Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AMP deaminase 1 (Oryctolagus cuniculus) | BDBM50004699 (CHEBI:45262 | CHEMBL96862 | US11185100, TABLE 9.3) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Similars | PubMed | 6.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AgrEvo UK Limited Curated by ChEMBL | Assay Description Inhibition of Oryctolagus cuniculus (rabbit) muscle adenylate deaminase | Bioorg Med Chem Lett 9: 1985-90 (1999) BindingDB Entry DOI: 10.7270/Q2WQ0591 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AMP deaminase 1 (Homo sapiens (Human)) | BDBM50087313 (8-(8-Hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]dia...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics Inc. Curated by ChEMBL | Assay Description Evaluated for the inhibition of porcine heart or human L-type Adenosine 5'-monophosphate deaminase (AMPDA) | J Med Chem 43: 1495-507 (2000) BindingDB Entry DOI: 10.7270/Q2Z31XWJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AMP deaminase 1 (Homo sapiens (Human)) | BDBM50087307 (3-Heptyl-3,6,7,8-tetrahydro-imidazo[4,5-d][1,3]dia...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics Inc. Curated by ChEMBL | Assay Description Evaluated for the inhibition of porcine heart or human L-type Adenosine 5'-monophosphate deaminase (AMPDA) | J Med Chem 43: 1495-507 (2000) BindingDB Entry DOI: 10.7270/Q2Z31XWJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AMP deaminase 1 (Homo sapiens (Human)) | BDBM50087317 (3-Octyl-3,6,7,8-tetrahydro-imidazo[4,5-d][1,3]diaz...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics Inc. Curated by ChEMBL | Assay Description Evaluated for the inhibition of porcine heart or human L-type Adenosine 5'-monophosphate deaminase (AMPDA) | J Med Chem 43: 1495-507 (2000) BindingDB Entry DOI: 10.7270/Q2Z31XWJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AMP deaminase 1 (Homo sapiens (Human)) | BDBM50087311 (8-(8-Hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]dia...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics Inc. Curated by ChEMBL | Assay Description Evaluated for the inhibition of porcine heart or human L-type Adenosine 5'-monophosphate deaminase (AMPDA) | J Med Chem 43: 1495-507 (2000) BindingDB Entry DOI: 10.7270/Q2Z31XWJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AMP deaminase 1 (Homo sapiens (Human)) | BDBM50087301 (CHEMBL290418 | Sodium; 4-(8-hydroxy-7,8-dihydro-6H...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 8.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics Inc. Curated by ChEMBL | Assay Description Evaluated for the inhibition of porcine heart or human L-type Adenosine 5'-monophosphate deaminase (AMPDA) | J Med Chem 43: 1495-507 (2000) BindingDB Entry DOI: 10.7270/Q2Z31XWJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AMP deaminase 1 (Homo sapiens (Human)) | BDBM50087303 (7-(8-Hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]dia...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.70E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics Inc. Curated by ChEMBL | Assay Description Evaluated for the inhibition of porcine heart or human L-type Adenosine 5'-monophosphate deaminase (AMPDA) | J Med Chem 43: 1495-507 (2000) BindingDB Entry DOI: 10.7270/Q2Z31XWJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AMP deaminase 1 (Rattus norvegicus (Rat)) | BDBM154584 (4-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | 7.4 | n/a |
AstraZeneca R&D | Assay Description AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis... | Chem Biol 21: 1486-96 (2014) Article DOI: 10.1016/j.chembiol.2014.09.011 BindingDB Entry DOI: 10.7270/Q2M0445M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AMP deaminase 1 (Mus musculus (Mouse)) | BDBM154584 (4-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | 7.4 | n/a |
AstraZeneca R&D | Assay Description AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis... | Chem Biol 21: 1486-96 (2014) Article DOI: 10.1016/j.chembiol.2014.09.011 BindingDB Entry DOI: 10.7270/Q2M0445M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AMP deaminase 1 (Mus musculus (Mouse)) | BDBM154583 (6-[4-({[(1S)-1-(isoquinolin-8-yl)ethyl]amino}methy...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 24 | n/a | n/a | n/a | n/a | 7.4 | n/a |
