Found 198 hits Enz. Inhib. hit(s) with Target = 'Replication protein A 70 kDa DNA-binding subunit' AND taxid = 9606 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM461292
(US10774063, Compound NG-01-24)Show SMILES COc1ccc2cc(C3CC(=NN3C(=O)CCCC(O)=O)c3ccc(I)cc3)c(Cl)nc2c1 |c:10| Show InChI InChI=1S/C24H21ClIN3O4/c1-33-17-10-7-15-11-18(24(25)27-19(15)12-17)21-13-20(14-5-8-16(26)9-6-14)28-29(21)22(30)3-2-4-23(31)32/h5-12,21H,2-4,13H2,1H3,(H,31,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation
US Patent
| |
US Patent US10774063 (2020)
BindingDB Entry DOI: 10.7270/Q21N8479 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM461287
(US10774063, Compound NG-01-25 | US10774063, Compou...)Show SMILES CCOc1ccc2cc(C3CC(=NN3C(=O)CCCCC(O)=O)c3ccc(I)cc3)c(Cl)nc2c1 |c:11| Show InChI InChI=1S/C26H25ClIN3O4/c1-2-35-19-12-9-17-13-20(26(27)29-21(17)14-19)23-15-22(16-7-10-18(28)11-8-16)30-31(23)24(32)5-3-4-6-25(33)34/h7-14,23H,2-6,15H2,1H3,(H,33,34) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation
US Patent
| |
US Patent US10774063 (2020)
BindingDB Entry DOI: 10.7270/Q21N8479 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM260646
(US9533969, TDRL-505)Show SMILES CCOc1ccc2cc(C3CC(=NN3C(=O)CCC(O)=O)c3ccc(Br)cc3)c(Cl)nc2c1 |c:11| Show InChI InChI=1S/C24H21BrClN3O4/c1-2-33-17-8-5-15-11-18(24(26)27-19(15)12-17)21-13-20(14-3-6-16(25)7-4-14)28-29(21)22(30)9-10-23(31)32/h3-8,11-12,21H,2,9-10,13H2,1H3,(H,31,32) | PDB
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antibodypedia
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PC sid
UniChem
| US Patent
| n/a | n/a | 1.29E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation
US Patent
| Assay Description
Small molecule inhibitors were obtained from ChemDiv and resuspended in DMSO. Compound TDLR-505 was independently synthesized and structure confirmed... |
US Patent US9533969 (2017)
BindingDB Entry DOI: 10.7270/Q2445KDJ |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM461289
(US10774063, Compound TDRL-652)Show SMILES CCOc1ccc2cc(C3CC(=NN3C(=O)CCCCC(O)=O)c3cccc(I)c3)c(Cl)nc2c1 |c:11| Show InChI InChI=1S/C26H25ClIN3O4/c1-2-35-19-11-10-17-13-20(26(27)29-21(17)14-19)23-15-22(16-6-5-7-18(28)12-16)30-31(23)24(32)8-3-4-9-25(33)34/h5-7,10-14,23H,2-4,8-9,15H2,1H3,(H,33,34) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation
US Patent
| |
US Patent US10774063 (2020)
BindingDB Entry DOI: 10.7270/Q21N8479 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM461287
(US10774063, Compound NG-01-25 | US10774063, Compou...)Show SMILES CCOc1ccc2cc(C3CC(=NN3C(=O)CCCCC(O)=O)c3ccc(I)cc3)c(Cl)nc2c1 |c:11| Show InChI InChI=1S/C26H25ClIN3O4/c1-2-35-19-12-9-17-13-20(26(27)29-21(17)14-19)23-15-22(16-7-10-18(28)11-8-16)30-31(23)24(32)5-3-4-6-25(33)34/h7-14,23H,2-6,15H2,1H3,(H,33,34) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation
US Patent
| |
US Patent US10774063 (2020)
BindingDB Entry DOI: 10.7270/Q21N8479 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM61188
(4-[5-(4-methylphenyl)-3-[3-(4-methylphenyl)-1-phen...)Show SMILES Cc1ccc(cc1)C1=NN(C(C1)c1cn(nc1-c1ccc(C)cc1)-c1ccccc1)C(=O)CCC(O)=O |t:8| Show InChI InChI=1S/C30H28N4O3/c1-20-8-12-22(13-9-20)26-18-27(34(31-26)28(35)16-17-29(36)37)25-19-33(24-6-4-3-5-7-24)32-30(25)23-14-10-21(2)11-15-23/h3-15,19,27H,16-18H2,1-2H3,(H,36,37) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.03E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation
US Patent
| Assay Description
Small molecule inhibitors were obtained from ChemDiv and resuspended in DMSO. Compound TDLR-505 was independently synthesized and structure confirmed... |
US Patent US9533969 (2017)
BindingDB Entry DOI: 10.7270/Q2445KDJ |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM461282
(US10774063, Compound TDRL-543)Show SMILES CCOc1ccc2cc(C3CC(=NN3C(=O)CCCCC(O)=O)c3ccc(Br)cc3)c(Cl)nc2c1 |c:11| Show InChI InChI=1S/C26H25BrClN3O4/c1-2-35-19-12-9-17-13-20(26(28)29-21(17)14-19)23-15-22(16-7-10-18(27)11-8-16)30-31(23)24(32)5-3-4-6-25(33)34/h7-14,23H,2-6,15H2,1H3,(H,33,34) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation
US Patent
| |
US Patent US10774063 (2020)
BindingDB Entry DOI: 10.7270/Q21N8479 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM461270
(US10774063, Compound TDRL-505 | US10774063, Compou...)Show SMILES CCOc1ccc2cc(C3CC(=NN3C(=O)CCCC(O)=O)c3ccc(Br)cc3)c(Cl)nc2c1 |c:11| Show InChI InChI=1S/C25H23BrClN3O4/c1-2-34-18-11-8-16-12-19(25(27)28-20(16)13-18)22-14-21(15-6-9-17(26)10-7-15)29-30(22)23(31)4-3-5-24(32)33/h6-13,22H,2-5,14H2,1H3,(H,32,33) | PDB
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PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation
US Patent
| Assay Description
EMSA reactions (20 μL) were performed with 50 nM fl-RPA and 2.5 nM 5′[32P]-labeled 34-base DNA in buffer containing 20 mM HEPES (pH 7.0), ... |
US Patent US10774063 (2020)
BindingDB Entry DOI: 10.7270/Q21N8479 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM461288
(US10774063, Compound TDRL-557)Show SMILES CCOc1ccc2cc(C3CC(=NN3C(=O)CCCCC(O)=O)c3ccc(OC(F)(F)F)cc3)c(Cl)nc2c1 |c:11| Show InChI InChI=1S/C27H25ClF3N3O5/c1-2-38-19-12-9-17-13-20(26(28)32-21(17)14-19)23-15-22(16-7-10-18(11-8-16)39-27(29,30)31)33-34(23)24(35)5-3-4-6-25(36)37/h7-14,23H,2-6,15H2,1H3,(H,36,37) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation
US Patent
| |
US Patent US10774063 (2020)
BindingDB Entry DOI: 10.7270/Q21N8479 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM461285
(US10774063, Compound TDRL-534)Show SMILES COc1ccc2cc(C3CC(=NN3C(=O)CCCCC(O)=O)c3ccc(Br)cc3)c(Cl)nc2c1 |c:10| Show InChI InChI=1S/C25H23BrClN3O4/c1-34-18-11-8-16-12-19(25(27)28-20(16)13-18)22-14-21(15-6-9-17(26)10-7-15)29-30(22)23(31)4-2-3-5-24(32)33/h6-13,22H,2-5,14H2,1H3,(H,32,33) | PDB
UniProtKB/SwissProt
antibodypedia
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AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation
US Patent
| |
US Patent US10774063 (2020)
BindingDB Entry DOI: 10.7270/Q21N8479 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM461270
(US10774063, Compound TDRL-505 | US10774063, Compou...)Show SMILES CCOc1ccc2cc(C3CC(=NN3C(=O)CCCC(O)=O)c3ccc(Br)cc3)c(Cl)nc2c1 |c:11| Show InChI InChI=1S/C25H23BrClN3O4/c1-2-34-18-11-8-16-12-19(25(27)28-20(16)13-18)22-14-21(15-6-9-17(26)10-7-15)29-30(22)23(31)4-3-5-24(32)33/h6-13,22H,2-5,14H2,1H3,(H,32,33) | PDB
UniProtKB/SwissProt
antibodypedia
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PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation
US Patent
| |
US Patent US10774063 (2020)
BindingDB Entry DOI: 10.7270/Q21N8479 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM461286
(US10774063, Compound TDRL-556)Show SMILES CC(C)Oc1ccc2cc(C3CC(=NN3C(=O)CCCCC(O)=O)c3ccc(Br)cc3)c(Cl)nc2c1 |c:12| Show InChI InChI=1S/C27H27BrClN3O4/c1-16(2)36-20-12-9-18-13-21(27(29)30-22(18)14-20)24-15-23(17-7-10-19(28)11-8-17)31-32(24)25(33)5-3-4-6-26(34)35/h7-14,16,24H,3-6,15H2,1-2H3,(H,34,35) | PDB
UniProtKB/SwissProt
antibodypedia
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AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 4.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation
US Patent
| |
US Patent US10774063 (2020)
BindingDB Entry DOI: 10.7270/Q21N8479 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM461280
(US10774063, Compound TDRL-533)Show SMILES COc1ccc2cc(C3CC(=NN3C(=O)CCCC(O)=O)c3ccc(Br)cc3)c(Cl)nc2c1 |c:10| Show InChI InChI=1S/C24H21BrClN3O4/c1-33-17-10-7-15-11-18(24(26)27-19(15)12-17)21-13-20(14-5-8-16(25)9-6-14)28-29(21)22(30)3-2-4-23(31)32/h5-12,21H,2-4,13H2,1H3,(H,31,32) | PDB
UniProtKB/SwissProt
antibodypedia
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation
US Patent
| |
US Patent US10774063 (2020)
BindingDB Entry DOI: 10.7270/Q21N8479 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM260649
(US9533969, TDRL-522)Show SMILES Cc1ccc(cc1)-c1nn(cc1C1CC(=NN1C(=O)CCC(O)=O)c1ccc(Br)cc1)-c1ccccc1 |c:16| Show InChI InChI=1S/C29H25BrN4O3/c1-19-7-9-21(10-8-19)29-24(18-33(32-29)23-5-3-2-4-6-23)26-17-25(20-11-13-22(30)14-12-20)31-34(26)27(35)15-16-28(36)37/h2-14,18,26H,15-17H2,1H3,(H,36,37) | PDB
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UniChem
| US Patent
| n/a | n/a | 5.61E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation
US Patent
| Assay Description
Small molecule inhibitors were obtained from ChemDiv and resuspended in DMSO. Compound TDLR-505 was independently synthesized and structure confirmed... |
US Patent US9533969 (2017)
BindingDB Entry DOI: 10.7270/Q2445KDJ |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM461276
(US10774063, Compound j)Show SMILES COc1ccc2cc(C3CC(=NN3C(=O)CCCC(O)=O)c3ccc(Cl)cc3)c(Cl)nc2c1 |c:10| Show InChI InChI=1S/C24H21Cl2N3O4/c1-33-17-10-7-15-11-18(24(26)27-19(15)12-17)21-13-20(14-5-8-16(25)9-6-14)28-29(21)22(30)3-2-4-23(31)32/h5-12,21H,2-4,13H2,1H3,(H,31,32) | PDB
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PC sid
UniChem
| US Patent
| n/a | n/a | 6.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation
US Patent
| Assay Description
EMSA reactions (20 μL) were performed with 50 nM fl-RPA and 2.5 nM 5′[32P]-labeled 34-base DNA in buffer containing 20 mM HEPES (pH 7.0), ... |
US Patent US10774063 (2020)
BindingDB Entry DOI: 10.7270/Q21N8479 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM260648
(US9533969, TDRL-521)Show SMILES COc1ccc(cc1)C1=NN(C(C1)c1cn(nc1-c1ccc(C)cc1)-c1ccccc1)C(=O)CCC(O)=O |t:9| Show InChI InChI=1S/C30H28N4O4/c1-20-8-10-22(11-9-20)30-25(19-33(32-30)23-6-4-3-5-7-23)27-18-26(21-12-14-24(38-2)15-13-21)31-34(27)28(35)16-17-29(36)37/h3-15,19,27H,16-18H2,1-2H3,(H,36,37) | PDB
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| PC cid
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UniChem
| US Patent
| n/a | n/a | 7.17E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation
US Patent
| Assay Description
Small molecule inhibitors were obtained from ChemDiv and resuspended in DMSO. Compound TDLR-505 was independently synthesized and structure confirmed... |
US Patent US9533969 (2017)
BindingDB Entry DOI: 10.7270/Q2445KDJ |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM461272
(US10774063, Compound f)Show SMILES COc1ccc2cc(C3CC(=NN3C(=O)CCC(O)=O)c3ccc(Cl)cc3)c(Cl)nc2c1 |c:10| Show InChI InChI=1S/C23H19Cl2N3O4/c1-32-16-7-4-14-10-17(23(25)26-18(14)11-16)20-12-19(13-2-5-15(24)6-3-13)27-28(20)21(29)8-9-22(30)31/h2-7,10-11,20H,8-9,12H2,1H3,(H,30,31) | PDB
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| US Patent
| n/a | n/a | 7.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation
US Patent
| Assay Description
EMSA reactions (20 μL) were performed with 50 nM fl-RPA and 2.5 nM 5′[32P]-labeled 34-base DNA in buffer containing 20 mM HEPES (pH 7.0), ... |
US Patent US10774063 (2020)
BindingDB Entry DOI: 10.7270/Q21N8479 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM461290
(US10774063, Compound NG-01-02)Show SMILES CCOc1ccc2cc(C3CC(=NN3c3cccc(c3)C(O)=O)c3ccc(I)cc3)c(Cl)nc2c1 |c:11| Show InChI InChI=1S/C27H21ClIN3O3/c1-2-35-21-11-8-17-13-22(26(28)30-23(17)14-21)25-15-24(16-6-9-19(29)10-7-16)31-32(25)20-5-3-4-18(12-20)27(33)34/h3-14,25H,2,15H2,1H3,(H,33,34) | PDB
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| PC cid
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UniChem
| US Patent
| n/a | n/a | 7.55E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation
US Patent
| |
US Patent US10774063 (2020)
BindingDB Entry DOI: 10.7270/Q21N8479 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM461271
