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Compile Data Set for Download or QSAR

Found 71 hits of ic50 for UniProtKB: P21860   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50210162
PNG
(CHEMBL3883534)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=C
Show InChI InChI=1S/C18H14ClFN4O2/c1-3-17(25)24-15-7-11-14(8-16(15)26-2)21-9-22-18(11)23-10-4-5-13(20)12(19)6-10/h3-9H,1H2,2H3,(H,24,25)(H,21,22,23)
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n/an/a 1n/an/an/an/an/an/a



Wuxi AppTec

Curated by ChEMBL


Assay Description
Inhibition of EGFR L858R mutant phosphorylation in human H3255 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISA

J Med Chem 60: 3002-3019 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01894
BindingDB Entry DOI: 10.7270/Q25X2CJZ
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50461172
PNG
(CHEMBL4228518)
Show SMILES CN(C)CCOc1ccc(Nc2ncc3nc(Sc4ccc(F)cc4)n(C4CCOCC4)c3n2)cc1
Show InChI InChI=1S/C26H29FN6O2S/c1-32(2)13-16-35-21-7-5-19(6-8-21)29-25-28-17-23-24(31-25)33(20-11-14-34-15-12-20)26(30-23)36-22-9-3-18(27)4-10-22/h3-10,17,20H,11-16H2,1-2H3,(H,28,29,31)
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Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of EGFR L858R mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assay

Bioorg Med Chem 26: 2173-2185 (2018)


Article DOI: 10.1016/j.bmc.2018.03.025
BindingDB Entry DOI: 10.7270/Q2H41V28
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50461178
PNG
(CHEMBL4225777)
Show SMILES CN(C)CCOc1ccc(Nc2ncc3nc(Sc4ccccc4)n(C4CCOCC4)c3n2)cc1
Show InChI InChI=1S/C26H30N6O2S/c1-31(2)14-17-34-21-10-8-19(9-11-21)28-25-27-18-23-24(30-25)32(20-12-15-33-16-13-20)26(29-23)35-22-6-4-3-5-7-22/h3-11,18,20H,12-17H2,1-2H3,(H,27,28,30)
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Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of EGFR L858R mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assay

Bioorg Med Chem 26: 2173-2185 (2018)


Article DOI: 10.1016/j.bmc.2018.03.025
BindingDB Entry DOI: 10.7270/Q2H41V28
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50461174
PNG
(CHEMBL4226676)
Show SMILES CN(C)C1CCN(CC1)c1ccc(Nc2ncc3nc(Sc4ccccc4)n(C4CCOCC4)c3n2)cc1
Show InChI InChI=1S/C29H35N7OS/c1-34(2)22-12-16-35(17-13-22)23-10-8-21(9-11-23)31-28-30-20-26-27(33-28)36(24-14-18-37-19-15-24)29(32-26)38-25-6-4-3-5-7-25/h3-11,20,22,24H,12-19H2,1-2H3,(H,30,31,33)
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Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of EGFR L858R mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assay

Bioorg Med Chem 26: 2173-2185 (2018)


Article DOI: 10.1016/j.bmc.2018.03.025
BindingDB Entry DOI: 10.7270/Q2H41V28
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50112173
PNG
(CHEMBL3608429)
Show SMILES CC(C)n1cnc2c(Nc3cnn(C)c3)nc(nc12)N1C[C@@H](F)[C@@H](C1)NC(=O)C=C |r|
Show InChI InChI=1S/C19H24FN9O/c1-5-15(30)24-14-9-28(8-13(14)20)19-25-17(23-12-6-22-27(4)7-12)16-18(26-19)29(10-21-16)11(2)3/h5-7,10-11,13-14H,1,8-9H2,2-4H3,(H,24,30)(H,23,25,26)/t13-,14-/m1/s1
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Wuxi AppTec

Curated by ChEMBL


Assay Description
Inhibition of EGFR L858R mutant phosphorylation in human H3255 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISA

J Med Chem 60: 3002-3019 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01894
BindingDB Entry DOI: 10.7270/Q25X2CJZ
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50450868
PNG
(CHEMBL4216679)
Show SMILES COc1nn(C)cc1Nc1nc(nc2n(cnc12)C(C)C)N1C[C@@H](F)[C@@H](C1)NC(=O)C=C |r|
Show InChI InChI=1S/C20H26FN9O2/c1-6-15(31)23-13-9-29(7-12(13)21)20-25-17(24-14-8-28(4)27-19(14)32-5)16-18(26-20)30(10-22-16)11(2)3/h6,8,10-13H,1,7,9H2,2-5H3,(H,23,31)(H,24,25,26)/t12-,13-/m1/s1
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Wuxi AppTec

Curated by ChEMBL


Assay Description
Inhibition of EGFR L858R mutant phosphorylation in human H3255 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISA

J Med Chem 60: 3002-3019 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01894
BindingDB Entry DOI: 10.7270/Q25X2CJZ
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50461179
PNG
(CHEMBL4226151)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3nc(Sc4ccccc4)n(C4CCOCC4)c3n2)cc1
Show InChI InChI=1S/C27H31N7OS/c1-32-13-15-33(16-14-32)21-9-7-20(8-10-21)29-26-28-19-24-25(31-26)34(22-11-17-35-18-12-22)27(30-24)36-23-5-3-2-4-6-23/h2-10,19,22H,11-18H2,1H3,(H,28,29,31)
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Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of EGFR L858R mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assay

Bioorg Med Chem 26: 2173-2185 (2018)


Article DOI: 10.1016/j.bmc.2018.03.025
BindingDB Entry DOI: 10.7270/Q2H41V28
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50029668
PNG
(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C28H33N7O2/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24/h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32)
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n/an/a 2.10n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of EGFR L858R mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assay

Bioorg Med Chem 26: 2173-2185 (2018)


Article DOI: 10.1016/j.bmc.2018.03.025
BindingDB Entry DOI: 10.7270/Q2H41V28
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50461175
PNG
(CHEMBL4225565)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3nc(Sc4ccccc4)n([C@H]4CC[C@H](O)CC4)c3n2)cc1 |r,wU:26.27,wD:29.31,(49.16,-41.25,;49.17,-39.71,;47.83,-38.93,;47.84,-37.4,;49.17,-36.63,;50.51,-37.39,;50.5,-38.94,;49.17,-35.09,;47.84,-34.31,;47.84,-32.77,;49.17,-32.01,;49.17,-30.47,;50.51,-29.7,;50.51,-28.16,;51.84,-27.39,;53.17,-28.15,;54.65,-27.67,;55.56,-28.92,;57.1,-28.92,;57.87,-27.59,;59.41,-27.6,;60.18,-26.26,;59.41,-24.93,;57.86,-24.93,;57.1,-26.27,;54.65,-30.18,;55.13,-31.64,;56.63,-31.96,;57.1,-33.43,;56.07,-34.57,;56.54,-36.04,;54.56,-34.24,;54.09,-32.78,;53.17,-29.7,;51.84,-30.47,;50.5,-32.77,;50.51,-34.31,)|
Show InChI InChI=1S/C28H33N7OS/c1-33-15-17-34(18-16-33)21-9-7-20(8-10-21)30-27-29-19-25-26(32-27)35(22-11-13-23(36)14-12-22)28(31-25)37-24-5-3-2-4-6-24/h2-10,19,22-23,36H,11-18H2,1H3,(H,29,30,32)/t22-,23-
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Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of EGFR L858R mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assay

Bioorg Med Chem 26: 2173-2185 (2018)


Article DOI: 10.1016/j.bmc.2018.03.025
BindingDB Entry DOI: 10.7270/Q2H41V28
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50461176
PNG
(CHEMBL4227084)
Show SMILES CN(C)CCOc1ccc(Nc2ncc3nc([S+]([O-])c4ccccc4)n(C4CCOCC4)c3n2)cc1
Show InChI InChI=1S/C26H30N6O3S/c1-31(2)14-17-35-21-10-8-19(9-11-21)28-25-27-18-23-24(30-25)32(20-12-15-34-16-13-20)26(29-23)36(33)22-6-4-3-5-7-22/h3-11,18,20H,12-17H2,1-2H3,(H,27,28,30)
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Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of EGFR L858R mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assay

Bioorg Med Chem 26: 2173-2185 (2018)


Article DOI: 10.1016/j.bmc.2018.03.025
BindingDB Entry DOI: 10.7270/Q2H41V28
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50450870
PNG
(Mavelertinib | PF-06747775)
Show SMILES COc1nn(C)cc1Nc1nc(nc2n(C)cnc12)N1C[C@@H](F)[C@@H](C1)NC(=O)C=C |r|
Show InChI InChI=1S/C18H22FN9O2/c1-5-13(29)21-11-8-28(6-10(11)19)18-23-15(14-16(24-18)26(2)9-20-14)22-12-7-27(3)25-17(12)30-4/h5,7,9-11H,1,6,8H2,2-4H3,(H,21,29)(H,22,23,24)/t10-,11-/m1/s1
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Wuxi AppTec

Curated by ChEMBL


Assay Description
Inhibition of EGFR L858R mutant phosphorylation in human H3255 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISA

J Med Chem 60: 3002-3019 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01894
BindingDB Entry DOI: 10.7270/Q25X2CJZ
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50437353
PNG
(CHEMBL2408045)
Show SMILES CNC(=O)CN1CCC(CC1)Oc1cc2c(Nc3cccc(Cl)c3F)ncnc2cc1OC
Show InChI InChI=1S/C23H25ClFN5O3/c1-26-21(31)12-30-8-6-14(7-9-30)33-20-10-15-18(11-19(20)32-2)27-13-28-23(15)29-17-5-3-4-16(24)22(17)25/h3-5,10-11,13-14H,6-9,12H2,1-2H3,(H,26,31)(H,27,28,29)
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Arromax Pharmatech Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human HER3 expressed in baculovirus/Sf21 system by ELISA

Eur J Med Chem 170: 55-72 (2019)


Article DOI: 10.1016/j.ejmech.2019.03.004
BindingDB Entry DOI: 10.7270/Q2474F5D
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50461180
PNG
(CHEMBL4225306)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3nc(Sc4ccccc4)n(C4CCCC4)c3n2)cc1
Show InChI InChI=1S/C27H31N7S/c1-32-15-17-33(18-16-32)21-13-11-20(12-14-21)29-26-28-19-24-25(31-26)34(22-7-5-6-8-22)27(30-24)35-23-9-3-2-4-10-23/h2-4,9-14,19,22H,5-8,15-18H2,1H3,(H,28,29,31)
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Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of EGFR L858R mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assay

Bioorg Med Chem 26: 2173-2185 (2018)


Article DOI: 10.1016/j.bmc.2018.03.025
BindingDB Entry DOI: 10.7270/Q2H41V28
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50461177
PNG
(CHEMBL4225951)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3nc([S+]([O-])c4ccccc4)n(C4CCCC4)c3n2)cc1
Show InChI InChI=1S/C27H31N7OS/c1-32-15-17-33(18-16-32)21-13-11-20(12-14-21)29-26-28-19-24-25(31-26)34(22-7-5-6-8-22)27(30-24)36(35)23-9-3-2-4-10-23/h2-4,9-14,19,22H,5-8,15-18H2,1H3,(H,28,29,31)
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Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of EGFR L858R mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assay

Bioorg Med Chem 26: 2173-2185 (2018)


Article DOI: 10.1016/j.bmc.2018.03.025
BindingDB Entry DOI: 10.7270/Q2H41V28
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50461173
PNG
(CHEMBL4226937)
Show SMILES CN(C)CCOc1ccc(Nc2ncc3nc(Sc4cccc(F)c4)n(C4CCOCC4)c3n2)cc1
Show InChI InChI=1S/C26H29FN6O2S/c1-32(2)12-15-35-21-8-6-19(7-9-21)29-25-28-17-23-24(31-25)33(20-10-13-34-14-11-20)26(30-23)36-22-5-3-4-18(27)16-22/h3-9,16-17,20H,10-15H2,1-2H3,(H,28,29,31)
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Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of EGFR L858R mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assay

Bioorg Med Chem 26: 2173-2185 (2018)


Article DOI: 10.1016/j.bmc.2018.03.025
BindingDB Entry DOI: 10.7270/Q2H41V28
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50112176
PNG
(CHEMBL3608432)
Show SMILES CC(C)n1cnc2c(Nc3cn(C)nc3C)nc(nc12)N1C[C@@H](F)[C@@H](C1)NC(=O)C=C |r|
Show InChI InChI=1S/C20H26FN9O/c1-6-16(31)23-15-9-29(7-13(15)21)20-25-18(24-14-8-28(5)27-12(14)4)17-19(26-20)30(10-22-17)11(2)3/h6,8,10-11,13,15H,1,7,9H2,2-5H3,(H,23,31)(H,24,25,26)/t13-,15-/m1/s1
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Wuxi AppTec

Curated by ChEMBL


Assay Description
Inhibition of EGFR L858R mutant phosphorylation in human H3255 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISA

J Med Chem 60: 3002-3019 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01894
BindingDB Entry DOI: 10.7270/Q25X2CJZ
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM5446
PNG
(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Show SMILES COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC
Show InChI InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25)
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n/an/a 10n/an/an/an/an/an/a



Wuxi AppTec

Curated by ChEMBL


Assay Description
Inhibition of EGFR L858R mutant phosphorylation in human H3255 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISA

J Med Chem 60: 3002-3019 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01894
BindingDB Entry DOI: 10.7270/Q25X2CJZ
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50467144
PNG
(CHEMBL4288300)
Show SMILES COc1cccc(Nc2cc(Nc3cc(OC)ccc3OC)ncn2)c1
Show InChI InChI=1S/C19H20N4O3/c1-24-14-6-4-5-13(9-14)22-18-11-19(21-12-20-18)23-16-10-15(25-2)7-8-17(16)26-3/h4-12H,1-3H3,(H2,20,21,22,23)
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Wenzhou Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...

Eur J Med Chem 157: 1300-1325 (2018)


Article DOI: 10.1016/j.ejmech.2018.08.031
BindingDB Entry DOI: 10.7270/Q2SF2ZVS
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50467162
PNG
(CHEMBL4282460)
Show SMILES OC(=O)CCCC(=O)Nc1cc(Nc2cccc(Cl)c2)ncn1
Show InChI InChI=1S/C15H15ClN4O3/c16-10-3-1-4-11(7-10)19-12-8-13(18-9-17-12)20-14(21)5-2-6-15(22)23/h1,3-4,7-9H,2,5-6H2,(H,22,23)(H2,17,18,19,20,21)
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Wenzhou Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...

Eur J Med Chem 157: 1300-1325 (2018)


Article DOI: 10.1016/j.ejmech.2018.08.031
BindingDB Entry DOI: 10.7270/Q2SF2ZVS
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50159360
PNG
(CHEMBL3786098)
Show SMILES CO[C@H]1CN(C[C@@H]1COc1nc(Nc2cnn(C)c2)nc2[nH]cc(Cl)c12)C(=O)C=C |r|
Show InChI InChI=1S/C19H22ClN7O3/c1-4-15(28)27-7-11(14(9-27)29-3)10-30-18-16-13(20)6-21-17(16)24-19(25-18)23-12-5-22-26(2)8-12/h4-6,8,11,14H,1,7,9-10H2,2-3H3,(H2,21,23,24,25)/t11-,14+/m1/s1
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Wuxi AppTec

Curated by ChEMBL


Assay Description
Inhibition of EGFR L858R mutant phosphorylation in human H3255 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISA

J Med Chem 60: 3002-3019 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01894
BindingDB Entry DOI: 10.7270/Q25X2CJZ
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50611358
PNG
(CHEMBL5285282)		PDB
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50467143
PNG
(CHEMBL4283970)
Show SMILES OC(=O)CCCC(=O)Nc1cc(ncn1)N1CCOCC1
Show InChI InChI=1S/C13H18N4O4/c18-12(2-1-3-13(19)20)16-10-8-11(15-9-14-10)17-4-6-21-7-5-17/h8-9H,1-7H2,(H,19,20)(H,14,15,16,18)
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Wenzhou Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...

Eur J Med Chem 157: 1300-1325 (2018)


Article DOI: 10.1016/j.ejmech.2018.08.031
BindingDB Entry DOI: 10.7270/Q2SF2ZVS
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50467148
PNG
(CHEMBL4294156)
Show SMILES COc1cccc(Nc2cc(NC(=O)CCCC(O)=O)ncn2)c1
Show InChI InChI=1S/C16H18N4O4/c1-24-12-5-2-4-11(8-12)19-13-9-14(18-10-17-13)20-15(21)6-3-7-16(22)23/h2,4-5,8-10H,3,6-7H2,1H3,(H,22,23)(H2,17,18,19,20,21)
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Wenzhou Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...

Eur J Med Chem 157: 1300-1325 (2018)


Article DOI: 10.1016/j.ejmech.2018.08.031
BindingDB Entry DOI: 10.7270/Q2SF2ZVS
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50450867
PNG
(CHEMBL4206501)
Show SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ccnc(n1)-c1cn(C)c2ccccc12
Show InChI InChI=1S/C28H33N7O2/c1-7-27(36)31-21-16-22(25(37-6)17-24(21)34(4)15-14-33(2)3)30-26-12-13-29-28(32-26)20-18-35(5)23-11-9-8-10-19(20)23/h7-13,16-18H,1,14-15H2,2-6H3,(H,31,36)(H,29,30,32)
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Wuxi AppTec

Curated by ChEMBL


Assay Description
Inhibition of EGFR L858R mutant phosphorylation in human H3255 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISA

J Med Chem 60: 3002-3019 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01894
BindingDB Entry DOI: 10.7270/Q25X2CJZ
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM149404
PNG
(AVL-301 | CHEMBL3545308 | CNX-419 | CO-1686 | Roci...)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(C)=O
Show InChI InChI=1S/C27H28F3N7O3/c1-4-24(39)32-18-6-5-7-19(14-18)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-20(15-23(22)40-3)37-12-10-36(11-13-37)17(2)38/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,39)(H2,31,33,34,35)
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n/an/a 46n/an/an/an/an/an/a



