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Patent code US8969341

Compile Data Set for Download or QSAR

Found 345 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143339
PNG
(US8969341, 7)
Show SMILES [#6]-[#6](-[#6])-c1c2-[#6](-[#7](-[#6](=O)-c2nn1-[#6]\[#6]=[#6](\[#6])-[#6])-c1cccc(Cl)c1F)-c1ccc(Cl)cc1-[#6]
Show InChI InChI=1S/C26H26Cl2FN3O/c1-14(2)11-12-31-24(15(3)4)21-23(30-31)26(33)32(20-8-6-7-19(28)22(20)29)25(21)18-10-9-17(27)13-16(18)5/h6-11,13,15,25H,12H2,1-5H3
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n/an/a 4.80n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143345
PNG
(US8969341, 13)
Show SMILES CCN1CCN(CCn2nc3C(=O)N(C(c3c2C(C)C)c2ccc(Cl)cc2)c2cccc(Cl)c2F)C1=O
Show InChI InChI=1S/C27H28Cl2FN5O2/c1-4-32-12-13-33(27(32)37)14-15-34-24(16(2)3)21-23(31-34)26(36)35(20-7-5-6-19(29)22(20)30)25(21)17-8-10-18(28)11-9-17/h5-11,16,25H,4,12-15H2,1-3H3
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n/an/a 8.90n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143348
PNG
(US8969341, 16)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1Cc1cc(C)nn1C)c1cccc(Cl)c1F)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H24Cl2FN5O/c1-14(2)24-21-23(31-33(24)13-18-12-15(3)30-32(18)4)26(35)34(20-7-5-6-19(28)22(20)29)25(21)16-8-10-17(27)11-9-16/h5-12,14,25H,13H2,1-4H3
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n/an/a 7.90n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143364
PNG
(US8969341, 24)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CC(=O)N1CCN(C)C(=O)C1)c1cc(Cl)ccc1C)c1ccc(Cl)cc1C
Show InChI InChI=1S/C29H31Cl2N5O3/c1-16(2)27-25-26(32-35(27)15-24(38)34-11-10-33(5)23(37)14-34)29(39)36(22-13-20(31)7-6-17(22)3)28(25)21-9-8-19(30)12-18(21)4/h6-9,12-13,16,28H,10-11,14-15H2,1-5H3
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n/an/a 3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143410
PNG
(US8969341, 59)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1-c1ccccc1F)c1cccc(Cl)c1F)c1ccc(Cl)cc1C
Show InChI InChI=1S/C27H21Cl2F2N3O/c1-14(2)25-22-24(32-34(25)20-9-5-4-8-19(20)30)27(35)33(21-10-6-7-18(29)23(21)31)26(22)17-12-11-16(28)13-15(17)3/h4-14,26H,1-3H3
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n/an/a 7.30n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143412
PNG
(US8969341, 61)
Show SMILES CNS(=O)(=O)Cc1ccc(cc1)-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cccc(Cl)c1F
Show InChI InChI=1S/C29H27Cl2FN4O3S/c1-16(2)27-24-26(34-36(27)20-11-8-18(9-12-20)15-40(38,39)33-4)29(37)35(23-7-5-6-22(31)25(23)32)28(24)21-13-10-19(30)14-17(21)3/h5-14,16,28,33H,15H2,1-4H3
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n/an/a 6.80n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143416
PNG
(US8969341, 65)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CCO)c1cccc(Cl)c1F)c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C22H19Cl2F2N3O2/c1-11(2)20-17-19(27-28(20)8-9-30)22(31)29(16-5-3-4-14(24)18(16)26)21(17)12-6-7-13(23)15(25)10-12/h3-7,10-11,21,30H,8-9H2,1-2H3
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n/an/a 7.80n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143419
PNG
(US8969341, 68)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1-c1ccncc1)c1cccc(Cl)c1F)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H19Cl2FN4O/c1-14(2)23-20-22(30-32(23)17-10-12-29-13-11-17)25(33)31(19-5-3-4-18(27)21(19)28)24(20)15-6-8-16(26)9-7-15/h3-14,24H,1-2H3
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n/an/a 108n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143443
PNG
(US8969341, 91)
Show SMILES COc1ccccc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cncc(Cl)c1
Show InChI InChI=1S/C27H24Cl2N4O2/c1-15(2)25-23-24(31-33(25)21-7-5-6-8-22(21)35-4)27(34)32(19-12-18(29)13-30-14-19)26(23)20-10-9-17(28)11-16(20)3/h5-15,26H,1-4H3
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n/an/a 83.3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143462
PNG
(US8969341, 103)
Show SMILES COc1ccccc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)cc(c1)[N+]#[C-]
Show InChI InChI=1S/C29H24Cl2N4O2/c1-16(2)27-25-26(33-35(27)23-8-6-7-9-24(23)37-5)29(36)34(21-14-19(31)13-20(15-21)32-4)28(25)22-11-10-18(30)12-17(22)3/h6-16,28H,1-3,5H3
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n/an/a 3.80n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143493
PNG
(US8969341, 121)
Show SMILES COc1ccncc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1)c1cccc(Cl)c1F
Show InChI InChI=1S/C26H21Cl2FN4O2/c1-14(2)24-21-23(31-33(24)19-13-30-12-11-20(19)35-3)26(34)32(18-6-4-5-17(28)22(18)29)25(21)15-7-9-16(27)10-8-15/h4-14,25H,1-3H3
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n/an/a 6.90n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143545
PNG
(US8969341, 140)
Show SMILES CC(C)c1c2[C@H](N(C(=O)c2nn1CCO)c1cccc(Cl)c1F)c1ccc(Cl)cc1C |r|
Show InChI InChI=1S/C23H22Cl2FN3O2/c1-12(2)21-18-20(27-28(21)9-10-30)23(31)29(17-6-4-5-16(25)19(17)26)22(18)15-8-7-14(24)11-13(15)3/h4-8,11-12,22,30H,9-10H2,1-3H3/t22-/m1/s1
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n/an/a 2.09E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143548
PNG
(US8969341, 143)
Show SMILES COc1ccccc1-n1nc2C(=O)N([C@H](c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1OCCN(C)C |r|
Show InChI InChI=1S/C32H34Cl2N4O3/c1-19(2)30-28-29(35-38(30)24-9-7-8-10-26(24)40-6)32(39)37(31(28)23-13-11-21(33)17-20(23)3)25-18-22(34)12-14-27(25)41-16-15-36(4)5/h7-14,17-19,31H,15-16H2,1-6H3/t31-/m0/s1
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n/an/a 0.5n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Protein Mdm4


(Homo sapiens (Human))		BDBM143365
PNG
(US8969341, 25)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CC1CCN(CC1)C(C)=O)c1cc(Cl)ccc1C)c1ccc(Cl)cc1C
Show InChI InChI=1S/C30H34Cl2N4O2/c1-17(2)28-26-27(33-35(28)16-21-10-12-34(13-11-21)20(5)37)30(38)36(25-15-23(32)7-6-18(25)3)29(26)24-9-8-22(31)14-19(24)4/h6-9,14-15,17,21,29H,10-13,16H2,1-5H3
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n/an/a 6.65E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143380
PNG
(US8969341, 34)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1Cc1csc(C)n1)c1cccc(Cl)c1F)c1ccc(Cl)cc1C
Show InChI InChI=1S/C26H23Cl2FN4OS/c1-13(2)24-21-23(31-32(24)11-17-12-35-15(4)30-17)26(34)33(20-7-5-6-19(28)22(20)29)25(21)18-9-8-16(27)10-14(18)3/h5-10,12-13,25H,11H2,1-4H3
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n/an/a 1.35E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143383
PNG
(US8969341, 37)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1Cc1cscn1)c1cccc(Cl)c1F)c1ccc(Cl)cc1C
Show InChI InChI=1S/C25H21Cl2FN4OS/c1-13(2)23-20-22(30-31(23)10-16-11-34-12-29-16)25(33)32(19-6-4-5-18(27)21(19)28)24(20)17-8-7-15(26)9-14(17)3/h4-9,11-13,24H,10H2,1-3H3
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n/an/a 2.10E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143400
PNG
(US8969341, 51)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1C(=O)N(C)c1ccccc1)c1cc(Cl)ccc1C)c1ccc(Cl)cc1C
Show InChI InChI=1S/C30H28Cl2N4O2/c1-17(2)27-25-26(33-36(27)30(38)34(5)22-9-7-6-8-10-22)29(37)35(24-16-21(32)12-11-18(24)3)28(25)23-14-13-20(31)15-19(23)4/h6-17,28H,1-5H3
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n/an/a 4.07E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143401
PNG
(US8969341, 52)
Show SMILES COC(=O)N1CCCC1Cn1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C
Show InChI InChI=1S/C29H32Cl2N4O3/c1-16(2)26-24-25(32-34(26)15-21-7-6-12-33(21)29(37)38-5)28(36)35(23-14-20(31)9-8-17(23)3)27(24)22-11-10-19(30)13-18(22)4/h8-11,13-14,16,21,27H,6-7,12,15H2,1-5H3
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n/an/a 5.63E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143411
PNG
(US8969341, 60)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CCO)c1cccc(Cl)c1F)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C22H19Cl3FN3O2/c1-11(2)20-17-19(27-28(20)8-9-30)22(31)29(16-5-3-4-14(24)18(16)26)21(17)13-7-6-12(23)10-15(13)25/h3-7,10-11,21,30H,8-9H2,1-2H3
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n/an/a 2.03E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143441
PNG
(US8969341, 89)
Show SMILES COC(=O)CCC1(N(C(=O)c2nn(c(C(C)C)c12)-c1ccccc1OC)c1ccc(F)c(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C31H28Cl2FN3O4/c1-18(2)29-27-28(35-37(29)24-7-5-6-8-25(24)40-3)30(39)36(21-13-14-23(34)22(33)17-21)31(27,16-15-26(38)41-4)19-9-11-20(32)12-10-19/h5-14,17-18H,15-16H2,1-4H3
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n/an/a 2.42E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143450
PNG
(US8969341, 96)
Show SMILES CNC(=O)c1ccc(C)c(c1)-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(cc1)C(F)(F)F)c1cc(Cl)ccc1C
Show InChI InChI=1S/C31H28ClF3N4O2/c1-16(2)27-25-26(37-39(27)24-14-20(29(40)36-5)8-6-18(24)4)30(41)38(23-15-22(32)13-7-17(23)3)28(25)19-9-11-21(12-10-19)31(33,34)35/h6-16,28H,1-5H3,(H,36,40)
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n/an/a 1.29E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143477
PNG
(US8969341, 115)
Show SMILES COc1ccccc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)c(=O)n(CCN(C)C)c1
Show InChI InChI=1S/C30H31Cl2N5O3/c1-18(2)27-25-26(33-37(27)23-8-6-7-9-24(23)40-5)30(39)36(28(25)19-10-12-20(31)13-11-19)21-16-22(32)29(38)35(17-21)15-14-34(3)4/h6-13,16-18,28H,14-15H2,1-5H3
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n/an/a 5.78E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143507
PNG
(US8969341, 125)
Show SMILES COc1ccc(cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C)C#N
Show InChI InChI=1S/C30H26Cl2N4O2/c1-16(2)28-26-27(34-36(28)24-13-19(15-33)7-11-25(24)38-5)30(37)35(23-14-21(32)8-6-17(23)3)29(26)22-10-9-20(31)12-18(22)4/h6-14,16,29H,1-5H3
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n/an/a 452n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143546
PNG
(US8969341, 141)
Show SMILES COc1ccccc1-n1nc2C(=O)N([C@H](c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C |r|
Show InChI InChI=1S/C29H27Cl2N3O2/c1-16(2)27-25-26(32-34(27)22-8-6-7-9-24(22)36-5)29(35)33(23-15-20(31)11-10-17(23)3)28(25)21-13-12-19(30)14-18(21)4/h6-16,28H,1-5H3/t28-/m0/s1
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n/an/a 700n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143468
PNG
(US8969341, 109)
Show SMILES CCn1cc(cc(Cl)c1=O)N1C(c2c(nn(c2C(C)C)-c2ccccc2OC)C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H26Cl2N4O3/c1-5-32-15-19(14-20(30)27(32)35)33-26(17-10-12-18(29)13-11-17)23-24(28(33)36)31-34(25(23)16(2)3)21-8-6-7-9-22(21)37-4/h6-16,26H,5H2,1-4H3
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n/an/a 0.377n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143533
PNG
(US8969341, 136)
Show SMILES COc1ccc(cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(cc1)[N+]#[C-])c1cc(Cl)ccc1C)C#N
Show InChI InChI=1S/C30H24ClN5O2/c1-17(2)28-26-27(34-36(28)24-14-19(16-32)7-13-25(24)38-5)30(37)35(23-15-21(31)10-6-18(23)3)29(26)20-8-11-22(33-4)12-9-20/h6-15,17,29H,1-3,5H3
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n/an/a 0.242n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143537
PNG
(US8969341, 137)
Show SMILES COc1ccc(cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(cc1C)[N+]#[C-])c1cc(Cl)c(=O)n(C)c1)C#N
Show InChI InChI=1S/C30H25ClN6O3/c1-16(2)27-25-26(34-37(27)23-12-18(14-32)7-10-24(23)40-6)30(39)36(20-13-22(31)29(38)35(5)15-20)28(25)21-9-8-19(33-4)11-17(21)3/h7-13,15-16,28H,1-3,5-6H3
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n/an/a 1.03n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143548
PNG
(US8969341, 143)
Show SMILES COc1ccccc1-n1nc2C(=O)N([C@H](c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1OCCN(C)C |r|
Show InChI InChI=1S/C32H34Cl2N4O3/c1-19(2)30-28-29(35-38(30)24-9-7-8-10-26(24)40-6)32(39)37(31(28)23-13-11-21(33)17-20(23)3)25-18-22(34)12-14-27(25)41-16-15-36(4)5/h7-14,17-19,31H,15-16H2,1-6H3/t31-/m0/s1
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n/an/a 0.101n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143558
PNG
(US8969341, 147)
Show SMILES COc1nc(ncc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)c[nH]c1=O)N(C)C
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n/an/a 0.130n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143602
PNG
(US8969341, 157)
Show SMILES COc1nc(ncc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(cc1)C#N)c1cc(Cl)c[nH]c1=O)N(C)C
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n/an/a 0.166n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143636
PNG
(US8969341, 165)
Show SMILES CNc1ncc(c(OC)n1)-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)c[nH]c1=O
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n/an/a 0.408n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143661
PNG
(US8969341, 174)
Show SMILES CNc1ncc(c(OC)n1)-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(cc1)C#N)c1cc(Cl)c(=O)n(C)c1
Show InChI InChI=1S/C27H25ClN8O3/c1-14(2)22-20-21(33-36(22)19-12-31-27(30-3)32-24(19)39-5)26(38)35(17-10-18(28)25(37)34(4)13-17)23(20)16-8-6-15(11-29)7-9-16/h6-10,12-14,23H,1-5H3,(H,30,31,32)
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n/an/a 0.663n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143455
PNG
(US8969341, 100)
Show SMILES COc1ccccc1-n1nc2C(=O)N(c3ccc(F)c(Cl)c3)C(CCO)(c2c1C(C)C)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H26Cl2FN3O3/c1-17(2)27-25-26(33-35(27)23-6-4-5-7-24(23)38-3)28(37)34(20-12-13-22(32)21(31)16-20)29(25,14-15-36)18-8-10-19(30)11-9-18/h4-13,16-17,36H,14-15H2,1-3H3
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n/an/a 1.30n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143420
PNG
(US8969341, 69)
Show SMILES COc1ccccc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(C)cc1)c1cccc(Cl)c1F
Show InChI InChI=1S/C28H25ClFN3O2/c1-16(2)26-23-25(31-33(26)20-9-5-6-11-22(20)35-4)28(34)32(21-10-7-8-19(29)24(21)30)27(23)18-14-12-17(3)13-15-18/h5-16,27H,1-4H3
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n/an/a 1.80n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143435
PNG
(US8969341, 83)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CCO)c1cc(Cl)ccc1C)c1ccc(Cl)cc1C
Show InChI InChI=1S/C24H25Cl2N3O2/c1-13(2)22-20-21(27-28(22)9-10-30)24(31)29(19-12-17(26)6-5-14(19)3)23(20)18-8-7-16(25)11-15(18)4/h5-8,11-13,23,30H,9-10H2,1-4H3
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n/an/a 2.60n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143333
PNG
(US8969341, 1)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1Cc1ccccn1)c1cccc(Cl)c1F)c1ccc(Cl)cc1C
Show InChI InChI=1S/C27H23Cl2FN4O/c1-15(2)25-22-24(32-33(25)14-18-7-4-5-12-31-18)27(35)34(21-9-6-8-20(29)23(21)30)26(22)19-11-10-17(28)13-16(19)3/h4-13,15,26H,14H2,1-3H3
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n/an/a 7.80n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143370
PNG
(US8969341, 27)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CC=C)c1cc(Cl)ccc1C)c1ccc(Cl)cc1C
Show InChI InChI=1S/C25H25Cl2N3O/c1-6-11-29-23(14(2)3)21-22(28-29)25(31)30(20-13-18(27)8-7-15(20)4)24(21)19-10-9-17(26)12-16(19)5/h6-10,12-14,24H,1,11H2,2-5H3
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n/an/a 1.40n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143386
PNG
(US8969341, 40)
Show SMILES CNC(=O)Cn1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cccc(Cl)c1F
Show InChI InChI=1S/C24H23Cl2FN4O2/c1-12(2)22-19-21(29-30(22)11-18(32)28-4)24(33)31(17-7-5-6-16(26)20(17)27)23(19)15-9-8-14(25)10-13(15)3/h5-10,12,23H,11H2,1-4H3,(H,28,32)
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n/an/a 11.4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143389
PNG
(US8969341, 41)
Show SMILES CC(C)CCn1nc2C(=O)N(C(c2c1C1CC1)c1ccc(Cl)cc1C)c1cccc(Cl)c1F
Show InChI InChI=1S/C26H26Cl2FN3O/c1-14(2)11-12-31-24(16-7-8-16)21-23(30-31)26(33)32(20-6-4-5-19(28)22(20)29)25(21)18-10-9-17(27)13-15(18)3/h4-6,9-10,13-14,16,25H,7-8,11-12H2,1-3H3
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n/an/a 12n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143396
PNG
(US8969341, 47)
Show SMILES CCn1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1OCCN(C)C
Show InChI InChI=1S/C27H32Cl2N4O2/c1-7-32-25(16(2)3)23-24(30-32)27(34)33(26(23)20-10-8-18(28)14-17(20)4)21-15-19(29)9-11-22(21)35-13-12-31(5)6/h8-11,14-16,26H,7,12-13H2,1-6H3
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n/an/a 4.10n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143406
PNG
(US8969341, 55)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1Cc1ccccc1)c1cccc(Cl)c1F)c1ccc(Cl)cc1C
Show InChI InChI=1S/C28H24Cl2FN3O/c1-16(2)26-23-25(32-33(26)15-18-8-5-4-6-9-18)28(35)34(22-11-7-10-21(30)24(22)31)27(23)20-13-12-19(29)14-17(20)3/h4-14,16,27H,15H2,1-3H3
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n/an/a 24.2n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143424
PNG
(US8969341, 73)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1C1CCOCC1)c1cccc(Cl)c1F)c1ccc(Cl)cc1C
Show InChI InChI=1S/C26H26Cl2FN3O2/c1-14(2)24-21-23(30-32(24)17-9-11-34-12-10-17)26(33)31(20-6-4-5-19(28)22(20)29)25(21)18-8-7-16(27)13-15(18)3/h4-8,13-14,17,25H,9-12H2,1-3H3
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n/an/a 18n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143452
PNG
(US8969341, 97)
Show SMILES COc1ccccc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cn1)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C26H21Cl2FN4O2/c1-14(2)24-22-23(31-33(24)20-6-4-5-7-21(20)35-3)26(34)32(16-9-10-18(29)17(28)12-16)25(22)19-11-8-15(27)13-30-19/h4-14,25H,1-3H3
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n/an/a 6.20n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143464
PNG
(US8969341, 105)
Show SMILES COc1ccccc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)cc(NC(C)=O)c1
Show InChI InChI=1S/C30H28Cl2N4O3/c1-16(2)28-26-27(34-36(28)24-8-6-7-9-25(24)39-5)30(38)35(29(26)23-11-10-19(31)12-17(23)3)22-14-20(32)13-21(15-22)33-18(4)37/h6-16,29H,1-5H3,(H,33,37)
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n/an/a 2.90n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143479
PNG
(US8969341, 117a | US8969341, 117b)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1C1CCC(O)CC1)c1cccc(Cl)c1F)c1ccc(Cl)cc1C |(1.6,-3.66,;.26,-2.89,;-1.07,-3.66,;.26,-1.35,;-.98,-.44,;-2.52,-.44,;-3,1.02,;-1.75,1.93,;-1.75,3.47,;-.51,1.02,;1.03,1.02,;1.51,-.44,;3,-.84,;3.4,-2.33,;4.88,-2.73,;5.97,-1.64,;7.46,-2.03,;5.57,-.15,;4.09,.25,;-4.49,1.42,;-5.57,.33,;-7.06,.73,;-7.46,2.22,;-6.37,3.31,;-6.77,4.8,;-4.88,2.91,;-3.79,4,;-3.61,-1.53,;-3.21,-3.02,;-4.3,-4.11,;-5.79,-3.71,;-6.88,-4.8,;-6.19,-2.22,;-5.1,-1.13,;-5.87,.2,)|
Show InChI InChI=1S/C27H28Cl2FN3O2/c1-14(2)25-22-24(31-33(25)17-8-10-18(34)11-9-17)27(35)32(21-6-4-5-20(29)23(21)30)26(22)19-12-7-16(28)13-15(19)3/h4-7,12-14,17-18,26,34H,8-11H2,1-3H3
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n/an/a 12.9n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143549
PNG
(US8969341, 144)
Show SMILES COc1ccccc1-n1nc2C(=O)N([C@@H](c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1OCCN(C)C |r|
Show InChI InChI=1S/C32H34Cl2N4O3/c1-19(2)30-28-29(35-38(30)24-9-7-8-10-26(24)40-6)32(39)37(31(28)23-13-11-21(33)17-20(23)3)25-18-22(34)12-14-27(25)41-16-15-36(4)5/h7-14,17-19,31H,15-16H2,1-6H3/t31-/m1/s1
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n/an/a 3.90n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143334
PNG
(US8969341, 2)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1Cc1cccnc1)c1cccc(Cl)c1F)c1ccc(Cl)cc1C
Show InChI InChI=1S/C27H23Cl2FN4O/c1-15(2)25-22-24(32-33(25)14-17-6-5-11-31-13-17)27(35)34(21-8-4-7-20(29)23(21)30)26(22)19-10-9-18(28)12-16(19)3/h4-13,15,26H,14H2,1-3H3
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n/an/a 1.54E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143350
PNG
(US8969341, 18)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1Cc1nnn[nH]1)c1cccc(Cl)c1F)c1ccc(Cl)cc1
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n/an/a 7.61E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143363
PNG
(US8969341, 23)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CC(=O)N1CCNC(=O)C1)c1cc(Cl)ccc1C)c1ccc(Cl)cc1C
Show InChI InChI=1S/C28H29Cl2N5O3/c1-15(2)26-24-25(32-34(26)14-23(37)33-10-9-31-22(36)13-33)28(38)35(21-12-19(30)6-5-16(21)3)27(24)20-8-7-18(29)11-17(20)4/h5-8,11-12,15,27H,9-10,13-14H2,1-4H3,(H,31,36)
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n/an/a 2.36E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143404
PNG
(US8969341, 53)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CC1CCCN1C(=O)N(C)C)c1cc(Cl)ccc1C)c1ccc(Cl)cc1C
Show InChI InChI=1S/C30H35Cl2N5O2/c1-17(2)27-25-26(33-36(27)16-22-8-7-13-35(22)30(39)34(5)6)29(38)37(24-15-21(32)10-9-18(24)3)28(25)23-12-11-20(31)14-19(23)4/h9-12,14-15,17,22,28H,7-8,13,16H2,1-6H3
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n/an/a 4.86E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 345 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%