BindingDB PrimarySearch

Found 42 hits with Last Name = 'sarli' and Initial = 'v'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Sonic hedgehog protein (Mus musculus (Mouse))	BDBM50300863 (CHEMBL568011 \| N-(3-(1H-Benzo[d]imidazol-2-yl)-4-c...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	79.8	n/a	n/a	n/a	n/a	n/a	n/a
University of Leipzig Curated by ChEMBL					Assay Description Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG				Bioorg Med Chem 17: 4943-54 (2009) Article DOI: 10.1016/j.bmc.2009.06.008 BindingDB Entry DOI: 10.7270/Q2SJ1KPN
University of Leipzig Curated by ChEMBL					More data for this Ligand-Target Pair
Sonic hedgehog protein (Mus musculus (Mouse))	BDBM50249489 (CHEMBL514344 \| N-(3-(1H-Benzo[d]imidazol-2-yl)-4-c...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	97.9	n/a	n/a	n/a	n/a	n/a	n/a
University of Leipzig Curated by ChEMBL					Assay Description Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG				Bioorg Med Chem 17: 4943-54 (2009) Article DOI: 10.1016/j.bmc.2009.06.008 BindingDB Entry DOI: 10.7270/Q2SJ1KPN
University of Leipzig Curated by ChEMBL					More data for this Ligand-Target Pair
Sonic hedgehog protein (Mus musculus (Mouse))	BDBM50300862 (CHEMBL577049 \| N-(3-(1H-Benzo[d]imidazol-2-yl)-4-c...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	117	n/a	n/a	n/a	n/a	n/a	n/a
University of Leipzig Curated by ChEMBL					Assay Description Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG				Bioorg Med Chem 17: 4943-54 (2009) Article DOI: 10.1016/j.bmc.2009.06.008 BindingDB Entry DOI: 10.7270/Q2SJ1KPN
University of Leipzig Curated by ChEMBL					More data for this Ligand-Target Pair
Sonic hedgehog protein (Mus musculus (Mouse))	BDBM50300861 (CHEMBL567378 \| N-(3-(1H-Benzo[d]imidazol-2-yl)-4-c...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	119	n/a	n/a	n/a	n/a	n/a	n/a
University of Leipzig Curated by ChEMBL					Assay Description Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG				Bioorg Med Chem 17: 4943-54 (2009) Article DOI: 10.1016/j.bmc.2009.06.008 BindingDB Entry DOI: 10.7270/Q2SJ1KPN
University of Leipzig Curated by ChEMBL					More data for this Ligand-Target Pair
Integrin alpha-V/beta-3 (Homo sapiens (Human))	BDBM50585538 (CHEMBL5087579) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of alphavbeta3 integrin receptor-mediated cell adhesion to vitronectin in human A549 cells preincubated for 30 mins followed by VN substra...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01468 BindingDB Entry DOI: 10.7270/Q2SN0DVG
TBA					More data for this Ligand-Target Pair
Sonic hedgehog protein (Mus musculus (Mouse))	BDBM50300860 (CHEMBL579397 \| N-(3-(1H-Benzo[d]imidazol-2-yl)-4-c...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	163	n/a	n/a	n/a	n/a	n/a	n/a
University of Leipzig Curated by ChEMBL					Assay Description Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG				Bioorg Med Chem 17: 4943-54 (2009) Article DOI: 10.1016/j.bmc.2009.06.008 BindingDB Entry DOI: 10.7270/Q2SJ1KPN
University of Leipzig Curated by ChEMBL					More data for this Ligand-Target Pair
Sonic hedgehog protein (Mus musculus (Mouse))	BDBM50300859 (CHEMBL568022 \| N-(3-(1H-Benzo[d]imidazol-2-yl)-4-c...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	185	n/a	n/a	n/a	n/a	n/a	n/a
University of Leipzig Curated by ChEMBL					Assay Description Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG				Bioorg Med Chem 17: 4943-54 (2009) Article DOI: 10.1016/j.bmc.2009.06.008 BindingDB Entry DOI: 10.7270/Q2SJ1KPN
University of Leipzig Curated by ChEMBL					More data for this Ligand-Target Pair
Sonic hedgehog protein (Mus musculus (Mouse))	BDBM50300858 (CHEMBL584688 \| N-(3-(1H-Benzo[d]imidazol-2-yl)-4-c...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
University of Leipzig Curated by ChEMBL					Assay Description Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG				Bioorg Med Chem 17: 4943-54 (2009) Article DOI: 10.1016/j.bmc.2009.06.008 BindingDB Entry DOI: 10.7270/Q2SJ1KPN
University of Leipzig Curated by ChEMBL					More data for this Ligand-Target Pair
Integrin alpha-V/beta-3 (Homo sapiens (Human))	BDBM50585538 (CHEMBL5087579) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of alphavbeta3 integrin receptor-mediated cell adhesion to vitronectin in human WM 266-4 cells preincubated for 30 mins followed by VN sub...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01468 BindingDB Entry DOI: 10.7270/Q2SN0DVG
TBA					More data for this Ligand-Target Pair
Sonic hedgehog protein (Mus musculus (Mouse))	BDBM50300857 (CHEMBL565554 \| N-(3-(1H-Benzo[d]imidazol-2-yl)-4-c...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	224	n/a	n/a	n/a	n/a	n/a	n/a
University of Leipzig Curated by ChEMBL					Assay Description Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG				Bioorg Med Chem 17: 4943-54 (2009) Article DOI: 10.1016/j.bmc.2009.06.008 BindingDB Entry DOI: 10.7270/Q2SJ1KPN
University of Leipzig Curated by ChEMBL					More data for this Ligand-Target Pair
Sonic hedgehog protein (Mus musculus (Mouse))	BDBM50300856 (CHEMBL583230 \| N-(3-(1H-Benzo[d]imidazol-2-yl)-4-c...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	251	n/a	n/a	n/a	n/a	n/a	n/a
University of Leipzig Curated by ChEMBL					Assay Description Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG				Bioorg Med Chem 17: 4943-54 (2009) Article DOI: 10.1016/j.bmc.2009.06.008 BindingDB Entry DOI: 10.7270/Q2SJ1KPN
University of Leipzig Curated by ChEMBL					More data for this Ligand-Target Pair
Sonic hedgehog protein (Mus musculus (Mouse))	BDBM50300855 (CHEMBL578143 \| N-(3-(1H-Benzo[d]imidazol-2-yl)-4-c...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	876	n/a	n/a	n/a	n/a	n/a	n/a
University of Leipzig Curated by ChEMBL					Assay Description Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG				Bioorg Med Chem 17: 4943-54 (2009) Article DOI: 10.1016/j.bmc.2009.06.008 BindingDB Entry DOI: 10.7270/Q2SJ1KPN
University of Leipzig Curated by ChEMBL					More data for this Ligand-Target Pair
Kinesin-like protein KIF11 (Homo sapiens (Human))	BDBM84573 (VS-83) Show SMILES Oc1cccc(c1)C1NC(=S)Nc2cccc(F)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.17E+3	n/a	n/a	n/a	n/a	6.8	25
University of Leipzig					Assay Description The ATPase activity of the Eg5 motor domain was measured by using the malachite green assay.				Chembiochem 6: 2005-13 (2005) Article DOI: 10.1002/cbic.200500168 BindingDB Entry DOI: 10.7270/Q2XW4HB5
University of Leipzig					More data for this Ligand-Target Pair
Sonic hedgehog protein (Mus musculus (Mouse))	BDBM50232973 (CHEMBL254129 \| CYCLOPAMINE) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.31E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Leipzig Curated by ChEMBL					Assay Description Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG				Bioorg Med Chem 17: 4943-54 (2009) Article DOI: 10.1016/j.bmc.2009.06.008 BindingDB Entry DOI: 10.7270/Q2SJ1KPN
University of Leipzig Curated by ChEMBL					More data for this Ligand-Target Pair
Sonic hedgehog protein (Mus musculus (Mouse))	BDBM50300854 (CHEMBL583231 \| N-(3-(1H-Benzo[d]imidazol-2-yl)phen...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.33E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Leipzig Curated by ChEMBL					Assay Description Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG				Bioorg Med Chem 17: 4943-54 (2009) Article DOI: 10.1016/j.bmc.2009.06.008 BindingDB Entry DOI: 10.7270/Q2SJ1KPN
University of Leipzig Curated by ChEMBL					More data for this Ligand-Target Pair
Integrin alpha-V/beta-3 (Homo sapiens (Human))	BDBM50390492 (CHEMBL2071605) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of alphavbeta3 integrin receptor-mediated cell adhesion to vitronectin in human WM 266-4 cells preincubated for 30 mins followed by VN sub...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01468 BindingDB Entry DOI: 10.7270/Q2SN0DVG
TBA					More data for this Ligand-Target Pair
Kinesin-like protein KIF11 (Homo sapiens (Human))	BDBM84575 (VS-54) Show SMILES Oc1cccc(c1)C1NC(=S)Nc2cc(F)ccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.81E+3	n/a	n/a	n/a	n/a	6.8	25
University of Leipzig					Assay Description The ATPase activity of the Eg5 motor domain was measured by using the malachite green assay.				Chembiochem 6: 2005-13 (2005) Article DOI: 10.1002/cbic.200500168 BindingDB Entry DOI: 10.7270/Q2XW4HB5
University of Leipzig					More data for this Ligand-Target Pair
Kinesin-like protein KIF11 (Homo sapiens (Human))	BDBM84577 (VS-94) Show SMILES Cc1ccc2NC(=S)NC(c3cccc(O)c3)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.73E+3	n/a	n/a	n/a	n/a	6.8	25
University of Leipzig					Assay Description The ATPase activity of the Eg5 motor domain was measured by using the malachite green assay.				Chembiochem 6: 2005-13 (2005) Article DOI: 10.1002/cbic.200500168 BindingDB Entry DOI: 10.7270/Q2XW4HB5
University of Leipzig					More data for this Ligand-Target Pair
Kinesin-like protein KIF11 (Homo sapiens (Human))	BDBM84576 (VS-87) Show SMILES Oc1cccc(c1)C1NC(=S)Nc2cc(F)c(F)cc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.74E+3	n/a	n/a	n/a	n/a	6.8	25
University of Leipzig					Assay Description The ATPase activity of the Eg5 motor domain was measured by using the malachite green assay.				Chembiochem 6: 2005-13 (2005) Article DOI: 10.1002/cbic.200500168 BindingDB Entry DOI: 10.7270/Q2XW4HB5
University of Leipzig					More data for this Ligand-Target Pair
Low-density lipoprotein receptor-related protein 6 (Homo sapiens (Human))	BDBM50135174 (CHEMBL3747431) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotle University of Thessaloniki Curated by ChEMBL					Assay Description Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...				Bioorg Med Chem 24: 1014-22 (2016) Article DOI: 10.1016/j.bmc.2016.01.025 BindingDB Entry DOI: 10.7270/Q2J67JRS
Aristotle University of Thessaloniki Curated by ChEMBL					More data for this Ligand-Target Pair
Dickkopf-related protein 1 (Mus musculus)	BDBM50135174 (CHEMBL3747431) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotle University of Thessaloniki Curated by ChEMBL					Assay Description Inhibition of mouse DKK1 assessed as inhibition of DKK1-alkaline phophatase binding to LRP5 transfected in HEK293 cells				Eur J Med Chem 108: 28-38 (2016) Article DOI: 10.1016/j.ejmech.2015.11.024 BindingDB Entry DOI: 10.7270/Q2TF0067
Aristotle University of Thessaloniki Curated by ChEMBL					More data for this Ligand-Target Pair
Low-density lipoprotein receptor-related protein 6 (Homo sapiens (Human))	BDBM50145410 (CHEMBL3764819) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.38E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotle University of Thessaloniki Curated by ChEMBL					Assay Description Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...				Bioorg Med Chem 24: 1014-22 (2016) Article DOI: 10.1016/j.bmc.2016.01.025 BindingDB Entry DOI: 10.7270/Q2J67JRS
Aristotle University of Thessaloniki Curated by ChEMBL					More data for this Ligand-Target Pair
Low-density lipoprotein receptor-related protein 6 (Homo sapiens (Human))	BDBM50145403 (CHEMBL3764323) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.74E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotle University of Thessaloniki Curated by ChEMBL					Assay Description Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...				Bioorg Med Chem 24: 1014-22 (2016) Article DOI: 10.1016/j.bmc.2016.01.025 BindingDB Entry DOI: 10.7270/Q2J67JRS
Aristotle University of Thessaloniki Curated by ChEMBL					More data for this Ligand-Target Pair
Low-density lipoprotein receptor-related protein 6 (Homo sapiens (Human))	BDBM50145379 (CHEMBL3765769) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.77E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotle University of Thessaloniki Curated by ChEMBL					Assay Description Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...				Bioorg Med Chem 24: 1014-22 (2016) Article DOI: 10.1016/j.bmc.2016.01.025 BindingDB Entry DOI: 10.7270/Q2J67JRS
Aristotle University of Thessaloniki Curated by ChEMBL					More data for this Ligand-Target Pair
Low-density lipoprotein receptor-related protein 6 (Homo sapiens (Human))	BDBM50145384 (CHEMBL3764205) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.06E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotle University of Thessaloniki Curated by ChEMBL					Assay Description Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...				Bioorg Med Chem 24: 1014-22 (2016) Article DOI: 10.1016/j.bmc.2016.01.025 BindingDB Entry DOI: 10.7270/Q2J67JRS
Aristotle University of Thessaloniki Curated by ChEMBL					More data for this Ligand-Target Pair
