Found 506 hits Enz. Inhib. hit(s) with Target = 'Gamma-aminobutyric acid receptor subunit alpha-6' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Gamma-aminobutyric acid receptor subunit alpha-6
(Homo sapiens (Human)) | BDBM23183
(5-(aminomethyl)-1,2-oxazol-3-ol | Agarin | CHEMBL2...)Show InChI InChI=1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7) | Reactome pathway KEGG
UniProtKB/SwissProt
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| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories
Curated by PDSP Ki Database
| |
Mol Pharmacol 52: 1150-6 (1997)
BindingDB Entry DOI: 10.7270/Q29C6VZC |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50034822
(8-Chloro-2-(4-methoxy-phenyl)-2,5-dihydro-pyrazolo...)Show SMILES COc1ccc(cc1)-n1[nH]c2c(cnc3ccc(Cl)cc23)c1=O Show InChI InChI=1S/C17H12ClN3O2/c1-23-12-5-3-11(4-6-12)21-17(22)14-9-19-15-7-2-10(18)8-13(15)16(14)20-21/h2-9,20H,1H3 | PDB
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| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2 |
J Med Chem 43: 71-95 (2000)
BindingDB Entry DOI: 10.7270/Q2W37X0J |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50459882
(CHEMBL4060185)Show SMILES COc1ccc(cc1)-n1nc2c(c[nH]c3ccc(Cl)cc23)c1=O Show InChI InChI=1S/C17H12ClN3O2/c1-23-12-5-3-11(4-6-12)21-17(22)14-9-19-15-7-2-10(18)8-13(15)16(14)20-21/h2-9,19H,1H3 | PDB
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| Article PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]Ro15-1788 from human GABAA receptor alpha6beta3gamma2 expressed in LTK cells preincubated for 30 secs measured every 15 mins at -... |
Bioorg Med Chem Lett 27: 3207-3218 (2017)
Article DOI: 10.1016/j.bmcl.2017.04.073 BindingDB Entry DOI: 10.7270/Q2MC92NR |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50034834
(7-Methoxy-2-phenyl-2,5-dihydro-pyrazolo[4,3-c]quin...)Show InChI InChI=1S/C17H13N3O2/c1-22-12-7-8-13-15(9-12)18-10-14-16(13)19-20(17(14)21)11-5-3-2-4-6-11/h2-10,19H,1H3 | PDB
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| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2 |
J Med Chem 43: 71-95 (2000)
BindingDB Entry DOI: 10.7270/Q2W37X0J |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-2/gamma-2
(RAT-Rattus norvegicus (Rat)) | BDBM50000766
(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)Show InChI InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3 | PDB
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| 2.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heidelberg
Curated by ChEMBL
| Assay Description Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr,gly,val)beta2gama2 subunits expressed in HEK293 cells |
J Med Chem 37: 4576-80 (1995)
BindingDB Entry DOI: 10.7270/Q2154HPB |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-6
(RAT) | BDBM50034835
(5-Methyl-6-oxo-5,6-dihydro-4H-7-thia-2,5,9b-triaza...)Show InChI InChI=1S/C15H17N3O3S/c1-15(2,3)21-14(20)11-10-7-17(4)13(19)12-9(5-6-22-12)18(10)8-16-11/h5-6,8H,7H2,1-4H3 | KEGG
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| 3.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes, Digestive, and Kidney Diseases
Curated by PDSP Ki Database
| |
Neuropharmacology 35: 1307-14 (1996)
Article DOI: 10.1016/s0028-3908(96)00054-8 BindingDB Entry DOI: 10.7270/Q28S4NF7 |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM26267
(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(ccc-21)N=[N+]=[N-] Show InChI InChI=1S/C15H14N6O3/c1-3-24-15(23)13-12-7-20(2)14(22)10-6-9(18-19-16)4-5-11(10)21(12)8-17-13/h4-6,8H,3,7H2,1-2H3 | PDB
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| 3.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description In vitro binding affinity for human GABA-A receptor alpha6-beta3-gamma2 subunits expressed in L(tk-) cell membranes |
J Med Chem 46: 5567-70 (2003)
Article DOI: 10.1021/jm034164c BindingDB Entry DOI: 10.7270/Q2R78DNC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM26267
(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(ccc-21)N=[N+]=[N-] Show InChI InChI=1S/C15H14N6O3/c1-3-24-15(23)13-12-7-20(2)14(22)10-6-9(18-19-16)4-5-11(10)21(12)8-17-13/h4-6,8H,3,7H2,1-2H3 | PDB
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| 3.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description Binding affinity against Gamma-aminobutyric-acid A receptor alpha6-beta3-gamma2 |
J Med Chem 41: 4130-42 (1998)
Article DOI: 10.1021/jm980317y BindingDB Entry DOI: 10.7270/Q2W37VFJ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM26267
(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(ccc-21)N=[N+]=[N-] Show InChI InChI=1S/C15H14N6O3/c1-3-24-15(23)13-12-7-20(2)14(22)10-6-9(18-19-16)4-5-11(10)21(12)8-17-13/h4-6,8H,3,7H2,1-2H3 | PDB
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| 3.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2 |
J Med Chem 43: 71-95 (2000)
BindingDB Entry DOI: 10.7270/Q2W37X0J |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM26267
(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(ccc-21)N=[N+]=[N-] Show InChI InChI=1S/C15H14N6O3/c1-3-24-15(23)13-12-7-20(2)14(22)10-6-9(18-19-16)4-5-11(10)21(12)8-17-13/h4-6,8H,3,7H2,1-2H3 | PDB
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| 3.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description Binding affinity for human GABA-A receptor alpha-6-beta-2-gamma-2 expressed in L(tk-) cell membranes |
J Med Chem 39: 1928-34 (1996)
Article DOI: 10.1021/jm950887n BindingDB Entry DOI: 10.7270/Q2K35SR6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50034816
(8-Chloro-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tri...)Show SMILES CN1Cc2c(ncn2-c2ccc(Cl)cc2C1=O)C(=O)OC(C)(C)C Show InChI InChI=1S/C17H18ClN3O3/c1-17(2,3)24-16(23)14-13-8-20(4)15(22)11-7-10(18)5-6-12(11)21(13)9-19-14/h5-7,9H,8H2,1-4H3 | PDB
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| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description Binding affinity against Gamma-aminobutyric-acid A receptor alpha6-beta3-gamma2 |
J Med Chem 41: 4130-42 (1998)
Article DOI: 10.1021/jm980317y BindingDB Entry DOI: 10.7270/Q2W37VFJ |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50083893
(8-Bromo-2-phenyl-2,5-dihydro-pyrazolo[4,3-c]quinol...)Show InChI InChI=1S/C16H10BrN3O/c17-10-6-7-14-12(8-10)15-13(9-18-14)16(21)20(19-15)11-4-2-1-3-5-11/h1-9,19H | PDB
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| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2 |
J Med Chem 43: 71-95 (2000)
BindingDB Entry DOI: 10.7270/Q2W37X0J |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50034816
(8-Chloro-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tri...)Show SMILES CN1Cc2c(ncn2-c2ccc(Cl)cc2C1=O)C(=O)OC(C)(C)C Show InChI InChI=1S/C17H18ClN3O3/c1-17(2,3)24-16(23)14-13-8-20(4)15(22)11-7-10(18)5-6-12(11)21(13)9-19-14/h5-7,9H,8H2,1-4H3 | PDB
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| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2 |
J Med Chem 43: 71-95 (2000)
BindingDB Entry DOI: 10.7270/Q2W37X0J |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50044951
(8-Iodo-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-triaz...)Show SMILES CN1Cc2c(ncn2-c2ccc(I)cc2C1=O)C(=O)OC(C)(C)C Show InChI InChI=1S/C17H18IN3O3/c1-17(2,3)24-16(23)14-13-8-20(4)15(22)11-7-10(18)5-6-12(11)21(13)9-19-14/h5-7,9H,8H2,1-4H3 | PDB
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| 4.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description Binding affinity against Gamma-aminobutyric-acid A receptor alpha6-beta3-gamma2 |
J Med Chem 41: 4130-42 (1998)
Article DOI: 10.1021/jm980317y BindingDB Entry DOI: 10.7270/Q2W37VFJ |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50044951
(8-Iodo-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-triaz...)Show SMILES CN1Cc2c(ncn2-c2ccc(I)cc2C1=O)C(=O)OC(C)(C)C Show InChI InChI=1S/C17H18IN3O3/c1-17(2,3)24-16(23)14-13-8-20(4)15(22)11-7-10(18)5-6-12(11)21(13)9-19-14/h5-7,9H,8H2,1-4H3 | PDB
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| 4.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2 |
J Med Chem 43: 71-95 (2000)
BindingDB Entry DOI: 10.7270/Q2W37X0J |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6
(Homo sapiens (Human)) | BDBM50049736
(8-Ethynyl-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tr...)Show SMILES CN1Cc2c(ncn2-c2ccc(cc2C1=O)C#C)C(=O)OC(C)(C)C Show InChI InChI=1S/C19H19N3O3/c1-6-12-7-8-14-13(9-12)17(23)21(5)10-15-16(20-11-22(14)15)18(24)25-19(2,3)4/h1,7-9,11H,10H2,2-5H3 | Reactome pathway KEGG
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| 5.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Moltech Corporation
Curated by ChEMBL
| Assay Description Binding affinity to GABAA alpha-6-beta-3-gamma-2 receptor |
J Med Chem 51: 3788-803 (2008)
Article DOI: 10.1021/jm701433b BindingDB Entry DOI: 10.7270/Q2FQ9XH6 |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50049736
(8-Ethynyl-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tr...)Show SMILES CN1Cc2c(ncn2-c2ccc(cc2C1=O)C#C)C(=O)OC(C)(C)C Show InChI InChI=1S/C19H19N3O3/c1-6-12-7-8-14-13(9-12)17(23)21(5)10-15-16(20-11-22(14)15)18(24)25-19(2,3)4/h1,7-9,11H,10H2,2-5H3 | PDB
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| 5.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description Binding affinity against Gamma-aminobutyric-acid A receptor alpha6-beta3-gamma2 |
J Med Chem 41: 4130-42 (1998)
Article DOI: 10.1021/jm980317y BindingDB Entry DOI: 10.7270/Q2W37VFJ |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50049736
(8-Ethynyl-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tr...)Show SMILES CN1Cc2c(ncn2-c2ccc(cc2C1=O)C#C)C(=O)OC(C)(C)C Show InChI InChI=1S/C19H19N3O3/c1-6-12-7-8-14-13(9-12)17(23)21(5)10-15-16(20-11-22(14)15)18(24)25-19(2,3)4/h1,7-9,11H,10H2,2-5H3 | PDB
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| 5.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description In vitro binding affinity for human GABA-A receptor alpha6-beta3-gamma2 subunits expressed in L(tk-) cell membranes |
J Med Chem 46: 5567-70 (2003)
Article DOI: 10.1021/jm034164c BindingDB Entry DOI: 10.7270/Q2R78DNC |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6 [20-453]/beta-2 [26-512]/gamma-2 [40-467]
(Homo sapiens (Human)) | BDBM26267
(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(ccc-21)N=[N+]=[N-] Show InChI InChI=1S/C15H14N6O3/c1-3-24-15(23)13-12-7-20(2)14(22)10-6-9(18-19-16)4-5-11(10)21(12)8-17-13/h4-6,8H,3,7H2,1-2H3 | PDB
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| 5.10 | -46.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
University of Wisconsin at Madison
| Assay Description Membrane homogenates were incubated at room temperature with a sub-Kd concentration of radioligand in the absence or presence of seven different conc... |
J Med Chem 51: 7243-52 (2008)
Article DOI: 10.1021/jm800889m BindingDB Entry DOI: 10.7270/Q2R78CJM |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50049736
(8-Ethynyl-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tr...)Show SMILES CN1Cc2c(ncn2-c2ccc(cc2C1=O)C#C)C(=O)OC(C)(C)C Show InChI InChI=1S/C19H19N3O3/c1-6-12-7-8-14-13(9-12)17(23)21(5)10-15-16(20-11-22(14)15)18(24)25-19(2,3)4/h1,7-9,11H,10H2,2-5H3 | PDB
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| 5.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description Binding affinity for human GABA-A receptor alpha-6-beta-2-gamma-2 expressed in L(tk-) cell membranes |
J Med Chem 39: 1928-34 (1996)
Article DOI: 10.1021/jm950887n BindingDB Entry DOI: 10.7270/Q2K35SR6 |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50049736
