Found 174 hits with Last Name = 'samarakoon' and Initial = 't' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50177716
(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)Show SMILES FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1 Show InChI InChI=1S/C20H15ClF3N5/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Macrophage colony-stimulating factor 1 receptor [538-972]
(Homo sapiens (Human)) | BDBM181020
(US9133183, Example 29)Show SMILES Cc1nc(NC(=O)N2CCN(C3CCCC3)C2=O)ccc1Oc1ccnc(c1)-c1cnn(C)c1 Show InChI InChI=1S/C24H27N7O3/c1-16-21(34-19-9-10-25-20(13-19)17-14-26-29(2)15-17)7-8-22(27-16)28-23(32)31-12-11-30(24(31)33)18-5-3-4-6-18/h7-10,13-15,18H,3-6,11-12H2,1-2H3,(H,27,28,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Deciphera Pharmaceuticals, LLC
US Patent
| Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A... |
US Patent US9133183 (2015)
BindingDB Entry DOI: 10.7270/Q2DN43TD |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50589694
(CHEMBL5170451)Show SMILES COC(C)(C)C(=O)NC(=O)Nc1ccc(Oc2ccnc(c2)-c2cc(C)no2)c(C)n1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50589686
(CHEMBL5197168)Show SMILES Cc1nc(NC(=O)NC(=O)C2(C)CCOCC2)ccc1Oc1ccnc(c1)-c1cnn(C)c1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50589672
(CHEMBL5176985)Show SMILES Cn1cc(cn1)-c1cc(Oc2ccc(NC(=O)NC(=O)Cc3ccc(F)cc3)nc2)ccn1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor [538-972]
(Homo sapiens (Human)) | BDBM181019
(US9133183, Example 15)Show SMILES Cn1cc(cn1)-c1cc(Oc2ccc(NC(=O)N3CCN(C4CCCCC4)C3=O)nc2)ccn1 Show InChI InChI=1S/C24H27N7O3/c1-29-16-17(14-27-29)21-13-19(9-10-25-21)34-20-7-8-22(26-15-20)28-23(32)31-12-11-30(24(31)33)18-5-3-2-4-6-18/h7-10,13-16,18H,2-6,11-12H2,1H3,(H,26,28,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Deciphera Pharmaceuticals, LLC
US Patent
| Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A... |
US Patent US9133183 (2015)
BindingDB Entry DOI: 10.7270/Q2DN43TD |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50589678
(CHEMBL5181597)Show SMILES Cc1nc(NC(=O)NC(=O)C2CCC2)ccc1Oc1ccnc(c1)-c1cnn(C)c1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50589675
(CHEMBL5176270)Show SMILES Cc1nc(NC(=O)NC(=O)CC2CCCCC2)ccc1Oc1ccnc(c1)-c1cnn(C)c1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50589679
(CHEMBL5170039)Show SMILES Cc1nc(NC(=O)NC(=O)C2(C)CC2)ccc1Oc1ccnc(c1)-c1cnn(C)c1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50589674
(CHEMBL5186979)Show SMILES Cc1cc(NC(=O)NC(=O)Cc2ccc(F)cc2)ncc1Oc1ccnc(c1)-c1cnn(C)c1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50589677
(CHEMBL5174778)Show SMILES Cc1nc(NC(=O)NC(=O)C2CCCC2)ccc1Oc1ccnc(c1)-c1cnn(C)c1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50589676
(CHEMBL5177368)Show SMILES Cc1nc(NC(=O)NC(=O)C2CCCCC2)ccc1Oc1ccnc(c1)-c1cnn(C)c1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50589680
(CHEMBL5195204)Show SMILES Cc1nc(NC(=O)NC(=O)C(C)(C)C)ccc1Oc1ccnc(c1)-c1cnn(C)c1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor [538-972]
(Homo sapiens (Human)) | BDBM181027
(US9133183, Example 90)Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)N3CCN(C3=O)C(C)(C)C)nc2)ccn1 Show InChI InChI=1S/C20H24N6O4/c1-20(2,3)26-10-9-25(19(26)29)18(28)24-16-6-5-14(12-23-16)30-13-7-8-22-15(11-13)17(27)21-4/h5-8,11-12H,9-10H2,1-4H3,(H,21,27)(H,23,24,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Deciphera Pharmaceuticals, LLC
US Patent
| Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A... |
US Patent US9133183 (2015)
BindingDB Entry DOI: 10.7270/Q2DN43TD |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50589676
(CHEMBL5177368)Show SMILES Cc1nc(NC(=O)NC(=O)C2CCCCC2)ccc1Oc1ccnc(c1)-c1cnn(C)c1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50589675
(CHEMBL5176270)Show SMILES Cc1nc(NC(=O)NC(=O)CC2CCCCC2)ccc1Oc1ccnc(c1)-c1cnn(C)c1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50589681
(CHEMBL5194023)Show SMILES CC(C)C(=O)NC(=O)Nc1ccc(Oc2ccnc(c2)-c2cnn(C)c2)c(C)n1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor [538-972]
(Homo sapiens (Human)) | BDBM181018
(US9133183, Example 1)Show SMILES Cn1cc(cn1)-c1cc(Oc2ccc(NC(=O)N3CCN(C4CCOCC4)C3=O)nc2)ccn1 Show InChI InChI=1S/C23H25N7O4/c1-28-15-16(13-26-28)20-12-18(4-7-24-20)34-19-2-3-21(25-14-19)27-22(31)30-9-8-29(23(30)32)17-5-10-33-11-6-17/h2-4,7,12-15,17H,5-6,8-11H2,1H3,(H,25,27,31) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Deciphera Pharmaceuticals, LLC
US Patent
| Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A... |
US Patent US9133183 (2015)
BindingDB Entry DOI: 10.7270/Q2DN43TD |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50589689
(CHEMBL5170609)Show SMILES COC(C)(C)C(=O)NC(=O)Nc1ccc(Oc2ccnc(c2)-c2cnn(C)c2)c(C)n1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50589692
(CHEMBL5175832)Show SMILES COC(C)(C)C(=O)NC(=O)Nc1ccc(Oc2ccnc(c2)-c2ccnc(C)c2)c(C)n1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor [538-972]
(Homo sapiens (Human)) | BDBM181034
(US9133183, Example 91)Show SMILES Cn1cc(cn1)-c1cc(Oc2cc(F)c(NC(=O)N3CCN(C4CCOCC4)C3=O)cc2F)ccn1 Show InChI InChI=1S/C24H24F2N6O4/c1-30-14-15(13-28-30)20-10-17(2-5-27-20)36-22-12-18(25)21(11-19(22)26)29-23(33)32-7-6-31(24(32)34)16-3-8-35-9-4-16/h2,5,10-14,16H,3-4,6-9H2,1H3,(H,29,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Deciphera Pharmaceuticals, LLC
US Patent
| Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A... |
US Patent US9133183 (2015)
BindingDB Entry DOI: 10.7270/Q2DN43TD |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50177716
(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)Show SMILES FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1 Show InChI InChI=1S/C20H15ClF3N5/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50589687
(CHEMBL5191635)Show SMILES Cc1nc(NC(=O)NC(=O)C2CCOC2)ccc1Oc1ccnc(c1)-c1cnn(C)c1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50589688
(CHEMBL5176187)Show SMILES COC1(CC1)C(=O)NC(=O)Nc1ccc(Oc2ccnc(c2)-c2cnn(C)c2)c(C)n1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor [538-972]
(Homo sapiens (Human)) | BDBM181037
(US9133183, Example 42)Show SMILES CCN1CCN(C(=O)Nc2ccc(Oc3ccnc(c3)-c3cnn(C)c3)c(C)n2)C1=O Show InChI InChI=1S/C21H23N7O3/c1-4-27-9-10-28(21(27)30)20(29)25-19-6-5-18(14(2)24-19)31-16-7-8-22-17(11-16)15-12-23-26(3)13-15/h5-8,11-13H,4,9-10H2,1-3H3,(H,24,25,29) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Deciphera Pharmaceuticals, LLC
US Patent
| Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A... |
US Patent US9133183 (2015)
BindingDB Entry DOI: 10.7270/Q2DN43TD |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor [538-972]
(Homo sapiens (Human)) | BDBM181035
(US9133183, Example 101)Show SMILES CN(C)C(=O)Nc1cc(Oc2cc(F)c(NC(=O)N3CCN(C4CCOCC4)C3=O)cc2Cl)ccn1 Show InChI InChI=1S/C23H26ClFN6O5/c1-29(2)21(32)28-20-11-15(3-6-26-20)36-19-13-17(25)18(12-16(19)24)27-22(33)31-8-7-30(23(31)34)14-4-9-35-10-5-14/h3,6,11-14H,4-5,7-10H2,1-2H3,(H,27,33)(H,26,28,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Deciphera Pharmaceuticals, LLC
US Patent
| Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A... |
US Patent US9133183 (2015)
BindingDB Entry DOI: 10.7270/Q2DN43TD |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50589693
(CHEMBL5177523)Show SMILES COC(C)(C)C(=O)NC(=O)Nc1ccc(Oc2ccnc(c2)-c2cnc(C)s2)c(C)n1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50589673
(CHEMBL5197530)Show SMILES Cc1nc(NC(=O)NC(=O)Cc2ccc(F)cc2)ccc1Oc1ccnc(c1)-c1cnn(C)c1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50177716
(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)Show SMILES FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1 Show InChI InChI=1S/C20H15ClF3N5/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50589685
(CHEMBL5186614)Show SMILES Cc1nc(NC(=O)NC(=O)C2CCOCC2)ccc1Oc1ccnc(c1)-c1cnn(C)c1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50589672
