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Compile Data Set for Download or QSAR

Found 36 hits Enz. Inhib. hit(s) with all data for entry = 50031808   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neuronal acetylcholine receptor subunit alpha-7


(Rattus norvegicus (Rat))		BDBM50319673
PNG
(1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-...)
Show SMILES Fc1ccc(cc1)-c1ccc(NC(=O)NCCCCN2CCCCC2)cn1
Show InChI InChI=1S/C21H27FN4O/c22-18-8-6-17(7-9-18)20-11-10-19(16-24-20)25-21(27)23-12-2-5-15-26-13-3-1-4-14-26/h6-11,16H,1-5,12-15H2,(H2,23,25,27)
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 44n/an/an/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from rat alpha7 nAChR expressed in rat GH4C1 cells

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(Homo sapiens (Human))		BDBM50319673
PNG
(1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-...)
Show SMILES Fc1ccc(cc1)-c1ccc(NC(=O)NCCCCN2CCCCC2)cn1
Show InChI InChI=1S/C21H27FN4O/c22-18-8-6-17(7-9-18)20-11-10-19(16-24-20)25-21(27)23-12-2-5-15-26-13-3-1-4-14-26/h6-11,16H,1-5,12-15H2,(H2,23,25,27)
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 6.00E+3n/an/an/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Binding affinity to 5HT4 receptor

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50319673
PNG
(1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-...)
Show SMILES Fc1ccc(cc1)-c1ccc(NC(=O)NCCCCN2CCCCC2)cn1
Show InChI InChI=1S/C21H27FN4O/c22-18-8-6-17(7-9-18)20-11-10-19(16-24-20)25-21(27)23-12-2-5-15-26-13-3-1-4-14-26/h6-11,16H,1-5,12-15H2,(H2,23,25,27)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Binding affinity to human ERG expressed in CHO cells

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM50319676
PNG
(1-(2'-fluorobiphenyl-4-yl)-3-(4-(piperidin-1-yl)bu...)
Show SMILES Fc1ccccc1-c1ccc(NC(=O)NCCCCN2CCCCC2)cc1
Show InChI InChI=1S/C22H28FN3O/c23-21-9-3-2-8-20(21)18-10-12-19(13-11-18)25-22(27)24-14-4-7-17-26-15-5-1-6-16-26/h2-3,8-13H,1,4-7,14-17H2,(H2,24,25,27)
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n/an/a 5.70E+3n/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Agonist activity at human 5HT3A receptor expressed in HEK293 cells by FLIPR assay

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM50319677
PNG
(1-(4'-fluorobiphenyl-4-yl)-3-(4-(piperidin-1-yl)bu...)
Show SMILES Fc1ccc(cc1)-c1ccc(NC(=O)NCCCCN2CCCCC2)cc1
Show InChI InChI=1S/C22H28FN3O/c23-20-10-6-18(7-11-20)19-8-12-21(13-9-19)25-22(27)24-14-2-5-17-26-15-3-1-4-16-26/h6-13H,1-5,14-17H2,(H2,24,25,27)
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n/an/a 5.80E+3n/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Agonist activity at human 5HT3A receptor expressed in HEK293 cells by FLIPR assay

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))		BDBM50319673
PNG
(1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-...)
Show SMILES Fc1ccc(cc1)-c1ccc(NC(=O)NCCCCN2CCCCC2)cn1
Show InChI InChI=1S/C21H27FN4O/c22-18-8-6-17(7-9-18)20-11-10-19(16-24-20)25-21(27)23-12-2-5-15-26-13-3-1-4-14-26/h6-11,16H,1-5,12-15H2,(H2,23,25,27)
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n/an/a 7.50E+3n/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Binding affinity to adrenergic alpha2B receptor

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM50319675
PNG
(1-(2'-methoxybiphenyl-4-yl)-3-(4-(piperidin-1-yl)b...)
Show SMILES COc1ccccc1-c1ccc(NC(=O)NCCCCN2CCCCC2)cc1
Show InChI InChI=1S/C23H31N3O2/c1-28-22-10-4-3-9-21(22)19-11-13-20(14-12-19)25-23(27)24-15-5-8-18-26-16-6-2-7-17-26/h3-4,9-14H,2,5-8,15-18H2,1H3,(H2,24,25,27)
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n/an/a 7.80E+3n/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Agonist activity at human 5HT3A receptor expressed in HEK293 cells by FLIPR assay

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM50319674
PNG
(1-(biphenyl-4-yl)-3-(4-(piperidin-1-yl)butyl)urea ...)
Show SMILES O=C(NCCCCN1CCCCC1)Nc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C22H29N3O/c26-22(23-15-5-8-18-25-16-6-2-7-17-25)24-21-13-11-20(12-14-21)19-9-3-1-4-10-19/h1,3-4,9-14H,2,5-8,15-18H2,(H2,23,24,26)
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n/an/a 7.90E+3n/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Agonist activity at human 5HT3A receptor expressed in HEK293 cells by FLIPR assay

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2


(Homo sapiens (Human))		BDBM50319673
PNG
(1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-...)
Show SMILES Fc1ccc(cc1)-c1ccc(NC(=O)NCCCCN2CCCCC2)cn1
Show InChI InChI=1S/C21H27FN4O/c22-18-8-6-17(7-9-18)20-11-10-19(16-24-20)25-21(27)23-12-2-5-15-26-13-3-1-4-14-26/h6-11,16H,1-5,12-15H2,(H2,23,25,27)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nAChR

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM50319683
PNG
(1-(6'-fluoro-2,3'-bipyridin-5-yl)-3-(4-(piperidin-...)
Show SMILES Fc1ccc(cn1)-c1ccc(NC(=O)NCCCCN2CCCCC2)cn1
Show InChI InChI=1S/C20H26FN5O/c21-19-9-6-16(14-24-19)18-8-7-17(15-23-18)25-20(27)22-10-2-5-13-26-11-3-1-4-12-26/h6-9,14-15H,1-5,10-13H2,(H2,22,25,27)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Agonist activity at human 5HT3A receptor expressed in HEK293 cells by FLIPR assay

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM50319684
PNG
(1-(2,2'-bipyridin-5-yl)-3-(4-(piperidin-1-yl)butyl...)
Show SMILES O=C(NCCCCN1CCCCC1)Nc1ccc(nc1)-c1ccccn1
Show InChI InChI=1S/C20H27N5O/c26-20(22-12-4-7-15-25-13-5-1-6-14-25)24-17-9-10-19(23-16-17)18-8-2-3-11-21-18/h2-3,8-11,16H,1,4-7,12-15H2,(H2,22,24,26)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Agonist activity at human 5HT3A receptor expressed in HEK293 cells by FLIPR assay

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM50319673
PNG
(1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-...)
Show SMILES Fc1ccc(cc1)-c1ccc(NC(=O)NCCCCN2CCCCC2)cn1
Show InChI InChI=1S/C21H27FN4O/c22-18-8-6-17(7-9-18)20-11-10-19(16-24-20)25-21(27)23-12-2-5-15-26-13-3-1-4-14-26/h6-11,16H,1-5,12-15H2,(H2,23,25,27)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Agonist activity at human 5HT3A receptor expressed in HEK293 cells by FLIPR assay

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM50319682
PNG
(1-(6-(2-fluorophenyl)pyridin-3-yl)-3-(4-(piperidin...)
Show SMILES Fc1ccccc1-c1ccc(NC(=O)NCCCCN2CCCCC2)cn1
Show InChI InChI=1S/C21H27FN4O/c22-19-9-3-2-8-18(19)20-11-10-17(16-24-20)25-21(27)23-12-4-7-15-26-13-5-1-6-14-26/h2-3,8-11,16H,1,4-7,12-15H2,(H2,23,25,27)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Agonist activity at human 5HT3A receptor expressed in HEK293 cells by FLIPR assay

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM50319681
PNG
(1-(6-(2-methoxyphenyl)pyridin-3-yl)-3-(4-(piperidi...)
Show SMILES COc1ccccc1-c1ccc(NC(=O)NCCCCN2CCCCC2)cn1
Show InChI InChI=1S/C22H30N4O2/c1-28-21-10-4-3-9-19(21)20-12-11-18(17-24-20)25-22(27)23-13-5-8-16-26-14-6-2-7-15-26/h3-4,9-12,17H,2,5-8,13-16H2,1H3,(H2,23,25,27)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Agonist activity at human 5HT3A receptor expressed in HEK293 cells by FLIPR assay

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM50319680
PNG
(1-(6-phenylpyridin-3-yl)-3-(4-(piperidin-1-yl)buty...)
Show SMILES O=C(NCCCCN1CCCCC1)Nc1ccc(nc1)-c1ccccc1
Show InChI InChI=1S/C21H28N4O/c26-21(22-13-5-8-16-25-14-6-2-7-15-25)24-19-11-12-20(23-17-19)18-9-3-1-4-10-18/h1,3-4,9-12,17H,2,5-8,13-16H2,(H2,22,24,26)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Agonist activity at human 5HT3A receptor expressed in HEK293 cells by FLIPR assay

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM50319679
PNG
(1-(4-Piperidin-1-ylbutyl)-3-(4-pyridin-2-ylphenyl)...)
Show SMILES O=C(NCCCCN1CCCCC1)Nc1ccc(cc1)-c1ccccn1
Show InChI InChI=1S/C21H28N4O/c26-21(23-14-4-7-17-25-15-5-1-6-16-25)24-19-11-9-18(10-12-19)20-8-2-3-13-22-20/h2-3,8-13H,1,4-7,14-17H2,(H2,23,24,26)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Agonist activity at human 5HT3A receptor expressed in HEK293 cells by FLIPR assay

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM50319678
PNG
(1-(4-(6-fluoropyridin-3-yl)phenyl)-3-(4-(piperidin...)
Show SMILES Fc1ccc(cn1)-c1ccc(NC(=O)NCCCCN2CCCCC2)cc1
Show InChI InChI=1S/C21H27FN4O/c22-20-11-8-18(16-24-20)17-6-9-19(10-7-17)25-21(27)23-12-2-5-15-26-13-3-1-4-14-26/h6-11,16H,1-5,12-15H2,(H2,23,25,27)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Agonist activity at human 5HT3A receptor expressed in HEK293 cells by FLIPR assay

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50319673
PNG
(1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-...)
Show SMILES Fc1ccc(cc1)-c1ccc(NC(=O)NCCCCN2CCCCC2)cn1
Show InChI InChI=1S/C21H27FN4O/c22-18-8-6-17(7-9-18)20-11-10-19(16-24-20)25-21(27)23-12-2-5-15-26-13-3-1-4-14-26/h6-11,16H,1-5,12-15H2,(H2,23,25,27)
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n/an/a 3.50E+4n/an/an/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Binding affinity to adrenergic alpha2A receptor

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Rattus norvegicus (Rat))		BDBM50319672
PNG
(1-(4-(Morpholin-4-yl)butyl)-3-(4-pyridin-3-ylpheny...)
Show SMILES O=C(NCCCCN1CCOCC1)Nc1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C20H26N4O2/c25-20(22-10-1-2-11-24-12-14-26-15-13-24)23-19-7-5-17(6-8-19)18-4-3-9-21-16-18/h3-9,16H,1-2,10-15H2,(H2,22,23,25)
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n/an/an/an/a 490n/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from rat alpha7 nAChR expressed in rat GH4C1 cells

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Rattus norvegicus (Rat))		BDBM50319681
PNG
(1-(6-(2-methoxyphenyl)pyridin-3-yl)-3-(4-(piperidi...)
Show SMILES COc1ccccc1-c1ccc(NC(=O)NCCCCN2CCCCC2)cn1
Show InChI InChI=1S/C22H30N4O2/c1-28-21-10-4-3-9-19(21)20-12-11-18(17-24-20)25-22(27)23-13-5-8-16-26-14-6-2-7-15-26/h3-4,9-12,17H,2,5-8,13-16H2,1H3,(H2,23,25,27)
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n/an/an/an/a 230n/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from rat alpha7 nAChR expressed in rat GH4C1 cells

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Rattus norvegicus (Rat))		BDBM50319682
PNG
(1-(6-(2-fluorophenyl)pyridin-3-yl)-3-(4-(piperidin...)
Show SMILES Fc1ccccc1-c1ccc(NC(=O)NCCCCN2CCCCC2)cn1
Show InChI InChI=1S/C21H27FN4O/c22-19-9-3-2-8-18(19)20-11-10-17(16-24-20)25-21(27)23-12-4-7-15-26-13-5-1-6-14-26/h2-3,8-11,16H,1,4-7,12-15H2,(H2,23,25,27)
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n/an/an/an/a 150n/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from rat alpha7 nAChR expressed in rat GH4C1 cells

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Rattus norvegicus (Rat))		BDBM50319673
PNG
(1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-...)
Show SMILES Fc1ccc(cc1)-c1ccc(NC(=O)NCCCCN2CCCCC2)cn1
Show InChI InChI=1S/C21H27FN4O/c22-18-8-6-17(7-9-18)20-11-10-19(16-24-20)25-21(27)23-12-2-5-15-26-13-3-1-4-14-26/h6-11,16H,1-5,12-15H2,(H2,23,25,27)
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n/an/an/an/a 70n/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from rat alpha7 nAChR expressed in rat GH4C1 cells

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Rattus norvegicus (Rat))		BDBM50319683
PNG
(1-(6'-fluoro-2,3'-bipyridin-5-yl)-3-(4-(piperidin-...)
Show SMILES Fc1ccc(cn1)-c1ccc(NC(=O)NCCCCN2CCCCC2)cn1
Show InChI InChI=1S/C20H26FN5O/c21-19-9-6-16(14-24-19)18-8-7-17(15-23-18)25-20(27)22-10-2-5-13-26-11-3-1-4-12-26/h6-9,14-15H,1-5,10-13H2,(H2,22,25,27)
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n/an/an/an/a 530n/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from rat alpha7 nAChR expressed in rat GH4C1 cells

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Rattus norvegicus (Rat))		BDBM50319684
PNG
(1-(2,2'-bipyridin-5-yl)-3-(4-(piperidin-1-yl)butyl...)
Show SMILES O=C(NCCCCN1CCCCC1)Nc1ccc(nc1)-c1ccccn1
Show InChI InChI=1S/C20H27N5O/c26-20(22-12-4-7-15-25-13-5-1-6-14-25)24-17-9-10-19(23-16-17)18-8-2-3-11-21-18/h2-3,8-11,16H,1,4-7,12-15H2,(H2,22,24,26)
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n/an/an/an/a 390n/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from rat alpha7 nAChR expressed in rat GH4C1 cells

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Rattus norvegicus (Rat))		BDBM50319670
PNG
(6-Piperidin-1-ylhexanoic acid(4-pyridin-3-yl-pheny...)
Show SMILES O=C(CCCCCN1CCCCC1)Nc1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C22H29N3O/c26-22(9-3-1-4-15-25-16-5-2-6-17-25)24-21-12-10-19(11-13-21)20-8-7-14-23-18-20/h7-8,10-14,18H,1-6,9,15-17H2,(H,24,26)
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n/an/an/an/a 890n/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from rat alpha7 nAChR expressed in rat GH4C1 cells

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Rattus norvegicus (Rat))		BDBM50300803
PNG
(5-(piperidin-1-yl)-N-(4-(pyridin-3-yl)phenyl)penta...)
Show SMILES O=C(CCCCN1CCCCC1)Nc1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C21H27N3O/c25-21(8-2-5-16-24-14-3-1-4-15-24)23-20-11-9-18(10-12-20)19-7-6-13-22-17-19/h6-7,9-13,17H,1-5,8,14-16H2,(H,23,25)
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n/an/an/an/a 350n/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from rat alpha7 nAChR expressed in rat GH4C1 cells

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Rattus norvegicus (Rat))		BDBM50300802
PNG
(5-Morpholin-4-ylpentanoic acid(4-pyridin-3-ylpheny...)
Show SMILES O=C(CCCCN1CCOCC1)Nc1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C20H25N3O2/c24-20(5-1-2-11-23-12-14-25-15-13-23)22-19-8-6-17(7-9-19)18-4-3-10-21-16-18/h3-4,6-10,16H,1-2,5,11-15H2,(H,22,24)
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n/an/an/an/a 1.65E+3n/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from rat alpha7 nAChR expressed in rat GH4C1 cells

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Rattus norvegicus (Rat))		BDBM50319673
PNG
(1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-...)
Show SMILES Fc1ccc(cc1)-c1ccc(NC(=O)NCCCCN2CCCCC2)cn1
Show InChI InChI=1S/C21H27FN4O/c22-18-8-6-17(7-9-18)20-11-10-19(16-24-20)25-21(27)23-12-2-5-15-26-13-3-1-4-14-26/h6-11,16H,1-5,12-15H2,(H2,23,25,27)
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n/an/an/an/a 490n/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Agonist activity at rat rat alpha7 nAChR expressed in rat GH4C1 cells by whole cell patch-clamp electrophysiology

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Rattus norvegicus (Rat))		BDBM50319678
PNG
(1-(4-(6-fluoropyridin-3-yl)phenyl)-3-(4-(piperidin...)
Show SMILES Fc1ccc(cn1)-c1ccc(NC(=O)NCCCCN2CCCCC2)cc1
Show InChI InChI=1S/C21H27FN4O/c22-20-11-8-18(16-24-20)17-6-9-19(10-7-17)25-21(27)23-12-2-5-15-26-13-3-1-4-14-26/h6-11,16H,1-5,12-15H2,(H2,23,25,27)
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n/an/an/an/a 120n/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from rat alpha7 nAChR expressed in rat GH4C1 cells

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Rattus norvegicus (Rat))		BDBM50319677
PNG
(1-(4'-fluorobiphenyl-4-yl)-3-(4-(piperidin-1-yl)bu...)
Show SMILES Fc1ccc(cc1)-c1ccc(NC(=O)NCCCCN2CCCCC2)cc1
Show InChI InChI=1S/C22H28FN3O/c23-20-10-6-18(7-11-20)19-8-12-21(13-9-19)25-22(27)24-14-2-5-17-26-15-3-1-4-16-26/h6-13H,1-5,14-17H2,(H2,24,25,27)
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n/an/an/an/a 220n/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from rat alpha7 nAChR expressed in rat GH4C1 cells

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Rattus norvegicus (Rat))		BDBM50319676
PNG
(1-(2'-fluorobiphenyl-4-yl)-3-(4-(piperidin-1-yl)bu...)
Show SMILES Fc1ccccc1-c1ccc(NC(=O)NCCCCN2CCCCC2)cc1
Show InChI InChI=1S/C22H28FN3O/c23-21-9-3-2-8-20(21)18-10-12-19(13-11-18)25-22(27)24-14-4-7-17-26-15-5-1-6-16-26/h2-3,8-13H,1,4-7,14-17H2,(H2,24,25,27)
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n/an/an/an/a 130n/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from rat alpha7 nAChR expressed in rat GH4C1 cells

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Rattus norvegicus (Rat))		BDBM50319675
PNG
(1-(2'-methoxybiphenyl-4-yl)-3-(4-(piperidin-1-yl)b...)
Show SMILES COc1ccccc1-c1ccc(NC(=O)NCCCCN2CCCCC2)cc1
Show InChI InChI=1S/C23H31N3O2/c1-28-22-10-4-3-9-21(22)19-11-13-20(14-12-19)25-23(27)24-15-5-8-18-26-16-6-2-7-17-26/h3-4,9-14H,2,5-8,15-18H2,1H3,(H2,24,25,27)
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n/an/an/an/a 140n/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from rat alpha7 nAChR expressed in rat GH4C1 cells

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Rattus norvegicus (Rat))		BDBM50319674
PNG
(1-(biphenyl-4-yl)-3-(4-(piperidin-1-yl)butyl)urea ...)
Show SMILES O=C(NCCCCN1CCCCC1)Nc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C22H29N3O/c26-22(23-15-5-8-18-25-16-6-2-7-17-25)24-21-13-11-20(12-14-21)19-9-3-1-4-10-19/h1,3-4,9-14H,2,5-8,15-18H2,(H2,23,24,26)
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n/an/an/an/a 260n/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from rat alpha7 nAChR expressed in rat GH4C1 cells

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Rattus norvegicus (Rat))		BDBM50319671
PNG
(1-(4-Piperidin-1-yl)butyl-3-(4-pyridin-3-ylphenyl)...)
Show SMILES O=C(NCCCCN1CCCCC1)Nc1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C21H28N4O/c26-21(23-13-2-5-16-25-14-3-1-4-15-25)24-20-10-8-18(9-11-20)19-7-6-12-22-17-19/h6-12,17H,1-5,13-16H2,(H2,23,24,26)
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n/an/an/an/a 120n/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from rat alpha7 nAChR expressed in rat GH4C1 cells

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Rattus norvegicus (Rat))		BDBM50319679
PNG
(1-(4-Piperidin-1-ylbutyl)-3-(4-pyridin-2-ylphenyl)...)
Show SMILES O=C(NCCCCN1CCCCC1)Nc1ccc(cc1)-c1ccccn1
Show InChI InChI=1S/C21H28N4O/c26-21(23-14-4-7-17-25-15-5-1-6-16-25)24-19-11-9-18(10-12-19)20-8-2-3-13-22-20/h2-3,8-13H,1,4-7,14-17H2,(H2,23,24,26)
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n/an/an/an/a 130n/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from rat alpha7 nAChR expressed in rat GH4C1 cells

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Rattus norvegicus (Rat))		BDBM50319680
PNG
(1-(6-phenylpyridin-3-yl)-3-(4-(piperidin-1-yl)buty...)
Show SMILES O=C(NCCCCN1CCCCC1)Nc1ccc(nc1)-c1ccccc1
Show InChI InChI=1S/C21H28N4O/c26-21(22-13-5-8-16-25-14-6-2-7-15-25)24-19-11-12-20(23-17-19)18-9-3-1-4-10-18/h1,3-4,9-12,17H,2,5-8,13-16H2,(H2,22,24,26)
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n/an/an/an/a 120n/an/an/an/a



Siena Biotech SpA

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from rat alpha7 nAChR expressed in rat GH4C1 cells

J Med Chem 53: 4379-89 (2010)


Article DOI: 10.1021/jm901692q
BindingDB Entry DOI: 10.7270/Q2S46S4Q
More data for this
Ligand-Target Pair