Compile Data Set for Download or QSAR

Found 488 hits of ec50 for UniProtKB: P31422   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50094843 ((+)-2-Amino-6-fluoro-4-oxo-bicyclo[3.1.0]hexane-2,...) Show SMILES N[C@]1(CC(=O)[C@@H]2[C@H]1[C@@]2(F)C(O)=O)C(O)=O Show InChI InChI=1S/C8H8FNO5/c9-8(6(14)15)3-2(11)1-7(10,4(3)8)5(12)13/h3-4H,1,10H2,(H,12,13)(H,14,15)/t3-,4-,7+,8-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	2.07	n/a	n/a	n/a	n/a
Taisho Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Agonist potency against cloned Metabotropic glutamate receptor 3				J Med Chem 43: 4893-909 (2000) BindingDB Entry DOI: 10.7270/Q24J0DC8
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2/3 (Rattus norvegicus-Rattus norvegicus (Rat))	BDBM50056272 ((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...) Show SMILES N[C@]1(CC[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C8H11NO4/c9-8(7(12)13)2-1-3-4(5(3)8)6(10)11/h3-5H,1-2,9H2,(H,10,11)(H,12,13)/t3-,4-,5-,8-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	9.80	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at mGlu2/3 receptor in Sprague-Dawley rat forebrain assessed as inhibition of spontaneous Ca2+ oscillations in cortical neurons afte...				J Med Chem 61: 2303-2328 (2018) Article DOI: 10.1021/acs.jmedchem.7b01481 BindingDB Entry DOI: 10.7270/Q2W95CM9
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50138784 ((1R,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-hydroxy-...) Show SMILES N[C@@H]([C@H]1[C@@H](O)[C@@H]1C(O)=O)C(O)=O Show InChI InChI=1S/C6H9NO5/c7-3(6(11)12)1-2(4(1)8)5(9)10/h1-4,8H,7H2,(H,9,10)(H,11,12)/t1-,2+,3-,4+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
Lilly, SA Curated by ChEMBL					Assay Description Metabotropic glutamate receptor 3 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cells				J Med Chem 47: 456-66 (2004) Article DOI: 10.1021/jm030967o BindingDB Entry DOI: 10.7270/Q2K936Z5
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50138784 ((1R,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-hydroxy-...) Show SMILES N[C@@H]([C@H]1[C@@H](O)[C@@H]1C(O)=O)C(O)=O Show InChI InChI=1S/C6H9NO5/c7-3(6(11)12)1-2(4(1)8)5(9)10/h1-4,8H,7H2,(H,9,10)(H,11,12)/t1-,2+,3-,4+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
Lilly, SA Curated by ChEMBL					Assay Description Metabotropic glutamate receptor 3 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cells				J Med Chem 47: 456-66 (2004) Article DOI: 10.1021/jm030967o BindingDB Entry DOI: 10.7270/Q2K936Z5
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50397661 (EGLUMEGAD) Show SMILES N[C@]1(CC[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O Show InChI InChI=1S/C8H11NO4/c9-8(7(12)13)2-1-3-4(5(3)8)6(10)11/h3-5H,1-2,9H2,(H,10,11)(H,12,13)/t3-,4-,5-,8-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	38	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Agonist activity at mGLUR3 in rat cerebral cortex assessed as inhibition of forskolin-stimulated cAMP production				Bioorg Med Chem Lett 22: 1958-62 (2012) Article DOI: 10.1016/j.bmcl.2012.01.039 BindingDB Entry DOI: 10.7270/Q2T72JJ1
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50138781 ((1S,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-methyl-c...) Show SMILES C[C@@H]1[C@H]([C@H](N)C(O)=O)[C@H]1C(O)=O Show InChI InChI=1S/C7H11NO4/c1-2-3(4(2)6(9)10)5(8)7(11)12/h2-5H,8H2,1H3,(H,9,10)(H,11,12)/t2-,3+,4+,5+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	38	n/a	n/a	n/a	n/a
Lilly, SA Curated by ChEMBL					Assay Description Metabotropic glutamate receptor 3 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cells				J Med Chem 47: 456-66 (2004) Article DOI: 10.1021/jm030967o BindingDB Entry DOI: 10.7270/Q2K936Z5
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393885 (US10597367, Example 182 | US9969726, Example 182) Show SMILES Brc1ccc2N=C(CC(=O)Nc2c1)c1ccnc(c1)C#N |c:5| Show InChI InChI=1S/C15H9BrN4O/c16-10-1-2-12-14(6-10)20-15(21)7-13(19-12)9-3-4-18-11(5-9)8-17/h1-6H,7H2,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50094841 ((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...) Show SMILES N[C@@]1([C@H]2[C@@H](C[C@@H]1F)[C@@H]2C(O)=O)C(O)=O Show InChI InChI=1S/C8H10FNO4/c9-3-1-2-4(6(11)12)5(2)8(3,10)7(13)14/h2-5H,1,10H2,(H,11,12)(H,13,14)/t2-,3-,4-,5-,8-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	45.4	n/a	n/a	n/a	n/a
Taisho Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Agonist potency against cloned Metabotropic glutamate receptor 3				J Med Chem 43: 4893-909 (2000) BindingDB Entry DOI: 10.7270/Q24J0DC8
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393885 (US10597367, Example 182 | US9969726, Example 182) Show SMILES Brc1ccc2N=C(CC(=O)Nc2c1)c1ccnc(c1)C#N |c:5| Show InChI InChI=1S/C15H9BrN4O/c16-10-1-2-12-14(6-10)20-15(21)7-13(19-12)9-3-4-18-11(5-9)8-17/h1-6H,7H2,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM17657 ((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	58	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at rat mGlu3 receptor expressed in HEK293 cells by [35S]GTP-gamma binding assay				J Med Chem 59: 914-24 (2016) Article DOI: 10.1021/acs.jmedchem.5b01333 BindingDB Entry DOI: 10.7270/Q2000408
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM17657 ((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at rat mGlu3 receptor expressed in HEK293 cells by [35S]GTP-gamma binding assay				J Med Chem 59: 914-24 (2016) Article DOI: 10.1021/acs.jmedchem.5b01333 BindingDB Entry DOI: 10.7270/Q2000408
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393849 (US10597367, Example 137 | US9969726, Example 137) Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)S(=O)(=O)c1ncccn1 |c:4| Show InChI InChI=1S/C21H15F3N4O3S/c1-12-8-17-18(10-15(12)21(22,23)24)28-19(29)11-16(27-17)13-4-2-5-14(9-13)32(30,31)20-25-6-3-7-26-20/h2-10H,11H2,1H3,(H,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50056272 ((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...) Show SMILES N[C@]1(CC[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C8H11NO4/c9-8(7(12)13)2-1-3-4(5(3)8)6(10)11/h3-5H,1-2,9H2,(H,10,11)(H,12,13)/t3-,4-,5-,8-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	n/a	n/a	62.8	n/a	n/a	n/a	n/a
Taisho Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Agonist potency against cloned Metabotropic glutamate receptor 3				J Med Chem 43: 4893-909 (2000) BindingDB Entry DOI: 10.7270/Q24J0DC8
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393886 (US10597367, Example 183 | US9969726, Example 183) Show SMILES Ic1ccc2N=C(CC(=O)Nc2c1)c1ccnc(c1)C#N |c:5| Show InChI InChI=1S/C15H9IN4O/c16-10-1-2-12-14(6-10)20-15(21)7-13(19-12)9-3-4-18-11(5-9)8-17/h1-6H,7H2,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50576811 (CHEMBL4863303) Show SMILES Cc1ncc(OCCCCOc2ccc(C(=O)CC(C)(C)C)c(O)c2C)cc1C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	79	n/a	n/a	n/a	n/a
TBA					Assay Description Positive allosteric modulator activity at rat mGlu3 receptor transfected in GIRK channel overexpressing cells assessed as potentiation of glutamate-i...				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128342 BindingDB Entry DOI: 10.7270/Q22F7S71
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393834 (US10597367, Example 122 | US9969726, Example 122) Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccsc1 Show InChI InChI=1S/C22H12F4N2O2S/c23-17-5-4-13(9-16(17)21(29)30)12-2-1-3-14(8-12)20-27-18(15-6-7-31-11-15)10-19(28-20)22(24,25)26/h1-11H,(H,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	80	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50034503 ((1R,2R)-3-((S)-Amino-carboxy-methyl)-cyclopropane-...) Show SMILES N[C@@H](C1[C@H]([C@@H]1C(O)=O)C(O)=O)C(O)=O Show InChI InChI=1S/C7H9NO6/c8-4(7(13)14)1-2(5(9)10)3(1)6(11)12/h1-4H,8H2,(H,9,10)(H,11,12)(H,13,14)/t2-,3-,4+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	80	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at rat mGlu3 receptor by FRET based mGlu sensor assay				J Med Chem 59: 914-24 (2016) Article DOI: 10.1021/acs.jmedchem.5b01333 BindingDB Entry DOI: 10.7270/Q2000408
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50094842 ((+)-2-Amino-6-fluoro-bicyclo[3.1.0]hexane-2,6-dica...) Show SMILES N[C@]1(CC[C@@H]2[C@H]1[C@@]2(F)C(O)=O)C(O)=O Show InChI InChI=1S/C8H10FNO4/c9-8(6(13)14)3-1-2-7(10,4(3)8)5(11)12/h3-4H,1-2,10H2,(H,11,12)(H,13,14)/t3-,4-,7+,8-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	80.9	n/a	n/a	n/a	n/a
Taisho Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Agonist potency against cloned Metabotropic glutamate receptor 3				J Med Chem 43: 4893-909 (2000) BindingDB Entry DOI: 10.7270/Q24J0DC8
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50094841 ((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...) Show SMILES N[C@@]1([C@H]2[C@@H](C[C@@H]1F)[C@@H]2C(O)=O)C(O)=O Show InChI InChI=1S/C8H10FNO4/c9-3-1-2-4(6(11)12)5(2)8(3,10)7(13)14/h2-5H,1,10H2,(H,11,12)(H,13,14)/t2-,3-,4-,5-,8-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	97	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at rat mGlu3 receptor expressed in CHO cell membranes by GTPgammaS binding assay				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112521 BindingDB Entry DOI: 10.7270/Q2CR5Z03
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393882 (US10597367, Example 179 | US9969726, Example 179) Show SMILES Brc1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-c1cccnc1 |c:5| Show InChI InChI=1S/C20H14BrN3O/c21-16-6-7-17-19(10-16)24-20(25)11-18(23-17)14-4-1-3-13(9-14)15-5-2-8-22-12-15/h1-10,12H,11H2,(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50279772 (2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-cy...) Show SMILES N[C@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
Taisho Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Agonist potency against cloned Metabotropic glutamate receptor 3				J Med Chem 43: 4893-909 (2000) BindingDB Entry DOI: 10.7270/Q24J0DC8
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393797 (US10597367, Example 86 | US9969726, Example 86) Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccccc1 Show InChI InChI=1S/C24H14F4N2O2/c25-19-10-9-16(12-18(19)23(31)32)15-7-4-8-17(11-15)22-29-20(14-5-2-1-3-6-14)13-21(30-22)24(26,27)28/h1-13H,(H,31,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	120	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393848 (US10597367, Example 136 | US9969726, Example 136) Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(Sc2ncccn2)c1 |c:4| Show InChI InChI=1S/C21H15F3N4OS/c1-12-8-17-18(10-15(12)21(22,23)24)28-19(29)11-16(27-17)13-4-2-5-14(9-13)30-20-25-6-3-7-26-20/h2-10H,11H2,1H3,(H,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	120	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50576813 (CHEMBL4846460) Show SMILES Cc1c(O)c(ccc1OCCCCOc1ccc(Cl)c(c1)C(O)=O)C(=O)CC(C)(C)C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	130	n/a	n/a	n/a	n/a
TBA					Assay Description Positive allosteric modulator activity at rat mGlu3 receptor transfected in GIRK channel overexpressing cells assessed as potentiation of glutamate-i...				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128342 BindingDB Entry DOI: 10.7270/Q22F7S71
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393826 (US10597367, Example 114 | US9969726, Example 114) Show SMILES OC(=O)c1ccc(F)c(c1)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccoc1 Show InChI InChI=1S/C22H12F4N2O3/c23-17-5-4-14(21(29)30)9-16(17)12-2-1-3-13(8-12)20-27-18(15-6-7-31-11-15)10-19(28-20)22(24,25)26/h1-11H,(H,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	140	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393857 (US10597367, Example 149 | US9969726, Example 149) Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(Oc2ncccn2)c1 |c:4| Show InChI InChI=1S/C21H15F3N4O2/c1-12-8-17-18(10-15(12)21(22,23)24)28-19(29)11-16(27-17)13-4-2-5-14(9-13)30-20-25-6-3-7-26-20/h2-10H,11H2,1H3,(H,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	150	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50017268 (CHEMBL3287723 | US10099993, Compound 96) Show SMILES COc1ccc(cc1OCCCCOc1ccc(C(=O)CC(C)(C)C)c(O)c1C)C(O)=O Show InChI InChI=1S/C25H32O7/c1-16-20(11-9-18(23(16)27)19(26)15-25(2,3)4)31-12-6-7-13-32-22-14-17(24(28)29)8-10-21(22)30-5/h8-11,14,27H,6-7,12-13,15H2,1-5H3,(H,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	151	n/a	n/a	n/a	n/a
Sanford-Burnham Medical Research Institute Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...				J Med Chem 57: 4154-72 (2014) Article DOI: 10.1021/jm5000563 BindingDB Entry DOI: 10.7270/Q2GH9KH9
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393886 (US10597367, Example 183 | US9969726, Example 183) Show SMILES Ic1ccc2N=C(CC(=O)Nc2c1)c1ccnc(c1)C#N |c:5| Show InChI InChI=1S/C15H9IN4O/c16-10-1-2-12-14(6-10)20-15(21)7-13(19-12)9-3-4-18-11(5-9)8-17/h1-6H,7H2,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	160	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393894 (US10597367, Example 191 | US9969726, Example 191) Show SMILES FC(F)(F)c1ccc2N=C(CC(=O)Nc2c1)c1ccnc(Br)c1 |c:8| Show InChI InChI=1S/C15H9BrF3N3O/c16-13-5-8(3-4-20-13)11-7-14(23)22-12-6-9(15(17,18)19)1-2-10(12)21-11/h1-6H,7H2,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	180	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50576812 (CHEMBL4858387) Show SMILES Cc1c(OCCCCOc2cncc(c2)C(O)=O)ccc(C(=O)CC(C)(C)C)c1O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	180	n/a	n/a	n/a	n/a
TBA					Assay Description Positive allosteric modulator activity at rat mGlu3 receptor transfected in GIRK channel overexpressing cells assessed as potentiation of glutamate-i...				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128342 BindingDB Entry DOI: 10.7270/Q22F7S71
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50034503 ((1R,2R)-3-((S)-Amino-carboxy-methyl)-cyclopropane-...) Show SMILES N[C@@H](C1[C@H]([C@@H]1C(O)=O)C(O)=O)C(O)=O Show InChI InChI=1S/C7H9NO6/c8-4(7(13)14)1-2(5(9)10)3(1)6(11)12/h1-4H,8H2,(H,9,10)(H,11,12)(H,13,14)/t2-,3-,4+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a
Lilly, SA Curated by ChEMBL					Assay Description Metabotropic glutamate receptor 3 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cells				J Med Chem 47: 456-66 (2004) Article DOI: 10.1021/jm030967o BindingDB Entry DOI: 10.7270/Q2K936Z5
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393773 (US10597367, Example 62 | US9969726, Example 62) Show SMILES c1coc(c1)-c1cccc(c1)-c1nc(-c2ccccc2)n(n1)-c1ccccc1 Show InChI InChI=1S/C24H17N3O/c1-3-9-18(10-4-1)24-25-23(26-27(24)21-13-5-2-6-14-21)20-12-7-11-19(17-20)22-15-8-16-28-22/h1-17H	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	210	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393798 (US10597367, Example 87 | US9969726, Example 87) Show SMILES COc1ccc(cc1)-c1cc(nc(n1)-c1cccc(c1)-c1ccc(F)c(c1)C(O)=O)C(F)(F)F Show InChI InChI=1S/C25H16F4N2O3/c1-34-18-8-5-14(6-9-18)21-13-22(25(27,28)29)31-23(30-21)17-4-2-3-15(11-17)16-7-10-20(26)19(12-16)24(32)33/h2-13H,1H3,(H,32,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	250	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393801 (US10597367, Example 89 | US9969726, Example 89) Show SMILES OC(=O)c1cc(F)cc(c1)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccco1 Show InChI InChI=1S/C22H12F4N2O3/c23-16-9-14(8-15(10-16)21(29)30)12-3-1-4-13(7-12)20-27-17(18-5-2-6-31-18)11-19(28-20)22(24,25)26/h1-11H,(H,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	250	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393792 (US10597367, Example 81 | US9969726, Example 81) Show SMILES OC(=O)c1ccc(cc1)-c1ccc(cc1)-c1nc(cc(n1)C(F)(F)F)-c1ccc(nc1)C(F)(F)F Show InChI InChI=1S/C24H13F6N3O2/c25-23(26,27)19-10-9-17(12-31-19)18-11-20(24(28,29)30)33-21(32-18)15-5-1-13(2-6-15)14-3-7-16(8-4-14)22(34)35/h1-12H,(H,34,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	250	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50017271 (CHEMBL3287726 | US10099993, Compound 75) Show SMILES Cc1c(O)c(ccc1OCCCCOc1ccc(F)c(c1)C(O)=O)C(=O)CC(C)(C)C Show InChI InChI=1S/C24H29FO6/c1-15-21(10-8-17(22(15)27)20(26)14-24(2,3)4)31-12-6-5-11-30-16-7-9-19(25)18(13-16)23(28)29/h7-10,13,27H,5-6,11-12,14H2,1-4H3,(H,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	258	n/a	n/a	n/a	n/a
Sanford-Burnham Medical Research Institute Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...				J Med Chem 57: 4154-72 (2014) Article DOI: 10.1021/jm5000563 BindingDB Entry DOI: 10.7270/Q2GH9KH9
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393806 (US10597367, Example 94 | US9969726, Example 94) Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccoc1 Show InChI InChI=1S/C22H12F4N2O3/c23-17-5-4-13(9-16(17)21(29)30)12-2-1-3-14(8-12)20-27-18(15-6-7-31-11-15)10-19(28-20)22(24,25)26/h1-11H,(H,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	270	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393806 (US10597367, Example 94 | US9969726, Example 94) Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccoc1 Show InChI InChI=1S/C22H12F4N2O3/c23-17-5-4-13(9-16(17)21(29)30)12-2-1-3-14(8-12)20-27-18(15-6-7-31-11-15)10-19(28-20)22(24,25)26/h1-11H,(H,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	280	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393892 (US10597367, Example 189 | US9969726, Example 189) Show SMILES FC(F)(F)c1ccc2N=C(CC(=O)Nc2c1)c1ccnc(Cl)c1 |c:8| Show InChI InChI=1S/C15H9ClF3N3O/c16-13-5-8(3-4-20-13)11-7-14(23)22-12-6-9(15(17,18)19)1-2-10(12)21-11/h1-6H,7H2,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	280	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393829 (US10597367, Example 117 | US9969726, Example 117) Show SMILES Cc1cc(nc(n1)-c1cccc(c1)-c1ccc(F)c(c1)C(O)=O)-c1ccoc1 Show InChI InChI=1S/C22H15FN2O3/c1-13-9-20(17-7-8-28-12-17)25-21(24-13)16-4-2-3-14(10-16)15-5-6-19(23)18(11-15)22(26)27/h2-12H,1H3,(H,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	280	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50017270 (CHEMBL3287725 | US10099993, Compound 74) Show SMILES Cc1c(O)c(ccc1OCCCCOc1cccc(C(O)=O)c1C)C(=O)CC(C)(C)C Show InChI InChI=1S/C25H32O6/c1-16-18(24(28)29)9-8-10-21(16)30-13-6-7-14-31-22-12-11-19(23(27)17(22)2)20(26)15-25(3,4)5/h8-12,27H,6-7,13-15H2,1-5H3,(H,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a
Sanford-Burnham Medical Research Institute Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...				J Med Chem 57: 4154-72 (2014) Article DOI: 10.1021/jm5000563 BindingDB Entry DOI: 10.7270/Q2GH9KH9
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393849 (US10597367, Example 137 | US9969726, Example 137) Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)S(=O)(=O)c1ncccn1 |c:4| Show InChI InChI=1S/C21H15F3N4O3S/c1-12-8-17-18(10-15(12)21(22,23)24)28-19(29)11-16(27-17)13-4-2-5-14(9-13)32(30,31)20-25-6-3-7-26-20/h2-10H,11H2,1H3,(H,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50034503 ((1R,2R)-3-((S)-Amino-carboxy-methyl)-cyclopropane-...) Show SMILES N[C@@H](C1[C@H]([C@@H]1C(O)=O)C(O)=O)C(O)=O Show InChI InChI=1S/C7H9NO6/c8-4(7(13)14)1-2(5(9)10)3(1)6(11)12/h1-4H,8H2,(H,9,10)(H,11,12)(H,13,14)/t2-,3-,4+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a
CNS Research Curated by ChEMBL					Assay Description Concentration for half maximal activation of metabotropic glutamate mGluR3 in rat				J Med Chem 38: 1417-26 (1995) BindingDB Entry DOI: 10.7270/Q20R9Q1R
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50576814 (CHEMBL4875695) Show SMILES Cc1ccc(OCCCCOc2ccc(C(=O)CC(C)(C)C)c(O)c2C)cc1C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	309	n/a	n/a	n/a	n/a
TBA					Assay Description Positive allosteric modulator activity at rat mGlu3 receptor transfected in GIRK channel overexpressing cells assessed as potentiation of glutamate-i...				Citation and Details Article DOI: 10.1016/j.bmcl.2021.128342 BindingDB Entry DOI: 10.7270/Q22F7S71
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50017269 (CHEMBL3287724 | US10099993, Compound 73) Show SMILES COc1cc(ccc1OCCCCOc1ccc(C(=O)CC(C)(C)C)c(O)c1C)C(O)=O Show InChI InChI=1S/C25H32O7/c1-16-20(11-9-18(23(16)27)19(26)15-25(2,3)4)31-12-6-7-13-32-21-10-8-17(24(28)29)14-22(21)30-5/h8-11,14,27H,6-7,12-13,15H2,1-5H3,(H,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	310	n/a	n/a	n/a	n/a
Sanford-Burnham Medical Research Institute Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...				J Med Chem 57: 4154-72 (2014) Article DOI: 10.1021/jm5000563 BindingDB Entry DOI: 10.7270/Q2GH9KH9
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393906 (US10597367, Example 203 | US9969726, Example 203) Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)C#CCO |c:4| Show InChI InChI=1S/C20H15F3N2O2/c1-12-8-17-18(10-15(12)20(21,22)23)25-19(27)11-16(24-17)14-6-2-4-13(9-14)5-3-7-26/h2,4,6,8-10,26H,7,11H2,1H3,(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	320	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393845 (US10597367, Example 133 | US9969726, Example 133) Show SMILES Fc1ccc(cc1-c1noc(=O)[nH]1)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccoc1 Show InChI InChI=1S/C23H12F4N4O3/c24-17-5-4-13(9-16(17)21-30-22(32)34-31-21)12-2-1-3-14(8-12)20-28-18(15-6-7-33-11-15)10-19(29-20)23(25,26)27/h1-11H,(H,30,31,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	330	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393780 (US10597367, Example 69 | US9969726, Example 69) Show SMILES OC(=O)c1cccc(c1)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccc(nc1)C(F)(F)F Show InChI InChI=1S/C24H13F6N3O2/c25-23(26,27)19-8-7-17(12-31-19)18-11-20(24(28,29)30)33-21(32-18)15-5-1-3-13(9-15)14-4-2-6-16(10-14)22(34)35/h1-12H,(H,34,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	340	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393831 (US10597367, Example 119 | US9969726, Example 119) Show SMILES Cc1cc(nc(n1)-c1cccc(c1)-c1cccc(c1)C(O)=O)-c1ccoc1 Show InChI InChI=1S/C22H16N2O3/c1-14-10-20(19-8-9-27-13-19)24-21(23-14)17-6-2-4-15(11-17)16-5-3-7-18(12-16)22(25)26/h2-13H,1H3,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	350	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393857 (US10597367, Example 149 | US9969726, Example 149) Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(Oc2ncccn2)c1 |c:4| Show InChI InChI=1S/C21H15F3N4O2/c1-12-8-17-18(10-15(12)21(22,23)24)28-19(29)11-16(27-17)13-4-2-5-14(9-13)30-20-25-6-3-7-26-20/h2-10H,11H2,1H3,(H,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	370	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair

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