Found 145 hits Enz. Inhib. hit(s) with Target = 'Acetylcholine receptor subunit alpha/beta/delta/gamma' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50049757
(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2 | PDB
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| 2.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding potency for Nicotinic acetylcholine receptor alpha-7 (rat brain) |
J Med Chem 40: 4169-94 (1998)
Article DOI: 10.1021/jm970377o
BindingDB Entry DOI: 10.7270/Q2QF8TH9 |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50038413
(CHEMBL136284 | N,N'-(2,3-dihydroxylbenzyl)-N,N,N',...)Show SMILES C[N+](C)(CCCCCC[N+](C)(C)Cc1cccc(O)c1O)Cc1cccc(O)c1O Show InChI InChI=1S/C24H36N2O4/c1-25(2,17-19-11-9-13-21(27)23(19)29)15-7-5-6-8-16-26(3,4)18-20-12-10-14-22(28)24(20)30/h9-14H,5-8,15-18H2,1-4H3,(H2-2,27,28,29,30)/p+2 | PDB
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| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toledo
Curated by ChEMBL
| Assay Description
Binding affinity against nicotinic acetylcholine receptor (nAChR) |
J Med Chem 37: 4417-20 (1995)
Checked by Author
BindingDB Entry DOI: 10.7270/Q24F1PS9 |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50143282
((-)-cytisine | (1R,5S)-1,2,3,4,5,6-Hexahydro-1,5-m...)Show InChI InChI=1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2/t8?,9-/m1/s1 | PDB
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| 250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha1 beta gamma delta of electroplax |
J Med Chem 48: 3474-7 (2005)
Article DOI: 10.1021/jm050069n
BindingDB Entry DOI: 10.7270/Q2N87BJ7 |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50061562
((12R,13aR)-12-Methoxy-1,4,5,6,9,11,12,13-octahydro...)Show SMILES CO[C@@H]1CC=C2CCN3CCC4=C(CC(=O)OC4)[C@@]23C1 |t:4,11| Show InChI InChI=1S/C16H21NO3/c1-19-13-3-2-12-5-7-17-6-4-11-10-20-15(18)8-14(11)16(12,17)9-13/h2,13H,3-10H2,1H3/t13-,16-/m1/s1 | PDB
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| 314 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Affinity for Nicotinic acetylcholine receptor alpha4-beta2 in rat brain |
J Med Chem 40: 4169-94 (1998)
Article DOI: 10.1021/jm970377o
BindingDB Entry DOI: 10.7270/Q2QF8TH9 |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50220046
(CHEMBL382243 | trimethyl({20-[(trimethylazaniumyl)...)Show SMILES C[N+](C)(C)Cc1c2Cn3c(Cn2c2ccccc12)c(C[N+](C)(C)C)c1ccccc31 Show InChI InChI=1S/C26H34N4/c1-29(2,3)17-21-19-11-7-9-13-23(19)27-16-26-22(18-30(4,5)6)20-12-8-10-14-24(20)28(26)15-25(21)27/h7-14H,15-18H2,1-6H3/q+2 | PDB
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| 331 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of W£rzburg
Curated by ChEMBL
| Assay Description
Displacement of (+/-)-[3H]epibatidine from muscle type nAChR of Torpedo californica in hepes buffer |
Bioorg Med Chem Lett 16: 1481-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.030
BindingDB Entry DOI: 10.7270/Q2D50QQ5 |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50166909
(10-Aza-tricyclo[6.3.1.0*2,7*]dodeca-2(7),3,5-trien...)Show InChI InChI=1S/C11H13N/c1-2-4-11-9-5-8(6-12-7-9)10(11)3-1/h1-4,8-9,12H,5-7H2 | PDB
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| 370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha1 beta gamma delta of electroplax |
J Med Chem 48: 3474-7 (2005)
Article DOI: 10.1021/jm050069n
BindingDB Entry DOI: 10.7270/Q2N87BJ7 |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50220045
(CHEMBL206666 | [(20-{[dimethyl(prop-2-en-1-yl)azan...)Show SMILES C[N+](C)(CC=C)Cc1c2Cn3c(Cn2c2ccccc12)c(C[N+](C)(C)CC=C)c1ccccc31 Show InChI InChI=1S/C30H38N4/c1-7-17-33(3,4)21-25-23-13-9-11-15-27(23)31-20-30-26(22-34(5,6)18-8-2)24-14-10-12-16-28(24)32(30)19-29(25)31/h7-16H,1-2,17-22H2,3-6H3/q+2 | PDB
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| 550 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of W£rzburg
Curated by ChEMBL
| Assay Description
Displacement of (+/-)-[3H]epibatidine from muscle type nAChR of Torpedo californica in hepes buffer |
Bioorg Med Chem Lett 16: 1481-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.030
BindingDB Entry DOI: 10.7270/Q2D50QQ5 |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50166907
(4-nitro-10-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-...)Show InChI InChI=1S/C11H12N2O2/c14-13(15)9-1-2-10-7-3-8(6-12-5-7)11(10)4-9/h1-2,4,7-8,12H,3,5-6H2 | PDB
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| 690 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha1 beta gamma delta of electroplax |
J Med Chem 48: 3474-7 (2005)
Article DOI: 10.1021/jm050069n
BindingDB Entry DOI: 10.7270/Q2N87BJ7 |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50475690
(4,4''-Diallylcaracurinium V Dibromide | Diallylcar...)Show SMILES [Br-].[Br-].[H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])N6c7ccccc7[C@@]78CC[N+]9(CC=C)CC%10=CCO[C@@]([H])(N%11c%12ccccc%12[C@@]1(CC[N+]2(CC=C)C4)[C@]%11([H])[C@@]35[H])[C@@]([H])([C@]67[H])[C@@]%10([H])C[C@@]89[H] |r,c:5,t:27| Show InChI InChI=1S/C44H50N4O2.2BrH/c1-3-17-47-19-15-43-31-9-5-7-11-33(31)45-39(43)37-29(23-35(43)47)27(25-47)13-21-49-41(37)46-34-12-8-6-10-32(34)44-16-20-48(18-4-2)26-28-14-22-50-42(45)38(40(44)46)30(28)24-36(44)48;;/h3-14,29-30,35-42H,1-2,15-26H2;2*1H/q+2;;/p-2/t29-,30-,35-,36-,37+,38+,39-,40-,41+,42+,43+,44+,47?,48?;;/m0../s1 | PDB
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| PC cid
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| 1.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of W£rzburg
Curated by ChEMBL
| Assay Description
Displacement of (+/-)-[3H]epibatidine from muscle type nAChR of Torpedo californica in hepes buffer |
Bioorg Med Chem Lett 16: 1481-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.030
BindingDB Entry DOI: 10.7270/Q2D50QQ5 |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Homo sapiens (Human)) | BDBM50096712
(3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-...)Show SMILES C[N+]1(C)C2CCC1CC(C2)OC(=O)c1c[nH]c2ccccc12 |TLB:10:8:1:4.5| Show InChI InChI=1S/C18H22N2O2/c1-20(2)12-7-8-13(20)10-14(9-12)22-18(21)16-11-19-17-6-4-3-5-15(16)17/h3-6,11-14H,7-10H2,1-2H3/p+1 | PDB
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| 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
In vitro Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 was determined |
Bioorg Med Chem Lett 11: 319-21 (2001)
BindingDB Entry DOI: 10.7270/Q2028S36 |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50166908
(5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca...)Show InChI InChI=1S/C13H13N3/c1-2-16-13-5-11-9-3-8(6-14-7-9)10(11)4-12(13)15-1/h1-2,4-5,8-9,14H,3,6-7H2 | PDB
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| 3.54E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha1 beta gamma delta of electroplax |
J Med Chem 48: 3474-7 (2005)
Article DOI: 10.1021/jm050069n
BindingDB Entry DOI: 10.7270/Q2N87BJ7 |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50475689
(4,4''-Dimethylcaracurinium V Dichloride | Dimethyl...)Show SMILES [Cl-].[Cl-].[H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])N6c7ccccc7[C@@]78CC[N+]9(C)CC%10=CCO[C@@]([H])(N%11c%12ccccc%12[C@@]1(CC[N+]2(C)C4)[C@]%11([H])[C@@]35[H])[C@@]([H])([C@]67[H])[C@@]%10([H])C[C@@]89[H] |r,c:5,t:25| Show InChI InChI=1S/C40H46N4O2.2ClH/c1-43-15-13-39-27-7-3-5-9-29(27)41-35(39)33-25(19-31(39)43)23(21-43)11-17-45-37(33)42-30-10-6-4-8-28(30)40-14-16-44(2)22-24-12-18-46-38(41)34(36(40)42)26(24)20-32(40)44;;/h3-12,25-26,31-38H,13-22H2,1-2H3;2*1H/q+2;;/p-2/t25-,26-,31-,32-,33+,34+,35-,36-,37+,38+,39+,40+,43?,44?;;/m0../s1 | PDB
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| PC cid
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| 5.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of W£rzburg
Curated by ChEMBL
| Assay Description
Displacement of (+/-)-[3H]epibatidine from muscle type nAChR of Torpedo californica in hepes buffer |
Bioorg Med Chem Lett 16: 1481-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.030
BindingDB Entry DOI: 10.7270/Q2D50QQ5 |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Homo sapiens (Human)) | BDBM82070
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1 | PDB
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| 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
In vitro Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 was determined |
Bioorg Med Chem Lett 11: 319-21 (2001)
BindingDB Entry DOI: 10.7270/Q2028S36 |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM82070
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1 | PDB
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| 6.27E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha1 beta gamma delta of electroplax |
J Med Chem 48: 3474-7 (2005)
Article DOI: 10.1021/jm050069n
BindingDB Entry DOI: 10.7270/Q2N87BJ7 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM82070
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1 | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding potency for Nicotinic acetylcholine receptor alpha4-beta2 (rat brain) |
J Med Chem 40: 4169-94 (1998)
Article DOI: 10.1021/jm970377o
BindingDB Entry DOI: 10.7270/Q2QF8TH9 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Show InChI InChI=1S/C9H14N2O/c1-7-6-9(12-10-7)8-4-3-5-11(8)2/h6,8H,3-5H2,1-2H3/t8-/m0/s1 | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Affinity for Nicotinic acetylcholine receptor alpha4-beta2 in rat brain |
J Med Chem 40: 4169-94 (1998)
Article DOI: 10.1021/jm970377o
BindingDB Entry DOI: 10.7270/Q2QF8TH9 |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50220060
((14-dimethylaminomethyl-6H,13H-pyrazino[1,2-a;4,5-...)Show SMILES CN(C)Cc1c2Cn3c(Cn2c2ccccc12)c(CN(C)C)c1ccccc31 Show InChI InChI=1S/C24H28N4/c1-25(2)13-19-17-9-5-7-11-21(17)27-16-24-20(14-26(3)4)18-10-6-8-12-22(18)28(24)15-23(19)27/h5-12H,13-16H2,1-4H3 | PDB
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| 1.07E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of W£rzburg
Curated by ChEMBL
| Assay Description
Displacement of (+/-)-[3H]epibatidine from muscle type nAChR of Torpedo californica in hepes buffer |
Bioorg Med Chem Lett 16: 1481-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.030
BindingDB Entry DOI: 10.7270/Q2D50QQ5 |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Homo sapiens (Human)) | BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)Show SMILES CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)c1c[nH]c2ccccc12 |r,THB:9:7:4.3:1| Show InChI InChI=1S/C17H20N2O2/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16/h2-5,10-13,18H,6-9H2,1H3/t11-,12+,13+ | PDB
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| 2.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
In vitro Binding affinity towards alpha-1-beta-1-gamma delta nAChR was determined |
Bioorg Med Chem Lett 11: 319-21 (2001)
BindingDB Entry DOI: 10.7270/Q2028S36 |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50038415
((2,3-Dihydroxy-benzyl)-trimethyl-ammonium; bromide...)Show InChI InChI=1S/C10H15NO2/c1-11(2,3)7-8-5-4-6-9(12)10(8)13/h4-6H,7H2,1-3H3,(H-,12,13)/p+1 | PDB
Reactome pathway
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| 2.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toledo
Curated by ChEMBL
| Assay Description
Binding affinity against nicotinic acetylcholine receptor (nAChR) |
J Med Chem 37: 4417-20 (1995)
Checked by Author
BindingDB Entry DOI: 10.7270/Q24F1PS9 |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50089157
((3R,5S,7aR)-3-Heptyl-5-methyl-hexahydro-pyrrolizin...)Show InChI InChI=1S/C15H29N/c1-3-4-5-6-7-8-14-11-12-15-10-9-13(2)16(14)15/h13-15H,3-12H2,1-2H3/t13-,14+,15+/m0/s1 | PDB
