Found 139 hits with Last Name = 'zoi' and Initial = 'i' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50250586
(CHEMBL4093140)Show SMILES CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)CN[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O |r| Show InChI InChI=1S/C78H113N21O18/c1-5-6-19-54(93-75(115)62(42-101)97-73(113)59(34-47-24-27-51(103)28-25-47)95-74(114)61(41-100)89-45(4)102)69(109)90-49(26-29-65(105)106)39-86-57(36-50-38-83-43-88-50)71(111)94-58(33-46-16-8-7-9-17-46)72(112)92-55(22-14-31-84-78(81)82)70(110)96-60(35-48-37-85-53-20-11-10-18-52(48)53)68(108)87-40-64(104)91-56(21-12-13-30-79)77(117)99-32-15-23-63(99)76(116)98-66(44(2)3)67(80)107/h7-11,16-18,20,24-25,27-28,37-38,43-44,49,54-63,66,85-86,100-101,103H,5-6,12-15,19,21-23,26,29-36,39-42,79H2,1-4H3,(H2,80,107)(H,83,88)(H,87,108)(H,89,102)(H,90,109)(H,91,104)(H,92,112)(H,93,115)(H,94,111)(H,95,114)(H,96,110)(H,97,113)(H,98,116)(H,105,106)(H4,81,82,84)/t49-,54-,55-,56-,57-,58+,59-,60-,61-,62-,63-,66-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.0100 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50134946
(CHEMBL2370964 | H-Tyr-Val-Nle-Gly-His-D-Nal(2')-Ar...)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |wU:68.72,8.22,90.96,wD:82.88,32.33,42.44,101.107,12.13,57.61,4.3,(2.47,-9.76,;1.17,-9.01,;1.19,-7.5,;-.16,-6.75,;-.14,-5.24,;-1.49,-4.47,;-2.84,-5.23,;-2.85,-6.73,;-4.17,-4.45,;-5.53,-5.2,;-6.86,-4.44,;-6.86,-2.92,;-8.22,-5.18,;-9.55,-4.42,;-8.24,-6.7,;-6.9,-7.44,;-5.56,-6.71,;-4.2,-7.47,;-4.23,-8.99,;-2.87,-9.75,;-5.57,-9.73,;-6.91,-8.97,;-4.17,-2.95,;-5.5,-2.19,;-2.82,-2.2,;1.2,-4.49,;1.22,-2.98,;2.54,-5.26,;3.9,-4.5,;5.23,-5.27,;5.21,-6.79,;6.58,-4.52,;7.92,-5.29,;7.92,-6.79,;9.25,-7.55,;10.69,-6.96,;11.71,-8.09,;10.92,-9.39,;9.41,-9.05,;9.28,-4.55,;9.3,-3.03,;10.61,-5.31,;11.96,-4.56,;11.96,-3.02,;11.17,-1.68,;9.62,-1.68,;8.85,-.34,;9.62,1.02,;8.85,2.36,;9.61,3.72,;11.17,3.72,;11.95,2.36,;11.17,1.02,;11.95,-.32,;13.31,-5.32,;13.29,-6.82,;14.65,-4.56,;15.99,-5.32,;15.98,-6.85,;17.32,-7.61,;17.3,-9.11,;18.65,-9.89,;18.63,-11.4,;19.98,-12.15,;17.29,-12.13,;17.35,-4.59,;17.36,-3.08,;18.69,-5.35,;20.05,-4.61,;20.05,-3.09,;21.4,-2.35,;22.81,-2.98,;23.86,-1.85,;23.1,-.55,;23.58,.89,;22.56,2.03,;21.03,1.71,;20.53,.28,;21.57,-.85,;21.37,-5.37,;21.37,-6.88,;22.73,-4.62,;24.06,-5.4,;24.06,-6.9,;25.41,-7.67,;26.74,-6.9,;25.39,-9.17,;25.41,-4.64,;25.43,-3.14,;26.76,-5.4,;28.12,-4.66,;28.13,-3.15,;29.48,-2.4,;29.48,-.89,;30.83,-.15,;30.84,1.36,;32.2,2.11,;29.51,2.12,;29.46,-5.43,;29.45,-6.93,;30.8,-4.67,;32.14,-5.44,;32.13,-6.95,;33.47,-7.71,;34.83,-6.96,;36.17,-7.72,;36.15,-9.24,;34.8,-9.99,;33.47,-9.22,;33.5,-4.69,;33.5,-3.19,;34.83,-5.46,;36.18,-4.72,;37.53,-5.48,;38.89,-4.73,;37.51,-6.99,)| Show InChI InChI=1S/C79H104N22O15/c1-4-5-20-56(96-77(116)67(44(2)3)101-68(107)54(80)33-46-25-28-52(102)29-26-46)69(108)91-42-65(104)93-62(37-51-40-86-43-92-51)75(114)98-60(35-47-24-27-48-17-9-10-18-49(48)32-47)73(112)94-58(23-14-31-88-79(84)85)72(111)99-61(36-50-39-89-55-21-12-11-19-53(50)55)74(113)100-63(38-66(105)106)76(115)95-57(22-13-30-87-78(82)83)71(110)97-59(70(109)90-41-64(81)103)34-45-15-7-6-8-16-45/h6-12,15-19,21,24-29,32,39-40,43-44,54,56-63,67,89,102H,4-5,13-14,20,22-23,30-31,33-38,41-42,80H2,1-3H3,(H2,81,103)(H,86,92)(H,90,109)(H,91,108)(H,93,104)(H,94,112)(H,95,115)(H,96,116)(H,97,110)(H,98,114)(H,99,111)(H,100,113)(H,101,107)(H,105,106)(H4,82,83,87)(H4,84,85,88)/t54-,56-,57-,58-,59-,60?,61-,62-,63-,67-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50250586
(CHEMBL4093140)Show SMILES CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)CN[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O |r| Show InChI InChI=1S/C78H113N21O18/c1-5-6-19-54(93-75(115)62(42-101)97-73(113)59(34-47-24-27-51(103)28-25-47)95-74(114)61(41-100)89-45(4)102)69(109)90-49(26-29-65(105)106)39-86-57(36-50-38-83-43-88-50)71(111)94-58(33-46-16-8-7-9-17-46)72(112)92-55(22-14-31-84-78(81)82)70(110)96-60(35-48-37-85-53-20-11-10-18-52(48)53)68(108)87-40-64(104)91-56(21-12-13-30-79)77(117)99-32-15-23-63(99)76(116)98-66(44(2)3)67(80)107/h7-11,16-18,20,24-25,27-28,37-38,43-44,49,54-63,66,85-86,100-101,103H,5-6,12-15,19,21-23,26,29-36,39-42,79H2,1-4H3,(H2,80,107)(H,83,88)(H,87,108)(H,89,102)(H,90,109)(H,91,104)(H,92,112)(H,93,115)(H,94,111)(H,95,114)(H,96,110)(H,97,113)(H,98,116)(H,105,106)(H4,81,82,84)/t49-,54-,55-,56-,57-,58+,59-,60-,61-,62-,63-,66-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50250591
(CHEMBL4072387)Show SMILES CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)CN[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O |r| Show InChI InChI=1S/C77H111N21O18S/c1-43(2)65(66(79)106)97-75(115)62-20-13-30-98(62)76(116)55(18-10-11-28-78)90-63(103)39-86-67(107)59(34-47-36-84-52-17-9-8-16-51(47)52)95-69(109)53(19-12-29-83-77(80)81)91-71(111)57(32-45-14-6-5-7-15-45)93-70(110)56(35-49-37-82-42-87-49)85-38-48(23-26-64(104)105)89-68(108)54(27-31-117-4)92-74(114)61(41-100)96-72(112)58(33-46-21-24-50(102)25-22-46)94-73(113)60(40-99)88-44(3)101/h5-9,14-17,21-22,24-25,36-37,42-43,48,53-62,65,84-85,99-100,102H,10-13,18-20,23,26-35,38-41,78H2,1-4H3,(H2,79,106)(H,82,87)(H,86,107)(H,88,101)(H,89,108)(H,90,103)(H,91,111)(H,92,114)(H,93,110)(H,94,113)(H,95,109)(H,96,112)(H,97,115)(H,104,105)(H4,80,81,83)/t48-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,65-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50250589
(CHEMBL4060000)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C74H101N17O15/c1-41(2)31-53(89-73(106)63(43(5)6)90-64(97)50(75)33-46-25-27-48(92)28-26-46)65(98)82-40-61(94)91-30-16-24-59(91)72(105)88-56(35-45-19-11-8-12-20-45)69(102)84-54(32-42(3)4)68(101)86-57(36-47-38-80-51-22-14-13-21-49(47)51)70(103)87-58(37-62(95)96)71(104)83-52(23-15-29-79-74(77)78)67(100)85-55(66(99)81-39-60(76)93)34-44-17-9-7-10-18-44/h7-14,17-22,25-28,38,41-43,50,52-59,63,80,92H,15-16,23-24,29-37,39-40,75H2,1-6H3,(H2,76,93)(H,81,99)(H,82,98)(H,83,104)(H,84,102)(H,85,100)(H,86,101)(H,87,103)(H,88,105)(H,89,106)(H,90,97)(H,95,96)(H4,77,78,79)/t50-,52-,53-,54-,55-,56-,57-,58-,59-,63-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.420 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50268806