AstraZeneca R&D | Assay Description AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis... | Chem Biol 21: 1486-96 (2014) Article DOI: 10.1016/j.chembiol.2014.09.011 BindingDB Entry DOI: 10.7270/Q2M0445M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AMP deaminase 1 (Homo sapiens (Human)) | BDBM154584 (4-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 24 | n/a | n/a | n/a | n/a | 7.4 | n/a |
AstraZeneca R&D | Assay Description AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis... | Chem Biol 21: 1486-96 (2014) Article DOI: 10.1016/j.chembiol.2014.09.011 BindingDB Entry DOI: 10.7270/Q2M0445M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AMP deaminase 1 (Rattus norvegicus (Rat)) | BDBM154583 (6-[4-({[(1S)-1-(isoquinolin-8-yl)ethyl]amino}methy...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 27 | n/a | n/a | n/a | n/a | 7.4 | n/a |
AstraZeneca R&D | Assay Description AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis... | Chem Biol 21: 1486-96 (2014) Article DOI: 10.1016/j.chembiol.2014.09.011 BindingDB Entry DOI: 10.7270/Q2M0445M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AMP deaminase 1 (Homo sapiens (Human)) | BDBM154583 (6-[4-({[(1S)-1-(isoquinolin-8-yl)ethyl]amino}methy...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 38 | n/a | n/a | n/a | n/a | 7.4 | n/a |
AstraZeneca R&D | Assay Description AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis... | Chem Biol 21: 1486-96 (2014) Article DOI: 10.1016/j.chembiol.2014.09.011 BindingDB Entry DOI: 10.7270/Q2M0445M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AMP deaminase 1 (Oryctolagus cuniculus) | BDBM50004698 (CHEMBL1160282) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
AgrEvo UK Limited Curated by ChEMBL | Assay Description Inhibition of Oryctolagus cuniculus (rabbit) muscle adenylate deaminase | Bioorg Med Chem Lett 9: 1985-90 (1999) BindingDB Entry DOI: 10.7270/Q2WQ0591 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AMP deaminase 1 (Homo sapiens (Human)) | BDBM50096172 (1-Bromo-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of human skeletal muscle AMPD1 | ACS Med Chem Lett 1: 286-289 (2010) Article DOI: 10.1021/ml100092a BindingDB Entry DOI: 10.7270/Q2X0683X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AMP deaminase 1 (Homo sapiens (Human)) | BDBM154581 (6-[4-({[(1R)-1-(naphthalen-1-yl)ethyl]amino}methyl...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 620 | n/a | n/a | n/a | n/a | 7.4 | n/a |
AstraZeneca R&D | Assay Description AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis... | Chem Biol 21: 1486-96 (2014) Article DOI: 10.1016/j.chembiol.2014.09.011 BindingDB Entry DOI: 10.7270/Q2M0445M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AMP deaminase 1 (Mus musculus (Mouse)) | BDBM154582 (6-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
AstraZeneca R&D | Assay Description AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis... | Chem Biol 21: 1486-96 (2014) Article DOI: 10.1016/j.chembiol.2014.09.011 BindingDB Entry DOI: 10.7270/Q2M0445M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AMP deaminase 1 (Rattus norvegicus (Rat)) | BDBM154582 (6-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.80E+3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
AstraZeneca R&D | Assay Description AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis... | Chem Biol 21: 1486-96 (2014) Article DOI: 10.1016/j.chembiol.2014.09.011 BindingDB Entry DOI: 10.7270/Q2M0445M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AMP deaminase 1 (Homo sapiens (Human)) | BDBM154582 (6-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.20E+3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
AstraZeneca R&D | Assay Description AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis... | Chem Biol 21: 1486-96 (2014) Article DOI: 10.1016/j.chembiol.2014.09.011 BindingDB Entry DOI: 10.7270/Q2M0445M | |||||||||||
More data for this Ligand-Target Pair |