Found 13 hits Enz. Inhib. hit(s) with all data for entry = 50007680 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50066451
((3-Chloro-4-methoxy-benzyl)-(4-chloro-7-nitro-phth...)Show SMILES COc1ccc(CNc2nnc(Cl)c3ccc(cc23)[N+]([O-])=O)cc1Cl Show InChI InChI=1S/C16H12Cl2N4O3/c1-25-14-5-2-9(6-13(14)17)8-19-16-12-7-10(22(23)24)3-4-11(12)15(18)20-21-16/h2-7H,8H2,1H3,(H,19,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 5 from porcine platelets |
J Med Chem 41: 3367-72 (1998)
Article DOI: 10.1021/jm970815r
BindingDB Entry DOI: 10.7270/Q2MS3RXG |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50066450
(1-Chloro-4-(3-chloro-4-methoxy-benzylamino)-phthal...)Show InChI InChI=1S/C17H12Cl2N4O/c1-24-15-5-3-11(7-14(15)18)9-21-17-13-6-10(8-20)2-4-12(13)16(19)22-23-17/h2-7H,9H2,1H3,(H,21,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 5 from porcine platelets |
J Med Chem 41: 3367-72 (1998)
Article DOI: 10.1021/jm970815r
BindingDB Entry DOI: 10.7270/Q2MS3RXG |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50066448
((3-Chloro-4-methoxy-benzyl)-(4-chloro-7-trifluorom...)Show SMILES COc1ccc(CNc2nnc(Cl)c3ccc(cc23)C(F)(F)F)cc1Cl Show InChI InChI=1S/C17H12Cl2F3N3O/c1-26-14-5-2-9(6-13(14)18)8-23-16-12-7-10(17(20,21)22)3-4-11(12)15(19)24-25-16/h2-7H,8H2,1H3,(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 5 from porcine platelets |
J Med Chem 41: 3367-72 (1998)
Article DOI: 10.1021/jm970815r
BindingDB Entry DOI: 10.7270/Q2MS3RXG |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50066454
(CHEMBL25616 | Sodium; 1-{4-[(benzo[1,3]dioxol-5-yl...)Show SMILES [O-]C(=O)C1CCN(CC1)c1nc(NCc2ccc3OCOc3c2)c2cc(Cl)ccc2n1 Show InChI InChI=1S/C22H21ClN4O4/c23-15-2-3-17-16(10-15)20(24-11-13-1-4-18-19(9-13)31-12-30-18)26-22(25-17)27-7-5-14(6-8-27)21(28)29/h1-4,9-10,14H,5-8,11-12H2,(H,28,29)(H,24,25,26)/p-1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 5 from porcine platelets |
J Med Chem 41: 3367-72 (1998)
Article DOI: 10.1021/jm970815r
BindingDB Entry DOI: 10.7270/Q2MS3RXG |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50066447
(1-Chloro-4-(3-chloro-4-ethoxy-benzylamino)-phthala...)Show InChI InChI=1S/C18H14Cl2N4O/c1-2-25-16-6-4-12(8-15(16)19)10-22-18-14-7-11(9-21)3-5-13(14)17(20)23-24-18/h3-8H,2,10H2,1H3,(H,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 5 from porcine platelets |
J Med Chem 41: 3367-72 (1998)
Article DOI: 10.1021/jm970815r
BindingDB Entry DOI: 10.7270/Q2MS3RXG |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50066452
((3-Chloro-4-methoxy-benzyl)-(4,7-dichloro-phthalaz...)Show InChI InChI=1S/C16H12Cl3N3O/c1-23-14-5-2-9(6-13(14)18)8-20-16-12-7-10(17)3-4-11(12)15(19)21-22-16/h2-7H,8H2,1H3,(H,20,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 5 from porcine platelets |
J Med Chem 41: 3367-72 (1998)
Article DOI: 10.1021/jm970815r
BindingDB Entry DOI: 10.7270/Q2MS3RXG |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50066449
(Benzo[1,3]dioxol-5-ylmethyl-(4-chloro-7-nitro-phth...)Show SMILES [O-][N+](=O)c1ccc2c(Cl)nnc(NCc3ccc4OCOc4c3)c2c1 Show InChI InChI=1S/C16H11ClN4O4/c17-15-11-3-2-10(21(22)23)6-12(11)16(20-19-15)18-7-9-1-4-13-14(5-9)25-8-24-13/h1-6H,7-8H2,(H,18,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 5 from porcine platelets |
J Med Chem 41: 3367-72 (1998)
Article DOI: 10.1021/jm970815r
BindingDB Entry DOI: 10.7270/Q2MS3RXG |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50066457
(1-Chloro-4-[1-(3-chloro-4-methoxy-phenyl)-ethylami...)Show InChI InChI=1S/C18H14Cl2N4O/c1-10(12-4-6-16(25-2)15(19)8-12)22-18-14-7-11(9-21)3-5-13(14)17(20)23-24-18/h3-8,10H,1-2H3,(H,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 98 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 5 from porcine platelets |
J Med Chem 41: 3367-72 (1998)
Article DOI: 10.1021/jm970815r
BindingDB Entry DOI: 10.7270/Q2MS3RXG |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50066446
(4-[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-1-chloro-p...)Show InChI InChI=1S/C17H11ClN4O2/c18-16-12-3-1-10(7-19)5-13(12)17(22-21-16)20-8-11-2-4-14-15(6-11)24-9-23-14/h1-6H,8-9H2,(H,20,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 5 from porcine platelets |
J Med Chem 41: 3367-72 (1998)
Article DOI: 10.1021/jm970815r
BindingDB Entry DOI: 10.7270/Q2MS3RXG |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50066445
(4-Chloro-1-(3-chloro-4-methoxy-benzylamino)-phthal...)Show InChI InChI=1S/C17H12Cl2N4O/c1-24-15-5-3-11(7-14(15)18)9-21-17-12-4-2-10(8-20)6-13(12)16(19)22-23-17/h2-7H,9H2,1H3,(H,21,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 5 from porcine platelets |
J Med Chem 41: 3367-72 (1998)
Article DOI: 10.1021/jm970815r
BindingDB Entry DOI: 10.7270/Q2MS3RXG |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50066456
(1-Chloro-4-(4-methoxy-benzylamino)-phthalazine-6-c...)Show InChI InChI=1S/C17H13ClN4O/c1-23-13-5-2-11(3-6-13)10-20-17-15-8-12(9-19)4-7-14(15)16(18)21-22-17/h2-8H,10H2,1H3,(H,20,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 5 from porcine platelets |
J Med Chem 41: 3367-72 (1998)
Article DOI: 10.1021/jm970815r
BindingDB Entry DOI: 10.7270/Q2MS3RXG |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50066455
((3-Chloro-4-methoxy-benzyl)-(4,6-dichloro-phthalaz...)Show InChI InChI=1S/C16H12Cl3N3O/c1-23-14-5-2-9(6-13(14)18)8-20-16-11-4-3-10(17)7-12(11)15(19)21-22-16/h2-7H,8H2,1H3,(H,20,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 810 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 5 from porcine platelets |
J Med Chem 41: 3367-72 (1998)
Article DOI: 10.1021/jm970815r
BindingDB Entry DOI: 10.7270/Q2MS3RXG |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50066453
(Benzo[1,3]dioxol-5-ylmethyl-(4-chloro-6-nitro-phth...)Show SMILES [O-][N+](=O)c1ccc2c(NCc3ccc4OCOc4c3)nnc(Cl)c2c1 Show InChI InChI=1S/C16H11ClN4O4/c17-15-12-6-10(21(22)23)2-3-11(12)16(20-19-15)18-7-9-1-4-13-14(5-9)25-8-24-13/h1-6H,7-8H2,(H,18,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of Phosphodiesterase 5 from porcine platelets |
J Med Chem 41: 3367-72 (1998)
Article DOI: 10.1021/jm970815r
BindingDB Entry DOI: 10.7270/Q2MS3RXG |
More data for this
Ligand-Target Pair | |
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