(Ac-Tyr-Val-Nle-Gly-His-DPhe-Arg-Trp-Asp-Arg-Phe-Gl...)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |r,wU:12.21,56.58,35.35,81.85,45.46,4.4,100.104,wD:67.69,8.8,89.93,(6.82,-32.01,;5.49,-32.78,;5.49,-34.31,;4.16,-35.09,;4.16,-36.62,;2.82,-37.38,;1.49,-36.61,;1.49,-35.08,;.16,-37.38,;-1.17,-36.62,;-2.5,-37.4,;-2.5,-38.94,;-3.83,-36.63,;-3.83,-35.09,;-2.49,-34.32,;-1.16,-35.09,;.18,-34.32,;.18,-32.78,;1.51,-32,;-1.15,-32.01,;-2.49,-32.78,;-5.18,-37.37,;-6.51,-36.6,;-7.85,-37.37,;-6.51,-35.06,;.16,-38.93,;1.49,-39.69,;-1.18,-39.7,;5.49,-37.39,;5.49,-38.94,;6.83,-36.63,;8.16,-37.4,;9.49,-36.63,;9.49,-35.09,;10.83,-37.4,;12.17,-36.64,;12.17,-35.1,;13.5,-34.33,;14.91,-34.96,;15.95,-33.81,;15.17,-32.48,;13.66,-32.79,;13.5,-37.41,;13.5,-38.95,;14.83,-36.63,;16.17,-37.4,;16.17,-38.95,;17.5,-39.71,;18.84,-38.95,;20.17,-39.72,;20.17,-41.26,;18.83,-42.03,;17.5,-41.26,;17.5,-36.63,;17.5,-35.1,;18.83,-37.4,;20.18,-36.65,;20.18,-35.11,;21.51,-34.34,;21.51,-32.81,;22.84,-32.03,;22.85,-30.49,;21.51,-29.71,;24.18,-29.72,;21.51,-37.42,;21.51,-38.97,;22.84,-36.64,;24.17,-37.41,;24.17,-38.95,;25.5,-39.72,;26.91,-39.1,;27.94,-40.24,;27.17,-41.58,;27.64,-43.04,;26.61,-44.18,;25.1,-43.86,;24.63,-42.39,;25.66,-41.25,;25.5,-36.64,;25.5,-35.1,;26.84,-37.41,;28.17,-36.64,;28.17,-35.11,;29.5,-34.34,;30.83,-35.11,;29.5,-32.8,;29.5,-37.42,;29.5,-38.96,;30.84,-36.64,;32.17,-37.41,;32.17,-38.96,;33.49,-39.72,;33.49,-41.27,;34.82,-42.04,;34.83,-43.58,;33.49,-44.35,;36.16,-44.35,;33.49,-36.64,;33.49,-35.11,;34.83,-37.41,;36.16,-36.64,;36.16,-35.1,;37.5,-34.34,;38.83,-35.11,;40.16,-34.34,;40.17,-32.8,;38.84,-32.03,;37.5,-32.79,;37.5,-37.42,;37.5,-38.95,;38.83,-36.64,;40.16,-37.41,;41.48,-36.64,;42.83,-37.42,;41.48,-35.11,)| Show InChI InChI=1S/C77H104N22O16/c1-5-6-22-53(94-75(115)65(43(2)3)99-74(114)57(90-44(4)100)34-47-26-28-50(101)29-27-47)66(106)88-41-63(103)91-60(36-49-39-83-42-89-49)72(112)96-58(33-46-19-11-8-12-20-46)70(110)92-55(25-16-31-85-77(81)82)69(109)97-59(35-48-38-86-52-23-14-13-21-51(48)52)71(111)98-61(37-64(104)105)73(113)93-54(24-15-30-84-76(79)80)68(108)95-56(67(107)87-40-62(78)102)32-45-17-9-7-10-18-45/h7-14,17-21,23,26-29,38-39,42-43,53-61,65,86,101H,5-6,15-16,22,24-25,30-37,40-41H2,1-4H3,(H2,78,102)(H,83,89)(H,87,107)(H,88,106)(H,90,100)(H,91,103)(H,92,110)(H,93,113)(H,94,115)(H,95,108)(H,96,112)(H,97,109)(H,98,111)(H,99,114)(H,104,105)(H4,79,80,84)(H4,81,82,85)/t53-,54-,55-,56-,57-,58+,59-,60-,61-,65-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50027084
(Melatonan)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O |r| | PDB
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antibodypedia
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| Purchase
MCE
PC cid
PC sid
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| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Brussel
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC1 receptor expressed in HEK293 cells by gamma counting analysis |
ACS Med Chem Lett 6: 192-7 (2015)
Article DOI: 10.1021/ml500436s
BindingDB Entry DOI: 10.7270/Q24B330P |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50250590
(CHEMBL4081900)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C72H100N16O15/c1-41(2)32-51(86-71(103)61(43(5)6)87-62(94)49(73)34-47-26-28-48(89)29-27-47)63(95)79-40-59(91)88-31-17-25-57(88)70(102)85-55(37-46-22-14-9-15-23-46)68(100)81-52(33-42(3)4)66(98)83-54(36-45-20-12-8-13-21-45)67(99)84-56(38-60(92)93)69(101)80-50(24-16-30-77-72(75)76)65(97)82-53(64(96)78-39-58(74)90)35-44-18-10-7-11-19-44/h7-15,18-23,26-29,41-43,49-57,61,89H,16-17,24-25,30-40,73H2,1-6H3,(H2,74,90)(H,78,96)(H,79,95)(H,80,101)(H,81,100)(H,82,97)(H,83,98)(H,84,99)(H,85,102)(H,86,103)(H,87,94)(H,92,93)(H4,75,76,77)/t49-,50-,51-,52-,53-,54-,55-,56-,57-,61-/m0/s1 | PDB
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| Article
PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50250585
(CHEMBL4104092)Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C74H100N22O15S/c1-41(2)62(96-63(102)49(75)30-44-22-24-47(97)25-23-44)72(111)91-53(26-29-112-3)64(103)86-39-60(99)88-57(34-46-37-81-40-87-46)70(109)93-55(32-43-16-8-5-9-17-43)68(107)89-52(21-13-28-83-74(79)80)67(106)94-56(33-45-36-84-50-19-11-10-18-48(45)50)69(108)95-58(35-61(100)101)71(110)90-51(20-12-27-82-73(77)78)66(105)92-54(65(104)85-38-59(76)98)31-42-14-6-4-7-15-42/h4-11,14-19,22-25,36-37,40-41,49,51-58,62,84,97H,12-13,20-21,26-35,38-39,75H2,1-3H3,(H2,76,98)(H,81,87)(H,85,104)(H,86,103)(H,88,99)(H,89,107)(H,90,110)(H,91,111)(H,92,105)(H,93,109)(H,94,106)(H,95,108)(H,96,102)(H,100,101)(H4,77,78,82)(H4,79,80,83)/t49-,51-,52-,53-,54-,55-,56-,57-,58-,62-/m0/s1 | PDB
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PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50268806
(Ac-Tyr-Val-Nle-Gly-His-DPhe-Arg-Trp-Asp-Arg-Phe-Gl...)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |r,wU:12.21,56.58,35.35,81.85,45.46,4.4,100.104,wD:67.69,8.8,89.93,(6.82,-32.01,;5.49,-32.78,;5.49,-34.31,;4.16,-35.09,;4.16,-36.62,;2.82,-37.38,;1.49,-36.61,;1.49,-35.08,;.16,-37.38,;-1.17,-36.62,;-2.5,-37.4,;-2.5,-38.94,;-3.83,-36.63,;-3.83,-35.09,;-2.49,-34.32,;-1.16,-35.09,;.18,-34.32,;.18,-32.78,;1.51,-32,;-1.15,-32.01,;-2.49,-32.78,;-5.18,-37.37,;-6.51,-36.6,;-7.85,-37.37,;-6.51,-35.06,;.16,-38.93,;1.49,-39.69,;-1.18,-39.7,;5.49,-37.39,;5.49,-38.94,;6.83,-36.63,;8.16,-37.4,;9.49,-36.63,;9.49,-35.09,;10.83,-37.4,;12.17,-36.64,;12.17,-35.1,;13.5,-34.33,;14.91,-34.96,;15.95,-33.81,;15.17,-32.48,;13.66,-32.79,;13.5,-37.41,;13.5,-38.95,;14.83,-36.63,;16.17,-37.4,;16.17,-38.95,;17.5,-39.71,;18.84,-38.95,;20.17,-39.72,;20.17,-41.26,;18.83,-42.03,;17.5,-41.26,;17.5,-36.63,;17.5,-35.1,;18.83,-37.4,;20.18,-36.65,;20.18,-35.11,;21.51,-34.34,;21.51,-32.81,;22.84,-32.03,;22.85,-30.49,;21.51,-29.71,;24.18,-29.72,;21.51,-37.42,;21.51,-38.97,;22.84,-36.64,;24.17,-37.41,;24.17,-38.95,;25.5,-39.72,;26.91,-39.1,;27.94,-40.24,;27.17,-41.58,;27.64,-43.04,;26.61,-44.18,;25.1,-43.86,;24.63,-42.39,;25.66,-41.25,;25.5,-36.64,;25.5,-35.1,;26.84,-37.41,;28.17,-36.64,;28.17,-35.11,;29.5,-34.34,;30.83,-35.11,;29.5,-32.8,;29.5,-37.42,;29.5,-38.96,;30.84,-36.64,;32.17,-37.41,;32.17,-38.96,;33.49,-39.72,;33.49,-41.27,;34.82,-42.04,;34.83,-43.58,;33.49,-44.35,;36.16,-44.35,;33.49,-36.64,;33.49,-35.11,;34.83,-37.41,;36.16,-36.64,;36.16,-35.1,;37.5,-34.34,;38.83,-35.11,;40.16,-34.34,;40.17,-32.8,;38.84,-32.03,;37.5,-32.79,;37.5,-37.42,;37.5,-38.95,;38.83,-36.64,;40.16,-37.41,;41.48,-36.64,;42.83,-37.42,;41.48,-35.11,)| Show InChI InChI=1S/C77H104N22O16/c1-5-6-22-53(94-75(115)65(43(2)3)99-74(114)57(90-44(4)100)34-47-26-28-50(101)29-27-47)66(106)88-41-63(103)91-60(36-49-39-83-42-89-49)72(112)96-58(33-46-19-11-8-12-20-46)70(110)92-55(25-16-31-85-77(81)82)69(109)97-59(35-48-38-86-52-23-14-13-21-51(48)52)71(111)98-61(37-64(104)105)73(113)93-54(24-15-30-84-76(79)80)68(108)95-56(67(107)87-40-62(78)102)32-45-17-9-7-10-18-45/h7-14,17-21,23,26-29,38-39,42-43,53-61,65,86,101H,5-6,15-16,22,24-25,30-37,40-41H2,1-4H3,(H2,78,102)(H,83,89)(H,87,107)(H,88,106)(H,90,100)(H,91,103)(H,92,110)(H,93,113)(H,94,115)(H,95,108)(H,96,112)(H,97,109)(H,98,111)(H,99,114)(H,104,105)(H4,79,80,84)(H4,81,82,85)/t53-,54-,55-,56-,57-,58+,59-,60-,61-,65-/m0/s1 | PDB
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| Article
PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50268806
(Ac-Tyr-Val-Nle-Gly-His-DPhe-Arg-Trp-Asp-Arg-Phe-Gl...)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |r,wU:12.21,56.58,35.35,81.85,45.46,4.4,100.104,wD:67.69,8.8,89.93,(6.82,-32.01,;5.49,-32.78,;5.49,-34.31,;4.16,-35.09,;4.16,-36.62,;2.82,-37.38,;1.49,-36.61,;1.49,-35.08,;.16,-37.38,;-1.17,-36.62,;-2.5,-37.4,;-2.5,-38.94,;-3.83,-36.63,;-3.83,-35.09,;-2.49,-34.32,;-1.16,-35.09,;.18,-34.32,;.18,-32.78,;1.51,-32,;-1.15,-32.01,;-2.49,-32.78,;-5.18,-37.37,;-6.51,-36.6,;-7.85,-37.37,;-6.51,-35.06,;.16,-38.93,;1.49,-39.69,;-1.18,-39.7,;5.49,-37.39,;5.49,-38.94,;6.83,-36.63,;8.16,-37.4,;9.49,-36.63,;9.49,-35.09,;10.83,-37.4,;12.17,-36.64,;12.17,-35.1,;13.5,-34.33,;14.91,-34.96,;15.95,-33.81,;15.17,-32.48,;13.66,-32.79,;13.5,-37.41,;13.5,-38.95,;14.83,-36.63,;16.17,-37.4,;16.17,-38.95,;17.5,-39.71,;18.84,-38.95,;20.17,-39.72,;20.17,-41.26,;18.83,-42.03,;17.5,-41.26,;17.5,-36.63,;17.5,-35.1,;18.83,-37.4,;20.18,-36.65,;20.18,-35.11,;21.51,-34.34,;21.51,-32.81,;22.84,-32.03,;22.85,-30.49,;21.51,-29.71,;24.18,-29.72,;21.51,-37.42,;21.51,-38.97,;22.84,-36.64,;24.17,-37.41,;24.17,-38.95,;25.5,-39.72,;26.91,-39.1,;27.94,-40.24,;27.17,-41.58,;27.64,-43.04,;26.61,-44.18,;25.1,-43.86,;24.63,-42.39,;25.66,-41.25,;25.5,-36.64,;25.5,-35.1,;26.84,-37.41,;28.17,-36.64,;28.17,-35.11,;29.5,-34.34,;30.83,-35.11,;29.5,-32.8,;29.5,-37.42,;29.5,-38.96,;30.84,-36.64,;32.17,-37.41,;32.17,-38.96,;33.49,-39.72,;33.49,-41.27,;34.82,-42.04,;34.83,-43.58,;33.49,-44.35,;36.16,-44.35,;33.49,-36.64,;33.49,-35.11,;34.83,-37.41,;36.16,-36.64,;36.16,-35.1,;37.5,-34.34,;38.83,-35.11,;40.16,-34.34,;40.17,-32.8,;38.84,-32.03,;37.5,-32.79,;37.5,-37.42,;37.5,-38.95,;38.83,-36.64,;40.16,-37.41,;41.48,-36.64,;42.83,-37.42,;41.48,-35.11,)| Show InChI InChI=1S/C77H104N22O16/c1-5-6-22-53(94-75(115)65(43(2)3)99-74(114)57(90-44(4)100)34-47-26-28-50(101)29-27-47)66(106)88-41-63(103)91-60(36-49-39-83-42-89-49)72(112)96-58(33-46-19-11-8-12-20-46)70(110)92-55(25-16-31-85-77(81)82)69(109)97-59(35-48-38-86-52-23-14-13-21-51(48)52)71(111)98-61(37-64(104)105)73(113)93-54(24-15-30-84-76(79)80)68(108)95-56(67(107)87-40-62(78)102)32-45-17-9-7-10-18-45/h7-14,17-21,23,26-29,38-39,42-43,53-61,65,86,101H,5-6,15-16,22,24-25,30-37,40-41H2,1-4H3,(H2,78,102)(H,83,89)(H,87,107)(H,88,106)(H,90,100)(H,91,103)(H,92,110)(H,93,113)(H,94,115)(H,95,108)(H,96,112)(H,97,109)(H,98,111)(H,99,114)(H,104,105)(H4,79,80,84)(H4,81,82,85)/t53-,54-,55-,56-,57-,58+,59-,60-,61-,65-/m0/s1 | PDB
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| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50027084
(Melatonan)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O |r| | PDB
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| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Brussel
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells by gamma counting analysis |
ACS Med Chem Lett 6: 192-7 (2015)
Article DOI: 10.1021/ml500436s
BindingDB Entry DOI: 10.7270/Q24B330P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50250586
(CHEMBL4093140)Show SMILES CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)CN[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O |r| Show InChI InChI=1S/C78H113N21O18/c1-5-6-19-54(93-75(115)62(42-101)97-73(113)59(34-47-24-27-51(103)28-25-47)95-74(114)61(41-100)89-45(4)102)69(109)90-49(26-29-65(105)106)39-86-57(36-50-38-83-43-88-50)71(111)94-58(33-46-16-8-7-9-17-46)72(112)92-55(22-14-31-84-78(81)82)70(110)96-60(35-48-37-85-53-20-11-10-18-52(48)53)68(108)87-40-64(104)91-56(21-12-13-30-79)77(117)99-32-15-23-63(99)76(116)98-66(44(2)3)67(80)107/h7-11,16-18,20,24-25,27-28,37-38,43-44,49,54-63,66,85-86,100-101,103H,5-6,12-15,19,21-23,26,29-36,39-42,79H2,1-4H3,(H2,80,107)(H,83,88)(H,87,108)(H,89,102)(H,90,109)(H,91,104)(H,92,112)(H,93,115)(H,94,111)(H,95,114)(H,96,110)(H,97,113)(H,98,116)(H,105,106)(H4,81,82,84)/t49-,54-,55-,56-,57-,58+,59-,60-,61-,62-,63-,66-/m0/s1 | PDB
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| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50027084
(Melatonan)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O |r| | PDB
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| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Brussel
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC4 receptor expressed in HEK293 cells by gamma counting analysis |
ACS Med Chem Lett 6: 192-7 (2015)
Article DOI: 10.1021/ml500436s
BindingDB Entry DOI: 10.7270/Q24B330P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50268806
(Ac-Tyr-Val-Nle-Gly-His-DPhe-Arg-Trp-Asp-Arg-Phe-Gl...)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |r,wU:12.21,56.58,35.35,81.85,45.46,4.4,100.104,wD:67.69,8.8,89.93,(6.82,-32.01,;5.49,-32.78,;5.49,-34.31,;4.16,-35.09,;4.16,-36.62,;2.82,-37.38,;1.49,-36.61,;1.49,-35.08,;.16,-37.38,;-1.17,-36.62,;-2.5,-37.4,;-2.5,-38.94,;-3.83,-36.63,;-3.83,-35.09,;-2.49,-34.32,;-1.16,-35.09,;.18,-34.32,;.18,-32.78,;1.51,-32,;-1.15,-32.01,;-2.49,-32.78,;-5.18,-37.37,;-6.51,-36.6,;-7.85,-37.37,;-6.51,-35.06,;.16,-38.93,;1.49,-39.69,;-1.18,-39.7,;5.49,-37.39,;5.49,-38.94,;6.83,-36.63,;8.16,-37.4,;9.49,-36.63,;9.49,-35.09,;10.83,-37.4,;12.17,-36.64,;12.17,-35.1,;13.5,-34.33,;14.91,-34.96,;15.95,-33.81,;15.17,-32.48,;13.66,-32.79,;13.5,-37.41,;13.5,-38.95,;14.83,-36.63,;16.17,-37.4,;16.17,-38.95,;17.5,-39.71,;18.84,-38.95,;20.17,-39.72,;20.17,-41.26,;18.83,-42.03,;17.5,-41.26,;17.5,-36.63,;17.5,-35.1,;18.83,-37.4,;20.18,-36.65,;20.18,-35.11,;21.51,-34.34,;21.51,-32.81,;22.84,-32.03,;22.85,-30.49,;21.51,-29.71,;24.18,-29.72,;21.51,-37.42,;21.51,-38.97,;22.84,-36.64,;24.17,-37.41,;24.17,-38.95,;25.5,-39.72,;26.91,-39.1,;27.94,-40.24,;27.17,-41.58,;27.64,-43.04,;26.61,-44.18,;25.1,-43.86,;24.63,-42.39,;25.66,-41.25,;25.5,-36.64,;25.5,-35.1,;26.84,-37.41,;28.17,-36.64,;28.17,-35.11,;29.5,-34.34,;30.83,-35.11,;29.5,-32.8,;29.5,-37.42,;29.5,-38.96,;30.84,-36.64,;32.17,-37.41,;32.17,-38.96,;33.49,-39.72,;33.49,-41.27,;34.82,-42.04,;34.83,-43.58,;33.49,-44.35,;36.16,-44.35,;33.49,-36.64,;33.49,-35.11,;34.83,-37.41,;36.16,-36.64,;36.16,-35.1,;37.5,-34.34,;38.83,-35.11,;40.16,-34.34,;40.17,-32.8,;38.84,-32.03,;37.5,-32.79,;37.5,-37.42,;37.5,-38.95,;38.83,-36.64,;40.16,-37.41,;41.48,-36.64,;42.83,-37.42,;41.48,-35.11,)| Show InChI InChI=1S/C77H104N22O16/c1-5-6-22-53(94-75(115)65(43(2)3)99-74(114)57(90-44(4)100)34-47-26-28-50(101)29-27-47)66(106)88-41-63(103)91-60(36-49-39-83-42-89-49)72(112)96-58(33-46-19-11-8-12-20-46)70(110)92-55(25-16-31-85-77(81)82)69(109)97-59(35-48-38-86-52-23-14-13-21-51(48)52)71(111)98-61(37-64(104)105)73(113)93-54(24-15-30-84-76(79)80)68(108)95-56(67(107)87-40-62(78)102)32-45-17-9-7-10-18-45/h7-14,17-21,23,26-29,38-39,42-43,53-61,65,86,101H,5-6,15-16,22,24-25,30-37,40-41H2,1-4H3,(H2,78,102)(H,83,89)(H,87,107)(H,88,106)(H,90,100)(H,91,103)(H,92,110)(H,93,113)(H,94,115)(H,95,108)(H,96,112)(H,97,109)(H,98,111)(H,99,114)(H,104,105)(H4,79,80,84)(H4,81,82,85)/t53-,54-,55-,56-,57-,58+,59-,60-,61-,65-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50250586
(CHEMBL4093140)Show SMILES CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)CN[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O |r| Show InChI InChI=1S/C78H113N21O18/c1-5-6-19-54(93-75(115)62(42-101)97-73(113)59(34-47-24-27-51(103)28-25-47)95-74(114)61(41-100)89-45(4)102)69(109)90-49(26-29-65(105)106)39-86-57(36-50-38-83-43-88-50)71(111)94-58(33-46-16-8-7-9-17-46)72(112)92-55(22-14-31-84-78(81)82)70(110)96-60(35-48-37-85-53-20-11-10-18-52(48)53)68(108)87-40-64(104)91-56(21-12-13-30-79)77(117)99-32-15-23-63(99)76(116)98-66(44(2)3)67(80)107/h7-11,16-18,20,24-25,27-28,37-38,43-44,49,54-63,66,85-86,100-101,103H,5-6,12-15,19,21-23,26,29-36,39-42,79H2,1-4H3,(H2,80,107)(H,83,88)(H,87,108)(H,89,102)(H,90,109)(H,91,104)(H,92,112)(H,93,115)(H,94,111)(H,95,114)(H,96,110)(H,97,113)(H,98,116)(H,105,106)(H4,81,82,84)/t49-,54-,55-,56-,57-,58+,59-,60-,61-,62-,63-,66-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50134946
(CHEMBL2370964 | H-Tyr-Val-Nle-Gly-His-D-Nal(2')-Ar...)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |wU:68.72,8.22,90.96,wD:82.88,32.33,42.44,101.107,12.13,57.61,4.3,(2.47,-9.76,;1.17,-9.01,;1.19,-7.5,;-.16,-6.75,;-.14,-5.24,;-1.49,-4.47,;-2.84,-5.23,;-2.85,-6.73,;-4.17,-4.45,;-5.53,-5.2,;-6.86,-4.44,;-6.86,-2.92,;-8.22,-5.18,;-9.55,-4.42,;-8.24,-6.7,;-6.9,-7.44,;-5.56,-6.71,;-4.2,-7.47,;-4.23,-8.99,;-2.87,-9.75,;-5.57,-9.73,;-6.91,-8.97,;-4.17,-2.95,;-5.5,-2.19,;-2.82,-2.2,;1.2,-4.49,;1.22,-2.98,;2.54,-5.26,;3.9,-4.5,;5.23,-5.27,;5.21,-6.79,;6.58,-4.52,;7.92,-5.29,;7.92,-6.79,;9.25,-7.55,;10.69,-6.96,;11.71,-8.09,;10.92,-9.39,;9.41,-9.05,;9.28,-4.55,;9.3,-3.03,;10.61,-5.31,;11.96,-4.56,;11.96,-3.02,;11.17,-1.68,;9.62,-1.68,;8.85,-.34,;9.62,1.02,;8.85,2.36,;9.61,3.72,;11.17,3.72,;11.95,2.36,;11.17,1.02,;11.95,-.32,;13.31,-5.32,;13.29,-6.82,;14.65,-4.56,;15.99,-5.32,;15.98,-6.85,;17.32,-7.61,;17.3,-9.11,;18.65,-9.89,;18.63,-11.4,;19.98,-12.15,;17.29,-12.13,;17.35,-4.59,;17.36,-3.08,;18.69,-5.35,;20.05,-4.61,;20.05,-3.09,;21.4,-2.35,;22.81,-2.98,;23.86,-1.85,;23.1,-.55,;23.58,.89,;22.56,2.03,;21.03,1.71,;20.53,.28,;21.57,-.85,;21.37,-5.37,;21.37,-6.88,;22.73,-4.62,;24.06,-5.4,;24.06,-6.9,;25.41,-7.67,;26.74,-6.9,;25.39,-9.17,;25.41,-4.64,;25.43,-3.14,;26.76,-5.4,;28.12,-4.66,;28.13,-3.15,;29.48,-2.4,;29.48,-.89,;30.83,-.15,;30.84,1.36,;32.2,2.11,;29.51,2.12,;29.46,-5.43,;29.45,-6.93,;30.8,-4.67,;32.14,-5.44,;32.13,-6.95,;33.47,-7.71,;34.83,-6.96,;36.17,-7.72,;36.15,-9.24,;34.8,-9.99,;33.47,-9.22,;33.5,-4.69,;33.5,-3.19,;34.83,-5.46,;36.18,-4.72,;37.53,-5.48,;38.89,-4.73,;37.51,-6.99,)| Show InChI InChI=1S/C79H104N22O15/c1-4-5-20-56(96-77(116)67(44(2)3)101-68(107)54(80)33-46-25-28-52(102)29-26-46)69(108)91-42-65(104)93-62(37-51-40-86-43-92-51)75(114)98-60(35-47-24-27-48-17-9-10-18-49(48)32-47)73(112)94-58(23-14-31-88-79(84)85)72(111)99-61(36-50-39-89-55-21-12-11-19-53(50)55)74(113)100-63(38-66(105)106)76(115)95-57(22-13-30-87-78(82)83)71(110)97-59(70(109)90-41-64(81)103)34-45-15-7-6-8-16-45/h6-12,15-19,21,24-29,32,39-40,43-44,54,56-63,67,89,102H,4-5,13-14,20,22-23,30-31,33-38,41-42,80H2,1-3H3,(H2,81,103)(H,86,92)(H,90,109)(H,91,108)(H,93,104)(H,94,112)(H,95,115)(H,96,116)(H,97,110)(H,98,114)(H,99,111)(H,100,113)(H,101,107)(H,105,106)(H4,82,83,87)(H4,84,85,88)/t54-,56-,57-,58-,59-,60?,61-,62-,63-,67-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50250587
(CHEMBL4079302)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C74H102N20O15/c1-41(2)32-53(92-72(109)62(42(3)4)93-63(100)49(75)33-45-25-27-47(95)28-26-45)64(101)85-40-60(97)94-31-15-24-58(94)71(108)91-55(35-44-18-9-6-10-19-44)68(105)86-52(23-14-30-82-74(79)80)67(104)89-56(36-46-38-83-50-21-12-11-20-48(46)50)69(106)90-57(37-61(98)99)70(107)87-51(22-13-29-81-73(77)78)66(103)88-54(65(102)84-39-59(76)96)34-43-16-7-5-8-17-43/h5-12,16-21,25-28,38,41-42,49,51-58,62,83,95H,13-15,22-24,29-37,39-40,75H2,1-4H3,(H2,76,96)(H,84,102)(H,85,101)(H,86,105)(H,87,107)(H,88,103)(H,89,104)(H,90,106)(H,91,108)(H,92,109)(H,93,100)(H,98,99)(H4,77,78,81)(H4,79,80,82)/t49-,51-,52-,53-,54-,55-,56-,57-,58-,62-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50027084
(Melatonan)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O |r| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Brussel
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysis |
ACS Med Chem Lett 6: 192-7 (2015)
Article DOI: 10.1021/ml500436s
BindingDB Entry DOI: 10.7270/Q24B330P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50250587
(CHEMBL4079302)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C74H102N20O15/c1-41(2)32-53(92-72(109)62(42(3)4)93-63(100)49(75)33-45-25-27-47(95)28-26-45)64(101)85-40-60(97)94-31-15-24-58(94)71(108)91-55(35-44-18-9-6-10-19-44)68(105)86-52(23-14-30-82-74(79)80)67(104)89-56(36-46-38-83-50-21-12-11-20-48(46)50)69(106)90-57(37-61(98)99)70(107)87-51(22-13-29-81-73(77)78)66(103)88-54(65(102)84-39-59(76)96)34-43-16-7-5-8-17-43/h5-12,16-21,25-28,38,41-42,49,51-58,62,83,95H,13-15,22-24,29-37,39-40,75H2,1-4H3,(H2,76,96)(H,84,102)(H,85,101)(H,86,105)(H,87,107)(H,88,103)(H,89,104)(H,90,106)(H,91,108)(H,92,109)(H,93,100)(H,98,99)(H4,77,78,81)(H4,79,80,82)/t49-,51-,52-,53-,54-,55-,56-,57-,58-,62-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50134946
(CHEMBL2370964 | H-Tyr-Val-Nle-Gly-His-D-Nal(2')-Ar...)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |wU:68.72,8.22,90.96,wD:82.88,32.33,42.44,101.107,12.13,57.61,4.3,(2.47,-9.76,;1.17,-9.01,;1.19,-7.5,;-.16,-6.75,;-.14,-5.24,;-1.49,-4.47,;-2.84,-5.23,;-2.85,-6.73,;-4.17,-4.45,;-5.53,-5.2,;-6.86,-4.44,;-6.86,-2.92,;-8.22,-5.18,;-9.55,-4.42,;-8.24,-6.7,;-6.9,-7.44,;-5.56,-6.71,;-4.2,-7.47,;-4.23,-8.99,;-2.87,-9.75,;-5.57,-9.73,;-6.91,-8.97,;-4.17,-2.95,;-5.5,-2.19,;-2.82,-2.2,;1.2,-4.49,;1.22,-2.98,;2.54,-5.26,;3.9,-4.5,;5.23,-5.27,;5.21,-6.79,;6.58,-4.52,;7.92,-5.29,;7.92,-6.79,;9.25,-7.55,;10.69,-6.96,;11.71,-8.09,;10.92,-9.39,;9.41,-9.05,;9.28,-4.55,;9.3,-3.03,;10.61,-5.31,;11.96,-4.56,;11.96,-3.02,;11.17,-1.68,;9.62,-1.68,;8.85,-.34,;9.62,1.02,;8.85,2.36,;9.61,3.72,;11.17,3.72,;11.95,2.36,;11.17,1.02,;11.95,-.32,;13.31,-5.32,;13.29,-6.82,;14.65,-4.56,;15.99,-5.32,;15.98,-6.85,;17.32,-7.61,;17.3,-9.11,;18.65,-9.89,;18.63,-11.4,;19.98,-12.15,;17.29,-12.13,;17.35,-4.59,;17.36,-3.08,;18.69,-5.35,;20.05,-4.61,;20.05,-3.09,;21.4,-2.35,;22.81,-2.98,;23.86,-1.85,;23.1,-.55,;23.58,.89,;22.56,2.03,;21.03,1.71,;20.53,.28,;21.57,-.85,;21.37,-5.37,;21.37,-6.88,;22.73,-4.62,;24.06,-5.4,;24.06,-6.9,;25.41,-7.67,;26.74,-6.9,;25.39,-9.17,;25.41,-4.64,;25.43,-3.14,;26.76,-5.4,;28.12,-4.66,;28.13,-3.15,;29.48,-2.4,;29.48,-.89,;30.83,-.15,;30.84,1.36,;32.2,2.11,;29.51,2.12,;29.46,-5.43,;29.45,-6.93,;30.8,-4.67,;32.14,-5.44,;32.13,-6.95,;33.47,-7.71,;34.83,-6.96,;36.17,-7.72,;36.15,-9.24,;34.8,-9.99,;33.47,-9.22,;33.5,-4.69,;33.5,-3.19,;34.83,-5.46,;36.18,-4.72,;37.53,-5.48,;38.89,-4.73,;37.51,-6.99,)| Show InChI InChI=1S/C79H104N22O15/c1-4-5-20-56(96-77(116)67(44(2)3)101-68(107)54(80)33-46-25-28-52(102)29-26-46)69(108)91-42-65(104)93-62(37-51-40-86-43-92-51)75(114)98-60(35-47-24-27-48-17-9-10-18-49(48)32-47)73(112)94-58(23-14-31-88-79(84)85)72(111)99-61(36-50-39-89-55-21-12-11-19-53(50)55)74(113)100-63(38-66(105)106)76(115)95-57(22-13-30-87-78(82)83)71(110)97-59(70(109)90-41-64(81)103)34-45-15-7-6-8-16-45/h6-12,15-19,21,24-29,32,39-40,43-44,54,56-63,67,89,102H,4-5,13-14,20,22-23,30-31,33-38,41-42,80H2,1-3H3,(H2,81,103)(H,86,92)(H,90,109)(H,91,108)(H,93,104)(H,94,112)(H,95,115)(H,96,116)(H,97,110)(H,98,114)(H,99,111)(H,100,113)(H,101,107)(H,105,106)(H4,82,83,87)(H4,84,85,88)/t54-,56-,57-,58-,59-,60?,61-,62-,63-,67-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50250591
(CHEMBL4072387)Show SMILES CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)CN[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O |r| Show InChI InChI=1S/C77H111N21O18S/c1-43(2)65(66(79)106)97-75(115)62-20-13-30-98(62)76(116)55(18-10-11-28-78)90-63(103)39-86-67(107)59(34-47-36-84-52-17-9-8-16-51(47)52)95-69(109)53(19-12-29-83-77(80)81)91-71(111)57(32-45-14-6-5-7-15-45)93-70(110)56(35-49-37-82-42-87-49)85-38-48(23-26-64(104)105)89-68(108)54(27-31-117-4)92-74(114)61(41-100)96-72(112)58(33-46-21-24-50(102)25-22-46)94-73(113)60(40-99)88-44(3)101/h5-9,14-17,21-22,24-25,36-37,42-43,48,53-62,65,84-85,99-100,102H,10-13,18-20,23,26-35,38-41,78H2,1-4H3,(H2,79,106)(H,82,87)(H,86,107)(H,88,101)(H,89,108)(H,90,103)(H,91,111)(H,92,114)(H,93,110)(H,94,113)(H,95,109)(H,96,112)(H,97,115)(H,104,105)(H4,80,81,83)/t48-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,65-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50134946
(CHEMBL2370964 | H-Tyr-Val-Nle-Gly-His-D-Nal(2')-Ar...)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |wU:68.72,8.22,90.96,wD:82.88,32.33,42.44,101.107,12.13,57.61,4.3,(2.47,-9.76,;1.17,-9.01,;1.19,-7.5,;-.16,-6.75,;-.14,-5.24,;-1.49,-4.47,;-2.84,-5.23,;-2.85,-6.73,;-4.17,-4.45,;-5.53,-5.2,;-6.86,-4.44,;-6.86,-2.92,;-8.22,-5.18,;-9.55,-4.42,;-8.24,-6.7,;-6.9,-7.44,;-5.56,-6.71,;-4.2,-7.47,;-4.23,-8.99,;-2.87,-9.75,;-5.57,-9.73,;-6.91,-8.97,;-4.17,-2.95,;-5.5,-2.19,;-2.82,-2.2,;1.2,-4.49,;1.22,-2.98,;2.54,-5.26,;3.9,-4.5,;5.23,-5.27,;5.21,-6.79,;6.58,-4.52,;7.92,-5.29,;7.92,-6.79,;9.25,-7.55,;10.69,-6.96,;11.71,-8.09,;10.92,-9.39,;9.41,-9.05,;9.28,-4.55,;9.3,-3.03,;10.61,-5.31,;11.96,-4.56,;11.96,-3.02,;11.17,-1.68,;9.62,-1.68,;8.85,-.34,;9.62,1.02,;8.85,2.36,;9.61,3.72,;11.17,3.72,;11.95,2.36,;11.17,1.02,;11.95,-.32,;13.31,-5.32,;13.29,-6.82,;14.65,-4.56,;15.99,-5.32,;15.98,-6.85,;17.32,-7.61,;17.3,-9.11,;18.65,-9.89,;18.63,-11.4,;19.98,-12.15,;17.29,-12.13,;17.35,-4.59,;17.36,-3.08,;18.69,-5.35,;20.05,-4.61,;20.05,-3.09,;21.4,-2.35,;22.81,-2.98,;23.86,-1.85,;23.1,-.55,;23.58,.89,;22.56,2.03,;21.03,1.71,;20.53,.28,;21.57,-.85,;21.37,-5.37,;21.37,-6.88,;22.73,-4.62,;24.06,-5.4,;24.06,-6.9,;25.41,-7.67,;26.74,-6.9,;25.39,-9.17,;25.41,-4.64,;25.43,-3.14,;26.76,-5.4,;28.12,-4.66,;28.13,-3.15,;29.48,-2.4,;29.48,-.89,;30.83,-.15,;30.84,1.36,;32.2,2.11,;29.51,2.12,;29.46,-5.43,;29.45,-6.93,;30.8,-4.67,;32.14,-5.44,;32.13,-6.95,;33.47,-7.71,;34.83,-6.96,;36.17,-7.72,;36.15,-9.24,;34.8,-9.99,;33.47,-9.22,;33.5,-4.69,;33.5,-3.19,;34.83,-5.46,;36.18,-4.72,;37.53,-5.48,;38.89,-4.73,;37.51,-6.99,)| Show InChI InChI=1S/C79H104N22O15/c1-4-5-20-56(96-77(116)67(44(2)3)101-68(107)54(80)33-46-25-28-52(102)29-26-46)69(108)91-42-65(104)93-62(37-51-40-86-43-92-51)75(114)98-60(35-47-24-27-48-17-9-10-18-49(48)32-47)73(112)94-58(23-14-31-88-79(84)85)72(111)99-61(36-50-39-89-55-21-12-11-19-53(50)55)74(113)100-63(38-66(105)106)76(115)95-57(22-13-30-87-78(82)83)71(110)97-59(70(109)90-41-64(81)103)34-45-15-7-6-8-16-45/h6-12,15-19,21,24-29,32,39-40,43-44,54,56-63,67,89,102H,4-5,13-14,20,22-23,30-31,33-38,41-42,80H2,1-3H3,(H2,81,103)(H,86,92)(H,90,109)(H,91,108)(H,93,104)(H,94,112)(H,95,115)(H,96,116)(H,97,110)(H,98,114)(H,99,111)(H,100,113)(H,101,107)(H,105,106)(H4,82,83,87)(H4,84,85,88)/t54-,56-,57-,58-,59-,60?,61-,62-,63-,67-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50080875
(CHEMBL3421677)Show SMILES CC(=O)N[C@H]1Cc2c(CN([C@H](Cc3ccc(F)cc3)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(N)=O)C1=O)[nH]c1ccccc21 |r| | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Brussel
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC4 receptor expressed in HEK293 cells by gamma counting analysis |
ACS Med Chem Lett 6: 192-7 (2015)
Article DOI: 10.1021/ml500436s
BindingDB Entry DOI: 10.7270/Q24B330P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50250590
(CHEMBL4081900)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C72H100N16O15/c1-41(2)32-51(86-71(103)61(43(5)6)87-62(94)49(73)34-47-26-28-48(89)29-27-47)63(95)79-40-59(91)88-31-17-25-57(88)70(102)85-55(37-46-22-14-9-15-23-46)68(100)81-52(33-42(3)4)66(98)83-54(36-45-20-12-8-13-21-45)67(99)84-56(38-60(92)93)69(101)80-50(24-16-30-77-72(75)76)65(97)82-53(64(96)78-39-58(74)90)35-44-18-10-7-11-19-44/h7-15,18-23,26-29,41-43,49-57,61,89H,16-17,24-25,30-40,73H2,1-6H3,(H2,74,90)(H,78,96)(H,79,95)(H,80,101)(H,81,100)(H,82,97)(H,83,98)(H,84,99)(H,85,102)(H,86,103)(H,87,94)(H,92,93)(H4,75,76,77)/t49-,50-,51-,52-,53-,54-,55-,56-,57-,61-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50250589
(CHEMBL4060000)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C74H101N17O15/c1-41(2)31-53(89-73(106)63(43(5)6)90-64(97)50(75)33-46-25-27-48(92)28-26-46)65(98)82-40-61(94)91-30-16-24-59(91)72(105)88-56(35-45-19-11-8-12-20-45)69(102)84-54(32-42(3)4)68(101)86-57(36-47-38-80-51-22-14-13-21-49(47)51)70(103)87-58(37-62(95)96)71(104)83-52(23-15-29-79-74(77)78)67(100)85-55(66(99)81-39-60(76)93)34-44-17-9-7-10-18-44/h7-14,17-22,25-28,38,41-43,50,52-59,63,80,92H,15-16,23-24,29-37,39-40,75H2,1-6H3,(H2,76,93)(H,81,99)(H,82,98)(H,83,104)(H,84,102)(H,85,100)(H,86,101)(H,87,103)(H,88,105)(H,89,106)(H,90,97)(H,95,96)(H4,77,78,79)/t50-,52-,53-,54-,55-,56-,57-,58-,59-,63-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50250581
(CHEMBL4068475)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C75H101N19O15/c1-41(2)28-54(93-74(109)64(43(5)6)94-65(100)51(76)30-46-23-25-49(95)26-24-46)66(101)84-39-62(97)86-59(34-48-37-80-40-85-48)72(107)90-57(32-45-18-11-8-12-19-45)70(105)88-55(29-42(3)4)69(104)91-58(33-47-36-82-52-21-14-13-20-50(47)52)71(106)92-60(35-63(98)99)73(108)87-53(22-15-27-81-75(78)79)68(103)89-56(67(102)83-38-61(77)96)31-44-16-9-7-10-17-44/h7-14,16-21,23-26,36-37,40-43,51,53-60,64,82,95H,15,22,27-35,38-39,76H2,1-6H3,(H2,77,96)(H,80,85)(H,83,102)(H,84,101)(H,86,97)(H,87,108)(H,88,105)(H,89,103)(H,90,107)(H,91,104)(H,92,106)(H,93,109)(H,94,100)(H,98,99)(H4,78,79,81)/t51-,53-,54-,55-,56-,57-,58-,59-,60-,64-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50250587
(CHEMBL4079302)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C74H102N20O15/c1-41(2)32-53(92-72(109)62(42(3)4)93-63(100)49(75)33-45-25-27-47(95)28-26-45)64(101)85-40-60(97)94-31-15-24-58(94)71(108)91-55(35-44-18-9-6-10-19-44)68(105)86-52(23-14-30-82-74(79)80)67(104)89-56(36-46-38-83-50-21-12-11-20-48(46)50)69(106)90-57(37-61(98)99)70(107)87-51(22-13-29-81-73(77)78)66(103)88-54(65(102)84-39-59(76)96)34-43-16-7-5-8-17-43/h5-12,16-21,25-28,38,41-42,49,51-58,62,83,95H,13-15,22-24,29-37,39-40,75H2,1-4H3,(H2,76,96)(H,84,102)(H,85,101)(H,86,105)(H,87,107)(H,88,103)(H,89,104)(H,90,106)(H,91,108)(H,92,109)(H,93,100)(H,98,99)(H4,77,78,81)(H4,79,80,82)/t49-,51-,52-,53-,54-,55-,56-,57-,58-,62-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50250588
(CHEMBL4103570)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C72H101N19O15/c1-41(2)33-51(89-70(106)60(42(3)4)90-61(97)48(73)34-46-26-28-47(92)29-27-46)62(98)82-40-58(94)91-32-16-25-56(91)69(105)88-54(37-45-21-12-7-13-22-45)66(102)83-50(24-15-31-80-72(77)78)65(101)86-53(36-44-19-10-6-11-20-44)67(103)87-55(38-59(95)96)68(104)84-49(23-14-30-79-71(75)76)64(100)85-52(63(99)81-39-57(74)93)35-43-17-8-5-9-18-43/h5-13,17-22,26-29,41-42,48-56,60,92H,14-16,23-25,30-40,73H2,1-4H3,(H2,74,93)(H,81,99)(H,82,98)(H,83,102)(H,84,104)(H,85,100)(H,86,101)(H,87,103)(H,88,105)(H,89,106)(H,90,97)(H,95,96)(H4,75,76,79)(H4,77,78,80)/t48-,49-,50-,51-,52-,53-,54-,55-,56-,60-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50250591
(CHEMBL4072387)Show SMILES CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)CN[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O |r| Show InChI InChI=1S/C77H111N21O18S/c1-43(2)65(66(79)106)97-75(115)62-20-13-30-98(62)76(116)55(18-10-11-28-78)90-63(103)39-86-67(107)59(34-47-36-84-52-17-9-8-16-51(47)52)95-69(109)53(19-12-29-83-77(80)81)91-71(111)57(32-45-14-6-5-7-15-45)93-70(110)56(35-49-37-82-42-87-49)85-38-48(23-26-64(104)105)89-68(108)54(27-31-117-4)92-74(114)61(41-100)96-72(112)58(33-46-21-24-50(102)25-22-46)94-73(113)60(40-99)88-44(3)101/h5-9,14-17,21-22,24-25,36-37,42-43,48,53-62,65,84-85,99-100,102H,10-13,18-20,23,26-35,38-41,78H2,1-4H3,(H2,79,106)(H,82,87)(H,86,107)(H,88,101)(H,89,108)(H,90,103)(H,91,111)(H,92,114)(H,93,110)(H,94,113)(H,95,109)(H,96,112)(H,97,115)(H,104,105)(H4,80,81,83)/t48-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,65-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50250583
(CHEMBL4089770)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C75H101N21O16/c1-41(2)29-54(95-73(112)63(42(3)4)96-64(103)50(76)30-45-23-25-48(97)26-24-45)65(104)85-38-60(98)88-58(34-47-37-81-40-87-47)71(110)92-56(32-44-17-9-6-10-18-44)69(108)89-53(22-14-28-83-75(79)80)68(107)93-57(33-46-36-84-51-20-12-11-19-49(46)51)70(109)94-59(35-61(99)100)72(111)90-52(21-13-27-82-74(77)78)67(106)91-55(66(105)86-39-62(101)102)31-43-15-7-5-8-16-43/h5-12,15-20,23-26,36-37,40-42,50,52-59,63,84,97H,13-14,21-22,27-35,38-39,76H2,1-4H3,(H,81,87)(H,85,104)(H,86,105)(H,88,98)(H,89,108)(H,90,111)(H,91,106)(H,92,110)(H,93,107)(H,94,109)(H,95,112)(H,96,103)(H,99,100)(H,101,102)(H4,77,78,82)(H4,79,80,83)/t50-,52-,53-,54-,55-,56-,57-,58-,59-,63-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50250583
(CHEMBL4089770)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C75H101N21O16/c1-41(2)29-54(95-73(112)63(42(3)4)96-64(103)50(76)30-45-23-25-48(97)26-24-45)65(104)85-38-60(98)88-58(34-47-37-81-40-87-47)71(110)92-56(32-44-17-9-6-10-18-44)69(108)89-53(22-14-28-83-75(79)80)68(107)93-57(33-46-36-84-51-20-12-11-19-49(46)51)70(109)94-59(35-61(99)100)72(111)90-52(21-13-27-82-74(77)78)67(106)91-55(66(105)86-39-62(101)102)31-43-15-7-5-8-16-43/h5-12,15-20,23-26,36-37,40-42,50,52-59,63,84,97H,13-14,21-22,27-35,38-39,76H2,1-4H3,(H,81,87)(H,85,104)(H,86,105)(H,88,98)(H,89,108)(H,90,111)(H,91,106)(H,92,110)(H,93,107)(H,94,109)(H,95,112)(H,96,103)(H,99,100)(H,101,102)(H4,77,78,82)(H4,79,80,83)/t50-,52-,53-,54-,55-,56-,57-,58-,59-,63-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50250580
(CHEMBL4088516)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C73H100N18O15/c1-41(2)29-52(90-72(106)62(43(5)6)91-63(97)50(74)31-47-24-26-49(92)27-25-47)64(98)81-39-60(94)83-57(35-48-37-78-40-82-48)70(104)88-55(33-45-19-12-8-13-20-45)68(102)85-53(30-42(3)4)67(101)87-56(34-46-21-14-9-15-22-46)69(103)89-58(36-61(95)96)71(105)84-51(23-16-28-79-73(76)77)66(100)86-54(65(99)80-38-59(75)93)32-44-17-10-7-11-18-44/h7-15,17-22,24-27,37,40-43,50-58,62,92H,16,23,28-36,38-39,74H2,1-6H3,(H2,75,93)(H,78,82)(H,80,99)(H,81,98)(H,83,94)(H,84,105)(H,85,102)(H,86,100)(H,87,101)(H,88,104)(H,89,103)(H,90,106)(H,91,97)(H,95,96)(H4,76,77,79)/t50-,51-,52-,53-,54-,55-,56-,57-,58-,62-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50250591
