Found 40 hits Enz. Inhib. hit(s) with all data for entry = 50048108 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Proto-oncogene tyrosine-protein kinase ROS
(Homo sapiens (Human)) | BDBM50204615
(CHEMBL3921664)Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(N\N=C\c2ccc(F)cc2)ncc1Cl Show InChI InChI=1S/C20H19ClFN5O2S/c1-13(2)30(28,29)18-6-4-3-5-17(18)25-19-16(21)12-23-20(26-19)27-24-11-14-7-9-15(22)10-8-14/h3-13H,1-2H3,(H2,23,25,26,27)/b24-11+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of ROS1 (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase ROS
(Homo sapiens (Human)) | BDBM50436850
(CERITINIB | CHEMBL2403108 | LDK378 | US10053458, C...)Show SMILES CC(C)Oc1cc(C2CCNCC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 Show InChI InChI=1S/C28H36ClN5O3S/c1-17(2)37-25-15-21(20-10-12-30-13-11-20)19(5)14-24(25)33-28-31-16-22(29)27(34-28)32-23-8-6-7-9-26(23)38(35,36)18(3)4/h6-9,14-18,20,30H,10-13H2,1-5H3,(H2,31,32,33,34) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of ROS1 (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
ALK tyrosine kinase receptor
(Homo sapiens (Human)) | BDBM50204615
(CHEMBL3921664)Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(N\N=C\c2ccc(F)cc2)ncc1Cl Show InChI InChI=1S/C20H19ClFN5O2S/c1-13(2)30(28,29)18-6-4-3-5-17(18)25-19-16(21)12-23-20(26-19)27-24-11-14-7-9-15(22)10-8-14/h3-13H,1-2H3,(H2,23,25,26,27)/b24-11+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of ALK (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
ALK tyrosine kinase receptor
(Homo sapiens (Human)) | BDBM50436850
(CERITINIB | CHEMBL2403108 | LDK378 | US10053458, C...)Show SMILES CC(C)Oc1cc(C2CCNCC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 Show InChI InChI=1S/C28H36ClN5O3S/c1-17(2)37-25-15-21(20-10-12-30-13-11-20)19(5)14-24(25)33-28-31-16-22(29)27(34-28)32-23-8-6-7-9-26(23)38(35,36)18(3)4/h6-9,14-18,20,30H,10-13H2,1-5H3,(H2,31,32,33,34) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of ALK (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Proto-oncogene tyrosine-protein kinase ROS
(Homo sapiens (Human)) | BDBM50204639
(CHEMBL3894726)Show SMILES COc1ccc(\C=N\Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)cc1 Show InChI InChI=1S/C21H22ClN5O3S/c1-14(2)31(28,29)19-7-5-4-6-18(19)25-20-17(22)13-23-21(26-20)27-24-12-15-8-10-16(30-3)11-9-15/h4-14H,1-3H3,(H2,23,25,26,27)/b24-12+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of ROS1 (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306682
((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl |r| Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of c-Met (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
ALK tyrosine kinase receptor
(Homo sapiens (Human)) | BDBM50204616
(CHEMBL3922762)Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(N\N=C(/C)c2ccc(F)cc2)ncc1Cl Show InChI InChI=1S/C21H21ClFN5O2S/c1-13(2)31(29,30)19-7-5-4-6-18(19)25-20-17(22)12-24-21(26-20)28-27-14(3)15-8-10-16(23)11-9-15/h4-13H,1-3H3,(H2,24,25,26,28)/b27-14+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of ALK (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase ROS
(Homo sapiens (Human)) | BDBM50204616
(CHEMBL3922762)Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(N\N=C(/C)c2ccc(F)cc2)ncc1Cl Show InChI InChI=1S/C21H21ClFN5O2S/c1-13(2)31(29,30)19-7-5-4-6-18(19)25-20-17(22)12-24-21(26-20)28-27-14(3)15-8-10-16(23)11-9-15/h4-13H,1-3H3,(H2,24,25,26,28)/b27-14+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of ROS1 (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase ROS
(Homo sapiens (Human)) | BDBM50204619
(CHEMBL3893810)Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(N\N=C\c2ccc(cc2)C(F)(F)F)ncc1Cl Show InChI InChI=1S/C21H19ClF3N5O2S/c1-13(2)33(31,32)18-6-4-3-5-17(18)28-19-16(22)12-26-20(29-19)30-27-11-14-7-9-15(10-8-14)21(23,24)25/h3-13H,1-2H3,(H2,26,28,29,30)/b27-11+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of ROS1 (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
ALK tyrosine kinase receptor
(Homo sapiens (Human)) | BDBM50204619
(CHEMBL3893810)Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(N\N=C\c2ccc(cc2)C(F)(F)F)ncc1Cl Show InChI InChI=1S/C21H19ClF3N5O2S/c1-13(2)33(31,32)18-6-4-3-5-17(18)28-19-16(22)12-26-20(29-19)30-27-11-14-7-9-15(10-8-14)21(23,24)25/h3-13H,1-2H3,(H2,26,28,29,30)/b27-11+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of ALK (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase ROS
(Homo sapiens (Human)) | BDBM50204620
(CHEMBL3950479)Show SMILES COc1ccc(cc1)C(\C)=N\Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 Show InChI InChI=1S/C22H24ClN5O3S/c1-14(2)32(29,30)20-8-6-5-7-19(20)25-21-18(23)13-24-22(26-21)28-27-15(3)16-9-11-17(31-4)12-10-16/h5-14H,1-4H3,(H2,24,25,26,28)/b27-15+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of ROS1 (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
ALK tyrosine kinase receptor
(Homo sapiens (Human)) | BDBM50204639
(CHEMBL3894726)Show SMILES COc1ccc(\C=N\Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)cc1 Show InChI InChI=1S/C21H22ClN5O3S/c1-14(2)31(28,29)19-7-5-4-6-18(19)25-20-17(22)13-23-21(26-20)27-24-12-15-8-10-16(30-3)11-9-15/h4-14H,1-3H3,(H2,23,25,26,27)/b24-12+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of ALK (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
ALK tyrosine kinase receptor
(Homo sapiens (Human)) | BDBM50204620
(CHEMBL3950479)Show SMILES COc1ccc(cc1)C(\C)=N\Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 Show InChI InChI=1S/C22H24ClN5O3S/c1-14(2)32(29,30)20-8-6-5-7-19(20)25-21-18(23)13-24-22(26-21)28-27-15(3)16-9-11-17(31-4)12-10-16/h5-14H,1-4H3,(H2,24,25,26,28)/b27-15+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of ALK (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase ROS
(Homo sapiens (Human)) | BDBM50204618
(CHEMBL3934594)Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(N\N=C\c2cccc(c2)C(F)(F)F)ncc1Cl Show InChI InChI=1S/C21H19ClF3N5O2S/c1-13(2)33(31,32)18-9-4-3-8-17(18)28-19-16(22)12-26-20(29-19)30-27-11-14-6-5-7-15(10-14)21(23,24)25/h3-13H,1-2H3,(H2,26,28,29,30)/b27-11+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of ROS1 (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
ALK tyrosine kinase receptor
(Homo sapiens (Human)) | BDBM50204618
(CHEMBL3934594)Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(N\N=C\c2cccc(c2)C(F)(F)F)ncc1Cl Show InChI InChI=1S/C21H19ClF3N5O2S/c1-13(2)33(31,32)18-9-4-3-8-17(18)28-19-16(22)12-26-20(29-19)30-27-11-14-6-5-7-15(10-14)21(23,24)25/h3-13H,1-2H3,(H2,26,28,29,30)/b27-11+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of ALK (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase ROS
(Homo sapiens (Human)) | BDBM50204614
(CHEMBL3913728)Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(N\N=C\c2ccc(OC(F)(F)F)cc2)ncc1Cl Show InChI InChI=1S/C21H19ClF3N5O3S/c1-13(2)34(31,32)18-6-4-3-5-17(18)28-19-16(22)12-26-20(29-19)30-27-11-14-7-9-15(10-8-14)33-21(23,24)25/h3-13H,1-2H3,(H2,26,28,29,30)/b27-11+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of ROS1 (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
ALK tyrosine kinase receptor
(Homo sapiens (Human)) | BDBM50204614
(CHEMBL3913728)Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(N\N=C\c2ccc(OC(F)(F)F)cc2)ncc1Cl Show InChI InChI=1S/C21H19ClF3N5O3S/c1-13(2)34(31,32)18-6-4-3-5-17(18)28-19-16(22)12-26-20(29-19)30-27-11-14-7-9-15(10-8-14)33-21(23,24)25/h3-13H,1-2H3,(H2,26,28,29,30)/b27-11+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of ALK (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase ROS
(Homo sapiens (Human)) | BDBM50204617
(CHEMBL3905284)Show SMILES COc1cccc(\C=N\Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c1 Show InChI InChI=1S/C21H22ClN5O3S/c1-14(2)31(28,29)19-10-5-4-9-18(19)25-20-17(22)13-23-21(26-20)27-24-12-15-7-6-8-16(11-15)30-3/h4-14H,1-3H3,(H2,23,25,26,27)/b24-12+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of ROS1 (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
ALK tyrosine kinase receptor
(Homo sapiens (Human)) | BDBM50204617
(CHEMBL3905284)Show SMILES COc1cccc(\C=N\Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c1 Show InChI InChI=1S/C21H22ClN5O3S/c1-14(2)31(28,29)19-10-5-4-9-18(19)25-20-17(22)13-23-21(26-20)27-24-12-15-7-6-8-16(11-15)30-3/h4-14H,1-3H3,(H2,23,25,26,27)/b24-12+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of ALK (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase ROS
(Homo sapiens (Human)) | BDBM50306682
((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl |r| Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of ROS1 (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
ALK tyrosine kinase receptor
(Homo sapiens (Human)) | BDBM50306682
((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl |r| Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of ALK (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50204639
(CHEMBL3894726)Show SMILES COc1ccc(\C=N\Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)cc1 Show InChI InChI=1S/C21H22ClN5O3S/c1-14(2)31(28,29)19-7-5-4-6-18(19)25-20-17(22)13-23-21(26-20)27-24-12-15-8-10-16(30-3)11-9-15/h4-14H,1-3H3,(H2,23,25,26,27)/b24-12+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 157 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of c-Met (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50204615
(CHEMBL3921664)Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(N\N=C\c2ccc(F)cc2)ncc1Cl Show InChI InChI=1S/C20H19ClFN5O2S/c1-13(2)30(28,29)18-6-4-3-5-17(18)25-19-16(21)12-23-20(26-19)27-24-11-14-7-9-15(22)10-8-14/h3-13H,1-2H3,(H2,23,25,26,27)/b24-11+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of c-Met (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50204617
(CHEMBL3905284)Show SMILES COc1cccc(\C=N\Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c1 Show InChI InChI=1S/C21H22ClN5O3S/c1-14(2)31(28,29)19-10-5-4-9-18(19)25-20-17(22)13-23-21(26-20)27-24-12-15-7-6-8-16(11-15)30-3/h4-14H,1-3H3,(H2,23,25,26,27)/b24-12+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 376 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of c-Met (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50204619
(CHEMBL3893810)Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(N\N=C\c2ccc(cc2)C(F)(F)F)ncc1Cl Show InChI InChI=1S/C21H19ClF3N5O2S/c1-13(2)33(31,32)18-6-4-3-5-17(18)28-19-16(22)12-26-20(29-19)30-27-11-14-7-9-15(10-8-14)21(23,24)25/h3-13H,1-2H3,(H2,26,28,29,30)/b27-11+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of c-Met (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50204614
(CHEMBL3913728)Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(N\N=C\c2ccc(OC(F)(F)F)cc2)ncc1Cl Show InChI InChI=1S/C21H19ClF3N5O3S/c1-13(2)34(31,32)18-6-4-3-5-17(18)28-19-16(22)12-26-20(29-19)30-27-11-14-7-9-15(10-8-14)33-21(23,24)25/h3-13H,1-2H3,(H2,26,28,29,30)/b27-11+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 393 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of c-Met (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50204618
(CHEMBL3934594)Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(N\N=C\c2cccc(c2)C(F)(F)F)ncc1Cl Show InChI InChI=1S/C21H19ClF3N5O2S/c1-13(2)33(31,32)18-9-4-3-8-17(18)28-19-16(22)12-26-20(29-19)30-27-11-14-6-5-7-15(10-14)21(23,24)25/h3-13H,1-2H3,(H2,26,28,29,30)/b27-11+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50204618
(CHEMBL3934594)Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(N\N=C\c2cccc(c2)C(F)(F)F)ncc1Cl Show InChI InChI=1S/C21H19ClF3N5O2S/c1-13(2)33(31,32)18-9-4-3-8-17(18)28-19-16(22)12-26-20(29-19)30-27-11-14-6-5-7-15(10-14)21(23,24)25/h3-13H,1-2H3,(H2,26,28,29,30)/b27-11+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 479 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of c-Met (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50204615
(CHEMBL3921664)Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(N\N=C\c2ccc(F)cc2)ncc1Cl Show InChI InChI=1S/C20H19ClFN5O2S/c1-13(2)30(28,29)18-6-4-3-5-17(18)25-19-16(21)12-23-20(26-19)27-24-11-14-7-9-15(22)10-8-14/h3-13H,1-2H3,(H2,23,25,26,27)/b24-11+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 570 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50204639
(CHEMBL3894726)Show SMILES COc1ccc(\C=N\Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)cc1 Show InChI InChI=1S/C21H22ClN5O3S/c1-14(2)31(28,29)19-7-5-4-6-18(19)25-20-17(22)13-23-21(26-20)27-24-12-15-8-10-16(30-3)11-9-15/h4-14H,1-3H3,(H2,23,25,26,27)/b24-12+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 587 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50204619
(CHEMBL3893810)Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(N\N=C\c2ccc(cc2)C(F)(F)F)ncc1Cl Show InChI InChI=1S/C21H19ClF3N5O2S/c1-13(2)33(31,32)18-6-4-3-5-17(18)28-19-16(22)12-26-20(29-19)30-27-11-14-7-9-15(10-8-14)21(23,24)25/h3-13H,1-2H3,(H2,26,28,29,30)/b27-11+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 593 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50204617
(CHEMBL3905284)Show SMILES COc1cccc(\C=N\Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c1 Show InChI InChI=1S/C21H22ClN5O3S/c1-14(2)31(28,29)19-10-5-4-9-18(19)25-20-17(22)13-23-21(26-20)27-24-12-15-7-6-8-16(11-15)30-3/h4-14H,1-3H3,(H2,23,25,26,27)/b24-12+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 601 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50204614
(CHEMBL3913728)Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(N\N=C\c2ccc(OC(F)(F)F)cc2)ncc1Cl Show InChI InChI=1S/C21H19ClF3N5O3S/c1-13(2)34(31,32)18-6-4-3-5-17(18)28-19-16(22)12-26-20(29-19)30-27-11-14-7-9-15(10-8-14)33-21(23,24)25/h3-13H,1-2H3,(H2,26,28,29,30)/b27-11+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 898 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50436850
(CERITINIB | CHEMBL2403108 | LDK378 | US10053458, C...)Show SMILES CC(C)Oc1cc(C2CCNCC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 Show InChI InChI=1S/C28H36ClN5O3S/c1-17(2)37-25-15-21(20-10-12-30-13-11-20)19(5)14-24(25)33-28-31-16-22(29)27(34-28)32-23-8-6-7-9-26(23)38(35,36)18(3)4/h6-9,14-18,20,30H,10-13H2,1-5H3,(H2,31,32,33,34) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of c-Met (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50306682
((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl |r| Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50204620
(CHEMBL3950479)Show SMILES COc1ccc(cc1)C(\C)=N\Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 Show InChI InChI=1S/C22H24ClN5O3S/c1-14(2)32(29,30)20-8-6-5-7-19(20)25-21-18(23)13-24-22(26-21)28-27-15(3)16-9-11-17(31-4)12-10-16/h5-14H,1-4H3,(H2,24,25,26,28)/b27-15+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50204616
(CHEMBL3922762)Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(N\N=C(/C)c2ccc(F)cc2)ncc1Cl Show InChI InChI=1S/C21H21ClFN5O2S/c1-13(2)31(29,30)19-7-5-4-6-18(19)25-20-17(22)12-24-21(26-20)28-27-14(3)15-8-10-16(23)11-9-15/h4-13H,1-3H3,(H2,24,25,26,28)/b27-14+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50204616
(CHEMBL3922762)Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(N\N=C(/C)c2ccc(F)cc2)ncc1Cl Show InChI InChI=1S/C21H21ClFN5O2S/c1-13(2)31(29,30)19-7-5-4-6-18(19)25-20-17(22)12-24-21(26-20)28-27-14(3)15-8-10-16(23)11-9-15/h4-13H,1-3H3,(H2,24,25,26,28)/b27-14+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of c-Met (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50436850
(CERITINIB | CHEMBL2403108 | LDK378 | US10053458, C...)Show SMILES CC(C)Oc1cc(C2CCNCC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 Show InChI InChI=1S/C28H36ClN5O3S/c1-17(2)37-25-15-21(20-10-12-30-13-11-20)19(5)14-24(25)33-28-31-16-22(29)27(34-28)32-23-8-6-7-9-26(23)38(35,36)18(3)4/h6-9,14-18,20,30H,10-13H2,1-5H3,(H2,31,32,33,34) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50204620
(CHEMBL3950479)Show SMILES COc1ccc(cc1)C(\C)=N\Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 Show InChI InChI=1S/C22H24ClN5O3S/c1-14(2)32(29,30)20-8-6-5-7-19(20)25-21-18(23)13-24-22(26-21)28-27-15(3)16-9-11-17(31-4)12-10-16/h5-14H,1-4H3,(H2,24,25,26,28)/b27-15+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of c-Met (unknown origin) using peptide as substrate after 60 mins by HTRF assay |
Eur J Med Chem 123: 80-89 (2016)
Article DOI: 10.1016/j.ejmech.2016.06.056 BindingDB Entry DOI: 10.7270/Q2MK6FVX |
More data for this Ligand-Target Pair | |