(8-Ethynyl-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tr...)Show SMILES CN1Cc2c(ncn2-c2ccc(cc2C1=O)C#C)C(=O)OC(C)(C)C Show InChI InChI=1S/C19H19N3O3/c1-6-12-7-8-14-13(9-12)17(23)21(5)10-15-16(20-11-22(14)15)18(24)25-19(2,3)4/h1,7-9,11H,10H2,2-5H3 | PDB
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| 5.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2 |
J Med Chem 43: 71-95 (2000)
BindingDB Entry DOI: 10.7270/Q2W37X0J |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50044941
(8-Azido-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tria...)Show SMILES CN1Cc2c(ncn2-c2ccc(cc2C1=O)N=[N+]=[N-])C(=O)OC(C)(C)C Show InChI InChI=1S/C17H18N6O3/c1-17(2,3)26-16(25)14-13-8-22(4)15(24)11-7-10(20-21-18)5-6-12(11)23(13)9-19-14/h5-7,9H,8H2,1-4H3 | PDB
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UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 5.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description Binding affinity against Gamma-aminobutyric-acid A receptor alpha6-beta3-gamma2 |
J Med Chem 41: 4130-42 (1998)
Article DOI: 10.1021/jm980317y BindingDB Entry DOI: 10.7270/Q2W37VFJ |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6
(RAT) | BDBM50044941
(8-Azido-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tria...)Show SMILES CN1Cc2c(ncn2-c2ccc(cc2C1=O)N=[N+]=[N-])C(=O)OC(C)(C)C Show InChI InChI=1S/C17H18N6O3/c1-17(2,3)26-16(25)14-13-8-22(4)15(24)11-7-10(20-21-18)5-6-12(11)23(13)9-19-14/h5-7,9H,8H2,1-4H3 | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 5.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes, Digestive, and Kidney Diseases
Curated by PDSP Ki Database
| |
Neuropharmacology 35: 1307-14 (1996)
Article DOI: 10.1016/s0028-3908(96)00054-8 BindingDB Entry DOI: 10.7270/Q28S4NF7 |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50044941
(8-Azido-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tria...)Show SMILES CN1Cc2c(ncn2-c2ccc(cc2C1=O)N=[N+]=[N-])C(=O)OC(C)(C)C Show InChI InChI=1S/C17H18N6O3/c1-17(2,3)26-16(25)14-13-8-22(4)15(24)11-7-10(20-21-18)5-6-12(11)23(13)9-19-14/h5-7,9H,8H2,1-4H3 | PDB
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UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 5.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2 |
J Med Chem 43: 71-95 (2000)
BindingDB Entry DOI: 10.7270/Q2W37X0J |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6
(RAT) | BDBM26267
(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(ccc-21)N=[N+]=[N-] Show InChI InChI=1S/C15H14N6O3/c1-3-24-15(23)13-12-7-20(2)14(22)10-6-9(18-19-16)4-5-11(10)21(12)8-17-13/h4-6,8H,3,7H2,1-2H3 | KEGG
UniProtKB/SwissProt
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| Article PubMed
| 5.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes, Digestive, and Kidney Diseases
Curated by PDSP Ki Database
| |
Neuropharmacology 35: 1307-14 (1996)
Article DOI: 10.1016/s0028-3908(96)00054-8 BindingDB Entry DOI: 10.7270/Q28S4NF7 |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6
(Homo sapiens (Human)) | BDBM23183
(5-(aminomethyl)-1,2-oxazol-3-ol | Agarin | CHEMBL2...)Show InChI InChI=1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7) | Reactome pathway KEGG
UniProtKB/SwissProt
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| PubMed
| 5.37 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories
Curated by PDSP Ki Database
| |
Mol Pharmacol 52: 1150-6 (1997)
BindingDB Entry DOI: 10.7270/Q29C6VZC |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM26267
(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(ccc-21)N=[N+]=[N-] Show InChI InChI=1S/C15H14N6O3/c1-3-24-15(23)13-12-7-20(2)14(22)10-6-9(18-19-16)4-5-11(10)21(12)8-17-13/h4-6,8H,3,7H2,1-2H3 | PDB
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| PDB Article PubMed
| 5.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Upjohn Laboratories
Curated by ChEMBL
