Found 128 hits of ic50 data for polymerid = 50001400 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM50559126
(CHEMBL4796410)Show SMILES CC(C)Nc1cc(NC(=O)N2CCCc3cc(CN(C)C(C)=O)c(C=O)nc23)ncc1C#N | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM50559129
(CHEMBL4781882)Show SMILES COCCOc1cc(NC(=O)N2CCCc3cc(Br)c(C=O)nc23)ncc1C#N | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM50604182
(CHEMBL5194425)Show SMILES C[C@@H](Oc1ccc2[nH]nc(Nc3c(F)cc(cc3NC(=O)C=C)N3CCC(CC3)N3CCOCC3)c2c1)c1c(Cl)cncc1Cl |r| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM436197
(US10590109, Compound 15 | US10590109, Compound 20)Show SMILES COCCNc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N Show InChI InChI=1S/C23H28N8O4/c1-29-7-8-31(22(33)14-29)13-16-4-5-21(27-19(16)15-32)30(2)23(34)28-20-10-18(25-6-9-35-3)17(11-24)12-26-20/h4-5,10,12,15H,6-9,13-14H2,1-3H3,(H2,25,26,28,34) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM209349
(US9266883, 148)Show SMILES COCCNc1cc(NC(=O)N2CCCc3cc(CN(C)C(=O)COC)c(C=O)nc23)ncc1C#N Show InChI InChI=1S/C24H29N7O5/c1-30(22(33)15-36-3)13-17-9-16-5-4-7-31(23(16)28-20(17)14-32)24(34)29-21-10-19(26-6-8-35-2)18(11-25)12-27-21/h9-10,12,14H,4-8,13,15H2,1-3H3,(H2,26,27,29,34) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM50559107
(CHEMBL4752511)Show SMILES COCCOc1cc(NC(=O)N2CCCc3cc(CN4CC[C@@H](N(C)C)C4=O)c(C=O)nc23)ncc1C#N |r| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM209336
(US9266883, 101)Show SMILES COCCOc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C=O)nc23)ncc1C#N Show InChI InChI=1S/C25H29N7O5/c1-30-6-7-31(23(34)15-30)14-18-10-17-4-3-5-32(24(17)28-20(18)16-33)25(35)29-22-11-21(37-9-8-36-2)19(12-26)13-27-22/h10-11,13,16H,3-9,14-15H2,1-2H3,(H,27,29,35) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM50559123
(CHEMBL4745780)Show SMILES CCN(Cc1cc2CCCN(C(=O)Nc3cc(NCCOC)c(cn3)C#N)c2nc1C=O)C(C)=O | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM209334
(US9266883, 98)Show SMILES COCCNc1cc(NC(=O)N2CCCc3cc(CN4CCOCC4=O)c(C=O)nc23)ncc1C#N Show InChI InChI=1S/C24H27N7O5/c1-35-7-4-26-19-10-21(27-12-18(19)11-25)29-24(34)31-5-2-3-16-9-17(20(14-32)28-23(16)31)13-30-6-8-36-15-22(30)33/h9-10,12,14H,2-8,13,15H2,1H3,(H2,26,27,29,34) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM50559111
(CHEMBL4791610)Show SMILES COCCOc1cc(NC(=O)N2CCCc3cc(CN(C)C(=O)CN(C)C)c(C=O)nc23)ncc1C#N | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM50559118
(CHEMBL4284069)Show SMILES COc1cc(CCc2cc(NC(=O)c3ccccc3NC(=O)C=C)n[nH]2)cc(OC)c1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as reduction in cell viability incubated for 2 days by cell proliferation assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM50559099
(CHEMBL4758510)Show SMILES COC[C@@H](C)Nc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C=O)nc23)ncc1C#N |r| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM50559117
(CHEMBL4784243)Show SMILES COCCOc1cc(NC(=O)N2CCCc3cc(CN(C)C(C)=O)c(C=O)nc23)ncc1C#N | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM50559108
(CHEMBL4745615)Show SMILES COCCOc1cc(NC(=O)N2CCCc3cc(CN4CC[C@H](N(C)C)C4=O)c(C=O)nc23)ncc1C#N |r| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM50559100
(CHEMBL4787060)Show SMILES COC[C@H](C)Nc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C=O)nc23)ncc1C#N |r| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM50559105
(CHEMBL4754106)Show SMILES COCCOc1cc(NC(=O)N2CCCc3cc(CN4C[C@H](CC4=O)N(C)C)c(C=O)nc23)ncc1C#N |r| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM50559124
(CHEMBL4784921)Show SMILES COCCNc1cc(NC(=O)N2CCCc3cc(CN(C)C(=O)C(C)C)c(C=O)nc23)ncc1C#N | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM50559106
