Found 17 hits of kd for UniProtKB: P05089 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Arginase-1
(Homo sapiens (Human)) | BDBM50350311
(CHEMBL1812661)Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to human Arg1 at pH 8.5 |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115658 BindingDB Entry DOI: 10.7270/Q2WS8XZC |
More data for this Ligand-Target Pair | |
Arginase-1
(Homo sapiens (Human)) | BDBM50350311
(CHEMBL1812661)Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| | n/a | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Arginase-1
(Homo sapiens (Human)) | BDBM50350311
(CHEMBL1812661)Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| | n/a | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Arginase-1
(Homo sapiens (Human)) | BDBM50350311
(CHEMBL1812661)Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a |
Drexel University
Curated by ChEMBL
| Assay Description Binding affinity to human arginase 1 |
J Med Chem 54: 5432-43 (2011)
Article DOI: 10.1021/jm200443b BindingDB Entry DOI: 10.7270/Q2TH8N21 |
More data for this Ligand-Target Pair | |
Arginase-1
(Homo sapiens (Human)) | BDBM50350311
(CHEMBL1812661)Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a |
Drexel University
Curated by ChEMBL
| Assay Description Binding affinity to human arginase 1 using L-arginine as substrate by surface plasmon resonance assay |
J Med Chem 54: 5432-43 (2011)
Article DOI: 10.1021/jm200443b BindingDB Entry DOI: 10.7270/Q2TH8N21 |
More data for this Ligand-Target Pair | |
Arginase-1
(Homo sapiens (Human)) | BDBM50008099
(CHEMBL1234777)Show InChI InChI=1S/C5H12N4O3/c6-3(4(10)11)1-2-8-5(7)9-12/h3,12H,1-2,6H2,(H,10,11)(H3,7,8,9)/t3-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to arginase 1 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2017.12.044 BindingDB Entry DOI: 10.7270/Q2736THR |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Arginase-1
(Homo sapiens (Human)) | BDBM50008099
(CHEMBL1234777)Show InChI InChI=1S/C5H12N4O3/c6-3(4(10)11)1-2-8-5(7)9-12/h3,12H,1-2,6H2,(H,10,11)(H3,7,8,9)/t3-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB
| n/a | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Arginase-1
(Homo sapiens (Human)) | BDBM50561034
(CHEMBL4244287) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE KEGG PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to human Arg1 at pH 8.5 |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115658 BindingDB Entry DOI: 10.7270/Q2WS8XZC |
More data for this Ligand-Target Pair | |
Arginase-1
(Homo sapiens (Human)) | BDBM50008099
(CHEMBL1234777)Show InChI InChI=1S/C5H12N4O3/c6-3(4(10)11)1-2-8-5(7)9-12/h3,12H,1-2,6H2,(H,10,11)(H3,7,8,9)/t3-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | 517 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to human Arg1 at pH 8.5 |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115658 BindingDB Entry DOI: 10.7270/Q2WS8XZC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Arginase-1
(Homo sapiens (Human)) | BDBM50350309
(CHEMBL1812662)Show InChI InChI=1S/C7H16BNO4/c1-7(9,6(10)11)4-2-3-5-8(12)13/h12-13H,2-5,9H2,1H3,(H,10,11) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 880 | n/a | n/a | n/a | n/a | n/a |
Drexel University
Curated by ChEMBL
| Assay Description Binding affinity to human arginase 1 using L-arginine as substrate by surface plasmon resonance assay |
J Med Chem 54: 5432-43 (2011)
Article DOI: 10.1021/jm200443b BindingDB Entry DOI: 10.7270/Q2TH8N21 |
More data for this Ligand-Target Pair | |
Arginase-1
(Homo sapiens (Human)) | BDBM50350309
(CHEMBL1812662)Show InChI InChI=1S/C7H16BNO4/c1-7(9,6(10)11)4-2-3-5-8(12)13/h12-13H,2-5,9H2,1H3,(H,10,11) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| | n/a | n/a | n/a | 880 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Arginase-1
(Homo sapiens (Human)) | BDBM50316603
(2-(S)-amino-5-(2-aminoimidazol-1-yl)pentanoic acid...)Show InChI InChI=1S/C8H14N4O2/c9-6(7(13)14)2-1-4-12-5-3-11-8(12)10/h3,5-6H,1-2,4,9H2,(H2,10,11)(H,13,14)/t6-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a |
University of Pennsylvania
Curated by ChEMBL
| Assay Description Inhibition of human recombinant full length arginase 1 expressed in Escherichia coli BL21(DE3) by surface plasmon resonance assay |
J Med Chem 53: 4266-76 (2010)
Article DOI: 10.1021/jm100306a BindingDB Entry DOI: 10.7270/Q2SQ90JK |
More data for this Ligand-Target Pair | |
Arginase-1
(Homo sapiens (Human)) | BDBM50230418
(CHEMBL260629 | N(gamma)-hydroxy-L-arginine | N-OME...)Show SMILES NC(NO)=NCCC[C@H]([NH3+])C([O-])=O |r,w:4.4| Show InChI InChI=1S/C6H14N4O3/c7-4(5(11)12)2-1-3-9-6(8)10-13/h4,13H,1-3,7H2,(H,11,12)(H3,8,9,10)/t4-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid UniChem
Similars
| MMDB Article PubMed
| n/a | n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to human Arg1 at pH 8.5 |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115658 BindingDB Entry DOI: 10.7270/Q2WS8XZC |
More data for this Ligand-Target Pair | |
Arginase-1
(Homo sapiens (Human)) | BDBM50350310
(CHEMBL1812663)Show InChI InChI=1S/C7H14BF2NO4/c9-5(10)7(11,6(12)13)3-1-2-4-8(14)15/h5,14-15H,1-4,11H2,(H,12,13) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
| | n/a | n/a | n/a | 3.40E+4 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Arginase-1
(Homo sapiens (Human)) | BDBM50350310
(CHEMBL1812663)Show InChI InChI=1S/C7H14BF2NO4/c9-5(10)7(11,6(12)13)3-1-2-4-8(14)15/h5,14-15H,1-4,11H2,(H,12,13) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 3.40E+4 | n/a | n/a | n/a | n/a | n/a |
Drexel University
Curated by ChEMBL
| Assay Description Binding affinity to human arginase 1 using L-arginine as substrate by surface plasmon resonance assay |
J Med Chem 54: 5432-43 (2011)
Article DOI: 10.1021/jm200443b BindingDB Entry DOI: 10.7270/Q2TH8N21 |
More data for this Ligand-Target Pair | |
Arginase-1
(Homo sapiens (Human)) | BDBM50354832
(CHEMBL1834160)Show InChI InChI=1S/C7H13NO3/c8-6(7(10)11)4-2-1-3-5-9/h5-6H,1-4,8H2,(H,10,11)/t6-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 6.00E+4 | n/a | n/a | n/a | n/a | n/a |
Drexel University
Curated by ChEMBL
| Assay Description Displacement of [14C-guanidino]-L-arginine from human recombinant full length arginase 1 expressed in Escherichia coli BL21(DE3) by fixed point assay |
Bioorg Med Chem Lett 21: 5854-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.100 BindingDB Entry DOI: 10.7270/Q2KS6RZR |
More data for this Ligand-Target Pair | |
Arginase-1
(Homo sapiens (Human)) | BDBM50608140
(CHEMBL1230498) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PDB UniChem
| PDB
| n/a | n/a | n/a | 6.00E+4 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | 3D Structure (crystal) |