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Compile Data Set for Download or QSAR

Found 72 hits of ec50 for UniProtKB: P13866   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50346266
PNG
((2R,3R,4S,5S,6R)-2-(4-chloro-3-(4-cyclopropylbenzy...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12 |r|
Show InChI InChI=1S/C24H26ClNO5/c25-17-2-1-3-18-20(17)16(10-13-4-6-14(7-5-13)15-8-9-15)11-26(18)24-23(30)22(29)21(28)19(12-27)31-24/h1-7,11,15,19,21-24,27-30H,8-10,12H2/t19-,21-,22+,23-,24-/m1/s1
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n/an/an/an/a 27n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method

Bioorg Med Chem 24: 2242-50 (2016)


Article DOI: 10.1016/j.bmc.2016.03.058
BindingDB Entry DOI: 10.7270/Q25D8TQP
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50543520
PNG
(CHEMBL4642473)
Show SMILES ONC[C@H]1C[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12 |r|
Show InChI InChI=1S/C25H29ClN2O4/c26-19-2-1-3-20-22(19)18(10-14-4-6-15(7-5-14)16-8-9-16)13-28(20)21-11-17(12-27-32)23(29)25(31)24(21)30/h1-7,13,16-17,21,23-25,27,29-32H,8-12H2/t17-,21-,23-,24+,25+/m1/s1
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n/an/an/an/a 37n/an/an/an/a



Mizoram University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2019.115263
BindingDB Entry DOI: 10.7270/Q2T43XN8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50595440
PNG
(CHEMBL5169442)
Show SMILES CC(=O)NNC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12 |r|
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n/an/an/an/a 37n/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c00867
BindingDB Entry DOI: 10.7270/Q2FB570W
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50389351
PNG
(CHEMBL2064101)
Show SMILES Cc1cccc2c(cn(Cc3ccc(cc3)C3CC3)c12)[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C24H27NO4/c1-14-3-2-4-18-19(24-23(28)22(27)20(26)13-29-24)12-25(21(14)18)11-15-5-7-16(8-6-15)17-9-10-17/h2-8,12,17,20,22-24,26-28H,9-11,13H2,1H3/t20-,22+,23-,24+/m1/s1
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n/an/an/an/a 55n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells incubated for 120 mins at 37 degC by [14C]-AMG uptake assay

Eur J Med Chem 55: 32-8 (2012)


Article DOI: 10.1016/j.ejmech.2012.06.053
BindingDB Entry DOI: 10.7270/Q2S183K0
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM20875
PNG
(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Show SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
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n/an/an/an/a 120n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method

Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM20875
PNG
(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Show SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
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n/an/an/an/a 153n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method

Bioorg Med Chem 24: 2242-50 (2016)


Article DOI: 10.1016/j.bmc.2016.03.058
BindingDB Entry DOI: 10.7270/Q25D8TQP
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM20875
PNG
(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Show SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
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n/an/an/an/a 197n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...

J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50335145
PNG
(4-Chloro-3-(4-cyclopropylbenzyl)-1-(beta-D-xylopyr...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12 |r|
Show InChI InChI=1S/C23H24ClNO4/c24-17-2-1-3-18-20(17)16(10-13-4-6-14(7-5-13)15-8-9-15)11-25(18)23-22(28)21(27)19(26)12-29-23/h1-7,11,15,19,21-23,26-28H,8-10,12H2/t19-,21+,22-,23-/m1/s1
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n/an/an/an/a 209n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...

J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM20877
PNG
(3-(1-benzofuran-5-yl)-1-(2-hydroxy-4-methyl-6-{[(2...)
Show SMILES Cc1cc(O)c(C(=O)CCc2ccc3occc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C24H26O9/c1-12-8-16(27)20(15(26)4-2-13-3-5-17-14(10-13)6-7-31-17)18(9-12)32-24-23(30)22(29)21(28)19(11-25)33-24/h3,5-10,19,21-25,27-30H,2,4,11H2,1H3/t19-,21-,22+,23-,24-/m1/s1
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n/an/an/an/a 211n/an/a7.222



Bristol-Myers Squibb Company



Assay Description
Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...

J Med Chem 51: 1145-9 (2008)


Article DOI: 10.1021/jm701272q
BindingDB Entry DOI: 10.7270/Q2PN93X4
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50335131
PNG
(4-Chloro-3-(4-methoxybenzyl)-1-(beta-D-xylopyranos...)
Show SMILES COc1ccc(Cc2cn([C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)c3cccc(Cl)c23)cc1 |r|
Show InChI InChI=1S/C21H22ClNO5/c1-27-14-7-5-12(6-8-14)9-13-10-23(16-4-2-3-15(22)18(13)16)21-20(26)19(25)17(24)11-28-21/h2-8,10,17,19-21,24-26H,9,11H2,1H3/t17-,19+,20-,21-/m1/s1
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Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...

J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50335146
PNG
(4-Chloro-3-(4-hydroxybenzyl)-1-(beta-D-xylopyranos...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc(O)cc2)c2c(Cl)cccc12 |r|
Show InChI InChI=1S/C20H20ClNO5/c21-14-2-1-3-15-17(14)12(8-11-4-6-13(23)7-5-11)9-22(15)20-19(26)18(25)16(24)10-27-20/h1-7,9,16,18-20,23-26H,8,10H2/t16-,18+,19-,20-/m1/s1
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n/an/an/an/a 234n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...

J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM20877
PNG
(3-(1-benzofuran-5-yl)-1-(2-hydroxy-4-methyl-6-{[(2...)
Show SMILES Cc1cc(O)c(C(=O)CCc2ccc3occc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C24H26O9/c1-12-8-16(27)20(15(26)4-2-13-3-5-17-14(10-13)6-7-31-17)18(9-12)32-24-23(30)22(29)21(28)19(11-25)33-24/h3,5-10,19,21-25,27-30H,2,4,11H2,1H3/t19-,21-,22+,23-,24-/m1/s1
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TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c00867
BindingDB Entry DOI: 10.7270/Q2FB570W
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM20875
PNG
(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Show SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
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n/an/an/an/a 240n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting method

Eur J Med Chem 143: 611-620 (2018)


Article DOI: 10.1016/j.ejmech.2017.11.019
BindingDB Entry DOI: 10.7270/Q2MK6GFZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50389350
PNG
(CHEMBL2064100)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)c1cn(Cc2ccc(cc2)C2CC2)c2c(F)cccc12 |r|
Show InChI InChI=1S/C23H24FNO4/c24-18-3-1-2-16-17(23-22(28)21(27)19(26)12-29-23)11-25(20(16)18)10-13-4-6-14(7-5-13)15-8-9-15/h1-7,11,15,19,21-23,26-28H,8-10,12H2/t19-,21+,22-,23+/m1/s1
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n/an/an/an/a 282n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells incubated for 120 mins at 37 degC by [14C]-AMG uptake assay

Eur J Med Chem 55: 32-8 (2012)


Article DOI: 10.1016/j.ejmech.2012.06.053
BindingDB Entry DOI: 10.7270/Q2S183K0
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50335139
PNG
(4-Chloro-3-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc3OCCOc3c2)c2c(Cl)cccc12 |r|
Show InChI InChI=1S/C22H22ClNO6/c23-14-2-1-3-15-19(14)13(8-12-4-5-17-18(9-12)29-7-6-28-17)10-24(15)22-21(27)20(26)16(25)11-30-22/h1-5,9-10,16,20-22,25-27H,6-8,11H2/t16-,20+,21-,22-/m1/s1
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Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...

J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50335150
PNG
(4-Bromo-3-(4-cyclopropylbenzyl)-1-(beta-D-xylopyra...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Br)cccc12 |r|
Show InChI InChI=1S/C23H24BrNO4/c24-17-2-1-3-18-20(17)16(10-13-4-6-14(7-5-13)15-8-9-15)11-25(18)23-22(28)21(27)19(26)12-29-23/h1-7,11,15,19,21-23,26-28H,8-10,12H2/t19-,21+,22-,23-/m1/s1
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Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...

J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM20875
PNG
(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Show SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
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n/an/an/an/a 330n/an/a7.222



Bristol-Myers Squibb Company



Assay Description
Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...

J Med Chem 51: 1145-9 (2008)


Article DOI: 10.1021/jm701272q
BindingDB Entry DOI: 10.7270/Q2PN93X4
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50511115
PNG
(CHEMBL4552590)
Show SMILES OC[C@H]1O[C@@H](Oc2ccccc2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C21H24O8/c22-11-17-18(25)19(26)20(27)21(29-17)28-16-4-2-1-3-14(16)15(24)10-7-12-5-8-13(23)9-6-12/h1-6,8-9,17-23,25-27H,7,10-11H2/t17-,18-,19+,20-,21-/m1/s1
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n/an/an/an/a 330n/an/an/an/a



Terns Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of SGLT1 (unknown origin)

J Med Chem 63: 5031-5073 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01701
BindingDB Entry DOI: 10.7270/Q2DJ5JXG
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50335145
PNG
(4-Chloro-3-(4-cyclopropylbenzyl)-1-(beta-D-xylopyr...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12 |r|
Show InChI InChI=1S/C23H24ClNO4/c24-17-2-1-3-18-20(17)16(10-13-4-6-14(7-5-13)15-8-9-15)11-25(18)23-22(28)21(27)19(26)12-29-23/h1-7,11,15,19,21-23,26-28H,8-10,12H2/t19-,21+,22-,23-/m1/s1
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n/an/an/an/a 364n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells incubated for 120 mins at 37 degC by [14C]-AMG uptake assay

Eur J Med Chem 55: 32-8 (2012)


Article DOI: 10.1016/j.ejmech.2012.06.053
BindingDB Entry DOI: 10.7270/Q2S183K0
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/an/an/a 429n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...

J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50335143
PNG
(4-Chloro-3-[4-(methylsulfanyl)benzyl]-1-(beta-D-xy...)
Show SMILES CSc1ccc(Cc2cn([C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)c3cccc(Cl)c23)cc1 |r|
Show InChI InChI=1S/C21H22ClNO4S/c1-28-14-7-5-12(6-8-14)9-13-10-23(16-4-2-3-15(22)18(13)16)21-20(26)19(25)17(24)11-27-21/h2-8,10,17,19-21,24-26H,9,11H2,1H3/t17-,19+,20-,21-/m1/s1
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n/an/an/an/a 462n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...

J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50335145
PNG
(4-Chloro-3-(4-cyclopropylbenzyl)-1-(beta-D-xylopyr...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12 |r|
Show InChI InChI=1S/C23H24ClNO4/c24-17-2-1-3-18-20(17)16(10-13-4-6-14(7-5-13)15-8-9-15)11-25(18)23-22(28)21(27)19(26)12-29-23/h1-7,11,15,19,21-23,26-28H,8-10,12H2/t19-,21+,22-,23-/m1/s1
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n/an/an/an/a 488n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method

Bioorg Med Chem 24: 2242-50 (2016)


Article DOI: 10.1016/j.bmc.2016.03.058
BindingDB Entry DOI: 10.7270/Q25D8TQP
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50389353
PNG
(CHEMBL2064098)
Show SMILES COc1ccc(Cn2cc([C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)c3cccc(F)c23)cc1 |r|
Show InChI InChI=1S/C21H22FNO5/c1-27-13-7-5-12(6-8-13)9-23-10-15(14-3-2-4-16(22)18(14)23)21-20(26)19(25)17(24)11-28-21/h2-8,10,17,19-21,24-26H,9,11H2,1H3/t17-,19+,20-,21+/m1/s1
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n/an/an/an/a 550n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells incubated for 120 mins at 37 degC by [14C]-AMG uptake assay

Eur J Med Chem 55: 32-8 (2012)


Article DOI: 10.1016/j.ejmech.2012.06.053
BindingDB Entry DOI: 10.7270/Q2S183K0
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/an/an/a 593n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells incubated for 120 mins at 37 degC by [14C]-AMG uptake assay

Eur J Med Chem 55: 32-8 (2012)


Article DOI: 10.1016/j.ejmech.2012.06.053
BindingDB Entry DOI: 10.7270/Q2S183K0
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50335144
PNG
(4-Chloro-3-[4-(N,N-dimethylamino)benzyl]-1-(beta-D...)
Show SMILES CN(C)c1ccc(Cc2cn([C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)c3cccc(Cl)c23)cc1 |r|
Show InChI InChI=1S/C22H25ClN2O4/c1-24(2)15-8-6-13(7-9-15)10-14-11-25(17-5-3-4-16(23)19(14)17)22-21(28)20(27)18(26)12-29-22/h3-9,11,18,20-22,26-28H,10,12H2,1-2H3/t18-,20+,21-,22-/m1/s1
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n/an/an/an/a 629n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...

J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50161661
PNG
(CHEMBL3787475)
Show SMILES CCOC(=O)CNC(=S)NC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12 |r|
Show InChI InChI=1S/C29H34ClN3O6S/c1-2-38-23(34)14-32-29(40)31-13-22-25(35)26(36)27(37)28(39-22)33-15-19(24-20(30)4-3-5-21(24)33)12-16-6-8-17(9-7-16)18-10-11-18/h3-9,15,18,22,25-28,35-37H,2,10-14H2,1H3,(H2,31,32,40)/t22-,25-,26+,27-,28-/m1/s1
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n/an/an/an/a 845n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method

Bioorg Med Chem 24: 2242-50 (2016)


Article DOI: 10.1016/j.bmc.2016.03.058
BindingDB Entry DOI: 10.7270/Q25D8TQP
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/an/an/a 860n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting method

Eur J Med Chem 143: 611-620 (2018)


Article DOI: 10.1016/j.ejmech.2017.11.019
BindingDB Entry DOI: 10.7270/Q2MK6GFZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50161716
PNG
(CHEMBL3785254)
Show SMILES O[C@@H]1[C@@H](CNC(=O)NCCCCl)O[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12 |r|
Show InChI InChI=1S/C28H33Cl2N3O5/c29-11-2-12-31-28(37)32-14-22-24(34)25(35)26(36)27(38-22)33-15-19(23-20(30)3-1-4-21(23)33)13-16-5-7-17(8-6-16)18-9-10-18/h1,3-8,15,18,22,24-27,34-36H,2,9-14H2,(H2,31,32,37)/t22-,24-,25+,26-,27-/m1/s1
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n/an/an/an/a 874n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method

Bioorg Med Chem 24: 2242-50 (2016)


Article DOI: 10.1016/j.bmc.2016.03.058
BindingDB Entry DOI: 10.7270/Q25D8TQP
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50389349
PNG
(CHEMBL2064099)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)c1cn(Cc2ccc(cc2)C2CC2)c2ccccc12 |r|
Show InChI InChI=1S/C23H25NO4/c25-20-13-28-23(22(27)21(20)26)18-12-24(19-4-2-1-3-17(18)19)11-14-5-7-15(8-6-14)16-9-10-16/h1-8,12,16,20-23,25-27H,9-11,13H2/t20-,21+,22-,23+/m1/s1
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n/an/an/an/a 884n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells incubated for 120 mins at 37 degC by [14C]-AMG uptake assay

Eur J Med Chem 55: 32-8 (2012)


Article DOI: 10.1016/j.ejmech.2012.06.053
BindingDB Entry DOI: 10.7270/Q2S183K0
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50386885
PNG
(CANAGLIFLOZIN | CANAGLIFLOZIN HYDRATE | US10752604...)
Show SMILES Cc1ccc(cc1Cc1ccc(s1)-c1ccc(F)cc1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C24H25FO5S/c1-13-2-3-15(24-23(29)22(28)21(27)19(12-26)30-24)10-16(13)11-18-8-9-20(31-18)14-4-6-17(25)7-5-14/h2-10,19,21-24,26-29H,11-12H2,1H3/t19-,21-,22+,23-,24+/m1/s1
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n/an/an/an/a 910n/an/an/an/a



Terns Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of SGLT1 (unknown origin)

J Med Chem 63: 5031-5073 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01701
BindingDB Entry DOI: 10.7270/Q2DJ5JXG
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/an/an/a 1.39E+3n/an/a7.222



Bristol-Myers Squibb Company



Assay Description
Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...

J Med Chem 51: 1145-9 (2008)


Article DOI: 10.1021/jm701272q
BindingDB Entry DOI: 10.7270/Q2PN93X4
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/an/an/a 1.40E+3n/an/an/an/a



Terns Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of SGLT1 (unknown origin)

J Med Chem 63: 5031-5073 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01701
BindingDB Entry DOI: 10.7270/Q2DJ5JXG
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50161654
PNG
(CHEMBL3787515)
Show SMILES CC(=O)NC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12 |r|
Show InChI InChI=1S/C12H23NO7/c14-4-2-1-3-9(16)13-5-7-10(17)12(19)11(18)8(6-15)20-7/h7-8,10-12,14-15,17-19H,1-6H2,(H,13,16)
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n/an/an/an/a 1.41E+3n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method

Bioorg Med Chem 24: 2242-50 (2016)


Article DOI: 10.1016/j.bmc.2016.03.058
BindingDB Entry DOI: 10.7270/Q25D8TQP
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50161656
PNG
(CHEMBL3786435)
Show SMILES COC(=O)c1cn(C[C@H]2O[C@H]([C@H](O)[C@@H](O)[C@@H]2O)n2cc(Cc3ccc(cc3)C3CC3)c3c(Cl)cccc23)nn1 |r|
Show InChI InChI=1S/C28H29ClN4O6/c1-38-28(37)20-13-32(31-30-20)14-22-24(34)25(35)26(36)27(39-22)33-12-18(23-19(29)3-2-4-21(23)33)11-15-5-7-16(8-6-15)17-9-10-17/h2-8,12-13,17,22,24-27,34-36H,9-11,14H2,1H3/t22-,24-,25+,26-,27-/m1/s1
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n/an/an/an/a 1.86E+3n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method

Bioorg Med Chem 24: 2242-50 (2016)


Article DOI: 10.1016/j.bmc.2016.03.058
BindingDB Entry DOI: 10.7270/Q25D8TQP
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50381554
PNG
(CHEMBL2018096)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(F)c(Cc2cc3ccccc3s2)c1 |r|
Show InChI InChI=1S/C21H21FO5S/c22-15-6-5-12(21-20(26)19(25)18(24)16(10-23)27-21)7-13(15)9-14-8-11-3-1-2-4-17(11)28-14/h1-8,16,18-21,23-26H,9-10H2/t16-,18-,19+,20-,21+/m1/s1
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n/an/an/an/a 1.90E+3n/an/an/an/a



Terns Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of SGLT1 (unknown origin)

J Med Chem 63: 5031-5073 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01701
BindingDB Entry DOI: 10.7270/Q2DJ5JXG
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50161655
PNG
(CHEMBL3785403)
Show SMILES NC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12 |r|
Show InChI InChI=1S/C24H27ClN2O4/c25-17-2-1-3-18-20(17)16(10-13-4-6-14(7-5-13)15-8-9-15)12-27(18)24-23(30)22(29)21(28)19(11-26)31-24/h1-7,12,15,19,21-24,28-30H,8-11,26H2/t19-,21-,22+,23-,24-/m1/s1
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n/an/an/an/a 2.03E+3n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method

Bioorg Med Chem 24: 2242-50 (2016)


Article DOI: 10.1016/j.bmc.2016.03.058
BindingDB Entry DOI: 10.7270/Q25D8TQP
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50389345
PNG
(CHEMBL2064095)
Show SMILES COc1ccc(Cn2cc([C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)c3ccccc23)cc1 |r|
Show InChI InChI=1S/C21H23NO5/c1-26-14-8-6-13(7-9-14)10-22-11-16(15-4-2-3-5-17(15)22)21-20(25)19(24)18(23)12-27-21/h2-9,11,18-21,23-25H,10,12H2,1H3/t18-,19+,20-,21+/m1/s1
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n/an/an/an/a 2.49E+3n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells incubated for 120 mins at 37 degC by [14C]-AMG uptake assay

Eur J Med Chem 55: 32-8 (2012)


Article DOI: 10.1016/j.ejmech.2012.06.053
BindingDB Entry DOI: 10.7270/Q2S183K0
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50161652
PNG
(CHEMBL3785293)
Show SMILES O[C@@H]1[C@@H](CNC(=O)CCl)O[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12 |r|
Show InChI InChI=1S/C26H28Cl2N2O5/c27-11-21(31)29-12-20-23(32)24(33)25(34)26(35-20)30-13-17(22-18(28)2-1-3-19(22)30)10-14-4-6-15(7-5-14)16-8-9-16/h1-7,13,16,20,23-26,32-34H,8-12H2,(H,29,31)/t20-,23-,24+,25-,26-/m1/s1
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n/an/an/an/a 3.05E+3n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method

Bioorg Med Chem 24: 2242-50 (2016)


Article DOI: 10.1016/j.bmc.2016.03.058
BindingDB Entry DOI: 10.7270/Q25D8TQP
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50389352
PNG
(CHEMBL2064102)
Show SMILES CCCc1ccc(Cn2cc([C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)c3ccccc23)cc1 |r|
Show InChI InChI=1S/C23H27NO4/c1-2-5-15-8-10-16(11-9-15)12-24-13-18(17-6-3-4-7-19(17)24)23-22(27)21(26)20(25)14-28-23/h3-4,6-11,13,20-23,25-27H,2,5,12,14H2,1H3/t20-,21+,22-,23+/m1/s1
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n/an/an/an/a 3.21E+3n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells incubated for 120 mins at 37 degC by [14C]-AMG uptake assay

Eur J Med Chem 55: 32-8 (2012)


Article DOI: 10.1016/j.ejmech.2012.06.053
BindingDB Entry DOI: 10.7270/Q2S183K0
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50285390
PNG
(CHEMBL4176765)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](\C=N\O)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r|
Show InChI InChI=1S/C21H24ClNO6/c1-2-28-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(29-21)11-23-27/h3-8,10-11,17-21,24-27H,2,9H2,1H3/b23-11+/t17-,18-,19+,20-,21+/m1/s1
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n/an/an/an/a 3.58E+3n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting method

Eur J Med Chem 143: 611-620 (2018)


Article DOI: 10.1016/j.ejmech.2017.11.019
BindingDB Entry DOI: 10.7270/Q2MK6GFZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50161720
PNG
(CHEMBL3787651)
Show SMILES CCOC(=O)CC(=O)NC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12 |r|
Show InChI InChI=1S/C29H33ClN2O7/c1-2-38-24(34)13-23(33)31-14-22-26(35)27(36)28(37)29(39-22)32-15-19(25-20(30)4-3-5-21(25)32)12-16-6-8-17(9-7-16)18-10-11-18/h3-9,15,18,22,26-29,35-37H,2,10-14H2,1H3,(H,31,33)/t22-,26-,27+,28-,29-/m1/s1
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n/an/an/an/a 3.81E+3n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method

Bioorg Med Chem 24: 2242-50 (2016)


Article DOI: 10.1016/j.bmc.2016.03.058
BindingDB Entry DOI: 10.7270/Q25D8TQP
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50315426
PNG
((1S)-1,5-Anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4...)
Show SMILES CCOc1ccc(Cc2cc([C@@H]3S[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c(OC)cc2C)cc1 |r|
Show InChI InChI=1S/C23H30O6S/c1-4-29-16-7-5-14(6-8-16)10-15-11-17(18(28-3)9-13(15)2)23-22(27)21(26)20(25)19(12-24)30-23/h5-9,11,19-27H,4,10,12H2,1-3H3/t19-,20-,21+,22-,23+/m1/s1
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n/an/an/an/a 4.00E+3n/an/an/an/a



Terns Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of SGLT1 (unknown origin)

J Med Chem 63: 5031-5073 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01701
BindingDB Entry DOI: 10.7270/Q2DJ5JXG
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50285394
PNG
(CHEMBL4168847)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](\C=N\NC(=O)c3ccc(Cl)cc3)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r|
Show InChI InChI=1S/C28H28Cl2N2O6/c1-2-37-21-10-3-16(4-11-21)13-19-14-18(7-12-22(19)30)27-26(35)25(34)24(33)23(38-27)15-31-32-28(36)17-5-8-20(29)9-6-17/h3-12,14-15,23-27,33-35H,2,13H2,1H3,(H,32,36)/b31-15+/t23-,24-,25+,26-,27+/m1/s1
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n/an/an/an/a 4.09E+3n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting method

Eur J Med Chem 143: 611-620 (2018)


Article DOI: 10.1016/j.ejmech.2017.11.019
BindingDB Entry DOI: 10.7270/Q2MK6GFZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50161722
PNG
(CHEMBL3785234)
Show SMILES CCOC(=O)C(=O)NC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12 |r|
Show InChI InChI=1S/C28H31ClN2O7/c1-2-37-28(36)26(35)30-13-21-23(32)24(33)25(34)27(38-21)31-14-18(22-19(29)4-3-5-20(22)31)12-15-6-8-16(9-7-15)17-10-11-17/h3-9,14,17,21,23-25,27,32-34H,2,10-13H2,1H3,(H,30,35)/t21-,23-,24+,25-,27-/m1/s1
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n/an/an/an/a 4.69E+3n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method

Bioorg Med Chem 24: 2242-50 (2016)


Article DOI: 10.1016/j.bmc.2016.03.058
BindingDB Entry DOI: 10.7270/Q25D8TQP
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50285391
PNG
(CHEMBL4164934)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](\C=N\NCc3ccccc3)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r|
Show InChI InChI=1S/C28H31ClN2O5/c1-2-35-22-11-8-18(9-12-22)14-21-15-20(10-13-23(21)29)28-27(34)26(33)25(32)24(36-28)17-31-30-16-19-6-4-3-5-7-19/h3-13,15,17,24-28,30,32-34H,2,14,16H2,1H3/b31-17+/t24-,25-,26+,27-,28+/m1/s1
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n/an/an/an/a 4.93E+3n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting method

Eur J Med Chem 143: 611-620 (2018)


Article DOI: 10.1016/j.ejmech.2017.11.019
BindingDB Entry DOI: 10.7270/Q2MK6GFZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50389347
PNG
(CHEMBL2064096)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)c1cn(Cc2ccc3ccccc3c2)c2ccccc12 |r|
Show InChI InChI=1S/C24H23NO4/c26-21-14-29-24(23(28)22(21)27)19-13-25(20-8-4-3-7-18(19)20)12-15-9-10-16-5-1-2-6-17(16)11-15/h1-11,13,21-24,26-28H,12,14H2/t21-,22+,23-,24+/m1/s1
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n/an/an/an/a 4.96E+3n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells incubated for 120 mins at 37 degC by [14C]-AMG uptake assay

Eur J Med Chem 55: 32-8 (2012)


Article DOI: 10.1016/j.ejmech.2012.06.053
BindingDB Entry DOI: 10.7270/Q2S183K0
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50285402
PNG
(CHEMBL4173627)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CNOC)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r|
Show InChI InChI=1S/C22H28ClNO6/c1-3-29-16-7-4-13(5-8-16)10-15-11-14(6-9-17(15)23)22-21(27)20(26)19(25)18(30-22)12-24-28-2/h4-9,11,18-22,24-27H,3,10,12H2,1-2H3/t18-,19-,20+,21-,22+/m1/s1
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n/an/an/an/a 5.39E+3n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting method

Eur J Med Chem 143: 611-620 (2018)


Article DOI: 10.1016/j.ejmech.2017.11.019
BindingDB Entry DOI: 10.7270/Q2MK6GFZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50161721
PNG
(CHEMBL3787068)
Show SMILES COC(=O)CC(=O)NC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12 |r|
Show InChI InChI=1S/C28H31ClN2O7/c1-37-23(33)12-22(32)30-13-21-25(34)26(35)27(36)28(38-21)31-14-18(24-19(29)3-2-4-20(24)31)11-15-5-7-16(8-6-15)17-9-10-17/h2-8,14,17,21,25-28,34-36H,9-13H2,1H3,(H,30,32)/t21-,25-,26+,27-,28-/m1/s1
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n/an/an/an/a 5.42E+3n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method

Bioorg Med Chem 24: 2242-50 (2016)


Article DOI: 10.1016/j.bmc.2016.03.058
BindingDB Entry DOI: 10.7270/Q25D8TQP
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50161493
PNG
(CHEMBL3786347)
Show SMILES COC(=O)C(=O)NC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12 |r|
Show InChI InChI=1S/C27H29ClN2O7/c1-36-27(35)25(34)29-12-20-22(31)23(32)24(33)26(37-20)30-13-17(21-18(28)3-2-4-19(21)30)11-14-5-7-15(8-6-14)16-9-10-16/h2-8,13,16,20,22-24,26,31-33H,9-12H2,1H3,(H,29,34)/t20-,22-,23+,24-,26-/m1/s1
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n/an/an/an/a 5.76E+3n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method

Bioorg Med Chem 24: 2242-50 (2016)


Article DOI: 10.1016/j.bmc.2016.03.058
BindingDB Entry DOI: 10.7270/Q25D8TQP
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50285401
PNG
(CHEMBL4166140)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](\C=N\OC)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r|
Show InChI InChI=1S/C22H26ClNO6/c1-3-29-16-7-4-13(5-8-16)10-15-11-14(6-9-17(15)23)22-21(27)20(26)19(25)18(30-22)12-24-28-2/h4-9,11-12,18-22,25-27H,3,10H2,1-2H3/b24-12+/t18-,19-,20+,21-,22+/m1/s1
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n/an/an/an/a 5.93E+3n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting method

Eur J Med Chem 143: 611-620 (2018)


Article DOI: 10.1016/j.ejmech.2017.11.019
BindingDB Entry DOI: 10.7270/Q2MK6GFZ
More data for this
Ligand-Target Pair
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