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Patent code US8969341

Compile Data Set for Download or QSAR

Found 345 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143336
PNG
(US8969341, 4)
Show SMILES CC(C)CCn1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cccc(Cl)c1F
Show InChI InChI=1S/C26H28Cl2FN3O/c1-14(2)11-12-31-24(15(3)4)21-23(30-31)26(33)32(20-8-6-7-19(28)22(20)29)25(21)18-10-9-17(27)13-16(18)5/h6-10,13-15,25H,11-12H2,1-5H3
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n/an/a 8.80n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143364
PNG
(US8969341, 24)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CC(=O)N1CCN(C)C(=O)C1)c1cc(Cl)ccc1C)c1ccc(Cl)cc1C
Show InChI InChI=1S/C29H31Cl2N5O3/c1-16(2)27-25-26(32-35(27)15-24(38)34-11-10-33(5)23(37)14-34)29(39)36(22-13-20(31)7-6-17(22)3)28(25)21-9-8-19(30)12-18(21)4/h6-9,12-13,16,28H,10-11,14-15H2,1-5H3
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n/an/a 3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143392
PNG
(US8969341, 43)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CC(=O)N1CCCC1)c1cc(Cl)ccc1C)c1ccc(Cl)cc1C
Show InChI InChI=1S/C28H30Cl2N4O2/c1-16(2)26-24-25(31-33(26)15-23(35)32-11-5-6-12-32)28(36)34(22-14-20(30)8-7-17(22)3)27(24)21-10-9-19(29)13-18(21)4/h7-10,13-14,16,27H,5-6,11-12,15H2,1-4H3
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n/an/a 2n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143406
PNG
(US8969341, 55)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1Cc1ccccc1)c1cccc(Cl)c1F)c1ccc(Cl)cc1C
Show InChI InChI=1S/C28H24Cl2FN3O/c1-16(2)26-23-25(32-33(26)15-18-8-5-4-6-9-18)28(35)34(22-11-7-10-21(30)24(22)31)27(23)20-13-12-19(29)14-17(20)3/h4-14,16,27H,15H2,1-3H3
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n/an/a 24.2n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143419
PNG
(US8969341, 68)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1-c1ccncc1)c1cccc(Cl)c1F)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H19Cl2FN4O/c1-14(2)23-20-22(30-32(23)17-10-12-29-13-11-17)25(33)31(19-5-3-4-18(27)21(19)28)24(20)15-6-8-16(26)9-7-15/h3-14,24H,1-2H3
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n/an/a 108n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143425
PNG
(US8969341, 74)
Show SMILES COc1ccccc1-n1nc2C(=O)N(c3cccc(Cl)c3F)C(CC(=O)N3CCOCC3)(c2c1C(C)C)c1ccc(Cl)cc1
Show InChI InChI=1S/C33H31Cl2FN4O4/c1-20(2)31-28-30(37-40(31)24-8-4-5-10-26(24)43-3)32(42)39(25-9-6-7-23(35)29(25)36)33(28,21-11-13-22(34)14-12-21)19-27(41)38-15-17-44-18-16-38/h4-14,20H,15-19H2,1-3H3
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n/an/a 7.10n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143439
PNG
(US8969341, 87)
Show SMILES COc1ccccc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)c(F)cc1F
Show InChI InChI=1S/C28H23Cl2F2N3O2/c1-14(2)26-24-25(33-35(26)21-7-5-6-8-23(21)37-4)28(36)34(22-12-18(30)19(31)13-20(22)32)27(24)17-10-9-16(29)11-15(17)3/h5-14,27H,1-4H3
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n/an/a 1.90n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143441
PNG
(US8969341, 89)
Show SMILES COC(=O)CCC1(N(C(=O)c2nn(c(C(C)C)c12)-c1ccccc1OC)c1ccc(F)c(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C31H28Cl2FN3O4/c1-18(2)29-27-28(35-37(29)24-7-5-6-8-25(24)40-3)30(39)36(21-13-14-23(34)22(33)17-21)31(27,16-15-26(38)41-4)19-9-11-20(32)12-10-19/h5-14,17-18H,15-16H2,1-4H3
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n/an/a 1.10n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143453
PNG
(US8969341, 98)
Show SMILES COc1ccccc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cn1)c1cc(Cl)ccc1C
Show InChI InChI=1S/C27H24Cl2N4O2/c1-15(2)25-23-24(31-33(25)20-7-5-6-8-22(20)35-4)27(34)32(21-13-17(28)10-9-16(21)3)26(23)19-12-11-18(29)14-30-19/h5-15,26H,1-4H3
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n/an/a 1.90n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143464
PNG
(US8969341, 105)
Show SMILES COc1ccccc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)cc(NC(C)=O)c1
Show InChI InChI=1S/C30H28Cl2N4O3/c1-16(2)28-26-27(34-36(28)24-8-6-7-9-25(24)39-5)30(38)35(29(26)23-11-10-19(31)12-17(23)3)22-14-20(32)13-21(15-22)33-18(4)37/h6-16,29H,1-5H3,(H,33,37)
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n/an/a 2.90n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143466
PNG
(US8969341, 107)
Show SMILES COc1ccccc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C27H22ClF2N3O2/c1-15(2)25-23-24(31-33(25)21-6-4-5-7-22(21)35-3)27(34)32(18-12-13-19(29)20(30)14-18)26(23)16-8-10-17(28)11-9-16/h4-15,26H,1-3H3
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n/an/a 1.70n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143669
PNG
(US8969341, 176)
Show SMILES COc1ncc(c(OC)n1)-n1nc2C(=O)N([C@H](c2c1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)c(=O)n(C)c1 |r|
Show InChI InChI=1S/C26H24Cl2N6O4/c1-13(2)21-19-20(31-34(21)18-11-29-26(38-5)30-23(18)37-4)25(36)33(16-10-17(28)24(35)32(3)12-16)22(19)14-6-8-15(27)9-7-14/h6-13,22H,1-5H3/t22-/m0/s1
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n/an/a 0.700n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143333
PNG
(US8969341, 1)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1Cc1ccccn1)c1cccc(Cl)c1F)c1ccc(Cl)cc1C
Show InChI InChI=1S/C27H23Cl2FN4O/c1-15(2)25-22-24(32-33(25)14-18-7-4-5-12-31-18)27(35)34(21-9-6-8-20(29)23(21)30)26(22)19-11-10-17(28)13-16(19)3/h4-13,15,26H,14H2,1-3H3
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n/an/a 4.16E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143389
PNG
(US8969341, 41)
Show SMILES CC(C)CCn1nc2C(=O)N(C(c2c1C1CC1)c1ccc(Cl)cc1C)c1cccc(Cl)c1F
Show InChI InChI=1S/C26H26Cl2FN3O/c1-14(2)11-12-31-24(16-7-8-16)21-23(30-31)26(33)32(20-6-4-5-19(28)22(20)29)25(21)18-10-9-17(27)13-15(18)3/h4-6,9-10,13-14,16,25H,7-8,11-12H2,1-3H3
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n/an/a 4.69E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143396
PNG
(US8969341, 47)
Show SMILES CCn1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1OCCN(C)C
Show InChI InChI=1S/C27H32Cl2N4O2/c1-7-32-25(16(2)3)23-24(30-32)27(34)33(26(23)20-10-8-18(28)14-17(20)4)21-15-19(29)9-11-22(21)35-13-12-31(5)6/h8-11,14-16,26H,7,12-13H2,1-6H3
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n/an/a 2.09E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143421
PNG
(US8969341, 70)
Show SMILES COc1ccccc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1)c1cccc(Cl)c1F
Show InChI InChI=1S/C27H22Cl2FN3O2/c1-15(2)25-22-24(31-33(25)19-8-4-5-10-21(19)35-3)27(34)32(20-9-6-7-18(29)23(20)30)26(22)16-11-13-17(28)14-12-16/h4-15,26H,1-3H3
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n/an/a 1.24E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143424
PNG
(US8969341, 73)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1C1CCOCC1)c1cccc(Cl)c1F)c1ccc(Cl)cc1C
Show InChI InChI=1S/C26H26Cl2FN3O2/c1-14(2)24-21-23(30-32(24)17-9-11-34-12-10-17)26(33)31(20-6-4-5-19(28)22(20)29)25(21)18-8-7-16(27)13-15(18)3/h4-8,13-14,17,25H,9-12H2,1-3H3
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n/an/a 2.05E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143429
PNG
(US8969341, 78)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CCC#N)c1cccc(Cl)c1F)c1ccc(Cl)cc1C
Show InChI InChI=1S/C24H21Cl2FN4O/c1-13(2)22-19-21(29-30(22)11-5-10-28)24(32)31(18-7-4-6-17(26)20(18)27)23(19)16-9-8-15(25)12-14(16)3/h4,6-9,12-13,23H,5,11H2,1-3H3
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n/an/a 2.78E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143431
PNG
(US8969341, 80)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1-c1ccc(cc1C)C#N)c1cccc(Cl)c1F)c1ccc(Cl)cc1C
Show InChI InChI=1S/C29H23Cl2FN4O/c1-15(2)27-24-26(34-36(27)22-11-8-18(14-33)12-17(22)4)29(37)35(23-7-5-6-21(31)25(23)32)28(24)20-10-9-19(30)13-16(20)3/h5-13,15,28H,1-4H3
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n/an/a 2.12E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143441
PNG
(US8969341, 89)
Show SMILES COC(=O)CCC1(N(C(=O)c2nn(c(C(C)C)c12)-c1ccccc1OC)c1ccc(F)c(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C31H28Cl2FN3O4/c1-18(2)29-27-28(35-37(29)24-7-5-6-8-25(24)40-3)30(39)36(21-13-14-23(34)22(33)17-21)31(27,16-15-26(38)41-4)19-9-11-20(32)12-10-19/h5-14,17-18H,15-16H2,1-4H3
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n/an/a 2.42E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143447
PNG
(US8969341, 95)
Show SMILES COc1ccccc1-n1nc2C(=O)N(c3ccc(F)c(Cl)c3)C(CC(O)CN3CCCC3)(c2c1C(C)C)c1ccc(Cl)cc1
Show InChI InChI=1S/C34H35Cl2FN4O3/c1-21(2)32-30-31(38-41(32)28-8-4-5-9-29(28)44-3)33(43)40(24-14-15-27(37)26(36)18-24)34(30,22-10-12-23(35)13-11-22)19-25(42)20-39-16-6-7-17-39/h4-5,8-15,18,21,25,42H,6-7,16-17,19-20H2,1-3H3
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n/an/a 3.20E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143452
PNG
(US8969341, 97)
Show SMILES COc1ccccc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cn1)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C26H21Cl2FN4O2/c1-14(2)24-22-23(31-33(24)20-6-4-5-7-21(20)35-3)26(34)32(16-9-10-18(29)17(28)12-16)25(22)19-11-8-15(27)13-30-19/h4-14,25H,1-3H3
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n/an/a 3.53E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143453
PNG
(US8969341, 98)
Show SMILES COc1ccccc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cn1)c1cc(Cl)ccc1C
Show InChI InChI=1S/C27H24Cl2N4O2/c1-15(2)25-23-24(31-33(25)20-7-5-6-8-22(20)35-4)27(34)32(21-13-17(28)10-9-16(21)3)26(23)19-12-11-18(29)14-30-19/h5-15,26H,1-4H3
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n/an/a 3.26E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143463
PNG
(US8969341, 104)
Show SMILES COc1ccccc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)cc(c1)C(N)=O
Show InChI InChI=1S/C29H26Cl2N4O3/c1-15(2)26-24-25(33-35(26)22-7-5-6-8-23(22)38-4)29(37)34(20-13-17(28(32)36)12-19(31)14-20)27(24)21-10-9-18(30)11-16(21)3/h5-15,27H,1-4H3,(H2,32,36)
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n/an/a 1.16E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143507
PNG
(US8969341, 125)
Show SMILES COc1ccc(cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C)C#N
Show InChI InChI=1S/C30H26Cl2N4O2/c1-16(2)28-26-27(34-36(28)24-13-19(15-33)7-11-25(24)38-5)30(37)35(23-14-21(32)8-6-17(23)3)29(26)22-10-9-20(31)12-18(22)4/h6-14,16,29H,1-5H3
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n/an/a 0.187n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143513
PNG
(US8969341, 128)
Show SMILES COc1ccc(CNC=O)cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C
Show InChI InChI=1S/C31H30Cl2N4O3/c1-17(2)29-27-28(35-37(29)25-13-20(15-34-16-38)7-11-26(25)40-5)31(39)36(24-14-22(33)8-6-18(24)3)30(27)23-10-9-21(32)12-19(23)4/h6-14,16-17,30H,15H2,1-5H3,(H,34,38)
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n/an/a 0.169n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143514
PNG
(US8969341, 129)
Show SMILES COc1ccc(cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)c(=O)n(C)c1)C#N
Show InChI InChI=1S/C29H25Cl2N5O3/c1-15(2)26-24-25(33-36(26)22-11-17(13-32)6-9-23(22)39-5)29(38)35(19-12-21(31)28(37)34(4)14-19)27(24)20-8-7-18(30)10-16(20)3/h6-12,14-15,27H,1-5H3
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n/an/a 0.382n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143530
PNG
(US8969341, 135)
Show SMILES COc1cnc(cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)c(=O)n(C)c1)C#N
Show InChI InChI=1S/C28H24Cl2N6O3/c1-14(2)25-23-24(33-36(25)21-9-17(11-31)32-12-22(21)39-5)28(38)35(18-10-20(30)27(37)34(4)13-18)26(23)19-7-6-16(29)8-15(19)3/h6-10,12-14,26H,1-5H3
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n/an/a 0.75n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143546
PNG
(US8969341, 141)
Show SMILES COc1ccccc1-n1nc2C(=O)N([C@H](c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C |r|
Show InChI InChI=1S/C29H27Cl2N3O2/c1-16(2)27-25-26(32-34(27)22-8-6-7-9-24(22)36-5)29(35)33(23-15-20(31)11-10-17(23)3)28(25)21-13-12-19(30)14-18(21)4/h6-16,28H,1-5H3/t28-/m0/s1
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n/an/a 0.161n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143581
PNG
(US8969341, 151)
Show SMILES COc1nc(ncc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(cc1)C#N)c1cc(Cl)cn(C)c1=O)N(C)C
Show InChI InChI=1S/C28H27ClN8O3/c1-15(2)23-21-22(33-37(23)20-13-31-28(34(3)4)32-25(20)40-6)27(39)36(19-11-18(29)14-35(5)26(19)38)24(21)17-9-7-16(12-30)8-10-17/h7-11,13-15,24H,1-6H3
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n/an/a 0.370n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143615
PNG
(US8969341, 160)
Show SMILES COc1ncc(c(OC)n1)-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(cc1)C#N)c1cc(Cl)c[nH]c1=O
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n/an/a 1.24n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143430
PNG
(US8969341, 79)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CCO)c1ccc(F)c(Cl)c1)c1ccc(Cl)cc1C
Show InChI InChI=1S/C23H22Cl2FN3O2/c1-12(2)21-19-20(27-28(21)8-9-30)23(31)29(15-5-7-18(26)17(25)11-15)22(19)16-6-4-14(24)10-13(16)3/h4-7,10-12,22,30H,8-9H2,1-3H3
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n/an/a 4.10n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143340
PNG
(US8969341, 8)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CCc1ccccn1)c1cccc(Cl)c1F)c1ccc(Cl)cc1C
Show InChI InChI=1S/C28H25Cl2FN4O/c1-16(2)26-23-25(33-34(26)14-12-19-7-4-5-13-32-19)28(36)35(22-9-6-8-21(30)24(22)31)27(23)20-11-10-18(29)15-17(20)3/h4-11,13,15-16,27H,12,14H2,1-3H3
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n/an/a 9.90n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143349
PNG