| Assay Description Displacement of [3H]Ro-154513 from GABA-A receptor alpha-6-beta-2-gamma-2 subunits expressed in Sf9 cells |
J Med Chem 39: 158-75 (1996)
Article DOI: 10.1021/jm940765f BindingDB Entry DOI: 10.7270/Q2PZ57WX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM26267
(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(ccc-21)N=[N+]=[N-] Show InChI InChI=1S/C15H14N6O3/c1-3-24-15(23)13-12-7-20(2)14(22)10-6-9(18-19-16)4-5-11(10)21(12)8-17-13/h4-6,8H,3,7H2,1-2H3 | PDB
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Similars
| PDB PubMed
| 5.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Upjohn Laboratories
Curated by ChEMBL
| Assay Description Displacement of [3H]-Ro- 15-4513 from alpha-6-beta-2-gamma-2 GABA-A receptor subunits expressed in Sf9 cell membranes |
J Med Chem 37: 758-68 (1994)
BindingDB Entry DOI: 10.7270/Q27W6B8R |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-6
(Homo sapiens (Human)) | BDBM85196
(CAS_5448 | NSC_5448 | Thiomuscimol)Show InChI InChI=1S/C4H6N2OS/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7) | Reactome pathway KEGG
UniProtKB/SwissProt
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PC cid PC sid UniChem
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| PubMed
| 5.62 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories
Curated by PDSP Ki Database
| |
Mol Pharmacol 52: 1150-6 (1997)
BindingDB Entry DOI: 10.7270/Q29C6VZC |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-2/gamma-2
(RAT-Rattus norvegicus (Rat)) | BDBM50001478
(9H-beta-Carboline-3-carboxylic acid methyl ester |...)Show InChI InChI=1S/C13H10N2O2/c1-17-13(16)11-6-9-8-4-2-3-5-10(8)15-12(9)7-14-11/h2-7,14H,1H3 | PDB
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| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heidelberg
Curated by ChEMBL
| Assay Description Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr)beta2gama2 subunits expressed in HEK293 cells |
J Med Chem 37: 4576-80 (1995)
BindingDB Entry DOI: 10.7270/Q2154HPB |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50067441
(8-Hydroxy-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tr...)Show SMILES CN1Cc2c(ncn2-c2ccc(O)cc2C1=O)C(=O)OC(C)(C)C Show InChI InChI=1S/C17H19N3O4/c1-17(2,3)24-16(23)14-13-8-19(4)15(22)11-7-10(21)5-6-12(11)20(13)9-18-14/h5-7,9,21H,8H2,1-4H3 | PDB
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antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 6.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2 |
J Med Chem 43: 71-95 (2000)
BindingDB Entry DOI: 10.7270/Q2W37X0J |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50067441
(8-Hydroxy-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tr...)Show SMILES CN1Cc2c(ncn2-c2ccc(O)cc2C1=O)C(=O)OC(C)(C)C Show InChI InChI=1S/C17H19N3O4/c1-17(2,3)24-16(23)14-13-8-19(4)15(22)11-7-10(21)5-6-12(11)20(13)9-18-14/h5-7,9,21H,8H2,1-4H3 | PDB
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| CHEMBL PC cid PC sid UniChem
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| Article PubMed
| 6.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description Binding affinity against Gamma-aminobutyric-acid A receptor alpha6-beta3-gamma2 |
J Med Chem 41: 4130-42 (1998)
Article DOI: 10.1021/jm980317y BindingDB Entry DOI: 10.7270/Q2W37VFJ |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-2/gamma-2
(RAT-Rattus norvegicus (Rat)) | BDBM50001478
(9H-beta-Carboline-3-carboxylic acid methyl ester |...)Show InChI InChI=1S/C13H10N2O2/c1-17-13(16)11-6-9-8-4-2-3-5-10(8)15-12(9)7-14-11/h2-7,14H,1H3 | PDB
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| PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heidelberg
Curated by ChEMBL
| Assay Description Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr,gly)beta2gama2 subunits expressed in HEK293 cells |
J Med Chem 37: 4576-80 (1995)
BindingDB Entry DOI: 10.7270/Q2154HPB |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-2/gamma-2
