Compile Data Set for Download or QSAR

Found 52 hits Enz. Inhib. hit(s) with all data for entry = 2410   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM19992 (2-[3-[3-[[2-chloro-3-(trifluoromethyl)phenyl]methy...) Show SMILES OC(=O)Cc1cccc(OCCCN(CC(c2ccccc2)c2ccccc2)Cc2cccc(c2Cl)C(F)(F)F)c1 Show InChI InChI=1S/C33H31ClF3NO3/c34-32-27(15-8-17-30(32)33(35,36)37)22-38(18-9-19-41-28-16-7-10-24(20-28)21-31(39)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26/h1-8,10-17,20,29H,9,18-19,21-23H2,(H,39,40)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description SPA assays were run in displacement mode using 30 nM [3H]-GW3965. Ligands were tested in 12-point dose-response curves starting at 20 uM. IC50 values...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair				3D Structure (crystal)
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM20132 ((2R)-5-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-3-...) Show SMILES COc1cccc([C@H]2SC(=NN2C(=O)c2c(F)cc(F)cc2F)c2ccc(Cl)cc2)c1OC |r,c:9| Show InChI InChI=1S/C23H16ClF3N2O3S/c1-31-18-5-3-4-15(20(18)32-2)23-29(22(30)19-16(26)10-14(25)11-17(19)27)28-21(33-23)12-6-8-13(24)9-7-12/h3-11,23H,1-2H3/t23-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description SPA assays were run in displacement mode using 30 nM [3H]-GW3965. Ligands were tested in 12-point dose-response curves starting at 20 uM. IC50 values...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM19992 (2-[3-[3-[[2-chloro-3-(trifluoromethyl)phenyl]methy...) Show SMILES OC(=O)Cc1cccc(OCCCN(CC(c2ccccc2)c2ccccc2)Cc2cccc(c2Cl)C(F)(F)F)c1 Show InChI InChI=1S/C33H31ClF3NO3/c34-32-27(15-8-17-30(32)33(35,36)37)22-38(18-9-19-41-28-16-7-10-24(20-28)21-31(39)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26/h1-8,10-17,20,29H,9,18-19,21-23H2,(H,39,40)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	121	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description SPA assays were run in displacement mode using 30 nM [3H]-GW3965. Ligands were tested in 12-point dose-response curves starting at 20 uM. IC50 values...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair				3D Structure (crystal)
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM20131 (5-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-3-[(2,4...) Show SMILES COc1cccc(C2SC(=NN2C(=O)c2c(F)cc(F)cc2F)c2ccc(Cl)cc2)c1OC |c:9| Show InChI InChI=1S/C23H16ClF3N2O3S/c1-31-18-5-3-4-15(20(18)32-2)23-29(22(30)19-16(26)10-14(25)11-17(19)27)28-21(33-23)12-6-8-13(24)9-7-12/h3-11,23H,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description SPA assays were run in displacement mode using 30 nM [3H]-GW3965. Ligands were tested in 12-point dose-response curves starting at 20 uM. IC50 values...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM20132 ((2R)-5-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-3-...) Show SMILES COc1cccc([C@H]2SC(=NN2C(=O)c2c(F)cc(F)cc2F)c2ccc(Cl)cc2)c1OC |r,c:9| Show InChI InChI=1S/C23H16ClF3N2O3S/c1-31-18-5-3-4-15(20(18)32-2)23-29(22(30)19-16(26)10-14(25)11-17(19)27)28-21(33-23)12-6-8-13(24)9-7-12/h3-11,23H,1-2H3/t23-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description SPA assays were run in displacement mode using 30 nM [3H]-GW3965. Ligands were tested in 12-point dose-response curves starting at 20 uM. IC50 values...