BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 530 hits of ic50 for UniProtKB: P25105   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50280478
PNG
(BB-823 | CHEMBL157078 | N-((S)-1-Ethoxymethyl-3-me...)
Show SMILES CCOC[C@H](CC(C)C)NS(=O)(=O)c1ccc(Cn2c(C)nc3cnccc23)cc1
Show InChI InChI=1S/C22H30N4O3S/c1-5-29-15-19(12-16(2)3)25-30(27,28)20-8-6-18(7-9-20)14-26-17(4)24-21-13-23-11-10-22(21)26/h6-11,13,16,19,25H,5,12,14-15H2,1-4H3/t19-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
n/an/a 0.0150n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.

Bioorg Med Chem Lett 2: 597-602 (1992)


Article DOI: 10.1016/S0960-894X(01)81205-1
BindingDB Entry DOI: 10.7270/Q2CF9QK7
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011635
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)CCc2ccccc12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C27H20ClN5OS/c1-17-30-31-24-16-29-26(20-9-3-4-10-22(20)28)21-15-19(35-27(21)33(17)24)8-6-14-32-23-11-5-2-7-18(23)12-13-25(32)34/h2-5,7,9-11,15H,12-14,16H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 0.200n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM85035
PNG
(CAS_65154-06-5 | PAF | bloodplatelet-activatingfac...)
Show SMILES CCCCCCCCCCCCCCCCOC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(C)=O |r|
Show InChI InChI=1S/C26H54NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5/h26H,6-24H2,1-5H3/t26-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

DrugBank
MCE
KEGG
PC cid
PC sid
PDB
UniChem

Patents

Similars
Article
PubMed
n/an/a 0.280n/an/an/an/an/an/a



Broad Institute of MIT and Harvard

Curated by ChEMBL


Assay Description
Displacement of [3H]PAF from platelet activating factor receptor in human platelets after 3 hrs

Bioorg Med Chem Lett 23: 1834-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.025
BindingDB Entry DOI: 10.7270/Q2P55PWC
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011650
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2ccccc2n(C)c1=O)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C26H19ClN6OS/c1-16-29-30-23-15-28-24(18-9-3-4-10-20(18)27)19-14-17(35-25(19)33(16)23)8-7-13-32-22-12-6-5-11-21(22)31(2)26(32)34/h3-6,9-12,14H,13,15H2,1-2H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 0.300n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552615
PNG
(WO2022101377, Example 14)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)NCc1ccc(cc1)C(F)(F)F)c1ccccc1Cl
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
WIPO WO2022101377
n/an/a 0.400n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552651
PNG
(WO2022101377, Example 50)
Show SMILES CCC12CC(C1)(C2)NC(=O)[C@@H]1Cc2sc-3c([C@@H](NCc4nnc(C)n-34)c3ccccc3Cl)c2C1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
WIPO WO2022101377
n/an/a 0.5n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011611
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2ccccc2c(=O)n(C)c1=O)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C27H19ClN6O2S/c1-16-30-31-23-15-29-24(18-9-3-5-11-21(18)28)20-14-17(37-26(20)34(16)23)8-7-13-33-22-12-6-4-10-19(22)25(35)32(2)27(33)36/h3-6,9-12,14H,13,15H2,1-2H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 0.600n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552674
PNG
(WO2022101377, Example 73)
Show SMILES CCCN(CCC)C(=O)[C@@H]1Cc2sc-3c([C@@H](NCc4nnc(C)n-34)c3ccccc3Cl)c2C1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
WIPO WO2022101377
n/an/a 0.700n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011623
PNG
(2a-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCC12CCCc3cccc(NC1=O)c23)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C29H22ClN5OS/c1-17-33-34-24-16-31-26(20-10-2-3-11-22(20)30)21-15-19(37-27(21)35(17)24)9-6-14-29-13-5-8-18-7-4-12-23(25(18)29)32-28(29)36/h2-4,7,10-12,15H,5,8,13-14,16H2,1H3,(H,32,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 0.700n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011634
PNG
(4-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)COc2ccccc12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C26H18ClN5O2S/c1-16-29-30-23-14-28-25(18-8-2-3-9-20(18)27)19-13-17(35-26(19)32(16)23)7-6-12-31-21-10-4-5-11-22(21)34-15-24(31)33/h2-5,8-11,13H,12,14-15H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 0.700n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011653
PNG
(2-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1ccc2ccccc2c1=O)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C27H18ClN5OS/c1-17-30-31-24-16-29-25(21-10-4-5-11-23(21)28)22-15-19(35-27(22)33(17)24)8-6-13-32-14-12-18-7-2-3-9-20(18)26(32)34/h2-5,7,9-12,14-15H,13,16H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 1n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011603
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2ccccc2n(-c2ccccc2)c1=O)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C31H21ClN6OS/c1-20-34-35-28-19-33-29(23-13-5-6-14-25(23)32)24-18-22(40-30(24)37(20)28)12-9-17-36-26-15-7-8-16-27(26)38(31(36)39)21-10-3-2-4-11-21/h2-8,10-11,13-16,18H,17,19H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 1n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50013923
PNG
(3-(1-Butyl-4-methoxy-naphthalen-2-yl)-N-(1-methyl-...)
Show SMILES CCCCc1c(\C=C\C(=O)N[C@@H](C)CCCc2cccnc2)cc(OC)c2ccccc12
Show InChI InChI=1S/C28H34N2O2/c1-4-5-13-24-23(19-27(32-3)26-15-7-6-14-25(24)26)16-17-28(31)30-21(2)10-8-11-22-12-9-18-29-20-22/h6-7,9,12,14-21H,4-5,8,10-11,13H2,1-3H3,(H,30,31)/b17-16+/t21-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to platelet activating factor receptor citrate-treated dog blood

J Med Chem 33: 2856-64 (1990)


BindingDB Entry DOI: 10.7270/Q21V5CZJ
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50280339
PNG
((S)-2-[4-(2-Benzenesulfonyl-ethoxy)-3-methoxy-5-(p...)
Show SMILES CCCS(=O)(=O)c1cc(cc(OC)c1OCCS(=O)(=O)c1ccccc1)C1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C31H38O10S2/c1-6-15-43(34,35)29-20-22(19-28(38-4)31(29)40-14-16-42(32,33)23-10-8-7-9-11-23)25-13-12-24(41-25)21-17-26(36-2)30(39-5)27(18-21)37-3/h7-11,17-20,24-25H,6,12-16H2,1-5H3/t24-,25?/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
n/an/a 1n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibitory activity of binding of [3H]-C18 PAF to human platelet membrane Platelet activating factor receptor

Bioorg Med Chem Lett 2: 181-184 (1992)


Article DOI: 10.1016/S0960-894X(01)80446-7
BindingDB Entry DOI: 10.7270/Q24X588Z
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011640
PNG
(4-(2-Chloro-phenyl)-2-(3-indazol-1-yl-prop-1-ynyl)...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1ncc2ccccc12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C25H17ClN6S/c1-16-29-30-23-15-27-24(19-9-3-4-10-21(19)26)20-13-18(33-25(20)32(16)23)8-6-12-31-22-11-5-2-7-17(22)14-28-31/h2-5,7,9-11,13-14H,12,15H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 1n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552632
PNG
(WO2022101377, Example 31)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)NCc1ccccc1)c1ccccc1Cl
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
WIPO WO2022101377
n/an/a 1.10n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552611
PNG
(WO2022101377, Example 10)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)NC1(CC1)c1ccc(Cl)cn1)c1ccccc1Cl
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
WIPO WO2022101377
n/an/a 1.30n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552624
PNG
(WO2022101377, Example 23)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
WIPO WO2022101377
n/an/a 1.30n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552617
PNG
(WO2022101377, Example 16)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)N[C@@H]1CCC(F)(F)C1)c1ccccc1Cl
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
WIPO WO2022101377
n/an/a 1.40n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552639
PNG
(WO2022101377, Example 38)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)NCc1ccc(cn1)C(F)(F)F)c1ccccc1Cl
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
WIPO WO2022101377
n/an/a 1.40n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552629
PNG
(WO2022101377, Example 28)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)NC1CCC1)c1ccccc1Cl
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
WIPO WO2022101377
n/an/a 1.70n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552616
PNG
(WO2022101377, Example 15)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)NCC1CC1)c1ccccc1Cl
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
WIPO WO2022101377
n/an/a 1.70n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552646
PNG
(WO2022101377, Example 45)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)NCc1ccnc(c1)C(F)(F)F)c1ccccc1Cl
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
WIPO WO2022101377
n/an/a 1.90n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552613
PNG
(WO2022101377, Example 12)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)NCc1ccc(OC(F)F)nc1)c1ccccc1Cl
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
WIPO WO2022101377
n/an/a 1.90n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552650
PNG
(WO2022101377, Example 49)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)NCc1ccc(Cl)cn1)c1ccccc1Cl
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
WIPO WO2022101377
n/an/a 1.90n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552625
PNG
(WO2022101377, Example 24)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)N1CC(C)(C)C1)c1ccccc1Cl
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
WIPO WO2022101377
n/an/a 2n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50018350
PNG
(5-(4-Methoxy-phenyl)-5-phenyl-penta-2,4-dienoic ac...)
Show SMILES COc1ccc(cc1)C(=C\C=C\C(=O)N[C@H](C)CCCc1cccnc1)\c1ccccc1
Show InChI InChI=1S/C28H30N2O2/c1-22(9-6-10-23-11-8-20-29-21-23)30-28(31)15-7-14-27(24-12-4-3-5-13-24)25-16-18-26(32-2)19-17-25/h3-5,7-8,11-22H,6,9-10H2,1-2H3,(H,30,31)/b15-7+,27-14+/t22-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 2n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]-PAF as radioligand

J Med Chem 32: 1820-35 (1989)


BindingDB Entry DOI: 10.7270/Q2NZ86MR
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011669
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCn1c2ccccc2ccc1=O)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C27H18ClN5OS/c1-17-30-31-24-16-29-26(20-9-3-4-10-22(20)28)21-15-19(35-27(21)33(17)24)8-6-14-32-23-11-5-2-7-18(23)12-13-25(32)34/h2-5,7,9-13,15H,14,16H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 2n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50004633
PNG
((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)
Show SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1)c1ccc(cc1)-n1c(C)nc2cnccc12 |t:5,7|
Show InChI InChI=1S/C34H29ClN6O3/c1-4-44-34(43)31-30(24-9-5-6-10-25(24)35)29(33(42)40-28-11-7-8-17-37-28)20(2)38-32(31)22-12-14-23(15-13-22)41-21(3)39-26-19-36-18-16-27(26)41/h5-19,29-30H,4H2,1-3H3,(H,37,40,42)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
n/an/a 2n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory effect on PAF induced platelets aggregation in rabbit

Bioorg Med Chem Lett 5: 3085-3090 (1995)


Article DOI: 10.1016/0960-894X(95)00542-7
BindingDB Entry DOI: 10.7270/Q23F4PMW
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50408421
PNG
(CHEMBL2113725)
Show SMILES CCCCN(O)C(=O)Nc1cc(cc(OC)c1OCCSc1c(F)c(F)cc(F)c1F)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C33H38F4N2O8S/c1-6-7-10-39(41)33(40)38-22-13-18(23-8-9-24(47-23)19-15-26(43-3)31(45-5)27(16-19)44-4)14-25(42-2)30(22)46-11-12-48-32-28(36)20(34)17-21(35)29(32)37/h13-17,23-24,41H,6-12H2,1-5H3,(H,38,40)/t23-,24-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Displacement of [3H]-PAF from PAF receptor of human platelet membranes

J Med Chem 41: 1970-9 (1998)


Article DOI: 10.1021/jm980046r
BindingDB Entry DOI: 10.7270/Q2PV6JH2
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50018388
PNG
(5,5-Bis-(3-methoxy-phenyl)-penta-2,4-dienoic acid ...)
Show SMILES [#6]-[#8]-c1cccc(c1)-[#6](=[#6]\[#6]=[#6]\[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]-c1cccnc1)\c1cccc(-[#8]-[#6])c1
Show InChI InChI=1S/C28H30N2O3/c1-32-25-13-5-11-23(19-25)27(24-12-6-14-26(20-24)33-2)15-7-16-28(31)30-18-4-3-9-22-10-8-17-29-21-22/h5-8,10-17,19-21H,3-4,9,18H2,1-2H3,(H,30,31)/b16-7+
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 2n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]-PAF as radioligand

