Found 56 hits of ic50 for UniProtKB: P18825 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50001922
(2-Naphthalen-1-ylmethyl-4,5-dihydro-1H-imidazole; ...)Show InChI InChI=1S/C14H14N2/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14/h1-7H,8-10H2,(H,15,16) | PDB
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CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem
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| DrugBank PubMed
| n/a | n/a | 0.00110 | n/a | n/a | n/a | n/a | n/a | n/a |
Ohio State University
Curated by ChEMBL
| Assay Description Compound was evaluated for Adrenergic activity against Alpha-2 adrenergic receptor in human platelets |
J Med Chem 35: 750-5 (1992)
BindingDB Entry DOI: 10.7270/Q27H1MTJ |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50230389
(CHEMBL541105)Show InChI InChI=1S/C15H14N2.ClH/c1-11(15-9-16-10-17-15)13-8-4-6-12-5-2-3-7-14(12)13;/h2-11H,1H3,(H,16,17);1H | PDB
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UniProtKB/SwissProt
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| PubMed
| n/a | n/a | 0.00340 | n/a | n/a | n/a | n/a | n/a | n/a |
Ohio State University
Curated by ChEMBL
| Assay Description Compound was tested for Adrenergic activity against Alpha-2 adrenergic receptor from rat aorta |
J Med Chem 35: 750-5 (1992)
BindingDB Entry DOI: 10.7270/Q27H1MTJ |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50230393
(CHEMBL553231)Show InChI InChI=1S/C15H16N2.ClH/c1-11(15-16-9-10-17-15)13-8-4-6-12-5-2-3-7-14(12)13;/h2-8,11H,9-10H2,1H3,(H,16,17);1H | PDB
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UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.0140 | n/a | n/a | n/a | n/a | n/a | n/a |
Ohio State University
Curated by ChEMBL
| Assay Description Compound was evaluated for Adrenergic activity against Alpha-2 adrenergic receptor in human platelets |
J Med Chem 35: 750-5 (1992)
BindingDB Entry DOI: 10.7270/Q27H1MTJ |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50230395
(CHEMBL557985)Show InChI InChI=1S/C15H16N2.ClH/c1-11(15-16-8-9-17-15)13-7-6-12-4-2-3-5-14(12)10-13;/h2-7,10-11H,8-9H2,1H3,(H,16,17);1H | PDB
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UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 0.0160 | n/a | n/a | n/a | n/a | n/a | n/a |
Ohio State University
Curated by ChEMBL
| Assay Description Compound was evaluated for Adrenergic activity against Alpha-2 adrenergic receptor in human platelets |
J Med Chem 35: 750-5 (1992)
BindingDB Entry DOI: 10.7270/Q27H1MTJ |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50230388
(CHEMBL537830)Show InChI InChI=1S/C14H12N2/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14/h1-9H,10H2,(H,15,16) | PDB
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| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.0340 | n/a | n/a | n/a | n/a | n/a | n/a |
Ohio State University
Curated by ChEMBL
| Assay Description Compound was evaluated for Adrenergic activity against Alpha-2 adrenergic receptor in human platelets |
J Med Chem 35: 750-5 (1992)
BindingDB Entry DOI: 10.7270/Q27H1MTJ |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50230394
(CHEMBL538801)Show InChI InChI=1S/C15H14N2.ClH/c1-11(15-9-16-10-17-15)13-7-6-12-4-2-3-5-14(12)8-13;/h2-11H,1H3,(H,16,17);1H | PDB
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UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a |
Ohio State University
Curated by ChEMBL
| Assay Description Compound was evaluated for Adrenergic activity against Alpha-2 adrenergic receptor in human platelets |
J Med Chem 35: 750-5 (1992)
BindingDB Entry DOI: 10.7270/Q27H1MTJ |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50230392
(CHEMBL554581)Show InChI InChI=1S/C15H14N2.ClH/c1-11(15-16-9-10-17-15)13-8-4-6-12-5-2-3-7-14(12)13;/h2-11H,1H3,(H,16,17);1H | PDB
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UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a |
Ohio State University
