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Patent code US9006283

Compile Data Set for Download or QSAR
Found 6 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Amyloid-beta precursor protein


(Rattus norvegicus (Rat))		BDBM155391
PNG
(US9006283, 1)
Show SMILES COc1ccccc1NC(=O)C(=O)N\N=C(\CC(=O)c1cccs1)C(F)(F)F
Show InChI InChI=1S/C17H14F3N3O4S/c1-27-12-6-3-2-5-10(12)21-15(25)16(26)23-22-14(17(18,19)20)9-11(24)13-7-4-8-28-13/h2-8H,9H2,1H3,(H,21,25)(H,23,26)/b22-14-
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 3.90E+3n/an/an/an/a8.037



Acumen Pharmaceuticals, Inc.

US Patent


Assay Description
In this assay, assembly of Abeta 1-42 oligomer formation is monitored by FRET using N-terminal conjugates of fluorescein-Abeta 1-42 as both the donor...

US Patent US9006283 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H3Z
More data for this
Ligand-Target Pair
Amyloid-beta precursor protein


(Rattus norvegicus (Rat))		BDBM155393
PNG
(US9006283, 3)
Show SMILES CCOC(=O)c1c(NC(=O)C(=O)N\N=C\c2c(O)ccc3ccccc23)sc2CC(C)CCc12
Show InChI InChI=1S/C25H25N3O5S/c1-3-33-25(32)21-17-10-8-14(2)12-20(17)34-24(21)27-22(30)23(31)28-26-13-18-16-7-5-4-6-15(16)9-11-19(18)29/h4-7,9,11,13-14,29H,3,8,10,12H2,1-2H3,(H,27,30)(H,28,31)/b26-13+
PDB

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US Patent
n/an/a 4.40E+3n/an/an/an/a8.037



Acumen Pharmaceuticals, Inc.

US Patent


Assay Description
In this assay, assembly of Abeta 1-42 oligomer formation is monitored by FRET using N-terminal conjugates of fluorescein-Abeta 1-42 as both the donor...

US Patent US9006283 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H3Z
More data for this
Ligand-Target Pair
Amyloid-beta precursor protein


(Rattus norvegicus (Rat))		BDBM155395
PNG
(US9006283, 5)
Show SMILES COc1ccccc1NC(=O)C(=O)N1N=C(CC(C)C)CC1(O)C(F)(F)F |t:15|
Show InChI InChI=1S/C17H20F3N3O4/c1-10(2)8-11-9-16(26,17(18,19)20)23(22-11)15(25)14(24)21-12-6-4-5-7-13(12)27-3/h4-7,10,26H,8-9H2,1-3H3,(H,21,24)
PDB

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US Patent
n/an/a 3.20E+3n/an/an/an/a8.037



Acumen Pharmaceuticals, Inc.

US Patent


Assay Description
In this assay, assembly of Abeta 1-42 oligomer formation is monitored by FRET using N-terminal conjugates of fluorescein-Abeta 1-42 as both the donor...

US Patent US9006283 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H3Z
More data for this
Ligand-Target Pair
Amyloid-beta precursor protein


(Rattus norvegicus (Rat))		BDBM155392
PNG
(US9006283, 2)
Show SMILES CCOC(=O)c1c(NC(=O)C(=O)N\N=C\c2cccc(OC)c2O)sc2CC(C)CCc12
Show InChI InChI=1S/C22H25N3O6S/c1-4-31-22(29)17-14-9-8-12(2)10-16(14)32-21(17)24-19(27)20(28)25-23-11-13-6-5-7-15(30-3)18(13)26/h5-7,11-12,26H,4,8-10H2,1-3H3,(H,24,27)(H,25,28)/b23-11+
PDB

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US Patent
n/an/a 3.50E+3n/an/an/an/a8.037



Acumen Pharmaceuticals, Inc.

US Patent


Assay Description
In this assay, assembly of Abeta 1-42 oligomer formation is monitored by FRET using N-terminal conjugates of fluorescein-Abeta 1-42 as both the donor...

US Patent US9006283 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H3Z
More data for this
Ligand-Target Pair
Amyloid-beta precursor protein


(Rattus norvegicus (Rat))		BDBM155394
PNG
(US9006283, 4)
Show SMILES CCOC(=O)c1c(NC(=O)C(=O)N\N=C\c2ccccc2O)sc2CC(C)CCc12
Show InChI InChI=1S/C21H23N3O5S/c1-3-29-21(28)17-14-9-8-12(2)10-16(14)30-20(17)23-18(26)19(27)24-22-11-13-6-4-5-7-15(13)25/h4-7,11-12,25H,3,8-10H2,1-2H3,(H,23,26)(H,24,27)/b22-11+
PDB

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US Patent
n/an/a 1.10E+3n/an/an/an/a8.037



Acumen Pharmaceuticals, Inc.

US Patent


Assay Description
In this assay, assembly of Abeta 1-42 oligomer formation is monitored by FRET using N-terminal conjugates of fluorescein-Abeta 1-42 as both the donor...

US Patent US9006283 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H3Z
More data for this
Ligand-Target Pair
Amyloid-beta precursor protein


(Rattus norvegicus (Rat))		BDBM155396
PNG
(US9006283, 6)
Show SMILES Oc1ccccc1C(=O)N\N=C\c1ccc2ccccc2c1O
Show InChI InChI=1S/C18H14N2O3/c21-16-8-4-3-7-15(16)18(23)20-19-11-13-10-9-12-5-1-2-6-14(12)17(13)22/h1-11,21-22H,(H,20,23)/b19-11+
PDB

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US Patent
n/an/a 3.80E+3n/an/an/an/a8.037



Acumen Pharmaceuticals, Inc.

US Patent


Assay Description
In this assay, assembly of Abeta 1-42 oligomer formation is monitored by FRET using N-terminal conjugates of fluorescein-Abeta 1-42 as both the donor...

US Patent US9006283 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H3Z
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%