(US10774063, Compound e)Show SMILES CCOc1ccc2cc(C3CC(=NN3C(=O)CCC(O)=O)c3ccc(C)cc3)c(Cl)nc2c1 |c:11| Show InChI InChI=1S/C25H24ClN3O4/c1-3-33-18-9-8-17-12-19(25(26)27-20(17)13-18)22-14-21(16-6-4-15(2)5-7-16)28-29(22)23(30)10-11-24(31)32/h4-9,12-13,22H,3,10-11,14H2,1-2H3,(H,31,32) | PDB
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| n/a | n/a | 8.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation
US Patent
| Assay Description
EMSA reactions (20 μL) were performed with 50 nM fl-RPA and 2.5 nM 5′[32P]-labeled 34-base DNA in buffer containing 20 mM HEPES (pH 7.0), ... |
US Patent US10774063 (2020)
BindingDB Entry DOI: 10.7270/Q21N8479 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM461274
(US10774063, Compound h)Show SMILES COc1ccc2cc(C3CC(=NN3C(=O)CCC(O)=O)c3ccc(OC)c(OC)c3)c(Cl)nc2c1 |c:10| Show InChI InChI=1S/C25H24ClN3O6/c1-33-16-6-4-14-10-17(25(26)27-18(14)12-16)20-13-19(28-29(20)23(30)8-9-24(31)32)15-5-7-21(34-2)22(11-15)35-3/h4-7,10-12,20H,8-9,13H2,1-3H3,(H,31,32) | PDB
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation
US Patent
| Assay Description
EMSA reactions (20 μL) were performed with 50 nM fl-RPA and 2.5 nM 5′[32P]-labeled 34-base DNA in buffer containing 20 mM HEPES (pH 7.0), ... |
US Patent US10774063 (2020)
BindingDB Entry DOI: 10.7270/Q21N8479 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM461273
(US10774063, Compound g)Show SMILES COc1ccc(cc1)C1=NN(C(C1)c1cc2ccc(OC)cc2nc1Cl)C(=O)CCC(O)=O |t:9| Show InChI InChI=1S/C24H22ClN3O5/c1-32-16-6-3-14(4-7-16)20-13-21(28(27-20)22(29)9-10-23(30)31)18-11-15-5-8-17(33-2)12-19(15)26-24(18)25/h3-8,11-12,21H,9-10,13H2,1-2H3,(H,30,31) | PDB
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Indiana University Research and Technology Corporation
US Patent
| Assay Description
EMSA reactions (20 μL) were performed with 50 nM fl-RPA and 2.5 nM 5′[32P]-labeled 34-base DNA in buffer containing 20 mM HEPES (pH 7.0), ... |
US Patent US10774063 (2020)
BindingDB Entry DOI: 10.7270/Q21N8479 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM461269
(US10774063, Compound c)Show SMILES COc1ccc(cc1)C1=NN(C(C1)c1ccccc1OC)C(=O)CCCC(O)=O |t:9| Show InChI InChI=1S/C22H24N2O5/c1-28-16-12-10-15(11-13-16)18-14-19(17-6-3-4-7-20(17)29-2)24(23-18)21(25)8-5-9-22(26)27/h3-4,6-7,10-13,19H,5,8-9,14H2,1-2H3,(H,26,27) | PDB
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Indiana University Research and Technology Corporation
US Patent
| Assay Description
EMSA reactions (20 μL) were performed with 50 nM fl-RPA and 2.5 nM 5′[32P]-labeled 34-base DNA in buffer containing 20 mM HEPES (pH 7.0), ... |
US Patent US10774063 (2020)
BindingDB Entry DOI: 10.7270/Q21N8479 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM461259
(US10774063, Compound b)Show SMILES COc1ccc(cc1OC)C1CC(=NN1C(=O)CCCC(O)=O)c1ccc(C)cc1 |c:13| Show InChI InChI=1S/C23H26N2O5/c1-15-7-9-16(10-8-15)18-14-19(17-11-12-20(29-2)21(13-17)30-3)25(24-18)22(26)5-4-6-23(27)28/h7-13,19H,4-6,14H2,1-3H3,(H,27,28) | PDB
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Indiana University Research and Technology Corporation
US Patent
| Assay Description
EMSA reactions (20 μL) were performed with 50 nM fl-RPA and 2.5 nM 5′[32P]-labeled 34-base DNA in buffer containing 20 mM HEPES (pH 7.0), ... |
US Patent US10774063 (2020)
BindingDB Entry DOI: 10.7270/Q21N8479 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM461255
(US10774063, Compound a)Show SMILES COc1ccc(cc1OC)C1CC(=NN1C(=O)CCCC(O)=O)c1ccccc1 |c:13| Show InChI InChI=1S/C22H24N2O5/c1-28-19-12-11-16(13-20(19)29-2)18-14-17(15-7-4-3-5-8-15)23-24(18)21(25)9-6-10-22(26)27/h3-5,7-8,11-13,18H,6,9-10,14H2,1-2H3,(H,26,27) | PDB
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Indiana University Research and Technology Corporation
US Patent
| Assay Description
EMSA reactions (20 μL) were performed with 50 nM fl-RPA and 2.5 nM 5′[32P]-labeled 34-base DNA in buffer containing 20 mM HEPES (pH 7.0), ... |
US Patent US10774063 (2020)
BindingDB Entry DOI: 10.7270/Q21N8479 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM461291
(US10774063, Compound NG-01-04)Show SMILES CCOc1ccc2cc(C3CC(=NN3c3ccc(cc3)C(O)=O)c3ccc(I)cc3)c(Cl)nc2c1 |c:11| Show InChI InChI=1S/C27H21ClIN3O3/c1-2-35-21-12-7-18-13-22(26(28)30-23(18)14-21)25-15-24(16-3-8-19(29)9-4-16)31-32(25)20-10-5-17(6-11-20)27(33)34/h3-14,25H,2,15H2,1H3,(H,33,34) | PDB
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| |
US Patent US10774063 (2020)
BindingDB Entry DOI: 10.7270/Q21N8479 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM461283
(US10774063, Compound TDRL-539)Show SMILES COc1ccc2cc(C3CC(=NN3C(=O)CCCCC(O)=O)c3ccc(F)cc3)c(Cl)nc2c1 |c:10| Show InChI InChI=1S/C25H23ClFN3O4/c1-34-18-11-8-16-12-19(25(26)28-20(16)13-18)22-14-21(15-6-9-17(27)10-7-15)29-30(22)23(31)4-2-3-5-24(32)33/h6-13,22H,2-5,14H2,1H3,(H,32,33) | PDB
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| |
US Patent US10774063 (2020)
BindingDB Entry DOI: 10.7270/Q21N8479 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM461281
(US10774063, Compound TDRL-540)Show SMILES COc1ccc2cc(C3CC(=NN3C(=O)CCCC(O)=O)c3ccc(F)cc3)c(Cl)nc2c1 |c:10| Show InChI InChI=1S/C24H21ClFN3O4/c1-33-17-10-7-15-11-18(24(25)27-19(15)12-17)21-13-20(14-5-8-16(26)9-6-14)28-29(21)22(30)3-2-4-23(31)32/h5-12,21H,2-4,13H2,1H3,(H,31,32) | PDB
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| |
US Patent US10774063 (2020)
BindingDB Entry DOI: 10.7270/Q21N8479 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM461278
(US10774063, Compound l)Show SMILES OC(=O)CCCC(=O)N1N=C(CC1c1cc2cc3OCCOc3cc2nc1Cl)c1ccccc1 |c:9| Show InChI InChI=1S/C25H22ClN3O5/c26-25-17(11-16-12-21-22(14-18(16)27-25)34-10-9-33-21)20-13-19(15-5-2-1-3-6-15)28-29(20)23(30)7-4-8-24(31)32/h1-3,5-6,11-12,14,20H,4,7-10,13H2,(H,31,32) | PDB
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US Patent
