Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metabotropic glutamate receptor 1/2/3/4/5/6/7/8 (Rattus norvegicus-Rattus norvegicus (Rat)-RAT) | BDBM100152 (7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Binding affinity for rat 5-hydroxytryptamine 2A receptor using [3H]-DOB | Bioorg Med Chem Lett 13: 4421-5 (2003) BindingDB Entry DOI: 10.7270/Q2D21X2G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1/2/3/4/5/6/7/8 (Rattus norvegicus-Rattus norvegicus (Rat)-RAT) | BDBM50132104 (6-Methoxy-1-methyl-4,9-dihydro-3H-beta-carboline |...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Binding affinity towards Alpha-2B adrenergic receptor | Bioorg Med Chem Lett 13: 4421-5 (2003) BindingDB Entry DOI: 10.7270/Q2D21X2G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1/2/3/4/5/6/7/8 (Rattus norvegicus-Rattus norvegicus (Rat)-RAT) | BDBM50136493 (1-Methyl-4,9-dihydro-3H-beta-carboline | 1-methyl-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Binding affinity towards Alpha-2B adrenergic receptor | Bioorg Med Chem Lett 13: 4421-5 (2003) BindingDB Entry DOI: 10.7270/Q2D21X2G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (Mus musculus) | BDBM50333367 (6-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-tria...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description Binding affinity to mouse mGluR1 | Bioorg Med Chem 19: 102-10 (2011) Article DOI: 10.1016/j.bmc.2010.11.048 BindingDB Entry DOI: 10.7270/Q21R6QSS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (Mus musculus) | BDBM50273899 (CHEMBL456823 | tert-Butyl-4-[1-(2-fuluoropyridine-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay | Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (Mus musculus) | BDBM50273942 (4-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-tria...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay | Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (Mus musculus) | BDBM50273941 (CHEMBL456196 | iso-Propyl-4-[1-(2-fuluoropyridine-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay | Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (Mus musculus) | BDBM50273898 (CHEMBL452618 | tert-Butyl-4-[1-(2-fuluoropyridine-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay | Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (Mus musculus) | BDBM50273829 (CHEMBL461673 | tert-Butyl-4-[1-(2-fluorophenyl)-1H...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay | Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (Mus musculus) | BDBM50273828 (CHEMBL511355 | tert-Butyl-4-(1-phenyl-1H-1,2,3-tri...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay | Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (Mus musculus) | BDBM50273863 (CHEMBL460827 | tert-Butyl-4-[1-(4-fuluorophenyl)-1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay | Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (Mus musculus) | BDBM50273830 (CHEMBL460391 | tert-Butyl-4-[1-(3-fuluorophenyl)-1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay | Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (Mus musculus) | BDBM50273864 (CHEMBL511352 | tert-Butyl-4-[1-(2-methylphenyl)-1H...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay | Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (Mus musculus) | BDBM50273895 (CHEMBL457872 | tert-Butyl-4-[1-pyridin-2-yl-1H-1,2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay | Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (Mus musculus) | BDBM50273867 (1-(3,3-Dimethylbutanolyl)-4-[1-(2-fluorophenyl)-1H...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay | Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (Mus musculus) | BDBM50273896 (CHEMBL453249 | tert-Butyl-4-[1-pyridin-3-yl-1 H-1,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay | Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (Mus musculus) | BDBM50273940 (CHEMBL457026 | iso-Propyl-4-[1-(2-fuluoropyridine-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay | Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (Mus musculus) | BDBM50273866 (CHEMBL461034 | N-(tert-Butyl)-4-[1-(2-fluorophenyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay | Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (Mus musculus) | BDBM50273897 (CHEMBL457873 | tert-Butyl-4-[1-pyridin-4-yl-1 H-1,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay | Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (Mus musculus) | BDBM50273865 (CHEMBL461033 | tert-Butyl-4-[1-(2-methoxylphenyl)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute Curated by ChEMBL | Assay Description Antagonist activity at mouse mGluR1 expressed in CHO cells assessed as calcium flux by FLIPR assay | Bioorg Med Chem 16: 9817-29 (2008) Article DOI: 10.1016/j.bmc.2008.09.060 BindingDB Entry DOI: 10.7270/Q2QN66K2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1/2/3/4/5/6/7/8 (Rattus norvegicus-Rattus norvegicus (Rat)-RAT) | BDBM50079183 ((2S)-amino(3,5-dihydroxyphenyl)ethanoic acid | (S)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | n/a | n/a | n/a | n/a | 1.09E+4 | n/a | n/a | n/a | n/a | |
TBA | Assay Description Compound was tested for ability to stimulate metabotropic glutamate receptor (mGluR) mediated phosphoinositide hydrolysis in rat hippocampus | Citation and Details BindingDB Entry DOI: 10.7270/Q20K2BQS | |||||||||||
More data for this Ligand-Target Pair |