(US8969341, 17)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1Cc1ncc[nH]1)c1cccc(Cl)c1F)c1ccc(Cl)cc1
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n/an/a 33.9n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143357
PNG
(US8969341, 21)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CC(=O)NC1CCN(CC1)C(C)=O)c1cc(Cl)ccc1C)c1ccc(Cl)cc1C
Show InChI InChI=1S/C31H35Cl2N5O3/c1-17(2)29-27-28(35-37(29)16-26(40)34-23-10-12-36(13-11-23)20(5)39)31(41)38(25-15-22(33)7-6-18(25)3)30(27)24-9-8-21(32)14-19(24)4/h6-9,14-15,17,23,30H,10-13,16H2,1-5H3,(H,34,40)
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n/an/a 2.80n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143380
PNG
(US8969341, 34)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1Cc1csc(C)n1)c1cccc(Cl)c1F)c1ccc(Cl)cc1C
Show InChI InChI=1S/C26H23Cl2FN4OS/c1-13(2)24-21-23(31-32(24)11-17-12-35-15(4)30-17)26(34)33(20-7-5-6-19(28)22(20)29)25(21)18-9-8-16(27)10-14(18)3/h5-10,12-13,25H,11H2,1-4H3
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n/an/a 6.20n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143408
PNG
(US8969341, 57)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CCO)c1cccc(Cl)c1F)c1ccc(Cl)cc1C
Show InChI InChI=1S/C23H22Cl2FN3O2/c1-12(2)21-18-20(27-28(21)9-10-30)23(31)29(17-6-4-5-16(25)19(17)26)22(18)15-8-7-14(24)11-13(15)3/h4-8,11-12,22,30H,9-10H2,1-3H3
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n/an/a 5.90n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143431
PNG
(US8969341, 80)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1-c1ccc(cc1C)C#N)c1cccc(Cl)c1F)c1ccc(Cl)cc1C
Show InChI InChI=1S/C29H23Cl2FN4O/c1-15(2)27-24-26(34-36(27)22-11-8-18(14-33)12-17(22)4)29(37)35(23-7-5-6-21(31)25(23)32)28(24)20-10-9-19(30)13-16(20)3/h5-13,15,28H,1-4H3
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n/an/a 3.20n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143442
PNG
(US8969341, 90)
Show SMILES CCOC(=O)C1(N(C(=O)c2nn(c(C(C)C)c12)-c1ccccc1OC)c1ccc(F)c(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C30H26Cl2FN3O4/c1-5-40-29(38)30(18-10-12-19(31)13-11-18)25-26(28(37)35(30)20-14-15-22(33)21(32)16-20)34-36(27(25)17(2)3)23-8-6-7-9-24(23)39-4/h6-17H,5H2,1-4H3
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n/an/a 5.20n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143457
PNG
(US8969341, 101)
Show SMILES CNC(=O)c1ccc(OC)c(c1)-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C
Show InChI InChI=1S/C31H30Cl2N4O3/c1-16(2)28-26-27(35-37(28)24-14-19(30(38)34-5)8-12-25(24)40-6)31(39)36(23-15-21(33)9-7-17(23)3)29(26)22-11-10-20(32)13-18(22)4/h7-16,29H,1-6H3,(H,34,38)
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n/an/a 2n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143479
PNG
(US8969341, 117a | US8969341, 117b)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1C1CCC(O)CC1)c1cccc(Cl)c1F)c1ccc(Cl)cc1C |(1.6,-3.66,;.26,-2.89,;-1.07,-3.66,;.26,-1.35,;-.98,-.44,;-2.52,-.44,;-3,1.02,;-1.75,1.93,;-1.75,3.47,;-.51,1.02,;1.03,1.02,;1.51,-.44,;3,-.84,;3.4,-2.33,;4.88,-2.73,;5.97,-1.64,;7.46,-2.03,;5.57,-.15,;4.09,.25,;-4.49,1.42,;-5.57,.33,;-7.06,.73,;-7.46,2.22,;-6.37,3.31,;-6.77,4.8,;-4.88,2.91,;-3.79,4,;-3.61,-1.53,;-3.21,-3.02,;-4.3,-4.11,;-5.79,-3.71,;-6.88,-4.8,;-6.19,-2.22,;-5.1,-1.13,;-5.87,.2,)|
Show InChI InChI=1S/C27H28Cl2FN3O2/c1-14(2)25-22-24(31-33(25)17-8-10-18(34)11-9-17)27(35)32(21-6-4-5-20(29)23(21)30)26(22)19-12-7-16(28)13-15(19)3/h4-7,12-14,17-18,26,34H,8-11H2,1-3H3
