Found 98 hits of ki for UniProtKB: P35353 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50087556
((4-Fluoro-butyl)-propyl-[2,5,6-trimethyl-7-(2,4,6-...)Show SMILES CCCN(CCCCF)c1nc(C)nc2n(c(C)c(C)c12)-c1c(C)cc(C)cc1C |(7.65,-.09,;7.16,-1.55,;8.19,-2.71,;7.72,-4.17,;6.2,-4.5,;5.18,-3.35,;3.67,-3.67,;2.64,-2.53,;1.13,-2.84,;8.75,-5.32,;8.28,-6.79,;9.31,-7.93,;8.85,-9.41,;10.81,-7.61,;11.29,-6.15,;12.7,-5.53,;12.54,-3.98,;13.69,-2.95,;11.02,-3.67,;10.4,-2.25,;10.26,-5,;14.04,-6.29,;14.04,-7.84,;12.7,-8.61,;15.37,-8.61,;16.7,-7.84,;18.05,-8.61,;16.7,-6.29,;15.37,-5.52,;15.36,-3.97,)| Show InChI InChI=1S/C25H35FN4/c1-8-12-29(13-10-9-11-26)24-22-19(5)20(6)30(25(22)28-21(7)27-24)23-17(3)14-16(2)15-18(23)4/h14-15H,8-13H2,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.910 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NIDDK
Curated by ChEMBL
| Assay Description
Compound was tested in vitro for its ability to displace [125 I]Tyr-sauvagine from corticotropin-releasing hormone type 1 receptor in rat cerebellum |
Bioorg Med Chem Lett 10: 707-10 (2000)
BindingDB Entry DOI: 10.7270/Q2SB44ZX |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM35723
(CHEMBL344159 | N-[4-(7-Chloro-5-hydroxy-2,3,4,5-te...)Show SMILES Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(O)c3cc(Cl)ccc23)c(C)c1 Show InChI InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-Synthelabo
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 301: 322-32 (2002)
Article DOI: 10.1124/jpet.301.1.322
BindingDB Entry DOI: 10.7270/Q2MP51VM |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50074501
(Butyl-ethyl-[2,5,6-trimethyl-7-(2,4,6-trimethyl-ph...)Show SMILES CCCCN(CC)c1nc(C)nc2n(c(C)c(C)c12)-c1c(C)cc(C)cc1C |(4.9,1.82,;3.57,2.56,;2.24,1.79,;.91,2.55,;-.44,1.78,;-1.76,2.55,;-3.1,1.78,;-.42,.25,;-1.75,-.52,;-1.75,-2.06,;-3.08,-2.83,;-.42,-2.83,;.91,-2.06,;2.38,-2.54,;3.31,-1.29,;4.85,-1.29,;2.38,-.03,;2.86,1.43,;.91,-.52,;2.86,-4.02,;4.37,-4.33,;5.39,-3.17,;4.85,-5.78,;3.82,-6.93,;4.31,-8.4,;2.32,-6.61,;1.84,-5.14,;.33,-4.82,)| Show InChI InChI=1S/C24H34N4/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5/h13-14H,9-12H2,1-8H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institutes of Health
Curated by ChEMBL
| Assay Description
Affinity for the Corticotropin releasing factor receptor 1 (CRHR1) was determined in rat brain |
J Med Chem 46: 3559-62 (2003)
Article DOI: 10.1021/jm034077k
BindingDB Entry DOI: 10.7270/Q2NS0VN9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50074439
(1-(2-Bromo-4,6-dimethoxy-phenyl)-4,6-dimethyl-1H-p...)Show SMILES COc1cc(Br)c(c(OC)c1)-n1ccc2c(C)cc(C)nc12 |(12.47,-15.06,;10.97,-14.75,;10.48,-13.3,;11.5,-12.14,;11.01,-10.69,;12.02,-9.53,;9.5,-10.37,;8.48,-11.53,;6.98,-11.21,;5.96,-12.35,;8.97,-12.98,;9.03,-8.92,;9.92,-7.66,;9.01,-6.42,;7.54,-6.91,;6.21,-6.14,;6.21,-4.6,;4.88,-6.91,;4.88,-8.45,;3.55,-9.22,;6.21,-9.22,;7.56,-8.45,)| Show InChI InChI=1S/C17H17BrN2O2/c1-10-7-11(2)19-17-13(10)5-6-20(17)16-14(18)8-12(21-3)9-15(16)22-4/h5-9H,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1 |
J Med Chem 42: 819-32 (1999)
Article DOI: 10.1021/jm980223o
BindingDB Entry DOI: 10.7270/Q22V2GT5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM35723
(CHEMBL344159 | N-[4-(7-Chloro-5-hydroxy-2,3,4,5-te...)Show SMILES Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(O)c3cc(Cl)ccc23)c(C)c1 Show InChI InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-Synthelabo
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 301: 322-32 (2002)
Article DOI: 10.1124/jpet.301.1.322
BindingDB Entry DOI: 10.7270/Q2MP51VM |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50058163
