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Compile Data Set for Download or QSAR

Found 543 hits with Last Name = 'min' and Initial = 'sj'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50098551
PNG
((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)
Show SMILES CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(O)c2)CC1 |r|
Show InChI InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18/h2,5-6,14-16,21H,3-4,7-13H2,1H3/t16-/m1/s1
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0.339n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50098551
PNG
((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)
Show SMILES CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(O)c2)CC1 |r|
Show InChI InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18/h2,5-6,14-16,21H,3-4,7-13H2,1H3/t16-/m1/s1
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0.340n/an/an/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of l...


Eur J Med Chem 123: 180-190 (2016)


Article DOI: 10.1016/j.ejmech.2016.07.029
BindingDB Entry DOI: 10.7270/Q27D2X36
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50098551
PNG
((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)
Show SMILES CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(O)c2)CC1 |r|
Show InChI InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18/h2,5-6,14-16,21H,3-4,7-13H2,1H3/t16-/m1/s1
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0.340n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
Translocator protein


(Homo sapiens (Human))
BDBM50159089
PNG
(CHEMBL180523 | N,N-Dibutyl-2-[6,8-dichloro-2-(4-ch...)
Show SMILES CCCCN(CCCC)C(=O)Cc1c(nc2c(Cl)cc(Cl)cn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H26Cl3N3O/c1-3-5-11-28(12-6-4-2)21(30)14-20-22(16-7-9-17(24)10-8-16)27-23-19(26)13-18(25)15-29(20)23/h7-10,13,15H,3-6,11-12,14H2,1-2H3
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2.70n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of TSPO (unknown origin)


Eur J Med Chem 125: 1172-1192 (2017)


Article DOI: 10.1016/j.ejmech.2016.11.017
BindingDB Entry DOI: 10.7270/Q25Q4Z83
More data for this
Ligand-Target Pair
Translocator protein


(Homo sapiens (Human))
BDBM50045877
PNG
(2-(2-(4-fluorophenyl)-1H-indol-3-yl)-N,N-dihexylac...)
Show SMILES CCCCCCN(CCCCCC)C(=O)Cc1c([nH]c2ccccc12)-c1ccc(F)cc1
Show InChI InChI=1S/C28H37FN2O/c1-3-5-7-11-19-31(20-12-8-6-4-2)27(32)21-25-24-13-9-10-14-26(24)30-28(25)22-15-17-23(29)18-16-22/h9-10,13-18,30H,3-8,11-12,19-21H2,1-2H3
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3.30n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of TSPO (unknown origin)


Eur J Med Chem 125: 1172-1192 (2017)


Article DOI: 10.1016/j.ejmech.2016.11.017
BindingDB Entry DOI: 10.7270/Q25Q4Z83
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50204672
PNG
(CHEMBL3961059)
Show SMILES CNCc1ccc(Cl)c(c1)-c1ccccc1OC
Show InChI InChI=1S/C15H16ClNO/c1-17-10-11-7-8-14(16)13(9-11)12-5-3-4-6-15(12)18-2/h3-9,17H,10H2,1-2H3
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5.20n/an/an/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of l...


Eur J Med Chem 123: 180-190 (2016)


Article DOI: 10.1016/j.ejmech.2016.07.029
BindingDB Entry DOI: 10.7270/Q27D2X36
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM10755
PNG
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
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6n/an/an/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of l...


Eur J Med Chem 123: 180-190 (2016)


Article DOI: 10.1016/j.ejmech.2016.07.029
BindingDB Entry DOI: 10.7270/Q27D2X36
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))
BDBM22032
PNG
(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...)
Show SMILES CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
Show InChI InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3
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8.90n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat cerebral cortex membranes after 60 mins by microbeta liquid scintillation counting method


Eur J Med Chem 125: 1172-1192 (2017)


Article DOI: 10.1016/j.ejmech.2016.11.017
BindingDB Entry DOI: 10.7270/Q25Q4Z83
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50204667
PNG
(CHEMBL3943658)
Show SMILES CNCc1ccc(C)c(c1)-c1ccccc1OC
Show InChI InChI=1S/C16H19NO/c1-12-8-9-13(11-17-2)10-15(12)14-6-4-5-7-16(14)18-3/h4-10,17H,11H2,1-3H3
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15n/an/an/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of l...


Eur J Med Chem 123: 180-190 (2016)


Article DOI: 10.1016/j.ejmech.2016.07.029
BindingDB Entry DOI: 10.7270/Q27D2X36
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50204668
PNG
(CHEMBL3928716)
Show SMILES COc1ccccc1N1CCN(Cc2cccc(c2)-c2ccccc2OC)CC1
Show InChI InChI=1S/C25H28N2O2/c1-28-24-12-5-3-10-22(24)21-9-7-8-20(18-21)19-26-14-16-27(17-15-26)23-11-4-6-13-25(23)29-2/h3-13,18H,14-17,19H2,1-2H3
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15n/an/an/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in CHO-K1 cell membranes incubated for 1.5 hrs in absence of l...


Eur J Med Chem 123: 180-190 (2016)


Article DOI: 10.1016/j.ejmech.2016.07.029
BindingDB Entry DOI: 10.7270/Q27D2X36
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50458557
PNG
(CHEMBL4215875)
Show SMILES Cc1ccc(cc1)-c1noc2CCNCCc12
Show InChI InChI=1S/C14H16N2O/c1-10-2-4-11(5-3-10)14-12-6-8-15-9-7-13(12)17-16-14/h2-5,15H,6-9H2,1H3
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16n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50458557
PNG
(CHEMBL4215875)
Show SMILES Cc1ccc(cc1)-c1noc2CCNCCc12
Show InChI InChI=1S/C14H16N2O/c1-10-2-4-11(5-3-10)14-12-6-8-15-9-7-13(12)17-16-14/h2-5,15H,6-9H2,1H3
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16n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50204674
PNG
(CHEMBL3892079)
Show SMILES COc1ccccc1N1CCN(Cc2ccc(C)c(c2)-c2ccccc2OC)CC1
Show InChI InChI=1S/C26H30N2O2/c1-20-12-13-21(18-23(20)22-8-4-6-10-25(22)29-2)19-27-14-16-28(17-15-27)24-9-5-7-11-26(24)30-3/h4-13,18H,14-17,19H2,1-3H3
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18n/an/an/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of l...


Eur J Med Chem 123: 180-190 (2016)


Article DOI: 10.1016/j.ejmech.2016.07.029
BindingDB Entry DOI: 10.7270/Q27D2X36
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50204678
PNG
(CHEMBL3931889)
Show SMILES COc1ccccc1-c1cc(CN(C)C)ccc1Cl
Show InChI InChI=1S/C16H18ClNO/c1-18(2)11-12-8-9-15(17)14(10-12)13-6-4-5-7-16(13)19-3/h4-10H,11H2,1-3H3
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18n/an/an/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of l...


Eur J Med Chem 123: 180-190 (2016)


Article DOI: 10.1016/j.ejmech.2016.07.029
BindingDB Entry DOI: 10.7270/Q27D2X36
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50458557
PNG
(CHEMBL4215875)
Show SMILES Cc1ccc(cc1)-c1noc2CCNCCc12
Show InChI InChI=1S/C14H16N2O/c1-10-2-4-11(5-3-10)14-12-6-8-15-9-7-13(12)17-16-14/h2-5,15H,6-9H2,1H3
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20n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT2C receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
Translocator protein


(Rattus norvegicus (rat))
BDBM50210940
PNG
(CHEMBL3948914)
Show SMILES CC(C)c1ccc(C)c(NC(=O)Cn2c(Cc3c(Cl)cccc3Cl)nc3ccccc23)c1
Show InChI InChI=1S/C26H25Cl2N3O/c1-16(2)18-12-11-17(3)23(13-18)30-26(32)15-31-24-10-5-4-9-22(24)29-25(31)14-19-20(27)7-6-8-21(19)28/h4-13,16H,14-15H2,1-3H3,(H,30,32)
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23n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat cerebral cortex membranes after 60 mins by microbeta liquid scintillation counting method


Eur J Med Chem 125: 1172-1192 (2017)


Article DOI: 10.1016/j.ejmech.2016.11.017
BindingDB Entry DOI: 10.7270/Q25Q4Z83
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50204677
PNG
(CHEMBL3901042)
Show SMILES COc1ccccc1-c1cc(CN(C)C)ccc1C
Show InChI InChI=1S/C17H21NO/c1-13-9-10-14(12-18(2)3)11-16(13)15-7-5-6-8-17(15)19-4/h5-11H,12H2,1-4H3
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23n/an/an/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of l...


Eur J Med Chem 123: 180-190 (2016)


Article DOI: 10.1016/j.ejmech.2016.07.029
BindingDB Entry DOI: 10.7270/Q27D2X36
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50458555
PNG
(CHEMBL4207884)
Show SMILES Clc1ccc(cc1)-c1n[nH]c2CCNCCc12
Show InChI InChI=1S/C13H14ClN3/c14-10-3-1-9(2-4-10)13-11-5-7-15-8-6-12(11)16-17-13/h1-4,15H,5-8H2,(H,16,17)
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30n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50458555
PNG
(CHEMBL4207884)
Show SMILES Clc1ccc(cc1)-c1n[nH]c2CCNCCc12
Show InChI InChI=1S/C13H14ClN3/c14-10-3-1-9(2-4-10)13-11-5-7-15-8-6-12(11)16-17-13/h1-4,15H,5-8H2,(H,16,17)
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32n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50204673
PNG
(CHEMBL3927929)
Show SMILES COc1ccccc1N1CCN(Cc2cc3OCOc3c(c2)-c2ccccc2OC)CC1
Show InChI InChI=1S/C26H28N2O4/c1-29-23-9-5-3-7-20(23)21-15-19(16-25-26(21)32-18-31-25)17-27-11-13-28(14-12-27)22-8-4-6-10-24(22)30-2/h3-10,15-16H,11-14,17-18H2,1-2H3
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34n/an/an/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of l...


Eur J Med Chem 123: 180-190 (2016)


Article DOI: 10.1016/j.ejmech.2016.07.029
BindingDB Entry DOI: 10.7270/Q27D2X36
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50458558
PNG
(CHEMBL4210782)
Show SMILES Cc1ccc(cc1)-c1n[nH]c2CCNCCc12
Show InChI InChI=1S/C14H17N3/c1-10-2-4-11(5-3-10)14-12-6-8-15-9-7-13(12)16-17-14/h2-5,15H,6-9H2,1H3,(H,16,17)
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47n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50458558
PNG
(CHEMBL4210782)
Show SMILES Cc1ccc(cc1)-c1n[nH]c2CCNCCc12
Show InChI InChI=1S/C14H17N3/c1-10-2-4-11(5-3-10)14-12-6-8-15-9-7-13(12)16-17-14/h2-5,15H,6-9H2,1H3,(H,16,17)
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47n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50458553
PNG
(CHEMBL4218672)
Show SMILES Fc1ccc(cc1)-c1noc2CCNCCc12
Show InChI InChI=1S/C13H13FN2O/c14-10-3-1-9(2-4-10)13-11-5-7-15-8-6-12(11)17-16-13/h1-4,15H,5-8H2
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52n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50458553
PNG
(CHEMBL4218672)
Show SMILES Fc1ccc(cc1)-c1noc2CCNCCc12
Show InChI InChI=1S/C13H13FN2O/c14-10-3-1-9(2-4-10)13-11-5-7-15-8-6-12(11)17-16-13/h1-4,15H,5-8H2
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53n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50458554
PNG
(CHEMBL4218801)
Show SMILES Clc1ccc(cc1)-c1noc2CCNCCc12
Show InChI InChI=1S/C13H13ClN2O/c14-10-3-1-9(2-4-10)13-11-5-7-15-8-6-12(11)17-16-13/h1-4,15H,5-8H2
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70n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50458554
PNG
(CHEMBL4218801)
Show SMILES Clc1ccc(cc1)-c1noc2CCNCCc12
Show InChI InChI=1S/C13H13ClN2O/c14-10-3-1-9(2-4-10)13-11-5-7-15-8-6-12(11)17-16-13/h1-4,15H,5-8H2
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71n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50204666
PNG
(CHEMBL3984812)
Show SMILES COc1ccccc1N1CCN(Cc2ccc(Cl)c(c2)-c2ccccc2OC)CC1
Show InChI InChI=1S/C25H27ClN2O2/c1-29-24-9-5-3-7-20(24)21-17-19(11-12-22(21)26)18-27-13-15-28(16-14-27)23-8-4-6-10-25(23)30-2/h3-12,17H,13-16,18H2,1-2H3
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73n/an/an/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of l...


Eur J Med Chem 123: 180-190 (2016)


Article DOI: 10.1016/j.ejmech.2016.07.029
BindingDB Entry DOI: 10.7270/Q27D2X36
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50204671
PNG
(CHEMBL3973160)
Show SMILES COc1ccccc1N1CCN(Cc2ccc(OC)c(c2)-c2ccccc2OC)CC1
Show InChI InChI=1S/C26H30N2O3/c1-29-24-10-6-4-8-21(24)22-18-20(12-13-25(22)30-2)19-27-14-16-28(17-15-27)23-9-5-7-11-26(23)31-3/h4-13,18H,14-17,19H2,1-3H3
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79n/an/an/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of l...


Eur J Med Chem 123: 180-190 (2016)


Article DOI: 10.1016/j.ejmech.2016.07.029
BindingDB Entry DOI: 10.7270/Q27D2X36
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM50458550
PNG
(CHEMBL4209274)
Show SMILES Fc1ccc(cc1)-c1n[nH]c2CCNCCc12
Show InChI InChI=1S/C13H14FN3/c14-10-3-1-9(2-4-10)13-11-5-7-15-8-6-12(11)16-17-13/h1-4,15H,5-8H2,(H,16,17)
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97n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM50458555
PNG
(CHEMBL4207884)
Show SMILES Clc1ccc(cc1)-c1n[nH]c2CCNCCc12
Show InChI InChI=1S/C13H14ClN3/c14-10-3-1-9(2-4-10)13-11-5-7-15-8-6-12(11)16-17-13/h1-4,15H,5-8H2,(H,16,17)
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100n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50458550
PNG
(CHEMBL4209274)
Show SMILES Fc1ccc(cc1)-c1n[nH]c2CCNCCc12
Show InChI InChI=1S/C13H14FN3/c14-10-3-1-9(2-4-10)13-11-5-7-15-8-6-12(11)16-17-13/h1-4,15H,5-8H2,(H,16,17)
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104n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50458550
PNG
(CHEMBL4209274)
Show SMILES Fc1ccc(cc1)-c1n[nH]c2CCNCCc12
Show InChI InChI=1S/C13H14FN3/c14-10-3-1-9(2-4-10)13-11-5-7-15-8-6-12(11)16-17-13/h1-4,15H,5-8H2,(H,16,17)
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105n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM50458558
PNG
(CHEMBL4210782)
Show SMILES Cc1ccc(cc1)-c1n[nH]c2CCNCCc12
Show InChI InChI=1S/C14H17N3/c1-10-2-4-11(5-3-10)14-12-6-8-15-9-7-13(12)16-17-14/h2-5,15H,6-9H2,1H3,(H,16,17)
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106n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50458558
PNG
(CHEMBL4210782)
Show SMILES Cc1ccc(cc1)-c1n[nH]c2CCNCCc12
Show InChI InChI=1S/C14H17N3/c1-10-2-4-11(5-3-10)14-12-6-8-15-9-7-13(12)16-17-14/h2-5,15H,6-9H2,1H3,(H,16,17)
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109n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT6 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50204670
PNG
(CHEMBL3918663)
Show SMILES COc1ccccc1-c1cccc(CN(C)C)c1
Show InChI InChI=1S/C16H19NO/c1-17(2)12-13-7-6-8-14(11-13)15-9-4-5-10-16(15)18-3/h4-11H,12H2,1-3H3
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126n/an/an/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of l...


Eur J Med Chem 123: 180-190 (2016)


Article DOI: 10.1016/j.ejmech.2016.07.029
BindingDB Entry DOI: 10.7270/Q27D2X36
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50458557
PNG
(CHEMBL4215875)
Show SMILES Cc1ccc(cc1)-c1noc2CCNCCc12
Show InChI InChI=1S/C14H16N2O/c1-10-2-4-11(5-3-10)14-12-6-8-15-9-7-13(12)17-16-14/h2-5,15H,6-9H2,1H3
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138n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT2A receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50458557
PNG
(CHEMBL4215875)
Show SMILES Cc1ccc(cc1)-c1noc2CCNCCc12
Show InChI InChI=1S/C14H16N2O/c1-10-2-4-11(5-3-10)14-12-6-8-15-9-7-13(12)17-16-14/h2-5,15H,6-9H2,1H3
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147n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT1D receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM50458557
PNG
(CHEMBL4215875)
Show SMILES Cc1ccc(cc1)-c1noc2CCNCCc12
Show InChI InChI=1S/C14H16N2O/c1-10-2-4-11(5-3-10)14-12-6-8-15-9-7-13(12)17-16-14/h2-5,15H,6-9H2,1H3
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150n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50458558
PNG
(CHEMBL4210782)
Show SMILES Cc1ccc(cc1)-c1n[nH]c2CCNCCc12
Show InChI InChI=1S/C14H17N3/c1-10-2-4-11(5-3-10)14-12-6-8-15-9-7-13(12)16-17-14/h2-5,15H,6-9H2,1H3,(H,16,17)
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159n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT2A receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50458558
PNG
(CHEMBL4210782)
Show SMILES Cc1ccc(cc1)-c1n[nH]c2CCNCCc12
Show InChI InChI=1S/C14H17N3/c1-10-2-4-11(5-3-10)14-12-6-8-15-9-7-13(12)16-17-14/h2-5,15H,6-9H2,1H3,(H,16,17)
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165n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT1D receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50458550
PNG
(CHEMBL4209274)
Show SMILES Fc1ccc(cc1)-c1n[nH]c2CCNCCc12
Show InChI InChI=1S/C13H14FN3/c14-10-3-1-9(2-4-10)13-11-5-7-15-8-6-12(11)16-17-13/h1-4,15H,5-8H2,(H,16,17)
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175n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT2A receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50458555
PNG
(CHEMBL4207884)
Show SMILES Clc1ccc(cc1)-c1n[nH]c2CCNCCc12
Show InChI InChI=1S/C13H14ClN3/c14-10-3-1-9(2-4-10)13-11-5-7-15-8-6-12(11)16-17-13/h1-4,15H,5-8H2,(H,16,17)
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187n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT2A receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50458550
PNG
(CHEMBL4209274)
Show SMILES Fc1ccc(cc1)-c1n[nH]c2CCNCCc12
Show InChI InChI=1S/C13H14FN3/c14-10-3-1-9(2-4-10)13-11-5-7-15-8-6-12(11)16-17-13/h1-4,15H,5-8H2,(H,16,17)
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200n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT2C receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50204679
PNG
(CHEMBL3952849)
Show SMILES CNCc1cccc(c1)-c1ccccc1OC
Show InChI InChI=1S/C15H17NO/c1-16-11-12-6-5-7-13(10-12)14-8-3-4-9-15(14)17-2/h3-10,16H,11H2,1-2H3
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226n/an/an/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of l...


Eur J Med Chem 123: 180-190 (2016)


Article DOI: 10.1016/j.ejmech.2016.07.029
BindingDB Entry DOI: 10.7270/Q27D2X36
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2B


(Homo sapiens (Human))
BDBM50458554
PNG
(CHEMBL4218801)
Show SMILES Clc1ccc(cc1)-c1noc2CCNCCc12
Show InChI InChI=1S/C13H13ClN2O/c14-10-3-1-9(2-4-10)13-11-5-7-15-8-6-12(11)17-16-13/h1-4,15H,5-8H2
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247n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50458555
PNG
(CHEMBL4207884)
Show SMILES Clc1ccc(cc1)-c1n[nH]c2CCNCCc12
Show InChI InChI=1S/C13H14ClN3/c14-10-3-1-9(2-4-10)13-11-5-7-15-8-6-12(11)16-17-13/h1-4,15H,5-8H2,(H,16,17)
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248n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT6 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50458558
PNG
(CHEMBL4210782)
Show SMILES Cc1ccc(cc1)-c1n[nH]c2CCNCCc12
Show InChI InChI=1S/C14H17N3/c1-10-2-4-11(5-3-10)14-12-6-8-15-9-7-13(12)16-17-14/h2-5,15H,6-9H2,1H3,(H,16,17)
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296n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT2C receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))
BDBM50458554
PNG
(CHEMBL4218801)
Show SMILES Clc1ccc(cc1)-c1noc2CCNCCc12
Show InChI InChI=1S/C13H13ClN2O/c14-10-3-1-9(2-4-10)13-11-5-7-15-8-6-12(11)17-16-13/h1-4,15H,5-8H2
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303n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT3 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50458562
PNG
(CHEMBL4215925)
Show SMILES C1Cc2onc(c2CCN1)-c1ccccc1
Show InChI InChI=1S/C13H14N2O/c1-2-4-10(5-3-1)13-11-6-8-14-9-7-12(11)16-15-13/h1-5,14H,6-9H2
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316n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50458562
PNG
(CHEMBL4215925)
Show SMILES C1Cc2onc(c2CCN1)-c1ccccc1
Show InChI InChI=1S/C13H14N2O/c1-2-4-10(5-3-1)13-11-6-8-14-9-7-12(11)16-15-13/h1-5,14H,6-9H2
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319n/an/an/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method


J Med Chem 61: 7218-7233 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00642
BindingDB Entry DOI: 10.7270/Q2BC424N
More data for this
Ligand-Target Pair
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