Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human)) | BDBM287595 (N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | 25 |
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.; Yangtze River Pharmaceutical Group Co., Ltd. US Patent | Assay Description All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas... | US Patent US10085983 (2018) BindingDB Entry DOI: 10.7270/Q28W3GBG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human)) | BDBM287615 (N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | 25 |
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.; Yangtze River Pharmaceutical Group Co., Ltd. US Patent | Assay Description All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas... | US Patent US10085983 (2018) BindingDB Entry DOI: 10.7270/Q28W3GBG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human)) | BDBM287608 (N-(2-(2-(dimethylamino)ethoxyl)-4-methoxy-5-(7-(1-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | 25 |
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.; Yangtze River Pharmaceutical Group Co., Ltd. US Patent | Assay Description All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas... | US Patent US10085983 (2018) BindingDB Entry DOI: 10.7270/Q28W3GBG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human)) | BDBM238274 (US9409887, I-5) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Celgene Avilomics Research, Inc. US Patent | Assay Description Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS... | US Patent US9409887 (2016) BindingDB Entry DOI: 10.7270/Q2028QDD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human)) | BDBM238271 (US9409887, I-2) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Celgene Avilomics Research, Inc. US Patent | Assay Description Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS... | US Patent US9409887 (2016) BindingDB Entry DOI: 10.7270/Q2028QDD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human)) | BDBM238270 (US9409887, I-1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Celgene Avilomics Research, Inc. US Patent | Assay Description Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS... | US Patent US9409887 (2016) BindingDB Entry DOI: 10.7270/Q2028QDD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human)) | BDBM287617 (US10085983, Compound J-12) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | 25 |
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.; Yangtze River Pharmaceutical Group Co., Ltd. US Patent | Assay Description All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas... | US Patent US10085983 (2018) BindingDB Entry DOI: 10.7270/Q28W3GBG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human)) | BDBM287609 ( N-(4-methoxy-5-(7-(1-methyl-1H-pyrazol-4-yl)pyrro...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | 25 |
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.; Yangtze River Pharmaceutical Group Co., Ltd. US Patent | Assay Description All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas... | US Patent US10085983 (2018) BindingDB Entry DOI: 10.7270/Q28W3GBG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human)) | BDBM287613 (N-(5(7-cyclopropylpyrrolo[1,2-f][1,2,4]triazin-2-y...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | 25 |
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.; Yangtze River Pharmaceutical Group Co., Ltd. US Patent | Assay Description All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas... | US Patent US10085983 (2018) BindingDB Entry DOI: 10.7270/Q28W3GBG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human)) | BDBM287607 (N-(2-(4-(dimethylamino)piperidin-1-yl)-4-methoxy-5...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | 25 |
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.; Yangtze River Pharmaceutical Group Co., Ltd. US Patent | Assay Description All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas... | US Patent US10085983 (2018) BindingDB Entry DOI: 10.7270/Q28W3GBG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human)) | BDBM287612 (N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | 25 |
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.; Yangtze River Pharmaceutical Group Co., Ltd. US Patent | Assay Description All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas... | US Patent US10085983 (2018) BindingDB Entry DOI: 10.7270/Q28W3GBG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human)) | BDBM50029668 (AZD-9291 | Osimertinib | US10085983, Compound AZD-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | PDB US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | 25 |
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.; Yangtze River Pharmaceutical Group Co., Ltd. US Patent | Assay Description All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas... | US Patent US10085983 (2018) BindingDB Entry DOI: 10.7270/Q28W3GBG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human)) | BDBM287611 (N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | 25 |
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.; Yangtze River Pharmaceutical Group Co., Ltd. US Patent | Assay Description All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas... | US Patent US10085983 (2018) BindingDB Entry DOI: 10.7270/Q28W3GBG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human)) | BDBM287616 (N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | 25 |
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.; Yangtze River Pharmaceutical Group Co., Ltd. US Patent | Assay Description All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas... | US Patent US10085983 (2018) BindingDB Entry DOI: 10.7270/Q28W3GBG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human)) | BDBM287610 (N-(5(7-cyclohexenyl-pyrrolo[1,2-f][1,2,4]triazin-2...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | 25 |