(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)Show SMILES CCCCN(CC)c1nc(C)nc2n(cc(C)c12)-c1c(C)cc(C)cc1C |(-10.62,2.69,;-9.29,3.46,;-7.95,2.7,;-6.62,3.48,;-5.28,2.71,;-3.95,3.49,;-3.96,5.03,;-5.27,1.17,;-6.6,.4,;-6.6,-1.14,;-7.94,-1.91,;-5.27,-1.91,;-3.92,-1.14,;-2.44,-1.61,;-1.54,-.35,;-2.46,.9,;-1.99,2.37,;-3.93,.41,;-1.96,-3.07,;-2.99,-4.22,;-4.49,-3.91,;-2.5,-5.68,;-.99,-5.99,;-.51,-7.46,;.03,-4.83,;-.46,-3.38,;.56,-2.22,)| Show InChI InChI=1S/C23H32N4/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5/h12-14H,8-11H2,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 289: 926-35 (1999)
BindingDB Entry DOI: 10.7270/Q2GM85VG |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50131716
(CHEMBL430892 | [3-(4-Bromo-2-chloro-phenyl)-2,5-di...)Show SMILES COCCN(CCOC)c1nc(C)nc2c(c(C)nn12)-c1ccc(Br)cc1Cl |(2.5,2.36,;1.17,3.13,;-.17,2.36,;-1.5,3.12,;-2.85,2.35,;-4.18,3.11,;-5.51,2.34,;-6.84,3.11,;-8.17,2.34,;-2.83,.81,;-4.16,.04,;-4.16,-1.51,;-5.51,-2.28,;-2.83,-2.28,;-1.49,-1.5,;-.03,-1.98,;.88,-.73,;2.42,-.73,;-.03,.52,;-1.49,.04,;.44,-3.44,;-.59,-4.58,;-.12,-6.04,;1.39,-6.36,;1.87,-7.83,;2.43,-5.21,;1.94,-3.75,;2.96,-2.61,)| Show InChI InChI=1S/C19H23BrClN5O2/c1-12-17(15-6-5-14(20)11-16(15)21)18-22-13(2)23-19(26(18)24-12)25(7-9-27-3)8-10-28-4/h5-6,11H,7-10H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institutes of Health
Curated by ChEMBL
| Assay Description
Affinity for the Corticotropin releasing factor receptor 1 (CRHR1) was determined in rat brain |
J Med Chem 46: 3559-62 (2003)
Article DOI: 10.1021/jm034077k
BindingDB Entry DOI: 10.7270/Q2NS0VN9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50087559
(CHEMBL164206 | Cyclopropylmethyl-propyl-[2,5,6-tri...)Show SMILES CCCN(CC1CC1)c1nc(C)nc2n(c(C)c(C)c12)-c1c(C)cc(C)cc1C |(2.88,-3.62,;4.39,-3.31,;5.41,-4.46,;6.91,-4.14,;7.4,-2.67,;6.37,-1.52,;6.03,-.01,;4.9,-1.05,;7.96,-5.28,;7.47,-6.74,;8.52,-7.89,;8.03,-9.36,;10.01,-7.57,;10.48,-6.1,;11.88,-5.48,;11.72,-3.95,;12.86,-2.92,;10.22,-3.62,;9.6,-2.22,;9.46,-4.95,;13.21,-6.25,;13.21,-7.79,;11.88,-8.56,;14.54,-8.56,;15.89,-7.79,;17.23,-8.56,;15.89,-6.24,;14.54,-5.47,;14.54,-3.93,)| Show InChI InChI=1S/C25H34N4/c1-8-11-28(14-21-9-10-21)24-22-18(5)19(6)29(25(22)27-20(7)26-24)23-16(3)12-15(2)13-17(23)4/h12-13,21H,8-11,14H2,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 2.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NIDDK
Curated by ChEMBL
| Assay Description
Compound was tested in vitro for its ability to displace [125 I]Tyr-sauvagine from corticotropin-releasing hormone type 1 receptor in rat cerebellum |
Bioorg Med Chem Lett 10: 707-10 (2000)
BindingDB Entry DOI: 10.7270/Q2SB44ZX |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50074501
(Butyl-ethyl-[2,5,6-trimethyl-7-(2,4,6-trimethyl-ph...)Show SMILES CCCCN(CC)c1nc(C)nc2n(c(C)c(C)c12)-c1c(C)cc(C)cc1C |(4.9,1.82,;3.57,2.56,;2.24,1.79,;.91,2.55,;-.44,1.78,;-1.76,2.55,;-3.1,1.78,;-.42,.25,;-1.75,-.52,;-1.75,-2.06,;-3.08,-2.83,;-.42,-2.83,;.91,-2.06,;2.38,-2.54,;3.31,-1.29,;4.85,-1.29,;2.38,-.03,;2.86,1.43,;.91,-.52,;2.86,-4.02,;4.37,-4.33,;5.39,-3.17,;4.85,-5.78,;3.82,-6.93,;4.31,-8.4,;2.32,-6.61,;1.84,-5.14,;.33,-4.82,)| Show InChI InChI=1S/C24H34N4/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5/h13-14H,9-12H2,1-8H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NIDDK
Curated by ChEMBL
| Assay Description
Compound was tested in vitro for its ability to displace [125 I]Tyr-sauvagine from corticotropin-releasing hormone type 1 receptor in rat cerebellum |
Bioorg Med Chem Lett 10: 707-10 (2000)
BindingDB Entry DOI: 10.7270/Q2SB44ZX |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50096721
(5-Chloro-N-cyclopropylmethyl-N'-(2,6-dichloro-4-tr...)Show SMILES CCCC[Sn](CCCC)(CCCC)c1cc(Cl)c(Nc2nc(C)nc(N(CCC)CC3CC3)c2Cl)c(Cl)c1 Show InChI InChI=1S/C18H20Cl3N4.3C4H9.Sn/c1-3-9-25(10-12-7-8-12)18-15(21)17(22-11(2)23-18)24-16-13(19)5-4-6-14(16)20;3*1-3-4-2;/h5-6,12H,3,7-10H2,1-2H3,(H,22,23,24);3*1,3-4H2,2H3; | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NIDDK
Curated by ChEMBL
| Assay Description
Binding affinity towards Corticotropin releasing hormone receptor type 1 of rat cerebellum using [125I]-Tyr-sauvagine as radioligand. |
Bioorg Med Chem Lett 11: 331-3 (2001)
BindingDB Entry DOI: 10.7270/Q21G0KHH |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50087560
(CHEMBL348967 | Ethyl-(4-fluoro-butyl)-[2,5,6-trime...)Show SMILES CCN(CCCCF)c1nc(C)nc2n(c(C)c(C)c12)-c1c(C)cc(C)cc1C |(6.4,-1.55,;7.43,-2.71,;6.95,-4.16,;5.44,-4.49,;4.42,-3.34,;2.9,-3.66,;1.87,-2.52,;.37,-2.83,;7.98,-5.3,;7.5,-6.77,;8.54,-7.91,;8.07,-9.38,;10.04,-7.59,;10.5,-6.13,;11.92,-5.51,;11.76,-3.97,;12.9,-2.95,;10.25,-3.66,;9.62,-2.25,;9.48,-4.99,;13.25,-6.27,;13.25,-7.82,;11.9,-8.59,;14.58,-8.59,;15.92,-7.82,;17.24,-8.59,;15.92,-6.27,;14.58,-5.5,;14.56,-3.97,)| Show InChI InChI=1S/C24H33FN4/c1-8-28(12-10-9-11-25)23-21-18(5)19(6)29(24(21)27-20(7)26-23)22-16(3)13-15(2)14-17(22)4/h13-14H,8-12H2,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 3.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NIDDK
Curated by ChEMBL
| Assay Description
Compound was tested in vitro for its ability to displace [125 I]Tyr-sauvagine from corticotropin-releasing hormone type 1 receptor in rat cerebellum |
Bioorg Med Chem Lett 10: 707-10 (2000)
BindingDB Entry DOI: 10.7270/Q2SB44ZX |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50116105
(3-(6-(dimethylamino)-4-methylpyridin-3-yl)-2,5-dim...)Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(-1.91,-13.39,;-3.24,-14.16,;-4.58,-13.4,;-5.91,-14.18,;-7.24,-13.41,;-8.57,-14.19,;-9.91,-13.42,;-5.9,-15.72,;-7.22,-16.49,;-7.23,-18.03,;-8.56,-18.8,;-5.9,-18.8,;-4.55,-18.03,;-3.07,-18.5,;-2.16,-17.24,;-.62,-17.23,;-3.09,-15.99,;-4.56,-16.48,;-2.58,-19.96,;-3.61,-21.11,;-3.13,-22.57,;-1.62,-22.88,;-.59,-21.72,;-1.08,-20.27,;-.06,-19.11,;-1.13,-24.34,;.38,-24.65,;-2.15,-25.5,)| Show InChI InChI=1S/C22H32N6/c1-8-10-27(11-9-2)20-13-16(4)24-22-21(17(5)25-28(20)22)18-14-23-19(26(6)7)12-15(18)3/h12-14H,8-11H2,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 3.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]-sauvagine from rat CRF-1 receptor expressed in rat cortical membrane after 2 hrs by scintillation counting |
J Med Chem 54: 4187-206 (2011)
Article DOI: 10.1021/jm200365y
BindingDB Entry DOI: 10.7270/Q2XS5VR1 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50074411
((2-Bromo-4,6-dimethoxy-phenyl)-(4,6-dimethyl-pyrim...)Show InChI InChI=1S/C16H20BrN3O2/c1-6-20(16-18-10(2)7-11(3)19-16)15-13(17)8-12(21-4)9-14(15)22-5/h7-9H,6H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1 |
J Med Chem 42: 819-32 (1999)
Article DOI: 10.1021/jm980223o
BindingDB Entry DOI: 10.7270/Q22V2GT5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50348782
(CHEMBL1807053)Show SMILES CCC(CC)Nc1nc(C)c(nc1OC)-c1ccc(OC(F)(F)F)cc1OC Show InChI InChI=1S/C19H24F3N3O3/c1-6-12(7-2)24-17-18(27-5)25-16(11(3)23-17)14-9-8-13(10-15(14)26-4)28-19(20,21)22/h8-10,12H,6-7H2,1-5H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| 9.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]-sauvagine from rat CRF-1 receptor expressed in rat cortical membrane after 2 hrs by scintillation counting |
J Med Chem 54: 4187-206 (2011)
Article DOI: 10.1021/jm200365y
BindingDB Entry DOI: 10.7270/Q2XS5VR1 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50087561
(Butyl-(4-fluoro-butyl)-[2,5,6-trimethyl-7-(2,4,6-t...)Show SMILES CCCCN(CCCCF)c1nc(C)nc2n(c(C)c(C)c12)-c1c(C)cc(C)cc1C |(6.62,.32,;7.65,-.83,;7.16,-2.29,;8.19,-3.44,;7.72,-4.91,;6.2,-5.22,;5.18,-4.08,;3.67,-4.4,;2.64,-3.26,;1.13,-3.58,;8.75,-6.06,;8.28,-7.51,;9.31,-8.66,;8.85,-10.13,;10.81,-8.35,;11.29,-6.88,;12.7,-6.25,;12.54,-4.72,;13.69,-3.68,;11.02,-4.4,;10.4,-2.99,;10.26,-5.74,;14.04,-7.02,;14.04,-8.57,;12.7,-9.34,;15.37,-9.34,;16.7,-8.57,;18.05,-9.34,;16.7,-7.02,;15.37,-6.25,;15.36,-4.71,)| Show InChI InChI=1S/C26H37FN4/c1-8-9-13-30(14-11-10-12-27)25-23-20(5)21(6)31(26(23)29-22(7)28-25)24-18(3)15-17(2)16-19(24)4/h15-16H,8-14H2,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NIDDK
Curated by ChEMBL
| Assay Description
Compound was tested in vitro for its ability to displace [125 I]Tyr-sauvagine from corticotropin-releasing hormone type 1 receptor in rat cerebellum |
Bioorg Med Chem Lett 10: 707-10 (2000)
BindingDB Entry DOI: 10.7270/Q2SB44ZX |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50096722
(5-Chloro-N-cyclopropylmethyl-N'-(2,6-dichloro-4-io...)Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(I)cc2Cl)c1Cl Show InChI InChI=1S/C18H20Cl3IN4/c1-3-6-26(9-11-4-5-11)18-15(21)17(23-10(2)24-18)25-16-13(19)7-12(22)8-14(16)20/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NIDDK
Curated by ChEMBL
| Assay Description
Binding affinity towards Corticotropin releasing hormone receptor type 1 of rat cerebellum using [125I]-Tyr-sauvagine as radioligand. |
Bioorg Med Chem Lett 11: 331-3 (2001)
BindingDB Entry DOI: 10.7270/Q21G0KHH |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50074456
(CHEMBL10504 | SC241 | [3-(2-Bromo-4-isopropyl-phen...)Show SMILES COCCN(CCOC)c1nc(C)nc2n(nnc12)-c1ccc(cc1Br)C(C)C Show InChI InChI=1S/C20H27BrN6O2/c1-13(2)15-6-7-17(16(21)12-15)27-20-18(24-25-27)19(22-14(3)23-20)26(8-10-28-4)9-11-29-5/h6-7,12-13H,8-11H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 14.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 289: 926-35 (1999)
BindingDB Entry DOI: 10.7270/Q2GM85VG |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM85397
(CRA1000)Show SMILES CCN(c1nc(C)cc(n1)N1CCC=C(C1)c1cccc(F)c1)c1ccc(CC(C)C)cc1SC |c:14| Show InChI InChI=1S/C29H35FN4S/c1-6-34(26-13-12-22(15-20(2)3)17-27(26)35-5)29-31-21(4)16-28(32-29)33-14-8-10-24(19-33)23-9-7-11-25(30)18-23/h7,9-13,16-18,20H,6,8,14-15,19H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| PubMed
| 15.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 289: 926-35 (1999)
BindingDB Entry DOI: 10.7270/Q2GM85VG |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50177574
(3-(4-(2-methoxybenzyloxy)phenylsulfonyl)-N-mesityl...)Show SMILES COc1ccccc1COc1ccc(cc1)S(=O)(=O)c1ccc(C)nc1Nc1c(C)cc(C)cc1C Show InChI InChI=1S/C29H30N2O4S/c1-19-16-20(2)28(21(3)17-19)31-29-27(15-10-22(4)30-29)36(32,33)25-13-11-24(12-14-25)35-18-23-8-6-7-9-26(23)34-5/h6-17H,18H2,1-5H3,(H,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Tyr-o-CRF from CRF1 receptor in rat frontal cortex homogenates |
Bioorg Med Chem Lett 16: 934-7 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.097
BindingDB Entry DOI: 10.7270/Q2J102Q5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM85398
(CRA1001)Show SMILES CCN(c1nc(C)cc(n1)N1CCC=C(C1)c1cccc(F)c1)c1ccc(CC(C)C)cc1Br |c:14| Show InChI InChI=1S/C28H32BrFN4/c1-5-34(26-12-11-21(14-19(2)3)16-25(26)29)28-31-20(4)15-27(32-28)33-13-7-9-23(18-33)22-8-6-10-24(30)17-22/h6,8-12,15-17,19H,5,7,13-14,18H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| PubMed
| 18.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 289: 926-35 (1999)
BindingDB Entry DOI: 10.7270/Q2GM85VG |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM85397
(CRA1000)Show SMILES CCN(c1nc(C)cc(n1)N1CCC=C(C1)c1cccc(F)c1)c1ccc(CC(C)C)cc1SC |c:14| Show InChI InChI=1S/C29H35FN4S/c1-6-34(26-13-12-22(15-20(2)3)17-27(26)35-5)29-31-21(4)16-28(32-29)33-14-8-10-24(19-33)23-9-7-11-25(30)18-23/h7,9-13,16-18,20H,6,8,14-15,19H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| PubMed
| 20.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 289: 926-35 (1999)
BindingDB Entry DOI: 10.7270/Q2GM85VG |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50074456
(CHEMBL10504 | SC241 | [3-(2-Bromo-4-isopropyl-phen...)Show SMILES COCCN(CCOC)c1nc(C)nc2n(nnc12)-c1ccc(cc1Br)C(C)C Show InChI InChI=1S/C20H27BrN6O2/c1-13(2)15-6-7-17(16(21)12-15)27-20-18(24-25-27)19(22-14(3)23-20)26(8-10-28-4)9-11-29-5/h6-7,12-13H,8-11H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 20.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 289: 926-35 (1999)
BindingDB Entry DOI: 10.7270/Q2GM85VG |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50096723
(CHEMBL113333 | N-(4-Bromo-2,6-dichloro-phenyl)-5-c...)Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Br)cc2Cl)c1Cl Show InChI InChI=1S/C18H20BrCl3N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NIDDK
Curated by ChEMBL
| Assay Description
Binding affinity towards Corticotropin releasing hormone receptor type 1 of rat cerebellum using [125I]-Tyr-sauvagine as radioligand. |
Bioorg Med Chem Lett 11: 331-3 (2001)
BindingDB Entry DOI: 10.7270/Q21G0KHH |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50074372
((2-Bromo-4-isopropyl-phenyl)-ethyl-(4-methyl-6-mor...)Show SMILES CCN(c1nc(C)cc(n1)N1CCOCC1)c1ccc(cc1Br)C(C)C Show InChI InChI=1S/C20H27BrN4O/c1-5-25(18-7-6-16(14(2)3)13-17(18)21)20-22-15(4)12-19(23-20)24-8-10-26-11-9-24/h6-7,12-14H,5,8-11H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1 |
J Med Chem 42: 819-32 (1999)
Article DOI: 10.1021/jm980223o
BindingDB Entry DOI: 10.7270/Q22V2GT5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM85398
(CRA1001)Show SMILES CCN(c1nc(C)cc(n1)N1CCC=C(C1)c1cccc(F)c1)c1ccc(CC(C)C)cc1Br |c:14| Show InChI InChI=1S/C28H32BrFN4/c1-5-34(26-12-11-21(14-19(2)3)16-25(26)29)28-31-20(4)15-27(32-28)33-13-7-9-23(18-33)22-8-6-10-24(30)17-22/h6,8-12,15-17,19H,5,7,13-14,18H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| PubMed
| 22.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 289: 926-35 (1999)
BindingDB Entry DOI: 10.7270/Q2GM85VG |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50074435
(1-(2-Bromo-4-isopropyl-phenyl)-6-methyl-4-morpholi...)Show SMILES CC(C)c1ccc(c(Br)c1)-n1ccc2c(cc(C)nc12)N1CCOCC1 Show InChI InChI=1S/C21H24BrN3O/c1-14(2)16-4-5-19(18(22)13-16)25-7-6-17-20(12-15(3)23-21(17)25)24-8-10-26-11-9-24/h4-7,12-14H,8-11H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1 |
J Med Chem 42: 819-32 (1999)
Article DOI: 10.1021/jm980223o
BindingDB Entry DOI: 10.7270/Q22V2GT5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50074420
(1-(2-Bromo-4,6-dimethoxy-phenyl)-4,6-dimethyl-1H-p...)Show SMILES COc1cc(Br)c(c(OC)c1)-n1cc(C#N)c2c(C)cc(C)nc12 |(12.47,-15.06,;10.97,-14.75,;10.48,-13.3,;11.5,-12.14,;11.01,-10.69,;12.02,-9.53,;9.5,-10.37,;8.48,-11.53,;6.98,-11.21,;5.96,-12.35,;8.97,-12.98,;9.03,-8.92,;9.92,-7.66,;9.01,-6.42,;9.48,-4.95,;9.95,-3.48,;7.54,-6.91,;6.21,-6.14,;6.21,-4.6,;4.88,-6.91,;4.88,-8.45,;3.55,-9.22,;6.21,-9.22,;7.56,-8.45,)| Show InChI InChI=1S/C18H16BrN3O2/c1-10-5-11(2)21-18-16(10)12(8-20)9-22(18)17-14(19)6-13(23-3)7-15(17)24-4/h5-7,9H,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1 |
J Med Chem 42: 819-32 (1999)
Article DOI: 10.1021/jm980223o
BindingDB Entry DOI: 10.7270/Q22V2GT5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50087557
(CHEMBL164042 | Cyclopropylmethyl-(3-fluoro-propyl)...)Show SMILES Cc1c(C)c2c(nc(C)nc2n1-c1c(C)cc(C)cc1C)N(CCCF)CC1CC1 |(12.37,-3.71,;11.23,-4.74,;9.73,-4.41,;9.1,-3.01,;8.96,-5.74,;7.47,-6.07,;6.98,-7.53,;8.02,-8.67,;7.55,-10.14,;9.52,-8.35,;9.98,-6.88,;11.4,-6.27,;12.72,-7.04,;14.05,-6.25,;14.04,-4.72,;15.39,-7.02,;15.39,-8.58,;16.72,-9.35,;14.05,-9.35,;12.72,-8.58,;11.38,-9.35,;6.43,-4.93,;4.93,-5.24,;3.9,-4.1,;2.38,-4.41,;1.36,-3.27,;6.91,-3.46,;5.88,-2.32,;5.55,-.8,;4.41,-1.84,)| Show InChI InChI=1S/C25H33FN4/c1-15-12-16(2)23(17(3)13-15)30-19(5)18(4)22-24(27-20(6)28-25(22)30)29(11-7-10-26)14-21-8-9-21/h12-13,21H,7-11,14H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NIDDK
Curated by ChEMBL
| Assay Description
Compound was tested in vitro for its ability to displace [125 I]Tyr-sauvagine from corticotropin-releasing hormone type 1 receptor in rat cerebellum |