J Med Chem 32: 1820-35 (1989)


BindingDB Entry DOI: 10.7270/Q2NZ86MR
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552635
PNG
(WO2022101377, Example 34)
Show SMILES CN(Cc1ccccc1)C(=O)[C@@H]1Cc2sc-3c([C@@H](NCc4nnc(C)n-34)c3ccccc3Cl)c2C1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
WIPO WO2022101377
n/an/a 2.10n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552652
PNG
(WO2022101377, Example 51)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)NC12CC(C1)C2)c1ccccc1Cl
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
WIPO WO2022101377
n/an/a 2.20n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50286206
PNG
((R)-5-tert-Butylcarbamoyl-4-(2-chloro-phenyl)-6-me...)
Show SMILES CCOC(=O)C1=C(COCCn2c(C)nc3ccccc23)N=C(C)C([C@H]1c1ccccc1Cl)C(=O)NC(C)(C)C |c:5,t:23|
Show InChI InChI=1S/C31H37ClN4O4/c1-7-40-30(38)28-24(18-39-17-16-36-20(3)34-23-14-10-11-15-25(23)36)33-19(2)26(29(37)35-31(4,5)6)27(28)21-12-8-9-13-22(21)32/h8-15,26-27H,7,16-18H2,1-6H3,(H,35,37)/t26?,27-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
n/an/a 2.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory effect on PAF induced platelets aggregation in rabbit

Bioorg Med Chem Lett 5: 3085-3090 (1995)


Article DOI: 10.1016/0960-894X(95)00542-7
BindingDB Entry DOI: 10.7270/Q23F4PMW
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50280480
PNG
(CHEMBL156461 | YM-461 | [4-(3-Phenyl-propyl)-piper...)
Show SMILES O=C([C@@H]1CSC(N1)c1cccnc1)N1CCN(CCCc2ccccc2)CC1
Show InChI InChI=1S/C22H28N4OS/c27-22(20-17-28-21(24-20)19-9-4-10-23-16-19)26-14-12-25(13-15-26)11-5-8-18-6-2-1-3-7-18/h1-4,6-7,9-10,16,20-21,24H,5,8,11-15,17H2/t20-,21?/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
n/an/a 2.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.

Bioorg Med Chem Lett 2: 597-602 (1992)


Article DOI: 10.1016/S0960-894X(01)81205-1
BindingDB Entry DOI: 10.7270/Q2CF9QK7
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552644
PNG
(WO2022101377, Example 43)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)NCc1cncc(c1)C(F)(F)F)c1ccccc1Cl
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
WIPO WO2022101377
n/an/a 2.60n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552667
PNG
(WO2022101377, Example 66)
Show SMILES Cc1nnc2CNC(c3c4C[C@@H](Cc4sc3-n12)C(=O)N1CCCC2(CC2)C1)c1ccccc1Cl
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
WIPO WO2022101377
n/an/a 2.70n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552618
PNG
(WO2022101377, Example 17)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)NCCOC(F)(F)F)c1ccccc1Cl
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
WIPO WO2022101377
n/an/a 2.80n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552634
PNG
(WO2022101377, Example 33)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)NC(C)(C)CO)c1ccccc1Cl
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
WIPO WO2022101377
n/an/a 2.80n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552638
PNG
(WO2022101377, Example 37)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)NCc1cc(ccn1)C(F)(F)F)c1ccccc1Cl
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
WIPO WO2022101377
n/an/a 2.90n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552637
PNG
(WO2022101377, Example 36)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)NCc1ncccc1C(F)(F)F)c1ccccc1Cl
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
WIPO WO2022101377
n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011673
PNG
(4-(2-Chloro-phenyl)-9-methyl-2-(3-phenoxy-prop-1-y...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCOc1ccccc1)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C24H17ClN4OS/c1-16-27-28-22-15-26-23(19-11-5-6-12-21(19)25)20-14-18(31-24(20)29(16)22)10-7-13-30-17-8-3-2-4-9-17/h2-6,8-9,11-12,14H,13,15H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 3n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50011663
PNG
(1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)Cc2ccccc12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C26H18ClN5OS/c1-16-29-30-23-15-28-25(19-9-3-4-10-21(19)27)20-14-18(34-26(20)32(16)23)8-6-12-31-22-11-5-2-7-17(22)13-24(31)33/h2-5,7,9-11,14H,12-13,15H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 3n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
PAF-antagonist activity determined in dog platelets by PAF-binding assay

