Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM19440 (1-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer | Assay Description Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor... | J Med Chem 50: 5712-9 (2007) Article DOI: 10.1021/jm0611915 BindingDB Entry DOI: 10.7270/Q20G3HD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM19439 (1-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer | Assay Description Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor... | J Med Chem 50: 5712-9 (2007) Article DOI: 10.1021/jm0611915 BindingDB Entry DOI: 10.7270/Q20G3HD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM19435 (1-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer | Assay Description Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor... | J Med Chem 50: 5712-9 (2007) Article DOI: 10.1021/jm0611915 BindingDB Entry DOI: 10.7270/Q20G3HD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM19430 (1-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer | Assay Description Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor... | J Med Chem 50: 5712-9 (2007) Article DOI: 10.1021/jm0611915 BindingDB Entry DOI: 10.7270/Q20G3HD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM19438 (4-{5-[(8aS)-octahydropyrrolo[1,2-a]piperazin-2-yl]...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 62 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer | Assay Description Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor... | J Med Chem 50: 5712-9 (2007) Article DOI: 10.1021/jm0611915 BindingDB Entry DOI: 10.7270/Q20G3HD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM19437 (1-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer | Assay Description Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor... | J Med Chem 50: 5712-9 (2007) Article DOI: 10.1021/jm0611915 BindingDB Entry DOI: 10.7270/Q20G3HD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM19431 (4-[3-(4-chlorophenyl)-5-(3,5-dimethylpiperidin-1-y...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 130 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer | Assay Description Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor... | J Med Chem 50: 5712-9 (2007) Article DOI: 10.1021/jm0611915 BindingDB Entry DOI: 10.7270/Q20G3HD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM19432 (4-[3-(4-chlorophenyl)-5-(4-methylpiperidin-1-yl)-1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 130 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer | Assay Description Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor... | J Med Chem 50: 5712-9 (2007) Article DOI: 10.1021/jm0611915 BindingDB Entry DOI: 10.7270/Q20G3HD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM19436 (1-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 190 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer | Assay Description Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor... | J Med Chem 50: 5712-9 (2007) Article DOI: 10.1021/jm0611915 BindingDB Entry DOI: 10.7270/Q20G3HD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM19434 (2-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 190 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer | Assay Description Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor... | J Med Chem 50: 5712-9 (2007) Article DOI: 10.1021/jm0611915 BindingDB Entry DOI: 10.7270/Q20G3HD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM19433 (2-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 260 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer | Assay Description Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor... | J Med Chem 50: 5712-9 (2007) Article DOI: 10.1021/jm0611915 BindingDB Entry DOI: 10.7270/Q20G3HD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM19429 (4-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]pyridine | S...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Patents | DrugBank PDB Article PubMed | n/a | n/a | 600 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Pfizer | Assay Description Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor... | J Med Chem 50: 5712-9 (2007) Article DOI: 10.1021/jm0611915 BindingDB Entry DOI: 10.7270/Q20G3HD5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |