Found 40 hits Enz. Inhib. hit(s) with all data for entry = 50033850 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352565
(CHEMBL1825149)Show SMILES Cc1ccc(cc1-c1ccc2c(NC(=O)C22CCSCC2)c1)C(=O)NC1CC1 Show InChI InChI=1S/C23H24N2O2S/c1-14-2-3-16(21(26)24-17-5-6-17)12-18(14)15-4-7-19-20(13-15)25-22(27)23(19)8-10-28-11-9-23/h2-4,7,12-13,17H,5-6,8-11H2,1H3,(H,24,26)(H,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human p38alpha using biotinylated ATF2 substrate by FRET assay |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352566
(CHEMBL1825148 | US8772288, 23)Show SMILES Cc1ccc(cc1-c1ccc2c(NC(=O)C22CCOCC2)c1)C(=O)Nc1ccon1 Show InChI InChI=1S/C23H21N3O4/c1-14-2-3-16(21(27)25-20-6-9-30-26-20)12-17(14)15-4-5-18-19(13-15)24-22(28)23(18)7-10-29-11-8-23/h2-6,9,12-13H,7-8,10-11H2,1H3,(H,24,28)(H,25,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human p38alpha using biotinylated ATF2 substrate by FRET assay |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352572
(CHEMBL1825157 | US8772288, 51)Show SMILES Cc1ccc(cc1-c1cc2NC(=O)C3(CCCC3)c2cn1)C(=O)NC1CC1 Show InChI InChI=1S/C22H23N3O2/c1-13-4-5-14(20(26)24-15-6-7-15)10-16(13)18-11-19-17(12-23-18)22(21(27)25-19)8-2-3-9-22/h4-5,10-12,15H,2-3,6-9H2,1H3,(H,24,26)(H,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human p38alpha using biotinylated ATF2 substrate by FRET assay |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352570
(CHEMBL1825154)Show SMILES Cc1ccc(cc1-c1ccc2c(NC(=O)C22CCC(F)(F)CC2)c1)C(=O)Nc1ccon1 Show InChI InChI=1S/C24H21F2N3O3/c1-14-2-3-16(21(30)28-20-6-11-32-29-20)12-17(14)15-4-5-18-19(13-15)27-22(31)23(18)7-9-24(25,26)10-8-23/h2-6,11-13H,7-10H2,1H3,(H,27,31)(H,28,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human p38alpha using biotinylated ATF2 substrate by FRET assay |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352569
(CHEMBL1825146 | US8772288, 31)Show SMILES Cc1c(F)cc(cc1-c1ccc2c(NC(=O)C22CCN(CC2)S(C)(=O)=O)c1)C(=O)NC1CC1 Show InChI InChI=1S/C24H26FN3O4S/c1-14-18(11-16(12-20(14)25)22(29)26-17-4-5-17)15-3-6-19-21(13-15)27-23(30)24(19)7-9-28(10-8-24)33(2,31)32/h3,6,11-13,17H,4-5,7-10H2,1-2H3,(H,26,29)(H,27,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human p38alpha using biotinylated ATF2 substrate by FRET assay |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352568
(CHEMBL1825151)Show SMILES Cc1ccc(cc1-c1ccc2c(NC(=O)[C@@]22CC[C@H](O)CC2)c1)C(=O)NC1CC1 |r,wD:15.15,18.20,(-4.28,-16.05,;-2.94,-16.81,;-1.62,-16.03,;-.27,-16.8,;-.27,-18.34,;-1.6,-19.11,;-2.94,-18.35,;-4.26,-19.12,;-4.26,-20.67,;-5.59,-21.44,;-6.93,-20.67,;-6.92,-19.13,;-8.39,-18.65,;-9.29,-19.9,;-10.83,-19.89,;-8.39,-21.14,;-7.3,-22.23,;-7.71,-23.72,;-9.2,-24.12,;-9.6,-25.6,;-10.29,-23.02,;-9.89,-21.54,;-5.6,-18.35,;1.07,-19.11,;1.07,-20.65,;2.4,-18.33,;3.73,-19.1,;4.51,-20.43,;5.28,-19.09,)| Show InChI InChI=1S/C24H26N2O3/c1-14-2-3-16(22(28)25-17-5-6-17)12-19(14)15-4-7-20-21(13-15)26-23(29)24(20)10-8-18(27)9-11-24/h2-4,7,12-13,17-18,27H,5-6,8-11H2,1H3,(H,25,28)(H,26,29)/t18-,24+ | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human p38alpha using biotinylated ATF2 substrate by FRET assay |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352571