(CHEMBL4072387)Show SMILES CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)CN[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O |r| Show InChI InChI=1S/C77H111N21O18S/c1-43(2)65(66(79)106)97-75(115)62-20-13-30-98(62)76(116)55(18-10-11-28-78)90-63(103)39-86-67(107)59(34-47-36-84-52-17-9-8-16-51(47)52)95-69(109)53(19-12-29-83-77(80)81)91-71(111)57(32-45-14-6-5-7-15-45)93-70(110)56(35-49-37-82-42-87-49)85-38-48(23-26-64(104)105)89-68(108)54(27-31-117-4)92-74(114)61(41-100)96-72(112)58(33-46-21-24-50(102)25-22-46)94-73(113)60(40-99)88-44(3)101/h5-9,14-17,21-22,24-25,36-37,42-43,48,53-62,65,84-85,99-100,102H,10-13,18-20,23,26-35,38-41,78H2,1-4H3,(H2,79,106)(H,82,87)(H,86,107)(H,88,101)(H,89,108)(H,90,103)(H,91,111)(H,92,114)(H,93,110)(H,94,113)(H,95,109)(H,96,112)(H,97,115)(H,104,105)(H4,80,81,83)/t48-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,65-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50250582
(CHEMBL4068654)Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C73H100N20O15S/c1-41(2)61(92-62(99)48(74)33-44-24-26-46(94)27-25-44)71(108)87-52(28-32-109-3)63(100)84-40-59(96)93-31-14-23-57(93)70(107)91-54(35-43-17-8-5-9-18-43)67(104)85-51(22-13-30-81-73(78)79)66(103)89-55(36-45-38-82-49-20-11-10-19-47(45)49)68(105)90-56(37-60(97)98)69(106)86-50(21-12-29-80-72(76)77)65(102)88-53(64(101)83-39-58(75)95)34-42-15-6-4-7-16-42/h4-11,15-20,24-27,38,41,48,50-57,61,82,94H,12-14,21-23,28-37,39-40,74H2,1-3H3,(H2,75,95)(H,83,101)(H,84,100)(H,85,104)(H,86,106)(H,87,108)(H,88,102)(H,89,103)(H,90,105)(H,91,107)(H,92,99)(H,97,98)(H4,76,77,80)(H4,78,79,81)/t48-,50-,51-,52-,53-,54-,55-,56-,57-,61-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50080877
(CHEMBL3421679)Show SMILES CC(=O)N[C@H]1Cc2ccccc2CN([C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O |r| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Brussel
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysis |
ACS Med Chem Lett 6: 192-7 (2015)
Article DOI: 10.1021/ml500436s
BindingDB Entry DOI: 10.7270/Q24B330P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50250585
(CHEMBL4104092)Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C74H100N22O15S/c1-41(2)62(96-63(102)49(75)30-44-22-24-47(97)25-23-44)72(111)91-53(26-29-112-3)64(103)86-39-60(99)88-57(34-46-37-81-40-87-46)70(109)93-55(32-43-16-8-5-9-17-43)68(107)89-52(21-13-28-83-74(79)80)67(106)94-56(33-45-36-84-50-19-11-10-18-48(45)50)69(108)95-58(35-61(100)101)71(110)90-51(20-12-27-82-73(77)78)66(105)92-54(65(104)85-38-59(76)98)31-42-14-6-4-7-15-42/h4-11,14-19,22-25,36-37,40-41,49,51-58,62,84,97H,12-13,20-21,26-35,38-39,75H2,1-3H3,(H2,76,98)(H,81,87)(H,85,104)(H,86,103)(H,88,99)(H,89,107)(H,90,110)(H,91,111)(H,92,105)(H,93,109)(H,94,106)(H,95,108)(H,96,102)(H,100,101)(H4,77,78,82)(H4,79,80,83)/t49-,51-,52-,53-,54-,55-,56-,57-,58-,62-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50250584
(CHEMBL4090684)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C75H102N22O15/c1-41(2)29-54(96-73(112)63(42(3)4)97-64(103)50(76)30-45-23-25-48(98)26-24-45)65(104)87-39-61(100)89-58(34-47-37-82-40-88-47)71(110)93-56(32-44-17-9-6-10-18-44)69(108)90-53(22-14-28-84-75(80)81)68(107)94-57(33-46-36-85-51-20-12-11-19-49(46)51)70(109)95-59(35-62(101)102)72(111)91-52(21-13-27-83-74(78)79)67(106)92-55(66(105)86-38-60(77)99)31-43-15-7-5-8-16-43/h5-12,15-20,23-26,36-37,40-42,50,52-59,63,85,98H,13-14,21-22,27-35,38-39,76H2,1-4H3,(H2,77,99)(H,82,88)(H,86,105)(H,87,104)(H,89,100)(H,90,108)(H,91,111)(H,92,106)(H,93,110)(H,94,107)(H,95,109)(H,96,112)(H,97,103)(H,101,102)(H4,78,79,83)(H4,80,81,84)/t50-,52-,53-,54-,55-,56-,57-,58-,59-,63-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
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PubMed
| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50250585
(CHEMBL4104092)Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C74H100N22O15S/c1-41(2)62(96-63(102)49(75)30-44-22-24-47(97)25-23-44)72(111)91-53(26-29-112-3)64(103)86-39-60(99)88-57(34-46-37-81-40-87-46)70(109)93-55(32-43-16-8-5-9-17-43)68(107)89-52(21-13-28-83-74(79)80)67(106)94-56(33-45-36-84-50-19-11-10-18-48(45)50)69(108)95-58(35-61(100)101)71(110)90-51(20-12-27-82-73(77)78)66(105)92-54(65(104)85-38-59(76)98)31-42-14-6-4-7-15-42/h4-11,14-19,22-25,36-37,40-41,49,51-58,62,84,97H,12-13,20-21,26-35,38-39,75H2,1-3H3,(H2,76,98)(H,81,87)(H,85,104)(H,86,103)(H,88,99)(H,89,107)(H,90,110)(H,91,111)(H,92,105)(H,93,109)(H,94,106)(H,95,108)(H,96,102)(H,100,101)(H4,77,78,82)(H4,79,80,83)/t49-,51-,52-,53-,54-,55-,56-,57-,58-,62-/m0/s1 | PDB
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UniProtKB/SwissProt
antibodypedia
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PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50250583
(CHEMBL4089770)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C75H101N21O16/c1-41(2)29-54(95-73(112)63(42(3)4)96-64(103)50(76)30-45-23-25-48(97)26-24-45)65(104)85-38-60(98)88-58(34-47-37-81-40-87-47)71(110)92-56(32-44-17-9-6-10-18-44)69(108)89-53(22-14-28-83-75(79)80)68(107)93-57(33-46-36-84-51-20-12-11-19-49(46)51)70(109)94-59(35-61(99)100)72(111)90-52(21-13-27-82-74(77)78)67(106)91-55(66(105)86-39-62(101)102)31-43-15-7-5-8-16-43/h5-12,15-20,23-26,36-37,40-42,50,52-59,63,84,97H,13-14,21-22,27-35,38-39,76H2,1-4H3,(H,81,87)(H,85,104)(H,86,105)(H,88,98)(H,89,108)(H,90,111)(H,91,106)(H,92,110)(H,93,107)(H,94,109)(H,95,112)(H,96,103)(H,99,100)(H,101,102)(H4,77,78,82)(H4,79,80,83)/t50-,52-,53-,54-,55-,56-,57-,58-,59-,63-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50250584
(CHEMBL4090684)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C75H102N22O15/c1-41(2)29-54(96-73(112)63(42(3)4)97-64(103)50(76)30-45-23-25-48(98)26-24-45)65(104)87-39-61(100)89-58(34-47-37-82-40-88-47)71(110)93-56(32-44-17-9-6-10-18-44)69(108)90-53(22-14-28-84-75(80)81)68(107)94-57(33-46-36-85-51-20-12-11-19-49(46)51)70(109)95-59(35-62(101)102)72(111)91-52(21-13-27-83-74(78)79)67(106)92-55(66(105)86-38-60(77)99)31-43-15-7-5-8-16-43/h5-12,15-20,23-26,36-37,40-42,50,52-59,63,85,98H,13-14,21-22,27-35,38-39,76H2,1-4H3,(H2,77,99)(H,82,88)(H,86,105)(H,87,104)(H,89,100)(H,90,108)(H,91,111)(H,92,106)(H,93,110)(H,94,107)(H,95,109)(H,96,112)(H,97,103)(H,101,102)(H4,78,79,83)(H4,80,81,84)/t50-,52-,53-,54-,55-,56-,57-,58-,59-,63-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
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Similars
| Article
PubMed
| n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50080876
(CHEMBL3421678)Show SMILES CC(=O)N[C@H]1Cc2c(CN([C@H](Cc3ccc(Br)cc3)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(N)=O)C1=O)[nH]c1ccccc21 |r| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Brussel
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysis |
ACS Med Chem Lett 6: 192-7 (2015)
Article DOI: 10.1021/ml500436s
BindingDB Entry DOI: 10.7270/Q24B330P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50026883
(CHEMBL437050)Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(O)=O Show InChI InChI=1S/C74H99N21O16S/c1-41(2)62(95-63(102)49(75)30-44-22-24-47(96)25-23-44)72(111)90-53(26-29-112-3)64(103)84-38-59(97)87-57(34-46-37-80-40-86-46)70(109)92-55(32-43-16-8-5-9-17-43)68(107)88-52(21-13-28-82-74(78)79)67(106)93-56(33-45-36-83-50-19-11-10-18-48(45)50)69(108)94-58(35-60(98)99)71(110)89-51(20-12-27-81-73(76)77)66(105)91-54(65(104)85-39-61(100)101)31-42-14-6-4-7-15-42/h4-11,14-19,22-25,36-37,40-41,49,51-58,62,83,96H,12-13,20-21,26-35,38-39,75H2,1-3H3,(H,80,86)(H,84,103)(H,85,104)(H,87,97)(H,88,107)(H,89,110)(H,90,111)(H,91,105)(H,92,109)(H,93,106)(H,94,108)(H,95,102)(H,98,99)(H,100,101)(H4,76,77,81)(H4,78,79,82)/t49-,51-,52-,53-,54-,55-,56-,57-,58-,62-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 71 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50250587
(CHEMBL4079302)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C74H102N20O15/c1-41(2)32-53(92-72(109)62(42(3)4)93-63(100)49(75)33-45-25-27-47(95)28-26-45)64(101)85-40-60(97)94-31-15-24-58(94)71(108)91-55(35-44-18-9-6-10-19-44)68(105)86-52(23-14-30-82-74(79)80)67(104)89-56(36-46-38-83-50-21-12-11-20-48(46)50)69(106)90-57(37-61(98)99)70(107)87-51(22-13-29-81-73(77)78)66(103)88-54(65(102)84-39-59(76)96)34-43-16-7-5-8-17-43/h5-12,16-21,25-28,38,41-42,49,51-58,62,83,95H,13-15,22-24,29-37,39-40,75H2,1-4H3,(H2,76,96)(H,84,102)(H,85,101)(H,86,105)(H,87,107)(H,88,103)(H,89,104)(H,90,106)(H,91,108)(H,92,109)(H,93,100)(H,98,99)(H4,77,78,81)(H4,79,80,82)/t49-,51-,52-,53-,54-,55-,56-,57-,58-,62-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50080876
(CHEMBL3421678)Show SMILES CC(=O)N[C@H]1Cc2c(CN([C@H](Cc3ccc(Br)cc3)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(N)=O)C1=O)[nH]c1ccccc21 |r| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Brussel
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells by gamma counting analysis |
ACS Med Chem Lett 6: 192-7 (2015)
Article DOI: 10.1021/ml500436s
BindingDB Entry DOI: 10.7270/Q24B330P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50250589
(CHEMBL4060000)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C74H101N17O15/c1-41(2)31-53(89-73(106)63(43(5)6)90-64(97)50(75)33-46-25-27-48(92)28-26-46)65(98)82-40-61(94)91-30-16-24-59(91)72(105)88-56(35-45-19-11-8-12-20-45)69(102)84-54(32-42(3)4)68(101)86-57(36-47-38-80-51-22-14-13-21-49(47)51)70(103)87-58(37-62(95)96)71(104)83-52(23-15-29-79-74(77)78)67(100)85-55(66(99)81-39-60(76)93)34-44-17-9-7-10-18-44/h7-14,17-22,25-28,38,41-43,50,52-59,63,80,92H,15-16,23-24,29-37,39-40,75H2,1-6H3,(H2,76,93)(H,81,99)(H,82,98)(H,83,104)(H,84,102)(H,85,100)(H,86,101)(H,87,103)(H,88,105)(H,89,106)(H,90,97)(H,95,96)(H4,77,78,79)/t50-,52-,53-,54-,55-,56-,57-,58-,59-,63-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 117 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50250582
(CHEMBL4068654)Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C73H100N20O15S/c1-41(2)61(92-62(99)48(74)33-44-24-26-46(94)27-25-44)71(108)87-52(28-32-109-3)63(100)84-40-59(96)93-31-14-23-57(93)70(107)91-54(35-43-17-8-5-9-18-43)67(104)85-51(22-13-30-81-73(78)79)66(103)89-55(36-45-38-82-49-20-11-10-19-47(45)49)68(105)90-56(37-60(97)98)69(106)86-50(21-12-29-80-72(76)77)65(102)88-53(64(101)83-39-58(75)95)34-42-15-6-4-7-16-42/h4-11,15-20,24-27,38,41,48,50-57,61,82,94H,12-14,21-23,28-37,39-40,74H2,1-3H3,(H2,75,95)(H,83,101)(H,84,100)(H,85,104)(H,86,106)(H,87,108)(H,88,102)(H,89,103)(H,90,105)(H,91,107)(H,92,99)(H,97,98)(H4,76,77,80)(H4,78,79,81)/t48-,50-,51-,52-,53-,54-,55-,56-,57-,61-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 118 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50250581
(CHEMBL4068475)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C75H101N19O15/c1-41(2)28-54(93-74(109)64(43(5)6)94-65(100)51(76)30-46-23-25-49(95)26-24-46)66(101)84-39-62(97)86-59(34-48-37-80-40-85-48)72(107)90-57(32-45-18-11-8-12-19-45)70(105)88-55(29-42(3)4)69(104)91-58(33-47-36-82-52-21-14-13-20-50(47)52)71(106)92-60(35-63(98)99)73(108)87-53(22-15-27-81-75(78)79)68(103)89-56(67(102)83-38-61(77)96)31-44-16-9-7-10-17-44/h7-14,16-21,23-26,36-37,40-43,51,53-60,64,82,95H,15,22,27-35,38-39,76H2,1-6H3,(H2,77,96)(H,80,85)(H,83,102)(H,84,101)(H,86,97)(H,87,108)(H,88,105)(H,89,103)(H,90,107)(H,91,104)(H,92,106)(H,93,109)(H,94,100)(H,98,99)(H4,78,79,81)/t51-,53-,54-,55-,56-,57-,58-,59-,60-,64-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 137 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by gamma counting method |
J Med Chem 60: 9320-9329 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01295
BindingDB Entry DOI: 10.7270/Q2XG9TJB |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50080878
(CHEMBL3421680)Show SMILES CC(=O)N[C@H]1Cn2nncc2CN([C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(N)=O)C1=O |r| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 137 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Brussel
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysis |
ACS Med Chem Lett 6: 192-7 (2015)
Article DOI: 10.1021/ml500436s
BindingDB Entry DOI: 10.7270/Q24B330P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50080875
(CHEMBL3421677)Show SMILES CC(=O)N[C@H]1Cc2c(CN([C@H](Cc3ccc(F)cc3)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(N)=O)C1=O)[nH]c1ccccc21 |r| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 167 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Brussel
Curated by ChEMBL
| Assay Description
Displacement of [125I]-NDP-alpha-MSH from human MC5 receptor expressed in HEK293 cells by gamma counting analysis |
ACS Med Chem Lett 6: 192-7 (2015)
Article DOI: 10.1021/ml500436s
BindingDB Entry DOI: 10.7270/Q24B330P |
More data for this
Ligand-Target Pair | |
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