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| 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Toyama Medical and Pharmaceutical University
Curated by ChEMBL
| Assay Description
Compound was evaluated for inhibition of [3H]-TCP binding to Nicotinic acetylcholine receptor of Torpedo californica |
Bioorg Med Chem Lett 10: 1293-5 (2000)
BindingDB Entry DOI: 10.7270/Q2JH3KCV |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50025037
(CHEBI:3382 | Caracurine V)Show SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])N6c7ccccc7[C@@]78CCN9CC%10=CCO[C@@]([H])(N%11c%12ccccc%12[C@@]1(CCN2C4)[C@]%11([H])[C@@]35[H])[C@@]([H])([C@]67[H])[C@@]%10([H])C[C@@]89[H] |r,c:5,t:24| Show InChI InChI=1S/C38H40N4O2/c1-3-7-27-25(5-1)37-11-13-39-19-21-10-16-44-36-31(23(21)17-29(37)39)33(37)41(27)35-32-24-18-30-38(12-14-40(30)20-22(24)9-15-43-35)26-6-2-4-8-28(26)42(36)34(32)38/h1-10,23-24,29-36H,11-20H2/t23-,24-,29-,30-,31+,32+,33-,34-,35+,36+,37+,38+/m0/s1 | PDB
Reactome pathway
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| <1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of W£rzburg
Curated by ChEMBL
| Assay Description
Displacement of (+/-)-[3H]epibatidine from muscle type nAChR of Torpedo californica in hepes buffer |
Bioorg Med Chem Lett 16: 1481-5 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.030
BindingDB Entry DOI: 10.7270/Q2D50QQ5 |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50089159
((3R,5S)-3,5-Dibutyl-octahydro-indolizine | CHEMBL2...)Show InChI InChI=1S/C16H31N/c1-3-5-8-14-10-7-11-16-13-12-15(17(14)16)9-6-4-2/h14-16H,3-13H2,1-2H3/t14-,15+,16?/m0/s1 | PDB
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| 3.70E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Toyama Medical and Pharmaceutical University
Curated by ChEMBL
| Assay Description
Compound was evaluated for inhibition of [3H]-TCP binding to Nicotinic acetylcholine receptor of Torpedo californica |
Bioorg Med Chem Lett 10: 1293-5 (2000)
BindingDB Entry DOI: 10.7270/Q2JH3KCV |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50089158
((3R,5R)-3,5-Dibutyl-octahydro-indolizine | CHEMBL2...)Show InChI InChI=1S/C16H31N/c1-3-5-8-14-10-7-11-16-13-12-15(17(14)16)9-6-4-2/h14-16H,3-13H2,1-2H3/t14-,15-,16?/m1/s1 | PDB
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| 4.20E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Toyama Medical and Pharmaceutical University
Curated by ChEMBL
| Assay Description
Compound was evaluated for inhibition of [3H]-TCP binding to Nicotinic acetylcholine receptor of Torpedo californica |
Bioorg Med Chem Lett 10: 1293-5 (2000)
BindingDB Entry DOI: 10.7270/Q2JH3KCV |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50089162
(7-((3R,5S,7aR)-5-Propyl-hexahydro-pyrrolizin-3-yl)...)Show InChI InChI=1S/C17H31NO/c1-3-7-15-10-12-17-13-11-16(18(15)17)9-6-4-5-8-14(2)19/h15-17H,3-13H2,1-2H3/t15-,16+,17+/m0/s1 | PDB
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| 8.30E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Toyama Medical and Pharmaceutical University
Curated by ChEMBL
| Assay Description
Compound was evaluated for inhibition of [3H]-TCP binding to Nicotinic acetylcholine receptor of Torpedo californica |
Bioorg Med Chem Lett 10: 1293-5 (2000)
BindingDB Entry DOI: 10.7270/Q2JH3KCV |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50089163
((R)-7-((3R,5S,7aR)-5-Propyl-hexahydro-pyrrolizin-3...)Show SMILES CCC[C@H]1CC[C@@H]2CC[C@@H](CCCCC[C@@H](C)O)N12 Show InChI InChI=1S/C17H33NO/c1-3-7-15-10-12-17-13-11-16(18(15)17)9-6-4-5-8-14(2)19/h14-17,19H,3-13H2,1-2H3/t14-,15+,16-,17-/m1/s1 | PDB
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| 3.10E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Toyama Medical and Pharmaceutical University
Curated by ChEMBL
| Assay Description
Compound was evaluated for inhibition of [3H]-TCP binding to Nicotinic acetylcholine receptor of Torpedo californica |