(CHEMBL4786195)Show SMILES COCCOc1cc(NC(=O)N2CCCc3cc(CN4C[C@@H](CC4=O)N(C)C)c(C=O)nc23)ncc1C#N |r| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM50559116
(CHEMBL4764394)Show SMILES CC(C)Oc1cc(NC(=O)N2CCCc3cc(CN4CCCC4=O)c(C=O)nc23)ncc1C#N | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM50559104
(CHEMBL4778828)Show SMILES COCCOc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)C(=O)C4)c(C=O)nc23)ncc1C#N | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM209322
(US9266883, 80)Show SMILES COCCNc1cc(NC(=O)N2CCCc3cc(CO)c(C=O)nc23)ncc1C#N Show InChI InChI=1S/C20H22N6O4/c1-30-6-4-22-16-8-18(23-10-15(16)9-21)25-20(29)26-5-2-3-13-7-14(11-27)17(12-28)24-19(13)26/h7-8,10,12,27H,2-6,11H2,1H3,(H2,22,23,25,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM50559118
(CHEMBL4284069)Show SMILES COc1cc(CCc2cc(NC(=O)c3ccccc3NC(=O)C=C)n[nH]2)cc(OC)c1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM209377
(US9266883, 249)Show SMILES COCCNc1cc(NC(=O)N2CCCc3cc(C4CCOCC4)c(C=O)nc23)ncc1C#N Show InChI InChI=1S/C24H28N6O4/c1-33-10-6-26-20-12-22(27-14-18(20)13-25)29-24(32)30-7-2-3-17-11-19(16-4-8-34-9-5-16)21(15-31)28-23(17)30/h11-12,14-16H,2-10H2,1H3,(H2,26,27,29,32) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM209281
(US9266883, 39)Show SMILES COCCOc1cc(NC(=O)N2CCCc3cc(CO)c(C=O)nc23)ncc1C#N Show InChI InChI=1S/C20H21N5O5/c1-29-5-6-30-17-8-18(22-10-15(17)9-21)24-20(28)25-4-2-3-13-7-14(11-26)16(12-27)23-19(13)25/h7-8,10,12,26H,2-6,11H2,1H3,(H,22,24,28) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM50559128
(CHEMBL4742811)Show SMILES COCCNc1cc(NC(=O)N2CCCc3cc(C(F)F)c(C=O)nc23)ncc1C#N | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM209281
(US9266883, 39)Show SMILES COCCOc1cc(NC(=O)N2CCCc3cc(CO)c(C=O)nc23)ncc1C#N Show InChI InChI=1S/C20H21N5O5/c1-29-5-6-30-17-8-18(22-10-15(17)9-21)24-20(28)25-4-2-3-13-7-14(11-26)16(12-27)23-19(13)25/h7-8,10,12,26H,2-6,11H2,1H3,(H,22,24,28) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as reduction in cell viability incubated for 2 days by cell proliferation assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM50189781
(CHEMBL3828009)Show SMILES C[C@@H](Oc1ccc2[nH]nc(\C=C\c3cnn(CCO)c3)c2c1)c1c(Cl)cncc1Cl |r| Show InChI InChI=1S/C21H19Cl2N5O2/c1-13(21-17(22)10-24-11-18(21)23)30-15-3-5-20-16(8-15)19(26-27-20)4-2-14-9-25-28(12-14)6-7-29/h2-5,8-13,29H,6-7H2,1H3,(H,26,27)/b4-2+/t13-/m1/s1 | PDB
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM50559101
(CHEMBL4789692)Show SMILES COCCOc1cc(NC(=O)N2CCCc3cc(CN4C(=O)CN(C)CC4(C)C)c(C=O)nc23)ncc1C#N | PDB
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TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM209336
(US9266883, 101)Show SMILES COCCOc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C=O)nc23)ncc1C#N Show InChI InChI=1S/C25H29N7O5/c1-30-6-7-31(23(34)15-30)14-18-10-17-4-3-5-32(24(17)28-20(18)16-33)25(35)29-22-11-21(37-9-8-36-2)19(12-26)13-27-22/h10-11,13,16H,3-9,14-15H2,1-2H3,(H,27,29,35) | PDB
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TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as reduction in cell viability incubated for 2 days by cell proliferation assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM50559102
(CHEMBL4781381)Show SMILES COCCOc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)C(C)(C)C4=O)c(C=O)nc23)ncc1C#N | PDB
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| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM209291
(US9266883, 49)Show SMILES OCc1cc2CCCN(C(=O)Nc3cc(O[C@@H]4CCOC4)c(cn3)C#N)c2nc1C=O |r| Show InChI InChI=1S/C21H21N5O5/c22-8-15-9-23-19(7-18(15)31-16-3-5-30-12-16)25-21(29)26-4-1-2-13-6-14(10-27)17(11-28)24-20(13)26/h6-7,9,11,16,27H,1-5,10,12H2,(H,23,25,29)/t16-/m1/s1 | PDB
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| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM209322
(US9266883, 80)Show SMILES COCCNc1cc(NC(=O)N2CCCc3cc(CO)c(C=O)nc23)ncc1C#N Show InChI InChI=1S/C20H22N6O4/c1-30-6-4-22-16-8-18(23-10-15(16)9-21)25-20(29)26-5-2-3-13-7-14(11-27)17(12-28)24-19(13)26/h7-8,10,12,27H,2-6,11H2,1H3,(H2,22,23,25,29) | PDB
Reactome pathway
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UniChem
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| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as reduction in cell viability incubated for 2 days by cell proliferation assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM50559122
(CHEMBL4756889)Show SMILES CC(C)Oc1cc(NC(=O)N2CCCc3cc(CN(C(C)C)C(C)=O)c(C=O)nc23)ncc1C#N | PDB
Reactome pathway
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| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM209292
(US9266883, 50)Show SMILES OCc1cc2CCCN(C(=O)Nc3cc(O[C@H]4CCOC4)c(cn3)C#N)c2nc1C=O |r| Show InChI InChI=1S/C21H21N5O5/c22-8-15-9-23-19(7-18(15)31-16-3-5-30-12-16)25-21(29)26-4-1-2-13-6-14(10-27)17(11-28)24-20(13)26/h6-7,9,11,16,27H,1-5,10,12H2,(H,23,25,29)/t16-/m0/s1 | PDB
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TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM50559112
(CHEMBL4764678)Show SMILES COCCOc1cc(NC(=O)N2CCCc3cc(C4CCN(CC(F)(F)F)CC4)c(C=O)nc23)ncc1C#N | PDB
Reactome pathway
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UniChem
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| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM50559110
(CHEMBL4780066)Show SMILES COCCOc1cc(NC(=O)N2CCCc3cc(CN(CCN(C)C)C(C)=O)c(C=O)nc23)ncc1C#N | PDB
Reactome pathway
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UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM209329
(US9266883, 87)Show SMILES CN(C)CC(C)(O)CNc1cc(NC(=O)N2CCCc3cc(CO)c(C=O)nc23)ncc1C#N Show InChI InChI=1S/C23H29N7O4/c1-23(34,14-29(2)3)13-26-18-8-20(25-10-17(18)9-24)28-22(33)30-6-4-5-15-7-16(11-31)19(12-32)27-21(15)30/h7-8,10,12,31,34H,4-6,11,13-14H2,1-3H3,(H2,25,26,28,33) | PDB
Reactome pathway
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM209305
(US9266883, 63)Show SMILES COCCOc1cc(NC(=O)N2CCCc3cc(C(F)F)c(C=O)nc23)ncc1C#N Show InChI InChI=1S/C20H19F2N5O4/c1-30-5-6-31-16-8-17(24-10-13(16)9-23)26-20(29)27-4-2-3-12-7-14(18(21)22)15(11-28)25-19(12)27/h7-8,10-11,18H,2-6H2,1H3,(H,24,26,29) | PDB
Reactome pathway
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UniChem
| Article
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| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM209265
(US9266883, 23)Show SMILES COCCOc1cc(NC(=O)N2CCCc3ccc(C=O)nc23)ncc1C#N Show InChI InChI=1S/C19H19N5O4/c1-27-7-8-28-16-9-17(21-11-14(16)10-20)23-19(26)24-6-2-3-13-4-5-15(12-25)22-18(13)24/h4-5,9,11-12H,2-3,6-8H2,1H3,(H,21,23,26) | PDB
Reactome pathway
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UniChem
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| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM209384
(US9266883, 257)Show SMILES COCCNc1cc(NC(=O)N2CCCc3cc(-c4ccnn4C)c(C=O)nc23)ncc1C#N Show InChI InChI=1S/C23H24N8O3/c1-30-20(5-6-27-30)17-10-15-4-3-8-31(22(15)28-19(17)14-32)23(33)29-21-11-18(25-7-9-34-2)16(12-24)13-26-21/h5-6,10-11,13-14H,3-4,7-9H2,1-2H3,(H2,25,26,29,33) | PDB
Reactome pathway
KEGG
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| PC cid
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UniChem
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM209265
(US9266883, 23)Show SMILES COCCOc1cc(NC(=O)N2CCCc3ccc(C=O)nc23)ncc1C#N Show InChI InChI=1S/C19H19N5O4/c1-27-7-8-28-16-9-17(21-11-14(16)10-20)23-19(26)24-6-2-3-13-4-5-15(12-25)22-18(13)24/h4-5,9,11-12H,2-3,6-8H2,1H3,(H,21,23,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| PC cid
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UniChem
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard Karls University T£bingen
Curated by ChEMBL
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells |
J Med Chem 62: 5673-5724 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01153
BindingDB Entry DOI: 10.7270/Q2959MWN |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM209268
(US9266883, 26)Show SMILES CC1(O)CCN(CC1)c1cc(NC(=O)N2CCCc3ccc(C=O)nc23)ncc1C#N Show InChI InChI=1S/C22H24N6O3/c1-22(31)6-9-27(10-7-22)18-11-19(24-13-16(18)12-23)26-21(30)28-8-2-3-15-4-5-17(14-29)25-20(15)28/h4-5,11,13-14,31H,2-3,6-10H2,1H3,(H,24,26,30) | PDB
Reactome pathway
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PC sid
UniChem
| Article
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| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as reduction in cell viability incubated for 2 days by cell proliferation assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM50559109
(CHEMBL4777580)Show SMILES COCCOc1cc(NC(=O)N2CCCc3cc(CN(CCN(C)C)S(C)(=O)=O)c(C=O)nc23)ncc1C#N | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM50559125
(CHEMBL4759211)Show SMILES COCCNc1cc(NC(=O)N2CCCc3cc(CN(C)C(C)=O)c(C=O)nc23)ncc1C#N | PDB
Reactome pathway
KEGG
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PC sid
UniChem
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM209380
(US9266883, 252)Show SMILES COCCNc1cc(NC(=O)N2CCCc3cc(-c4cnc(C)s4)c(C=O)nc23)ncc1C#N Show InChI InChI=1S/C23H23N7O3S/c1-14-26-12-20(34-14)17-8-15-4-3-6-30(22(15)28-19(17)13-31)23(32)29-21-9-18(25-5-7-33-2)16(10-24)11-27-21/h8-9,11-13H,3-7H2,1-2H3,(H2,25,27,29,32) | PDB
Reactome pathway
KEGG
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM209305
(US9266883, 63)Show SMILES COCCOc1cc(NC(=O)N2CCCc3cc(C(F)F)c(C=O)nc23)ncc1C#N Show InChI InChI=1S/C20H19F2N5O4/c1-30-5-6-31-16-8-17(24-10-13(16)9-23)26-20(29)27-4-2-3-12-7-14(18(21)22)15(11-28)25-19(12)27/h7-8,10-11,18H,2-6H2,1H3,(H,24,26,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as reduction in cell viability incubated for 2 days by cell proliferation assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM209291
(US9266883, 49)Show SMILES OCc1cc2CCCN(C(=O)Nc3cc(O[C@@H]4CCOC4)c(cn3)C#N)c2nc1C=O |r| Show InChI InChI=1S/C21H21N5O5/c22-8-15-9-23-19(7-18(15)31-16-3-5-30-12-16)25-21(29)26-4-1-2-13-6-14(10-27)17(11-28)24-20(13)26/h6-7,9,11,16,27H,1-5,10,12H2,(H,23,25,29)/t16-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as reduction in cell viability incubated for 2 days by cell proliferation assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM209265
(US9266883, 23)Show SMILES COCCOc1cc(NC(=O)N2CCCc3ccc(C=O)nc23)ncc1C#N Show InChI InChI=1S/C19H19N5O4/c1-27-7-8-28-16-9-17(21-11-14(16)10-20)23-19(26)24-6-2-3-13-4-5-15(12-25)22-18(13)24/h4-5,9,11-12H,2-3,6-8H2,1H3,(H,21,23,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as reduction in cell viability incubated for 2 days by cell proliferation assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM50559121
(CHEMBL4758832)Show SMILES CC(C)Oc1cc(NC(=O)N2CCCc3cc(CN(C)S(C)(=O)=O)c(C=O)nc23)ncc1C#N | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Mus musculus) | BDBM50559113
(CHEMBL4744460)Show SMILES COCCOc1cc(NC(=O)N2CCCc3cc(C4CCN(CC4)C4COC4)c(C=O)nc23)ncc1C#N | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01019
BindingDB Entry DOI: 10.7270/Q2FB56MJ |
More data for this
Ligand-Target Pair | |
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