Found 156 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Sigma non-opioid intracellular receptor 1
(Cavia porcellus (Guinea pig)) | BDBM50083351
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3 | PDB
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| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Messina
Curated by ChEMBL
| Assay Description Displacement of [3H]-(+)-pentazocine from guinea pig brain sigma1 receptor after 150 mins by scintillation counting analysis |
Bioorg Med Chem 22: 393-7 (2013)
Article DOI: 10.1016/j.bmc.2013.11.014 BindingDB Entry DOI: 10.7270/Q2M32X79 |
More data for this Ligand-Target Pair | |
C-8 sterol isomerase ERG2
(Saccharomyces cerevisiae) | BDBM50080017
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show SMILES C[C@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 |r| Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m1/s1 | KEGG
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| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Innsbruck
Curated by ChEMBL
| Assay Description Affinity for ERG2 of Sacchromyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine radioligand |
J Med Chem 48: 4754-64 (2005)
Article DOI: 10.1021/jm049073+ BindingDB Entry DOI: 10.7270/Q2639QHB |
More data for this Ligand-Target Pair | |
Sigma non-opioid intracellular receptor 1
(Cavia porcellus (Guinea pig)) | BDBM50007674
((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)Show SMILES C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m0/s1 | PDB
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| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Bari
Curated by ChEMBL
| Assay Description Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membrane without cerebellum |
J Med Chem 51: 7523-31 (2009)
Article DOI: 10.1021/jm800965b BindingDB Entry DOI: 10.7270/Q21837D3 |
More data for this Ligand-Target Pair | |
Sigma non-opioid intracellular receptor 1
(Homo sapiens (Human)) | BDBM50080017
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show SMILES C[C@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 |r| Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m1/s1 | PDB
UniProtKB/SwissProt
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| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Innsbruck
Curated by ChEMBL
| Assay Description Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligand |
J Med Chem 48: 4754-64 (2005)
Article DOI: 10.1021/jm049073+ BindingDB Entry DOI: 10.7270/Q2639QHB |
More data for this Ligand-Target Pair | |
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
(Cavia porcellus) | BDBM50007674
((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)Show SMILES C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m0/s1 | UniProtKB/SwissProt
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| 2.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Bari
Curated by ChEMBL
| Assay Description Inhibition of [3H]-emopamil binding to Sterol delta 8-delta 7 isomerase in guinea pig liver membrane |
J Med Chem 46: 2117-24 (2003)
Article DOI: 10.1021/jm021014d BindingDB Entry DOI: 10.7270/Q2DF6RZR |
More data for this Ligand-Target Pair | |
Sigma intracellular receptor 2
(Rattus norvegicus (Rat)) | BDBM50007674
((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)Show SMILES C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m0/s1 | UniProtKB/SwissProt
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| 4.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of [3H](+)-[3H]di-o-tolylguanidine from sigma2 receptor in rat liver membranes |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01912 BindingDB Entry DOI: 10.7270/Q24T6P14 |
More data for this Ligand-Target Pair | |
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
(Cavia porcellus) | BDBM50007674
((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)Show SMILES C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m0/s1 | UniProtKB/SwissProt
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| 4.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Bari
Curated by ChEMBL
| Assay Description Displacement of [3H](+/-)-emopamil from delta8-delta7 sterol isomerase (SI) site in guinea pig liver membranes |
J Med Chem 48: 8237-44 (2005)
Article DOI: 10.1021/jm050654o BindingDB Entry DOI: 10.7270/Q2MP542J |
More data for this Ligand-Target Pair | |
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
(Homo sapiens (Human)) | BDBM50080017
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show SMILES C[C@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 |r| Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m1/s1 | PDB
Reactome pathway KEGG
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| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Innsbruck
Curated by ChEMBL
| Assay Description Affinity for human EMP expressed in ERG2 deficient strain of Sacchromyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine as radioligand |
J Med Chem 48: 4754-64 (2005)
Article DOI: 10.1021/jm049073+ BindingDB Entry DOI: 10.7270/Q2639QHB |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Homo sapiens (Human)) | BDBM50557186
(CHEMBL493054)Show SMILES C[C@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 |r| | PDB MMDB
NCI pathway Reactome pathway KEGG
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| 5.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of [3H]-unlike-ifenprodil from recombinant human GluN2B expressed in L-M(TK-) cell membranes by competitive receptor binding assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01912 BindingDB Entry DOI: 10.7270/Q24T6P14 |
More data for this Ligand-Target Pair | |
Sigma intracellular receptor 2
(Rattus norvegicus (Rat)) | BDBM50557186
(CHEMBL493054)Show SMILES C[C@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 |r| | UniProtKB/SwissProt
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| 6.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114359 BindingDB Entry DOI: 10.7270/Q25M69QS |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Homo sapiens (Human)) | BDBM50080017
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show SMILES C[C@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 |r| Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
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| 7.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of [3H]-unlike-ifenprodil from recombinant human GluN2B expressed in L-M(TK-) cell membranes by competitive receptor binding assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01912 BindingDB Entry DOI: 10.7270/Q24T6P14 |
More data for this Ligand-Target Pair | |
Sigma intracellular receptor 2
(Rattus norvegicus (Rat)) | BDBM50007677
((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)Show SMILES C[C@@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21+/m0/s1 | UniProtKB/SwissProt
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| 8.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of [3H](+)-[3H]di-o-tolylguanidine from sigma2 receptor in rat liver membranes |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01912 BindingDB Entry DOI: 10.7270/Q24T6P14 |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Homo sapiens (Human)) | BDBM50083351
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
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| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Westf£lische Wilhelms-Universit£t M£nster
Curated by ChEMBL
| Assay Description Displacement of [3H]ifenprodil from human recombinant GluN2B expressed in mouse L(tk-) cell membranes co-expressing GluN1a incubated for 120 mins by ... |
Bioorg Med Chem 28: (2020)
Article DOI: 10.1016/j.bmc.2019.115245 BindingDB Entry DOI: 10.7270/Q2N01B2X |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 2B
(Homo sapiens (Human)) | BDBM50083351
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
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| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Trieste
Curated by ChEMBL
| Assay Description Displacement of [3H]ifenprodil from GluN2B (unknown origin) expressed in mouse L(tk-) cell membranes co-expressing GluN1a incubated for 120 mins by s... |
ACS Med Chem Lett 11: 651-656 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00524 BindingDB Entry DOI: 10.7270/Q2ZS3134 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 2B
(Homo sapiens (Human)) | BDBM50080017
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show SMILES C[C@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 |r| Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
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| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster
Curated by ChEMBL
| Assay Description Displacement of [3H]ifenprodil from human GluN2B expressed in mouse L(tk-) cell membranes co-expressing GluN1a incubated for 120 mins by scintillatio... |
Bioorg Med Chem 27: 3559-3567 (2019)
Article DOI: 10.1016/j.bmc.2019.06.035 BindingDB Entry DOI: 10.7270/Q2HX1H05 |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Homo sapiens (Human)) | BDBM50007677
((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)Show SMILES C[C@@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
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| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Munster
Curated by ChEMBL
| Assay Description Displacement of [3H]ifenprodil from Glun2B receptor (unknown origin) expressed in mouse L(tk-) cell membranes after 120 mins by scintillation countin... |
Bioorg Med Chem Lett 25: 5748-51 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.076 BindingDB Entry DOI: 10.7270/Q2639SQV |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 1/2B
(Homo sapiens (Human)) | BDBM50007677
((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)Show SMILES C[C@@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
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| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut für Pharmazeutische und Medizinische Chemie der Universität Münster, Corrensstra?e 48, D-48149 Münster, Germany.
Curated by ChEMBL
| Assay Description Displacement of [3H]ifenprodil from human NR1-1a/NR2B receptor expressed in Mouse L(tk-) cell membranes incubated for 120 mins by scintillation count... |
Bioorg Med Chem 25: 5365-5372 (2017)
Article DOI: 10.1016/j.bmc.2017.07.059 BindingDB Entry DOI: 10.7270/Q25M6856 |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 1/2B
(Homo sapiens (Human)) | BDBM50083351
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
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| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut f£r Pharmazeutische und Medizinische Chemie der Westf£lischen Wilhelms-Universit£t M£nster
Curated by ChEMBL
| Assay Description Displacement of [3H]-ifenprodil from GluN1a/GluN2B (unknown origin) expressed in L(tk-) cell membranes after 120 mins by scintillation counting analy... |
Eur J Med Chem 157: 397-404 (2018)
Article DOI: 10.1016/j.ejmech.2018.08.003 BindingDB Entry DOI: 10.7270/Q2XG9TTX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 2B
(Homo sapiens (Human)) | BDBM50083351
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
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| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster
Curated by ChEMBL
| Assay Description Displacement of [3H]Ifenprodil from GluN2B receptor (unknown origin) expressed in mouse L(tk-) cell membranes incubated for 120 mins measured for 5 m... |
Eur J Med Chem 144: 672-681 (2018)
Article DOI: 10.1016/j.ejmech.2017.12.054 BindingDB Entry DOI: 10.7270/Q2B56NDZ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
(Cavia porcellus) | BDBM50007674
((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)Show SMILES C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m0/s1 | UniProtKB/SwissProt
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| Article PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Bari
Curated by ChEMBL
| Assay Description Displacement of [3H](+/-)-emopamil from EBP in Dunkin guinea pig liver membrane by radioreceptor binding assay |
J Med Chem 52: 7817-28 (2009)
Article DOI: 10.1021/jm9007505 BindingDB Entry DOI: 10.7270/Q2CJ8FDB |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Homo sapiens (Human)) | BDBM50007677
((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)Show SMILES C[C@@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
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| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster
Curated by ChEMBL
| Assay Description Displacement of [3H]ifenprodil from recombinant human GluN2B expressed in mouse L(tk-) cell membranes incubated for 120 mins by microbeta scintillati... |
Eur J Med Chem 116: 136-146 (2016)
Article DOI: 10.1016/j.ejmech.2016.03.065 BindingDB Entry DOI: 10.7270/Q261126Q |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Homo sapiens (Human)) | BDBM50083351
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3 | PDB MMDB
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| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster
Curated by ChEMBL
| Assay Description Displacement of [3H]ifenprodil from human GluN2B expressed in mouse L(tk-) cells co-expressing GluN1a after 120 mins by scintillation counting method |
Bioorg Med Chem 22: 6638-46 (2015)
Article DOI: 10.1016/j.bmc.2014.10.004 BindingDB Entry DOI: 10.7270/Q2ZW1NH7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 2B
(Homo sapiens (Human)) | BDBM50083351
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3 | PDB MMDB
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| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01003 BindingDB Entry DOI: 10.7270/Q2J38XKF |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 2B
(Homo sapiens (Human)) | BDBM50083351
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3 | PDB MMDB
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| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of [3H]ifenprodil from human GluN2B expressed in mouse L(tk-) cell membranes co-expressing GluN1a incubated for 2 hrs by scintillation c... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112138 BindingDB Entry DOI: 10.7270/Q2D50RKS |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat)) | BDBM50007674
((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)Show SMILES C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m0/s1 | PDB
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| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Louis Pasteur de Strasbourg
Curated by ChEMBL
| Assay Description Displacement of [3H]ifenprodil from rat brain membrane NR2B receptor |
Bioorg Med Chem Lett 18: 2765-70 (2008)
Article DOI: 10.1016/j.bmcl.2008.04.019 BindingDB Entry DOI: 10.7270/Q21C1XR4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50007674
((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)Show SMILES C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m0/s1 | PDB
Reactome pathway KEGG
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| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Binding affinity towards Alpha-1 adrenergic receptor in rat brain using [3H]prazosin |
Bioorg Med Chem Lett 13: 1759-62 (2003)
BindingDB Entry DOI: 10.7270/Q2513XKF |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Homo sapiens (Human)) | BDBM50007677
((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)Show SMILES C[C@@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21+/m0/s1 | PDB MMDB
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| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of [3H]-unlike-ifenprodil from recombinant human GluN2B expressed in L-M(TK-) cell membranes by competitive receptor binding assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01912 BindingDB Entry DOI: 10.7270/Q24T6P14 |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Homo sapiens (Human)) | BDBM50007674
((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)Show SMILES C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m0/s1 | PDB MMDB
