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Compile Data Set for Download or QSAR

Found 72 hits of ec50 for UniProtKB: P49336   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50248686
PNG
(CHEMBL4071040)
Show SMILES COCCNC(=O)c1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)c(C)n1
Show InChI InChI=1S/C20H20N4O4S2/c1-10-14(6-5-13(24-10)19(26)22-7-8-27-2)28-20-15-12(17(29-20)18(21)25)4-3-11-9-23-30-16(11)15/h5-6,9H,3-4,7-8H2,1-2H3,(H2,21,25)(H,22,26)
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n/an/an/an/a 0.350n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards HSV-1 thymidine kinase

Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50248656
PNG
(CHEMBL4086487)
Show SMILES CC(=O)Nc1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1
Show InChI InChI=1S/C17H14N4O3S2/c1-8(22)21-12-5-3-10(7-19-12)24-17-13-11(15(25-17)16(18)23)4-2-9-6-20-26-14(9)13/h3,5-7H,2,4H2,1H3,(H2,18,23)(H,19,21,22)
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n/an/an/an/a 0.400n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727 after 2 hrs by Western blot method

Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50248645
PNG
(CHEMBL4061525)
Show SMILES CNc1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1
Show InChI InChI=1S/C16H14N4O2S2/c1-18-11-5-3-9(7-19-11)22-16-12-10(14(23-16)15(17)21)4-2-8-6-20-24-13(8)12/h3,5-7H,2,4H2,1H3,(H2,17,21)(H,18,19)
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n/an/an/an/a 0.580n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727 after 2 hrs by Western blot method

Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50248633
PNG
(CHEMBL4083552)
Show SMILES NC(=O)c1sc(Oc2ccccc2)c-2c1CCc1cnsc-21
Show InChI InChI=1S/C16H12N2O2S2/c17-15(19)14-11-7-6-9-8-18-22-13(9)12(11)16(21-14)20-10-4-2-1-3-5-10/h1-5,8H,6-7H2,(H2,17,19)
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n/an/an/an/a 0.770n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727 after 2 hrs by Western blot method

Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50248614
PNG
(CHEMBL4066819)
Show SMILES COCCNC(=O)c1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1
Show InChI InChI=1S/C19H18N4O4S2/c1-26-7-6-21-18(25)13-5-3-11(9-22-13)27-19-14-12(16(28-19)17(20)24)4-2-10-8-23-29-15(10)14/h3,5,8-9H,2,4,6-7H2,1H3,(H2,20,24)(H,21,25)
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n/an/an/an/a 1.30n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727 after 2 hrs by Western blot method

Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50248611
PNG
(CHEMBL4060856)
Show SMILES NC(=O)c1sc(Oc2ccc(nc2)C(N)=O)c-2c1CCc1cnsc-21
Show InChI InChI=1S/C16H12N4O3S2/c17-14(21)10-4-2-8(6-19-10)23-16-11-9(13(24-16)15(18)22)3-1-7-5-20-25-12(7)11/h2,4-6H,1,3H2,(H2,17,21)(H2,18,22)
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n/an/an/an/a 1.40n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727 after 2 hrs by Western blot method

Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50248615
PNG
(CHEMBL4077627)
Show SMILES CCOCCNC(=O)c1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1
Show InChI InChI=1S/C20H20N4O4S2/c1-2-27-8-7-22-19(26)14-6-4-12(10-23-14)28-20-15-13(17(29-20)18(21)25)5-3-11-9-24-30-16(11)15/h4,6,9-10H,2-3,5,7-8H2,1H3,(H2,21,25)(H,22,26)
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n/an/an/an/a 1.5n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727 after 2 hrs by Western blot method

Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50248635
PNG
(CHEMBL4070408)
Show SMILES Cc1ncccc1Oc1sc(C(N)=O)c2CCc3cnsc3-c12
Show InChI InChI=1S/C16H13N3O2S2/c1-8-11(3-2-6-18-8)21-16-12-10(14(22-16)15(17)20)5-4-9-7-19-23-13(9)12/h2-3,6-7H,4-5H2,1H3,(H2,17,20)
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n/an/an/an/a 2n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727 after 2 hrs by Western blot method

Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50248640
PNG
(CHEMBL4074204)
Show SMILES NC(=O)c1sc(Oc2ccc(N)nc2)c-2c1CCc1cnsc-21
Show InChI InChI=1S/C15H12N4O2S2/c16-10-4-2-8(6-18-10)21-15-11-9(13(22-15)14(17)20)3-1-7-5-19-23-12(7)11/h2,4-6H,1,3H2,(H2,16,18)(H2,17,20)
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n/an/an/an/a 2.30n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727 after 2 hrs by Western blot method

Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50241885
PNG
(CHEMBL4060759)
Show SMILES Fc1cncc(\C=C\C(=O)Nc2ccc(CN3CCOCC3)cc2)c1-c1cnn(c1)C1CC1
Show InChI InChI=1S/C25H26FN5O2/c26-23-15-27-13-19(25(23)20-14-28-31(17-20)22-6-7-22)3-8-24(32)29-21-4-1-18(2-5-21)16-30-9-11-33-12-10-30/h1-5,8,13-15,17,22H,6-7,9-12,16H2,(H,29,32)/b8-3+
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n/an/an/an/a 2.30n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...

Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50241892
PNG
(CHEMBL4072106)
Show SMILES Cn1cnc2ccc(cc12)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C27H27N5O2/c1-31-19-29-25-8-4-21(16-26(25)31)24-10-11-28-17-22(24)5-9-27(33)30-23-6-2-20(3-7-23)18-32-12-14-34-15-13-32/h2-11,16-17,19H,12-15,18H2,1H3,(H,30,33)/b9-5+
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n/an/an/an/a 2.40n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...

Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50248612
PNG
(CHEMBL4076395)
Show SMILES CNC(=O)c1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1
Show InChI InChI=1S/C17H14N4O3S2/c1-19-16(23)11-5-3-9(7-20-11)24-17-12-10(14(25-17)15(18)22)4-2-8-6-21-26-13(8)12/h3,5-7H,2,4H2,1H3,(H2,18,22)(H,19,23)
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n/an/an/an/a 2.60n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards HSV-1 thymidine kinase

Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50248638
PNG
(CHEMBL4062244)
Show SMILES Cc1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1
Show InChI InChI=1S/C16H13N3O2S2/c1-8-2-4-10(7-18-8)21-16-12-11(14(22-16)15(17)20)5-3-9-6-19-23-13(9)12/h2,4,6-7H,3,5H2,1H3,(H2,17,20)
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n/an/an/an/a 3n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727 after 2 hrs by Western blot method

Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50248662
PNG
(CHEMBL4091345)
Show SMILES NC(=O)c1sc(Oc2cccnc2)c-2c1CCc1cnsc-21
Show InChI InChI=1S/C15H11N3O2S2/c16-14(19)13-10-4-3-8-6-18-22-12(8)11(10)15(21-13)20-9-2-1-5-17-7-9/h1-2,5-7H,3-4H2,(H2,16,19)
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n/an/an/an/a 3n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727 after 2 hrs by Western blot method

Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50241859
PNG
(CHEMBL4063908)
Show SMILES O=C(Nc1ccc(CN2CC3CC2CO3)cc1)\C=C\c1cnccc1-c1cnn(c1)C1CC1
Show InChI InChI=1S/C26H27N5O2/c32-26(29-21-4-1-18(2-5-21)14-30-16-24-11-23(30)17-33-24)8-3-19-12-27-10-9-25(19)20-13-28-31(15-20)22-6-7-22/h1-5,8-10,12-13,15,22-24H,6-7,11,14,16-17H2,(H,29,32)/b8-3+
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n/an/an/an/a 3.10n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of [3H]mazindol binding to Norepinephrine transporter

Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50241896
PNG
(CHEMBL4081088)
Show SMILES Cn1cc(cn1)-c1c(F)cncc1\C=C\C(=O)Nc1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C23H24FN5O2/c1-28-16-19(13-26-28)23-18(12-25-14-21(23)24)4-7-22(30)27-20-5-2-17(3-6-20)15-29-8-10-31-11-9-29/h2-7,12-14,16H,8-11,15H2,1H3,(H,27,30)/b7-4+
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n/an/an/an/a 3.60n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...

Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50241860
PNG
(CHEMBL4079977)
Show SMILES O=C(Nc1ccc(CN2CC3CC(C2)O3)cc1)\C=C\c1cnccc1-c1cnn(c1)C1CC1
Show InChI InChI=1S/C26H27N5O2/c32-26(29-21-4-1-18(2-5-21)14-30-16-23-11-24(17-30)33-23)8-3-19-12-27-10-9-25(19)20-13-28-31(15-20)22-6-7-22/h1-5,8-10,12-13,15,22-24H,6-7,11,14,16-17H2,(H,29,32)/b8-3+
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n/an/an/an/a 5.5n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...

Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50241863
PNG
(CHEMBL4060561)
Show SMILES Cn1cc(cn1)-c1ccncc1\C=C\C(=O)Nc1ccc2CN(CC(F)(F)F)CCc2c1
Show InChI InChI=1S/C23H22F3N5O/c1-30-13-19(12-28-30)21-6-8-27-11-17(21)3-5-22(32)29-20-4-2-18-14-31(15-23(24,25)26)9-7-16(18)10-20/h2-6,8,10-13H,7,9,14-15H2,1H3,(H,29,32)/b5-3+
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n/an/an/an/a 7n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...

Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50248687
PNG
(CHEMBL4090775)
Show SMILES CC(C)(O)CNC(=O)c1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1
Show InChI InChI=1S/C20H20N4O4S2/c1-20(2,27)9-23-18(26)13-6-4-11(8-22-13)28-19-14-12(16(29-19)17(21)25)5-3-10-7-24-30-15(10)14/h4,6-8,27H,3,5,9H2,1-2H3,(H2,21,25)(H,23,26)
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n/an/an/an/a 7.40n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards HSV-1 thymidine kinase

Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50248609
PNG
(CHEMBL4088931)
Show SMILES Cc1c(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)ccc[n+]1[O-]
Show InChI InChI=1S/C16H13N3O3S2/c1-8-11(3-2-6-19(8)21)22-16-12-10(14(23-16)15(17)20)5-4-9-7-18-24-13(9)12/h2-3,6-7H,4-5H2,1H3,(H2,17,20)
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n/an/an/an/a 8.30n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727 after 2 hrs by Western blot method

Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50241864
PNG
(CHEMBL4069244)
Show SMILES Cn1cc(cn1)-c1ccncc1\C=C\C(=O)Nc1ccc2CCN(CC(F)(F)F)Cc2c1
Show InChI InChI=1S/C23H22F3N5O/c1-30-13-19(12-28-30)21-6-8-27-11-17(21)3-5-22(32)29-20-4-2-16-7-9-31(14-18(16)10-20)15-23(24,25)26/h2-6,8,10-13H,7,9,14-15H2,1H3,(H,29,32)/b5-3+
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n/an/an/an/a 8.40n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...

Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50241862
PNG
(CHEMBL4059523)
Show SMILES FC1(F)CN(Cc2ccc(NC(=O)\C=C\c3cnccc3-c3cnn(c3)C3CC3)cc2)C1
Show InChI InChI=1S/C24H23F2N5O/c25-24(26)15-30(16-24)13-17-1-4-20(5-2-17)29-23(32)8-3-18-11-27-10-9-22(18)19-12-28-31(14-19)21-6-7-21/h1-5,8-12,14,21H,6-7,13,15-16H2,(H,29,32)/b8-3+
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n/an/an/an/a 8.40n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...

Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50248690
PNG
(CHEMBL4082469)
Show SMILES CSc1sc(C(N)=O)c2CCc3cnsc3-c12
Show InChI InChI=1S/C11H10N2OS3/c1-15-11-7-6(9(16-11)10(12)14)3-2-5-4-13-17-8(5)7/h4H,2-3H2,1H3,(H2,12,14)
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n/an/an/an/a 8.90n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727 after 2 hrs by Western blot method

Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50248632
PNG
(CHEMBL4069854)
Show SMILES COc1sc(C(N)=O)c2CCc3cnsc3-c12
Show InChI InChI=1S/C11H10N2O2S2/c1-15-11-7-6(9(16-11)10(12)14)3-2-5-4-13-17-8(5)7/h4H,2-3H2,1H3,(H2,12,14)
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n/an/an/an/a 9.10n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727 after 2 hrs by Western blot method

Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50241879
PNG
(CHEMBL4082587)
Show SMILES O=C(Nc1ccc(CN2CCOCC2)cc1)\C=C\c1cnccc1-c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C26H25N5O2/c32-26(30-22-5-1-19(2-6-22)17-31-11-13-33-14-12-31)8-4-21-16-27-10-9-23(21)20-3-7-24-25(15-20)29-18-28-24/h1-10,15-16,18H,11-14,17H2,(H,28,29)(H,30,32)/b8-4+
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n/an/an/an/a 10n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...

Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50241881
PNG
(CHEMBL4063489)
Show SMILES FC(F)n1cc(cn1)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C23H23F2N5O2/c24-23(25)30-16-19(14-27-30)21-7-8-26-13-18(21)3-6-22(31)28-20-4-1-17(2-5-20)15-29-9-11-32-12-10-29/h1-8,13-14,16,23H,9-12,15H2,(H,28,31)/b6-3+
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n/an/an/an/a 11n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...

Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50241868
PNG
(CHEMBL4092865)
Show SMILES O=C(Nc1ccc(CN2CCOCC2)cc1)\C=C\c1cnccc1-c1cnn(c1)C1CC1
Show InChI InChI=1S/C25H27N5O2/c31-25(28-22-4-1-19(2-5-22)17-29-11-13-32-14-12-29)8-3-20-15-26-10-9-24(20)21-16-27-30(18-21)23-6-7-23/h1-5,8-10,15-16,18,23H,6-7,11-14,17H2,(H,28,31)/b8-3+
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n/an/an/an/a 11n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...

Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50241871
PNG
(CHEMBL4087219)
Show SMILES COc1ncc(s1)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C23H24N4O3S/c1-29-23-25-15-21(31-23)20-8-9-24-14-18(20)4-7-22(28)26-19-5-2-17(3-6-19)16-27-10-12-30-13-11-27/h2-9,14-15H,10-13,16H2,1H3,(H,26,28)/b7-4+
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n/an/an/an/a 12n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...

Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50241866
PNG
(CHEMBL4063709)
Show SMILES Cn1cc(cn1)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C23H25N5O2/c1-27-17-20(15-25-27)22-8-9-24-14-19(22)4-7-23(29)26-21-5-2-18(3-6-21)16-28-10-12-30-13-11-28/h2-9,14-15,17H,10-13,16H2,1H3,(H,26,29)/b7-4+
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n/an/an/an/a 13n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...

Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50241891
PNG
(CHEMBL4082444)
Show SMILES FC(F)(F)CN1CCc2cc(NC(=O)\C=C\c3cnccc3-c3cnn(c3)C3CC3)ccc2C1
Show InChI InChI=1S/C25H24F3N5O/c26-25(27,28)16-32-10-8-17-11-21(3-1-19(17)14-32)31-24(34)6-2-18-12-29-9-7-23(18)20-13-30-33(15-20)22-4-5-22/h1-3,6-7,9,11-13,15,22H,4-5,8,10,14,16H2,(H,31,34)/b6-2+
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n/an/an/an/a 14n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...

Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50248658
PNG
(CHEMBL4060714)
Show SMILES Cc1ccncc1Oc1sc(C(N)=O)c2CCc3cnsc3-c12
Show InChI InChI=1S/C16H13N3O2S2/c1-8-4-5-18-7-11(8)21-16-12-10(14(22-16)15(17)20)3-2-9-6-19-23-13(9)12/h4-7H,2-3H2,1H3,(H2,17,20)
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n/an/an/an/a 16n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727 after 2 hrs by Western blot method

Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50241857
PNG
(CHEMBL4091382)
Show SMILES CC1CN(Cc2ccc(NC(=O)\C=C\c3cnccc3-c3cnn(C)c3)cc2)CCO1
Show InChI InChI=1S/C24H27N5O2/c1-18-15-29(11-12-31-18)16-19-3-6-22(7-4-19)27-24(30)8-5-20-13-25-10-9-23(20)21-14-26-28(2)17-21/h3-10,13-14,17-18H,11-12,15-16H2,1-2H3,(H,27,30)/b8-5+
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n/an/an/an/a 16n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...

Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50241858
PNG
(CHEMBL4070459)
Show SMILES Cn1cc(cn1)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2C3CCC2COC3)cc1
Show InChI InChI=1S/C25H27N5O2/c1-29-15-20(13-27-29)24-10-11-26-12-19(24)4-9-25(31)28-21-5-2-18(3-6-21)14-30-22-7-8-23(30)17-32-16-22/h2-6,9-13,15,22-23H,7-8,14,16-17H2,1H3,(H,28,31)/b9-4+
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n/an/an/an/a 17n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of [3H]WIN-35428l binding to Dopamine transporter

Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50241890
PNG
(CHEMBL4098004)
Show SMILES Cn1cc(cn1)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2CCC(F)(F)C2)cc1
Show InChI InChI=1S/C23H23F2N5O/c1-29-15-19(13-27-29)21-8-10-26-12-18(21)4-7-22(31)28-20-5-2-17(3-6-20)14-30-11-9-23(24,25)16-30/h2-8,10,12-13,15H,9,11,14,16H2,1H3,(H,28,31)/b7-4+
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n/an/an/an/a 17n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of [3H]paroxetine binding to Serotonin transporter

Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50241900
PNG
(CHEMBL4066959)
Show SMILES Cn1cc(cn1)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2CC3CC2CO3)cc1
Show InChI InChI=1S/C24H25N5O2/c1-28-14-19(12-26-28)23-8-9-25-11-18(23)4-7-24(30)27-20-5-2-17(3-6-20)13-29-15-22-10-21(29)16-31-22/h2-9,11-12,14,21-22H,10,13,15-16H2,1H3,(H,27,30)/b7-4+
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n/an/an/an/a 19n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...

Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50241875
PNG
(CHEMBL4091527)
Show SMILES O=C(Nc1ccc(CN2CCOCC2)cc1)\C=C\c1cnccc1-c1cn[nH]c1
Show InChI InChI=1S/C22H23N5O2/c28-22(6-3-18-13-23-8-7-21(18)19-14-24-25-15-19)26-20-4-1-17(2-5-20)16-27-9-11-29-12-10-27/h1-8,13-15H,9-12,16H2,(H,24,25)(H,26,28)/b6-3+
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n/an/an/an/a 21n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...

Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50248613
PNG
(CHEMBL4063680)
Show SMILES CN(C)C(=O)c1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1
Show InChI InChI=1S/C18H16N4O3S2/c1-22(2)17(24)12-6-4-10(8-20-12)25-18-13-11(15(26-18)16(19)23)5-3-9-7-21-27-14(9)13/h4,6-8H,3,5H2,1-2H3,(H2,19,23)
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n/an/an/an/a 21n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727 after 2 hrs by Western blot method

Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50593061
PNG
(CHEMBL5183704)
Show SMILES Cc1ccc(NC(=O)CCc2cccc(c2)-c2cnc3[nH]ccc3c2)cc1C(F)(F)F
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n/an/an/an/a 24n/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c00820
BindingDB Entry DOI: 10.7270/Q25X2DX9
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50248608
PNG
(CHEMBL4063358)
Show SMILES CSc1sc(C(N)=O)c2CCc3cnn(C)c3-c12
Show InChI InChI=1S/C12H13N3OS2/c1-15-9-6(5-14-15)3-4-7-8(9)12(17-2)18-10(7)11(13)16/h5H,3-4H2,1-2H3,(H2,13,16)
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n/an/an/an/a 25n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727 after 2 hrs by Western blot method

Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50241897
PNG
(CHEMBL4061835)
Show SMILES CC1COCCN1Cc1ccc(NC(=O)\C=C\c2cnccc2-c2cnn(C)c2)cc1
Show InChI InChI=1S/C24H27N5O2/c1-18-17-31-12-11-29(18)15-19-3-6-22(7-4-19)27-24(30)8-5-20-13-25-10-9-23(20)21-14-26-28(2)16-21/h3-10,13-14,16,18H,11-12,15,17H2,1-2H3,(H,27,30)/b8-5+
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n/an/an/an/a 27n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...

Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50248639
PNG
(CHEMBL4072372)
Show SMILES Cc1cncc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)c1
Show InChI InChI=1S/C16H13N3O2S2/c1-8-4-10(7-18-5-8)21-16-12-11(14(22-16)15(17)20)3-2-9-6-19-23-13(9)12/h4-7H,2-3H2,1H3,(H2,17,20)
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n/an/an/an/a 28n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727 after 2 hrs by Western blot method

Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50241882
PNG
(CHEMBL4101552)
Show SMILES O=C(Nc1ccc(CN2CCOCC2)cc1)\C=C\c1cnccc1-c1cnn(Cc2ccccc2)c1
Show InChI InChI=1S/C29H29N5O2/c35-29(32-27-9-6-24(7-10-27)20-33-14-16-36-17-15-33)11-8-25-18-30-13-12-28(25)26-19-31-34(22-26)21-23-4-2-1-3-5-23/h1-13,18-19,22H,14-17,20-21H2,(H,32,35)/b11-8+
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n/an/an/an/a 28n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...

Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50248634
PNG
(CHEMBL4061783)
Show SMILES NC(=O)c1sc(Oc2ccccn2)c-2c1CCc1cnsc-21
Show InChI InChI=1S/C15H11N3O2S2/c16-14(19)13-9-5-4-8-7-18-22-12(8)11(9)15(21-13)20-10-3-1-2-6-17-10/h1-3,6-7H,4-5H2,(H2,16,19)
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n/an/an/an/a 66n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727 after 2 hrs by Western blot method

Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50248705
PNG
(CHEMBL4102907)
Show SMILES C[S+]([O-])c1sc(C(N)=O)c2CCc3cnsc3-c12
Show InChI InChI=1S/C11H10N2O2S3/c1-18(15)11-7-6(9(16-11)10(12)14)3-2-5-4-13-17-8(5)7/h4H,2-3H2,1H3,(H2,12,14)
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n/an/an/an/a 70n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727 after 2 hrs by Western blot method

Bioorg Med Chem 25: 2336-2350 (2017)


Article DOI: 10.1016/j.bmc.2017.02.038
BindingDB Entry DOI: 10.7270/Q21J9D6H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50241861
PNG
(CHEMBL4087859)
Show SMILES Cn1cc(cn1)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2CC(F)(F)C2)cc1
Show InChI InChI=1S/C22H21F2N5O/c1-28-13-18(11-26-28)20-8-9-25-10-17(20)4-7-21(30)27-19-5-2-16(3-6-19)12-29-14-22(23,24)15-29/h2-11,13H,12,14-15H2,1H3,(H,27,30)/b7-4+
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n/an/an/an/a 84n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...

Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50241895
PNG
(CHEMBL4074871)
Show SMILES Cn1cc(cn1)-c1ccncc1CCC(=O)Nc1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C23H27N5O2/c1-27-17-20(15-25-27)22-8-9-24-14-19(22)4-7-23(29)26-21-5-2-18(3-6-21)16-28-10-12-30-13-11-28/h2-3,5-6,8-9,14-15,17H,4,7,10-13,16H2,1H3,(H,26,29)
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n/an/an/an/a 95n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...

Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50241872
PNG
(CHEMBL4097361)
Show SMILES COc1ccc(s1)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C24H25N3O3S/c1-29-24-9-7-22(31-24)21-10-11-25-16-19(21)4-8-23(28)26-20-5-2-18(3-6-20)17-27-12-14-30-15-13-27/h2-11,16H,12-15,17H2,1H3,(H,26,28)/b8-4+
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n/an/an/an/a 97n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...

Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50241889
PNG
(CHEMBL4083599)
Show SMILES Cn1cc(cn1)-c1ccncc1\C=C\C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H16N4O/c1-22-13-15(12-20-22)17-9-10-19-11-14(17)7-8-18(23)21-16-5-3-2-4-6-16/h2-13H,1H3,(H,21,23)/b8-7+
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n/an/an/an/a 110n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...

Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50241870
PNG
(CHEMBL4094902)
Show SMILES O=C(Nc1ccc(CN2CCOCC2)cc1)\C=C\c1cnccc1-c1cnsc1
Show InChI InChI=1S/C22H22N4O2S/c27-22(6-3-18-13-23-8-7-21(18)19-14-24-29-16-19)25-20-4-1-17(2-5-20)15-26-9-11-28-12-10-26/h1-8,13-14,16H,9-12,15H2,(H,25,27)/b6-3+
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n/an/an/an/a 110n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...

Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))		BDBM50241869
PNG
(CHEMBL4093832)
Show SMILES O=C(CCc1cnccc1-c1cnn(c1)C1CC1)Nc1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C25H29N5O2/c31-25(28-22-4-1-19(2-5-22)17-29-11-13-32-14-12-29)8-3-20-15-26-10-9-24(20)21-16-27-30(18-21)23-6-7-23/h1-2,4-5,9-10,15-16,18,23H,3,6-8,11-14,17H2,(H,28,31)
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n/an/an/an/a 130n/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...

Bioorg Med Chem 25: 3018-3033 (2017)


Article DOI: 10.1016/j.bmc.2017.03.049
BindingDB Entry DOI: 10.7270/Q24X59XW
More data for this
Ligand-Target Pair
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