Low-density lipoprotein receptor-related protein 6 (Homo sapiens (Human))	BDBM50145382 (CHEMBL3765415) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.33E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotle University of Thessaloniki Curated by ChEMBL					Assay Description Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...				Bioorg Med Chem 24: 1014-22 (2016) Article DOI: 10.1016/j.bmc.2016.01.025 BindingDB Entry DOI: 10.7270/Q2J67JRS
Aristotle University of Thessaloniki Curated by ChEMBL					More data for this Ligand-Target Pair
Low-density lipoprotein receptor-related protein 6 (Homo sapiens (Human))	BDBM50145409 (CHEMBL3765394) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.61E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotle University of Thessaloniki Curated by ChEMBL					Assay Description Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...				Bioorg Med Chem 24: 1014-22 (2016) Article DOI: 10.1016/j.bmc.2016.01.025 BindingDB Entry DOI: 10.7270/Q2J67JRS
Aristotle University of Thessaloniki Curated by ChEMBL					More data for this Ligand-Target Pair
Low-density lipoprotein receptor-related protein 6 (Homo sapiens (Human))	BDBM50145380 (CHEMBL3765591) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.71E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotle University of Thessaloniki Curated by ChEMBL					Assay Description Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...				Bioorg Med Chem 24: 1014-22 (2016) Article DOI: 10.1016/j.bmc.2016.01.025 BindingDB Entry DOI: 10.7270/Q2J67JRS
Aristotle University of Thessaloniki Curated by ChEMBL					More data for this Ligand-Target Pair
Low-density lipoprotein receptor-related protein 6 (Homo sapiens (Human))	BDBM50145381 (CHEMBL3763214) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.87E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotle University of Thessaloniki Curated by ChEMBL					Assay Description Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...				Bioorg Med Chem 24: 1014-22 (2016) Article DOI: 10.1016/j.bmc.2016.01.025 BindingDB Entry DOI: 10.7270/Q2J67JRS
Aristotle University of Thessaloniki Curated by ChEMBL					More data for this Ligand-Target Pair
Low-density lipoprotein receptor-related protein 6 (Homo sapiens (Human))	BDBM50145377 (CHEMBL3764713) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.23E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotle University of Thessaloniki Curated by ChEMBL					Assay Description Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...				Bioorg Med Chem 24: 1014-22 (2016) Article DOI: 10.1016/j.bmc.2016.01.025 BindingDB Entry DOI: 10.7270/Q2J67JRS
Aristotle University of Thessaloniki Curated by ChEMBL					More data for this Ligand-Target Pair
Low-density lipoprotein receptor-related protein 6 (Homo sapiens (Human))	BDBM50145383 (CHEMBL3763953) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotle University of Thessaloniki Curated by ChEMBL					Assay Description Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...				Bioorg Med Chem 24: 1014-22 (2016) Article DOI: 10.1016/j.bmc.2016.01.025 BindingDB Entry DOI: 10.7270/Q2J67JRS
Aristotle University of Thessaloniki Curated by ChEMBL					More data for this Ligand-Target Pair
Kinesin-like protein KIF11 (Homo sapiens (Human))	BDBM84578 (VS-17) Show SMILES Oc1cccc(c1)C1NC(=S)Nc2ccc(Br)cc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.75E+3	n/a	n/a	n/a	n/a	6.8	25
University of Leipzig					Assay Description The ATPase activity of the Eg5 motor domain was measured by using the malachite green assay.				Chembiochem 6: 2005-13 (2005) Article DOI: 10.1002/cbic.200500168 BindingDB Entry DOI: 10.7270/Q2XW4HB5
University of Leipzig					More data for this Ligand-Target Pair
Kinesin-like protein KIF11 (Homo sapiens (Human))	BDBM84572 (VS-42) Show SMILES Oc1cccc(c1)C1NC(=S)Nc2ccc(Cl)cc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.77E+3	n/a	n/a	n/a	n/a	6.8	25
University of Leipzig					Assay Description The ATPase activity of the Eg5 motor domain was measured by using the malachite green assay.				Chembiochem 6: 2005-13 (2005) Article DOI: 10.1002/cbic.200500168 BindingDB Entry DOI: 10.7270/Q2XW4HB5
University of Leipzig					More data for this Ligand-Target Pair