(CHEMBL1825152)Show SMILES Cc1ccc(cc1-c1ccc2c(NC(=O)[C@]22CC[C@H](O)CC2)c1)C(=O)NC1CC1 |r,wU:18.20,wD:15.15,(14.49,-15.14,;15.83,-15.9,;17.16,-15.12,;18.5,-15.89,;18.51,-17.43,;17.18,-18.2,;15.84,-17.44,;14.51,-18.21,;14.52,-19.76,;13.18,-20.53,;11.85,-19.76,;11.85,-18.22,;10.39,-17.74,;9.48,-18.99,;7.94,-18.98,;10.38,-20.23,;8.89,-20.63,;8.49,-22.11,;9.58,-23.21,;9.17,-24.69,;11.07,-22.81,;11.48,-21.32,;13.18,-17.44,;19.84,-18.2,;19.85,-19.74,;21.17,-17.42,;22.51,-18.19,;23.29,-19.52,;24.05,-18.18,)| Show InChI InChI=1S/C24H26N2O3/c1-14-2-3-16(22(28)25-17-5-6-17)12-19(14)15-4-7-20-21(13-15)26-23(29)24(20)10-8-18(27)9-11-24/h2-4,7,12-13,17-18,27H,5-6,8-11H2,1H3,(H,25,28)(H,26,29)/t18-,24- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human p38alpha using biotinylated ATF2 substrate by FRET assay |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352567
(CHEMBL1825147 | US8772288, 22)Show SMILES Cc1ccc(cc1-c1ccc2c(NC(=O)C22CCOCC2)c1)C(=O)NC1CC1 Show InChI InChI=1S/C23H24N2O3/c1-14-2-3-16(21(26)24-17-5-6-17)12-18(14)15-4-7-19-20(13-15)25-22(27)23(19)8-10-28-11-9-23/h2-4,7,12-13,17H,5-6,8-11H2,1H3,(H,24,26)(H,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.65 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human p38alpha using biotinylated ATF2 substrate by FRET assay |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352573
(CHEMBL1825158)Show SMILES Cc1ccc(cc1-c1cnc2c(NC(=O)C22CCCC2)c1)C(=O)NC1CC1 Show InChI InChI=1S/C22H23N3O2/c1-13-4-5-14(20(26)24-16-6-7-16)10-17(13)15-11-18-19(23-12-15)22(21(27)25-18)8-2-3-9-22/h4-5,10-12,16H,2-3,6-9H2,1H3,(H,24,26)(H,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human p38alpha using biotinylated ATF2 substrate by FRET assay |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352574
(CHEMBL1825153 | US8772288, 32)Show SMILES Cc1ccc(cc1-c1ccc2c(NC(=O)C22CCC(F)(F)CC2)c1)C(=O)NC1CC1 Show InChI InChI=1S/C24H24F2N2O2/c1-14-2-3-16(21(29)27-17-5-6-17)12-18(14)15-4-7-19-20(13-15)28-22(30)23(19)8-10-24(25,26)11-9-23/h2-4,7,12-13,17H,5-6,8-11H2,1H3,(H,27,29)(H,28,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human p38alpha using biotinylated ATF2 substrate by FRET assay |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352575
(CHEMBL1825160)Show SMILES Cc1ccc(cc1-c1cnc2c(NC(=O)C22CCC(F)(F)CC2)c1)C(=O)NC1CC1 Show InChI InChI=1S/C23H23F2N3O2/c1-13-2-3-14(20(29)27-16-4-5-16)10-17(13)15-11-18-19(26-12-15)22(21(30)28-18)6-8-23(24,25)9-7-22/h2-3,10-12,16H,4-9H2,1H3,(H,27,29)(H,28,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human p38alpha using biotinylated ATF2 substrate by FRET assay |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352570
(CHEMBL1825154)Show SMILES Cc1ccc(cc1-c1ccc2c(NC(=O)C22CCC(F)(F)CC2)c1)C(=O)Nc1ccon1 Show InChI InChI=1S/C24H21F2N3O3/c1-14-2-3-16(21(30)28-20-6-11-32-29-20)12-17(14)15-4-5-18-19(13-15)27-22(31)23(18)7-9-24(25,26)10-8-23/h2-6,11-13H,7-10H2,1H3,(H,27,31)(H,28,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha in human whole blood assessed as reduction in TNF-alpha production by ELISA |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352568
(CHEMBL1825151)Show SMILES Cc1ccc(cc1-c1ccc2c(NC(=O)[C@@]22CC[C@H](O)CC2)c1)C(=O)NC1CC1 |r,wD:15.15,18.20,(-4.28,-16.05,;-2.94,-16.81,;-1.62,-16.03,;-.27,-16.8,;-.27,-18.34,;-1.6,-19.11,;-2.94,-18.35,;-4.26,-19.12,;-4.26,-20.67,;-5.59,-21.44,;-6.93,-20.67,;-6.92,-19.13,;-8.39,-18.65,;-9.29,-19.9,;-10.83,-19.89,;-8.39,-21.14,;-7.3,-22.23,;-7.71,-23.72,;-9.2,-24.12,;-9.6,-25.6,;-10.29,-23.02,;-9.89,-21.54,;-5.6,-18.35,;1.07,-19.11,;1.07,-20.65,;2.4,-18.33,;3.73,-19.1,;4.51,-20.43,;5.28,-19.09,)| Show InChI InChI=1S/C24H26N2O3/c1-14-2-3-16(22(28)25-17-5-6-17)12-19(14)15-4-7-20-21(13-15)26-23(29)24(20)10-8-18(27)9-11-24/h2-4,7,12-13,17-18,27H,5-6,8-11H2,1H3,(H,25,28)(H,26,29)/t18-,24+ | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha in human whole blood assessed as reduction in TNF-alpha production by ELISA |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352577
(CHEMBL1825145 | US8772288, 29)Show SMILES CN1CCC2(CC1)C(=O)Nc1cc(ccc21)-c1cc(ccc1C)C(=O)NC1CC1 Show InChI InChI=1S/C24H27N3O2/c1-15-3-4-17(22(28)25-18-6-7-18)13-19(15)16-5-8-20-21(14-16)26-23(29)24(20)9-11-27(2)12-10-24/h3-5,8,13-14,18H,6-7,9-12H2,1-2H3,(H,25,28)(H,26,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human p38alpha using biotinylated ATF2 substrate by FRET assay |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352576
(CHEMBL1825156 | US8772288, 43)Show SMILES Cc1ccc(cc1-c1ccc2c(NC(=O)C22CCCC2)n1)C(=O)NC1CC1 Show InChI InChI=1S/C22H23N3O2/c1-13-4-5-14(20(26)23-15-6-7-15)12-16(13)18-9-8-17-19(24-18)25-21(27)22(17)10-2-3-11-22/h4-5,8-9,12,15H,2-3,6-7,10-11H2,1H3,(H,23,26)(H,24,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human p38alpha using biotinylated ATF2 substrate by FRET assay |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352579
(CHEMBL1825150 | US8772288, 27)Show SMILES Cc1ccc(cc1-c1ccc2c(NC(=O)C22CCS(=O)(=O)CC2)c1)C(=O)NC1CC1 Show InChI InChI=1S/C23H24N2O4S/c1-14-2-3-16(21(26)24-17-5-6-17)12-18(14)15-4-7-19-20(13-15)25-22(27)23(19)8-10-30(28,29)11-9-23/h2-4,7,12-13,17H,5-6,8-11H2,1H3,(H,24,26)(H,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human p38alpha using biotinylated ATF2 substrate by FRET assay |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352566
(CHEMBL1825148 | US8772288, 23)Show SMILES Cc1ccc(cc1-c1ccc2c(NC(=O)C22CCOCC2)c1)C(=O)Nc1ccon1 Show InChI InChI=1S/C23H21N3O4/c1-14-2-3-16(21(27)25-20-6-9-30-26-20)12-17(14)15-4-5-18-19(13-15)24-22(28)23(18)7-10-29-11-8-23/h2-6,9,12-13H,7-8,10-11H2,1H3,(H,24,28)(H,25,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha in human whole blood assessed as reduction in TNF-alpha production by ELISA |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352578
(CHEMBL1825155)Show SMILES Cc1ncc(cc1-c1ccc2c(NC(=O)C22CCCC2)c1)C(=O)NC1CC1 Show InChI InChI=1S/C22H23N3O2/c1-13-17(10-15(12-23-13)20(26)24-16-5-6-16)14-4-7-18-19(11-14)25-21(27)22(18)8-2-3-9-22/h4,7,10-12,16H,2-3,5-6,8-9H2,1H3,(H,24,26)(H,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 7.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human p38alpha using biotinylated ATF2 substrate by FRET assay |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352577
(CHEMBL1825145 | US8772288, 29)Show SMILES CN1CCC2(CC1)C(=O)Nc1cc(ccc21)-c1cc(ccc1C)C(=O)NC1CC1 Show InChI InChI=1S/C24H27N3O2/c1-15-3-4-17(22(28)25-18-6-7-18)13-19(15)16-5-8-20-21(14-16)26-23(29)24(20)9-11-27(2)12-10-24/h3-5,8,13-14,18H,6-7,9-12H2,1-2H3,(H,25,28)(H,26,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha in human whole blood assessed as reduction in TNF-alpha production by ELISA |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352574
(CHEMBL1825153 | US8772288, 32)Show SMILES Cc1ccc(cc1-c1ccc2c(NC(=O)C22CCC(F)(F)CC2)c1)C(=O)NC1CC1 Show InChI InChI=1S/C24H24F2N2O2/c1-14-2-3-16(21(29)27-17-5-6-17)12-18(14)15-4-7-19-20(13-15)28-22(30)23(19)8-10-24(25,26)11-9-23/h2-4,7,12-13,17H,5-6,8-11H2,1H3,(H,27,29)(H,28,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha in human whole blood assessed as reduction in TNF-alpha production by ELISA |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50348323
(CHEMBL1800912)Show SMILES Cc1ccc(cc1-c1ccc2c(NC(=O)C22CCCCC2)c1)C(=O)NC1CC1 Show InChI InChI=1S/C24H26N2O2/c1-15-5-6-17(22(27)25-18-8-9-18)13-19(15)16-7-10-20-21(14-16)26-23(28)24(20)11-3-2-4-12-24/h5-7,10,13-14,18H,2-4,8-9,11-12H2,1H3,(H,25,27)(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha in human whole blood assessed as reduction in TNF-alpha production by ELISA |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352571
(CHEMBL1825152)Show SMILES Cc1ccc(cc1-c1ccc2c(NC(=O)[C@]22CC[C@H](O)CC2)c1)C(=O)NC1CC1 |r,wU:18.20,wD:15.15,(14.49,-15.14,;15.83,-15.9,;17.16,-15.12,;18.5,-15.89,;18.51,-17.43,;17.18,-18.2,;15.84,-17.44,;14.51,-18.21,;14.52,-19.76,;13.18,-20.53,;11.85,-19.76,;11.85,-18.22,;10.39,-17.74,;9.48,-18.99,;7.94,-18.98,;10.38,-20.23,;8.89,-20.63,;8.49,-22.11,;9.58,-23.21,;9.17,-24.69,;11.07,-22.81,;11.48,-21.32,;13.18,-17.44,;19.84,-18.2,;19.85,-19.74,;21.17,-17.42,;22.51,-18.19,;23.29,-19.52,;24.05,-18.18,)| Show InChI InChI=1S/C24H26N2O3/c1-14-2-3-16(22(28)25-17-5-6-17)12-19(14)15-4-7-20-21(13-15)26-23(29)24(20)10-8-18(27)9-11-24/h2-4,7,12-13,17-18,27H,5-6,8-11H2,1H3,(H,25,28)(H,26,29)/t18-,24- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha in human whole blood assessed as reduction in TNF-alpha production by ELISA |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352580
(CHEMBL1825159 | US8772288, 47)Show SMILES Cc1ccc(cc1-c1cnc2c(NC(=O)C22CCOCC2)c1)C(=O)NC1CC1 Show InChI InChI=1S/C22H23N3O3/c1-13-2-3-14(20(26)24-16-4-5-16)10-17(13)15-11-18-19(23-12-15)22(21(27)25-18)6-8-28-9-7-22/h2-3,10-12,16H,4-9H2,1H3,(H,24,26)(H,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human p38alpha using biotinylated ATF2 substrate by FRET assay |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352567
(CHEMBL1825147 | US8772288, 22)Show SMILES Cc1ccc(cc1-c1ccc2c(NC(=O)C22CCOCC2)c1)C(=O)NC1CC1 Show InChI InChI=1S/C23H24N2O3/c1-14-2-3-16(21(26)24-17-5-6-17)12-18(14)15-4-7-19-20(13-15)25-22(27)23(19)8-10-28-11-9-23/h2-4,7,12-13,17H,5-6,8-11H2,1H3,(H,24,26)(H,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha in human whole blood assessed as reduction in TNF-alpha production by ELISA |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352565
(CHEMBL1825149)Show SMILES Cc1ccc(cc1-c1ccc2c(NC(=O)C22CCSCC2)c1)C(=O)NC1CC1 Show InChI InChI=1S/C23H24N2O2S/c1-14-2-3-16(21(26)24-17-5-6-17)12-18(14)15-4-7-19-20(13-15)25-22(27)23(19)8-10-28-11-9-23/h2-4,7,12-13,17H,5-6,8-11H2,1H3,(H,24,26)(H,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha in human whole blood assessed as reduction in TNF-alpha production by ELISA |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352569
(CHEMBL1825146 | US8772288, 31)Show SMILES Cc1c(F)cc(cc1-c1ccc2c(NC(=O)C22CCN(CC2)S(C)(=O)=O)c1)C(=O)NC1CC1 Show InChI InChI=1S/C24H26FN3O4S/c1-14-18(11-16(12-20(14)25)22(29)26-17-4-5-17)15-3-6-19-21(13-15)27-23(30)24(19)7-9-28(10-8-24)33(2,31)32/h3,6,11-13,17H,4-5,7-10H2,1-2H3,(H,26,29)(H,27,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha in human whole blood assessed as reduction in TNF-alpha production by ELISA |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352581
(CHEMBL1825161 | US8772288, 45)Show SMILES Cc1ccc(cc1-c1cnc2c(NC(=O)C2(C)C)c1)C(=O)NC1CC1 Show InChI InChI=1S/C20H21N3O2/c1-11-4-5-12(18(24)22-14-6-7-14)8-15(11)13-9-16-17(21-10-13)20(2,3)19(25)23-16/h4-5,8-10,14H,6-7H2,1-3H3,(H,22,24)(H,23,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human p38alpha using biotinylated ATF2 substrate by FRET assay |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352572
(CHEMBL1825157 | US8772288, 51)Show SMILES Cc1ccc(cc1-c1cc2NC(=O)C3(CCCC3)c2cn1)C(=O)NC1CC1 Show InChI InChI=1S/C22H23N3O2/c1-13-4-5-14(20(26)24-15-6-7-15)10-16(13)18-11-19-17(12-23-18)22(21(27)25-19)8-2-3-9-22/h4-5,10-12,15H,2-3,6-9H2,1H3,(H,24,26)(H,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha in human whole blood assessed as reduction in TNF-alpha production by ELISA |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352573
(CHEMBL1825158)Show SMILES Cc1ccc(cc1-c1cnc2c(NC(=O)C22CCCC2)c1)C(=O)NC1CC1 Show InChI InChI=1S/C22H23N3O2/c1-13-4-5-14(20(26)24-16-6-7-16)10-17(13)15-11-18-19(23-12-15)22(21(27)25-18)8-2-3-9-22/h4-5,10-12,16H,2-3,6-9H2,1H3,(H,24,26)(H,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha in human whole blood assessed as reduction in TNF-alpha production by ELISA |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352582
(CHEMBL1825162 | US8772288, 52)Show SMILES Cc1ccc(cc1-c1ncc2c(NC(=O)C22CCCC2)n1)C(=O)NC1CC1 Show InChI InChI=1S/C21H22N4O2/c1-12-4-5-13(19(26)23-14-6-7-14)10-15(12)17-22-11-16-18(24-17)25-20(27)21(16)8-2-3-9-21/h4-5,10-11,14H,2-3,6-9H2,1H3,(H,23,26)(H,22,24,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 72 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human p38alpha using biotinylated ATF2 substrate by FRET assay |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352579
(CHEMBL1825150 | US8772288, 27)Show SMILES Cc1ccc(cc1-c1ccc2c(NC(=O)C22CCS(=O)(=O)CC2)c1)C(=O)NC1CC1 Show InChI InChI=1S/C23H24N2O4S/c1-14-2-3-16(21(26)24-17-5-6-17)12-18(14)15-4-7-19-20(13-15)25-22(27)23(19)8-10-30(28,29)11-9-23/h2-4,7,12-13,17H,5-6,8-11H2,1H3,(H,24,26)(H,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha in human whole blood assessed as reduction in TNF-alpha production by ELISA |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352580
(CHEMBL1825159 | US8772288, 47)Show SMILES Cc1ccc(cc1-c1cnc2c(NC(=O)C22CCOCC2)c1)C(=O)NC1CC1 Show InChI InChI=1S/C22H23N3O3/c1-13-2-3-14(20(26)24-16-4-5-16)10-17(13)15-11-18-19(23-12-15)22(21(27)25-18)6-8-28-9-7-22/h2-3,10-12,16H,4-9H2,1H3,(H,24,26)(H,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 86 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha in human whole blood assessed as reduction in TNF-alpha production by ELISA |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50352573
(CHEMBL1825158)Show SMILES Cc1ccc(cc1-c1cnc2c(NC(=O)C22CCCC2)c1)C(=O)NC1CC1 Show InChI InChI=1S/C22H23N3O2/c1-13-4-5-14(20(26)24-16-6-7-16)10-17(13)15-11-18-19(23-12-15)22(21(27)25-18)8-2-3-9-22/h4-5,10-12,16H,2-3,6-9H2,1H3,(H,24,26)(H,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 105 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human c-RAF |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50352567
(CHEMBL1825147 | US8772288, 22)Show SMILES Cc1ccc(cc1-c1ccc2c(NC(=O)C22CCOCC2)c1)C(=O)NC1CC1 Show InChI InChI=1S/C23H24N2O3/c1-14-2-3-16(21(26)24-17-5-6-17)12-18(14)15-4-7-19-20(13-15)25-22(27)23(19)8-10-28-11-9-23/h2-4,7,12-13,17H,5-6,8-11H2,1H3,(H,24,26)(H,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human c-RAF |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352576
(CHEMBL1825156 | US8772288, 43)Show SMILES Cc1ccc(cc1-c1ccc2c(NC(=O)C22CCCC2)n1)C(=O)NC1CC1 Show InChI InChI=1S/C22H23N3O2/c1-13-4-5-14(20(26)23-15-6-7-15)12-16(13)18-9-8-17-19(24-18)25-21(27)22(17)10-2-3-11-22/h4-5,8-9,12,15H,2-3,6-7,10-11H2,1H3,(H,23,26)(H,24,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 128 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha in human whole blood assessed as reduction in TNF-alpha production by ELISA |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352578
(CHEMBL1825155)Show SMILES Cc1ncc(cc1-c1ccc2c(NC(=O)C22CCCC2)c1)C(=O)NC1CC1 Show InChI InChI=1S/C22H23N3O2/c1-13-17(10-15(12-23-13)20(26)24-16-5-6-16)14-4-7-18-19(11-14)25-21(27)22(18)8-2-3-9-22/h4,7,10-12,16H,2-3,5-6,8-9H2,1H3,(H,24,26)(H,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha in human whole blood assessed as reduction in TNF-alpha production by ELISA |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352575
(CHEMBL1825160)Show SMILES Cc1ccc(cc1-c1cnc2c(NC(=O)C22CCC(F)(F)CC2)c1)C(=O)NC1CC1 Show InChI InChI=1S/C23H23F2N3O2/c1-13-2-3-14(20(29)27-16-4-5-16)10-17(13)15-11-18-19(26-12-15)22(21(30)28-18)6-8-23(24,25)9-7-22/h2-3,10-12,16H,4-9H2,1H3,(H,27,29)(H,28,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 188 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha in human whole blood assessed as reduction in TNF-alpha production by ELISA |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352581
(CHEMBL1825161 | US8772288, 45)Show SMILES Cc1ccc(cc1-c1cnc2c(NC(=O)C2(C)C)c1)C(=O)NC1CC1 Show InChI InChI=1S/C20H21N3O2/c1-11-4-5-12(18(24)22-14-6-7-14)8-15(11)13-9-16-17(21-10-13)20(2,3)19(25)23-16/h4-5,8-10,14H,6-7H2,1-3H3,(H,22,24)(H,23,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 544 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha in human whole blood assessed as reduction in TNF-alpha production by ELISA |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352582
(CHEMBL1825162 | US8772288, 52)Show SMILES Cc1ccc(cc1-c1ncc2c(NC(=O)C22CCCC2)n1)C(=O)NC1CC1 Show InChI InChI=1S/C21H22N4O2/c1-12-4-5-13(19(26)23-14-6-7-14)10-15(12)17-22-11-16-18(24-17)25-20(27)21(16)8-2-3-9-21/h4-5,10-11,14H,2-3,6-9H2,1H3,(H,23,26)(H,22,24,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha in human whole blood assessed as reduction in TNF-alpha production by ELISA |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352583
(CHEMBL1825144)Show SMILES Cc1ccc(cc1-c1ccc2c(NC(=O)C2(CCO)CCO)c1)C(=O)NC1CC1 Show InChI InChI=1S/C23H26N2O4/c1-14-2-3-16(21(28)24-17-5-6-17)12-18(14)15-4-7-19-20(13-15)25-22(29)23(19,8-10-26)9-11-27/h2-4,7,12-13,17,26-27H,5-6,8-11H2,1H3,(H,24,28)(H,25,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.57E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description
Inhibition of human p38alpha using biotinylated ATF2 substrate by FRET assay |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033
BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this
Ligand-Target Pair | |
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