(RAT-Rattus norvegicus (Rat)) | BDBM50035527
(3-Methyl-9H-beta-carboline | CHEMBL344859)Show InChI InChI=1S/C12H10N2/c1-8-6-10-9-4-2-3-5-11(9)14-12(10)7-13-8/h2-7,13H,1H3 | PDB
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| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heidelberg
Curated by ChEMBL
| Assay Description Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr,gly)beta2gama2 subunits expressed in HEK293 cells |
J Med Chem 37: 4576-80 (1995)
BindingDB Entry DOI: 10.7270/Q2154HPB |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6
(RAT) | BDBM50034816
(8-Chloro-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tri...)Show SMILES CN1Cc2c(ncn2-c2ccc(Cl)cc2C1=O)C(=O)OC(C)(C)C Show InChI InChI=1S/C17H18ClN3O3/c1-17(2,3)24-16(23)14-13-8-20(4)15(22)11-7-10(18)5-6-12(11)21(13)9-19-14/h5-7,9H,8H2,1-4H3 | KEGG
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 8.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes, Digestive, and Kidney Diseases
Curated by PDSP Ki Database
| |
Neuropharmacology 35: 1307-14 (1996)
Article DOI: 10.1016/s0028-3908(96)00054-8 BindingDB Entry DOI: 10.7270/Q28S4NF7 |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50067429
(8-Methoxy-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tr...)Show SMILES COc1ccc-2c(c1)C(=O)N(C)Cc1c(ncn-21)C(=O)OC(C)(C)C Show InChI InChI=1S/C18H21N3O4/c1-18(2,3)25-17(23)15-14-9-20(4)16(22)12-8-11(24-5)6-7-13(12)21(14)10-19-15/h6-8,10H,9H2,1-5H3 | PDB
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antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 8.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description Binding affinity against Gamma-aminobutyric-acid A receptor alpha6-beta3-gamma2 |
J Med Chem 41: 4130-42 (1998)
Article DOI: 10.1021/jm980317y BindingDB Entry DOI: 10.7270/Q2W37VFJ |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50067429
(8-Methoxy-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tr...)Show SMILES COc1ccc-2c(c1)C(=O)N(C)Cc1c(ncn-21)C(=O)OC(C)(C)C Show InChI InChI=1S/C18H21N3O4/c1-18(2,3)25-17(23)15-14-9-20(4)16(22)12-8-11(24-5)6-7-13(12)21(14)10-19-15/h6-8,10H,9H2,1-5H3 | PDB
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UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 8.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2 |
J Med Chem 43: 71-95 (2000)
BindingDB Entry DOI: 10.7270/Q2W37X0J |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-2/gamma-2
(RAT-Rattus norvegicus (Rat)) | BDBM50000766
(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)Show InChI InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3 | PDB
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| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heidelberg
Curated by ChEMBL
| Assay Description Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr,gly)beta2gama2 subunits expressed in HEK293 cells |
J Med Chem 37: 4576-80 (1995)
BindingDB Entry DOI: 10.7270/Q2154HPB |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50044947
(8-Bromo-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tria...)Show SMILES CN1Cc2c(ncn2-c2ccc(Br)cc2C1=O)C(=O)OC(C)(C)C Show InChI InChI=1S/C17H18BrN3O3/c1-17(2,3)24-16(23)14-13-8-20(4)15(22)11-7-10(18)5-6-12(11)21(13)9-19-14/h5-7,9H,8H2,1-4H3 | PDB
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antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
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| Article PubMed
| 9.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description Binding affinity for human GABA-A receptor alpha-6-beta-2-gamma-2 expressed in L(tk-) cell membranes |
J Med Chem 39: 1928-34 (1996)
Article DOI: 10.1021/jm950887n BindingDB Entry DOI: 10.7270/Q2K35SR6 |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50044947