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.; Yangtze River Pharmaceutical Group Co., Ltd. US Patent | Assay Description All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas... | US Patent US10085983 (2018) BindingDB Entry DOI: 10.7270/Q28W3GBG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human)) | BDBM287618 (N-(2-(4-(dimethylamino)piperidin-1-yl)-4-methoxy-5...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | 25 |
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.; Yangtze River Pharmaceutical Group Co., Ltd. US Patent | Assay Description All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas... | US Patent US10085983 (2018) BindingDB Entry DOI: 10.7270/Q28W3GBG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human)) | BDBM50322823 ((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | 25 |
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.; Yangtze River Pharmaceutical Group Co., Ltd. US Patent | Assay Description All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas... | US Patent US10085983 (2018) BindingDB Entry DOI: 10.7270/Q28W3GBG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human)) | BDBM238272 (US9409887, I-3) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Celgene Avilomics Research, Inc. US Patent | Assay Description Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS... | US Patent US9409887 (2016) BindingDB Entry DOI: 10.7270/Q2028QDD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human)) | BDBM238273 (US9409887, I-4) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Celgene Avilomics Research, Inc. US Patent | Assay Description Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS... | US Patent US9409887 (2016) BindingDB Entry DOI: 10.7270/Q2028QDD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human)) | BDBM287619 (N-(2-(4-(dimethylamino)piperidin-1-yl)-4-methoxy-5...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | 25 |
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.; Yangtze River Pharmaceutical Group Co., Ltd. US Patent | Assay Description All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas... | US Patent US10085983 (2018) BindingDB Entry DOI: 10.7270/Q28W3GBG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human)) | BDBM287621 (N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | 25 |
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.; Yangtze River Pharmaceutical Group Co., Ltd. US Patent | Assay Description All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas... | US Patent US10085983 (2018) BindingDB Entry DOI: 10.7270/Q28W3GBG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human)) | BDBM287614 (N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | 25 |
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.; Yangtze River Pharmaceutical Group Co., Ltd. US Patent | Assay Description All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas... | US Patent US10085983 (2018) BindingDB Entry DOI: 10.7270/Q28W3GBG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human)) | BDBM50123163 (CHEMBL3622672 | US9388160, 12) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 22 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Teligene Ltd US Patent | Assay Description The assay was performed using Kinase-Glo Plus luminescence kinase assay kit (Promega). The compounds were diluted in 10% DMSO and 5 μl of the dilu... | US Patent US9388160 (2016) BindingDB Entry DOI: 10.7270/Q2T152J9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human)) | BDBM50123163 (CHEMBL3622672 | US9388160, 12) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Teligene Ltd US Patent | Assay Description The assay was performed using Kinase-Glo Plus luminescence kinase assay kit (Promega). The compounds were diluted in 10% DMSO and 5 μl of the dilu... | US Patent US9388160 (2016) BindingDB Entry DOI: 10.7270/Q2T152J9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human)) | BDBM287620 (N-(5(7-cyclopropylpyrrolo[1,2-f][1,2,4]triazin-2-y...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 262 | n/a | n/a | n/a | n/a | n/a | 25 |
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.; Yangtze River Pharmaceutical Group Co., Ltd. US Patent | Assay Description All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas... | US Patent US10085983 (2018) BindingDB Entry DOI: 10.7270/Q28W3GBG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human)) | BDBM287622 (The Preparation of N-(2-(4-(dimethylamino)piperidi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 294 | n/a | n/a | n/a | n/a | n/a | 25 |
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.; Yangtze River Pharmaceutical Group Co., Ltd. US Patent | Assay Description All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas... | US Patent US10085983 (2018) BindingDB Entry DOI: 10.7270/Q28W3GBG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human)) | BDBM238270 (US9409887, I-1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a |
Celgene Avilomics Research, Inc. US Patent | Assay Description A431 human epidermoid carcinoma, H1975 human NSCLC and HCC827 human NSCLC adenocarcinoma cells were obtained from the American Type Culture Center (M... | US Patent US9409887 (2016) BindingDB Entry DOI: 10.7270/Q2028QDD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [668-1210,T790M,L858R] (Homo sapiens (Human)) | BDBM238272 (US9409887, I-3) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 300 | n/a | n/a | n/a | n/a |
Celgene Avilomics Research, Inc. US Patent | Assay Description A431 human epidermoid carcinoma, H1975 human NSCLC and HCC827 human NSCLC adenocarcinoma cells were obtained from the American Type Culture Center (M... | US Patent US9409887 (2016) BindingDB Entry DOI: 10.7270/Q2028QDD | |||||||||||
More data for this Ligand-Target Pair |