Bioorg Med Chem Lett 10: 1293-5 (2000)
BindingDB Entry DOI: 10.7270/Q2JH3KCV |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50089164
((S)-7-((3R,5S,7aR)-5-Propyl-hexahydro-pyrrolizin-3...)Show SMILES CCC[C@H]1CC[C@@H]2CC[C@@H](CCCCC[C@H](C)O)N12 Show InChI InChI=1S/C17H33NO/c1-3-7-15-10-12-17-13-11-16(18(15)17)9-6-4-5-8-14(2)19/h14-17,19H,3-13H2,1-2H3/t14-,15-,16+,17+/m0/s1 | PDB
Reactome pathway
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| 3.10E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Toyama Medical and Pharmaceutical University
Curated by ChEMBL
| Assay Description
Compound was evaluated for inhibition of [3H]-TCP binding to Nicotinic acetylcholine receptor of Torpedo californica |
Bioorg Med Chem Lett 10: 1293-5 (2000)
BindingDB Entry DOI: 10.7270/Q2JH3KCV |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50089160
((S)-7-((3R,5S,7aR)-5-Methyl-hexahydro-pyrrolizin-3...)Show InChI InChI=1S/C15H29NO/c1-12-8-9-15-11-10-14(16(12)15)7-5-3-4-6-13(2)17/h12-15,17H,3-11H2,1-2H3/t12-,13-,14+,15+/m0/s1 | PDB
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| 3.30E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Toyama Medical and Pharmaceutical University
Curated by ChEMBL
| Assay Description
Compound was evaluated for inhibition of [3H]-TCP binding to Nicotinic acetylcholine receptor of Torpedo californica |
Bioorg Med Chem Lett 10: 1293-5 (2000)
BindingDB Entry DOI: 10.7270/Q2JH3KCV |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50089161
((R)-7-((3R,5S,7aR)-5-Methyl-hexahydro-pyrrolizin-3...)Show SMILES C[C@@H](O)CCCCC[C@@H]1CC[C@H]2CC[C@H](C)N12 Show InChI InChI=1S/C15H29NO/c1-12-8-9-15-11-10-14(16(12)15)7-5-3-4-6-13(2)17/h12-15,17H,3-11H2,1-2H3/t12-,13+,14+,15+/m0/s1 | PDB
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| 8.30E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Toyama Medical and Pharmaceutical University
Curated by ChEMBL
| Assay Description
Compound was evaluated for inhibition of [3H]-TCP binding to Nicotinic acetylcholine receptor of Torpedo californica |
Bioorg Med Chem Lett 10: 1293-5 (2000)
BindingDB Entry DOI: 10.7270/Q2JH3KCV |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50023331
((+)-pyrido[3,4-b]homotropane | (+/-)-pyrido[3,4-b]...)Show InChI InChI=1S/C11H14N2/c1-2-9-3-4-11(13-9)10-7-12-6-5-8(1)10/h5-7,9,11,13H,1-4H2 | PDB
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| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Stauffer Chemical Company
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-MCC binding to torpedo electroplax membranes |
J Med Chem 31: 506-9 (1988)
BindingDB Entry DOI: 10.7270/Q2B27T8K |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50023330
(1-(9-Aza-bicyclo[4.2.1]non-2-en-2-yl)-ethanone | 1...)Show InChI InChI=1S/C10H15NO/c1-7(12)9-4-2-3-8-5-6-10(9)11-8/h4,8,10-11H,2-3,5-6H2,1H3 | PDB
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| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Stauffer Chemical Company
Curated by ChEMBL
| Assay Description
Inhibition of (-)-[3H]-nicotine binding to rat brain membranes |
J Med Chem 31: 506-9 (1988)
BindingDB Entry DOI: 10.7270/Q2B27T8K |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50023330
(1-(9-Aza-bicyclo[4.2.1]non-2-en-2-yl)-ethanone | 1...)Show InChI InChI=1S/C10H15NO/c1-7(12)9-4-2-3-8-5-6-10(9)11-8/h4,8,10-11H,2-3,5-6H2,1H3 | PDB
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Stauffer Chemical Company
Curated by ChEMBL
| Assay Description
inhibition of (-)-[3H]-nicotine binding to torpedo electroplax membranes |
J Med Chem 31: 506-9 (1988)
BindingDB Entry DOI: 10.7270/Q2B27T8K |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50023331
((+)-pyrido[3,4-b]homotropane | (+/-)-pyrido[3,4-b]...)Show InChI InChI=1S/C11H14N2/c1-2-9-3-4-11(13-9)10-7-12-6-5-8(1)10/h5-7,9,11,13H,1-4H2 | PDB