| Assay Description
EMSA reactions (20 μL) were performed with 50 nM fl-RPA and 2.5 nM 5′[32P]-labeled 34-base DNA in buffer containing 20 mM HEPES (pH 7.0), ... |
US Patent US10774063 (2020)
BindingDB Entry DOI: 10.7270/Q21N8479 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM461277
(US10774063, Compound k)Show SMILES COc1ccc2cc(C3CC(=NN3C(=O)CCCC(O)=O)c3ccc(OC)c(OC)c3)c(Cl)nc2c1 |c:10| Show InChI InChI=1S/C26H26ClN3O6/c1-34-17-9-7-15-11-18(26(27)28-19(15)13-17)21-14-20(16-8-10-22(35-2)23(12-16)36-3)29-30(21)24(31)5-4-6-25(32)33/h7-13,21H,4-6,14H2,1-3H3,(H,32,33) | PDB
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Indiana University Research and Technology Corporation
US Patent
| Assay Description
EMSA reactions (20 μL) were performed with 50 nM fl-RPA and 2.5 nM 5′[32P]-labeled 34-base DNA in buffer containing 20 mM HEPES (pH 7.0), ... |
US Patent US10774063 (2020)
BindingDB Entry DOI: 10.7270/Q21N8479 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM260650
(US9533969, TDRL-523)Show SMILES COc1ccc(cc1)-c1nn(cc1C1CC(=NN1C(=O)CCC(O)=O)c1ccc(Br)cc1)-c1ccccc1 |c:17| Show InChI InChI=1S/C29H25BrN4O4/c1-38-23-13-9-20(10-14-23)29-24(18-33(32-29)22-5-3-2-4-6-22)26-17-25(19-7-11-21(30)12-8-19)31-34(26)27(35)15-16-28(36)37/h2-14,18,26H,15-17H2,1H3,(H,36,37) | PDB
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US Patent
| Assay Description
Small molecule inhibitors were obtained from ChemDiv and resuspended in DMSO. Compound TDLR-505 was independently synthesized and structure confirmed... |
US Patent US9533969 (2017)
BindingDB Entry DOI: 10.7270/Q2445KDJ |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM461275
(US10774063, Compound i)Show SMILES COc1ccc2cc(C3CC(=NN3C(=O)CCCC(O)=O)c3ccc(C)cc3)c(Cl)nc2c1 |c:10| Show InChI InChI=1S/C25H24ClN3O4/c1-15-6-8-16(9-7-15)21-14-22(29(28-21)23(30)4-3-5-24(31)32)19-12-17-10-11-18(33-2)13-20(17)27-25(19)26/h6-13,22H,3-5,14H2,1-2H3,(H,31,32) | PDB
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US Patent
| Assay Description
EMSA reactions (20 μL) were performed with 50 nM fl-RPA and 2.5 nM 5′[32P]-labeled 34-base DNA in buffer containing 20 mM HEPES (pH 7.0), ... |
US Patent US10774063 (2020)
BindingDB Entry DOI: 10.7270/Q21N8479 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM260647
(US9533969, TDRL-518)Show SMILES CCN(CC)c1ccc(cc1)C1CC(=NN1C(=O)CCC(O)=O)c1ccc(Br)cc1 |c:14| Show InChI InChI=1S/C23H26BrN3O3/c1-3-26(4-2)19-11-7-17(8-12-19)21-15-20(16-5-9-18(24)10-6-16)25-27(21)22(28)13-14-23(29)30/h5-12,21H,3-4,13-15H2,1-2H3,(H,29,30) | PDB
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US Patent
| Assay Description
Small molecule inhibitors were obtained from ChemDiv and resuspended in DMSO. Compound TDLR-505 was independently synthesized and structure confirmed... |
US Patent US9533969 (2017)
BindingDB Entry DOI: 10.7270/Q2445KDJ |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM50006654
(CHEMBL3236278)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C69H104N16O31/c1-28(2)20-39(61(108)72-31(6)58(105)83-46(27-86)55(70)102)82-69(116)54(34(9)88)85-67(114)45(26-52(100)101)78-56(103)30(5)71-59(106)37(16-18-47(90)91)75-60(107)38(17-19-48(92)93)76-62(109)40(21-29(3)4)79-65(112)44(25-51(98)99)81-64(111)43(24-50(96)97)77-57(104)32(7)73-68(115)53(33(8)87)84-66(113)41(22-36-14-12-11-13-15-36)80-63(110)42(23-49(94)95)74-35(10)89/h11-15,28-34,37-46,53-54,86-88H,16-27H2,1-10H3,(H2,70,102)(H,71,106)(H,72,108)(H,73,115)(H,74,89)(H,75,107)(H,76,109)(H,77,104)(H,78,103)(H,79,112)(H,80,110)(H,81,111)(H,82,116)(H,83,105)(H,84,113)(H,85,114)(H,90,91)(H,92,93)(H,94,95)(H,96,97)(H,98,99)(H,100,101)/t30-,31-,32-,33+,34+,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,53-,54-/m0/s1 | PDB
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| n/a | n/a | n/a | 1.97E+5 | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University School of Medicine
Curated by ChEMBL
| Assay Description
Binding affinity to recombinant human RPA70 N-terminal domain (1 to 120 amino acids) expressed in Escherichia coli BL21-DE3 by fluorescence polarizat... |
J Med Chem 57: 2455-61 (2014)
Article DOI: 10.1021/jm401730y
BindingDB Entry DOI: 10.7270/Q29888H7 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM50006655
(CHEMBL3236277)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C71H110N16O29/c1-30(2)22-42(63(108)74-35(9)60(105)86-56(37(11)90)71(116)84-43(23-31(3)4)64(109)73-33(7)59(104)85-49(29-88)57(72)102)80-62(107)41(19-21-51(94)95)77-61(106)40(18-20-50(92)93)78-65(110)44(24-32(5)6)81-68(113)48(28-54(100)101)83-67(112)47(27-53(98)99)79-58(103)34(8)75-70(115)55(36(10)89)87-69(114)45(25-39-16-14-13-15-17-39)82-66(111)46(26-52(96)97)76-38(12)91/h13-17,30-37,40-49,55-56,88-90H,18-29H2,1-12H3,(H2,72,102)(H,73,109)(H,74,108)(H,75,115)(H,76,91)(H,77,106)(H,78,110)(H,79,103)(H,80,107)(H,81,113)(H,82,111)(H,83,112)(H,84,116)(H,85,104)(H,86,105)(H,87,114)(H,92,93)(H,94,95)(H,96,97)(H,98,99)(H,100,101)/t33-,34-,35-,36+,37+,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,55-,56-/m0/s1 | PDB
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| n/a | n/a | n/a | 8.50E+4 | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University School of Medicine
Curated by ChEMBL
| Assay Description
Binding affinity to recombinant human RPA70 N-terminal domain (1 to 120 amino acids) expressed in Escherichia coli BL21-DE3 by fluorescence polarizat... |
J Med Chem 57: 2455-61 (2014)
Article DOI: 10.1021/jm401730y
BindingDB Entry DOI: 10.7270/Q29888H7 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM50006656
