7-13(8-10-14)19-15(11-23)20(25)28-18-6-4-3-5-17(18)27-21(28)16(19)12-24/h3-10H,2,25H2,1H3,(H,26,29)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.16E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin mediated lysis of human Jurkat cells pre-incubated for 30 mins with perforin followed by incubation with Jurkat ce...				Bioorg Med Chem 19: 4091-100 (2011) Article DOI: 10.1016/j.bmc.2011.05.013 BindingDB Entry DOI: 10.7270/Q2W66M48
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445271 (CHEMBL3103643) Show SMILES CC1N(C)C(=O)c2ccc(cc12)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C18H15N3O2S2/c1-9-13-7-10(3-5-12(13)17(23)21(9)2)15-6-4-11(25-15)8-14-16(22)20-18(24)19-14/h3-9H,1-2H3,(H2,19,20,22,24)/b14-8+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.21E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50347214 (CHEMBL1795775) Show SMILES Nc1c(C#N)c(-c2ccc(cc2)C(=O)NCC(O)CO)c(C#N)c2nc3ccccc3n12 Show InChI InChI=1S/C23H18N6O3/c24-9-16-20(13-5-7-14(8-6-13)23(32)27-11-15(31)12-30)17(10-25)22-28-18-3-1-2-4-19(18)29(22)21(16)26/h1-8,15,30-31H,11-12,26H2,(H,27,32)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.24E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin mediated lysis of human Jurkat cells pre-incubated for 30 mins with perforin followed by incubation with Jurkat ce...				Bioorg Med Chem 19: 4091-100 (2011) Article DOI: 10.1016/j.bmc.2011.05.013 BindingDB Entry DOI: 10.7270/Q2W66M48
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445260 (CHEMBL3103654) Show SMILES O=C1NC(=S)N\C1=C/c1cccc(c1)-c1ccc2C(=O)NCc2c1 Show InChI InChI=1S/C18H13N3O2S/c22-16-14-5-4-12(8-13(14)9-19-16)11-3-1-2-10(6-11)7-15-17(23)21-18(24)20-15/h1-8H,9H2,(H,19,22)(H2,20,21,23,24)/b15-7-	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.44E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50347204 (CHEMBL1795784) Show SMILES Cc1cc2nc3c(C#N)c(-c4ccc(OCC(N)=O)cc4)c(C#N)c(N)n3c2cc1C Show InChI InChI=1S/C23H18N6O2/c1-12-7-18-19(8-13(12)2)29-22(27)16(9-24)21(17(10-25)23(29)28-18)14-3-5-15(6-4-14)31-11-20(26)30/h3-8H,11,27H2,1-2H3,(H2,26,30)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.53E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin mediated lysis of human Jurkat cells pre-incubated for 30 mins with perforin followed by incubation with Jurkat ce...				Bioorg Med Chem 19: 4091-100 (2011) Article DOI: 10.1016/j.bmc.2011.05.013 BindingDB Entry DOI: 10.7270/Q2W66M48
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445291 (CHEMBL3103902) Show SMILES OCCNC(=O)c1ccc(cc1)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C17H15N3O3S2/c21-8-7-18-15(22)11-3-1-10(2-4-11)14-6-5-12(25-14)9-13-16(23)20-17(24)19-13/h1-6,9,21H,7-8H2,(H,18,22)(H2,19,20,23,24)/b13-9+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.64E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50347207 (CHEMBL1795773) Show SMILES Nc1c(C#N)c(-c2ccc(cc2)C(=O)NCCCO)c(C#N)c2nc3ccccc3n12 Show InChI InChI=1S/C23H18N6O2/c24-12-16-20(14-6-8-15(9-7-14)23(31)27-10-3-11-30)17(13-25)22-28-18-4-1-2-5-19(18)29(22)21(16)26/h1-2,4-9,30H,3,10-11,26H2,(H,27,31)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.18E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin mediated lysis of human Jurkat cells pre-incubated for 30 mins with perforin followed by incubation with Jurkat ce...				Bioorg Med Chem 19: 4091-100 (2011) Article DOI: 10.1016/j.bmc.2011.05.013 BindingDB Entry DOI: 10.7270/Q2W66M48
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445290 (CHEMBL3103903) Show SMILES OCCCNC(=O)c1ccc(cc1)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C18H17N3O3S2/c22-9-1-8-19-16(23)12-4-2-11(3-5-12)15-7-6-13(26-15)10-14-17(24)21-18(25)20-14/h2-7,10,22H,1,8-9H2,(H,19,23)(H2,20,21,24,25)/b14-10+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.35E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445282 (CHEMBL3103911) Show SMILES CC(C)N1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C19H17N3O2S2/c1-10(2)22-9-12-7-11(3-5-14(12)18(22)24)16-6-4-13(26-16)8-15-17(23)21-19(25)20-15/h3-8,10H,9H2,1-2H3,(H2,20,21,23,25)/b15-8+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.42E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445296 (CHEMBL3104231) Show SMILES CNC(=O)c1ccc(cc1)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C16H13N3O2S2/c1-17-14(20)10-4-2-9(3-5-10)13-7-6-11(23-13)8-12-15(21)19-16(22)18-12/h2-8H,1H3,(H,17,20)(H2,18,19,21,22)/b12-8+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.53E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50347216 (CHEMBL1795350) Show SMILES CNC(=O)COc1ccc(cc1)-c1c(C#N)c(N)n2c3ccccc3nc2c1C#N Show InChI InChI=1S/C22H16N6O2/c1-26-19(29)12-30-14-8-6-13(7-9-14)20-15(10-23)21(25)28-18-5-3-2-4-17(18)27-22(28)16(20)11-24/h2-9H,12,25H2,1H3,(H,26,29)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.56E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin mediated lysis of human Jurkat cells pre-incubated for 30 mins with perforin followed by incubation with Jurkat ce...				Bioorg Med Chem 19: 4091-100 (2011) Article DOI: 10.1016/j.bmc.2011.05.013 BindingDB Entry DOI: 10.7270/Q2W66M48
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 105 total )  |  Next  |  Last  >>

Jump to: