BindingDB PrimarySearch

Found 16 hits Enz. Inhib. hit(s) with all data for entry = 50048824
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM82247 (8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	0.427	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description In vitro inhibition of rat liver dihydrofolate reductase.				J Med Chem 32: 2050-8 (1989) BindingDB Entry DOI: 10.7270/Q2RV0QXV
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50038349 ((S)-6-Chloro-2-methyl-1-phenyl-1,2,3,4-tetrahydro-...) Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	6.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description In vitro inhibition of rat liver dihydrofolate reductase.				J Med Chem 32: 2050-8 (1989) BindingDB Entry DOI: 10.7270/Q2RV0QXV
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50228322 (CHEMBL64117) Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]1Cc1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	27	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description In vitro inhibition of Escherichia coli dihydrofolate reductase.				J Med Chem 32: 2050-8 (1989) BindingDB Entry DOI: 10.7270/Q2RV0QXV
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50228321 (CHEMBL302393) Show SMILES CN1C[C@@H](c2ccccc2)c2cc(O)c(Cl)cc2C1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	87	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description In vitro inhibition of rat liver dihydrofolate reductase.				J Med Chem 32: 2050-8 (1989) BindingDB Entry DOI: 10.7270/Q2RV0QXV
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50367602 (CHEMBL65397) Show SMILES Oc1cc2[C@@H](NCCc2cc1Cl)c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	141	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description In vitro inhibition of rat liver dihydrofolate reductase.				J Med Chem 32: 2050-8 (1989) BindingDB Entry DOI: 10.7270/Q2RV0QXV
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50228322 (CHEMBL64117) Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]1Cc1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	145	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description In vitro inhibition of Escherichia coli dihydrofolate reductase.				J Med Chem 32: 2050-8 (1989) BindingDB Entry DOI: 10.7270/Q2RV0QXV
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50367601 (CHEMBL293828) Show SMILES CCCN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	178	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Antibacterial activity against Escherichia coli				J Med Chem 32: 2050-8 (1989) BindingDB Entry DOI: 10.7270/Q2RV0QXV
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50228321 (CHEMBL302393) Show SMILES CN1C[C@@H](c2ccccc2)c2cc(O)c(Cl)cc2C1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	263	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description In vitro inhibition of rat liver dihydrofolate reductase.				J Med Chem 32: 2050-8 (1989) BindingDB Entry DOI: 10.7270/Q2RV0QXV
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50228323 (CHEMBL59603) Show SMILES Oc1cc2[C@@H](CNCc2cc1Cl)c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	282	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description In vitro inhibition of Escherichia coli dihydrofolate reductase.				J Med Chem 32: 2050-8 (1989) BindingDB Entry DOI: 10.7270/Q2RV0QXV
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50038350 ((R)-6-Chloro-2-methyl-1-phenyl-1,2,3,4-tetrahydro-...) Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	447	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description In vitro inhibition of Escherichia coli dihydrofolate reductase.				J Med Chem 32: 2050-8 (1989) BindingDB Entry DOI: 10.7270/Q2RV0QXV
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM82247 (8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	891	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description In vitro inhibition of Escherichia coli dihydrofolate reductase.				J Med Chem 32: 2050-8 (1989) BindingDB Entry DOI: 10.7270/Q2RV0QXV
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50228323 (CHEMBL59603) Show SMILES Oc1cc2[C@@H](CNCc2cc1Cl)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.82E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description In vitro inhibition of rat liver dihydrofolate reductase.				J Med Chem 32: 2050-8 (1989) BindingDB Entry DOI: 10.7270/Q2RV0QXV
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50038349 ((S)-6-Chloro-2-methyl-1-phenyl-1,2,3,4-tetrahydro-...) Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.86E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Antibacterial activity against Escherichia coli				J Med Chem 32: 2050-8 (1989) BindingDB Entry DOI: 10.7270/Q2RV0QXV
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50367601 (CHEMBL293828) Show SMILES CCCN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.91E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description In vitro inhibition of dihydrofolate reductase of Escherichia coli				J Med Chem 32: 2050-8 (1989) BindingDB Entry DOI: 10.7270/Q2RV0QXV
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50367602 (CHEMBL65397) Show SMILES Oc1cc2[C@@H](NCCc2cc1Cl)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.72E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description In vitro inhibition of rat liver dihydrofolate reductase.				J Med Chem 32: 2050-8 (1989) BindingDB Entry DOI: 10.7270/Q2RV0QXV
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50038350 ((R)-6-Chloro-2-methyl-1-phenyl-1,2,3,4-tetrahydro-...) Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.91E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description In vitro inhibition of Escherichia coli dihydrofolate reductase.				J Med Chem 32: 2050-8 (1989) BindingDB Entry DOI: 10.7270/Q2RV0QXV
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair