Compile Data Set for Download or QSAR

Found 309 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 1833   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM349184 (Cyclopropanecarboxylic acid (5-{4-[2-oxo-2-(4- tri...) Show SMILES FC(F)(F)C1CCN(CC1)C(=O)Cc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C24H24F3N5O2/c25-24(26,27)18-10-12-31(13-11-18)21(33)14-15-4-6-16(7-5-15)19-2-1-3-20-28-23(30-32(19)20)29-22(34)17-8-9-17/h1-7,17-18H,8-14H2,(H,29,30,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM349186 (Cyclopropanecarboxylic acid (5-{4-[2-(3-methoxy-az...) Show SMILES COC1CN(C1)C(=O)Cc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C22H23N5O3/c1-30-17-12-26(13-17)20(28)11-14-5-7-15(8-6-14)18-3-2-4-19-23-22(25-27(18)19)24-21(29)16-9-10-16/h2-8,16-17H,9-13H2,1H3,(H,24,25,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM349190 (Cyclopropanecarboxylic acid (5-{4-[3-(4-cyano-benz...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)N3CC(C3)OCc3ccc(cc3)C#N)n2n1)C1CC1 Show InChI InChI=1S/C28H24N6O3/c29-14-18-4-6-19(7-5-18)17-37-23-15-33(16-23)27(36)22-12-8-20(9-13-22)24-2-1-3-25-30-28(32-34(24)25)31-26(35)21-10-11-21/h1-9,12-13,21,23H,10-11,15-17H2,(H,31,32,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM349193 (Cyclopropanecarboxylic acid {5-[4-(3-cyano-azetidi...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)N3CC(C3)C#N)n2n1)C1CC1 Show InChI InChI=1S/C21H18N6O2/c22-10-13-11-26(12-13)20(29)16-8-4-14(5-9-16)17-2-1-3-18-23-21(25-27(17)18)24-19(28)15-6-7-15/h1-5,8-9,13,15H,6-7,11-12H2,(H,24,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM128101 (US10206907, Compound 330 | US8796457, 1 | US950575...) Show SMILES CC1(C)CN(C1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C22H23N5O2/c1-22(2)12-26(13-22)20(29)16-10-6-14(7-11-16)17-4-3-5-18-23-21(25-27(17)18)24-19(28)15-8-9-15/h3-7,10-11,15H,8-9,12-13H2,1-2H3,(H,24,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM348894 (N-(5-(biphenyl-4-yl)- [1,2,4]triazolo[1,5-a]pyridi...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)-c3ccccc3)n2n1)C1CC1 Show InChI InChI=1S/C22H18N4O/c27-21(18-13-14-18)24-22-23-20-8-4-7-19(26(20)25-22)17-11-9-16(10-12-17)15-5-2-1-3-6-15/h1-12,18H,13-14H2,(H,24,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM348897 (N-(5-(4-benzoylphenyl)- [1,2,4]triazolo[1,5-a]pyri...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)c3ccccc3)n2n1)C1CC1 Show InChI InChI=1S/C23H18N4O2/c28-21(16-5-2-1-3-6-16)17-11-9-15(10-12-17)19-7-4-8-20-24-23(26-27(19)20)25-22(29)18-13-14-18/h1-12,18H,13-14H2,(H,25,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM348899 (N-(5-(4-(benzyloxy)phenyl)- [1,2,4]triazolo[1,5-a]...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(OCc4ccccc4)cc3)n2n1)C1CC1 Show InChI InChI=1S/C23H20N4O2/c28-22(18-9-10-18)25-23-24-21-8-4-7-20(27(21)26-23)17-11-13-19(14-12-17)29-15-16-5-2-1-3-6-16/h1-8,11-14,18H,9-10,15H2,(H,25,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM348900 (N-(5-(4-(N- cyclopropylsulfamoyl)phenyl)- [1,2,4]t...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)S(=O)(=O)NC3CC3)n2n1)C1CC1 Show InChI InChI=1S/C19H19N5O3S/c25-18(13-4-5-13)21-19-20-17-3-1-2-16(24(17)22-19)12-6-10-15(11-7-12)28(26,27)23-14-8-9-14/h1-3,6-7,10-11,13-14,23H,4-5,8-9H2,(H,21,22,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM348902 (N-(5-(4-(benzyloxy)-3- fluorophenyl)- [1,2,4]triaz...) Show SMILES Fc1cc(ccc1OCc1ccccc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C23H19FN4O2/c24-18-13-17(11-12-20(18)30-14-15-5-2-1-3-6-15)19-7-4-8-21-25-23(27-28(19)21)26-22(29)16-9-10-16/h1-8,11-13,16H,9-10,14H2,(H,26,27,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM348903 (N-(5-(4-(piperidine-1- carbonyl(phenyl)- [1,2,4]tr...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)N3CCCCC3)n2n1)C1CC1 Show InChI InChI=1S/C22H23N5O2/c28-20(16-9-10-16)24-22-23-19-6-4-5-18(27(19)25-22)15-7-11-17(12-8-15)21(29)26-13-2-1-3-14-26/h4-8,11-12,16H,1-3,9-10,13-14H2,(H,24,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM103728 (US10206907, Compound 18 | US11000528, Cpd # 2 | US...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(CN4CCOCC4)cc3)n2n1)C1CC1 Show InChI InChI=1S/C21H23N5O2/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-28-13-11-25/h1-7,17H,8-14H2,(H,23,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM348905 (N-(5-(4-(pyrrolidine-1- carbonyl)phenyl)- [1,2,4]t...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)N3CCCC3)n2n1)C1CC1 Show InChI InChI=1S/C21H21N5O2/c27-19(15-8-9-15)23-21-22-18-5-3-4-17(26(18)24-21)14-6-10-16(11-7-14)20(28)25-12-1-2-13-25/h3-7,10-11,15H,1-2,8-9,12-13H2,(H,23,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM348907 (N-(4-(2- (cyclopropanecarboxamido)- [1,2,4]triazol...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(NC(=O)c4ccccc4)cc3)n2n1)C1CC1 Show InChI InChI=1S/C23H19N5O2/c29-21(16-5-2-1-3-6-16)24-18-13-11-15(12-14-18)19-7-4-8-20-25-23(27-28(19)20)26-22(30)17-9-10-17/h1-8,11-14,17H,9-10H2,(H,24,29)(H,26,27,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM348909 (N-(5-(4-(2- phenylacetamido)phenyl)- [1,2,4]triazo...) Show SMILES O=C(Cc1ccccc1)Nc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C24H21N5O2/c30-22(15-16-5-2-1-3-6-16)25-19-13-11-17(12-14-19)20-7-4-8-21-26-24(28-29(20)21)27-23(31)18-9-10-18/h1-8,11-14,18H,9-10,15H2,(H,25,30)(H,27,28,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM348911 (4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)Nc3ccncc3)n2n1)C1CC1 Show InChI InChI=1S/C22H18N6O2/c29-20(24-17-10-12-23-13-11-17)15-6-4-14(5-7-15)18-2-1-3-19-25-22(27-28(18)19)26-21(30)16-8-9-16/h1-7,10-13,16H,8-9H2,(H,23,24,29)(H,26,27,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM348915 (4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1...) Show SMILES Fc1cccc(CNC(=O)c2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)c1 Show InChI InChI=1S/C24H20FN5O2/c25-19-4-1-3-15(13-19)14-26-22(31)17-9-7-16(8-10-17)20-5-2-6-21-27-24(29-30(20)21)28-23(32)18-11-12-18/h1-10,13,18H,11-12,14H2,(H,26,31)(H,28,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM348916 (4-(2- (cyclopropanecarboxamido)- [1,2.4]triazolo[1...) Show SMILES CN(C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12)c1ccccc1 Show InChI InChI=1S/C24H21N5O2/c1-28(19-6-3-2-4-7-19)23(31)18-14-10-16(11-15-18)20-8-5-9-21-25-24(27-29(20)21)26-22(30)17-12-13-17/h2-11,14-15,17H,12-13H2,1H3,(H,26,27,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM348917 (4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1...) Show SMILES COc1ccc(CN(C)C(=O)c2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)cc1 Show InChI InChI=1S/C26H25N5O3/c1-30(16-17-6-14-21(34-2)15-7-17)25(33)20-12-8-18(9-13-20)22-4-3-5-23-27-26(29-31(22)23)28-24(32)19-10-11-19/h3-9,12-15,19H,10-11,16H2,1-2H3,(H,28,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM348919 (N-(5-(4-(4- fluorophenylsulfonamido) phenyl)-[1,2,...) Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C22H18FN5O3S/c23-16-8-12-18(13-9-16)32(30,31)27-17-10-6-14(7-11-17)19-2-1-3-20-24-22(26-28(19)20)25-21(29)15-4-5-15/h1-3,6-13,15,27H,4-5H2,(H,25,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM348922 (N-(5-(4-(pyridin-3- ylmethoxy)phenyl)- [1,2,4]tria...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(OCc4cccnc4)cc3)n2n1)C1CC1 Show InChI InChI=1S/C22H19N5O2/c28-21(17-6-7-17)25-22-24-20-5-1-4-19(27(20)26-22)16-8-10-18(11-9-16)29-14-15-3-2-12-23-13-15/h1-5,8-13,17H,6-7,14H2,(H,25,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM348923 (N-(5-(4-(pyridin-2- ylmethoxy)phenyl)- [1,2,4]tria...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(OCc4ccccn4)cc3)n2n1)C1CC1 Show InChI InChI=1S/C22H19N5O2/c28-21(16-7-8-16)25-22-24-20-6-3-5-19(27(20)26-22)15-9-11-18(12-10-15)29-14-17-4-1-2-13-23-17/h1-6,9-13,16H,7-8,14H2,(H,25,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM348961 (N-(5-(4-(4-benzyl-1,4- diazepane-1-carbonyl)phenyl...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)N3CCCN(Cc4ccccc4)CC3)n2n1)C1CC1 Show InChI InChI=1S/C29H30N6O2/c36-27(23-12-13-23)31-29-30-26-9-4-8-25(35(26)32-29)22-10-14-24(15-11-22)28(37)34-17-5-16-33(18-19-34)20-21-6-2-1-3-7-21/h1-4,6-11,14-15,23H,5,12-13,16-20H2,(H,31,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM348972 (N-(5-(2-fluoro-4-(piperidine- 1-carbonyl)phenyl)- ...) Show SMILES Fc1cc(ccc1-c1cccc2nc(NC(=O)C3CC3)nn12)C(=O)N1CCCCC1 Show InChI InChI=1S/C22H22FN5O2/c23-17-13-15(21(30)27-11-2-1-3-12-27)9-10-16(17)18-5-4-6-19-24-22(26-28(18)19)25-20(29)14-7-8-14/h4-6,9-10,13-14H,1-3,7-8,11-12H2,(H,25,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM349006 (4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)NCCc3cccnc3)n2n1)C1CC1 Show InChI InChI=1S/C24H22N6O2/c31-22(26-14-12-16-3-2-13-25-15-16)18-8-6-17(7-9-18)20-4-1-5-21-27-24(29-30(20)21)28-23(32)19-10-11-19/h1-9,13,15,19H,10-12,14H2,(H,26,31)(H,28,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM349032 (N-benzyl-4-(2- (cyclopropanecarboxamido)- [1,2,4]t...) Show SMILES CN(C)CCN(Cc1ccccc1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C28H30N6O2/c1-32(2)17-18-33(19-20-7-4-3-5-8-20)27(36)23-15-11-21(12-16-23)24-9-6-10-25-29-28(31-34(24)25)30-26(35)22-13-14-22/h3-12,15-16,22H,13-14,17-19H2,1-2H3,(H,30,31,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM349065 (Cyclopropanecarboxylic Acid (5-{4-[6-(2H-tetrazol-...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(OCc4ccc(nc4)-c4nnn[nH]4)cc3)n2n1)C1CC1 Show InChI InChI=1S/C23H19N9O2/c33-22(16-5-6-16)26-23-25-20-3-1-2-19(32(20)29-23)15-7-9-17(10-8-15)34-13-14-4-11-18(24-12-14)21-27-30-31-28-21/h1-4,7-12,16H,5-6,13H2,(H,26,29,33)(H,27,28,30,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM349073 (5-{4-[2-(Cyclopropanecarbonyl-amino)-[1,2,4]triazo...) Show SMILES NC(=O)c1ccc(COc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)cn1 Show InChI InChI=1S/C23H20N6O3/c24-21(30)18-11-4-14(12-25-18)13-32-17-9-7-15(8-10-17)19-2-1-3-20-26-23(28-29(19)20)27-22(31)16-5-6-16/h1-4,7-12,16H,5-6,13H2,(H2,24,30)(H,27,28,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM349082 (Cyclopropanecarboxylic acid (5-{4-[2-(3,5-dimethyl...) Show SMILES Cc1noc(C)c1CCOc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C23H23N5O3/c1-14-19(15(2)31-27-14)12-13-30-18-10-8-16(9-11-18)20-4-3-5-21-24-23(26-28(20)21)25-22(29)17-6-7-17/h3-5,8-11,17H,6-7,12-13H2,1-2H3,(H,25,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM349108 (4-{4-[2- (Cyclopropanecarbonyl- amino)-[1,2,4]tria...) Show SMILES NC(=O)c1ccc(NCc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)cc1 Show InChI InChI=1S/C24H22N6O2/c25-22(31)17-10-12-19(13-11-17)26-14-15-4-6-16(7-5-15)20-2-1-3-21-27-24(29-30(20)21)28-23(32)18-8-9-18/h1-7,10-13,18,26H,8-9,14H2,(H2,25,31)(H,28,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM349116 (Cyclopropanecarboxylic acid [5-(4-{[6-(4-methyl-pi...) Show SMILES CN1CCN(CC1)c1ccc(NCc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)cn1 Show InChI InChI=1S/C27H30N8O/c1-33-13-15-34(16-14-33)24-12-11-22(18-29-24)28-17-19-5-7-20(8-6-19)23-3-2-4-25-30-27(32-35(23)25)31-26(36)21-9-10-21/h2-8,11-12,18,21,28H,9-10,13-17H2,1H3,(H,31,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM349137 (Cyclopropanecarboxylic acid (5-[4-(3,3-difluoro- p...) Show SMILES FC1(F)CCN(C1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C21H19F2N5O2/c22-21(23)10-11-27(12-21)19(30)15-8-4-13(5-9-15)16-2-1-3-17-24-20(26-28(16)17)25-18(29)14-6-7-14/h1-5,8-9,14H,6-7,10-12H2,(H,25,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM349146 (Cyclopropanecarboxylic acid {5-[4-(3-fluoro-piperi...) Show SMILES FC1CCCN(Cc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)C1 Show InChI InChI=1S/C22H24FN5O/c23-18-3-2-12-27(14-18)13-15-6-8-16(9-7-15)19-4-1-5-20-24-22(26-28(19)20)25-21(29)17-10-11-17/h1,4-9,17-18H,2-3,10-14H2,(H,25,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM349154 (Cyclopropanecarboxylic acid {5-[4-(3-cyano-azetidi...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)N3CC(C3)C#N)n2n1)C1CC1 Show InChI InChI=1S/C20H18N6O/c21-10-13-11-25(12-13)16-8-6-14(7-9-16)17-2-1-3-18-22-20(24-26(17)18)23-19(27)15-4-5-15/h1-3,6-9,13,15H,4-5,11-12H2,(H,23,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM348927 (N-(5-(4- (cyclohexylmethoxy)phenyl)- [1,2,4]triazo...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(OCC4CCCCC4)cc3)n2n1)C1CC1 Show InChI InChI=1S/C23H26N4O2/c28-22(18-9-10-18)25-23-24-21-8-4-7-20(27(21)26-23)17-11-13-19(14-12-17)29-15-16-5-2-1-3-6-16/h4,7-8,11-14,16,18H,1-3,5-6,9-10,15H2,(H,25,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM348935 (N-(5-(4-((3,5- dimethylisoxazol-4- yl)methoxy)phen...) Show SMILES Cc1noc(C)c1COc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C22H21N5O3/c1-13-18(14(2)30-26-13)12-29-17-10-8-15(9-11-17)19-4-3-5-20-23-22(25-27(19)20)24-21(28)16-6-7-16/h3-5,8-11,16H,6-7,12H2,1-2H3,(H,24,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM348944 (N-(5-(4-(1,2,3,4- tetrahydroisoquinoline-2- carbon...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)N3CCc4ccccc4C3)n2n1)C1CC1 Show InChI InChI=1S/C26H23N5O2/c32-24(19-10-11-19)28-26-27-23-7-3-6-22(31(23)29-26)18-8-12-20(13-9-18)25(33)30-15-14-17-4-1-2-5-21(17)16-30/h1-9,12-13,19H,10-11,14-16H2,(H,28,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM348952 (N-(5-(4-(pyridin-3-yl)phenyl)- [1,2,4]triazolo[1,5...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)-c3cccnc3)n2n1)C1CC1 Show InChI InChI=1S/C21H17N5O/c27-20(16-10-11-16)24-21-23-19-5-1-4-18(26(19)25-21)15-8-6-14(7-9-15)17-3-2-12-22-13-17/h1-9,12-13,16H,10-11H2,(H,24,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM348962 (N-(5-(4-(2- phenylethylsulfonamido) phenyl)-[1,2,4...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(NS(=O)(=O)CCc4ccccc4)cc3)n2n1)C1CC1 Show InChI InChI=1S/C24H23N5O3S/c30-23(19-9-10-19)26-24-25-22-8-4-7-21(29(22)27-24)18-11-13-20(14-12-18)28-33(31,32)16-15-17-5-2-1-3-6-17/h1-8,11-14,19,28H,9-10,15-16H2,(H,26,27,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM348971 (N-(5-(4-(2-(3- fluorophenyl)ethylsulfonamido) phen...) Show SMILES Fc1cccc(CCS(=O)(=O)Nc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)c1 Show InChI InChI=1S/C24H22FN5O3S/c25-19-4-1-3-16(15-19)13-14-34(32,33)29-20-11-9-17(10-12-20)21-5-2-6-22-26-24(28-30(21)22)27-23(31)18-7-8-18/h1-6,9-12,15,18,29H,7-8,13-14H2,(H,27,28,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM348981 (N-(5-(4-((1,2,4-oxadiazol-3- yl)methoxy)phenyl)- [...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(OCc4ncon4)cc3)n2n1)C1CC1 Show InChI InChI=1S/C19H16N6O3/c26-18(13-4-5-13)22-19-21-17-3-1-2-15(25(17)23-19)12-6-8-14(9-7-12)27-10-16-20-11-28-24-16/h1-3,6-9,11,13H,4-5,10H2,(H,22,23,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM348899 (N-(5-(4-(benzyloxy)phenyl)- [1,2,4]triazolo[1,5-a]...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(OCc4ccccc4)cc3)n2n1)C1CC1 Show InChI InChI=1S/C23H20N4O2/c28-22(18-9-10-18)25-23-24-21-8-4-7-20(27(21)26-23)17-11-13-19(14-12-17)29-15-16-5-2-1-3-6-16/h1-8,11-14,18H,9-10,15H2,(H,25,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM349050 (N-(5-(4-(4,4- difluoropiperidine-1- carbonyl(pheny...) Show SMILES FC1(F)CCN(CC1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C22H21F2N5O2/c23-22(24)10-12-28(13-11-22)20(31)16-8-4-14(5-9-16)17-2-1-3-18-25-21(27-29(17)18)26-19(30)15-6-7-15/h1-5,8-9,15H,6-7,10-13H2,(H,26,27,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM349158 (Cyclopropanecarboxylic acid {5-[4-(4-methoxy-piper...) Show SMILES COC1CCN(CC1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12 Show InChI InChI=1S/C23H25N5O3/c1-31-18-11-13-27(14-12-18)22(30)17-9-5-15(6-10-17)19-3-2-4-20-24-23(26-28(19)20)25-21(29)16-7-8-16/h2-6,9-10,16,18H,7-8,11-14H2,1H3,(H,25,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM349167 (Cyclopropanecarboxylic acid {5-[4-(isoxazol-3- yla...) Show SMILES O=C(Nc1nc2cccc(-c3ccc(CNc4ccon4)cc3)n2n1)C1CC1 Show InChI InChI=1S/C20H18N6O2/c27-19(15-8-9-15)23-20-22-18-3-1-2-16(26(18)24-20)14-6-4-13(5-7-14)12-21-17-10-11-28-25-17/h1-7,10-11,15H,8-9,12H2,(H,21,25)(H,23,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM349067 (N-(5-(1-(pyridin-3-ylmethyl)- 1H-pyrazol-4-yl)- [1...) Show SMILES O=C(Nc1nc2cccc(-c3cnn(Cc4cccnc4)c3)n2n1)C1CC1 Show InChI InChI=1S/C19H17N7O/c27-18(14-6-7-14)23-19-22-17-5-1-4-16(26(17)24-19)15-10-21-25(12-15)11-13-3-2-8-20-9-13/h1-5,8-10,12,14H,6-7,11H2,(H,23,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM349070 (N-(5-(4-(1-(pyridin-2- yl)ethoxy)phenyl)- [1,2,4]t...) Show SMILES CC(Oc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12)c1ccccn1 Show InChI InChI=1S/C23H21N5O2/c1-15(19-5-2-3-14-24-19)30-18-12-10-16(11-13-18)20-6-4-7-21-25-23(27-28(20)21)26-22(29)17-8-9-17/h2-7,10-15,17H,8-9H2,1H3,(H,26,27,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM349071 (US10206907, Compound 190 | methyl 6-((4-(2- (cyclo...) Show SMILES COC(=O)c1ccc(COc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)nc1 Show InChI InChI=1S/C24H21N5O4/c1-32-23(31)17-7-10-18(25-13-17)14-33-19-11-8-15(9-12-19)20-3-2-4-21-26-24(28-29(20)21)27-22(30)16-5-6-16/h2-4,7-13,16H,5-6,14H2,1H3,(H,27,28,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM349077 (Cyclopropanecarboxylic acid {5-[4-(1-hydroxy-pyrid...) Show SMILES [O-][n+]1cccc(COc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)c1 Show InChI InChI=1S/C22H19N5O3/c28-21(17-6-7-17)24-22-23-20-5-1-4-19(27(20)25-22)16-8-10-18(11-9-16)30-14-15-3-2-12-26(29)13-15/h1-5,8-13,17H,6-7,14H2,(H,24,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM349078 (Cyclopropanecarboxylic acid {5-[4-(6-methyl-pyridi...) Show SMILES Cc1ccc(COc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)cn1 Show InChI InChI=1S/C23H21N5O2/c1-15-5-6-16(13-24-15)14-30-19-11-9-17(10-12-19)20-3-2-4-21-25-23(27-28(20)21)26-22(29)18-7-8-18/h2-6,9-13,18H,7-8,14H2,1H3,(H,26,27,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair

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