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Stauffer Chemical Company
Curated by ChEMBL
| Assay Description
inhibition of (-)-[3H]-nicotine binding to torpedo electroplax membranes |
J Med Chem 31: 506-9 (1988)
BindingDB Entry DOI: 10.7270/Q2B27T8K |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM82070
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1 | PDB
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Stauffer Chemical Company
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-MCC binding to rat brain membranes |
J Med Chem 31: 506-9 (1988)
BindingDB Entry DOI: 10.7270/Q2B27T8K |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM82070
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1 | PDB
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| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Stauffer Chemical Company
Curated by ChEMBL
| Assay Description
Inhibition of (-)-[3H]-nicotine binding to rat brain membranes |
J Med Chem 31: 506-9 (1988)
BindingDB Entry DOI: 10.7270/Q2B27T8K |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Rattus norvegicus-RAT) | BDBM50547500
(CHEMBL4759352)Show SMILES [H][C@@]12CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3c[nH]cn3)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@@H](N)CC(N)=O)C(=O)N1)NC(=O)[C@H](C)NC2=O)C(N)=O |r| | PDB
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| n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of rat (alpha1)2betagammadelta expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced channel current respons... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00957
BindingDB Entry DOI: 10.7270/Q27S7SCT |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50023328
(3-Pyrrolidin-2-yl-pyridine | CHEMBL1132 | Nornicot...)Show InChI InChI=1S/C9H12N2/c1-3-8(7-10-5-1)9-4-2-6-11-9/h1,3,5,7,9,11H,2,4,6H2 | PDB
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| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Stauffer Chemical Company
Curated by ChEMBL
| Assay Description
inhibition of (-)-[3H]-nicotine binding to torpedo electroplax membranes |
J Med Chem 31: 506-9 (1988)
BindingDB Entry DOI: 10.7270/Q2B27T8K |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50023328
(3-Pyrrolidin-2-yl-pyridine | CHEMBL1132 | Nornicot...)Show InChI InChI=1S/C9H12N2/c1-3-8(7-10-5-1)9-4-2-6-11-9/h1,3,5,7,9,11H,2,4,6H2 | PDB
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| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Stauffer Chemical Company
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-MCC binding to rat brain membranes |
J Med Chem 31: 506-9 (1988)
BindingDB Entry DOI: 10.7270/Q2B27T8K |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50023327
(3-Methyl-4,13-diaza-tricyclo[8.2.1.0*2,7*]trideca-...)Show InChI InChI=1S/C12H16N2/c1-8-12-9(6-7-13-8)2-3-10-4-5-11(12)14-10/h6-7,10-11,14H,2-5H2,1H3 | PDB
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| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Stauffer Chemical Company
Curated by ChEMBL
| Assay Description
Inhibition of (-)-[3H]-nicotine binding to rat brain membranes |
J Med Chem 31: 506-9 (1988)
BindingDB Entry DOI: 10.7270/Q2B27T8K |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50023327
(3-Methyl-4,13-diaza-tricyclo[8.2.1.0*2,7*]trideca-...)Show InChI InChI=1S/C12H16N2/c1-8-12-9(6-7-13-8)2-3-10-4-5-11(12)14-10/h6-7,10-11,14H,2-5H2,1H3 | PDB
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| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Stauffer Chemical Company
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-MCC binding to rat brain membranes |
J Med Chem 31: 506-9 (1988)
BindingDB Entry DOI: 10.7270/Q2B27T8K |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Homo sapiens (Human)) | BDBM50094299
(CHEMBL15998 | N-[(S)-1-(12-Amino-dodecylcarbamoyl)...)Show SMILES CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCCCCCCCN Show InChI InChI=1S/C25H43N3O3/c1-2-13-24(30)28-23(20-21-14-16-22(29)17-15-21)25(31)27-19-12-10-8-6-4-3-5-7-9-11-18-26/h14-17,23,29H,2-13,18-20,26H2,1H3,(H,27,31)(H,28,30)/t23-/m0/s1 | PDB
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 790 | n/a | n/a | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description
Antagonist activity at human muscle-type nAChR (embryonic muscle) expressed in TE671 cells; (end value). |
J Med Chem 43: 4526-33 (2000)
Article DOI: 10.1021/jm000220n
BindingDB Entry DOI: 10.7270/Q2F192F2 |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50023329
(13-Methyl-4,13-diaza-tricyclo[8.2.1.0*2,7*]trideca...)Show InChI InChI=1S/C12H16N2/c1-14-10-3-2-9-6-7-13-8-11(9)12(14)5-4-10/h6-8,10,12H,2-5H2,1H3 | PDB
Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
Similars
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| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Stauffer Chemical Company
Curated by ChEMBL
| Assay Description
Inhibition of (-)-[3H]-nicotine binding to rat brain membranes |
J Med Chem 31: 506-9 (1988)
BindingDB Entry DOI: 10.7270/Q2B27T8K |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50023329
(13-Methyl-4,13-diaza-tricyclo[8.2.1.0*2,7*]trideca...)Show InChI InChI=1S/C12H16N2/c1-14-10-3-2-9-6-7-13-8-11(9)12(14)5-4-10/h6-8,10,12H,2-5H2,1H3 | PDB
Reactome pathway
KEGG
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B.MOAD
DrugBank
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Stauffer Chemical Company
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-MCC binding to rat brain membranes |
J Med Chem 31: 506-9 (1988)
BindingDB Entry DOI: 10.7270/Q2B27T8K |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Homo sapiens (Human)) | BDBM50473035
(CHEMBL342483)Show SMILES CCCC(=O)N[C@@H](Cc1cccc(O)c1)C(=O)NCCCCCCCCCCCCN Show InChI InChI=1S/C25H43N3O3/c1-2-14-24(30)28-23(20-21-15-13-16-22(29)19-21)25(31)27-18-12-10-8-6-4-3-5-7-9-11-17-26/h13,15-16,19,23,29H,2-12,14,17-18,20,26H2,1H3,(H,27,31)(H,28,30)/t23-/m0/s1 | PDB
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| PC cid
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UniChem
| Article
PubMed
| n/a | n/a | 2.43E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description
Antagonist activity at human muscle-type nAChR (embryonic muscle) expressed in TE671 cells; (end value). |
J Med Chem 43: 4526-33 (2000)
Article DOI: 10.1021/jm000220n
BindingDB Entry DOI: 10.7270/Q2F192F2 |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Homo sapiens (Human)) | BDBM50473033
(CHEMBL342258)Show SMILES NCCCOCCCCOCCCNC(=O)[C@H](Cc1cccc(O)c1)NC(=O)CC1CCCCC1 Show InChI InChI=1S/C27H45N3O5/c28-13-7-17-34-15-4-5-16-35-18-8-14-29-27(33)25(20-23-11-6-12-24(31)19-23)30-26(32)21-22-9-2-1-3-10-22/h6,11-12,19,22,25,31H,1-5,7-10,13-18,20-21,28H2,(H,29,33)(H,30,32)/t25-/m0/s1 | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.47E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description
Antagonist activity at human muscle-type nAChR (embryonic muscle) expressed in TE671 cells; (end value). |
J Med Chem 43: 4526-33 (2000)
Article DOI: 10.1021/jm000220n
BindingDB Entry DOI: 10.7270/Q2F192F2 |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Homo sapiens (Human)) | BDBM50473023
(CHEMBL342235)Show SMILES NCCCNCCCCNCCCNC(=O)[C@H](Cc1cccc(O)c1)NC(=O)CC1CCCCC1 Show InChI InChI=1S/C27H47N5O3/c28-13-7-16-29-14-4-5-15-30-17-8-18-31-27(35)25(20-23-11-6-12-24(33)19-23)32-26(34)21-22-9-2-1-3-10-22/h6,11-12,19,22,25,29-30,33H,1-5,7-10,13-18,20-21,28H2,(H,31,35)(H,32,34)/t25-/m0/s1 | PDB
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antibodypedia
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.33E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description
Antagonist activity at human muscle-type nAChR (embryonic muscle) expressed in TE671 cells; (end value). |
J Med Chem 43: 4526-33 (2000)
Article DOI: 10.1021/jm000220n
BindingDB Entry DOI: 10.7270/Q2F192F2 |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Homo sapiens (Human)) | BDBM50473029
(CHEMBL140056)Show SMILES NCCCOCCCCOCCCNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CC1CCCCC1 Show InChI InChI=1S/C27H45N3O5/c28-14-6-18-34-16-4-5-17-35-19-7-15-29-27(33)25(20-23-10-12-24(31)13-11-23)30-26(32)21-22-8-2-1-3-9-22/h10-13,22,25,31H,1-9,14-21,28H2,(H,29,33)(H,30,32)/t25-/m0/s1 | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.69E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description
Antagonist activity at human muscle-type nAChR (embryonic muscle) expressed in TE671 cells; (end value). |
J Med Chem 43: 4526-33 (2000)
Article DOI: 10.1021/jm000220n
BindingDB Entry DOI: 10.7270/Q2F192F2 |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Homo sapiens (Human)) | BDBM50322520
((2S,3S)-2-Biphenyl-4-yl-3,5,5-trimethylmorpholin-2...)Show SMILES C[C@@H]1NC(C)(C)CO[C@@]1(O)c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C19H23NO2/c1-14-19(21,22-13-18(2,3)20-14)17-11-9-16(10-12-17)15-7-5-4-6-8-15/h4-12,14,20-21H,13H2,1-3H3/t14-,19+/m0/s1 | PDB
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| Article
PubMed
| n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Barrow Neurological Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at alpha-1-beta-1-gamma-delta nicotinic receptor in human TE671 cells assessed as inhibition varbamylcholine-induced radiolabeled... |
J Med Chem 53: 4731-48 (2010)
Article DOI: 10.1021/jm1003232
BindingDB Entry DOI: 10.7270/Q2CF9Q9N |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Homo sapiens (Human)) | BDBM50322515
((2S,3S)-2-(Naphthalen-1-yl)-3,5,5-trimethylmorphol...)Show SMILES C[C@@H]1NC(C)(C)CO[C@@]1(O)c1cccc(c1)-c1cccc2ccccc12 |r| Show InChI InChI=1S/C23H25NO2/c1-16-23(25,26-15-22(2,3)24-16)19-11-6-10-18(14-19)21-13-7-9-17-8-4-5-12-20(17)21/h4-14,16,24-25H,15H2,1-3H3/t16-,23+/m0/s1 | PDB
KEGG
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| CHEMBL
PC cid
PC sid
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Similars
| Article
PubMed
| n/a | n/a | 6.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Barrow Neurological Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at alpha-1-beta-1-gamma-delta nicotinic receptor in human TE671 cells assessed as inhibition varbamylcholine-induced radiolabeled... |
J Med Chem 53: 4731-48 (2010)
Article DOI: 10.1021/jm1003232
BindingDB Entry DOI: 10.7270/Q2CF9Q9N |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Homo sapiens (Human)) | BDBM50322518
((+/-)2-(3,4-Dichlorophenyl)-3,5,5-trimethylmorphol...)Show InChI InChI=1S/C13H17Cl2NO2/c1-8-13(17,18-7-12(2,3)16-8)9-4-5-10(14)11(15)6-9/h4-6,8,16-17H,7H2,1-3H3 | PDB
KEGG
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Barrow Neurological Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at alpha-1-beta-1-gamma-delta nicotinic receptor in human TE671 cells assessed as inhibition varbamylcholine-induced radiolabeled... |
J Med Chem 53: 4731-48 (2010)
Article DOI: 10.1021/jm1003232
BindingDB Entry DOI: 10.7270/Q2CF9Q9N |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Homo sapiens (Human)) | BDBM50322516
((+/-)2-(3,5-Dichlorophenyl)-3,5,5-trimethylmorphol...)Show InChI InChI=1S/C13H17Cl2NO2/c1-8-13(17,18-7-12(2,3)16-8)9-4-10(14)6-11(15)5-9/h4-6,8,16-17H,7H2,1-3H3 | PDB
KEGG
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antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Barrow Neurological Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at alpha-1-beta-1-gamma-delta nicotinic receptor in human TE671 cells assessed as inhibition varbamylcholine-induced radiolabeled... |
J Med Chem 53: 4731-48 (2010)
Article DOI: 10.1021/jm1003232
BindingDB Entry DOI: 10.7270/Q2CF9Q9N |
More data for this
Ligand-Target Pair | |
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