Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Macrophage colony-stimulating factor 1 receptor [538-972] (Homo sapiens (Human)) | BDBM181020 (US9133183, Example 29) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Deciphera Pharmaceuticals, LLC US Patent | Assay Description Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A... | US Patent US9133183 (2015) BindingDB Entry DOI: 10.7270/Q2DN43TD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage colony-stimulating factor 1 receptor [538-972] (Homo sapiens (Human)) | BDBM181019 (US9133183, Example 15) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Deciphera Pharmaceuticals, LLC US Patent | Assay Description Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A... | US Patent US9133183 (2015) BindingDB Entry DOI: 10.7270/Q2DN43TD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage colony-stimulating factor 1 receptor [538-972] (Homo sapiens (Human)) | BDBM181027 (US9133183, Example 90) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Deciphera Pharmaceuticals, LLC US Patent | Assay Description Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A... | US Patent US9133183 (2015) BindingDB Entry DOI: 10.7270/Q2DN43TD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage colony-stimulating factor 1 receptor [538-972] (Homo sapiens (Human)) | BDBM181018 (US9133183, Example 1) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Deciphera Pharmaceuticals, LLC US Patent | Assay Description Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A... | US Patent US9133183 (2015) BindingDB Entry DOI: 10.7270/Q2DN43TD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage colony-stimulating factor 1 receptor [538-972] (Homo sapiens (Human)) | BDBM181034 (US9133183, Example 91) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Deciphera Pharmaceuticals, LLC US Patent | Assay Description Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A... | US Patent US9133183 (2015) BindingDB Entry DOI: 10.7270/Q2DN43TD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage colony-stimulating factor 1 receptor [538-972] (Homo sapiens (Human)) | BDBM181035 (US9133183, Example 101) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Deciphera Pharmaceuticals, LLC US Patent | Assay Description Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A... | US Patent US9133183 (2015) BindingDB Entry DOI: 10.7270/Q2DN43TD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage colony-stimulating factor 1 receptor [538-972] (Homo sapiens (Human)) | BDBM181037 (US9133183, Example 42) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 8 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Deciphera Pharmaceuticals, LLC US Patent | Assay Description Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A... | US Patent US9133183 (2015) BindingDB Entry DOI: 10.7270/Q2DN43TD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage colony-stimulating factor 1 receptor [538-972] (Homo sapiens (Human)) | BDBM181023 (US9133183, Compound A) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 13 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Deciphera Pharmaceuticals, LLC US Patent | Assay Description Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A... | US Patent US9133183 (2015) BindingDB Entry DOI: 10.7270/Q2DN43TD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage colony-stimulating factor 1 receptor [538-972] (Homo sapiens (Human)) | BDBM181026 (US9133183, Example 18) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 20 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Deciphera Pharmaceuticals, LLC US Patent | Assay Description Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A... | US Patent US9133183 (2015) BindingDB Entry DOI: 10.7270/Q2DN43TD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage colony-stimulating factor 1 receptor [538-972] () | BDBM2579 ((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 57 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Johnson & Johnson Pharmaceutical | Assay Description The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e... | J Biol Chem 282: 4085-93 (2007) Article DOI: 10.1074/jbc.M608182200 BindingDB Entry DOI: 10.7270/Q2NK3C8N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage colony-stimulating factor 1 receptor [538-972] () | BDBM17015 ((3Z)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Johnson & Johnson Pharmaceutical | Assay Description The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e... | J Biol Chem 282: 4085-93 (2007) Article DOI: 10.1074/jbc.M608182200 BindingDB Entry DOI: 10.7270/Q2NK3C8N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage colony-stimulating factor 1 receptor [538-972] () | BDBM17749 (JNJ31117164) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | Article PubMed | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Johnson & Johnson Pharmaceutical | Assay Description The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e... | J Biol Chem 282: 4085-93 (2007) Article DOI: 10.1074/jbc.M608182200 BindingDB Entry DOI: 10.7270/Q2NK3C8N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage colony-stimulating factor 1 receptor [538-972] () | BDBM4363 ((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethio...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Johnson & Johnson Pharmaceutical | Assay Description The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e... | J Biol Chem 282: 4085-93 (2007) Article DOI: 10.1074/jbc.M608182200 BindingDB Entry DOI: 10.7270/Q2NK3C8N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage colony-stimulating factor 1 receptor [538-972] () | BDBM17747 ((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.70E+3 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Johnson & Johnson Pharmaceutical | Assay Description The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e... | J Biol Chem 282: 4085-93 (2007) Article DOI: 10.1074/jbc.M608182200 BindingDB Entry DOI: 10.7270/Q2NK3C8N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage colony-stimulating factor 1 receptor [538-972] () | BDBM7393 (3-[(2Z,3E)-3-(hydroxyimino)-2,3-dihydro-1H-indol-2...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Johnson & Johnson Pharmaceutical | Assay Description The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e... | J Biol Chem 282: 4085-93 (2007) Article DOI: 10.1074/jbc.M608182200 BindingDB Entry DOI: 10.7270/Q2NK3C8N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage colony-stimulating factor 1 receptor [538-972] () | BDBM17748 (2-(3,4-Dihydroxyphenyl)-6,7-dimethylquinoxaline | ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Johnson & Johnson Pharmaceutical | Assay Description The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e... | J Biol Chem 282: 4085-93 (2007) Article DOI: 10.1074/jbc.M608182200 BindingDB Entry DOI: 10.7270/Q2NK3C8N | |||||||||||
More data for this Ligand-Target Pair |