(8-Bromo-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tria...)Show SMILES CN1Cc2c(ncn2-c2ccc(Br)cc2C1=O)C(=O)OC(C)(C)C Show InChI InChI=1S/C17H18BrN3O3/c1-17(2,3)24-16(23)14-13-8-20(4)15(22)11-7-10(18)5-6-12(11)21(13)9-19-14/h5-7,9H,8H2,1-4H3 | PDB
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antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
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| Article PubMed
| 9.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description Binding affinity against Gamma-aminobutyric-acid A receptor alpha6-beta3-gamma2 |
J Med Chem 41: 4130-42 (1998)
Article DOI: 10.1021/jm980317y BindingDB Entry DOI: 10.7270/Q2W37VFJ |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50044947
(8-Bromo-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tria...)Show SMILES CN1Cc2c(ncn2-c2ccc(Br)cc2C1=O)C(=O)OC(C)(C)C Show InChI InChI=1S/C17H18BrN3O3/c1-17(2,3)24-16(23)14-13-8-20(4)15(22)11-7-10(18)5-6-12(11)21(13)9-19-14/h5-7,9H,8H2,1-4H3 | PDB
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antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
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Similars
| PubMed
| 9.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2 |
J Med Chem 43: 71-95 (2000)
BindingDB Entry DOI: 10.7270/Q2W37X0J |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-2/gamma-2
(RAT-Rattus norvegicus (Rat)) | BDBM50001478
(9H-beta-Carboline-3-carboxylic acid methyl ester |...)Show InChI InChI=1S/C13H10N2O2/c1-17-13(16)11-6-9-8-4-2-3-5-10(8)15-12(9)7-14-11/h2-7,14H,1H3 | PDB
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CHEMBL PC cid PC sid UniChem
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| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heidelberg
Curated by ChEMBL
| Assay Description Binding affinity for rat GABA-A receptor alpha-6-beta-2-gamma-2 subunits expressed in HEK293 cells |
J Med Chem 37: 4576-80 (1995)
BindingDB Entry DOI: 10.7270/Q2154HPB |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM85038
(CHEMBL43948 | PZII-029)Show SMILES COc1ccc(cc1)-n1[nH]c2c(cnc3cc(OC)ccc23)c1=O Show InChI InChI=1S/C18H15N3O3/c1-23-12-5-3-11(4-6-12)21-18(22)15-10-19-16-9-13(24-2)7-8-14(16)17(15)20-21/h3-10,20H,1-2H3 | PDB
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| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2 |
J Med Chem 43: 71-95 (2000)
BindingDB Entry DOI: 10.7270/Q2W37X0J |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM85042
(CHEMBL44613 | PW-007A)Show InChI InChI=1S/C17H13N3O2/c1-22-12-7-8-15-13(9-12)16-14(10-18-15)17(21)20(19-16)11-5-3-2-4-6-11/h2-10,19H,1H3 | PDB
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| >10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2 |
J Med Chem 43: 71-95 (2000)
BindingDB Entry DOI: 10.7270/Q2W37X0J |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-2/gamma-2
(RAT-Rattus norvegicus (Rat)) | BDBM50035527
(3-Methyl-9H-beta-carboline | CHEMBL344859)Show InChI InChI=1S/C12H10N2/c1-8-6-10-9-4-2-3-5-11(9)14-12(10)7-13-8/h2-7,13H,1H3 | PDB
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UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
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| PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heidelberg
Curated by ChEMBL
| Assay Description Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr,gly,val)beta2gama2 subunits expressed in HEK293 cells |
J Med Chem 37: 4576-80 (1995)
BindingDB Entry DOI: 10.7270/Q2154HPB |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6
(Homo sapiens (Human)) | BDBM26267
(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(ccc-21)N=[N+]=[N-] Show InChI InChI=1S/C15H14N6O3/c1-3-24-15(23)13-12-7-20(2)14(22)10-6-9(18-19-16)4-5-11(10)21(12)8-17-13/h4-6,8H,3,7H2,1-2H3 | Reactome pathway KEGG
UniProtKB/SwissProt
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| 11.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CoCensys, Inc.
Curated by PDSP Ki Database
| |
Eur J Pharmacol 291: 319-25 (1995)
Article DOI: 10.1016/0922-4106(95)90072-1 BindingDB Entry DOI: 10.7270/Q2JD4VB2 |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6
(Homo sapiens (Human)) | BDBM50017320
(8-Bromo-7-oxo-3b,4,5,6-tetrahydro-7H-2,6a,11b-tria...)Show SMILES CC(C)(C)OC(=O)c1ncn-2c1C1CCCN1C(=O)c1c(Br)cccc-21 Show InChI InChI=1S/C19H20BrN3O3/c1-19(2,3)26-18(25)15-16-13-8-5-9-22(13)17(24)14-11(20)6-4-7-12(14)23(16)10-21-15/h4,6-7,10,13H,5,8-9H2,1-3H3 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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| 12.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Research Laboratories
Curated by PDSP Ki Database
| |
Mol Pharmacol 49: 253-9 (1996)
BindingDB Entry DOI: 10.7270/Q2639N8C |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2
(Homo sapiens (Human)) | BDBM50083908
(8-Bromo-7-oxo-3b,4,5,6-tetrahydro-7H-2,6a,11b-tria...)Show SMILES CC(C)(C)OC(=O)c1ncn-2c1[C@@H]1CCCN1C(=O)c1c(Br)cccc-21 Show InChI InChI=1S/C19H20BrN3O3/c1-19(2,3)26-18(25)15-16-13-8-5-9-22(13)17(24)14-11(20)6-4-7-12(14)23(16)10-21-15/h4,6-7,10,13H,5,8-9H2,1-3H3/t13-/m0/s1 | PDB
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| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Milwaukee
Curated by ChEMBL
| Assay Description Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2 |
J Med Chem 43: 71-95 (2000)
BindingDB Entry DOI: 10.7270/Q2W37X0J |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50048831
(CHEMBL50763 | [3-(5-Cyclopropyl-[1,2,4]oxadiazol-3...)Show SMILES Fc1cccc-2c1N(Cc1c(ncn-21)-c1noc(n1)C1CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C20H19FN6O3/c21-13-2-1-3-14-17(13)26(20(28)25-6-8-29-9-7-25)10-15-16(22-11-27(14)15)18-23-19(30-24-18)12-4-5-12/h1-3,11-12H,4-10H2 | PDB
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antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
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| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Upjohn Laboratories
Curated by ChEMBL
| Assay Description Displacement of [3H]-Ro-15-4513 from GABA-A receptor alpha-6-beta-2-gamma-2 subunits expressed in Sf9 cells |
J Med Chem 39: 158-75 (1996)
Article DOI: 10.1021/jm940765f BindingDB Entry DOI: 10.7270/Q2PZ57WX |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-6/beta-2/gamma-2
(RAT-Rattus norvegicus (Rat)) | BDBM50048855
(3-(5-Cyclopropyl-[1,2,4]oxadiazol-3-yl)-4H-imidazo...)Show SMILES CN(C)C(=O)N1Cc2c(ncn2-c2ccccc12)-c1noc(n1)C1CC1 Show InChI InChI=1S/C18H18N6O2/c1-22(2)18(25)23-9-14-15(16-20-17(26-21-16)11-7-8-11)19-10-24(14)13-6-4-3-5-12(13)23/h3-6,10-11H,7-9H2,1-2H3 | PDB
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| 13.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Upjohn Laboratories
Curated by ChEMBL
| Assay Description Displacement of [3H]-Ro- 15-4513 from alpha6 beta2 gamma2 subunits of Rat GABA-A receptor expressed in Sf-9 insect cell membranes |
J Med Chem 39: 4654-66 (1996)
Article DOI: 10.1021/jm960401i BindingDB Entry DOI: 10.7270/Q20K27NN |
More data for this Ligand-Target Pair | |