Low-density lipoprotein receptor-related protein 6 (Homo sapiens (Human))	BDBM50145378 (CHEMBL3764972) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.16E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotle University of Thessaloniki Curated by ChEMBL					Assay Description Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...				Bioorg Med Chem 24: 1014-22 (2016) Article DOI: 10.1016/j.bmc.2016.01.025 BindingDB Entry DOI: 10.7270/Q2J67JRS
Aristotle University of Thessaloniki Curated by ChEMBL					More data for this Ligand-Target Pair
Low-density lipoprotein receptor-related protein 6 (Homo sapiens (Human))	BDBM50135174 (CHEMBL3747431) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.38E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotle University of Thessaloniki Curated by ChEMBL					Assay Description Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...				Bioorg Med Chem 24: 1014-22 (2016) Article DOI: 10.1016/j.bmc.2016.01.025 BindingDB Entry DOI: 10.7270/Q2J67JRS
Aristotle University of Thessaloniki Curated by ChEMBL					More data for this Ligand-Target Pair
Kinesin-like protein KIF11 (Homo sapiens (Human))	BDBM84580 (VS-91) Show SMILES Cc1ccc2C(NC(=S)Nc2c1)c1cccc(O)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.59E+3	n/a	n/a	n/a	n/a	6.8	25
University of Leipzig					Assay Description The ATPase activity of the Eg5 motor domain was measured by using the malachite green assay.				Chembiochem 6: 2005-13 (2005) Article DOI: 10.1002/cbic.200500168 BindingDB Entry DOI: 10.7270/Q2XW4HB5
University of Leipzig					More data for this Ligand-Target Pair
Kinesin-like protein KIF11 (Homo sapiens (Human))	BDBM84574 (VS-12) Show SMILES Oc1cccc(c1)C1NC(=S)Nc2ccccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a	6.8	25
University of Leipzig					Assay Description The ATPase activity of the Eg5 motor domain was measured by using the malachite green assay.				Chembiochem 6: 2005-13 (2005) Article DOI: 10.1002/cbic.200500168 BindingDB Entry DOI: 10.7270/Q2XW4HB5
University of Leipzig					More data for this Ligand-Target Pair
Kinesin-like protein KIF11 (Homo sapiens (Human))	BDBM84579 (VS-77) Show SMILES Oc1cccc(c1)C1NC(=S)Nc2ccc(F)cc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.04E+3	n/a	n/a	n/a	n/a	6.8	25
University of Leipzig					Assay Description The ATPase activity of the Eg5 motor domain was measured by using the malachite green assay.				Chembiochem 6: 2005-13 (2005) Article DOI: 10.1002/cbic.200500168 BindingDB Entry DOI: 10.7270/Q2XW4HB5
University of Leipzig					More data for this Ligand-Target Pair
Integrin alpha-V/beta-3 (Homo sapiens (Human))	BDBM50585539 (CHEMBL5091463) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of alphavbeta3 integrin receptor-mediated cell adhesion to vitronectin in human WM 266-4 cells preincubated for 30 mins followed by VN sub...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01468 BindingDB Entry DOI: 10.7270/Q2SN0DVG
TBA					More data for this Ligand-Target Pair
Kinesin-like protein KIF11 (Homo sapiens (Human))	BDBM50198309 ((S)-4-(3-Hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	2.07E+4	n/a	n/a	n/a	n/a	6.8	25
University of Leipzig					Assay Description The ATPase activity of the Eg5 motor domain was measured by using the malachite green assay.				Chembiochem 6: 2005-13 (2005) Article DOI: 10.1002/cbic.200500168 BindingDB Entry DOI: 10.7270/Q2XW4HB5
University of Leipzig					More data for this Ligand-Target Pair				3D Structure (crystal)
Integrin alpha-V/beta-3 (Homo sapiens (Human))	BDBM50585539 (CHEMBL5091463) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of alphavbeta3 integrin receptor-mediated cell adhesion to vitronectin in human A549 cells preincubated for 30 mins followed by VN substra...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01468 BindingDB Entry DOI: 10.7270/Q2SN0DVG
TBA					More data for this Ligand-Target Pair
Integrin alpha-V/beta-3 (Homo sapiens (Human))	BDBM50390492 (CHEMBL2071605) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of alphavbeta3 integrin receptor-mediated cell adhesion to vitronectin in human A549 cells preincubated for 30 mins followed by VN substra...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01468 BindingDB Entry DOI: 10.7270/Q2SN0DVG
TBA					More data for this Ligand-Target Pair