Curated by ChEMBL
| Assay Description Compound was evaluated for Adrenergic activity against Alpha-2 adrenergic receptor in human platelets |
J Med Chem 35: 750-5 (1992)
BindingDB Entry DOI: 10.7270/Q27H1MTJ |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50230391
(CHEMBL164540)Show InChI InChI=1S/C15H14N2.C2H2O4/c1-11(15-16-8-9-17-15)13-7-6-12-4-2-3-5-14(12)10-13;3-1(4)2(5)6/h2-11H,1H3,(H,16,17);(H,3,4)(H,5,6) | PDB
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| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 0.610 | n/a | n/a | n/a | n/a | n/a | n/a |
Ohio State University
Curated by ChEMBL
| Assay Description Compound was evaluated for Adrenergic activity against Alpha-2 adrenergic receptor in human platelets |
J Med Chem 35: 750-5 (1992)
BindingDB Entry DOI: 10.7270/Q27H1MTJ |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50021809
((2,6-Dichloro-4-iodo-phenyl)-(4,5-dihydro-1H-imida...)Show SMILES Clc1cc(I)cc(Cl)c1\[#7]=[#6]-1\[#7]-[#6]-[#6]-[#7]-1 Show InChI InChI=1S/C9H8Cl2IN3/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9/h3-4H,1-2H2,(H2,13,14,15) | PDB
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| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]p-aminoclonidine (PAC) binding to alpha-2 adrenergic receptor of purified human platelet plasma membranes |
J Med Chem 30: 1241-4 (1987)
BindingDB Entry DOI: 10.7270/Q2JM2CWR |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM34572
(BRIMONIDINE | CHEMBL844 | MLS000069370 | SMR000058...)Show InChI InChI=1S/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17) | PDB
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| DrugBank PDB PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]p-aminoclonidine (PAC) binding to alpha-2 adrenergic receptor of purified human platelet plasma membranes |
J Med Chem 30: 1241-4 (1987)
BindingDB Entry DOI: 10.7270/Q2JM2CWR |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50021812
(2,6-Dichloro-N-imidazolidin-2-ylidene-benzene-1,4-...)Show SMILES [#7]-c1cc(Cl)c(\[#7]=[#6]-2\[#7]-[#6]-[#6]-[#7]-2)c(Cl)c1 Show InChI InChI=1S/C9H10Cl2N4/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9/h3-4H,1-2,12H2,(H2,13,14,15) | PDB
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| CHEMBL PC cid PC sid UniChem
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Similars
| PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]p-aminoclonidine (PAC) binding to alpha-2 adrenergic receptor of purified human platelet plasma membranes |
J Med Chem 30: 1241-4 (1987)
BindingDB Entry DOI: 10.7270/Q2JM2CWR |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50013515
((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)Show SMILES COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 |r| Show InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1 | PDB
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| DrugBank PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]p-aminoclonidine (PAC) binding to alpha-2 adrenergic receptor of purified human platelet plasma membranes |
J Med Chem 30: 1241-4 (1987)
BindingDB Entry DOI: 10.7270/Q2JM2CWR |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50029050
((-)-(R)-epinephrine | (-)-3,4-dihydroxy-alpha-((me...)Show InChI InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1 | PDB
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| DrugBank PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]p-aminoclonidine (PAC) binding to alpha-2 adrenergic receptor of purified human platelet plasma membranes |
J Med Chem 30: 1241-4 (1987)
BindingDB Entry DOI: 10.7270/Q2JM2CWR |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50225285
(CHEBI:3757 | Catapres | Catapres-Tts-1 | Catapres-...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
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MCE PC cid PC sid UniChem
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| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]p-aminoclonidine (PAC) binding to alpha-2 adrenergic receptor of purified human platelet plasma membranes |
J Med Chem 30: 1241-4 (1987)
BindingDB Entry DOI: 10.7270/Q2JM2CWR |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50013515
((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)Show SMILES COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 |r| Show InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1 | PDB
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| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound was evaluated for the displacement of [3H]yohimbine in acetonitrile/acetic acid anti-corynanthine MIPs for Alpha-2 adrenergic receptor |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2WQ05ZJ |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50151930
(3-[4-(4-Benzo[1,3]dioxol-5-yl-piperazin-1-yl)-buty...)Show SMILES NC(=O)c1ccc2[nH]cc(CCCCN3CCN(CC3)c3ccc4OCOc4c3)c2c1 Show InChI InChI=1S/C24H28N4O3/c25-24(29)17-4-6-21-20(13-17)18(15-26-21)3-1-2-8-27-9-11-28(12-10-27)19-5-7-22-23(14-19)31-16-30-22/h4-7,13-15,26H,1-3,8-12,16H2,(H2,25,29) | PDB
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| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck KGaA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against Factor Xa |
J Med Chem 47: 4677-83 (2004)
Article DOI: 10.1021/jm040792y BindingDB Entry DOI: 10.7270/Q28S4PCR |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50228238
(CHEMBL30911)Show SMILES CO\C(O)=C1\C(C(C(=O)OCCN(C)CC2COc3ccccc3O2)=C(C)N=C1C)c1ccccc1[N+]([O-])=O |c:29,t:26| Show InChI InChI=1S/C28H31N3O8/c1-17-24(27(32)36-4)26(20-9-5-6-10-21(20)31(34)35)25(18(2)29-17)28(33)37-14-13-30(3)15-19-16-38-22-11-7-8-12-23(22)39-19/h5-12,19,26,32H,13-16H2,1-4H3/b27-24+ | PDB
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| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Pharmacologie (UA 589 CNRS)
Curated by ChEMBL
| Assay Description In vitro ability to inhibit norepinephrine binding to alpha-2 adrenergic receptor of guinea pig vas deferens |
J Med Chem 32: 1402-7 (1989)
BindingDB Entry DOI: 10.7270/Q2SQ92M9 |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50228237
(CHEMBL554455)Show SMILES Cl.CO\C(O)=C1\C(C(C(=O)OCCN(C)CC2COc3ccccc3O2)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |c:29,t:26| Show InChI InChI=1S/C28H31N3O8.ClH/c1-17-24(27(32)36-4)26(19-8-7-9-20(14-19)31(34)35)25(18(2)29-17)28(33)37-13-12-30(3)15-21-16-38-22-10-5-6-11-23(22)39-21;/h5-11,14,21,26,32H,12-13,15-16H2,1-4H3;1H/b27-24+; | PDB
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| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Pharmacologie (UA 589 CNRS)
Curated by ChEMBL
| Assay Description In vitro ability to inhibit norepinephrine binding to alpha-2 adrenergic receptor of guinea pig vas deferens |
J Med Chem 32: 1402-7 (1989)
BindingDB Entry DOI: 10.7270/Q2SQ92M9 |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50005127
(1,1-Dioxo-2-[4-(4-pyrimidin-2-yl-piperazin-1-yl)-b...)Show SMILES O=C1N(CCCCN2CCN(CC2)c2ncccn2)S(=O)(=O)c2ccccc12 Show InChI InChI=1S/C19H23N5O3S/c25-18-16-6-1-2-7-17(16)28(26,27)24(18)11-4-3-10-22-12-14-23(15-13-22)19-20-8-5-9-21-19/h1-2,5-9H,3-4,10-15H2 | PDB
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| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck KGaA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against Factor Xa |
J Med Chem 47: 4677-83 (2004)
Article DOI: 10.1021/jm040792y BindingDB Entry DOI: 10.7270/Q28S4PCR |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50228241
(CHEMBL540511)Show SMILES Cl.CC(C)O\C(O)=C1\C(C(C(=O)OCCN(C)CC2COc3ccccc3O2)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |c:31,t:28| Show InChI InChI=1S/C30H35N3O8.ClH/c1-18(2)40-30(35)27-20(4)31-19(3)26(28(27)21-9-8-10-22(15-21)33(36)37)29(34)38-14-13-32(5)16-23-17-39-24-11-6-7-12-25(24)41-23;/h6-12,15,18,23,28,35H,13-14,16-17H2,1-5H3;1H/b30-27+; | PDB
