Found 136 hits Enz. Inhib. hit(s) with all data for entry = 50016388 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50168389
(CHEMBL195218 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCCCS(C)(=O)=O)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C22H26F2N6O6S/c1-12(2)18-17(28-22(32)36-6-5-7-37(4,33)34)10-30-19(18)20(25-11-26-30)27-16-8-13(21(31)29-35-3)14(23)9-15(16)24/h8-12H,5-7H2,1-4H3,(H,28,32)(H,29,31)(H,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.0620 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human vascular endothelial growth factor receptor 2 (VEGFR-2) |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1/2/3/4
(Homo sapiens (Human)) | BDBM50168394
(2,4-Difluoro-5-[5-isopropyl-6-(5-isopropyl-[1,3,4]...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(C)C)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C22H23F2N7O3/c1-10(2)17-13(22-29-28-21(34-22)11(3)4)8-31-18(17)19(25-9-26-31)27-16-6-12(20(32)30-33-5)14(23)7-15(16)24/h6-11H,1-5H3,(H,30,32)(H,25,26,27) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1/2/3
(Homo sapiens (Human)) | BDBM50168397
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-oxazol-2-y...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4ncc(C)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C21H20F2N6O3/c1-10(2)17-13(21-24-7-11(3)32-21)8-29-18(17)19(25-9-26-29)27-16-5-12(20(30)28-31-4)14(22)6-15(16)23/h5-10H,1-4H3,(H,28,30)(H,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1/2/3
(Homo sapiens (Human)) | BDBM50168410
(5-[6-(5-Ethyl-[1,3,4]oxadiazol-2-yl)-5-isopropyl-p...)Show SMILES CCc1nnc(o1)-c1cn2ncnc(Nc3cc(C(=O)NOC)c(F)cc3F)c2c1C(C)C Show InChI InChI=1S/C21H21F2N7O3/c1-5-16-27-28-21(33-16)12-8-30-18(17(12)10(2)3)19(24-9-25-30)26-15-6-11(20(31)29-32-4)13(22)7-14(15)23/h6-10H,5H2,1-4H3,(H,29,31)(H,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1/2/3
(Homo sapiens (Human)) | BDBM50168398
(2,4-Difluoro-5-[5-isopropyl-6-(5-methanesulfonylme...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CS(C)(=O)=O)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C21H21F2N7O5S/c1-10(2)17-12(21-28-27-16(35-21)8-36(4,32)33)7-30-18(17)19(24-9-25-30)26-15-5-11(20(31)29-34-3)13(22)6-14(15)23/h5-7,9-10H,8H2,1-4H3,(H,29,31)(H,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1/2/3
(Homo sapiens (Human)) | BDBM50168390
(2,4-Difluoro-5-[6-(5-isobutyl-[1,3,4]oxadiazol-2-y...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC(C)C)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C23H25F2N7O3/c1-11(2)6-18-29-30-23(35-18)14-9-32-20(19(14)12(3)4)21(26-10-27-32)28-17-7-13(22(33)31-34-5)15(24)8-16(17)25/h7-12H,6H2,1-5H3,(H,31,33)(H,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1/2/3
(Homo sapiens (Human)) | BDBM50168391
(5-[6-(5-Cyclopropyl-[1,3,4]oxadiazol-2-yl)-5-isopr...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C4CC4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C22H21F2N7O3/c1-10(2)17-13(22-29-28-21(34-22)11-4-5-11)8-31-18(17)19(25-9-26-31)27-16-6-12(20(32)30-33-3)14(23)7-15(16)24/h6-11H,4-5H2,1-3H3,(H,30,32)(H,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1/2/3/4
(Homo sapiens (Human)) | BDBM50168397
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-oxazol-2-y...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4ncc(C)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C21H20F2N6O3/c1-10(2)17-13(21-24-7-11(3)32-21)8-29-18(17)19(25-9-26-29)27-16-5-12(20(30)28-31-4)14(22)6-15(16)23/h5-10H,1-4H3,(H,28,30)(H,25,26,27) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1/2/3
(Homo sapiens (Human)) | BDBM50168388
(5-[6-(5-Cyclopropylmethyl-[1,3,4]oxadiazol-2-yl)-5...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC5CC5)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C23H23F2N7O3/c1-11(2)19-14(23-30-29-18(35-23)6-12-4-5-12)9-32-20(19)21(26-10-27-32)28-17-7-13(22(33)31-34-3)15(24)8-16(17)25/h7-12H,4-6H2,1-3H3,(H,31,33)(H,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1/2/3/4
(Homo sapiens (Human)) | BDBM50168398
(2,4-Difluoro-5-[5-isopropyl-6-(5-methanesulfonylme...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CS(C)(=O)=O)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C21H21F2N7O5S/c1-10(2)17-12(21-28-27-16(35-21)8-36(4,32)33)7-30-18(17)19(24-9-25-30)26-15-5-11(20(31)29-34-3)13(22)6-14(15)23/h5-7,9-10H,8H2,1-4H3,(H,29,31)(H,24,25,26) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1/2/3/4
(Homo sapiens (Human)) | BDBM50168410
(5-[6-(5-Ethyl-[1,3,4]oxadiazol-2-yl)-5-isopropyl-p...)Show SMILES CCc1nnc(o1)-c1cn2ncnc(Nc3cc(C(=O)NOC)c(F)cc3F)c2c1C(C)C Show InChI InChI=1S/C21H21F2N7O3/c1-5-16-27-28-21(33-16)12-8-30-18(17(12)10(2)3)19(24-9-25-30)26-15-6-11(20(31)29-32-4)13(22)7-14(15)23/h6-10H,5H2,1-4H3,(H,29,31)(H,24,25,26) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1/2/3/4
(Homo sapiens (Human)) | BDBM50168391
(5-[6-(5-Cyclopropyl-[1,3,4]oxadiazol-2-yl)-5-isopr...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C4CC4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C22H21F2N7O3/c1-10(2)17-13(22-29-28-21(34-22)11-4-5-11)8-31-18(17)19(25-9-26-31)27-16-6-12(20(32)30-33-3)14(23)7-15(16)24/h6-11H,4-5H2,1-3H3,(H,30,32)(H,25,26,27) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1/2/3/4
(Homo sapiens (Human)) | BDBM50168387
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(C)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-27-26-10(3)32-20)7-29-17(16)18(23-8-24-29)25-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,25) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1/2/3/4
(Homo sapiens (Human)) | BDBM50168390
(2,4-Difluoro-5-[6-(5-isobutyl-[1,3,4]oxadiazol-2-y...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC(C)C)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C23H25F2N7O3/c1-11(2)6-18-29-30-23(35-18)14-9-32-20(19(14)12(3)4)21(26-10-27-32)28-17-7-13(22(33)31-34-5)15(24)8-16(17)25/h7-12H,6H2,1-5H3,(H,31,33)(H,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1/2/3
(Homo sapiens (Human)) | BDBM50168393
(5-[6-(5-Dimethylamino-[1,3,4]oxadiazol-2-yl)-5-iso...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)N(C)C)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C21H22F2N8O3/c1-10(2)16-12(20-27-28-21(34-20)30(3)4)8-31-17(16)18(24-9-25-31)26-15-6-11(19(32)29-33-5)13(22)7-14(15)23/h6-10H,1-5H3,(H,29,32)(H,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1/2/3
(Homo sapiens (Human)) | BDBM50168400
(2,4-Difluoro-5-[5-isopropyl-6-(3-methyl-[1,2,4]oxa...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nc(C)no4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-25-10(3)27-32-20)7-29-17(16)18(23-8-24-29)26-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1/2/3/4
(Homo sapiens (Human)) | BDBM50168393
(5-[6-(5-Dimethylamino-[1,3,4]oxadiazol-2-yl)-5-iso...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)N(C)C)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C21H22F2N8O3/c1-10(2)16-12(20-27-28-21(34-20)30(3)4)8-31-17(16)18(24-9-25-31)26-15-6-11(19(32)29-33-5)13(22)7-14(15)23/h6-10H,1-5H3,(H,29,32)(H,24,25,26) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1/2/3
(Homo sapiens (Human)) | BDBM50168387
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(C)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-27-26-10(3)32-20)7-29-17(16)18(23-8-24-29)25-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1/2/3/4
(Homo sapiens (Human)) | BDBM50168400
(2,4-Difluoro-5-[5-isopropyl-6-(3-methyl-[1,2,4]oxa...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nc(C)no4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-25-10(3)27-32-20)7-29-17(16)18(23-8-24-29)26-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,26) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50168397
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-oxazol-2-y...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4ncc(C)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C21H20F2N6O3/c1-10(2)17-13(21-24-7-11(3)32-21)8-29-18(17)19(25-9-26-29)27-16-5-12(20(30)28-31-4)14(22)6-15(16)23/h5-10H,1-4H3,(H,28,30)(H,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1) |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1/2/3/4
(Homo sapiens (Human)) | BDBM50168388
(5-[6-(5-Cyclopropylmethyl-[1,3,4]oxadiazol-2-yl)-5...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC5CC5)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C23H23F2N7O3/c1-11(2)19-14(23-30-29-18(35-23)6-12-4-5-12)9-32-20(19)21(26-10-27-32)28-17-7-13(22(33)31-34-3)15(24)8-16(17)25/h7-12H,4-6H2,1-3H3,(H,31,33)(H,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50168393
(5-[6-(5-Dimethylamino-[1,3,4]oxadiazol-2-yl)-5-iso...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)N(C)C)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C21H22F2N8O3/c1-10(2)16-12(20-27-28-21(34-20)30(3)4)8-31-17(16)18(24-9-25-31)26-15-6-11(19(32)29-33-5)13(22)7-14(15)23/h6-10H,1-5H3,(H,29,32)(H,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1) |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50168391
(5-[6-(5-Cyclopropyl-[1,3,4]oxadiazol-2-yl)-5-isopr...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C4CC4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C22H21F2N7O3/c1-10(2)17-13(22-29-28-21(34-22)11-4-5-11)8-31-18(17)19(25-9-26-31)27-16-6-12(20(32)30-33-3)14(23)7-15(16)24/h6-11H,4-5H2,1-3H3,(H,30,32)(H,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1) |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50168421
(4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5-...)Show SMILES CCOC(=O)c1cn2ncnc(Nc3cc(C(=O)NOC)c(F)cc3F)c2c1C(C)C Show InChI InChI=1S/C20H21F2N5O4/c1-5-31-20(29)12-8-27-17(16(12)10(2)3)18(23-9-24-27)25-15-6-11(19(28)26-30-4)13(21)7-14(15)22/h6-10H,5H2,1-4H3,(H,26,28)(H,23,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1) |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50168391
(5-[6-(5-Cyclopropyl-[1,3,4]oxadiazol-2-yl)-5-isopr...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C4CC4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C22H21F2N7O3/c1-10(2)17-13(22-29-28-21(34-22)11-4-5-11)8-31-18(17)19(25-9-26-31)27-16-6-12(20(32)30-33-3)14(23)7-15(16)24/h6-11H,4-5H2,1-3H3,(H,30,32)(H,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human fibroblast growth factor receptor 1 |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50168398
(2,4-Difluoro-5-[5-isopropyl-6-(5-methanesulfonylme...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CS(C)(=O)=O)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C21H21F2N7O5S/c1-10(2)17-12(21-28-27-16(35-21)8-36(4,32)33)7-30-18(17)19(24-9-25-30)26-15-5-11(20(31)29-34-3)13(22)6-14(15)23/h5-7,9-10H,8H2,1-4H3,(H,29,31)(H,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human fibroblast growth factor receptor 1 |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50168398
(2,4-Difluoro-5-[5-isopropyl-6-(5-methanesulfonylme...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CS(C)(=O)=O)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C21H21F2N7O5S/c1-10(2)17-12(21-28-27-16(35-21)8-36(4,32)33)7-30-18(17)19(24-9-25-30)26-15-5-11(20(31)29-34-3)13(22)6-14(15)23/h5-7,9-10H,8H2,1-4H3,(H,29,31)(H,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1) |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1/2/3
(Homo sapiens (Human)) | BDBM50168403
(5-[6-(5-Difluoromethyl-[1,3,4]oxadiazol-2-yl)-5-is...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)F)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C20H17F4N7O3/c1-8(2)14-10(19-28-29-20(34-19)16(23)24)6-31-15(14)17(25-7-26-31)27-13-4-9(18(32)30-33-3)11(21)5-12(13)22/h4-8,16H,1-3H3,(H,30,32)(H,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50168388
(5-[6-(5-Cyclopropylmethyl-[1,3,4]oxadiazol-2-yl)-5...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC5CC5)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C23H23F2N7O3/c1-11(2)19-14(23-30-29-18(35-23)6-12-4-5-12)9-32-20(19)21(26-10-27-32)28-17-7-13(22(33)31-34-3)15(24)8-16(17)25/h7-12H,4-6H2,1-3H3,(H,31,33)(H,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1) |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50168410
(5-[6-(5-Ethyl-[1,3,4]oxadiazol-2-yl)-5-isopropyl-p...)Show SMILES CCc1nnc(o1)-c1cn2ncnc(Nc3cc(C(=O)NOC)c(F)cc3F)c2c1C(C)C Show InChI InChI=1S/C21H21F2N7O3/c1-5-16-27-28-21(33-16)12-8-30-18(17(12)10(2)3)19(24-9-25-30)26-15-6-11(20(31)29-32-4)13(22)7-14(15)23/h6-10H,5H2,1-4H3,(H,29,31)(H,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1) |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1/2/3
(Homo sapiens (Human)) | BDBM50168394
(2,4-Difluoro-5-[5-isopropyl-6-(5-isopropyl-[1,3,4]...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(C)C)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C22H23F2N7O3/c1-10(2)17-13(22-29-28-21(34-22)11(3)4)8-31-18(17)19(25-9-26-31)27-16-6-12(20(32)30-33-5)14(23)7-15(16)24/h6-11H,1-5H3,(H,30,32)(H,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50168387
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(C)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-27-26-10(3)32-20)7-29-17(16)18(23-8-24-29)25-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1) |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50168393
(5-[6-(5-Dimethylamino-[1,3,4]oxadiazol-2-yl)-5-iso...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)N(C)C)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C21H22F2N8O3/c1-10(2)16-12(20-27-28-21(34-20)30(3)4)8-31-17(16)18(24-9-25-31)26-15-6-11(19(32)29-33-5)13(22)7-14(15)23/h6-10H,1-5H3,(H,29,32)(H,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human fibroblast growth factor receptor 1 |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1/2/3
(Homo sapiens (Human)) | BDBM50168420
(CHEMBL191594 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OC4CCN(C)CC4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C24H29F2N7O4/c1-13(2)20-19(30-24(35)37-14-5-7-32(3)8-6-14)11-33-21(20)22(27-12-28-33)29-18-9-15(23(34)31-36-4)16(25)10-17(18)26/h9-14H,5-8H2,1-4H3,(H,30,35)(H,31,34)(H,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50168387
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(C)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-27-26-10(3)32-20)7-29-17(16)18(23-8-24-29)25-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human fibroblast growth factor receptor 1 |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50168397
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-oxazol-2-y...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4ncc(C)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C21H20F2N6O3/c1-10(2)17-13(21-24-7-11(3)32-21)8-29-18(17)19(25-9-26-29)27-16-5-12(20(30)28-31-4)14(22)6-15(16)23/h5-10H,1-4H3,(H,28,30)(H,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human fibroblast growth factor receptor 1 |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1/2/3/4
(Homo sapiens (Human)) | BDBM50168403
(5-[6-(5-Difluoromethyl-[1,3,4]oxadiazol-2-yl)-5-is...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)F)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C20H17F4N7O3/c1-8(2)14-10(19-28-29-20(34-19)16(23)24)6-31-15(14)17(25-7-26-31)27-13-4-9(18(32)30-33-3)11(21)5-12(13)22/h4-8,16H,1-3H3,(H,30,32)(H,25,26,27) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50168394
(2,4-Difluoro-5-[5-isopropyl-6-(5-isopropyl-[1,3,4]...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(C)C)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C22H23F2N7O3/c1-10(2)17-13(22-29-28-21(34-22)11(3)4)8-31-18(17)19(25-9-26-31)27-16-6-12(20(32)30-33-5)14(23)7-15(16)24/h6-11H,1-5H3,(H,30,32)(H,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1) |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50168390
(2,4-Difluoro-5-[6-(5-isobutyl-[1,3,4]oxadiazol-2-y...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC(C)C)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C23H25F2N7O3/c1-11(2)6-18-29-30-23(35-18)14-9-32-20(19(14)12(3)4)21(26-10-27-32)28-17-7-13(22(33)31-34-5)15(24)8-16(17)25/h7-12H,6H2,1-5H3,(H,31,33)(H,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1) |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1/2/3
(Homo sapiens (Human)) | BDBM50168395
(2,4-Difluoro-5-{5-isopropyl-6-[5-(2,2,2-trifluoro-...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC(F)(F)F)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C21H18F5N7O3/c1-9(2)16-11(20-31-30-15(36-20)6-21(24,25)26)7-33-17(16)18(27-8-28-33)29-14-4-10(19(34)32-35-3)12(22)5-13(14)23/h4-5,7-9H,6H2,1-3H3,(H,32,34)(H,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50168388
(5-[6-(5-Cyclopropylmethyl-[1,3,4]oxadiazol-2-yl)-5...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC5CC5)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C23H23F2N7O3/c1-11(2)19-14(23-30-29-18(35-23)6-12-4-5-12)9-32-20(19)21(26-10-27-32)28-17-7-13(22(33)31-34-3)15(24)8-16(17)25/h7-12H,4-6H2,1-3H3,(H,31,33)(H,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human fibroblast growth factor receptor 1 |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1/2/3
(Homo sapiens (Human)) | BDBM50168402
(5-{6-[5-(Difluoro-methanesulfonyl-methyl)-[1,3,4]o...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)(F)S(C)(=O)=O)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C21H19F4N7O5S/c1-9(2)15-11(19-29-30-20(37-19)21(24,25)38(4,34)35)7-32-16(15)17(26-8-27-32)28-14-5-10(18(33)31-36-3)12(22)6-13(14)23/h5-9H,1-4H3,(H,31,33)(H,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50168410
(5-[6-(5-Ethyl-[1,3,4]oxadiazol-2-yl)-5-isopropyl-p...)Show SMILES CCc1nnc(o1)-c1cn2ncnc(Nc3cc(C(=O)NOC)c(F)cc3F)c2c1C(C)C Show InChI InChI=1S/C21H21F2N7O3/c1-5-16-27-28-21(33-16)12-8-30-18(17(12)10(2)3)19(24-9-25-30)26-15-6-11(20(31)29-32-4)13(22)7-14(15)23/h6-10H,5H2,1-4H3,(H,29,31)(H,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human fibroblast growth factor receptor 1 |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50168395
(2,4-Difluoro-5-{5-isopropyl-6-[5-(2,2,2-trifluoro-...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC(F)(F)F)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C21H18F5N7O3/c1-9(2)16-11(20-31-30-15(36-20)6-21(24,25)26)7-33-17(16)18(27-8-28-33)29-14-4-10(19(34)32-35-3)12(22)5-13(14)23/h4-5,7-9H,6H2,1-3H3,(H,32,34)(H,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1) |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1/2/3
(Homo sapiens (Human)) | BDBM50168399
(CHEMBL366019 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)Show SMILES CCOC(=O)Nc1cn2ncnc(Nc3cc(C(=O)NOC)c(F)cc3F)c2c1C(C)C Show InChI InChI=1S/C20H22F2N6O4/c1-5-32-20(30)26-15-8-28-17(16(15)10(2)3)18(23-9-24-28)25-14-6-11(19(29)27-31-4)12(21)7-13(14)22/h6-10H,5H2,1-4H3,(H,26,30)(H,27,29)(H,23,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1/2/3/4
(Homo sapiens (Human)) | BDBM50168407
(2,4-Difluoro-5-[5-isopropyl-6-(5-trifluoromethyl-[...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)(F)F)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C20H16F5N7O3/c1-8(2)14-10(18-29-30-19(35-18)20(23,24)25)6-32-15(14)16(26-7-27-32)28-13-4-9(17(33)31-34-3)11(21)5-12(13)22/h4-8H,1-3H3,(H,31,33)(H,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50168390
(2,4-Difluoro-5-[6-(5-isobutyl-[1,3,4]oxadiazol-2-y...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC(C)C)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C23H25F2N7O3/c1-11(2)6-18-29-30-23(35-18)14-9-32-20(19(14)12(3)4)21(26-10-27-32)28-17-7-13(22(33)31-34-5)15(24)8-16(17)25/h7-12H,6H2,1-5H3,(H,31,33)(H,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human fibroblast growth factor receptor 1 |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50168411
(4-(2-Fluoro-5-methoxycarbamoyl-phenylamino)-5-isop...)Show SMILES CCOC(=O)c1cn2ncnc(Nc3cc(ccc3F)C(=O)NOC)c2c1C(C)C Show InChI InChI=1S/C20H22FN5O4/c1-5-30-20(28)13-9-26-17(16(13)11(2)3)18(22-10-23-26)24-15-8-12(6-7-14(15)21)19(27)25-29-4/h6-11H,5H2,1-4H3,(H,25,27)(H,22,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1) |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1/2/3
(Homo sapiens (Human)) | BDBM50168407
(2,4-Difluoro-5-[5-isopropyl-6-(5-trifluoromethyl-[...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)(F)F)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C20H16F5N7O3/c1-8(2)14-10(18-29-30-19(35-18)20(23,24)25)6-32-15(14)16(26-7-27-32)28-13-4-9(17(33)31-34-3)11(21)5-12(13)22/h4-8H,1-3H3,(H,31,33)(H,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50168420
(CHEMBL191594 | [4-(2,4-Difluoro-5-methoxycarbamoyl...)Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OC4CCN(C)CC4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C24H29F2N7O4/c1-13(2)20-19(30-24(35)37-14-5-7-32(3)8-6-14)11-33-21(20)22(27-12-28-33)29-18-9-15(23(34)31-36-4)16(25)10-17(18)26/h9-14H,5-8H2,1-4H3,(H,30,35)(H,31,34)(H,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1) |
J Med Chem 48: 3991-4008 (2005)
Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN |
More data for this Ligand-Target Pair | |