Wuxi AppTec

Curated by ChEMBL


Assay Description
Inhibition of EGFR L858R mutant phosphorylation in human H3255 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISA

J Med Chem 60: 3002-3019 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01894
BindingDB Entry DOI: 10.7270/Q25X2CJZ
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50611359
PNG
(CHEMBL5282275)		PDB
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50467152
PNG
(CHEMBL4283823)
Show SMILES COc1ccc(Nc2cc(NC(=O)c3ccccc3)ncn2)cc1
Show InChI InChI=1S/C18H16N4O2/c1-24-15-9-7-14(8-10-15)21-16-11-17(20-12-19-16)22-18(23)13-5-3-2-4-6-13/h2-12H,1H3,(H2,19,20,21,22,23)
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Wenzhou Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...

Eur J Med Chem 157: 1300-1325 (2018)


Article DOI: 10.1016/j.ejmech.2018.08.031
BindingDB Entry DOI: 10.7270/Q2SF2ZVS
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50467163
PNG
(CHEMBL4290750)
Show SMILES CCOC(=O)c1ccc(Nc2cc(NC(=O)CCCC(O)=O)ncn2)cc1
Show InChI InChI=1S/C18H20N4O5/c1-2-27-18(26)12-6-8-13(9-7-12)21-14-10-15(20-11-19-14)22-16(23)4-3-5-17(24)25/h6-11H,2-5H2,1H3,(H,24,25)(H2,19,20,21,22,23)
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Wenzhou Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...

Eur J Med Chem 157: 1300-1325 (2018)


Article DOI: 10.1016/j.ejmech.2018.08.031
BindingDB Entry DOI: 10.7270/Q2SF2ZVS
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50467146
PNG
(CHEMBL1379917)
Show SMILES Fc1ccc(cc1)C(=O)Nc1cc(ncn1)N1CCOCC1
Show InChI InChI=1S/C15H15FN4O2/c16-12-3-1-11(2-4-12)15(21)19-13-9-14(18-10-17-13)20-5-7-22-8-6-20/h1-4,9-10H,5-8H2,(H,17,18,19,21)
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Wenzhou Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...

Eur J Med Chem 157: 1300-1325 (2018)


Article DOI: 10.1016/j.ejmech.2018.08.031
BindingDB Entry DOI: 10.7270/Q2SF2ZVS
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50467147
PNG
(CHEMBL4283097)
Show SMILES COc1ccc(OC)c(Nc2cc(NCCc3cccs3)ncn2)c1
Show InChI InChI=1S/C18H20N4O2S/c1-23-13-5-6-16(24-2)15(10-13)22-18-11-17(20-12-21-18)19-8-7-14-4-3-9-25-14/h3-6,9-12H,7-8H2,1-2H3,(H2,19,20,21,22)
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Wenzhou Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...

Eur J Med Chem 157: 1300-1325 (2018)


Article DOI: 10.1016/j.ejmech.2018.08.031
BindingDB Entry DOI: 10.7270/Q2SF2ZVS
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50467151
PNG
(CHEMBL4293690)
Show SMILES COc1ccc(OC)c(Nc2cc(Nc3ccc(cc3)N3CCN(C)CC3)ncn2)c1
Show InChI InChI=1S/C23H28N6O2/c1-28-10-12-29(13-11-28)18-6-4-17(5-7-18)26-22-15-23(25-16-24-22)27-20-14-19(30-2)8-9-21(20)31-3/h4-9,14-16H,10-13H2,1-3H3,(H2,24,25,26,27)
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Wenzhou Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...

Eur J Med Chem 157: 1300-1325 (2018)


Article DOI: 10.1016/j.ejmech.2018.08.031
BindingDB Entry DOI: 10.7270/Q2SF2ZVS
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50467161
PNG
(CHEMBL4278997)
Show SMILES OC(=O)CCCC(=O)Nc1cc(Nc2ccccc2)ncn1
Show InChI InChI=1S/C15H16N4O3/c20-14(7-4-8-15(21)22)19-13-9-12(16-10-17-13)18-11-5-2-1-3-6-11/h1-3,5-6,9-10H,4,7-8H2,(H,21,22)(H2,16,17,18,19,20)
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Wenzhou Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...

Eur J Med Chem 157: 1300-1325 (2018)


Article DOI: 10.1016/j.ejmech.2018.08.031
BindingDB Entry DOI: 10.7270/Q2SF2ZVS
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50467158
PNG
(CHEMBL4280395)
Show SMILES COc1ccc(OC)c(Nc2cc(Nc3ccc(F)cc3)ncn2)c1
Show InChI InChI=1S/C18H17FN4O2/c1-24-14-7-8-16(25-2)15(9-14)23-18-10-17(20-11-21-18)22-13-5-3-12(19)4-6-13/h3-11H,1-2H3,(H2,20,21,22,23)
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Wenzhou Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...

Eur J Med Chem 157: 1300-1325 (2018)


Article DOI: 10.1016/j.ejmech.2018.08.031
BindingDB Entry DOI: 10.7270/Q2SF2ZVS
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50467159
PNG
(CHEMBL4288262)
Show SMILES Clc1ccc(Nc2cc(Nc3cccc(Cl)n3)ncn2)cc1
Show InChI InChI=1S/C15H11Cl2N5/c16-10-4-6-11(7-5-10)20-14-8-15(19-9-18-14)22-13-3-1-2-12(17)21-13/h1-9H,(H2,18,19,20,21,22)
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Wenzhou Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...

Eur J Med Chem 157: 1300-1325 (2018)


Article DOI: 10.1016/j.ejmech.2018.08.031
BindingDB Entry DOI: 10.7270/Q2SF2ZVS
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50467155
PNG
(CHEMBL4276965)
Show SMILES COc1ccc(OC)c(Nc2cc(Nc3ccc(cc3)S(N)(=O)=O)ncn2)c1
Show InChI InChI=1S/C18H19N5O4S/c1-26-13-5-8-16(27-2)15(9-13)23-18-10-17(20-11-21-18)22-12-3-6-14(7-4-12)28(19,24)25/h3-11H,1-2H3,(H2,19,24,25)(H2,20,21,22,23)
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Wenzhou Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...

Eur J Med Chem 157: 1300-1325 (2018)


Article DOI: 10.1016/j.ejmech.2018.08.031
BindingDB Entry DOI: 10.7270/Q2SF2ZVS
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50467149
PNG
(CHEMBL4287629)
Show SMILES OC(=O)CCC(=O)Nc1cc(Nc2ccc(Cl)cc2)ncn1
Show InChI InChI=1S/C14H13ClN4O3/c15-9-1-3-10(4-2-9)18-11-7-12(17-8-16-11)19-13(20)5-6-14(21)22/h1-4,7-8H,5-6H2,(H,21,22)(H2,16,17,18,19,20)
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Wenzhou Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...

Eur J Med Chem 157: 1300-1325 (2018)


Article DOI: 10.1016/j.ejmech.2018.08.031
BindingDB Entry DOI: 10.7270/Q2SF2ZVS
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50467142
PNG
(CHEMBL4293134)
Show SMILES CCOc1ccc(Nc2cc(NC(=O)c3ccccc3)ncn2)cc1
Show InChI InChI=1S/C19H18N4O2/c1-2-25-16-10-8-15(9-11-16)22-17-12-18(21-13-20-17)23-19(24)14-6-4-3-5-7-14/h3-13H,2H2,1H3,(H2,20,21,22,23,24)
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n/an/a 1.21E+3n/an/an/an/an/an/a



Wenzhou Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...

Eur J Med Chem 157: 1300-1325 (2018)


Article DOI: 10.1016/j.ejmech.2018.08.031
BindingDB Entry DOI: 10.7270/Q2SF2ZVS
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50467153
PNG
(CHEMBL4289682)
Show SMILES OC(=O)CCCC(=O)Nc1cc(Nc2ccc(Cl)cc2)ncn1
Show InChI InChI=1S/C15H15ClN4O3/c16-10-4-6-11(7-5-10)19-12-8-13(18-9-17-12)20-14(21)2-1-3-15(22)23/h4-9H,1-3H2,(H,22,23)(H2,17,18,19,20,21)
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n/an/a 1.32E+3n/an/an/an/an/an/a



Wenzhou Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...

Eur J Med Chem 157: 1300-1325 (2018)


Article DOI: 10.1016/j.ejmech.2018.08.031
BindingDB Entry DOI: 10.7270/Q2SF2ZVS
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50467164
PNG
(CHEMBL4288761)
Show SMILES CCOC(=O)CCC(=O)Nc1cc(Nc2cccc(Br)c2)ncn1
Show InChI InChI=1S/C16H17BrN4O3/c1-2-24-16(23)7-6-15(22)21-14-9-13(18-10-19-14)20-12-5-3-4-11(17)8-12/h3-5,8-10H,2,6-7H2,1H3,(H2,18,19,20,21,22)
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n/an/a 1.35E+3n/an/an/an/an/an/a



Wenzhou Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...

Eur J Med Chem 157: 1300-1325 (2018)


Article DOI: 10.1016/j.ejmech.2018.08.031
BindingDB Entry DOI: 10.7270/Q2SF2ZVS
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50467166
PNG
(CHEMBL4278031)
Show SMILES COc1cccc(Nc2cc(Nc3cccc(Cl)c3)ncn2)c1
Show InChI InChI=1S/C17H15ClN4O/c1-23-15-7-3-6-14(9-15)22-17-10-16(19-11-20-17)21-13-5-2-4-12(18)8-13/h2-11H,1H3,(H2,19,20,21,22)
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n/an/a 1.57E+3n/an/an/an/an/an/a



Wenzhou Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...

Eur J Med Chem 157: 1300-1325 (2018)


Article DOI: 10.1016/j.ejmech.2018.08.031
BindingDB Entry DOI: 10.7270/Q2SF2ZVS
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50467160
PNG
(CHEMBL4281413)
Show SMILES Fc1ccc(cc1)C(=O)Nc1cc(Nc2ccc(Cl)cc2)ncn1
Show InChI InChI=1S/C17H12ClFN4O/c18-12-3-7-14(8-4-12)22-15-9-16(21-10-20-15)23-17(24)11-1-5-13(19)6-2-11/h1-10H,(H2,20,21,22,23,24)
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n/an/a 1.61E+3n/an/an/an/an/an/a



Wenzhou Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...

Eur J Med Chem 157: 1300-1325 (2018)


Article DOI: 10.1016/j.ejmech.2018.08.031
BindingDB Entry DOI: 10.7270/Q2SF2ZVS
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50467157
PNG
(CHEMBL4292110)
Show SMILES CCOC(=O)c1ccc(Nc2cc(Nc3cccc(OC)c3)ncn2)cc1
Show InChI InChI=1S/C20H20N4O3/c1-3-27-20(25)14-7-9-15(10-8-14)23-18-12-19(22-13-21-18)24-16-5-4-6-17(11-16)26-2/h4-13H,3H2,1-2H3,(H2,21,22,23,24)
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n/an/a 1.75E+3n/an/an/an/an/an/a



Wenzhou Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...

Eur J Med Chem 157: 1300-1325 (2018)


Article DOI: 10.1016/j.ejmech.2018.08.031
BindingDB Entry DOI: 10.7270/Q2SF2ZVS
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50467150
PNG
(CHEMBL4284911)
Show SMILES COc1cccc(Nc2cc(Nc3ccc(cc3)S(N)(=O)=O)ncn2)c1
Show InChI InChI=1S/C17H17N5O3S/c1-25-14-4-2-3-13(9-14)22-17-10-16(19-11-20-17)21-12-5-7-15(8-6-12)26(18,23)24/h2-11H,1H3,(H2,18,23,24)(H2,19,20,21,22)
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n/an/a 1.85E+3n/an/an/an/an/an/a



Wenzhou Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...

Eur J Med Chem 157: 1300-1325 (2018)


Article DOI: 10.1016/j.ejmech.2018.08.031
BindingDB Entry DOI: 10.7270/Q2SF2ZVS
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM494927
PNG
((2S,4R)-1-((S)-2-(6-(4-(4-((4-((3-chloro-4-fluorop...)
Show SMILES CN(C)C\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OCCCCOCCCCOCCCCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)C(C)(C)C |r|
Show InChI InChI=1S/C56H73ClFN9O8S/c1-37-51(76-36-62-37)39-19-17-38(18-20-39)33-59-54(71)47-30-41(68)34-67(47)55(72)52(56(2,3)4)65-50(70)15-8-7-9-24-73-25-10-11-26-74-27-12-13-28-75-48-32-45-42(31-46(48)64-49(69)16-14-23-66(5)6)53(61-35-60-45)63-40-21-22-44(58)43(57)29-40/h14,16-22,29,31-32,35-36,41,47,52,68H,7-13,15,23-28,30,33-34H2,1-6H3,(H,59,71)(H,64,69)(H,65,70)(H,60,61,63)/b16-14+/t41-,47+,52-/m1/s1
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US Patent
n/an/a 6.60E+3n/an/an/an/an/an/a



ARVINAS OPERATIONS, INC.; YALE UNIVERSITY

US Patent


Assay Description
All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...

US Patent US10994015 (2021)


BindingDB Entry DOI: 10.7270/Q2NS0Z1G
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM494934
PNG
(2-(2,6-dioxopiperidin-3-yl)-5-(2-(4-(2-((1-isoprop...)
Show SMILES COC1CCN(CC1)c1nccc(Nc2cc3n(C(C)C)c(COCCN4CCN(CCOc5ccc6C(=O)N(C7CCC(=O)NC7=O)C(=O)c6c5)CC4)nc3cn2)n1
Show InChI InChI=1S/C41H51N11O7/c1-26(2)51-33-23-35(45-34-8-11-42-41(46-34)50-12-9-27(57-3)10-13-50)43-24-31(33)44-36(51)25-58-20-18-48-14-16-49(17-15-48)19-21-59-28-4-5-29-30(22-28)40(56)52(39(29)55)32-6-7-37(53)47-38(32)54/h4-5,8,11,22-24,26-27,32H,6-7,9-10,12-21,25H2,1-3H3,(H,47,53,54)(H,42,43,45,46)
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n/an/a 8.60E+3n/an/an/an/an/an/a



ARVINAS OPERATIONS, INC.; YALE UNIVERSITY

US Patent


Assay Description
All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...

US Patent US10994015 (2021)


BindingDB Entry DOI: 10.7270/Q2NS0Z1G
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50467141
PNG
(CHEMBL4283517)
Show SMILES COc1cc(Nc2cc(Nc3ccc(Cl)cc3)ncn2)cc(OC)c1OC
Show InChI InChI=1S/C19H19ClN4O3/c1-25-15-8-14(9-16(26-2)19(15)27-3)24-18-10-17(21-11-22-18)23-13-6-4-12(20)5-7-13/h4-11H,1-3H3,(H2,21,22,23,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Wenzhou Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...

Eur J Med Chem 157: 1300-1325 (2018)


Article DOI: 10.1016/j.ejmech.2018.08.031
BindingDB Entry DOI: 10.7270/Q2SF2ZVS
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50467145
PNG
(CHEMBL4282879)
Show SMILES COc1ccc(OC)c(Nc2cc(NC(=O)CCCC(O)=O)ncn2)c1
Show InChI InChI=1S/C17H20N4O5/c1-25-11-6-7-13(26-2)12(8-11)20-14-9-15(19-10-18-14)21-16(22)4-3-5-17(23)24/h6-10H,3-5H2,1-2H3,(H,23,24)(H2,18,19,20,21,22)
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Wenzhou Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...

Eur J Med Chem 157: 1300-1325 (2018)


Article DOI: 10.1016/j.ejmech.2018.08.031
BindingDB Entry DOI: 10.7270/Q2SF2ZVS
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50467154
PNG
(CHEMBL4286263)
Show SMILES OC(=O)CCCC(=O)Nc1cc(Nc2cccc(Br)c2)ncn1
Show InChI InChI=1S/C15H15BrN4O3/c16-10-3-1-4-11(7-10)19-12-8-13(18-9-17-12)20-14(21)5-2-6-15(22)23/h1,3-4,7-9H,2,5-6H2,(H,22,23)(H2,17,18,19,20,21)
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Wenzhou Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...

Eur J Med Chem 157: 1300-1325 (2018)


Article DOI: 10.1016/j.ejmech.2018.08.031
BindingDB Entry DOI: 10.7270/Q2SF2ZVS
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50467156
PNG
(CHEMBL4286871)
Show SMILES CCNc1cc(Nc2cccc(Cl)c2)ncn1
Show InChI InChI=1S/C12H13ClN4/c1-2-14-11-7-12(16-8-15-11)17-10-5-3-4-9(13)6-10/h3-8H,2H2,1H3,(H2,14,15,16,17)
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Wenzhou Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...

Eur J Med Chem 157: 1300-1325 (2018)


Article DOI: 10.1016/j.ejmech.2018.08.031
BindingDB Entry DOI: 10.7270/Q2SF2ZVS
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-3


(Homo sapiens (Human))		BDBM50467165
PNG
(CHEMBL4283061)
Show SMILES CCOC(=O)CCCC(=O)Nc1cc(Nc2cccc(Cl)c2)ncn1
Show InChI InChI=1S/C17H19ClN4O3/c1-2-25-17(24)8-4-7-16(23)22-15-10-14(19-11-20-15)21-13-6-3-5-12(18)9-13/h3,5-6,9-11H,2,4,7-8H2,1H3,(H2,19,20,21,22,23)
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Wenzhou Medical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...

Eur J Med Chem 157: 1300-1325 (2018)


Article DOI: 10.1016/j.ejmech.2018.08.031
BindingDB Entry DOI: 10.7270/Q2SF2ZVS
More data for this
Ligand-Target Pair
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