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Compile Data Set for Download or QSAR

Found 104 hits of ic50 for UniProtKB: P09483   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50088456
PNG
(1-(6-Chloro-5-methoxy-pyridin-3-yl)-[1,4]diazepane...)
Show SMILES COc1cc(cnc1Cl)N1CCCNCC1
Show InChI InChI=1S/C11H16ClN3O/c1-16-10-7-9(8-14-11(10)12)15-5-2-3-13-4-6-15/h7-8,13H,2-6H2,1H3
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n/an/a 0.680n/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for Nicotinic acetylcholine receptor alpha4-beta2 (alpha4 beta-2 subtype of nAChRs) in rat cerebral cortical membrane using...


J Med Chem 43: 2217-26 (2000)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50088453
PNG
(1-(6-Bromo-5-ethoxy-pyridin-3-yl)-[1,4]diazepane |...)
Show SMILES CCOc1cc(cnc1Br)N1CCCNCC1
Show InChI InChI=1S/C12H18BrN3O/c1-2-17-11-8-10(9-15-12(11)13)16-6-3-4-14-5-7-16/h8-9,14H,2-7H2,1H3
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n/an/a 0.870n/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for Nicotinic acetylcholine receptor alpha4-beta2 (alpha4 beta-2 subtype of nAChRs) in rat cerebral cortical membrane using...


J Med Chem 43: 2217-26 (2000)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50088454
PNG
(1-(6-Bromo-pyridin-3-yl)-[1,4]diazepane | 1-(6-bro...)
Show SMILES Brc1ccc(cn1)N1CCCNCC1
Show InChI InChI=1S/C10H14BrN3/c11-10-3-2-9(8-13-10)14-6-1-4-12-5-7-14/h2-3,8,12H,1,4-7H2
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n/an/a 1n/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for Nicotinic acetylcholine receptor alpha4-beta2 (alpha4 beta-2 subtype of nAChRs) in rat cerebral cortical membrane using...


J Med Chem 43: 2217-26 (2000)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM82070
PNG
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Show SMILES CN1CCC[C@H]1c1cccnc1 |r|
Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1
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n/an/a 1.65n/an/an/an/an/an/a



Pfizer Global Research& Development

Curated by ChEMBL


Assay Description
Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration method


Bioorg Med Chem Lett 19: 4747-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.059
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50143313
PNG
((12S,13aS)-12-Methoxy-1,4,5,6,9,11,12,13-octahydro...)
Show SMILES CO[C@H]1CC=C2CCN3CCC4=C(CC(=O)OC4)[C@]23C1 |t:4,11|
Show InChI InChI=1S/C16H21NO3/c1-19-13-3-2-12-5-7-17-6-4-11-10-20-15(18)8-14(11)16(12,17)9-13/h2,13H,3-10H2,1H3/t13-,16-/m0/s1
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n/an/a 3.70n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Blockade of Nicotinic acetylcholine receptor alpha4-beta2


Bioorg Med Chem Lett 14: 1879-87 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.004
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50088450
PNG
(1-(5-(vinyloxy)pyridin-3-yl)-1,4-diazepane | 1-(5-...)
Show SMILES C=COc1cncc(c1)N1CCCNCC1
Show InChI InChI=1S/C12H17N3O/c1-2-16-12-8-11(9-14-10-12)15-6-3-4-13-5-7-15/h2,8-10,13H,1,3-7H2
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n/an/a 5n/an/an/an/an/an/a



NeuroSearch A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity for Nicotinic acetylcholine receptor alpha4-beta2 (alpha4 beta-2 subtype of nAChRs) in rat cerebral cortical membrane using...


J Med Chem 43: 2217-26 (2000)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50143302
PNG
((S)-1-dodecyl-3-(1-methylpyrrolidin-2-yl)pyridiniu...)
Show SMILES CCCCCCCCCCCC[n+]1cccc(c1)[C@@H]1CCCN1C
Show InChI InChI=1S/C22H39N2/c1-3-4-5-6-7-8-9-10-11-12-18-24-19-13-15-21(20-24)22-16-14-17-23(22)2/h13,15,19-20,22H,3-12,14,16-18H2,1-2H3/q+1/t22-/m0/s1
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n/an/a 9n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against nAChR mediated nicotine-evoked [3H]-DA overflow using rat striatal slices


Bioorg Med Chem Lett 14: 1869-74 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.074
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50088651
PNG
(4-[2-Chloro-5-((R)-pyrrolidin-3-yloxy)-pyridin-3-y...)
Show SMILES Clc1ncc(O[C@@H]2CCNC2)cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C16H14ClN3O/c17-16-15(12-3-1-11(8-18)2-4-12)7-14(10-20-16)21-13-5-6-19-9-13/h1-4,7,10,13,19H,5-6,9H2/t13-/m1/s1
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n/an/a 22n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2


Bioorg Med Chem Lett 10: 1063-6 (2000)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50143305
PNG
((3aR,9bS)-6-Decyl-1-methyl-2,3,3a,4,5,9b-hexahydro...)
Show SMILES CCCCCCCCCC[n+]1cccc2[C@@H]3[C@@H](CCN3C)CCc12
Show InChI InChI=1S/C22H37N2/c1-3-4-5-6-7-8-9-10-16-24-17-11-12-20-21(24)14-13-19-15-18-23(2)22(19)20/h11-12,17,19,22H,3-10,13-16,18H2,1-2H3/q+1/t19-,22+/m1/s1
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n/an/a 30n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against nAChR mediated nicotine-evoked [3H]-DA overflow using rat striatal slices


Bioorg Med Chem Lett 14: 1869-74 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.074
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50143300
PNG
((3aR,9bS)-1-Methyl-6-undecyl-2,3,3a,4,5,9b-hexahyd...)
Show SMILES CCCCCCCCCCC[n+]1cccc2[C@@H]3[C@@H](CCN3C)CCc12
Show InChI InChI=1S/C23H39N2/c1-3-4-5-6-7-8-9-10-11-17-25-18-12-13-21-22(25)15-14-20-16-19-24(2)23(20)21/h12-13,18,20,23H,3-11,14-17,19H2,1-2H3/q+1/t20-,23+/m1/s1
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n/an/a 40n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against nAChR mediated nicotine-evoked [3H]-DA overflow using rat striatal slices


Bioorg Med Chem Lett 14: 1869-74 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.074
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50143306
PNG
((3aR,9bS)-1-Methyl-6-octyl-2,3,3a,4,5,9b-hexahydro...)
Show SMILES CCCCCCCC[n+]1cccc2[C@@H]3[C@@H](CCN3C)CCc12
Show InChI InChI=1S/C20H33N2/c1-3-4-5-6-7-8-14-22-15-9-10-18-19(22)12-11-17-13-16-21(2)20(17)18/h9-10,15,17,20H,3-8,11-14,16H2,1-2H3/q+1/t17-,20+/m1/s1
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n/an/a 40n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against nAChR mediated nicotine-evoked [3H]-DA overflow using rat striatal slices


Bioorg Med Chem Lett 14: 1869-74 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.074
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50143303
PNG
((3aS,9bR)-1-Methyl-8-undecyl-2,3,3a,4,5,9b-hexahyd...)
Show SMILES CCCCCCCCCCC[n+]1ccc2CC[C@H]3CCN(C)[C@H]3c2c1
Show InChI InChI=1S/C23H39N2/c1-3-4-5-6-7-8-9-10-11-16-25-18-15-20-12-13-21-14-17-24(2)23(21)22(20)19-25/h15,18-19,21,23H,3-14,16-17H2,1-2H3/q+1/t21-,23+/m0/s1
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n/an/a 40n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of [3H]-nicotine binding to Nicotinic acetylcholine receptor alpha4-beta2 in rat brain


Bioorg Med Chem Lett 14: 1869-74 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.074
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50088636
PNG
(3-((R)-Pyrrolidin-3-yloxy)-pyridine | CHEMBL10260)
Show SMILES C1C[C@H](CN1)Oc1cccnc1
Show InChI InChI=1S/C9H12N2O/c1-2-8(6-10-4-1)12-9-3-5-11-7-9/h1-2,4,6,9,11H,3,5,7H2/t9-/m1/s1
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n/an/a 45n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2


Bioorg Med Chem Lett 10: 1063-6 (2000)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50088650
PNG
(2-Chloro-3-ethynyl-5-((R)-pyrrolidin-3-yloxy)-pyri...)
Show SMILES Clc1ncc(O[C@@H]2CCNC2)cc1C#C
Show InChI InChI=1S/C11H11ClN2O/c1-2-8-5-10(7-14-11(8)12)15-9-3-4-13-6-9/h1,5,7,9,13H,3-4,6H2/t9-/m1/s1
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n/an/a 46n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2


Bioorg Med Chem Lett 10: 1063-6 (2000)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50088630
PNG
(2-Chloro-3-(3-methoxy-phenyl)-5-((R)-pyrrolidin-3-...)
Show SMILES COc1cccc(c1)-c1cc(O[C@@H]2CCNC2)cnc1Cl
Show InChI InChI=1S/C16H17ClN2O2/c1-20-12-4-2-3-11(7-12)15-8-14(10-19-16(15)17)21-13-5-6-18-9-13/h2-4,7-8,10,13,18H,5-6,9H2,1H3/t13-/m1/s1
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n/an/a 58n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2


Bioorg Med Chem Lett 10: 1063-6 (2000)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50088637
PNG
(3-Ethynyl-5-((R)-pyrrolidin-3-yloxy)-pyridine | CH...)
Show SMILES C#Cc1cncc(O[C@@H]2CCNC2)c1
Show InChI InChI=1S/C11H12N2O/c1-2-9-5-11(8-13-6-9)14-10-3-4-12-7-10/h1,5-6,8,10,12H,3-4,7H2/t10-/m1/s1
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n/an/a 62n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2


Bioorg Med Chem Lett 10: 1063-6 (2000)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50088639
PNG
(2-Chloro-3-methyl-5-((R)-pyrrolidin-3-yloxy)-pyrid...)
Show SMILES Cc1cc(O[C@@H]2CCNC2)cnc1Cl
Show InChI InChI=1S/C10H13ClN2O/c1-7-4-9(6-13-10(7)11)14-8-2-3-12-5-8/h4,6,8,12H,2-3,5H2,1H3/t8-/m1/s1
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n/an/a 64n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2


Bioorg Med Chem Lett 10: 1063-6 (2000)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50088643
PNG
(2-Chloro-5-((R)-pyrrolidin-3-yloxy)-[3,4']bipyridi...)
Show SMILES Clc1ncc(O[C@@H]2CCNC2)cc1-c1ccncc1
Show InChI InChI=1S/C14H14ClN3O/c15-14-13(10-1-4-16-5-2-10)7-12(9-18-14)19-11-3-6-17-8-11/h1-2,4-5,7,9,11,17H,3,6,8H2/t11-/m1/s1
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n/an/a 65n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2


Bioorg Med Chem Lett 10: 1063-6 (2000)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50088634
PNG
(2-Chloro-3-phenyl-5-((R)-pyrrolidin-3-yloxy)-pyrid...)
Show SMILES Clc1ncc(O[C@@H]2CCNC2)cc1-c1ccccc1
Show InChI InChI=1S/C15H15ClN2O/c16-15-14(11-4-2-1-3-5-11)8-13(10-18-15)19-12-6-7-17-9-12/h1-5,8,10,12,17H,6-7,9H2/t12-/m1/s1
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n/an/a 75n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2


Bioorg Med Chem Lett 10: 1063-6 (2000)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50143298
PNG
((3aS,9bR)-1-Methyl-8-octyl-2,3,3a,4,5,9b-hexahydro...)
Show SMILES CCCCCCCC[n+]1ccc2CC[C@H]3CCN(C)[C@H]3c2c1
Show InChI InChI=1S/C20H33N2/c1-3-4-5-6-7-8-13-22-15-12-17-9-10-18-11-14-21(2)20(18)19(17)16-22/h12,15-16,18,20H,3-11,13-14H2,1-2H3/q+1/t18-,20+/m0/s1
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n/an/a 80n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against nAChR mediated nicotine-evoked [3H]-DA overflow using rat striatal slices


Bioorg Med Chem Lett 14: 1869-74 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.074
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50088632
PNG
(3-(1-Methyl-pyrrolidin-3-yloxy)-pyridine | CHEMBL1...)
Show SMILES CN1CCC(C1)Oc1cccnc1
Show InChI InChI=1S/C10H14N2O/c1-12-6-4-10(8-12)13-9-3-2-5-11-7-9/h2-3,5,7,10H,4,6,8H2,1H3
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n/an/a 92n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL




Bioorg Med Chem Lett 10: 1063-6 (2000)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50088648
PNG
(3-Bromo-2-chloro-5-((R)-pyrrolidin-3-yloxy)-pyridi...)
Show SMILES Clc1ncc(O[C@@H]2CCNC2)cc1Br
Show InChI InChI=1S/C9H10BrClN2O/c10-8-3-7(5-13-9(8)11)14-6-1-2-12-4-6/h3,5-6,12H,1-2,4H2/t6-/m1/s1
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n/an/a 94n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2


Bioorg Med Chem Lett 10: 1063-6 (2000)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50088631
PNG
(2-Chloro-3-(3-chloro-phenyl)-5-((R)-pyrrolidin-3-y...)
Show SMILES Clc1cccc(c1)-c1cc(O[C@@H]2CCNC2)cnc1Cl
Show InChI InChI=1S/C15H14Cl2N2O/c16-11-3-1-2-10(6-11)14-7-13(9-19-15(14)17)20-12-4-5-18-8-12/h1-3,6-7,9,12,18H,4-5,8H2/t12-/m1/s1
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n/an/a 103n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2


Bioorg Med Chem Lett 10: 1063-6 (2000)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50143294
PNG
(1-Icosyl-pyridinium; bromide | 1-icosylpyridinium ...)
Show SMILES CCCCCCCCCCCCCCCCCCCC[n+]1ccccc1
Show InChI InChI=1S/C25H46N/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-23-26-24-21-19-22-25-26/h19,21-22,24-25H,2-18,20,23H2,1H3/q+1
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n/an/a 120n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of [3H]-nicotine binding to Nicotinic acetylcholine receptor alpha4-beta2 in rat brain


Bioorg Med Chem Lett 14: 1869-74 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.074
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50143309
PNG
(1-Decyl-pyridinium; iodide | CHEMBL55297)
Show SMILES CCCCCCCCCC[n+]1ccccc1
Show InChI InChI=1S/C15H26N/c1-2-3-4-5-6-7-8-10-13-16-14-11-9-12-15-16/h9,11-12,14-15H,2-8,10,13H2,1H3/q+1
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n/an/a 130n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of [3H]-nicotine binding to Nicotinic acetylcholine receptor alpha4-beta2 in rat brain


Bioorg Med Chem Lett 14: 1869-74 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.074
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50088641
PNG
(2-Chloro-5-((R)-pyrrolidin-3-yloxy)-3-vinyl-pyridi...)
Show SMILES Clc1ncc(O[C@@H]2CCNC2)cc1C=C
Show InChI InChI=1S/C11H13ClN2O/c1-2-8-5-10(7-14-11(8)12)15-9-3-4-13-6-9/h2,5,7,9,13H,1,3-4,6H2/t9-/m1/s1
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n/an/a 140n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2


Bioorg Med Chem Lett 10: 1063-6 (2000)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50143304
PNG
(3-(1-methylpyrrolidin-2-yl)-1-[6-(3-(1-methylpyrro...)
Show SMILES CN1CCC[C@H]1c1ccc[n+](CCCCCCCCCCCCCC[n+]2cccc(c2)[C@@H]2CCCN2C)c1
Show InChI InChI=1S/C34H56N4/c1-35-23-17-21-33(35)31-19-15-27-37(29-31)25-13-11-9-7-5-3-4-6-8-10-12-14-26-38-28-16-20-32(30-38)34-22-18-24-36(34)2/h15-16,19-20,27-30,33-34H,3-14,17-18,21-26H2,1-2H3/q+2/t33-,34-/m0/s1
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n/an/a 170n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against nAChR mediated nicotine-evoked [3H]-DA overflow using rat striatal slices


Bioorg Med Chem Lett 14: 1869-74 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.074
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50088431
PNG
(3-(Piperidin-3-yloxy)-pyridine | 3-(piperidin-3-yl...)
Show SMILES C1CNCC(C1)Oc1cccnc1
Show InChI InChI=1S/C10H14N2O/c1-3-9(7-11-5-1)13-10-4-2-6-12-8-10/h1,3,5,7,10,12H,2,4,6,8H2
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R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2


Bioorg Med Chem Lett 10: 1063-6 (2000)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50088442
PNG
(3-(Pyrrolidin-3-yloxy)-pyridine | 3-(pyrrolidin-3-...)
Show SMILES C1CC(CN1)Oc1cccnc1
Show InChI InChI=1S/C9H12N2O/c1-2-8(6-10-4-1)12-9-3-5-11-7-9/h1-2,4,6,9,11H,3,5,7H2
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R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2


Bioorg Med Chem Lett 10: 1063-6 (2000)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50143297
PNG
((3aS,9bR)-8-Dodecyl-1-methyl-2,3,3a,4,5,9b-hexahyd...)
Show SMILES CCCCCCCCCCCC[n+]1ccc2CC[C@H]3CCN(C)[C@H]3c2c1
Show InChI InChI=1S/C24H41N2/c1-3-4-5-6-7-8-9-10-11-12-17-26-19-16-21-13-14-22-15-18-25(2)24(22)23(21)20-26/h16,19-20,22,24H,3-15,17-18H2,1-2H3/q+1/t22-,24+/m0/s1
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n/an/a 220n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against nAChR mediated nicotine-evoked [3H]-DA overflow using rat striatal slices


Bioorg Med Chem Lett 14: 1869-74 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.074
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50143308
PNG
(1-Dodecyl-pyridinium; iodide | CHEMBL540201)
Show SMILES CCCCCCCCCCCC[n+]1ccccc1
Show InChI InChI=1S/C17H30N/c1-2-3-4-5-6-7-8-9-10-12-15-18-16-13-11-14-17-18/h11,13-14,16-17H,2-10,12,15H2,1H3/q+1
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n/an/a 260n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of [3H]-nicotine binding to Nicotinic acetylcholine receptor alpha4-beta2 in rat brain


Bioorg Med Chem Lett 14: 1869-74 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.074
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50143311
PNG
((3aR,9bS)-1-Methyl-6-nonyl-2,3,3a,4,5,9b-hexahydro...)
Show SMILES CCCCCCCCC[n+]1cccc2[C@@H]3[C@@H](CCN3C)CCc12
Show InChI InChI=1S/C21H35N2/c1-3-4-5-6-7-8-9-15-23-16-10-11-19-20(23)13-12-18-14-17-22(2)21(18)19/h10-11,16,18,21H,3-9,12-15,17H2,1-2H3/q+1/t18-,21+/m1/s1
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University of Kentucky

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against nAChR mediated nicotine-evoked [3H]-DA overflow using rat striatal slices


Bioorg Med Chem Lett 14: 1869-74 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.074
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50143307
PNG
(1-Pentadecyl-pyridinium; bromide | CHEMBL55479)
Show SMILES CCCCCCCCCCCCCCC[n+]1ccccc1
Show InChI InChI=1S/C20H36N/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-21-19-16-14-17-20-21/h14,16-17,19-20H,2-13,15,18H2,1H3/q+1
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University of Kentucky

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against nAChR mediated nicotine-evoked [3H]-DA overflow using rat striatal slices


Bioorg Med Chem Lett 14: 1869-74 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.074
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50088644
PNG
(3-((S)-Pyrrolidin-3-yloxy)-pyridine | CHEMBL9957)
Show SMILES C1C[C@@H](CN1)Oc1cccnc1
Show InChI InChI=1S/C9H12N2O/c1-2-8(6-10-4-1)12-9-3-5-11-7-9/h1-2,4,6,9,11H,3,5,7H2/t9-/m0/s1
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R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2


Bioorg Med Chem Lett 10: 1063-6 (2000)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50088645
PNG
(4-[5-((R)-Pyrrolidin-3-yloxy)-pyridin-3-yl]-benzon...)
Show SMILES N#Cc1ccc(cc1)-c1cncc(O[C@@H]2CCNC2)c1
Show InChI InChI=1S/C16H15N3O/c17-8-12-1-3-13(4-2-12)14-7-16(11-19-9-14)20-15-5-6-18-10-15/h1-4,7,9,11,15,18H,5-6,10H2/t15-/m1/s1
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n/an/a 544n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2


Bioorg Med Chem Lett 10: 1063-6 (2000)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50088646
PNG
(5-((R)-Pyrrolidin-3-yloxy)-[3,4']bipyridinyl | CHE...)
Show SMILES C1C[C@H](CN1)Oc1cncc(c1)-c1ccncc1
Show InChI InChI=1S/C14H15N3O/c1-4-15-5-2-11(1)12-7-14(10-17-8-12)18-13-3-6-16-9-13/h1-2,4-5,7-8,10,13,16H,3,6,9H2/t13-/m1/s1
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n/an/a 571n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2


Bioorg Med Chem Lett 10: 1063-6 (2000)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50143299
PNG
((3aS,9bR)-8-Decyl-1-methyl-2,3,3a,4,5,9b-hexahydro...)
Show SMILES CCCCCCCCCC[n+]1ccc2CC[C@H]3CCN(C)[C@H]3c2c1
Show InChI InChI=1S/C22H37N2/c1-3-4-5-6-7-8-9-10-15-24-17-14-19-11-12-20-13-16-23(2)22(20)21(19)18-24/h14,17-18,20,22H,3-13,15-16H2,1-2H3/q+1/t20-,22+/m0/s1
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n/an/a 580n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of [3H]-nicotine binding to Nicotinic acetylcholine receptor alpha4-beta2 in rat brain


Bioorg Med Chem Lett 14: 1869-74 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.074
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50119801
PNG
((S)-3-(1-methylpyrrolidin-2-yl)-1-octylpyridinium ...)
Show SMILES CCCCCCCC[n+]1cccc(c1)[C@@H]1CCCN1C |r|
Show InChI InChI=1S/C18H31N2/c1-3-4-5-6-7-8-14-20-15-9-11-17(16-20)18-12-10-13-19(18)2/h9,11,15-16,18H,3-8,10,12-14H2,1-2H3/q+1/t18-/m0/s1
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n/an/a 620n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against nAChR mediated nicotine-evoked [3H]-DA overflow using rat striatal slices


Bioorg Med Chem Lett 14: 1869-74 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.074
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50143310
PNG
((3aS,9bR)-1-Methyl-8-nonyl-2,3,3a,4,5,9b-hexahydro...)
Show SMILES CCCCCCCCC[n+]1ccc2CC[C@H]3CCN(C)[C@H]3c2c1
Show InChI InChI=1S/C21H35N2/c1-3-4-5-6-7-8-9-14-23-16-13-18-10-11-19-12-15-22(2)21(19)20(18)17-23/h13,16-17,19,21H,3-12,14-15H2,1-2H3/q+1/t19-,21+/m0/s1
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n/an/a 660n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against nAChR mediated nicotine-evoked [3H]-DA overflow using rat striatal slices


Bioorg Med Chem Lett 14: 1869-74 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.074
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50088647
PNG
(3-((R)-Pyrrolidin-3-yloxy)-5-vinyl-pyridine | CHEM...)
Show SMILES C=Cc1cncc(O[C@@H]2CCNC2)c1
Show InChI InChI=1S/C11H14N2O/c1-2-9-5-11(8-13-6-9)14-10-3-4-12-7-10/h2,5-6,8,10,12H,1,3-4,7H2/t10-/m1/s1
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n/an/a 883n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2


Bioorg Med Chem Lett 10: 1063-6 (2000)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50088649
PNG
(3-(3-Chloro-phenyl)-5-((R)-pyrrolidin-3-yloxy)-pyr...)
Show SMILES Clc1cccc(c1)-c1cncc(O[C@@H]2CCNC2)c1
Show InChI InChI=1S/C15H15ClN2O/c16-13-3-1-2-11(6-13)12-7-15(10-18-8-12)19-14-4-5-17-9-14/h1-3,6-8,10,14,17H,4-5,9H2/t14-/m1/s1
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n/an/a 940n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2


Bioorg Med Chem Lett 10: 1063-6 (2000)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50143293
PNG
(1-[6-(pyridinium-1-yl)tetradecyl]pyridinium; Dibro...)
Show SMILES C(CCCCCCC[n+]1ccccc1)CCCCCC[n+]1ccccc1
Show InChI InChI=1S/C24H38N2/c1(3-5-7-9-13-19-25-21-15-11-16-22-25)2-4-6-8-10-14-20-26-23-17-12-18-24-26/h11-12,15-18,21-24H,1-10,13-14,19-20H2/q+2
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of [3H]-nicotine binding to Nicotinic acetylcholine receptor alpha4-beta2 in rat brain


Bioorg Med Chem Lett 14: 1869-74 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.074
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50296730
PNG
(CHEMBL563848 | phenyl 1,4-diazabicyclo[3.2.2]nonan...)
Show SMILES O=C(Oc1ccccc1)N1CCN2CCC1CC2 |TLB:1:9:14.13:16.17,(-5.08,4.31,;-5.08,2.76,;-3.74,1.99,;-2.4,2.77,;-1.06,2,;.28,2.77,;.27,4.32,;-1.08,5.09,;-2.41,4.31,;-6.42,1.98,;-6.05,.51,;-7.06,1.23,;-8.44,1.16,;-8.52,2.88,;-7.9,4.03,;-7.83,2.61,;-9.13,1.9,;-9.44,.45,)|
Show InChI InChI=1S/C14H18N2O2/c17-14(18-13-4-2-1-3-5-13)16-11-10-15-8-6-12(16)7-9-15/h1-5,12H,6-11H2
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n/an/a 1.04E+3n/an/an/an/an/an/a



Pfizer Global Research& Development

Curated by ChEMBL


Assay Description
Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration method


Bioorg Med Chem Lett 19: 4747-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.059
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50296728
PNG
(3-fluorophenyl 1,4-diazabicyclo[3.2.2]nonane-4-car...)
Show SMILES Fc1cccc(OC(=O)N2CCN3CCC2CC3)c1 |TLB:7:9:14.13:16.17,(22.94,-41.26,;21.49,-40.73,;21.22,-39.21,;19.75,-38.69,;18.58,-39.68,;18.86,-41.2,;17.68,-42.19,;16.22,-41.67,;15.95,-40.15,;15.04,-42.66,;15.41,-44.14,;14.4,-43.41,;13.02,-43.48,;12.94,-41.77,;13.56,-40.62,;13.63,-42.04,;12.33,-42.74,;12.03,-44.19,;20.3,-41.73,)|
Show InChI InChI=1S/C14H17FN2O2/c15-11-2-1-3-13(10-11)19-14(18)17-9-8-16-6-4-12(17)5-7-16/h1-3,10,12H,4-9H2
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n/an/a 1.07E+3n/an/an/an/an/an/a



Pfizer Global Research& Development

Curated by ChEMBL


Assay Description
Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration method


Bioorg Med Chem Lett 19: 4747-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.059
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50088633
PNG
(3-(3-Methoxy-phenyl)-5-((R)-pyrrolidin-3-yloxy)-py...)
Show SMILES COc1cccc(c1)-c1cncc(O[C@@H]2CCNC2)c1
Show InChI InChI=1S/C16H18N2O2/c1-19-14-4-2-3-12(7-14)13-8-16(11-18-9-13)20-15-5-6-17-10-15/h2-4,7-9,11,15,17H,5-6,10H2,1H3/t15-/m1/s1
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n/an/a 1.12E+3n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2


Bioorg Med Chem Lett 10: 1063-6 (2000)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50296729
PNG
(4-fluorophenyl 1,4-diazabicyclo[3.2.2]nonane-4-car...)
Show SMILES Fc1ccc(OC(=O)N2CCN3CCC2CC3)cc1 |TLB:6:8:13.12:15.16,(12,-37.68,;10.82,-38.68,;11.09,-40.2,;9.91,-41.19,;8.46,-40.66,;7.28,-41.66,;5.83,-41.13,;5.56,-39.61,;4.65,-42.13,;5.01,-43.6,;4.01,-42.88,;2.62,-42.95,;2.55,-41.24,;3.17,-40.08,;3.23,-41.5,;1.93,-42.21,;1.63,-43.65,;8.19,-39.15,;9.36,-38.15,)|
Show InChI InChI=1S/C14H17FN2O2/c15-11-1-3-13(4-2-11)19-14(18)17-10-9-16-7-5-12(17)6-8-16/h1-4,12H,5-10H2
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n/an/a 1.78E+3n/an/an/an/an/an/a



Pfizer Global Research& Development

Curated by ChEMBL


Assay Description
Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration method


Bioorg Med Chem Lett 19: 4747-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.059
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50088642
PNG
(3-Phenyl-5-((R)-pyrrolidin-3-yloxy)-pyridine | CHE...)
Show SMILES C1C[C@H](CN1)Oc1cncc(c1)-c1ccccc1
Show InChI InChI=1S/C15H16N2O/c1-2-4-12(5-3-1)13-8-15(11-17-9-13)18-14-6-7-16-10-14/h1-5,8-9,11,14,16H,6-7,10H2/t14-/m1/s1
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n/an/a 1.82E+3n/an/an/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2


Bioorg Med Chem Lett 10: 1063-6 (2000)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50296747
PNG
(3-benzoyl-4-bromophenyl 1,4-diazabicyclo[3.2.2]non...)
Show SMILES Brc1ccc(OC(=O)N2CCN3CCC2CC3)cc1C(=O)c1ccccc1 |TLB:6:8:13.12:15.16,(17.84,-19.26,;16.66,-20.26,;15.15,-19.71,;13.93,-20.75,;14.21,-22.32,;12.98,-23.35,;11.48,-22.81,;11.19,-21.22,;10.25,-23.84,;10.63,-25.37,;9.59,-24.62,;8.15,-24.69,;8.06,-22.92,;8.71,-21.72,;8.78,-23.2,;7.43,-23.93,;7.12,-25.43,;15.72,-22.87,;16.95,-21.84,;18.39,-22.36,;18.66,-23.88,;19.57,-21.37,;21.02,-21.91,;22.19,-20.92,;21.93,-19.4,;20.47,-18.88,;19.3,-19.87,)|
Show InChI InChI=1S/C21H21BrN2O3/c22-19-7-6-17(14-18(19)20(25)15-4-2-1-3-5-15)27-21(26)24-13-12-23-10-8-16(24)9-11-23/h1-7,14,16H,8-13H2
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n/an/a 2.04E+3n/an/an/an/an/an/a



Pfizer Global Research& Development

Curated by ChEMBL


Assay Description
Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration method


Bioorg Med Chem Lett 19: 4747-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.059
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50296717
PNG
(3-benzoylphenyl 1,4-diazabicyclo[3.2.2]nonane-4-ca...)
Show SMILES O=C(Oc1cccc(c1)C(=O)c1ccccc1)N1CCN2CCC1CC2 |TLB:1:17:22.21:24.25,(27.34,-3.85,;27.34,-5.38,;28.68,-6.15,;30.01,-5.38,;30,-3.85,;31.33,-3.07,;32.68,-3.84,;32.68,-5.38,;31.34,-6.15,;34.01,-6.15,;35.34,-5.38,;34.01,-7.69,;32.67,-8.46,;32.67,-10,;34.01,-10.77,;35.34,-10,;35.34,-8.46,;26.01,-6.15,;26.12,-7.67,;25.25,-6.78,;23.88,-6.61,;24.1,-4.92,;24.91,-3.89,;24.73,-5.3,;23.33,-5.76,;22.79,-7.14,)|
Show InChI InChI=1S/C21H22N2O3/c24-20(16-5-2-1-3-6-16)17-7-4-8-19(15-17)26-21(25)23-14-13-22-11-9-18(23)10-12-22/h1-8,15,18H,9-14H2
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n/an/a 2.62E+3n/an/an/an/an/an/a



Pfizer Global Research& Development

Curated by ChEMBL


Assay Description
Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration method


Bioorg Med Chem Lett 19: 4747-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.059
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50296726
PNG
(3-chlorophenyl 1,4-diazabicyclo[3.2.2]nonane-4-car...)
Show SMILES Clc1cccc(OC(=O)N2CCN3CCC2CC3)c1 |TLB:7:9:14.13:16.17,(2.4,-48.55,;.95,-48.03,;.68,-46.5,;-.79,-45.98,;-1.96,-46.98,;-1.68,-48.49,;-2.86,-49.49,;-4.32,-48.96,;-4.59,-47.44,;-5.5,-49.95,;-5.13,-51.43,;-6.14,-50.71,;-7.52,-50.77,;-7.6,-49.07,;-6.98,-47.91,;-6.91,-49.33,;-8.21,-50.04,;-8.51,-51.48,;-.24,-49.02,)|
Show InChI InChI=1S/C14H17ClN2O2/c15-11-2-1-3-13(10-11)19-14(18)17-9-8-16-6-4-12(17)5-7-16/h1-3,10,12H,4-9H2
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n/an/a 3.51E+3n/an/an/an/an/an/a



Pfizer Global Research& Development

Curated by ChEMBL


Assay Description
Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration method


Bioorg Med Chem Lett 19: 4747-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.059
More data for this
Ligand-Target Pair
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