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| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of [3H]-unlike-ifenprodil from recombinant human GluN2B expressed in L-M(TK-) cell membranes by competitive receptor binding assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01912 BindingDB Entry DOI: 10.7270/Q24T6P14 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
(Cavia porcellus) | BDBM50007674
((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)Show SMILES C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m0/s1 | UniProtKB/SwissProt
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| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari
Curated by ChEMBL
| Assay Description Displacement of [3H]-emopamil from delta(8)-delta(7) sterol isomerase in guinea pig liver membranes |
Bioorg Med Chem 19: 7612-22 (2011)
Article DOI: 10.1016/j.bmc.2011.10.023 BindingDB Entry DOI: 10.7270/Q2RX9CHF |
More data for this Ligand-Target Pair | |
Sigma intracellular receptor 2
(Rattus norvegicus (Rat)) | BDBM50080017
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show SMILES C[C@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 |r| Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m1/s1 | UniProtKB/SwissProt
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| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of [3H](+)-[3H]di-o-tolylguanidine from sigma2 receptor in rat liver membranes |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01912 BindingDB Entry DOI: 10.7270/Q24T6P14 |
More data for this Ligand-Target Pair | |
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
(Cavia porcellus) | BDBM50007674
((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)Show SMILES C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m0/s1 | UniProtKB/SwissProt
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| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Bari
Curated by ChEMBL
| Assay Description Displacement of [3H](-)-(S)-emopamil from EBP in guinea pig liver membrane |
J Med Chem 51: 7523-31 (2009)
Article DOI: 10.1021/jm800965b BindingDB Entry DOI: 10.7270/Q21837D3 |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat)) | BDBM50083351
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3 | PDB
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| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Messina
Curated by ChEMBL
| Assay Description Displacement of [3H]ifenprodil from Wistar rat cerebral cortex glutamate NMDA receptor GluN2B subunit after 120 mins by scintillation counting analys... |
Bioorg Med Chem 22: 393-7 (2013)
Article DOI: 10.1016/j.bmc.2013.11.014 BindingDB Entry DOI: 10.7270/Q2M32X79 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
(Cavia porcellus) | BDBM50007674
((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)Show SMILES C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m0/s1 | UniProtKB/SwissProt
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| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Bari
Curated by ChEMBL
| Assay Description Displacement of [3H]emopamil from Delta-(8)-Delta-(7) sterol isomerase in guinea pig liver membrane |
J Med Chem 50: 4648-55 (2007)
Article DOI: 10.1021/jm070373b BindingDB Entry DOI: 10.7270/Q2SQ917Z |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat)) | BDBM50007674
((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)Show SMILES C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m0/s1 | PDB
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| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hamamatsu University School of Medicine
Curated by ChEMBL
| Assay Description Displacement of [3H]ifenprodil from NR2B receptor in rat cortical synaptic membranes |
Bioorg Med Chem 18: 7497-506 (2010)
Article DOI: 10.1016/j.bmc.2010.08.053 BindingDB Entry DOI: 10.7270/Q2MS3T06 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 1
(RAT) | BDBM50007674
((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)Show SMILES C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m0/s1 | PDB
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| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by PDSP Ki Database
| |
J Neurochem 70: 2147-55 (1998)
Article DOI: 10.1046/j.1471-4159.1998.70052147.x BindingDB Entry DOI: 10.7270/Q2KP80Q7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sigma non-opioid intracellular receptor 1
(Cavia porcellus (Guinea pig)) | BDBM50007674
((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)Show SMILES C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m0/s1 | PDB
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| 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain membranes |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01912 BindingDB Entry DOI: 10.7270/Q24T6P14 |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50080017
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show SMILES C[C@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 |r| Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m1/s1 | PDB
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| 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of [3H]prazosin from alpha-1A adrenergic receptor (unknown origin) |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01912 BindingDB Entry DOI: 10.7270/Q24T6P14 |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat)) | BDBM50007674
((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)Show SMILES C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m0/s1 | PDB
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| 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto Italiano di Tecnologia
Curated by ChEMBL
| Assay Description Displacement of [3H]Ifenprodil from NMDAR-2B in Sprague-Dawley rat frontal cortex homogenates after 2 hrs by liquid scintillation counting |
J Med Chem 55: 9708-21 (2012)
Article DOI: 10.1021/jm3009458 BindingDB Entry DOI: 10.7270/Q2VQ33TR |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50080017
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show SMILES C[C@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 |r| Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m1/s1 | PDB
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| 46 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of [3H]-8-OH-DPAT from human 5-HT1A receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01912 BindingDB Entry DOI: 10.7270/Q24T6P14 |
More data for this Ligand-Target Pair | |
Sigma intracellular receptor 2
(Rattus norvegicus (Rat)) | BDBM50557186
(CHEMBL493054)Show SMILES C[C@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 |r| | UniProtKB/SwissProt
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| 63 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of [3H](+)-[3H]di-o-tolylguanidine from sigma2 receptor in rat liver membranes |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01912 BindingDB Entry DOI: 10.7270/Q24T6P14 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2B
(Homo sapiens (Human)) | BDBM50080017
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show SMILES C[C@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 |r| Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m1/s1 | PDB
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| 66 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01912 BindingDB Entry DOI: 10.7270/Q24T6P14 |
More data for this Ligand-Target Pair | |
Sigma non-opioid intracellular receptor 1
(Cavia porcellus (Guinea pig)) | BDBM50080017
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show SMILES C[C@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 |r| Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m1/s1 | PDB
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| 75 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain membranes |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01912 BindingDB Entry DOI: 10.7270/Q24T6P14 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2B
(Homo sapiens (Human)) | BDBM50007674
((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)Show SMILES C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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| 95 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01912 BindingDB Entry DOI: 10.7270/Q24T6P14 |
More data for this Ligand-Target Pair | |
Sigma non-opioid intracellular receptor 1
(Cavia porcellus (Guinea pig)) | BDBM50557186
(CHEMBL493054)Show SMILES C[C@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 |r| | PDB
UniProtKB/SwissProt
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| Article PubMed
| 96 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain membranes |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01912 BindingDB Entry DOI: 10.7270/Q24T6P14 |
More data for this Ligand-Target Pair | |
Sigma non-opioid intracellular receptor 1
(Cavia porcellus (Guinea pig)) | BDBM50557186
(CHEMBL493054)Show SMILES C[C@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 |r| | PDB
UniProtKB/SwissProt
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| 96 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114359 BindingDB Entry DOI: 10.7270/Q25M69QS |
More data for this Ligand-Target Pair | |
Sigma intracellular receptor 2
(Rattus norvegicus (Rat)) | BDBM50083351
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3 | UniProtKB/SwissProt
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| 98 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of [3H]DTG from sigma 2 receptor in rat liver membranes incubated for 120 mins by scintillation counting method |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112138 BindingDB Entry DOI: 10.7270/Q2D50RKS |
More data for this Ligand-Target Pair | |
Sigma intracellular receptor 2
(Rattus norvegicus (Rat)) | BDBM50083351
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3 | UniProtKB/SwissProt
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| 98 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut f£r Pharmazeutische und Medizinische Chemie der Westf£lischen Wilhelms-Universit£t M£nster
Curated by ChEMBL
| Assay Description Displacement of [3H]-di-o-tolylguanidine from sigma2 receptor in rat liver membranes incubated for 120 mins by scintillation counting method |
Eur J Med Chem 157: 397-404 (2018)
Article DOI: 10.1016/j.ejmech.2018.08.003 BindingDB Entry DOI: 10.7270/Q2XG9TTX |
More data for this Ligand-Target Pair | |
Sigma intracellular receptor 2
(Rattus norvegicus (Rat)) | BDBM50083351
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3 | UniProtKB/SwissProt
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| 98 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster
Curated by ChEMBL
| Assay Description Displacement of [3H]-di-o-tolylguanidine from sigma-2 receptor in rat liver membranes incubated for 120 mins measured for 5 mins by scintillation cou... |
Eur J Med Chem 144: 672-681 (2018)
Article DOI: 10.1016/j.ejmech.2017.12.054 BindingDB Entry DOI: 10.7270/Q2B56NDZ |
More data for this Ligand-Target Pair | |
Sigma intracellular receptor 2
(Rattus norvegicus (Rat)) | BDBM50083351
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3 | UniProtKB/SwissProt
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| 98 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut f£r Pharmazeutische und Medizinische Chemie der Westf£lischen Wilhelms-Universit£t M£nster
Curated by ChEMBL
| Assay Description Displacement of [3H]-DTG from sigma 2 receptor in rat liver membranes after 120 mins by scintillation counting analysis |
Bioorg Med Chem 26: 501-508 (2018)
Article DOI: 10.1016/j.bmc.2017.12.010 BindingDB Entry DOI: 10.7270/Q2MG7S3J |
More data for this Ligand-Target Pair | |
Sigma intracellular receptor 2
(Rattus norvegicus (Rat)) | BDBM50083351
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3 | UniProtKB/SwissProt
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| 98 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut f£r Pharmazeutische und Medizinische Chemie der Westf£lischen Wilhelms-Universit£t M£nster
Curated by ChEMBL
| Assay Description Displacement of [3H]DTG from sigma2 receptor in rat liver membranes after 120 mins by microbeta scintillation counting method |
Eur J Med Chem 138: 552-564 (2017)
Article DOI: 10.1016/j.ejmech.2017.06.068 BindingDB Entry DOI: 10.7270/Q2DV1NGG |
More data for this Ligand-Target Pair | |