(CHEMBL3236276)Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C71H108N16O30/c1-30(2)21-41(63(109)73-34(8)60(106)86-49(29-88)57(72)103)79-58(104)33(7)74-64(110)46(26-53(97)98)84-66(112)43(23-32(5)6)81-62(108)40(18-20-51(93)94)77-61(107)39(17-19-50(91)92)78-65(111)42(22-31(3)4)82-69(115)48(28-55(101)102)85-68(114)47(27-54(99)100)80-59(105)35(9)75-71(117)56(36(10)89)87-70(116)44(24-38-15-13-12-14-16-38)83-67(113)45(25-52(95)96)76-37(11)90/h12-16,30-36,39-49,56,88-89H,17-29H2,1-11H3,(H2,72,103)(H,73,109)(H,74,110)(H,75,117)(H,76,90)(H,77,107)(H,78,111)(H,79,104)(H,80,105)(H,81,108)(H,82,115)(H,83,113)(H,84,112)(H,85,114)(H,86,106)(H,87,116)(H,91,92)(H,93,94)(H,95,96)(H,97,98)(H,99,100)(H,101,102)/t33-,34-,35-,36+,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,56-/m0/s1 | PDB
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| n/a | n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University School of Medicine
Curated by ChEMBL
| Assay Description
Binding affinity to recombinant human RPA70 N-terminal domain (1 to 120 amino acids) expressed in Escherichia coli BL21-DE3 by fluorescence polarizat... |
J Med Chem 57: 2455-61 (2014)
Article DOI: 10.1021/jm401730y
BindingDB Entry DOI: 10.7270/Q29888H7 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM50006657
(CHEMBL3236275)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C69H104N16O31/c1-28(2)20-39(79-65(112)44(25-51(98)99)81-64(111)43(24-50(96)97)77-57(104)32(7)73-69(116)53(33(8)87)84-66(113)41(22-36-14-12-11-13-15-36)80-63(110)42(23-49(94)95)74-35(10)89)61(108)76-37(16-18-47(90)91)59(106)75-38(17-19-48(92)93)60(107)78-40(21-29(3)4)62(109)82-45(26-52(100)101)67(114)85-54(34(9)88)68(115)72-30(5)56(103)71-31(6)58(105)83-46(27-86)55(70)102/h11-15,28-34,37-46,53-54,86-88H,16-27H2,1-10H3,(H2,70,102)(H,71,103)(H,72,115)(H,73,116)(H,74,89)(H,75,106)(H,76,108)(H,77,104)(H,78,107)(H,79,112)(H,80,110)(H,81,111)(H,82,109)(H,83,105)(H,84,113)(H,85,114)(H,90,91)(H,92,93)(H,94,95)(H,96,97)(H,98,99)(H,100,101)/t30-,31-,32-,33+,34+,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,53-,54-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 6.30E+4 | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University School of Medicine
Curated by ChEMBL
| Assay Description
Binding affinity to recombinant human RPA70 N-terminal domain (1 to 120 amino acids) expressed in Escherichia coli BL21-DE3 by fluorescence polarizat... |
J Med Chem 57: 2455-61 (2014)
Article DOI: 10.1021/jm401730y
BindingDB Entry DOI: 10.7270/Q29888H7 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM50006658
(CHEMBL3235924)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(N)=O |r| Show InChI InChI=1S/C72H110N16O30/c1-30(2)22-42(63(109)75-34(8)59(105)74-33(7)58(73)104)86-72(118)57(37(11)90)88-70(116)49(29-55(102)103)85-65(111)44(24-32(5)6)81-62(108)41(19-21-51(94)95)78-61(107)40(18-20-50(92)93)79-64(110)43(23-31(3)4)82-68(114)48(28-54(100)101)84-67(113)47(27-53(98)99)80-60(106)35(9)76-71(117)56(36(10)89)87-69(115)45(25-39-16-14-13-15-17-39)83-66(112)46(26-52(96)97)77-38(12)91/h13-17,30-37,40-49,56-57,89-90H,18-29H2,1-12H3,(H2,73,104)(H,74,105)(H,75,109)(H,76,117)(H,77,91)(H,78,107)(H,79,110)(H,80,106)(H,81,108)(H,82,114)(H,83,112)(H,84,113)(H,85,111)(H,86,118)(H,87,115)(H,88,116)(H,92,93)(H,94,95)(H,96,97)(H,98,99)(H,100,101)(H,102,103)/t33-,34-,35-,36+,37+,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,56-,57-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 2.60E+4 | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University School of Medicine
Curated by ChEMBL
| Assay Description
Binding affinity to recombinant human RPA70 N-terminal domain (1 to 120 amino acids) expressed in Escherichia coli BL21-DE3 by fluorescence polarizat... |
J Med Chem 57: 2455-61 (2014)
Article DOI: 10.1021/jm401730y
BindingDB Entry DOI: 10.7270/Q29888H7 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM50006659
(CHEMBL3235923)Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C69H106N16O28/c1-29(2)20-40(61(105)72-34(9)59(103)84-48(28-86)55(70)99)77-57(101)33(8)73-63(107)45(25-51(93)94)82-64(108)42(22-31(5)6)79-60(104)39(18-19-49(89)90)76-56(100)32(7)71-62(106)41(21-30(3)4)80-67(111)47(27-53(97)98)83-66(110)46(26-52(95)96)78-58(102)35(10)74-69(113)54(36(11)87)85-68(112)43(23-38-16-14-13-15-17-38)81-65(109)44(24-50(91)92)75-37(12)88/h13-17,29-36,39-48,54,86-87H,18-28H2,1-12H3,(H2,70,99)(H,71,106)(H,72,105)(H,73,107)(H,74,113)(H,75,88)(H,76,100)(H,77,101)(H,78,102)(H,79,104)(H,80,111)(H,81,109)(H,82,108)(H,83,110)(H,84,103)(H,85,112)(H,89,90)(H,91,92)(H,93,94)(H,95,96)(H,97,98)/t32-,33-,34-,35-,36+,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,54-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University School of Medicine
Curated by ChEMBL
| Assay Description
Binding affinity to recombinant human RPA70 N-terminal domain (1 to 120 amino acids) expressed in Escherichia coli BL21-DE3 by fluorescence polarizat... |
J Med Chem 57: 2455-61 (2014)
Article DOI: 10.1021/jm401730y
BindingDB Entry DOI: 10.7270/Q29888H7 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM50006660
(CHEMBL3235922)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C77H114N16O29/c1-35(2)26-47(68(113)79-38(7)65(110)91-55(34-94)63(78)108)90-77(122)62(41(10)96)93-75(120)50(29-43-18-14-12-15-19-43)87-70(115)49(28-37(5)6)85-67(112)46(23-25-57(100)101)82-66(111)45(22-24-56(98)99)83-69(114)48(27-36(3)4)86-73(118)54(33-60(106)107)89-72(117)53(32-59(104)105)84-64(109)39(8)80-76(121)61(40(9)95)92-74(119)51(30-44-20-16-13-17-21-44)88-71(116)52(31-58(102)103)81-42(11)97/h12-21,35-41,45-55,61-62,94-96H,22-34H2,1-11H3,(H2,78,108)(H,79,113)(H,80,121)(H,81,97)(H,82,111)(H,83,114)(H,84,109)(H,85,112)(H,86,118)(H,87,115)(H,88,116)(H,89,117)(H,90,122)(H,91,110)(H,92,119)(H,93,120)(H,98,99)(H,100,101)(H,102,103)(H,104,105)(H,106,107)/t38-,39-,40+,41+,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,61-,62-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University School of Medicine
Curated by ChEMBL
| Assay Description
Binding affinity to recombinant human RPA70 N-terminal domain (1 to 120 amino acids) expressed in Escherichia coli BL21-DE3 by fluorescence polarizat... |
J Med Chem 57: 2455-61 (2014)
Article DOI: 10.1021/jm401730y
BindingDB Entry DOI: 10.7270/Q29888H7 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM50006661
(CHEMBL3235921)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C77H109N17O31/c1-33(2)23-46(68(116)80-35(5)65(113)92-54(32-95)63(78)111)91-77(125)62(38(8)97)94-75(123)53(30-60(109)110)90-70(118)49(26-41-31-79-43-18-14-13-17-42(41)43)88-67(115)45(20-22-56(101)102)83-66(114)44(19-21-55(99)100)84-69(117)47(24-34(3)4)86-73(121)52(29-59(107)108)89-72(120)51(28-58(105)106)85-64(112)36(6)81-76(124)61(37(7)96)93-74(122)48(25-40-15-11-10-12-16-40)87-71(119)50(27-57(103)104)82-39(9)98/h10-18,31,33-38,44-54,61-62,79,95-97H,19-30,32H2,1-9H3,(H2,78,111)(H,80,116)(H,81,124)(H,82,98)(H,83,114)(H,84,117)(H,85,112)(H,86,121)(H,87,119)(H,88,115)(H,89,120)(H,90,118)(H,91,125)(H,92,113)(H,93,122)(H,94,123)(H,99,100)(H,101,102)(H,103,104)(H,105,106)(H,107,108)(H,109,110)/t35-,36-,37+,38+,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,61-,62-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | 1.38E+5 | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University School of Medicine
Curated by ChEMBL
| Assay Description
Binding affinity to recombinant human RPA70 N-terminal domain (1 to 120 amino acids) expressed in Escherichia coli BL21-DE3 by fluorescence polarizat... |
J Med Chem 57: 2455-61 (2014)
Article DOI: 10.1021/jm401730y
BindingDB Entry DOI: 10.7270/Q29888H7 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM50006662
(CHEMBL3235920)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C82H113N17O29/c1-38(2)28-52(73(119)85-40(5)70(116)97-60(37-100)68(83)114)96-82(128)67(43(8)102)99-80(126)54(30-45-18-12-10-13-19-45)92-75(121)56(32-47-36-84-49-23-17-16-22-48(47)49)94-72(118)51(25-27-62(106)107)88-71(117)50(24-26-61(104)105)89-74(120)53(29-39(3)4)91-78(124)59(35-65(112)113)95-77(123)58(34-64(110)111)90-69(115)41(6)86-81(127)66(42(7)101)98-79(125)55(31-46-20-14-11-15-21-46)93-76(122)57(33-63(108)109)87-44(9)103/h10-23,36,38-43,50-60,66-67,84,100-102H,24-35,37H2,1-9H3,(H2,83,114)(H,85,119)(H,86,127)(H,87,103)(H,88,117)(H,89,120)(H,90,115)(H,91,124)(H,92,121)(H,93,122)(H,94,118)(H,95,123)(H,96,128)(H,97,116)(H,98,125)(H,99,126)(H,104,105)(H,106,107)(H,108,109)(H,110,111)(H,112,113)/t40-,41-,42+,43+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,66-,67-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University School of Medicine
Curated by ChEMBL
| Assay Description
Binding affinity to recombinant human RPA70 N-terminal domain (1 to 120 amino acids) expressed in Escherichia coli BL21-DE3 by fluorescence polarizat... |
J Med Chem 57: 2455-61 (2014)
Article DOI: 10.1021/jm401730y
BindingDB Entry DOI: 10.7270/Q29888H7 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM50006663
(CHEMBL3235919)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C80H111N17O27/c1-37(2)27-51(89-76(120)58(34-63(108)109)93-75(119)57(33-62(106)107)88-68(112)41(7)85-79(123)64(42(8)99)96-77(121)54(30-46-21-15-12-16-22-46)91-74(118)56(32-61(104)105)86-44(10)101)71(115)83-39(5)67(111)87-50(25-26-60(102)103)70(114)92-55(31-47-35-82-49-24-18-17-23-48(47)49)73(117)90-53(29-45-19-13-11-14-20-45)78(122)97-65(43(9)100)80(124)94-52(28-38(3)4)72(116)84-40(6)69(113)95-59(36-98)66(81)110/h11-24,35,37-43,50-59,64-65,82,98-100H,25-34,36H2,1-10H3,(H2,81,110)(H,83,115)(H,84,116)(H,85,123)(H,86,101)(H,87,111)(H,88,112)(H,89,120)(H,90,117)(H,91,118)(H,92,114)(H,93,119)(H,94,124)(H,95,113)(H,96,121)(H,97,122)(H,102,103)(H,104,105)(H,106,107)(H,108,109)/t39-,40-,41-,42+,43+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,64-,65-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | 4.30E+4 | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University School of Medicine
Curated by ChEMBL
| Assay Description
Binding affinity to recombinant human RPA70 N-terminal domain (1 to 120 amino acids) expressed in Escherichia coli BL21-DE3 by fluorescence polarizat... |
J Med Chem 57: 2455-61 (2014)
Article DOI: 10.1021/jm401730y
BindingDB Entry DOI: 10.7270/Q29888H7 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM50006664
(CHEMBL3235918)Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C81H111N17O28/c1-38(2)28-52(73(118)84-41(6)70(115)97-60(37-99)67(82)112)90-68(113)40(5)85-74(119)54(30-45-18-12-10-13-19-45)93-76(121)56(32-47-36-83-49-23-17-16-22-48(47)49)95-72(117)51(25-27-62(104)105)88-71(116)50(24-26-61(102)103)89-75(120)53(29-39(3)4)92-79(124)59(35-65(110)111)96-78(123)58(34-64(108)109)91-69(114)42(7)86-81(126)66(43(8)100)98-80(125)55(31-46-20-14-11-15-21-46)94-77(122)57(33-63(106)107)87-44(9)101/h10-23,36,38-43,50-60,66,83,99-100H,24-35,37H2,1-9H3,(H2,82,112)(H,84,118)(H,85,119)(H,86,126)(H,87,101)(H,88,116)(H,89,120)(H,90,113)(H,91,114)(H,92,124)(H,93,121)(H,94,122)(H,95,117)(H,96,123)(H,97,115)(H,98,125)(H,102,103)(H,104,105)(H,106,107)(H,108,109)(H,110,111)/t40-,41-,42-,43+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,66-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University School of Medicine
Curated by ChEMBL
| Assay Description
Binding affinity to recombinant human RPA70 N-terminal domain (1 to 120 amino acids) expressed in Escherichia coli BL21-DE3 by fluorescence polarizat... |
J Med Chem 57: 2455-61 (2014)
Article DOI: 10.1021/jm401730y
BindingDB Entry DOI: 10.7270/Q29888H7 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM50006665
(CHEMBL3236288)Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=S)Nc1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(N)=O |r,wU:100.104,85.88,72.75,56.59,134.143,4.3,38.41,13.13,145.153,wD:64.67,80.83,140.148,89.92,8.8,47.50,24.25,(64.07,-11.82,;62.73,-11.04,;62.73,-9.51,;61.4,-11.82,;61.4,-13.36,;60.06,-14.12,;58.73,-13.36,;58.73,-11.82,;57.39,-14.12,;57.39,-15.67,;56.06,-13.36,;54.72,-14.12,;54.72,-15.66,;53.39,-13.35,;53.39,-11.82,;54.72,-11.04,;54.73,-9.5,;56.06,-8.74,;57.4,-9.5,;57.4,-11.04,;56.06,-11.82,;52.05,-14.12,;50.71,-13.35,;50.71,-11.81,;49.38,-14.11,;49.38,-15.66,;50.71,-16.43,;52.12,-15.8,;53.13,-16.95,;52.36,-18.29,;52.85,-19.75,;51.81,-20.91,;50.3,-20.58,;49.84,-19.12,;50.87,-17.97,;48.05,-13.35,;46.71,-14.11,;46.71,-15.65,;45.38,-13.34,;45.38,-11.81,;46.71,-11.03,;46.71,-9.49,;45.38,-8.73,;48.05,-8.72,;44.04,-14.11,;42.71,-13.34,;42.71,-11.8,;41.37,-14.1,;41.37,-15.65,;42.71,-16.42,;42.71,-17.97,;41.37,-18.73,;44.04,-18.73,;40.03,-13.34,;38.7,-14.1,;38.7,-15.64,;37.37,-13.33,;37.37,-11.8,;38.7,-11.02,;40.03,-11.8,;38.7,-9.48,;36.03,-14.1,;34.69,-13.33,;34.69,-11.79,;33.37,-14.09,;33.37,-15.64,;34.69,-16.41,;36.03,-15.64,;34.69,-17.96,;32.03,-13.33,;30.7,-14.09,;30.7,-15.63,;29.35,-13.33,;29.35,-11.79,;30.7,-11.01,;32.03,-11.79,;30.7,-9.47,;28.03,-14.09,;26.69,-13.32,;26.69,-11.78,;25.36,-14.08,;25.36,-15.63,;24.01,-13.32,;22.69,-14.08,;22.69,-15.62,;21.35,-13.32,;20.02,-14.08,;18.68,-13.31,;18.68,-11.77,;17.35,-14.07,;17.35,-15.62,;18.68,-16.4,;18.67,-17.94,;19.99,-18.71,;21.33,-17.95,;21.33,-16.41,;20,-15.62,;16.01,-13.31,;14.67,-14.07,;14.67,-15.62,;13.34,-13.31,;13.34,-11.77,;14.68,-10.99,;16.01,-11.77,;14.68,-9.45,;12.01,-14.07,;10.69,-13.29,;10.71,-11.76,;9.36,-14.04,;8.04,-13.26,;6.72,-14,;5.39,-13.21,;5.41,-11.67,;6.75,-10.93,;8.07,-11.72,;7.16,-9.45,;8.65,-9.06,;6.08,-8.36,;4.08,-10.88,;2.75,-11.63,;2.73,-13.16,;1.38,-13.9,;.07,-13.12,;-1.29,-13.86,;.09,-11.58,;1.44,-10.84,;1.45,-9.3,;2.8,-8.57,;2.82,-7.03,;4.17,-6.27,;4.18,-4.72,;5.48,-7.07,;5.45,-8.6,;4.11,-9.35,;21.35,-11.78,;20.02,-11,;22.69,-11,;62.73,-14.13,;62.73,-15.67,;64.07,-13.37,;65.4,-14.13,;65.4,-15.68,;66.74,-13.37,;66.74,-11.83,;68.07,-14.13,;69.41,-13.37,;69.41,-11.83,;70.74,-11.05,;70.74,-14.14,;72.07,-13.38,;70.74,-15.68,)| Show InChI InChI=1S/C100H120N18O32S/c1-46(2)33-66(90(139)103-49(6)87(136)116-74(45-119)84(101)133)109-85(134)48(5)104-91(140)68(35-52-17-11-9-12-18-52)112-93(142)70(37-54-44-102-63-22-16-15-21-58(54)63)114-89(138)65(30-32-78(125)126)107-88(137)64(29-31-77(123)124)108-92(141)67(34-47(3)4)111-95(144)72(42-80(129)130)115-94(143)71(41-79(127)128)110-86(135)50(7)105-98(147)83(51(8)120)118-97(146)69(36-53-19-13-10-14-20-53)113-96(145)73(43-81(131)132)117-100(151)106-55-23-26-59(62(38-55)99(148)149)82-60-27-24-56(121)39-75(60)150-76-40-57(122)25-28-61(76)82/h9-28,38-40,44,46-51,64-74,83,102,119-121H,29-37,41-43,45H2,1-8H3,(H2,101,133)(H,103,139)(H,104,140)(H,105,147)(H,107,137)(H,108,141)(H,109,134)(H,110,135)(H,111,144)(H,112,142)(H,113,145)(H,114,138)(H,115,143)(H,116,136)(H,118,146)(H,123,124)(H,125,126)(H,127,128)(H,129,130)(H,131,132)(H,148,149)(H2,106,117,151)/t48-,49-,50-,51+,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,83-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 480 | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University School of Medicine
Curated by ChEMBL
| Assay Description
Binding affinity to recombinant human RPA70 N-terminal domain (1 to 120 amino acids) expressed in Escherichia coli BL21-DE3 by fluorescence polarizat... |
J Med Chem 57: 2455-61 (2014)
Article DOI: 10.1021/jm401730y
BindingDB Entry DOI: 10.7270/Q29888H7 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM50006666
(CHEMBL3236289)Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C81H112N18O27/c1-38(2)28-52(73(118)85-41(6)70(115)98-60(37-100)67(83)112)91-68(113)40(5)86-74(119)54(30-45-18-12-10-13-19-45)94-76(121)56(32-47-36-84-49-23-17-16-22-48(47)49)96-72(117)51(25-27-63(106)107)89-71(116)50(24-26-62(104)105)90-75(120)53(29-39(3)4)93-79(124)59(35-65(110)111)97-78(123)58(34-64(108)109)92-69(114)42(7)87-81(126)66(43(8)101)99-80(125)55(31-46-20-14-11-15-21-46)95-77(122)57(33-61(82)103)88-44(9)102/h10-23,36,38-43,50-60,66,84,100-101H,24-35,37H2,1-9H3,(H2,82,103)(H2,83,112)(H,85,118)(H,86,119)(H,87,126)(H,88,102)(H,89,116)(H,90,120)(H,91,113)(H,92,114)(H,93,124)(H,94,121)(H,95,122)(H,96,117)(H,97,123)(H,98,115)(H,99,125)(H,104,105)(H,106,107)(H,108,109)(H,110,111)/t40-,41-,42-,43+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,66-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | 5.80E+3 | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University School of Medicine
Curated by ChEMBL
| Assay Description
Binding affinity to recombinant human RPA70 N-terminal domain (1 to 120 amino acids) expressed in Escherichia coli BL21-DE3 by fluorescence polarizat... |
J Med Chem 57: 2455-61 (2014)
Article DOI: 10.1021/jm401730y
BindingDB Entry DOI: 10.7270/Q29888H7 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM50006667
(CHEMBL3236290)Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C80H111N17O26/c1-38(2)29-53(73(116)84-43(8)70(113)96-60(37-98)66(81)109)90-69(112)42(7)85-74(117)55(31-46-19-13-11-14-20-46)93-76(119)57(33-48-36-82-50-24-18-17-23-49(48)50)95-72(115)52(26-28-62(103)104)88-71(114)51(25-27-61(101)102)89-75(118)54(30-39(3)4)92-78(121)59(35-64(107)108)91-68(111)41(6)83-67(110)40(5)86-80(123)65(44(9)99)97-79(122)56(32-47-21-15-12-16-22-47)94-77(120)58(34-63(105)106)87-45(10)100/h11-24,36,38-44,51-60,65,82,98-99H,25-35,37H2,1-10H3,(H2,81,109)(H,83,110)(H,84,116)(H,85,117)(H,86,123)(H,87,100)(H,88,114)(H,89,118)(H,90,112)(H,91,111)(H,92,121)(H,93,119)(H,94,120)(H,95,115)(H,96,113)(H,97,122)(H,101,102)(H,103,104)(H,105,106)(H,107,108)/t40-,41-,42-,43-,44+,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,65-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University School of Medicine
Curated by ChEMBL
| Assay Description
Binding affinity to recombinant human RPA70 N-terminal domain (1 to 120 amino acids) expressed in Escherichia coli BL21-DE3 by fluorescence polarizat... |
J Med Chem 57: 2455-61 (2014)
Article DOI: 10.1021/jm401730y
BindingDB Entry DOI: 10.7270/Q29888H7 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM50006668
(CHEMBL3236291)Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C81H112N18O27/c1-38(2)28-52(73(118)85-41(6)70(115)98-60(37-100)67(83)112)91-68(113)40(5)86-74(119)54(30-45-18-12-10-13-19-45)94-76(121)56(32-47-36-84-49-23-17-16-22-48(47)49)96-72(117)51(25-27-63(106)107)89-71(116)50(24-26-62(104)105)90-75(120)53(29-39(3)4)93-79(124)59(35-65(110)111)97-77(122)57(33-61(82)103)92-69(114)42(7)87-81(126)66(43(8)101)99-80(125)55(31-46-20-14-11-15-21-46)95-78(123)58(34-64(108)109)88-44(9)102/h10-23,36,38-43,50-60,66,84,100-101H,24-35,37H2,1-9H3,(H2,82,103)(H2,83,112)(H,85,118)(H,86,119)(H,87,126)(H,88,102)(H,89,116)(H,90,120)(H,91,113)(H,92,114)(H,93,124)(H,94,121)(H,95,123)(H,96,117)(H,97,122)(H,98,115)(H,99,125)(H,104,105)(H,106,107)(H,108,109)(H,110,111)/t40-,41-,42-,43+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,66-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 1.90E+4 | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University School of Medicine
Curated by ChEMBL
| Assay Description
Binding affinity to recombinant human RPA70 N-terminal domain (1 to 120 amino acids) expressed in Escherichia coli BL21-DE3 by fluorescence polarizat... |
J Med Chem 57: 2455-61 (2014)
Article DOI: 10.1021/jm401730y
BindingDB Entry DOI: 10.7270/Q29888H7 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM50006669
(CHEMBL3236292)Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C80H111N17O26/c1-38(2)29-53(73(116)83-42(7)70(113)96-60(37-98)66(81)109)90-67(110)40(5)84-74(117)55(31-46-19-13-11-14-20-46)93-77(120)57(33-48-36-82-50-24-18-17-23-49(48)50)95-72(115)52(26-28-62(103)104)88-71(114)51(25-27-61(101)102)89-76(119)54(30-39(3)4)91-68(111)41(6)85-75(118)59(35-64(107)108)92-69(112)43(8)86-80(123)65(44(9)99)97-79(122)56(32-47-21-15-12-16-22-47)94-78(121)58(34-63(105)106)87-45(10)100/h11-24,36,38-44,51-60,65,82,98-99H,25-35,37H2,1-10H3,(H2,81,109)(H,83,116)(H,84,117)(H,85,118)(H,86,123)(H,87,100)(H,88,114)(H,89,119)(H,90,110)(H,91,111)(H,92,112)(H,93,120)(H,94,121)(H,95,115)(H,96,113)(H,97,122)(H,101,102)(H,103,104)(H,105,106)(H,107,108)/t40-,41-,42-,43-,44+,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,65-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | 2.80E+4 | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University School of Medicine
Curated by ChEMBL
| Assay Description
Binding affinity to recombinant human RPA70 N-terminal domain (1 to 120 amino acids) expressed in Escherichia coli BL21-DE3 by fluorescence polarizat... |
J Med Chem 57: 2455-61 (2014)
Article DOI: 10.1021/jm401730y
BindingDB Entry DOI: 10.7270/Q29888H7 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM50006670
(CHEMBL3236293)Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C81H112N18O27/c1-38(2)28-52(73(118)85-41(6)70(115)98-60(37-100)67(83)112)91-68(113)40(5)86-74(119)54(30-45-18-12-10-13-19-45)94-76(121)56(32-47-36-84-49-23-17-16-22-48(47)49)96-72(117)51(25-27-63(106)107)89-71(116)50(24-26-62(104)105)90-75(120)53(29-39(3)4)93-77(122)57(33-61(82)103)97-79(124)59(35-65(110)111)92-69(114)42(7)87-81(126)66(43(8)101)99-80(125)55(31-46-20-14-11-15-21-46)95-78(123)58(34-64(108)109)88-44(9)102/h10-23,36,38-43,50-60,66,84,100-101H,24-35,37H2,1-9H3,(H2,82,103)(H2,83,112)(H,85,118)(H,86,119)(H,87,126)(H,88,102)(H,89,116)(H,90,120)(H,91,113)(H,92,114)(H,93,122)(H,94,121)(H,95,123)(H,96,117)(H,97,124)(H,98,115)(H,99,125)(H,104,105)(H,106,107)(H,108,109)(H,110,111)/t40-,41-,42-,43+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,66-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 6.90E+3 | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University School of Medicine
Curated by ChEMBL
| Assay Description
Binding affinity to recombinant human RPA70 N-terminal domain (1 to 120 amino acids) expressed in Escherichia coli BL21-DE3 by fluorescence polarizat... |
J Med Chem 57: 2455-61 (2014)
Article DOI: 10.1021/jm401730y
BindingDB Entry DOI: 10.7270/Q29888H7 |
More data for this
Ligand-Target Pair | |
Replication protein A 70 kDa DNA-binding subunit
(Homo sapiens (Human)) | BDBM50006671
(CHEMBL3236294)Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C79H109N17O26/c1-37(2)27-51(71(114)83-41(7)69(112)95-59(36-97)65(80)108)88-67(110)40(6)84-73(116)53(29-45-19-13-11-14-20-45)91-74(117)55(31-47-35-81-49-24-18-17-23-48(47)49)93-70(113)50(25-26-60(100)101)87-66(109)39(5)82-72(115)52(28-38(3)4)90-77(120)58(34-63(106)107)94-76(119)57(33-62(104)105)89-68(111)42(8)85-79(122)64(43(9)98)96-78(121)54(30-46-21-15-12-16-22-46)92-75(118)56(32-61(102)103)86-44(10)99/h11-24,35,37-43,50-59,64,81,97-98H,25-34,36H2,1-10H3,(H2,80,108)(H,82,115)(H,83,114)(H,84,116)(H,85,122)(H,86,99)(H,87,109)(H,88,110)(H,89,111)(H,90,120)(H,91,117)(H,92,118)(H,93,113)(H,94,119)(H,95,112)(H,96,121)(H,100,101)(H,102,103)(H,104,105)(H,106,107)/t39-,40-,41-,42-,43+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,64-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | n/a | 2.80E+4 | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University School of Medicine
Curated by ChEMBL
| Assay Description
Binding affinity to recombinant human RPA70 N-terminal domain (1 to 120 amino acids) expressed in Escherichia coli BL21-DE3 by fluorescence polarizat... |
J Med Chem 57: 2455-61 (2014)
Article DOI: 10.1021/jm401730y
BindingDB Entry DOI: 10.7270/Q29888H7 |
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Ligand-Target Pair | |
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