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| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Pharmacologie (UA 589 CNRS)
Curated by ChEMBL
| Assay Description Alpha-2-adrenolytic activity was assessed in vitro from the ability to inhibit norepinephrine binding to guinea pig vas deferens |
J Med Chem 32: 1402-7 (1989)
BindingDB Entry DOI: 10.7270/Q2SQ92M9 |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50013515
((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)Show SMILES COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 |r| Show InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1 | PDB
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| DrugBank
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | 5.0 | n/a |
TBA
| Assay Description Alpha-2 adrenergic receptor binding activity was determined by displacement of [3H]yohimbine in 50 mM phosphate buffer pH 5.0/Tween 20 where the poly... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2WQ05ZJ |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50151946
(3-{4-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)Show SMILES COc1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C(N)=O)CC1 Show InChI InChI=1S/C24H30N4O2/c1-30-21-8-6-20(7-9-21)28-14-12-27(13-15-28)11-3-2-4-19-17-26-23-10-5-18(24(25)29)16-22(19)23/h5-10,16-17,26H,2-4,11-15H2,1H3,(H2,25,29) | PDB
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| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck KGaA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against Factor Xa |
J Med Chem 47: 4677-83 (2004)
Article DOI: 10.1021/jm040792y BindingDB Entry DOI: 10.7270/Q28S4PCR |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50226861
(CHEMBL22073)Show InChI InChI=1S/C13H16Cl2N6/c14-10-7-9(19-20-21-5-1-2-6-21)8-11(15)12(10)18-13-16-3-4-17-13/h7-8H,1-6H2,(H2,16,17,18)/b20-19+ | PDB
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| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]p-aminoclonidine (PAC) binding to alpha-2 adrenergic receptor of purified human platelet plasma membranes |
J Med Chem 30: 1241-4 (1987)
BindingDB Entry DOI: 10.7270/Q2JM2CWR |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50036913
((+-)-4-(alpha,2,3-trimethylbenzyl)imidazole | 4-[1...)Show InChI InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15) | PDB
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| n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ohio State University
Curated by ChEMBL
| Assay Description Alpha-2 adrenergic receptor antagonistic activity in human blood platelets. |
J Med Chem 39: 3001-13 (1996)
Article DOI: 10.1021/jm9506074 BindingDB Entry DOI: 10.7270/Q2BV7KBH |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50230390
(CHEBI:48556 | MEDETOMIDINE HYDROCHLORIDE | MPV-785...)Show InChI InChI=1S/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H | PDB
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| n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ohio State University
Curated by ChEMBL
| Assay Description Compound was evaluated for Adrenergic activity in Alpha-2 adrenergic receptor of human platelets |
J Med Chem 35: 750-5 (1992)
BindingDB Entry DOI: 10.7270/Q27H1MTJ |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50036910
(4-(1-Naphthalen-1-yl-ethyl)-1H-imidazole | CHEMBL3...)Show InChI InChI=1S/C15H14N2/c1-11(15-9-16-10-17-15)13-8-4-6-12-5-2-3-7-14(12)13/h2-11H,1H3,(H,16,17) | PDB
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| n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ohio State University
Curated by ChEMBL
| Assay Description Antagonistic activity against Alpha-2 adrenergic receptor in human blood platelets |
J Med Chem 39: 3001-13 (1996)
Article DOI: 10.1021/jm9506074 BindingDB Entry DOI: 10.7270/Q2BV7KBH |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50005836
(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)Show SMILES COC1CN(CCCOc2ccc(F)cc2)CCC1NC(=O)c1cc(Cl)c(N)cc1OC Show InChI InChI=1S/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29) | PDB
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| n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Binding affinity to adrenergic alpha-2 receptor |
J Med Chem 49: 1125-39 (2006)
Article DOI: 10.1021/jm0509501 BindingDB Entry DOI: 10.7270/Q2W096Q0 |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50005836
(4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...)Show SMILES COC1CN(CCCOc2ccc(F)cc2)CCC1NC(=O)c1cc(Cl)c(N)cc1OC Show InChI InChI=1S/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29) | PDB
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| n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Concentration required for inhibition of alpha-2 adrenergic receptor |
Bioorg Med Chem Lett 14: 5509-12 (2004)
Article DOI: 10.1016/j.bmcl.2004.09.005 BindingDB Entry DOI: 10.7270/Q2NV9K0K |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50151982
(5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1...)Show SMILES NC(=O)c1cc2cc(ccc2o1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1 Show InChI InChI=1S/C26H27N5O2/c27-16-18-4-6-23-22(13-18)19(17-29-23)3-1-2-8-30-9-11-31(12-10-30)21-5-7-24-20(14-21)15-25(33-24)26(28)32/h4-7,13-15,17,29H,1-3,8-12H2,(H2,28,32) | PDB
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| n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck KGaA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against Factor Xa |
J Med Chem 47: 4684-92 (2004)
Article DOI: 10.1021/jm040793q BindingDB Entry DOI: 10.7270/Q2513XPS |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50151935
(5-Methoxy-3-{4-[4-(4-methoxy-phenyl)-piperazin-1-y...)Show SMILES COc1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(OC)cc23)CC1 Show InChI InChI=1S/C24H31N3O2/c1-28-21-8-6-20(7-9-21)27-15-13-26(14-16-27)12-4-3-5-19-18-25-24-11-10-22(29-2)17-23(19)24/h6-11,17-18,25H,3-5,12-16H2,1-2H3 | PDB
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| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck KGaA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against Factor Xa |
J Med Chem 47: 4677-83 (2004)
Article DOI: 10.1021/jm040792y BindingDB Entry DOI: 10.7270/Q28S4PCR |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50228239
(CHEMBL2093965)Show SMILES Cl.CO\C(O)=C1\[C@@H](C(C(=O)OCCN(C)C[C@@H]2COc3ccccc3O2)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |r,c:29,t:26| Show InChI InChI=1S/C28H31N3O8.ClH/c1-17-24(27(32)36-4)26(19-8-7-9-20(14-19)31(34)35)25(18(2)29-17)28(33)37-13-12-30(3)15-21-16-38-22-10-5-6-11-23(22)39-21;/h5-11,14,21,26,32H,12-13,15-16H2,1-4H3;1H/b27-24+;/t21-,26+;/m1./s1 | PDB
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| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Pharmacologie (UA 589 CNRS)
Curated by ChEMBL
| Assay Description Alpha-2-adrenolytic activity was assessed in vitro from the ability to inhibit norepinephrine binding to guinea pig vas deferens |
J Med Chem 32: 1402-7 (1989)
BindingDB Entry DOI: 10.7270/Q2SQ92M9 |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50181840
((1R,7aS)-hexahydro-1H-pyrrolizin-1-ylmethyl 1-Meth...)Show SMILES O=C(OC[C@@H]1CCN2CCC[C@@H]12)c1c[nH]c2ccccc12 Show InChI InChI=1S/C17H20N2O2/c20-17(14-10-18-15-5-2-1-4-13(14)15)21-11-12-7-9-19-8-3-6-16(12)19/h1-2,4-5,10,12,16,18H,3,6-9,11H2/t12-,16-/m0/s1 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Binding affinity to adrenergic alpha-2 receptor |
J Med Chem 49: 1125-39 (2006)
Article DOI: 10.1021/jm0509501 BindingDB Entry DOI: 10.7270/Q2W096Q0 |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50101815
(CHEBI:7550 | Nicardipine)Show SMILES COC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OCCN(C)Cc1ccccc1 |c:4,9| Show InChI InChI=1S/C26H29N3O6/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19/h5-12,15,24,27H,13-14,16H2,1-4H3 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Pharmacologie (UA 589 CNRS)
Curated by ChEMBL