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n/an/a 22.5n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143480
PNG
(US8969341, 118)
Show SMILES COc1ccccc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1ccnc(Cl)c1
Show InChI InChI=1S/C27H24Cl2N4O2/c1-15(2)25-23-24(31-33(25)20-7-5-6-8-21(20)35-4)27(34)32(18-11-12-30-22(29)14-18)26(23)19-10-9-17(28)13-16(19)3/h5-15,26H,1-4H3
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n/an/a 7.20n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143496
PNG
(US8969341, 122)
Show SMILES COc1ccncc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C
Show InChI InChI=1S/C28H26Cl2N4O2/c1-15(2)26-24-25(32-34(26)22-14-31-11-10-23(22)36-5)28(35)33(21-13-19(30)7-6-16(21)3)27(24)20-9-8-18(29)12-17(20)4/h6-15,27H,1-5H3
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n/an/a 2.5n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143499
PNG
(US8969341, 124)
Show SMILES COc1ccccc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)ccc1OCc1nn[nH]n1
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n/an/a 1.80n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143507
PNG
(US8969341, 125)
Show SMILES COc1ccc(cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C)C#N
Show InChI InChI=1S/C30H26Cl2N4O2/c1-16(2)28-26-27(34-36(28)24-13-19(15-33)7-11-25(24)38-5)30(37)35(23-14-21(32)8-6-17(23)3)29(26)22-10-9-20(31)12-18(22)4/h6-14,16,29H,1-5H3
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n/an/a 1.70n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143336
PNG
(US8969341, 4)
Show SMILES CC(C)CCn1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cccc(Cl)c1F
Show InChI InChI=1S/C26H28Cl2FN3O/c1-14(2)11-12-31-24(15(3)4)21-23(30-31)26(33)32(20-8-6-7-19(28)22(20)29)25(21)18-10-9-17(27)13-16(18)5/h6-10,13-15,25H,11-12H2,1-5H3
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n/an/a 3.51E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143340
PNG
(US8969341, 8)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CCc1ccccn1)c1cccc(Cl)c1F)c1ccc(Cl)cc1C
Show InChI InChI=1S/C28H25Cl2FN4O/c1-16(2)26-23-25(33-34(26)14-12-19-7-4-5-13-32-19)28(36)35(22-9-6-8-21(30)24(22)31)27(23)20-11-10-18(29)15-17(20)3/h4-11,13,15-16,27H,12,14H2,1-3H3
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n/an/a 1.97E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143341
PNG
(US8969341, 9)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CCc1c[nH]c2ccccc12)c1cccc(Cl)c1F)c1ccc(Cl)cc1C
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n/an/a 5.12E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143348
PNG
(US8969341, 16)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1Cc1cc(C)nn1C)c1cccc(Cl)c1F)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H24Cl2FN5O/c1-14(2)24-21-23(31-33(24)13-18-12-15(3)30-32(18)4)26(35)34(20-7-5-6-19(28)22(20)29)25(21)16-8-10-17(27)11-9-16/h5-12,14,25H,13H2,1-4H3
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n/an/a 1.59E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143353
PNG
(US8969341, 19)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CC(=O)N1CCC(O)CC1)c1cc(Cl)ccc1C)c1ccc(Cl)cc1C
Show InChI InChI=1S/C29H32Cl2N4O3/c1-16(2)27-25-26(32-34(27)15-24(37)33-11-9-21(36)10-12-33)29(38)35(23-14-20(31)6-5-17(23)3)28(25)22-8-7-19(30)13-18(22)4/h5-8,13-14,16,21,28,36H,9-12,15H2,1-4H3
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n/an/a 3.67E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%