Bioorg Med Chem Lett 10: 707-10 (2000)
BindingDB Entry DOI: 10.7270/Q2SB44ZX |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50054245
(5-Chloro-N-cyclopropylmethyl-2-methyl-N-propyl-N''...)Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1Cl Show InChI InChI=1S/C18H20Cl4N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| PubMed
| 31 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NIDDK
Curated by ChEMBL
| Assay Description
Binding affinity towards Corticotropin releasing hormone receptor type 1 of rat cerebellum using [125I]-Tyr-sauvagine as radioligand. |
Bioorg Med Chem Lett 11: 331-3 (2001)
BindingDB Entry DOI: 10.7270/Q21G0KHH |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50177568
(3-(4-(benzyloxy)phenylsulfonyl)-N-mesityl-6-methyl...)Show SMILES Cc1cc(C)c(Nc2nc(C)ccc2S(=O)(=O)c2ccc(OCc3ccccc3)cc2)c(C)c1 Show InChI InChI=1S/C28H28N2O3S/c1-19-16-20(2)27(21(3)17-19)30-28-26(15-10-22(4)29-28)34(31,32)25-13-11-24(12-14-25)33-18-23-8-6-5-7-9-23/h5-17H,18H2,1-4H3,(H,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Tyr-o-CRF from CRF1 receptor in rat frontal cortex homogenates |
Bioorg Med Chem Lett 16: 934-7 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.097
BindingDB Entry DOI: 10.7270/Q2J102Q5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50177576
(3-(4-(3,5-dimethoxybenzyloxy)phenylsulfonyl)-N-mes...)Show SMILES COc1cc(COc2ccc(cc2)S(=O)(=O)c2ccc(C)nc2Nc2c(C)cc(C)cc2C)cc(OC)c1 Show InChI InChI=1S/C30H32N2O5S/c1-19-13-20(2)29(21(3)14-19)32-30-28(12-7-22(4)31-30)38(33,34)27-10-8-24(9-11-27)37-18-23-15-25(35-5)17-26(16-23)36-6/h7-17H,18H2,1-6H3,(H,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Tyr-o-CRF from CRF1 receptor in rat frontal cortex homogenates |
Bioorg Med Chem Lett 16: 934-7 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.097
BindingDB Entry DOI: 10.7270/Q2J102Q5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50074425
(1-(2-Bromo-4-isopropyl-phenyl)-6-methyl-4-phenyl-1...)Show SMILES CC(C)c1ccc(c(Br)c1)-n1cc(C#N)c2c(cc(C)nc12)-c1ccccc1 Show InChI InChI=1S/C24H20BrN3/c1-15(2)18-9-10-22(21(25)12-18)28-14-19(13-26)23-20(11-16(3)27-24(23)28)17-7-5-4-6-8-17/h4-12,14-15H,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1 |
J Med Chem 42: 819-32 (1999)
Article DOI: 10.1021/jm980223o
BindingDB Entry DOI: 10.7270/Q22V2GT5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50074429
(1-(2-Bromo-4-isopropyl-phenyl)-6-methyl-4-phenyl-1...)Show SMILES CC(C)c1ccc(c(Br)c1)-n1ccc2c(cc(C)nc12)-c1ccccc1 Show InChI InChI=1S/C23H21BrN2/c1-15(2)18-9-10-22(21(24)14-18)26-12-11-19-20(13-16(3)25-23(19)26)17-7-5-4-6-8-17/h4-15H,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1 |
J Med Chem 42: 819-32 (1999)
Article DOI: 10.1021/jm980223o
BindingDB Entry DOI: 10.7270/Q22V2GT5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50074351
((4,6-Dimethyl-pyrimidin-2-yl)-ethyl-(2-iodo-4-isop...)Show InChI InChI=1S/C17H22IN3/c1-6-21(17-19-12(4)9-13(5)20-17)16-8-7-14(11(2)3)10-15(16)18/h7-11H,6H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1 |
J Med Chem 42: 819-32 (1999)
Article DOI: 10.1021/jm980223o
BindingDB Entry DOI: 10.7270/Q22V2GT5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50074351
((4,6-Dimethyl-pyrimidin-2-yl)-ethyl-(2-iodo-4-isop...)Show InChI InChI=1S/C17H22IN3/c1-6-21(17-19-12(4)9-13(5)20-17)16-8-7-14(11(2)3)10-15(16)18/h7-11H,6H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description
Binding affinity of the compound was measured on rat Corticotropin releasing factor receptor 1 |
J Med Chem 42: 805-18 (1999)
Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50074353
((2-Bromo-4,6-dimethoxy-phenyl)-ethyl-(4-methyl-6-m...)Show SMILES CCN(c1nc(C)nc(n1)N1CCOCC1)c1c(Br)cc(OC)cc1OC Show InChI InChI=1S/C18H24BrN5O3/c1-5-24(16-14(19)10-13(25-3)11-15(16)26-4)18-21-12(2)20-17(22-18)23-6-8-27-9-7-23/h10-11H,5-9H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 43 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1 |
J Med Chem 42: 819-32 (1999)
Article DOI: 10.1021/jm980223o
BindingDB Entry DOI: 10.7270/Q22V2GT5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50074350
((2-Bromo-4-isopropyl-phenyl)-(4,6-dimethyl-pyrimid...)Show InChI InChI=1S/C17H22BrN3/c1-6-21(17-19-12(4)9-13(5)20-17)16-8-7-14(11(2)3)10-15(16)18/h7-11H,6H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 46 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1 |
J Med Chem 42: 819-32 (1999)
Article DOI: 10.1021/jm980223o
BindingDB Entry DOI: 10.7270/Q22V2GT5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50074350
((2-Bromo-4-isopropyl-phenyl)-(4,6-dimethyl-pyrimid...)Show InChI InChI=1S/C17H22BrN3/c1-6-21(17-19-12(4)9-13(5)20-17)16-8-7-14(11(2)3)10-15(16)18/h7-11H,6H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 46 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description
Binding affinity of the compound was measured on rat Corticotropin releasing factor receptor 1 |
J Med Chem 42: 805-18 (1999)
Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50074437
(1-(2-Bromo-4-isopropyl-phenyl)-4,6-dimethyl-1H-pyr...)Show InChI InChI=1S/C18H19BrN2/c1-11(2)14-5-6-17(16(19)10-14)21-8-7-15-12(3)9-13(4)20-18(15)21/h5-11H,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 47 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1 |
J Med Chem 42: 819-32 (1999)
Article DOI: 10.1021/jm980223o
BindingDB Entry DOI: 10.7270/Q22V2GT5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50074432
((4,6-Dimethyl-pyrimidin-2-yl)-(2-iodo-4-isopropyl-...)Show InChI InChI=1S/C16H20IN3/c1-10(2)13-6-7-15(14(17)9-13)20(5)16-18-11(3)8-12(4)19-16/h6-10H,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 48 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1 |
J Med Chem 42: 819-32 (1999)
Article DOI: 10.1021/jm980223o
BindingDB Entry DOI: 10.7270/Q22V2GT5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50177581
(CHEMBL437893 | methyl 3-((4-(2-(mesitylamino)-6-me...)Show SMILES COC(=O)c1cccc(COc2ccc(cc2)S(=O)(=O)c2ccc(C)nc2Nc2c(C)cc(C)cc2C)c1 Show InChI InChI=1S/C30H30N2O5S/c1-19-15-20(2)28(21(3)16-19)32-29-27(14-9-22(4)31-29)38(34,35)26-12-10-25(11-13-26)37-18-23-7-6-8-24(17-23)30(33)36-5/h6-17H,18H2,1-5H3,(H,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 49 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Tyr-o-CRF from CRF1 receptor in rat frontal cortex homogenates |
Bioorg Med Chem Lett 16: 934-7 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.097
BindingDB Entry DOI: 10.7270/Q2J102Q5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50177584
(3-(4-ethylphenylsulfonyl)-N-mesityl-6-methylpyridi...)Show SMILES CCc1ccc(cc1)S(=O)(=O)c1ccc(C)nc1Nc1c(C)cc(C)cc1C Show InChI InChI=1S/C23H26N2O2S/c1-6-19-8-10-20(11-9-19)28(26,27)21-12-7-18(5)24-23(21)25-22-16(3)13-15(2)14-17(22)4/h7-14H,6H2,1-5H3,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 52 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Tyr-o-CRF from CRF1 receptor in rat frontal cortex homogenates |
Bioorg Med Chem Lett 16: 934-7 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.097
BindingDB Entry DOI: 10.7270/Q2J102Q5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50177572
(3-(4-(3-methoxybenzyloxy)phenylsulfonyl)-N-mesityl...)Show SMILES COc1cccc(COc2ccc(cc2)S(=O)(=O)c2ccc(C)nc2Nc2c(C)cc(C)cc2C)c1 Show InChI InChI=1S/C29H30N2O4S/c1-19-15-20(2)28(21(3)16-19)31-29-27(14-9-22(4)30-29)36(32,33)26-12-10-24(11-13-26)35-18-23-7-6-8-25(17-23)34-5/h6-17H,18H2,1-5H3,(H,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 58 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Tyr-o-CRF from CRF1 receptor in rat frontal cortex homogenates |
Bioorg Med Chem Lett 16: 934-7 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.097
BindingDB Entry DOI: 10.7270/Q2J102Q5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50074430
(1-(2-Bromo-4-isopropyl-phenyl)-4-chloro-6-methyl-1...)Show InChI InChI=1S/C17H16BrClN2/c1-10(2)12-4-5-16(14(18)9-12)21-7-6-13-15(19)8-11(3)20-17(13)21/h4-10H,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 67 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1 |
J Med Chem 42: 819-32 (1999)
Article DOI: 10.1021/jm980223o
BindingDB Entry DOI: 10.7270/Q22V2GT5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50177582
(3-((4-(2-(mesitylamino)-6-methylpyridin-3-ylsulfon...)Show SMILES Cc1cc(C)c(Nc2nc(C)ccc2S(=O)(=O)c2ccc(OCc3cccc(c3)C#N)cc2)c(C)c1 Show InChI InChI=1S/C29H27N3O3S/c1-19-14-20(2)28(21(3)15-19)32-29-27(13-8-22(4)31-29)36(33,34)26-11-9-25(10-12-26)35-18-24-7-5-6-23(16-24)17-30/h5-16H,18H2,1-4H3,(H,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 75 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]Tyr-o-CRF from CRF1 receptor in rat frontal cortex homogenates |
Bioorg Med Chem Lett 16: 934-7 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.097
BindingDB Entry DOI: 10.7270/Q2J102Q5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50074419
(1-(2-Bromo-4-isopropyl-phenyl)-6-chloro-4-methyl-1...)Show InChI InChI=1S/C17H16BrClN2/c1-10(2)12-4-5-15(14(18)9-12)21-7-6-13-11(3)8-16(19)20-17(13)21/h4-10H,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 79 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1 |
J Med Chem 42: 819-32 (1999)
Article DOI: 10.1021/jm980223o
BindingDB Entry DOI: 10.7270/Q22V2GT5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50074408
((2-Bromo-4-isopropyl-phenyl)-(4,6-dimethyl-pyrimid...)Show InChI InChI=1S/C16H20BrN3/c1-10(2)13-6-7-15(14(17)9-13)20(5)16-18-11(3)8-12(4)19-16/h6-10H,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 96 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1 |
J Med Chem 42: 819-32 (1999)
Article DOI: 10.1021/jm980223o
BindingDB Entry DOI: 10.7270/Q22V2GT5 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50074408
((2-Bromo-4-isopropyl-phenyl)-(4,6-dimethyl-pyrimid...)Show InChI InChI=1S/C16H20BrN3/c1-10(2)13-6-7-15(14(17)9-13)20(5)16-18-11(3)8-12(4)19-16/h6-10H,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 96 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description
Binding affinity of the compound was measured on rat Corticotropin releasing factor receptor 1 |
J Med Chem 42: 805-18 (1999)
Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50403726
(CHEMBL2112936)Show SMILES N[C@H]1CCCC[C@@H]1NC(=O)c1c2N[C@@H]3CCCC[C@H]3Nc2c2C(=O)c3ccccc3-c3ncnc1c23 Show InChI InChI=1S/C28H30N6O2/c29-16-9-3-4-10-17(16)34-28(36)22-24-20-21(25-26(22)33-19-12-6-5-11-18(19)32-25)27(35)15-8-2-1-7-14(15)23(20)30-13-31-24/h1-2,7-8,13,16-19,32-33H,3-6,9-12,29H2,(H,34,36)/t16-,17-,18+,19+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
A Subsidiary of Agouron Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 1 |
Bioorg Med Chem Lett 9: 765-70 (1999)
BindingDB Entry DOI: 10.7270/Q2TD9WJJ |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Rattus norvegicus (rat)) | BDBM50074423
(1-(2-Bromo-4-isopropyl-phenyl)-6-methyl-4-morpholi...)Show SMILES CC(C)c1ccc(c(Br)c1)-n1cc(C#N)c2c(cc(C)nc12)N1CCOCC1 Show InChI InChI=1S/C22H23BrN4O/c1-14(2)16-4-5-19(18(23)11-16)27-13-17(12-24)21-20(10-15(3)25-22(21)27)26-6-8-28-9-7-26/h4-5,10-11,13-14H,6-9H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 112 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company
Curated by ChEMBL
| Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1 |
J Med Chem 42: 819-32 (1999)
Article DOI: 10.1021/jm980223o
BindingDB Entry DOI: 10.7270/Q22V2GT5 |
More data for this
Ligand-Target Pair | |
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