| Assay Description Alpha-2-adrenolytic activity was assessed in vitro from the ability to inhibit norepinephrine binding to guinea pig vas deferens |
J Med Chem 32: 1402-7 (1989)
BindingDB Entry DOI: 10.7270/Q2SQ92M9 |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)Show SMILES COc1cc(ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1C Show InChI InChI=1S/C31H33N3O6S/c1-20-8-4-7-11-29(20)41(37,38)33-30(35)22-13-12-21(28(17-22)39-3)16-23-19-34(2)27-15-14-24(18-26(23)27)32-31(36)40-25-9-5-6-10-25/h4,7-8,11-15,17-19,25H,5-6,9-10,16H2,1-3H3,(H,32,36)(H,33,35) | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory concentration against Alpha-2 adrenergic receptor |
Bioorg Med Chem Lett 5: 1377-1382 (1995)
Article DOI: 10.1016/0960-894X(95)00227-K BindingDB Entry DOI: 10.7270/Q2M045D5 |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50181839
(CHEMBL202434 | N-exo-((4S,7alphaS)-tetrahydro-1H-p...)Show SMILES Clc1cc(C(=O)NC[C@@H]2CCN3CCC[C@@H]23)c2nccn2c1 Show InChI InChI=1S/C16H19ClN4O/c17-12-8-13(15-18-4-7-21(15)10-12)16(22)19-9-11-3-6-20-5-1-2-14(11)20/h4,7-8,10-11,14H,1-3,5-6,9H2,(H,19,22)/t11-,14-/m0/s1 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Binding affinity to adrenergic alpha-2 receptor |
J Med Chem 49: 1125-39 (2006)
Article DOI: 10.1021/jm0509501 BindingDB Entry DOI: 10.7270/Q2W096Q0 |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50284690
(1-(4-{3-[(E)-2-(5-Fluoro-benzothiazol-2-yl)-vinyl]...)Show SMILES Cc1nc2cnccc2n1-c1ccc(OCc2cccc(\C=C\c3nc4cc(F)ccc4s3)c2)cc1 Show InChI InChI=1S/C29H21FN4OS/c1-19-32-26-17-31-14-13-27(26)34(19)23-7-9-24(10-8-23)35-18-21-4-2-3-20(15-21)5-12-29-33-25-16-22(30)6-11-28(25)36-29/h2-17H,18H2,1H3/b12-5+ | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory concentration against Alpha-2 adrenergic receptor |
Bioorg Med Chem Lett 5: 1377-1382 (1995)
Article DOI: 10.1016/0960-894X(95)00227-K BindingDB Entry DOI: 10.7270/Q2M045D5 |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50284689
(7-Chloro-2-((E)-2-{3-[4-(2-methyl-imidazo[4,5-c]py...)Show SMILES Cc1nc2cnccc2n1-c1ccc(OCc2cccc(\C=C\c3ccc4ccc(Cl)cc4n3)c2)cc1 Show InChI InChI=1S/C31H23ClN4O/c1-21-34-30-19-33-16-15-31(30)36(21)27-11-13-28(14-12-27)37-20-23-4-2-3-22(17-23)5-9-26-10-7-24-6-8-25(32)18-29(24)35-26/h2-19H,20H2,1H3/b9-5+ | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory concentration against Alpha-2 adrenergic receptor |
Bioorg Med Chem Lett 5: 1377-1382 (1995)
Article DOI: 10.1016/0960-894X(95)00227-K BindingDB Entry DOI: 10.7270/Q2M045D5 |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50181836
(4-Amino-N-(1-aza-tricyclo[3.3.1.0*3,7*]non-4-yl)-5...)Show SMILES COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1C2CC3CN(CC13)C2 |r,TLB:12:13:16.15:18.19.21,15:14:19:16.17,THB:17:18:13:16.15,17:16:13:18.19.21,12:13:19:16.17,15:16:19:13.14.21| Show InChI InChI=1S/C16H20ClN3O2/c1-22-14-4-13(18)12(17)3-10(14)16(21)19-15-9-2-8-5-20(6-9)7-11(8)15/h3-4,8-9,11,15H,2,5-7,18H2,1H3,(H,19,21) | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Concentration required for inhibition of alpha-2 adrenergic receptor |
Bioorg Med Chem Lett 14: 5509-12 (2004)
Article DOI: 10.1016/j.bmcl.2004.09.005 BindingDB Entry DOI: 10.7270/Q2NV9K0K |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50181836
(4-Amino-N-(1-aza-tricyclo[3.3.1.0*3,7*]non-4-yl)-5...)Show SMILES COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1C2CC3CN(CC13)C2 |r,TLB:12:13:16.15:18.19.21,15:14:19:16.17,THB:17:18:13:16.15,17:16:13:18.19.21,12:13:19:16.17,15:16:19:13.14.21| Show InChI InChI=1S/C16H20ClN3O2/c1-22-14-4-13(18)12(17)3-10(14)16(21)19-15-9-2-8-5-20(6-9)7-11(8)15/h3-4,8-9,11,15H,2,5-7,18H2,1H3,(H,19,21) | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Binding affinity to adrenergic alpha-2 receptor |
J Med Chem 49: 1125-39 (2006)
Article DOI: 10.1021/jm0509501 BindingDB Entry DOI: 10.7270/Q2W096Q0 |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50155153
