Compile Data Set for Download or QSAR

Found 502 hits Enz. Inhib. hit(s) with all data for entry = 1822   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342204 (4-[4-[4-[5-(4-chlorophenyl)-4-methyl- 1H-imidazol-...) Show SMILES Cc1nc([nH]c1-c1ccc(Cl)cc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C28H24ClN7/c1-17-25(20-6-8-22(29)9-7-20)35-26(33-17)21-10-12-36(13-11-21)28-23-14-24(34-27(23)31-16-32-28)19-4-2-18(15-30)3-5-19/h2-9,14,16,21H,10-13H2,1H3,(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342205 (4-[4-[4-[5-(3,4-dimethoxyphenyl)-4- methyl-1H-imid...) Show SMILES COc1ccc(cc1OC)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C30H29N7O2/c1-18-27(22-8-9-25(38-2)26(14-22)39-3)36-28(34-18)21-10-12-37(13-11-21)30-23-15-24(35-29(23)32-17-33-30)20-6-4-19(16-31)5-7-20/h4-9,14-15,17,21H,10-13H2,1-3H3,(H,34,36)(H,32,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM342208 (6-(4-fluorophenyl)-4-[4-[5-(4- methoxyphenyl)-4-me...) Show SMILES COc1ccc(cc1)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C29H29FN6O/c1-18-25(20-6-10-22(37-3)11-7-20)35-28(33-18)29(2)12-14-36(15-13-29)27-23-16-24(34-26(23)31-17-32-27)19-4-8-21(30)9-5-19/h4-11,16-17H,12-15H2,1-3H3,(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342208 (6-(4-fluorophenyl)-4-[4-[5-(4- methoxyphenyl)-4-me...) Show SMILES COc1ccc(cc1)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C29H29FN6O/c1-18-25(20-6-10-22(37-3)11-7-20)35-28(33-18)29(2)12-14-36(15-13-29)27-23-16-24(34-26(23)31-17-32-27)19-4-8-21(30)9-5-19/h4-11,16-17H,12-15H2,1-3H3,(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM342209 (4-[4-[5-(4-methoxyphenyl)-4-methyl- 1H-imidazol-2-...) Show SMILES COc1ccc(cc1)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccnc(OC)c1 Show InChI InChI=1S/C29H31N7O2/c1-18-25(19-5-7-21(37-3)8-6-19)35-28(33-18)29(2)10-13-36(14-11-29)27-22-16-23(34-26(22)31-17-32-27)20-9-12-30-24(15-20)38-4/h5-9,12,15-17H,10-11,13-14H2,1-4H3,(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342209 (4-[4-[5-(4-methoxyphenyl)-4-methyl- 1H-imidazol-2-...) Show SMILES COc1ccc(cc1)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccnc(OC)c1 Show InChI InChI=1S/C29H31N7O2/c1-18-25(19-5-7-21(37-3)8-6-19)35-28(33-18)29(2)10-13-36(14-11-29)27-22-16-23(34-26(22)31-17-32-27)20-9-12-30-24(15-20)38-4/h5-9,12,15-17H,10-11,13-14H2,1-4H3,(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342210 (4-[4-[5-(3,4-dimethoxyphenyl)-4- methyl-1H-imidazo...) Show SMILES COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)c1nc(C)c([nH]1)-c1ccc(OC)c(OC)c1 Show InChI InChI=1S/C29H31N7O3/c1-17-26(20-5-6-23(37-2)24(13-20)38-3)35-27(33-17)18-8-11-36(12-9-18)29-21-15-22(34-28(21)31-16-32-29)19-7-10-30-25(14-19)39-4/h5-7,10,13-16,18H,8-9,11-12H2,1-4H3,(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM342211 (4-[4-[4-[5-(4-methoxyphenyl)-4-methyl- 1H-imidazol...) Show SMILES COc1ccc(cc1)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C30H29N7O/c1-19-26(22-8-10-23(38-3)11-9-22)36-29(34-19)30(2)12-14-37(15-13-30)28-24-16-25(35-27(24)32-18-33-28)21-6-4-20(17-31)5-7-21/h4-11,16,18H,12-15H2,1-3H3,(H,34,36)(H,32,33,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342211 (4-[4-[4-[5-(4-methoxyphenyl)-4-methyl- 1H-imidazol...) Show SMILES COc1ccc(cc1)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C30H29N7O/c1-19-26(22-8-10-23(38-3)11-9-22)36-29(34-19)30(2)12-14-37(15-13-30)28-24-16-25(35-27(24)32-18-33-28)21-6-4-20(17-31)5-7-21/h4-11,16,18H,12-15H2,1-3H3,(H,34,36)(H,32,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM342212 (4-[4-[4-(4-methyl-5-phenyl-1H- imidazol-2-yl)-1-pi...) Show SMILES Cc1nc([nH]c1-c1ccccc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C(N)=O Show InChI InChI=1S/C28H27N7O/c1-17-24(19-5-3-2-4-6-19)34-26(32-17)21-11-13-35(14-12-21)28-22-15-23(33-27(22)30-16-31-28)18-7-9-20(10-8-18)25(29)36/h2-10,15-16,21H,11-14H2,1H3,(H2,29,36)(H,32,34)(H,30,31,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342212 (4-[4-[4-(4-methyl-5-phenyl-1H- imidazol-2-yl)-1-pi...) Show SMILES Cc1nc([nH]c1-c1ccccc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C(N)=O Show InChI InChI=1S/C28H27N7O/c1-17-24(19-5-3-2-4-6-19)34-26(32-17)21-11-13-35(14-12-21)28-22-15-23(33-27(22)30-16-31-28)18-7-9-20(10-8-18)25(29)36/h2-10,15-16,21H,11-14H2,1H3,(H2,29,36)(H,32,34)(H,30,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342213 (6-(2-methoxypyrimidin-5-yl)-4-[4-(4- methyl-5-phen...) Show SMILES COc1ncc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)c1nc(C)c([nH]1)-c1ccccc1 Show InChI InChI=1S/C26H26N8O/c1-16-22(17-6-4-3-5-7-17)33-23(31-16)18-8-10-34(11-9-18)25-20-12-21(32-24(20)29-15-30-25)19-13-27-26(35-2)28-14-19/h3-7,12-15,18H,8-11H2,1-2H3,(H,31,33)(H,29,30,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM342214 (4-[4-(4-methyl-5-phenyl-1H-imidazol-2- yl)-1-piper...) Show SMILES Cc1nc([nH]c1-c1ccccc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1 Show InChI InChI=1S/C25H26N8/c1-16-22(17-6-4-3-5-7-17)31-23(29-16)18-8-10-33(11-9-18)25-20-12-21(19-13-28-32(2)14-19)30-24(20)26-15-27-25/h3-7,12-15,18H,8-11H2,1-2H3,(H,29,31)(H,26,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342214 (4-[4-(4-methyl-5-phenyl-1H-imidazol-2- yl)-1-piper...) Show SMILES Cc1nc([nH]c1-c1ccccc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1 Show InChI InChI=1S/C25H26N8/c1-16-22(17-6-4-3-5-7-17)31-23(29-16)18-8-10-33(11-9-18)25-20-12-21(19-13-28-32(2)14-19)30-24(20)26-15-27-25/h3-7,12-15,18H,8-11H2,1-2H3,(H,29,31)(H,26,27,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342215 (4-[4-[4-(4-methyl-5-phenyl-1H- imidazol-2-yl)-1-pi...) Show SMILES Cc1nc([nH]c1-c1ccccc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C28H25N7/c1-18-25(21-5-3-2-4-6-21)34-26(32-18)22-11-13-35(14-12-22)28-23-15-24(33-27(23)30-17-31-28)20-9-7-19(16-29)8-10-20/h2-10,15,17,22H,11-14H2,1H3,(H,32,34)(H,30,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342216 (4-[4-[4-(4-methyl-5-phenyl-1H- imidazol-2-yl)-1-pi...) Show SMILES Cc1nc([nH]c1-c1ccccc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)S(N)(=O)=O Show InChI InChI=1S/C27H27N7O2S/c1-17-24(19-5-3-2-4-6-19)33-25(31-17)20-11-13-34(14-12-20)27-22-15-23(32-26(22)29-16-30-27)18-7-9-21(10-8-18)37(28,35)36/h2-10,15-16,20H,11-14H2,1H3,(H,31,33)(H2,28,35,36)(H,29,30,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342217 (N-methyl-3-[4-[4-(4-methyl-5-phenyl- 1H-imidazol-2...) Show SMILES CNC(=O)c1cccc(c1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)c1nc(C)c([nH]1)-c1ccccc1 Show InChI InChI=1S/C29H29N7O/c1-18-25(19-7-4-3-5-8-19)35-26(33-18)20-11-13-36(14-12-20)28-23-16-24(34-27(23)31-17-32-28)21-9-6-10-22(15-21)29(37)30-2/h3-10,15-17,20H,11-14H2,1-2H3,(H,30,37)(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM342218 (6-[1-(difluoromethyl)pyrazol-4-yl]-4-[4- (4-methyl...) Show SMILES Cc1nc([nH]c1-c1ccccc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(c1)C(F)F Show InChI InChI=1S/C25H24F2N8/c1-15-21(16-5-3-2-4-6-16)33-22(31-15)17-7-9-34(10-8-17)24-19-11-20(32-23(19)28-14-29-24)18-12-30-35(13-18)25(26)27/h2-6,11-14,17,25H,7-10H2,1H3,(H,31,33)(H,28,29,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342218 (6-[1-(difluoromethyl)pyrazol-4-yl]-4-[4- (4-methyl...) Show SMILES Cc1nc([nH]c1-c1ccccc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(c1)C(F)F Show InChI InChI=1S/C25H24F2N8/c1-15-21(16-5-3-2-4-6-16)33-22(31-15)17-7-9-34(10-8-17)24-19-11-20(32-23(19)28-14-29-24)18-12-30-35(13-18)25(26)27/h2-6,11-14,17,25H,7-10H2,1H3,(H,31,33)(H,28,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM342219 (3-[4-[4-(4-methyl-5-phenyl-1H- imidazol-2-yl)-1-pi...) Show SMILES Cc1nc([nH]c1-c1ccccc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cccc(c1)S(N)(=O)=O Show InChI InChI=1S/C27H27N7O2S/c1-17-24(18-6-3-2-4-7-18)33-25(31-17)19-10-12-34(13-11-19)27-22-15-23(32-26(22)29-16-30-27)20-8-5-9-21(14-20)37(28,35)36/h2-9,14-16,19H,10-13H2,1H3,(H,31,33)(H2,28,35,36)(H,29,30,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342219 (3-[4-[4-(4-methyl-5-phenyl-1H- imidazol-2-yl)-1-pi...) Show SMILES Cc1nc([nH]c1-c1ccccc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cccc(c1)S(N)(=O)=O Show InChI InChI=1S/C27H27N7O2S/c1-17-24(18-6-3-2-4-7-18)33-25(31-17)19-10-12-34(13-11-19)27-22-15-23(32-26(22)29-16-30-27)20-8-5-9-21(14-20)37(28,35)36/h2-9,14-16,19H,10-13H2,1H3,(H,31,33)(H2,28,35,36)(H,29,30,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM342220 (6-(4-fluorophenyl)-4-[4-[5-(4-methoxy- 3-methyl-ph...) Show SMILES COc1ccc(cc1C)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C30H31FN6O/c1-18-15-21(7-10-25(18)38-4)26-19(2)34-29(36-26)30(3)11-13-37(14-12-30)28-23-16-24(35-27(23)32-17-33-28)20-5-8-22(31)9-6-20/h5-10,15-17H,11-14H2,1-4H3,(H,34,36)(H,32,33,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342220 (6-(4-fluorophenyl)-4-[4-[5-(4-methoxy- 3-methyl-ph...) Show SMILES COc1ccc(cc1C)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C30H31FN6O/c1-18-15-21(7-10-25(18)38-4)26-19(2)34-29(36-26)30(3)11-13-37(14-12-30)28-23-16-24(35-27(23)32-17-33-28)20-5-8-22(31)9-6-20/h5-10,15-17H,11-14H2,1-4H3,(H,34,36)(H,32,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM342221 (4-[4-[4-[5-(4-methoxy-3-methyl- phenyl)-4-methyl-1...) Show SMILES COc1ccc(cc1C)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C31H31N7O/c1-19-15-23(9-10-26(19)39-4)27-20(2)35-30(37-27)31(3)11-13-38(14-12-31)29-24-16-25(36-28(24)33-18-34-29)22-7-5-21(17-32)6-8-22/h5-10,15-16,18H,11-14H2,1-4H3,(H,35,37)(H,33,34,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342221 (4-[4-[4-[5-(4-methoxy-3-methyl- phenyl)-4-methyl-1...) Show SMILES COc1ccc(cc1C)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C31H31N7O/c1-19-15-23(9-10-26(19)39-4)27-20(2)35-30(37-27)31(3)11-13-38(14-12-31)29-24-16-25(36-28(24)33-18-34-29)22-7-5-21(17-32)6-8-22/h5-10,15-16,18H,11-14H2,1-4H3,(H,35,37)(H,33,34,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM342222 (4-[4-[5-(4-methoxy-3-methyl-phenyl)-4- methyl-1H-i...) Show SMILES COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCC(C)(CC1)c1nc(C)c([nH]1)-c1ccc(OC)c(C)c1 Show InChI InChI=1S/C30H33N7O2/c1-18-14-21(6-7-24(18)38-4)26-19(2)34-29(36-26)30(3)9-12-37(13-10-30)28-22-16-23(35-27(22)32-17-33-28)20-8-11-31-25(15-20)39-5/h6-8,11,14-17H,9-10,12-13H2,1-5H3,(H,34,36)(H,32,33,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342222 (4-[4-[5-(4-methoxy-3-methyl-phenyl)-4- methyl-1H-i...) Show SMILES COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCC(C)(CC1)c1nc(C)c([nH]1)-c1ccc(OC)c(C)c1 Show InChI InChI=1S/C30H33N7O2/c1-18-14-21(6-7-24(18)38-4)26-19(2)34-29(36-26)30(3)9-12-37(13-10-30)28-22-16-23(35-27(22)32-17-33-28)20-8-11-31-25(15-20)39-5/h6-8,11,14-17H,9-10,12-13H2,1-5H3,(H,34,36)(H,32,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM342223 (4-[4-ethyl-4-[5-(4-methoxyphenyl)-4- methyl-1H-imi...) Show SMILES CCC1(CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1nc(C)c([nH]1)-c1ccc(OC)cc1 Show InChI InChI=1S/C30H31FN6O/c1-4-30(29-34-19(2)26(36-29)21-7-11-23(38-3)12-8-21)13-15-37(16-14-30)28-24-17-25(35-27(24)32-18-33-28)20-5-9-22(31)10-6-20/h5-12,17-18H,4,13-16H2,1-3H3,(H,34,36)(H,32,33,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342223 (4-[4-ethyl-4-[5-(4-methoxyphenyl)-4- methyl-1H-imi...) Show SMILES CCC1(CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1nc(C)c([nH]1)-c1ccc(OC)cc1 Show InChI InChI=1S/C30H31FN6O/c1-4-30(29-34-19(2)26(36-29)21-7-11-23(38-3)12-8-21)13-15-37(16-14-30)28-24-17-25(35-27(24)32-18-33-28)20-5-9-22(31)10-6-20/h5-12,17-18H,4,13-16H2,1-3H3,(H,34,36)(H,32,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM342224 (4-[4-ethyl-4-[5-(4-methoxy-3-methyl- phenyl)-4-met...) Show SMILES CCC1(CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1nc(C)c([nH]1)-c1ccc(OC)c(C)c1 Show InChI InChI=1S/C31H33FN6O/c1-5-31(30-35-20(3)27(37-30)22-8-11-26(39-4)19(2)16-22)12-14-38(15-13-31)29-24-17-25(36-28(24)33-18-34-29)21-6-9-23(32)10-7-21/h6-11,16-18H,5,12-15H2,1-4H3,(H,35,37)(H,33,34,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342224 (4-[4-ethyl-4-[5-(4-methoxy-3-methyl- phenyl)-4-met...) Show SMILES CCC1(CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1nc(C)c([nH]1)-c1ccc(OC)c(C)c1 Show InChI InChI=1S/C31H33FN6O/c1-5-31(30-35-20(3)27(37-30)22-8-11-26(39-4)19(2)16-22)12-14-38(15-13-31)29-24-17-25(36-28(24)33-18-34-29)21-6-9-23(32)10-7-21/h6-11,16-18H,5,12-15H2,1-4H3,(H,35,37)(H,33,34,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM342225 (6-(4-fluorophenyl)-4-[4-[5-(4- fluorophenyl)-4-met...) Show SMILES Cc1nc([nH]c1-c1ccc(F)cc1)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C28H26F2N6/c1-17-24(19-5-9-21(30)10-6-19)35-27(33-17)28(2)11-13-36(14-12-28)26-22-15-23(34-25(22)31-16-32-26)18-3-7-20(29)8-4-18/h3-10,15-16H,11-14H2,1-2H3,(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342225 (6-(4-fluorophenyl)-4-[4-[5-(4- fluorophenyl)-4-met...) Show SMILES Cc1nc([nH]c1-c1ccc(F)cc1)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C28H26F2N6/c1-17-24(19-5-9-21(30)10-6-19)35-27(33-17)28(2)11-13-36(14-12-28)26-22-15-23(34-25(22)31-16-32-26)18-3-7-20(29)8-4-18/h3-10,15-16H,11-14H2,1-2H3,(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM342226 (4-[4-[5-(4-chlorophenyl)-4-methyl-1H- imidazol-2-y...) Show SMILES Cc1nc([nH]c1-c1ccc(Cl)cc1)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C28H26ClFN6/c1-17-24(19-3-7-20(29)8-4-19)35-27(33-17)28(2)11-13-36(14-12-28)26-22-15-23(34-25(22)31-16-32-26)18-5-9-21(30)10-6-18/h3-10,15-16H,11-14H2,1-2H3,(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342226 (4-[4-[5-(4-chlorophenyl)-4-methyl-1H- imidazol-2-y...) Show SMILES Cc1nc([nH]c1-c1ccc(Cl)cc1)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C28H26ClFN6/c1-17-24(19-3-7-20(29)8-4-19)35-27(33-17)28(2)11-13-36(14-12-28)26-22-15-23(34-25(22)31-16-32-26)18-5-9-21(30)10-6-18/h3-10,15-16H,11-14H2,1-2H3,(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM342227 (4-[4-[5-(4-ethylphenyl)-4-methyl-1H- imidazol-2-yl...) Show SMILES CCc1ccc(cc1)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccnc(OC)c1 Show InChI InChI=1S/C29H31N7O/c1-4-19-5-7-20(8-6-19)26-18(2)33-27(35-26)21-10-13-36(14-11-21)29-23-16-24(34-28(23)31-17-32-29)22-9-12-30-25(15-22)37-3/h5-9,12,15-17,21H,4,10-11,13-14H2,1-3H3,(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342227 (4-[4-[5-(4-ethylphenyl)-4-methyl-1H- imidazol-2-yl...) Show SMILES CCc1ccc(cc1)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccnc(OC)c1 Show InChI InChI=1S/C29H31N7O/c1-4-19-5-7-20(8-6-19)26-18(2)33-27(35-26)21-10-13-36(14-11-21)29-23-16-24(34-28(23)31-17-32-29)22-9-12-30-25(15-22)37-3/h5-9,12,15-17,21H,4,10-11,13-14H2,1-3H3,(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM342228 (4-[4-[5-(4-ethylphenyl)-4-methyl-1H- imidazol-2-yl...) Show SMILES CCc1ccc(cc1)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C29H29FN6/c1-3-19-4-6-21(7-5-19)26-18(2)33-27(35-26)22-12-14-36(15-13-22)29-24-16-25(34-28(24)31-17-32-29)20-8-10-23(30)11-9-20/h4-11,16-17,22H,3,12-15H2,1-2H3,(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342228 (4-[4-[5-(4-ethylphenyl)-4-methyl-1H- imidazol-2-yl...) Show SMILES CCc1ccc(cc1)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C29H29FN6/c1-3-19-4-6-21(7-5-19)26-18(2)33-27(35-26)22-12-14-36(15-13-22)29-24-16-25(34-28(24)31-17-32-29)20-8-10-23(30)11-9-20/h4-11,16-17,22H,3,12-15H2,1-2H3,(H,33,35)(H,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM342229 (4-[4-[4-[5-(4-ethylphenyl)-4-methyl-1H- imidazol-2...) Show SMILES CCc1ccc(cc1)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C30H29N7/c1-3-20-4-10-23(11-5-20)27-19(2)34-28(36-27)24-12-14-37(15-13-24)30-25-16-26(35-29(25)32-18-33-30)22-8-6-21(17-31)7-9-22/h4-11,16,18,24H,3,12-15H2,1-2H3,(H,34,36)(H,32,33,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342229 (4-[4-[4-[5-(4-ethylphenyl)-4-methyl-1H- imidazol-2...) Show SMILES CCc1ccc(cc1)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C30H29N7/c1-3-20-4-10-23(11-5-20)27-19(2)34-28(36-27)24-12-14-37(15-13-24)30-25-16-26(35-29(25)32-18-33-30)22-8-6-21(17-31)7-9-22/h4-11,16,18,24H,3,12-15H2,1-2H3,(H,34,36)(H,32,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM342230 (6-(4-fluorophenyl)-4-[4-[4-methyl-5-(p- tolyl)-1H-...) Show SMILES Cc1nc([nH]c1-c1ccc(C)cc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C28H27FN6/c1-17-3-5-20(6-4-17)25-18(2)32-26(34-25)21-11-13-35(14-12-21)28-23-15-24(33-27(23)30-16-31-28)19-7-9-22(29)10-8-19/h3-10,15-16,21H,11-14H2,1-2H3,(H,32,34)(H,30,31,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342230 (6-(4-fluorophenyl)-4-[4-[4-methyl-5-(p- tolyl)-1H-...) Show SMILES Cc1nc([nH]c1-c1ccc(C)cc1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C28H27FN6/c1-17-3-5-20(6-4-17)25-18(2)32-26(34-25)21-11-13-35(14-12-21)28-23-15-24(33-27(23)30-16-31-28)19-7-9-22(29)10-8-19/h3-10,15-16,21H,11-14H2,1-2H3,(H,32,34)(H,30,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342231 (4-[4-[5-(4-methoxyphenyl)-4-methyl- 1H-imidazol-2-...) Show SMILES COc1ccc(cc1)-c1[nH]c(nc1C)C1(C)CCN(CC1)c1ncnc2[nH]c(C)cc12 Show InChI InChI=1S/C24H28N6O/c1-15-13-19-21(27-15)25-14-26-22(19)30-11-9-24(3,10-12-30)23-28-16(2)20(29-23)17-5-7-18(31-4)8-6-17/h5-8,13-14H,9-12H2,1-4H3,(H,28,29)(H,25,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342232 (4-[4-[5-(4-fluorophenyl)-4-methyl-1H- imidazol-2-y...) Show SMILES Cc1cc2c(ncnc2[nH]1)N1CCC(C)(CC1)c1nc(C)c([nH]1)-c1ccc(F)cc1 Show InChI InChI=1S/C23H25FN6/c1-14-12-18-20(27-14)25-13-26-21(18)30-10-8-23(3,9-11-30)22-28-15(2)19(29-22)16-4-6-17(24)7-5-16/h4-7,12-13H,8-11H2,1-3H3,(H,28,29)(H,25,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM342233 (4-[4-[5-(4-ethoxy-3-methyl-phenyl)-4- methyl-1H-im...) Show SMILES CCOc1ccc(cc1C)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C30H31FN6O/c1-4-38-26-10-7-22(15-18(26)2)27-19(3)34-28(36-27)21-11-13-37(14-12-21)30-24-16-25(35-29(24)32-17-33-30)20-5-8-23(31)9-6-20/h5-10,15-17,21H,4,11-14H2,1-3H3,(H,34,36)(H,32,33,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342233 (4-[4-[5-(4-ethoxy-3-methyl-phenyl)-4- methyl-1H-im...) Show SMILES CCOc1ccc(cc1C)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C30H31FN6O/c1-4-38-26-10-7-22(15-18(26)2)27-19(3)34-28(36-27)21-11-13-37(14-12-21)30-24-16-25(35-29(24)32-17-33-30)20-5-8-23(31)9-6-20/h5-10,15-17,21H,4,11-14H2,1-3H3,(H,34,36)(H,32,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM342234 (4-[4-[4-[5-(4-ethoxy-3-methyl-phenyl)- 4-methyl-1H...) Show SMILES CCOc1ccc(cc1C)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C31H31N7O/c1-4-39-27-10-9-24(15-19(27)2)28-20(3)35-29(37-28)23-11-13-38(14-12-23)31-25-16-26(36-30(25)33-18-34-31)22-7-5-21(17-32)6-8-22/h5-10,15-16,18,23H,4,11-14H2,1-3H3,(H,35,37)(H,33,34,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342234 (4-[4-[4-[5-(4-ethoxy-3-methyl-phenyl)- 4-methyl-1H...) Show SMILES CCOc1ccc(cc1C)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N Show InChI InChI=1S/C31H31N7O/c1-4-39-27-10-9-24(15-19(27)2)28-20(3)35-29(37-28)23-11-13-38(14-12-23)31-25-16-26(36-30(25)33-18-34-31)22-7-5-21(17-32)6-8-22/h5-10,15-16,18,23H,4,11-14H2,1-3H3,(H,35,37)(H,33,34,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM342235 (4-[4-[5-(4-ethoxy-3-methyl-phenyl)-4- methyl-1H-im...) Show SMILES CCOc1ccc(cc1C)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccnc(OC)c1 Show InChI InChI=1S/C30H33N7O2/c1-5-39-25-7-6-22(14-18(25)2)27-19(3)34-28(36-27)20-9-12-37(13-10-20)30-23-16-24(35-29(23)32-17-33-30)21-8-11-31-26(15-21)38-4/h6-8,11,14-17,20H,5,9-10,12-13H2,1-4H3,(H,34,36)(H,32,33,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair

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