BindingDB logo
myBDB logout

Patent code US8969341

Compile Data Set for Download or QSAR

Found 345 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143333
PNG
(US8969341, 1)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1Cc1ccccn1)c1cccc(Cl)c1F)c1ccc(Cl)cc1C
Show InChI InChI=1S/C27H23Cl2FN4O/c1-15(2)25-22-24(32-33(25)14-18-7-4-5-12-31-18)27(35)34(21-9-6-8-20(29)23(21)30)26(22)19-11-10-17(28)13-16(19)3/h4-13,15,26H,14H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 7.80n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143341
PNG
(US8969341, 9)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CCc1c[nH]c2ccccc12)c1cccc(Cl)c1F)c1ccc(Cl)cc1C
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 22.8n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143343
PNG
(US8969341, 11)
Show SMILES CC(C)CCn1nc2C(=O)N(C(c2c1C(C)C)c1ccc(F)cc1)c1cccc(Cl)c1F
Show InChI InChI=1S/C25H26ClF2N3O/c1-14(2)12-13-30-23(15(3)4)20-22(29-30)25(32)31(19-7-5-6-18(26)21(19)28)24(20)16-8-10-17(27)11-9-16/h5-11,14-15,24H,12-13H2,1-4H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 31.4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143400
PNG
(US8969341, 51)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1C(=O)N(C)c1ccccc1)c1cc(Cl)ccc1C)c1ccc(Cl)cc1C
Show InChI InChI=1S/C30H28Cl2N4O2/c1-17(2)27-25-26(33-36(27)30(38)34(5)22-9-7-6-8-10-22)29(37)35(24-16-21(32)12-11-18(24)3)28(25)23-14-13-20(31)15-19(23)4/h6-17,28H,1-5H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 21.1n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143406
PNG
(US8969341, 55)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1Cc1ccccc1)c1cccc(Cl)c1F)c1ccc(Cl)cc1C
Show InChI InChI=1S/C28H24Cl2FN3O/c1-16(2)26-23-25(32-33(26)15-18-8-5-4-6-9-18)28(35)34(22-11-7-10-21(30)24(22)31)27(23)20-13-12-19(29)14-17(20)3/h4-14,16,27H,15H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 24.2n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143424
PNG
(US8969341, 73)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1C1CCOCC1)c1cccc(Cl)c1F)c1ccc(Cl)cc1C
Show InChI InChI=1S/C26H26Cl2FN3O2/c1-14(2)24-21-23(30-32(24)17-9-11-34-12-10-17)26(33)31(20-6-4-5-19(28)22(20)29)25(21)18-8-7-16(27)13-15(18)3/h4-8,13-14,17,25H,9-12H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 18n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143428
PNG
(US8969341, 77)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1-c1ccc(F)cc1F)c1cccc(Cl)c1F)c1ccc(Cl)cc1C
Show InChI InChI=1S/C27H20Cl2F3N3O/c1-13(2)25-22-24(33-35(25)20-10-8-16(30)12-19(20)31)27(36)34(21-6-4-5-18(29)23(21)32)26(22)17-9-7-15(28)11-14(17)3/h4-13,26H,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 14.3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143429
PNG
(US8969341, 78)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CCC#N)c1cccc(Cl)c1F)c1ccc(Cl)cc1C
Show InChI InChI=1S/C24H21Cl2FN4O/c1-13(2)22-19-21(29-30(22)11-5-10-28)24(32)31(18-7-4-6-17(26)20(18)27)23(19)16-9-8-15(25)12-14(16)3/h4,6-9,12-13,23H,5,11H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 15.6n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143450
PNG
(US8969341, 96)
Show SMILES CNC(=O)c1ccc(C)c(c1)-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(cc1)C(F)(F)F)c1cc(Cl)ccc1C
Show InChI InChI=1S/C31H28ClF3N4O2/c1-16(2)27-25-26(37-39(27)24-14-20(29(40)36-5)8-6-18(24)4)30(41)38(23-15-22(32)13-7-17(23)3)28(25)19-9-11-21(12-10-19)31(33,34)35/h6-16,28H,1-5H3,(H,36,40)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 5.70n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143454
PNG
(US8969341, 99)
Show SMILES COc1ccccc1-n1nc2C(=O)N(c3ccc(F)c(Cl)c3)C(CC(O)CO)(c2c1C(C)C)c1ccc(Cl)cc1
Show InChI InChI=1S/C30H28Cl2FN3O4/c1-17(2)28-26-27(34-36(28)24-6-4-5-7-25(24)40-3)29(39)35(20-12-13-23(33)22(32)14-20)30(26,15-21(38)16-37)18-8-10-19(31)11-9-18/h4-14,17,21,37-38H,15-16H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.5n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143468
PNG
(US8969341, 109)
Show SMILES CCn1cc(cc(Cl)c1=O)N1C(c2c(nn(c2C(C)C)-c2ccccc2OC)C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H26Cl2N4O3/c1-5-32-15-19(14-20(30)27(32)35)33-26(17-10-12-18(29)13-11-17)23-24(28(33)36)31-34(25(23)16(2)3)21-8-6-7-9-22(21)37-4/h6-16,26H,5H2,1-4H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2.20n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143479
PNG
(US8969341, 117a | US8969341, 117b)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1C1CCC(O)CC1)c1cccc(Cl)c1F)c1ccc(Cl)cc1C |(1.6,-3.66,;.26,-2.89,;-1.07,-3.66,;.26,-1.35,;-.98,-.44,;-2.52,-.44,;-3,1.02,;-1.75,1.93,;-1.75,3.47,;-.51,1.02,;1.03,1.02,;1.51,-.44,;3,-.84,;3.4,-2.33,;4.88,-2.73,;5.97,-1.64,;7.46,-2.03,;5.57,-.15,;4.09,.25,;-4.49,1.42,;-5.57,.33,;-7.06,.73,;-7.46,2.22,;-6.37,3.31,;-6.77,4.8,;-4.88,2.91,;-3.79,4,;-3.61,-1.53,;-3.21,-3.02,;-4.3,-4.11,;-5.79,-3.71,;-6.88,-4.8,;-6.19,-2.22,;-5.1,-1.13,;-5.87,.2,)|
Show InChI InChI=1S/C27H28Cl2FN3O2/c1-14(2)25-22-24(31-33(25)17-8-10-18(34)11-9-17)27(35)32(21-6-4-5-20(29)23(21)30)26(22)19-12-7-16(28)13-15(19)3/h4-7,12-14,17-18,26,34H,8-11H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 12.9n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143544
PNG
(US8969341, 139)
Show SMILES CC(C)c1c2[C@@H](N(C(=O)c2nn1CCO)c1cccc(Cl)c1F)c1ccc(Cl)cc1C |r|
Show InChI InChI=1S/C23H22Cl2FN3O2/c1-12(2)21-18-20(27-28(21)9-10-30)23(31)29(17-6-4-5-16(25)19(17)26)22(18)15-8-7-14(24)11-13(15)3/h4-8,11-12,22,30H,9-10H2,1-3H3/t22-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2.60n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143348
PNG
(US8969341, 16)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1Cc1cc(C)nn1C)c1cccc(Cl)c1F)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H24Cl2FN5O/c1-14(2)24-21-23(31-33(24)13-18-12-15(3)30-32(18)4)26(35)34(20-7-5-6-19(28)22(20)29)25(21)16-8-10-17(27)11-9-16/h5-12,14,25H,13H2,1-4H3
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.59E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143353
PNG
(US8969341, 19)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CC(=O)N1CCC(O)CC1)c1cc(Cl)ccc1C)c1ccc(Cl)cc1C
Show InChI InChI=1S/C29H32Cl2N4O3/c1-16(2)27-25-26(32-34(27)15-24(37)33-11-9-21(36)10-12-33)29(38)35(23-14-20(31)6-5-17(23)3)28(25)22-8-7-19(30)13-18(22)4/h5-8,13-14,16,21,28,36H,9-12,15H2,1-4H3
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 3.67E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143360
PNG
(US8969341, 22)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CC(=O)N1CCN(CC1)C(C)=O)c1cc(Cl)ccc1C)c1ccc(Cl)cc1C
Show InChI InChI=1S/C30H33Cl2N5O3/c1-17(2)28-26-27(33-36(28)16-25(39)35-12-10-34(11-13-35)20(5)38)30(40)37(24-15-22(32)7-6-18(24)3)29(26)23-9-8-21(31)14-19(23)4/h6-9,14-15,17,29H,10-13,16H2,1-5H3
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.61E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143370
PNG
(US8969341, 27)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CC=C)c1cc(Cl)ccc1C)c1ccc(Cl)cc1C
Show InChI InChI=1S/C25H25Cl2N3O/c1-6-11-29-23(14(2)3)21-22(28-29)25(31)30(20-13-18(27)8-7-15(20)4)24(21)19-10-9-17(26)12-16(19)5/h6-10,12-14,24H,1,11H2,2-5H3
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.49E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143372
PNG
(US8969341, 29)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CC1(O)CCN(CC1)C(C)=O)c1cc(Cl)ccc1C)c1ccc(Cl)cc1C
Show InChI InChI=1S/C30H34Cl2N4O3/c1-17(2)27-25-26(33-35(27)16-30(39)10-12-34(13-11-30)20(5)37)29(38)36(24-15-22(32)7-6-18(24)3)28(25)23-9-8-21(31)14-19(23)4/h6-9,14-15,17,28,39H,10-13,16H2,1-5H3
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.19E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143400
PNG
(US8969341, 51)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1C(=O)N(C)c1ccccc1)c1cc(Cl)ccc1C)c1ccc(Cl)cc1C
Show InChI InChI=1S/C30H28Cl2N4O2/c1-17(2)27-25-26(33-36(27)30(38)34(5)22-9-7-6-8-10-22)29(37)35(24-16-21(32)12-11-18(24)3)28(25)23-14-13-20(31)15-19(23)4/h6-17,28H,1-5H3
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 4.07E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143428
PNG
(US8969341, 77)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1-c1ccc(F)cc1F)c1cccc(Cl)c1F)c1ccc(Cl)cc1C
Show InChI InChI=1S/C27H20Cl2F3N3O/c1-13(2)25-22-24(33-35(25)20-10-8-16(30)12-19(20)31)27(36)34(21-6-4-5-18(29)23(21)32)26(22)17-9-7-15(28)11-14(17)3/h4-13,26H,1-3H3
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2.58E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143453
PNG
(US8969341, 98)
Show SMILES COc1ccccc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cn1)c1cc(Cl)ccc1C
Show InChI InChI=1S/C27H24Cl2N4O2/c1-15(2)25-23-24(31-33(25)20-7-5-6-8-22(20)35-4)27(34)32(21-13-17(28)10-9-16(21)3)26(23)19-12-11-18(29)14-30-19/h5-15,26H,1-4H3
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 3.26E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143466
PNG
(US8969341, 107)
Show SMILES COc1ccccc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C27H22ClF2N3O2/c1-15(2)25-23-24(31-33(25)21-6-4-5-7-22(21)35-3)27(34)32(18-12-13-19(29)20(30)14-18)26(23)16-8-10-17(28)11-9-16/h4-15,26H,1-3H3
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 5.81E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143479
PNG
(US8969341, 117a | US8969341, 117b)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1C1CCC(O)CC1)c1cccc(Cl)c1F)c1ccc(Cl)cc1C |(1.6,-3.66,;.26,-2.89,;-1.07,-3.66,;.26,-1.35,;-.98,-.44,;-2.52,-.44,;-3,1.02,;-1.75,1.93,;-1.75,3.47,;-.51,1.02,;1.03,1.02,;1.51,-.44,;3,-.84,;3.4,-2.33,;4.88,-2.73,;5.97,-1.64,;7.46,-2.03,;5.57,-.15,;4.09,.25,;-4.49,1.42,;-5.57,.33,;-7.06,.73,;-7.46,2.22,;-6.37,3.31,;-6.77,4.8,;-4.88,2.91,;-3.79,4,;-3.61,-1.53,;-3.21,-3.02,;-4.3,-4.11,;-5.79,-3.71,;-6.88,-4.8,;-6.19,-2.22,;-5.1,-1.13,;-5.87,.2,)|
Show InChI InChI=1S/C27H28Cl2FN3O2/c1-14(2)25-22-24(31-33(25)17-8-10-18(34)11-9-17)27(35)32(21-6-4-5-20(29)23(21)30)26(22)19-12-7-16(28)13-15(19)3/h4-7,12-14,17-18,26,34H,8-11H2,1-3H3
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.51E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143497
PNG
(US8969341, 123)
Show SMILES CC(C)(C)c1[nH]nc2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cccc(Cl)c1F
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 8.84E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM143511
PNG
(US8969341, 126)
Show SMILES COc1ccc(CN)cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C
Show InChI InChI=1S/C30H30Cl2N4O2/c1-16(2)28-26-27(34-36(28)24-13-19(15-33)7-11-25(24)38-5)30(37)35(23-14-21(32)8-6-17(23)3)29(26)22-10-9-20(31)12-18(22)4/h6-14,16,29H,15,33H2,1-5H3
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 150n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143370
PNG
(US8969341, 27)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CC=C)c1cc(Cl)ccc1C)c1ccc(Cl)cc1C
Show InChI InChI=1S/C25H25Cl2N3O/c1-6-11-29-23(14(2)3)21-22(28-29)25(31)30(20-13-18(27)8-7-15(20)4)24(21)19-10-9-17(26)12-16(19)5/h6-10,12-14,24H,1,11H2,2-5H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.10n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143466
PNG
(US8969341, 107)
Show SMILES COc1ccccc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C27H22ClF2N3O2/c1-15(2)25-23-24(31-33(25)21-6-4-5-7-22(21)35-3)27(34)32(18-12-13-19(29)20(30)14-18)26(23)16-8-10-17(28)11-9-16/h4-15,26H,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.701n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143472
PNG
(US8969341, 112)
Show SMILES COCCn1cc(cc(Cl)c1=O)N1C(c2c(nn(c2C(C)C)-c2ccccc2OC)C1=O)c1ccc(Cl)cc1C
Show InChI InChI=1S/C30H30Cl2N4O4/c1-17(2)27-25-26(33-36(27)23-8-6-7-9-24(23)40-5)30(38)35(28(25)21-11-10-19(31)14-18(21)3)20-15-22(32)29(37)34(16-20)12-13-39-4/h6-11,14-17,28H,12-13H2,1-5H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.267n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143477
PNG
(US8969341, 115)
Show SMILES COc1ccccc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)c(=O)n(CCN(C)C)c1
Show InChI InChI=1S/C30H31Cl2N5O3/c1-18(2)27-25-26(33-37(27)23-8-6-7-9-24(23)40-5)30(39)36(28(25)19-10-12-20(31)13-11-19)21-16-22(32)29(38)35(17-21)15-14-34(3)4/h6-13,16-18,28H,14-15H2,1-5H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.77n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143483
PNG
(US8969341, 119)
Show SMILES COc1ccccc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ncc1OC
Show InChI InChI=1S/C28H26Cl2N4O3/c1-15(2)26-24-25(32-34(26)19-8-6-7-9-21(19)36-4)28(35)33(20-13-23(30)31-14-22(20)37-5)27(24)18-11-10-17(29)12-16(18)3/h6-15,27H,1-5H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.926n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143496
PNG
(US8969341, 122)
Show SMILES COc1ccncc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C
Show InChI InChI=1S/C28H26Cl2N4O2/c1-15(2)26-24-25(32-34(26)22-14-31-11-10-23(22)36-5)28(35)33(21-13-19(30)7-6-16(21)3)27(24)20-9-8-18(29)12-17(20)4/h6-15,27H,1-5H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.99n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143507
PNG
(US8969341, 125)
Show SMILES COc1ccc(cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C)C#N
Show InChI InChI=1S/C30H26Cl2N4O2/c1-16(2)28-26-27(34-36(28)24-13-19(15-33)7-11-25(24)38-5)30(37)35(23-14-21(32)8-6-17(23)3)29(26)22-10-9-20(31)12-18(22)4/h6-14,16,29H,1-5H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.187n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143546
PNG
(US8969341, 141)
Show SMILES COc1ccccc1-n1nc2C(=O)N([C@H](c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C |r|
Show InChI InChI=1S/C29H27Cl2N3O2/c1-16(2)27-25-26(32-34(27)22-8-6-7-9-24(22)36-5)29(35)33(23-15-20(31)11-10-17(23)3)28(25)21-13-12-19(30)14-18(21)4/h6-16,28H,1-5H3/t28-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.161n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143550
PNG
(US8969341, 145)
Show SMILES COc1ncc(c(OC)n1)-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)cn(C)c1=O
Show InChI InChI=1S/C26H24Cl2N6O4/c1-13(2)21-19-20(31-34(21)18-11-29-26(38-5)30-23(18)37-4)25(36)33(17-10-16(28)12-32(3)24(17)35)22(19)14-6-8-15(27)9-7-14/h6-13,22H,1-5H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.530n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143610
PNG
(US8969341, 159)
Show SMILES COc1ncc(c(OC)n1)-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(cc1)C#N)c1c[nH]c(=O)c(Cl)c1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.772n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143644
PNG
(US8969341, 167)
Show SMILES COc1ncc(c(OC)n1)-n1nc2C(=O)N([C@@H](c2c1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)c[nH]c1=O |r|
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 14.8n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143670
PNG
(US8969341, 177)
Show SMILES COc1ncc(c(OC)n1)-n1nc2C(=O)N([C@@H](c2c1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)c(=O)n(C)c1 |r|
Show InChI InChI=1S/C26H24Cl2N6O4/c1-13(2)21-19-20(31-34(21)18-11-29-26(38-5)30-23(18)37-4)25(36)33(16-10-17(28)24(35)32(3)12-16)22(19)14-6-8-15(27)9-7-14/h6-13,22H,1-5H3/t22-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 267n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143682
PNG
(US8969341, 185)
Show SMILES COc1ncc(c(OC)n1)-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1F)c1cc(Cl)cn(C)c1=O
Show InChI InChI=1S/C26H23Cl2FN6O4/c1-12(2)21-19-20(32-35(21)18-10-30-26(39-5)31-23(18)38-4)25(37)34(17-9-14(28)11-33(3)24(17)36)22(19)15-7-6-13(27)8-16(15)29/h6-12,22H,1-5H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.44n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143685
PNG
(US8969341, 186)
Show SMILES COc1ncc(c(OC)n1)-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)c(F)c1)c1cc(Cl)c(=O)n(C)c1
Show InChI InChI=1S/C26H23Cl2FN6O4/c1-12(2)21-19-20(32-35(21)18-10-30-26(39-5)31-23(18)38-4)25(37)34(14-9-16(28)24(36)33(3)11-14)22(19)13-6-7-15(27)17(29)8-13/h6-12,22H,1-5H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.384n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143723
PNG
(US8969341, 196)
Show SMILES COc1nc(ncc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)c(F)c1)c1cc(Cl)c[nH]c1=O)N(C)C
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.165n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143465
PNG
(US8969341, 106)
Show SMILES COc1ccc(cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C)C(=O)N(C)C
Show InChI InChI=1S/C32H32Cl2N4O3/c1-17(2)29-27-28(35-38(29)25-15-20(31(39)36(5)6)9-13-26(25)41-7)32(40)37(24-16-22(34)10-8-18(24)3)30(27)23-12-11-21(33)14-19(23)4/h8-17,30H,1-7H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2.10n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143420
PNG
(US8969341, 69)
Show SMILES COc1ccccc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(C)cc1)c1cccc(Cl)c1F
Show InChI InChI=1S/C28H25ClFN3O2/c1-16(2)26-23-25(31-33(26)20-9-5-6-11-22(20)35-4)28(34)32(21-10-7-8-19(29)24(21)30)27(23)18-14-12-17(3)13-15-18/h5-16,27H,1-4H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.80n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143345
PNG
(US8969341, 13)
Show SMILES CCN1CCN(CCn2nc3C(=O)N(C(c3c2C(C)C)c2ccc(Cl)cc2)c2cccc(Cl)c2F)C1=O
Show InChI InChI=1S/C27H28Cl2FN5O2/c1-4-32-12-13-33(27(32)37)14-15-34-24(16(2)3)21-23(31-34)26(36)35(20-7-5-6-19(29)22(20)30)25(21)17-8-10-18(28)11-9-17/h5-11,16,25H,4,12-15H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 8.90n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143348
PNG
(US8969341, 16)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1Cc1cc(C)nn1C)c1cccc(Cl)c1F)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H24Cl2FN5O/c1-14(2)24-21-23(31-33(24)13-18-12-15(3)30-32(18)4)26(35)34(20-7-5-6-19(28)22(20)29)25(21)16-8-10-17(27)11-9-16/h5-12,14,25H,13H2,1-4H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 7.90n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143356
PNG
(US8969341, 20)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CC(=O)N1CCC(CCO)CC1)c1cc(Cl)ccc1C)c1ccc(Cl)cc1C
Show InChI InChI=1S/C31H36Cl2N4O3/c1-18(2)29-27-28(34-36(29)17-26(39)35-12-9-21(10-13-35)11-14-38)31(40)37(25-16-23(33)6-5-19(25)3)30(27)24-8-7-22(32)15-20(24)4/h5-8,15-16,18,21,30,38H,9-14,17H2,1-4H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 4.20n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143365
PNG
(US8969341, 25)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CC1CCN(CC1)C(C)=O)c1cc(Cl)ccc1C)c1ccc(Cl)cc1C
Show InChI InChI=1S/C30H34Cl2N4O2/c1-17(2)28-26-27(33-35(28)16-21-10-12-34(13-11-21)20(5)37)30(38)36(25-15-23(32)7-6-18(25)3)29(26)24-9-8-22(31)14-19(24)4/h6-9,14-15,17,21,29H,10-13,16H2,1-5H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2.40n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143381
PNG
(US8969341, 35)
Show SMILES COCCn1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cccc(Cl)c1F
Show InChI InChI=1S/C24H24Cl2FN3O2/c1-13(2)22-19-21(28-29(22)10-11-32-4)24(31)30(18-7-5-6-17(26)20(18)27)23(19)16-9-8-15(25)12-14(16)3/h5-9,12-13,23H,10-11H2,1-4H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 4.20n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143390
PNG
(US8969341, 42)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CCCO)c1cccc(Cl)c1F)c1ccc(Cl)cc1C
Show InChI InChI=1S/C24H24Cl2FN3O2/c1-13(2)22-19-21(28-29(22)10-5-11-31)24(32)30(18-7-4-6-17(26)20(18)27)23(19)16-9-8-15(25)12-14(16)3/h4,6-9,12-13,23,31H,5,10-11H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 6n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143415
PNG
(US8969341, 64)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1-c1ccc(cc1)C(N)=O)c1cccc(Cl)c1F)c1ccc(Cl)cc1C
Show InChI InChI=1S/C28H23Cl2FN4O2/c1-14(2)25-22-24(33-35(25)18-10-7-16(8-11-18)27(32)36)28(37)34(21-6-4-5-20(30)23(21)31)26(22)19-12-9-17(29)13-15(19)3/h4-14,26H,1-3H3,(H2,32,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 11.5n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM143466
PNG
(US8969341, 107)
Show SMILES COc1ccccc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C27H22ClF2N3O2/c1-15(2)25-23-24(31-33(25)21-6-4-5-7-22(21)35-3)27(34)32(18-12-13-19(29)20(30)14-18)26(23)16-8-10-17(28)11-9-16/h4-15,26H,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.70n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8969341 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SC8
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 345 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%