(4-Amino-N-(1-aza-tricyclo[3.3.1.1*3,7*]dec-4-ylmet...)Show SMILES COc1cc(N)c(Cl)cc1C(=O)NCC1C2CC3CC1CN(C3)C2 |TLB:14:15:19.20.18:22,13:14:20:17.18.22,THB:16:15:20:17.18.22,16:17:15.14.23:20,14:19:15.23.16:22,(-1.58,-4.14,;-1.58,-2.61,;-2.91,-1.83,;-4.24,-2.61,;-5.57,-1.83,;-6.92,-2.61,;-5.57,-.29,;-6.9,.48,;-4.24,.48,;-2.91,-.29,;-1.58,.49,;-1.59,2.04,;-.25,-.26,;1.08,.49,;2.43,-.26,;4.02,.44,;5.42,-.05,;6.33,1.04,;4.81,.48,;3.32,1.02,;3.25,2.53,;4.8,3.07,;6.26,2.56,;4.01,1.86,)| Show InChI InChI=1S/C18H24ClN3O2/c1-24-17-5-16(20)15(19)4-13(17)18(23)21-6-14-11-2-10-3-12(14)9-22(7-10)8-11/h4-5,10-12,14H,2-3,6-9,20H2,1H3,(H,21,23)/t10?,11?,12?,14- | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Concentration required for inhibition of alpha-2 adrenergic receptor |
Bioorg Med Chem Lett 14: 5509-12 (2004)
Article DOI: 10.1016/j.bmcl.2004.09.005 BindingDB Entry DOI: 10.7270/Q2NV9K0K |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50226860
(CHEMBL21734)Show SMILES [#8-]-[#7+](=O)-c1cc(Cl)c(\[#7]=[#6]-2/[#7]-[#6]-[#6]-[#7]-2)c(Cl)c1 Show InChI InChI=1S/C9H8Cl2N4O2/c10-6-3-5(15(16)17)4-7(11)8(6)14-9-12-1-2-13-9/h3-4H,1-2H2,(H2,12,13,14) | PDB
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UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
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| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]p-aminoclonidine (PAC) binding to alpha-2 adrenergic receptor of purified human platelet plasma membranes |
J Med Chem 30: 1241-4 (1987)
BindingDB Entry DOI: 10.7270/Q2JM2CWR |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50155152
(4-Amino-N-(1-aza-tricyclo[3.3.1.1*3,7*]dec-4-yl)-5...)Show SMILES COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CC1CN(C3)C2 |TLB:12:13:17:20.19.21,22:20:13.14.15:17,THB:21:20:13:16.15.17,21:16:13:20.19.22,22:14:17:20.19.21,(8.67,-11.69,;8.67,-10.15,;7.33,-9.38,;5.99,-10.15,;4.66,-9.38,;3.32,-10.15,;4.66,-7.83,;3.33,-7.06,;5.99,-7.05,;7.33,-7.82,;8.66,-7.05,;8.66,-5.5,;10.01,-7.81,;11.34,-7.04,;12.54,-5.76,;13.85,-6.25,;15.25,-5.9,;14.24,-7.18,;12.84,-6.62,;12.82,-5.01,;13.87,-3.79,;15.27,-4.37,;12.52,-4.26,)| Show InChI InChI=1S/C17H22ClN3O2/c1-23-15-5-14(19)13(18)4-12(15)17(22)20-16-10-2-9-3-11(16)8-21(6-9)7-10/h4-5,9-11,16H,2-3,6-8,19H2,1H3,(H,20,22)/t9?,10?,11?,16- | PDB
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UniProtKB/SwissProt
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Concentration required for inhibition of alpha-2 adrenergic receptor |
Bioorg Med Chem Lett 14: 5509-12 (2004)
Article DOI: 10.1016/j.bmcl.2004.09.005 BindingDB Entry DOI: 10.7270/Q2NV9K0K |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50005833
((exo)4-Amino-5-chloro-N-(hexahydro-pyrrolizin-1-yl...)Show SMILES COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CCN2CCC[C@@H]12 Show InChI InChI=1S/C16H22ClN3O2/c1-22-15-8-13(18)12(17)7-11(15)16(21)19-9-10-4-6-20-5-2-3-14(10)20/h7-8,10,14H,2-6,9,18H2,1H3,(H,19,21)/t10-,14-/m0/s1 | PDB
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| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Binding affinity to adrenergic alpha-2 receptor |
J Med Chem 49: 1125-39 (2006)
Article DOI: 10.1021/jm0509501 BindingDB Entry DOI: 10.7270/Q2W096Q0 |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50181837
((1S,7aR)-hexahydro-1H-pyrrolizin-1-ylmethyl 1-meth...)Show SMILES Cn1nc(C(=O)OC[C@@H]2CCN3CCC[C@@H]23)c2ccccc12 Show InChI InChI=1S/C17H21N3O2/c1-19-15-6-3-2-5-13(15)16(18-19)17(21)22-11-12-8-10-20-9-4-7-14(12)20/h2-3,5-6,12,14H,4,7-11H2,1H3/t12-,14-/m0/s1 | PDB
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| CHEMBL PC cid PC sid UniChem
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| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Binding affinity to adrenergic alpha-2 receptor |
J Med Chem 49: 1125-39 (2006)
Article DOI: 10.1021/jm0509501 BindingDB Entry DOI: 10.7270/Q2W096Q0 |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50181841
((1S,7aR)-hexahydro-1H-pyrrolizin-1-ylmethyl 1H-ind...)Show SMILES O=C(OC[C@@H]1CCN2CCC[C@@H]12)c1[nH]nc2ccccc12 Show InChI InChI=1S/C16H19N3O2/c20-16(15-12-4-1-2-5-13(12)17-18-15)21-10-11-7-9-19-8-3-6-14(11)19/h1-2,4-5,11,14H,3,6-10H2,(H,17,18)/t11-,14-/m0/s1 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Binding affinity to adrenergic alpha-2 receptor |
J Med Chem 49: 1125-39 (2006)
Article DOI: 10.1021/jm0509501 BindingDB Entry DOI: 10.7270/Q2W096Q0 |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50470860
(CHEMBL105328)Show InChI InChI=1S/C16H14N2/c1-3-11-5-2-6-14-13(15-9-17-10-18-15)8-7-12(4-1)16(11)14/h1-6,9-10,13H,7-8H2,(H,17,18) | PDB
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UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.43E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Ohio State University
Curated by ChEMBL
| Assay Description Alpha-2 adrenergic receptor antagonistic activity in human blood platelets. |
J Med Chem 39: 3001-13 (1996)
Article DOI: 10.1021/jm9506074 BindingDB Entry DOI: 10.7270/Q2BV7KBH |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50470864
(CHEMBL420652)Show InChI InChI=1S/C17H16N2/c1-2-6-14-12(4-1)8-9-13-5-3-7-15(17(13)14)16-10-18-11-19-16/h1-2,4,6,8-11,15H,3,5,7H2,(H,18,19) | PDB
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UniProtKB/SwissProt
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| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9.77E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Ohio State University
Curated by ChEMBL
| Assay Description Alpha-2 adrenergic receptor antagonistic activity in human blood platelets. |
J Med Chem 39: 3001-13 (1996)
Article DOI: 10.1021/jm9506074 BindingDB Entry DOI: 10.7270/Q2BV7KBH |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50228236
(CHEMBL3350238)Show SMILES Cl.COC(=O)C1=C(C)NC(C)=C([C@@H]1c1cccc(c1)[N+]([O-])=O)C(=O)OCCN(C)C[C@H]1COc2ccccc2O1 |r,c:4,9| Show InChI InChI=1S/C28H31N3O8.ClH/c1-17-24(27(32)36-4)26(19-8-7-9-20(14-19)31(34)35)25(18(2)29-17)28(33)37-13-12-30(3)15-21-16-38-22-10-5-6-11-23(22)39-21;/h5-11,14,21,26,29H,12-13,15-16H2,1-4H3;1H/t21-,26+;/m0./s1 | PDB
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UniProtKB/SwissProt
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Pharmacologie (UA 589 CNRS)
Curated by ChEMBL
| Assay Description In vitro ability to inhibit norepinephrine binding to alpha-2 adrenergic receptor of guinea pig vas deferens |
J Med Chem 32: 1402-7 (1989)
BindingDB Entry DOI: 10.7270/Q2SQ92M9 |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50228235
(CHEMBL554235)Show SMILES Cl.CO\C(O)=C1\C(C(C(=O)OCCN(C)C(C2CCCCC2)c2ccccc2)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |c:31,t:28| Show InChI InChI=1S/C32H39N3O6.ClH/c1-21-27(31(36)40-4)29(25-16-11-17-26(20-25)35(38)39)28(22(2)33-21)32(37)41-19-18-34(3)30(23-12-7-5-8-13-23)24-14-9-6-10-15-24;/h5,7-8,11-13,16-17,20,24,29-30,36H,6,9-10,14-15,18-19H2,1-4H3;1H/b31-27+; | PDB
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UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Pharmacologie (UA 589 CNRS)
Curated by ChEMBL
| Assay Description In vitro ability to inhibit norepinephrine binding to alpha-2 adrenergic receptor of guinea pig vas deferens |
J Med Chem 32: 1402-7 (1989)
BindingDB Entry DOI: 10.7270/Q2SQ92M9 |
More data for this Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50013515
((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)Show SMILES COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 |r| Show InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1 | PDB
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| n/a | n/a | 1.95E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compound was evaluated for the displacement of [3H]yohimbine in acetonitrile/acetic acid where the polymer is anti-yohimbin MIPs for Alpha-2 adrenerg... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2WQ05ZJ |
More data for this Ligand-Target Pair | |