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM20131 (5-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-3-[(2,4...) Show SMILES COc1cccc(C2SC(=NN2C(=O)c2c(F)cc(F)cc2F)c2ccc(Cl)cc2)c1OC |c:9| Show InChI InChI=1S/C23H16ClF3N2O3S/c1-31-18-5-3-4-15(20(18)32-2)23-29(22(30)19-16(26)10-14(25)11-17(19)27)28-21(33-23)12-6-8-13(24)9-7-12/h3-11,23H,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description SPA assays were run in displacement mode using 30 nM [3H]-GW3965. Ligands were tested in 12-point dose-response curves starting at 20 uM. IC50 values...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM20136 (2-(4-fluoro-2-methoxyphenyl)-5-(4-fluorophenyl)-3-...) Show SMILES COc1cc(F)ccc1C1SC(=NN1C(=O)c1c(F)cc(F)cc1F)c1ccc(F)cc1 |c:12| Show InChI InChI=1S/C22H13F5N2O2S/c1-31-18-10-13(24)6-7-15(18)22-29(21(30)19-16(26)8-14(25)9-17(19)27)28-20(32-22)11-2-4-12(23)5-3-11/h2-10,22H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	70	n/a	n/a	7.2	37
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM20137 (2-[2-(difluoromethoxy)phenyl]-5-(4-fluorophenyl)-3...) Show SMILES FC(F)Oc1ccccc1C1SC(=NN1C(=O)c1c(F)cc(F)cc1F)c1ccc(F)cc1 |c:13| Show InChI InChI=1S/C22H12F6N2O2S/c23-12-7-5-11(6-8-12)19-29-30(20(31)18-15(25)9-13(24)10-16(18)26)21(33-19)14-3-1-2-4-17(14)32-22(27)28/h1-10,21-22H	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.90E+3	n/a	n/a	7.2	37
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM20138 (5-(4-chlorophenyl)-2-(2,2-difluoro-2H-1,3-benzodio...) Show SMILES Fc1cc(F)c(C(=O)N2N=C(SC2c2cccc3OC(F)(F)Oc23)c2ccc(Cl)cc2)c(F)c1 |c:9| Show InChI InChI=1S/C22H10ClF5N2O3S/c23-11-6-4-10(5-7-11)19-29-30(20(31)17-14(25)8-12(24)9-15(17)26)21(34-19)13-2-1-3-16-18(13)33-22(27,28)32-16/h1-9,21H	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.90E+3	n/a	n/a	7.2	37
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM20139 (5-(4-fluorophenyl)-2-(2-methoxypyridin-3-yl)-3-[(2...) Show SMILES COc1ncccc1C1SC(=NN1C(=O)c1c(F)cc(F)cc1F)c1ccc(F)cc1 |c:11| Show InChI InChI=1S/C21H13F4N3O2S/c1-30-18-14(3-2-8-26-18)21-28(20(29)17-15(24)9-13(23)10-16(17)25)27-19(31-21)11-4-6-12(22)7-5-11/h2-10,21H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	400	n/a	n/a	7.2	37
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM20140 (5-(4-chlorophenyl)-3-[(2,4-difluorophenyl)carbonyl...) Show SMILES COc1cccc(C2SC(=NN2C(=O)c2ccc(F)cc2F)c2ccc(Cl)cc2)c1OC |c:9| Show InChI InChI=1S/C23H17ClF2N2O3S/c1-30-19-5-3-4-17(20(19)31-2)23-28(22(29)16-11-10-15(25)12-18(16)26)27-21(32-23)13-6-8-14(24)9-7-13/h3-12,23H,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.70E+3	n/a	n/a	7.2	37
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM20141 (5-(3,4-difluorophenyl)-2-(2,3-dimethoxyphenyl)-3-[...) Show SMILES COc1cccc(C2SC(=NN2C(=O)c2cccc(F)c2)c2ccc(F)c(F)c2)c1OC |c:9| Show InChI InChI=1S/C23H17F3N2O3S/c1-30-19-8-4-7-16(20(19)31-2)23-28(22(29)14-5-3-6-15(24)11-14)27-21(32-23)13-9-10-17(25)18(26)12-13/h3-12,23H,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.50E+3	n/a	n/a	7.2	37
