Found 34 hits Enz. Inhib. hit(s) with all data for entry = 50047258 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384121
(CHEMBL2029678)Show SMILES COCCOc1cnc2ccc(cc2c1)[C@H](C)n1nnc2ccn(-c3cc(C)ns3)c(=O)c12 |r| Show InChI InChI=1S/C23H22N6O3S/c1-14-10-21(33-26-14)28-7-6-20-22(23(28)30)29(27-25-20)15(2)16-4-5-19-17(11-16)12-18(13-24-19)32-9-8-31-3/h4-7,10-13,15H,8-9H2,1-3H3/t15-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f... |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384121
(CHEMBL2029678)Show SMILES COCCOc1cnc2ccc(cc2c1)[C@H](C)n1nnc2ccn(-c3cc(C)ns3)c(=O)c12 |r| Show InChI InChI=1S/C23H22N6O3S/c1-14-10-21(33-26-14)28-7-6-20-22(23(28)30)29(27-25-20)15(2)16-4-5-19-17(11-16)12-18(13-24-19)32-9-8-31-3/h4-7,10-13,15H,8-9H2,1-3H3/t15-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f... |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50157535
(CHEMBL3787004)Show SMILES COc1cnc2ccn([C@H](C)c3nnc4c(F)cc(cn34)-c3cnn(C)c3)c(=O)c2c1 |r| Show InChI InChI=1S/C21H18FN7O2/c1-12(28-5-4-18-16(21(28)30)7-15(31-3)9-23-18)19-25-26-20-17(22)6-13(11-29(19)20)14-8-24-27(2)10-14/h4-12H,1-3H3/t12-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f... |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50157612
(CHEMBL3785909)Show SMILES COCCOc1cnc2ccn([C@H](C)c3nnc4c(F)cc(cn34)-c3cnn(C)c3)c(=O)c2c1 |r| Show InChI InChI=1S/C23H22FN7O3/c1-14(30-5-4-20-18(23(30)32)9-17(11-25-20)34-7-6-33-3)21-27-28-22-19(24)8-15(13-31(21)22)16-10-26-29(2)12-16/h4-5,8-14H,6-7H2,1-3H3/t14-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f... |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50156350
(CHEMBL3785199)Show SMILES COCCOc1cnc2ccn([C@H](C)c3nnc4c(F)cc(cn34)-c3cc(C)no3)c(=O)c2c1 |r| Show InChI InChI=1S/C23H21FN6O4/c1-13-8-20(34-28-13)15-9-18(24)22-27-26-21(30(22)12-15)14(2)29-5-4-19-17(23(29)31)10-16(11-25-19)33-7-6-32-3/h4-5,8-12,14H,6-7H2,1-3H3/t14-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f... |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50156350
(CHEMBL3785199)Show SMILES COCCOc1cnc2ccn([C@H](C)c3nnc4c(F)cc(cn34)-c3cc(C)no3)c(=O)c2c1 |r| Show InChI InChI=1S/C23H21FN6O4/c1-13-8-20(34-28-13)15-9-18(24)22-27-26-21(30(22)12-15)14(2)29-5-4-19-17(23(29)31)10-16(11-25-19)33-7-6-32-3/h4-5,8-12,14H,6-7H2,1-3H3/t14-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f... |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50078374
(CHEMBL3414926)Show SMILES COCCOc1cnc2ccc(cc2c1)[C@H](C)c1nnc2c(F)cc(cn12)-c1cc(C)no1 |r| Show InChI InChI=1S/C24H22FN5O3/c1-14-8-22(33-29-14)18-11-20(25)24-28-27-23(30(24)13-18)15(2)16-4-5-21-17(9-16)10-19(12-26-21)32-7-6-31-3/h4-5,8-13,15H,6-7H2,1-3H3/t15-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f... |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50156349
(CHEMBL3786314)Show SMILES COc1cnc2ccn([C@H](C)c3nnc4c(F)cc(cn34)-c3cc(C)no3)c(=O)c2c1 |r| Show InChI InChI=1S/C21H17FN6O3/c1-11-6-18(31-26-11)13-7-16(22)20-25-24-19(28(20)10-13)12(2)27-5-4-17-15(21(27)29)8-14(30-3)9-23-17/h4-10,12H,1-3H3/t12-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f... |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50156349
(CHEMBL3786314)Show SMILES COc1cnc2ccn([C@H](C)c3nnc4c(F)cc(cn34)-c3cc(C)no3)c(=O)c2c1 |r| Show InChI InChI=1S/C21H17FN6O3/c1-11-6-18(31-26-11)13-7-16(22)20-25-24-19(28(20)10-13)12(2)27-5-4-17-15(21(27)29)8-14(30-3)9-23-17/h4-10,12H,1-3H3/t12-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f... |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50157609
(CHEMBL3785094)Show SMILES COCCOc1cnc2ccn([C@H](C)c3nnc4ccc(cn34)-c3cc(C)no3)c(=O)c2c1 |r| Show InChI InChI=1S/C23H22N6O4/c1-14-10-20(33-27-14)16-4-5-21-25-26-22(29(21)13-16)15(2)28-7-6-19-18(23(28)30)11-17(12-24-19)32-9-8-31-3/h4-7,10-13,15H,8-9H2,1-3H3/t15-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f... |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50157610
(CHEMBL3787109)Show SMILES C[C@H](c1nnc2c(F)cc(cn12)-c1cnn(C)c1)n1ccc2ncccc2c1=O |r| Show InChI InChI=1S/C20H16FN7O/c1-12(27-7-5-17-15(20(27)29)4-3-6-22-17)18-24-25-19-16(21)8-13(11-28(18)19)14-9-23-26(2)10-14/h3-12H,1-2H3/t12-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f... |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50156348
(CHEMBL3786495)Show SMILES C[C@H](c1nnc2c(F)cc(cn12)-c1cc(C)no1)n1ccc2ncccc2c1=O |r| Show InChI InChI=1S/C20H15FN6O2/c1-11-8-17(29-25-11)13-9-15(21)19-24-23-18(27(19)10-13)12(2)26-7-5-16-14(20(26)28)4-3-6-22-16/h3-10,12H,1-2H3/t12-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f... |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50157537
(CHEMBL3786005)Show SMILES COCCOc1cnc2ccn([C@H](C)c3nnc4ccc(cn34)-c3cnn(C)c3)c(=O)c2c1 |r| Show InChI InChI=1S/C23H23N7O3/c1-15(22-27-26-21-5-4-16(14-30(21)22)17-11-25-28(2)13-17)29-7-6-20-19(23(29)31)10-18(12-24-20)33-9-8-32-3/h4-7,10-15H,8-9H2,1-3H3/t15-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f... |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50156348
(CHEMBL3786495)Show SMILES C[C@H](c1nnc2c(F)cc(cn12)-c1cc(C)no1)n1ccc2ncccc2c1=O |r| Show InChI InChI=1S/C20H15FN6O2/c1-11-8-17(29-25-11)13-9-15(21)19-24-23-18(27(19)10-13)12(2)26-7-5-16-14(20(26)28)4-3-6-22-16/h3-10,12H,1-2H3/t12-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f... |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM24476
(7-methoxy-4-{[6-(3,4,5-trifluorophenyl)-[1,2,4]tri...)Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3cc(F)c(F)c(F)c3)ccnc2c1 Show InChI InChI=1S/C22H14F3N5O2/c1-31-13-2-3-14-18(10-13)26-7-6-19(14)32-11-21-28-27-20-5-4-17(29-30(20)21)12-8-15(23)22(25)16(24)9-12/h2-10H,11H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f... |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50157612
(CHEMBL3785909)Show SMILES COCCOc1cnc2ccn([C@H](C)c3nnc4c(F)cc(cn34)-c3cnn(C)c3)c(=O)c2c1 |r| Show InChI InChI=1S/C23H22FN7O3/c1-14(30-5-4-20-18(23(30)32)9-17(11-25-20)34-7-6-33-3)21-27-28-22-19(24)8-15(13-31(21)22)16-10-26-29(2)12-16/h4-5,8-14H,6-7H2,1-3H3/t14-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
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Similars
| PDB
Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of HGF-mediated MET autophosphorylation in human PC3 cells preincubated for 1 hr followed by stimulation with human HGF measured after 10 ... |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50078374
(CHEMBL3414926)Show SMILES COCCOc1cnc2ccc(cc2c1)[C@H](C)c1nnc2c(F)cc(cn12)-c1cc(C)no1 |r| Show InChI InChI=1S/C24H22FN5O3/c1-14-8-22(33-29-14)18-11-20(25)24-28-27-23(30(24)13-18)15(2)16-4-5-21-17(9-16)10-19(12-26-21)32-7-6-31-3/h4-5,8-13,15H,6-7H2,1-3H3/t15-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of HGF-mediated MET autophosphorylation in human PC3 cells preincubated for 1 hr followed by stimulation with human HGF measured after 10 ... |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50302905
(7-methoxy-N-((6-(3-methylisothiazol-5-yl)-[1,2,4]t...)Show SMILES COc1cnc2c(NCc3nnc4ccc(nn34)-c3cc(C)ns3)ccnc2c1 Show InChI InChI=1S/C19H16N8OS/c1-11-7-16(29-26-11)13-3-4-17-23-24-18(27(17)25-13)10-21-14-5-6-20-15-8-12(28-2)9-22-19(14)15/h3-9H,10H2,1-2H3,(H,20,21) | PDB
MMDB
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UniProtKB/SwissProt
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DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f... |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50302905
(7-methoxy-N-((6-(3-methylisothiazol-5-yl)-[1,2,4]t...)Show SMILES COc1cnc2c(NCc3nnc4ccc(nn34)-c3cc(C)ns3)ccnc2c1 Show InChI InChI=1S/C19H16N8OS/c1-11-7-16(29-26-11)13-3-4-17-23-24-18(27(17)25-13)10-21-14-5-6-20-15-8-12(28-2)9-22-19(14)15/h3-9H,10H2,1-2H3,(H,20,21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f... |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50157535
(CHEMBL3787004)Show SMILES COc1cnc2ccn([C@H](C)c3nnc4c(F)cc(cn34)-c3cnn(C)c3)c(=O)c2c1 |r| Show InChI InChI=1S/C21H18FN7O2/c1-12(28-5-4-18-16(21(28)30)7-15(31-3)9-23-18)19-25-26-20-17(22)6-13(11-29(19)20)14-8-24-27(2)10-14/h4-12H,1-3H3/t12-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of HGF-mediated MET autophosphorylation in human PC3 cells preincubated for 1 hr followed by stimulation with human HGF measured after 10 ... |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50157609
(CHEMBL3785094)Show SMILES COCCOc1cnc2ccn([C@H](C)c3nnc4ccc(cn34)-c3cc(C)no3)c(=O)c2c1 |r| Show InChI InChI=1S/C23H22N6O4/c1-14-10-20(33-27-14)16-4-5-21-25-26-22(29(21)13-16)15(2)28-7-6-19-18(23(28)30)11-17(12-24-19)32-9-8-31-3/h4-7,10-13,15H,8-9H2,1-3H3/t15-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of HGF-mediated MET autophosphorylation in human PC3 cells preincubated for 1 hr followed by stimulation with human HGF measured after 10 ... |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM24476
(7-methoxy-4-{[6-(3,4,5-trifluorophenyl)-[1,2,4]tri...)Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3cc(F)c(F)c(F)c3)ccnc2c1 Show InChI InChI=1S/C22H14F3N5O2/c1-31-13-2-3-14-18(10-13)26-7-6-19(14)32-11-21-28-27-20-5-4-17(29-30(20)21)12-8-15(23)22(25)16(24)9-12/h2-10H,11H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of HGF-mediated MET autophosphorylation in human PC3 cells preincubated for 1 hr followed by stimulation with human HGF measured after 10 ... |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50157610
(CHEMBL3787109)Show SMILES C[C@H](c1nnc2c(F)cc(cn12)-c1cnn(C)c1)n1ccc2ncccc2c1=O |r| Show InChI InChI=1S/C20H16FN7O/c1-12(27-7-5-17-15(20(27)29)4-3-6-22-17)18-24-25-19-16(21)8-13(11-28(18)19)14-9-23-26(2)10-14/h3-12H,1-2H3/t12-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of HGF-mediated MET autophosphorylation in human PC3 cells preincubated for 1 hr followed by stimulation with human HGF measured after 10 ... |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50157537
(CHEMBL3786005)Show SMILES COCCOc1cnc2ccn([C@H](C)c3nnc4ccc(cn34)-c3cnn(C)c3)c(=O)c2c1 |r| Show InChI InChI=1S/C23H23N7O3/c1-15(22-27-26-21-5-4-16(14-30(21)22)17-11-25-28(2)13-17)29-7-6-20-19(23(29)31)10-18(12-24-20)33-9-8-32-3/h4-7,10-15H,8-9H2,1-3H3/t15-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of HGF-mediated MET autophosphorylation in human PC3 cells preincubated for 1 hr followed by stimulation with human HGF measured after 10 ... |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50157536
(CHEMBL3785374)Show SMILES COc1cnc2ccn([C@H](C)c3nnc4ccc(cn34)-c3cnn(C)c3)c(=O)c2c1 |r| Show InChI InChI=1S/C21H19N7O2/c1-13(27-7-6-18-17(21(27)29)8-16(30-3)10-22-18)20-25-24-19-5-4-14(12-28(19)20)15-9-23-26(2)11-15/h4-13H,1-3H3/t13-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f... |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50157536
(CHEMBL3785374)Show SMILES COc1cnc2ccn([C@H](C)c3nnc4ccc(cn34)-c3cnn(C)c3)c(=O)c2c1 |r| Show InChI InChI=1S/C21H19N7O2/c1-13(27-7-6-18-17(21(27)29)8-16(30-3)10-22-18)20-25-24-19-5-4-14(12-28(19)20)15-9-23-26(2)11-15/h4-13H,1-3H3/t13-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of HGF-mediated MET autophosphorylation in human PC3 cells preincubated for 1 hr followed by stimulation with human HGF measured after 10 ... |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50384121
(CHEMBL2029678)Show SMILES COCCOc1cnc2ccc(cc2c1)[C@H](C)n1nnc2ccn(-c3cc(C)ns3)c(=O)c12 |r| Show InChI InChI=1S/C23H22N6O3S/c1-14-10-21(33-26-14)28-7-6-20-22(23(28)30)29(27-25-20)15(2)16-4-5-19-17(11-16)12-18(13-24-19)32-9-8-31-3/h4-7,10-13,15H,8-9H2,1-3H3/t15-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of CYP3A4 (unknown origin) in absence of NADPH |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM24476
(7-methoxy-4-{[6-(3,4,5-trifluorophenyl)-[1,2,4]tri...)Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3cc(F)c(F)c(F)c3)ccnc2c1 Show InChI InChI=1S/C22H14F3N5O2/c1-31-13-2-3-14-18(10-13)26-7-6-19(14)32-11-21-28-27-20-5-4-17(29-30(20)21)12-8-15(23)22(25)16(24)9-12/h2-10H,11H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of CYP3A4 (unknown origin) in absence of NADPH |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50384121
(CHEMBL2029678)Show SMILES COCCOc1cnc2ccc(cc2c1)[C@H](C)n1nnc2ccn(-c3cc(C)ns3)c(=O)c12 |r| Show InChI InChI=1S/C23H22N6O3S/c1-14-10-21(33-26-14)28-7-6-20-22(23(28)30)29(27-25-20)15(2)16-4-5-19-17(11-16)12-18(13-24-19)32-9-8-31-3/h4-7,10-13,15H,8-9H2,1-3H3/t15-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of CYP3A4 (unknown origin) in presence of NADPH |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50302905
(7-methoxy-N-((6-(3-methylisothiazol-5-yl)-[1,2,4]t...)Show SMILES COc1cnc2c(NCc3nnc4ccc(nn34)-c3cc(C)ns3)ccnc2c1 Show InChI InChI=1S/C19H16N8OS/c1-11-7-16(29-26-11)13-3-4-17-23-24-18(27(17)25-13)10-21-14-5-6-20-15-8-12(28-2)9-22-19(14)15/h3-9H,10H2,1-2H3,(H,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of CYP3A4 (unknown origin) in absence of NADPH |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM24476
(7-methoxy-4-{[6-(3,4,5-trifluorophenyl)-[1,2,4]tri...)Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3cc(F)c(F)c(F)c3)ccnc2c1 Show InChI InChI=1S/C22H14F3N5O2/c1-31-13-2-3-14-18(10-13)26-7-6-19(14)32-11-21-28-27-20-5-4-17(29-30(20)21)12-8-15(23)22(25)16(24)9-12/h2-10H,11H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of CYP3A4 (unknown origin) in presence of NADPH |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50302905
(7-methoxy-N-((6-(3-methylisothiazol-5-yl)-[1,2,4]t...)Show SMILES COc1cnc2c(NCc3nnc4ccc(nn34)-c3cc(C)ns3)ccnc2c1 Show InChI InChI=1S/C19H16N8OS/c1-11-7-16(29-26-11)13-3-4-17-23-24-18(27(17)25-13)10-21-14-5-6-20-15-8-12(28-2)9-22-19(14)15/h3-9H,10H2,1-2H3,(H,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of CYP3A4 (unknown origin) in absence of NADPH |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50078374
(CHEMBL3414926)Show SMILES COCCOc1cnc2ccc(cc2c1)[C@H](C)c1nnc2c(F)cc(cn12)-c1cc(C)no1 |r| Show InChI InChI=1S/C24H22FN5O3/c1-14-8-22(33-29-14)18-11-20(25)24-28-27-23(30(24)13-18)15(2)16-4-5-21-17(9-16)10-19(12-26-21)32-7-6-31-3/h4-5,8-13,15H,6-7H2,1-3H3/t15-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of CYP3A4 (unknown origin) in absence of NADPH |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50078374
(CHEMBL3414926)Show SMILES COCCOc1cnc2ccc(cc2c1)[C@H](C)c1nnc2c(F)cc(cn12)-c1cc(C)no1 |r| Show InChI InChI=1S/C24H22FN5O3/c1-14-8-22(33-29-14)18-11-20(25)24-28-27-23(30(24)13-18)15(2)16-4-5-21-17(9-16)10-19(12-26-21)32-7-6-31-3/h4-5,8-13,15H,6-7H2,1-3H3/t15-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description
Inhibition of CYP3A4 (unknown origin) in presence of NADPH |
J Med Chem 59: 2328-42 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN |
More data for this
Ligand-Target Pair | |
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