(CHEMBL5176985)Show SMILES Cn1cc(cn1)-c1cc(Oc2ccc(NC(=O)NC(=O)Cc3ccc(F)cc3)nc2)ccn1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50589684
(CHEMBL5179072)Show SMILES Cc1nc(NC(=O)NC(=O)CC2CCOCC2)ccc1Oc1ccnc(c1)-c1cnn(C)c1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50589674
(CHEMBL5186979)Show SMILES Cc1cc(NC(=O)NC(=O)Cc2ccc(F)cc2)ncc1Oc1ccnc(c1)-c1cnn(C)c1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor [538-972]
(Homo sapiens (Human)) | BDBM181023
(US9133183, Compound A)Show SMILES Cn1cc(cn1)-c1cc(Oc2ccc(NC(=O)N3CCN(C3=O)c3ccc(F)cc3)nc2)ccn1 Show InChI InChI=1S/C24H20FN7O3/c1-30-15-16(13-28-30)21-12-19(8-9-26-21)35-20-6-7-22(27-14-20)29-23(33)32-11-10-31(24(32)34)18-4-2-17(25)3-5-18/h2-9,12-15H,10-11H2,1H3,(H,27,29,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Deciphera Pharmaceuticals, LLC
US Patent
| Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A... |
US Patent US9133183 (2015)
BindingDB Entry DOI: 10.7270/Q2DN43TD |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50589683
(CHEMBL5192531)Show SMILES CCc1nc(NC(=O)NC(=O)C(C)(C)C)ccc1Oc1ccnc(c1)-c1cnn(C)c1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50589671
(CHEMBL5190097)Show SMILES Cn1cc(cn1)-c1cc(Oc2ccc(NC(=O)NC(=O)Cc3ccc(F)cc3)cc2F)ccn1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor [538-972]
(Homo sapiens (Human)) | BDBM181026
(US9133183, Example 18)Show SMILES COCCN1CCN(C(=O)Nc2ccc(Oc3ccnc(c3)-c3cnn(C)c3)c(C)n2)C1=O Show InChI InChI=1S/C22H25N7O4/c1-15-19(33-17-6-7-23-18(12-17)16-13-24-27(2)14-16)4-5-20(25-15)26-21(30)29-9-8-28(22(29)31)10-11-32-3/h4-7,12-14H,8-11H2,1-3H3,(H,25,26,30) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Deciphera Pharmaceuticals, LLC
US Patent
| Assay Description
Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A... |
US Patent US9133183 (2015)
BindingDB Entry DOI: 10.7270/Q2DN43TD |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50589672
(CHEMBL5176985)Show SMILES Cn1cc(cn1)-c1cc(Oc2ccc(NC(=O)NC(=O)Cc3ccc(F)cc3)nc2)ccn1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50589691
(CHEMBL5202851)Show SMILES COC(C)(C)C(=O)NC(=O)Nc1ccc(Oc2ccnc(c2)-c2ccc(C)nc2)c(C)n1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50589674
(CHEMBL5186979)Show SMILES Cc1cc(NC(=O)NC(=O)Cc2ccc(F)cc2)ncc1Oc1ccnc(c1)-c1cnn(C)c1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50589671
(CHEMBL5190097)Show SMILES Cn1cc(cn1)-c1cc(Oc2ccc(NC(=O)NC(=O)Cc3ccc(F)cc3)cc2F)ccn1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50589676
(CHEMBL5177368)Show SMILES Cc1nc(NC(=O)NC(=O)C2CCCCC2)ccc1Oc1ccnc(c1)-c1cnn(C)c1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50589675
(CHEMBL5176270)Show SMILES Cc1nc(NC(=O)NC(=O)CC2CCCCC2)ccc1Oc1ccnc(c1)-c1cnn(C)c1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50589682
(CHEMBL5173244)Show SMILES CCC(=O)NC(=O)Nc1ccc(Oc2ccnc(c2)-c2cnn(C)c2)c(C)n1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50589671
(CHEMBL5190097)Show SMILES Cn1cc(cn1)-c1cc(Oc2ccc(NC(=O)NC(=O)Cc3ccc(F)cc3)cc2F)ccn1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50589677
(CHEMBL5174778)Show SMILES Cc1nc(NC(=O)NC(=O)C2CCCC2)ccc1Oc1ccnc(c1)-c1cnn(C)c1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50177716
(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)Show SMILES FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1 Show InChI InChI=1S/C20H15ClF3N5/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50589677
(CHEMBL5174778)Show SMILES Cc1nc(NC(=O)NC(=O)C2CCCC2)ccc1Oc1ccnc(c1)-c1cnn(C)c1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50589684
(CHEMBL5179072)Show SMILES Cc1nc(NC(=O)NC(=O)CC2CCOCC2)ccc1Oc1ccnc(c1)-c1cnn(C)c1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human)) | BDBM50589690
(CHEMBL5191854)Show SMILES COCC(=O)NC(=O)Nc1ccc(Oc2ccnc(c2)-c2cnn(C)c2)c(C)n1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 88 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128929
BindingDB Entry DOI: 10.7270/Q29W0KGP |
More data for this
Ligand-Target Pair | |
Search and Browse