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM20142 (3-[(3,5-difluorophenyl)carbonyl]-2-(2,3-dimethoxyp...) Show SMILES COc1cccc(C2SC(=NN2C(=O)c2cc(F)cc(F)c2)c2ccc(F)cc2)c1OC |c:9| Show InChI InChI=1S/C23H17F3N2O3S/c1-30-19-5-3-4-18(20(19)31-2)23-28(22(29)14-10-16(25)12-17(26)11-14)27-21(32-23)13-6-8-15(24)9-7-13/h3-12,23H,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.10E+3	n/a	n/a	7.2	37
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM20143 (2-(2,3-dimethoxyphenyl)-3-[(5-fluoro-2-methylpheny...) Show SMILES COc1cccc(C2SC(=NN2C(=O)c2cc(F)ccc2C)c2ccc(F)cc2)c1OC |c:9| Show InChI InChI=1S/C24H20F2N2O3S/c1-14-7-10-17(26)13-19(14)23(29)28-24(18-5-4-6-20(30-2)21(18)31-3)32-22(27-28)15-8-11-16(25)12-9-15/h4-13,24H,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.40E+3	n/a	n/a	7.2	37
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM20144 (3-[(2,6-difluoro-4-methoxyphenyl)carbonyl]-2-(2,3-...) Show SMILES COc1cc(F)c(C(=O)N2N=C(SC2c2cccc(OC)c2OC)c2ccc(F)cc2)c(F)c1 |c:10| Show InChI InChI=1S/C24H19F3N2O4S/c1-31-15-11-17(26)20(18(27)12-15)23(30)29-24(16-5-4-6-19(32-2)21(16)33-3)34-22(28-29)13-7-9-14(25)10-8-13/h4-12,24H,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	900	n/a	n/a	7.2	37
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM20145 (3-[(4-bromo-2,6-difluorophenyl)carbonyl]-2-(2,3-di...) Show SMILES COc1cccc(C2SC(=NN2C(=O)c2c(F)cc(Br)cc2F)c2ccc(F)cc2)c1OC |c:9| Show InChI InChI=1S/C23H16BrF3N2O3S/c1-31-18-5-3-4-15(20(18)32-2)23-29(22(30)19-16(26)10-13(24)11-17(19)27)28-21(33-23)12-6-8-14(25)9-7-12/h3-11,23H,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	900	n/a	n/a	7.2	37
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM20146 (2-(2,3-dimethoxyphenyl)-5-(4-fluorophenyl)-3-[(2,4...) Show SMILES COc1cccc(C2SC(=NN2C(=O)c2cc(F)c(F)c(OC)c2F)c2ccc(F)cc2)c1OC |c:9| Show InChI InChI=1S/C24H18F4N2O4S/c1-32-17-6-4-5-14(20(17)33-2)24-30(29-22(35-24)12-7-9-13(25)10-8-12)23(31)15-11-16(26)19(28)21(34-3)18(15)27/h4-11,24H,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	700	n/a	n/a	7.2	37
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM19992 (2-[3-[3-[[2-chloro-3-(trifluoromethyl)phenyl]methy...) Show SMILES OC(=O)Cc1cccc(OCCCN(CC(c2ccccc2)c2ccccc2)Cc2cccc(c2Cl)C(F)(F)F)c1 Show InChI InChI=1S/C33H31ClF3NO3/c34-32-27(15-8-17-30(32)33(35,36)37)22-38(18-9-19-41-28-16-7-10-24(20-28)21-31(39)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26/h1-8,10-17,20,29H,9,18-19,21-23H2,(H,39,40)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	27	n/a	n/a	7.2	37
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair				3D Structure (crystal)
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM20131 (5-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-3-[(2,4...) Show SMILES COc1cccc(C2SC(=NN2C(=O)c2c(F)cc(F)cc2F)c2ccc(Cl)cc2)c1OC |c:9| Show InChI InChI=1S/C23H16ClF3N2O3S/c1-31-18-5-3-4-15(20(18)32-2)23-29(22(30)19-16(26)10-14(25)11-17(19)27)28-21(33-23)12-6-8-13(24)9-7-12/h3-11,23H,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	300	n/a	n/a	7.2	37
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM20132 ((2R)-5-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-3-...) Show SMILES COc1cccc([C@H]2SC(=NN2C(=O)c2c(F)cc(F)cc2F)c2ccc(Cl)cc2)c1OC |r,c:9| Show InChI InChI=1S/C23H16ClF3N2O3S/c1-31-18-5-3-4-15(20(18)32-2)23-29(22(30)19-16(26)10-14(25)11-17(19)27)28-21(33-23)12-6-8-13(24)9-7-12/h3-11,23H,1-2H3/t23-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	67	n/a	n/a	7.2	37
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM20133 (2-(2,3-dimethoxyphenyl)-5-(4-fluorophenyl)-3-[(2,4...) Show SMILES COc1cccc(C2SC(=NN2C(=O)c2c(F)cc(F)cc2F)c2ccc(F)cc2)c1OC |c:9| Show InChI InChI=1S/C23H16F4N2O3S/c1-31-18-5-3-4-15(20(18)32-2)23-29(22(30)19-16(26)10-14(25)11-17(19)27)28-21(33-23)12-6-8-13(24)9-7-12/h3-11,23H,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	76	n/a	n/a	7.2	37
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM20134 (2-(2,3-dimethoxyphenyl)-5-(4-methylphenyl)-3-[(2,4...) Show SMILES COc1cccc(C2SC(=NN2C(=O)c2c(F)cc(F)cc2F)c2ccc(C)cc2)c1OC |c:9| Show InChI InChI=1S/C24H19F3N2O3S/c1-13-7-9-14(10-8-13)22-28-29(23(30)20-17(26)11-15(25)12-18(20)27)24(33-22)16-5-4-6-19(31-2)21(16)32-3/h4-12,24H,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	200	n/a	n/a	7.2	37
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM20147 (5-(3,4-dichlorophenyl)-2-(2,3-dimethoxyphenyl)-3-[...) Show SMILES COc1cccc(C2SC(=NN2C(=O)c2c(F)cc(F)cc2F)c2ccc(Cl)c(Cl)c2)c1OC |c:9| Show InChI InChI=1S/C23H15Cl2F3N2O3S/c1-32-18-5-3-4-13(20(18)33-2)23-30(22(31)19-16(27)9-12(26)10-17(19)28)29-21(34-23)11-6-7-14(24)15(25)8-11/h3-10,23H,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	7.2	37
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM20135 (5-(4-chlorophenyl)-2-(2-methoxyphenyl)-3-[(2,4,6-t...) Show SMILES COc1ccccc1C1SC(=NN1C(=O)c1c(F)cc(F)cc1F)c1ccc(Cl)cc1 |c:11| Show InChI InChI=1S/C22H14ClF3N2O2S/c1-30-18-5-3-2-4-15(18)22-28(21(29)19-16(25)10-14(24)11-17(19)26)27-20(31-22)12-6-8-13(23)9-7-12/h2-11,22H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	35	n/a	n/a	7.2	37
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM20148 (5-(4-chlorophenyl)-2-(3-methoxyphenyl)-3-[(2,4,6-t...) Show SMILES COc1cccc(c1)C1SC(=NN1C(=O)c1c(F)cc(F)cc1F)c1ccc(Cl)cc1 |c:11| Show InChI InChI=1S/C22H14ClF3N2O2S/c1-30-16-4-2-3-13(9-16)22-28(21(29)19-17(25)10-15(24)11-18(19)26)27-20(31-22)12-5-7-14(23)8-6-12/h2-11,22H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.70E+3	n/a	n/a	7.2	37
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM20136 (2-(4-fluoro-2-methoxyphenyl)-5-(4-fluorophenyl)-3-...) Show SMILES COc1cc(F)ccc1C1SC(=NN1C(=O)c1c(F)cc(F)cc1F)c1ccc(F)cc1 |c:12| Show InChI InChI=1S/C22H13F5N2O2S/c1-31-18-10-13(24)6-7-15(18)22-29(21(30)19-16(26)8-14(25)9-17(19)27)28-20(32-22)11-2-4-12(23)5-3-11/h2-10,22H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	6	n/a	n/a	7.2	37
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM20149 (5-(4-chlorophenyl)-2-[2-(trifluoromethoxy)phenyl]-...) Show SMILES Fc1cc(F)c(C(=O)N2N=C(SC2c2ccccc2OC(F)(F)F)c2ccc(Cl)cc2)c(F)c1 |c:9| Show InChI InChI=1S/C22H11ClF6N2O2S/c23-12-7-5-11(6-8-12)19-30-31(20(32)18-15(25)9-13(24)10-16(18)26)21(34-19)14-3-1-2-4-17(14)33-22(27,28)29/h1-10,21H	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.40E+3	n/a	n/a	7.2	37
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM20137 (2-[2-(difluoromethoxy)phenyl]-5-(4-fluorophenyl)-3...) Show SMILES FC(F)Oc1ccccc1C1SC(=NN1C(=O)c1c(F)cc(F)cc1F)c1ccc(F)cc1 |c:13| Show InChI InChI=1S/C22H12F6N2O2S/c23-12-7-5-11(6-8-12)19-29-30(20(31)18-15(25)9-13(24)10-16(18)26)21(33-19)14-3-1-2-4-17(14)32-22(27)28/h1-10,21-22H	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	150	n/a	n/a	7.2	37
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM20138 (5-(4-chlorophenyl)-2-(2,2-difluoro-2H-1,3-benzodio...) Show SMILES Fc1cc(F)c(C(=O)N2N=C(SC2c2cccc3OC(F)(F)Oc23)c2ccc(Cl)cc2)c(F)c1 |c:9| Show InChI InChI=1S/C22H10ClF5N2O3S/c23-11-6-4-10(5-7-11)19-29-30(20(31)17-14(25)8-12(24)9-15(17)26)21(34-19)13-2-1-3-16-18(13)33-22(27,28)32-16/h1-9,21H	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	800	n/a	n/a	7.2	37
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM20139 (5-(4-fluorophenyl)-2-(2-methoxypyridin-3-yl)-3-[(2...) Show SMILES COc1ncccc1C1SC(=NN1C(=O)c1c(F)cc(F)cc1F)c1ccc(F)cc1 |c:11| Show InChI InChI=1S/C21H13F4N3O2S/c1-30-18-14(3-2-8-26-18)21-28(20(29)17-15(24)9-13(23)10-16(17)25)27-19(31-21)11-4-6-12(22)7-5-11/h2-10,21H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	210	n/a	n/a	7.2	37
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM20150 (5-(4-fluorophenyl)-2-(2-methoxyphenyl)-2-methyl-3-...) Show SMILES COc1ccccc1C1(C)SC(=NN1C(=O)c1c(F)cc(F)cc1F)c1ccc(F)cc1 |c:12| Show InChI InChI=1S/C23H16F4N2O2S/c1-23(16-5-3-4-6-19(16)31-2)29(22(30)20-17(26)11-15(25)12-18(20)27)28-21(32-23)13-7-9-14(24)10-8-13/h3-12H,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM20151 (5-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-3-[(2-f...) Show SMILES COc1cccc(C2SC(=NN2C(=O)c2ccccc2F)c2ccc(Cl)cc2)c1OC |c:9| Show InChI InChI=1S/C23H18ClFN2O3S/c1-29-19-9-5-7-17(20(19)30-2)23-27(22(28)16-6-3-4-8-18(16)25)26-21(31-23)14-10-12-15(24)13-11-14/h3-13,23H,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.70E+3	n/a	n/a	n/a	n/a
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM20140 (5-(4-chlorophenyl)-3-[(2,4-difluorophenyl)carbonyl...) Show SMILES COc1cccc(C2SC(=NN2C(=O)c2ccc(F)cc2F)c2ccc(Cl)cc2)c1OC |c:9| Show InChI InChI=1S/C23H17ClF2N2O3S/c1-30-19-5-3-4-17(20(19)31-2)23-28(22(29)16-11-10-15(25)12-18(16)26)27-21(32-23)13-6-8-14(24)9-7-13/h3-12,23H,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	980	n/a	n/a	n/a	n/a
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM20152 (2-(2,3-dimethoxyphenyl)-5-(4-fluorophenyl)-3-[(2,3...) Show SMILES COc1cccc(C2SC(=NN2C(=O)c2c(F)ccc(F)c2F)c2ccc(F)cc2)c1OC |c:9| Show InChI InChI=1S/C23H16F4N2O3S/c1-31-17-5-3-4-14(20(17)32-2)23-29(22(30)18-15(25)10-11-16(26)19(18)27)28-21(33-23)12-6-8-13(24)9-7-12/h3-11,23H,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	970	n/a	n/a	n/a	n/a
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM20153 (2-(2,3-dimethoxyphenyl)-5-(4-fluorophenyl)-3-[(2,4...) Show SMILES COc1cccc(C2SC(=NN2C(=O)c2cc(F)c(F)cc2F)c2ccc(F)cc2)c1OC |c:9| Show InChI InChI=1S/C23H16F4N2O3S/c1-31-19-5-3-4-14(20(19)32-2)23-29(22(30)15-10-17(26)18(27)11-16(15)25)28-21(33-23)12-6-8-13(24)9-7-12/h3-11,23H,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	600	n/a	n/a	n/a	n/a
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM20141 (5-(3,4-difluorophenyl)-2-(2,3-dimethoxyphenyl)-3-[...) Show SMILES COc1cccc(C2SC(=NN2C(=O)c2cccc(F)c2)c2ccc(F)c(F)c2)c1OC |c:9| Show InChI InChI=1S/C23H17F3N2O3S/c1-30-19-8-4-7-16(20(19)31-2)23-28(22(29)14-5-3-6-15(24)11-14)27-21(32-23)13-9-10-17(25)18(26)12-13/h3-12,23H,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	560	n/a	n/a	n/a	n/a
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM20142 (3-[(3,5-difluorophenyl)carbonyl]-2-(2,3-dimethoxyp...) Show SMILES COc1cccc(C2SC(=NN2C(=O)c2cc(F)cc(F)c2)c2ccc(F)cc2)c1OC |c:9| Show InChI InChI=1S/C23H17F3N2O3S/c1-30-19-5-3-4-18(20(19)31-2)23-28(22(29)14-10-16(25)12-17(26)11-14)27-21(32-23)13-6-8-15(24)9-7-13/h3-12,23H,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	470	n/a	n/a	n/a	n/a
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM20154 (3-[(3-chlorophenyl)carbonyl]-2-(2,3-dimethoxypheny...) Show SMILES COc1cccc(C2SC(=NN2C(=O)c2cccc(Cl)c2)c2ccc(F)cc2)c1OC |c:9| Show InChI InChI=1S/C23H18ClFN2O3S/c1-29-19-8-4-7-18(20(19)30-2)23-27(22(28)15-5-3-6-16(24)13-15)26-21(31-23)14-9-11-17(25)12-10-14/h3-13,23H,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	250	n/a	n/a	n/a	n/a
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM20143 (2-(2,3-dimethoxyphenyl)-3-[(5-fluoro-2-methylpheny...) Show SMILES COc1cccc(C2SC(=NN2C(=O)c2cc(F)ccc2C)c2ccc(F)cc2)c1OC |c:9| Show InChI InChI=1S/C24H20F2N2O3S/c1-14-7-10-17(26)13-19(14)23(29)28-24(18-5-4-6-20(30-2)21(18)31-3)32-22(27-28)15-8-11-16(25)12-9-15/h4-13,24H,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	140	n/a	n/a	n/a	n/a
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM20144 (3-[(2,6-difluoro-4-methoxyphenyl)carbonyl]-2-(2,3-...) Show SMILES COc1cc(F)c(C(=O)N2N=C(SC2c2cccc(OC)c2OC)c2ccc(F)cc2)c(F)c1 |c:10| Show InChI InChI=1S/C24H19F3N2O4S/c1-31-15-11-17(26)20(18(27)12-15)23(30)29-24(16-5-4-6-19(32-2)21(16)33-3)34-22(28-29)13-7-9-14(25)10-8-13/h4-12,24H,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	170	n/a	n/a	n/a	n/a
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM20145 (3-[(4-bromo-2,6-difluorophenyl)carbonyl]-2-(2,3-di...) Show SMILES COc1cccc(C2SC(=NN2C(=O)c2c(F)cc(Br)cc2F)c2ccc(F)cc2)c1OC |c:9| Show InChI InChI=1S/C23H16BrF3N2O3S/c1-31-18-5-3-4-15(20(18)32-2)23-29(22(30)19-16(26)10-13(24)11-17(19)27)28-21(33-23)12-6-8-14(25)9-7-12/h3-11,23H,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	160	n/a	n/a	n/a	n/a
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM20146 (2-(2,3-dimethoxyphenyl)-5-(4-fluorophenyl)-3-[(2,4...) Show SMILES COc1cccc(C2SC(=NN2C(=O)c2cc(F)c(F)c(OC)c2F)c2ccc(F)cc2)c1OC |c:9| Show InChI InChI=1S/C24H18F4N2O4S/c1-32-17-6-4-5-14(20(17)33-2)24-30(29-22(35-24)12-7-9-13(25)10-8-12)23(31)15-11-16(26)19(28)21(34-3)18(15)27/h4-11,24H,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	81	n/a	n/a	n/a	n/a
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM20155 ((2S)-5-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-3-...) Show SMILES COc1cccc([C@@H]2SC(=NN2C(=O)c2c(F)cc(F)cc2F)c2ccc(Cl)cc2)c1OC |r,c:9| Show InChI InChI=1S/C23H16ClF3N2O3S/c1-31-18-5-3-4-15(20(18)32-2)23-29(22(30)19-16(26)10-14(25)11-17(19)27)28-21(33-23)12-6-8-13(24)9-7-12/h3-11,23H,1-2H3/t23-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description SPA assays were run in displacement mode using 30 nM [3H]-GW3965. Ligands were tested in 12-point dose-response curves starting at 20 uM. IC50 values...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM20155 ((2S)-5-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-3-...) Show SMILES COc1cccc([C@@H]2SC(=NN2C(=O)c2c(F)cc(F)cc2F)c2ccc(Cl)cc2)c1OC |r,c:9| Show InChI InChI=1S/C23H16ClF3N2O3S/c1-31-18-5-3-4-15(20(18)32-2)23-29(22(30)19-16(26)10-14(25)11-17(19)27)28-21(33-23)12-6-8-13(24)9-7-12/h3-11,23H,1-2H3/t23-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description SPA assays were run in displacement mode using 30 nM [3H]-GW3965. Ligands were tested in 12-point dose-response curves starting at 20 uM. IC50 values...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM20155 ((2S)-5-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-3-...) Show SMILES COc1cccc([C@@H]2SC(=NN2C(=O)c2c(F)cc(F)cc2F)c2ccc(Cl)cc2)c1OC |r,c:9| Show InChI InChI=1S/C23H16ClF3N2O3S/c1-31-18-5-3-4-15(20(18)32-2)23-29(22(30)19-16(26)10-14(25)11-17(19)27)28-21(33-23)12-6-8-13(24)9-7-12/h3-11,23H,1-2H3/t23-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM20135 (5-(4-chlorophenyl)-2-(2-methoxyphenyl)-3-[(2,4,6-t...) Show SMILES COc1ccccc1C1SC(=NN1C(=O)c1c(F)cc(F)cc1F)c1ccc(Cl)cc1 |c:11| Show InChI InChI=1S/C22H14ClF3N2O2S/c1-30-18-5-3-2-4-15(18)22-28(21(29)19-16(25)10-14(24)11-17(19)26)27-20(31-22)12-6-8-13(23)9-7-12/h2-11,22H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	180	n/a	n/a	7.2	37
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM20134 (2-(2,3-dimethoxyphenyl)-5-(4-methylphenyl)-3-[(2,4...) Show SMILES COc1cccc(C2SC(=NN2C(=O)c2c(F)cc(F)cc2F)c2ccc(C)cc2)c1OC |c:9| Show InChI InChI=1S/C24H19F3N2O3S/c1-13-7-9-14(10-8-13)22-28-29(23(30)20-17(26)11-15(25)12-18(20)27)24(33-22)16-5-4-6-19(31-2)21(16)32-3/h4-12,24H,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.40E+3	n/a	n/a	7.2	37
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM20133 (2-(2,3-dimethoxyphenyl)-5-(4-fluorophenyl)-3-[(2,4...) Show SMILES COc1cccc(C2SC(=NN2C(=O)c2c(F)cc(F)cc2F)c2ccc(F)cc2)c1OC |c:9| Show InChI InChI=1S/C23H16F4N2O3S/c1-31-18-5-3-4-15(20(18)32-2)23-29(22(30)19-16(26)10-14(25)11-17(19)27)28-21(33-23)12-6-8-13(24)9-7-12/h3-11,23H,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.40E+3	n/a	n/a	7.2	37
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM20132 ((2R)-5-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-3-...) Show SMILES COc1cccc([C@H]2SC(=NN2C(=O)c2c(F)cc(F)cc2F)c2ccc(Cl)cc2)c1OC |r,c:9| Show InChI InChI=1S/C23H16ClF3N2O3S/c1-31-18-5-3-4-15(20(18)32-2)23-29(22(30)19-16(26)10-14(25)11-17(19)27)28-21(33-23)12-6-8-13(24)9-7-12/h3-11,23H,1-2H3/t23-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.60E+3	n/a	n/a	7.2	37
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM20155 ((2S)-5-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-3-...) Show SMILES COc1cccc([C@@H]2SC(=NN2C(=O)c2c(F)cc(F)cc2F)c2ccc(Cl)cc2)c1OC |r,c:9| Show InChI InChI=1S/C23H16ClF3N2O3S/c1-31-18-5-3-4-15(20(18)32-2)23-29(22(30)19-16(26)10-14(25)11-17(19)27)28-21(33-23)12-6-8-13(24)9-7-12/h3-11,23H,1-2H3/t23-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...				J Med Chem 50: 4255-9 (2007) Article DOI: 10.1021/jm070453f BindingDB Entry DOI: 10.7270/Q2BK19N6
					More data for this Ligand-Target Pair

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