J Med Chem 34: 1209-21 (1991)


BindingDB Entry DOI: 10.7270/Q23X85M1
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552620
PNG
(WO2022101377, Example 19)
Show SMILES CCCNC(=O)[C@@H]1Cc2sc-3c([C@@H](NCc4nnc(C)n-34)c3ccccc3Cl)c2C1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
WIPO WO2022101377
n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50013924
PNG
(3-(1-Butyl-4,7-dimethoxy-naphthalen-2-yl)-N-(1-met...)
Show SMILES CCCCc1c(\C=C\C(=O)N[C@@H](C)CCCc2cccnc2)cc(OC)c2ccc(OC)cc12
Show InChI InChI=1S/C29H36N2O3/c1-5-6-12-25-23(18-28(34-4)26-15-14-24(33-3)19-27(25)26)13-16-29(32)31-21(2)9-7-10-22-11-8-17-30-20-22/h8,11,13-21H,5-7,9-10,12H2,1-4H3,(H,31,32)/b16-13+/t21-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to platelet activating factor receptor citrate-treated dog blood

J Med Chem 33: 2856-64 (1990)


BindingDB Entry DOI: 10.7270/Q21V5CZJ
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50286203
PNG
(4-(2-Chloro-phenyl)-6-methyl-2-[2-(2-methyl-benzoi...)
Show SMILES CCOC(=O)C1=C(COCCn2c(C)nc3ccccc23)N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1 |c:5,t:23|
Show InChI InChI=1S/C32H32ClN5O4/c1-4-42-32(40)30-25(19-41-18-17-38-21(3)36-24-13-7-8-14-26(24)38)35-20(2)28(29(30)22-11-5-6-12-23(22)33)31(39)37-27-15-9-10-16-34-27/h5-16,28-29H,4,17-19H2,1-3H3,(H,34,37,39)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
n/an/a 3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory effect on PAF induced platelets aggregation in rabbit

Bioorg Med Chem Lett 5: 3085-3090 (1995)


Article DOI: 10.1016/0960-894X(95)00542-7
BindingDB Entry DOI: 10.7270/Q23F4PMW
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50282045
PNG
(1-{3-[5-(3-Chloro-4-methoxy-phenyl)-tetrahydro-fur...)
Show SMILES COc1ccc(cc1Cl)C1CCC(OCCCn2c(C)nc3cnccc23)O1
Show InChI InChI=1S/C21H24ClN3O3/c1-14-24-17-13-23-9-8-18(17)25(14)10-3-11-27-21-7-6-19(28-21)15-4-5-20(26-2)16(22)12-15/h4-5,8-9,12-13,19,21H,3,6-7,10-11H2,1-2H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
n/an/a 3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro

Bioorg Med Chem Lett 3: 1499-1504 (1993)


Article DOI: 10.1016/S0960-894X(00)80006-2
BindingDB Entry DOI: 10.7270/Q2CC115V
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552619
PNG
(WO2022101377, Example 18)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)N1CCC(F)(F)CC1)c1ccccc1Cl
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
WIPO WO2022101377
n/an/a 3.10n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552608
PNG
(WO2022101377, Example 7)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)NCc1ccc(nc1)C(F)(F)F)c1ccccc1Cl |r|
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
WIPO WO2022101377
n/an/a 3.60n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM552636
PNG
(WO2022101377, Example 35)
Show SMILES Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)NCc1cccc(n1)C(F)(F)F)c1ccccc1Cl
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
WIPO WO2022101377
n/an/a 3.80n/an/an/an/an/an/a


TBA

Assay Description
USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...

Citation and Details

BindingDB Entry DOI: 10.7270/Q21C212S
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 530 total )  |  Next  |  Last  >>
Jump to: