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Patent code US9067922

Compile Data Set for Download or QSAR

Found 243 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165674
PNG
(US9067922, 8)
Show SMILES COc1cc(F)cc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)c1
Show InChI InChI=1S/C19H13F2N3O4S/c1-27-15-7-14(21)8-16(9-15)28-18-4-3-17(6-12(18)10-22)29(25,26)24-19-5-2-13(20)11-23-19/h2-9,11H,1H3,(H,23,24)
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n/an/a 119n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165680
PNG
(US9067922, 14)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3cccc(c3)C#N)c(c2)C#N)nc1
Show InChI InChI=1S/C19H11FN4O3S/c20-15-4-7-19(23-12-15)24-28(25,26)17-5-6-18(14(9-17)11-22)27-16-3-1-2-13(8-16)10-21/h1-9,12H,(H,23,24)
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n/an/a 206n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165698
PNG
(US9067922, 32)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3cc(F)cc(F)c3Cl)c(c2)C#N)nc1
Show InChI InChI=1S/C18H9ClF3N3O3S/c19-18-14(22)6-12(21)7-16(18)28-15-3-2-13(5-10(15)8-23)29(26,27)25-17-4-1-11(20)9-24-17/h1-7,9H,(H,24,25)
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n/an/a 212n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165700
PNG
(US9067922, 34)
Show SMILES Cc1cc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)ccc1Cl
Show InChI InChI=1S/C19H13ClFN3O3S/c1-12-8-15(3-5-17(12)20)27-18-6-4-16(9-13(18)10-22)28(25,26)24-19-7-2-14(21)11-23-19/h2-9,11H,1H3,(H,23,24)
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n/an/a 80n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165708
PNG
(US9067922, 42)
Show SMILES Cc1ccc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)c(Cl)c1
Show InChI InChI=1S/C19H13ClFN3O3S/c1-12-2-5-18(16(20)8-12)27-17-6-4-15(9-13(17)10-22)28(25,26)24-19-7-3-14(21)11-23-19/h2-9,11H,1H3,(H,23,24)
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n/an/a 383n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165714
PNG
(US9067922, 48)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(F)c(c3)C(F)(F)F)c(c2)C#N)nc1
Show InChI InChI=1S/C19H10F5N3O3S/c20-12-1-6-18(26-10-12)27-31(28,29)14-3-5-17(11(7-14)9-25)30-13-2-4-16(21)15(8-13)19(22,23)24/h1-8,10H,(H,26,27)
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n/an/a 683n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165720
PNG
(US9067922, 54)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(cc3)C(F)(F)F)c(c2)C#N)nc1
Show InChI InChI=1S/C19H11F4N3O3S/c20-14-3-8-18(25-11-14)26-30(27,28)16-6-7-17(12(9-16)10-24)29-15-4-1-13(2-5-15)19(21,22)23/h1-9,11H,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165736
PNG
(US9067922, 70)
Show SMILES COc1ncc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc1Cl
Show InChI InChI=1S/C18H12ClFN4O4S/c1-27-18-15(19)7-13(10-23-18)28-16-4-3-14(6-11(16)8-21)29(25,26)24-17-5-2-12(20)9-22-17/h2-7,9-10H,1H3,(H,22,24)
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n/an/a 25n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165746
PNG
(US9067922, 80)
Show SMILES Clc1ccc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccccn2)c(I)c1
Show InChI InChI=1S/C18H11ClIN3O3S/c19-13-4-6-17(15(20)10-13)26-16-7-5-14(9-12(16)11-21)27(24,25)23-18-3-1-2-8-22-18/h1-10H,(H,22,23)
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n/an/a 728n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165752
PNG
(US9067922, 87)
Show SMILES Clc1cc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccncn2)ccc1C#N
Show InChI InChI=1S/C18H10ClN5O3S/c19-16-8-14(2-1-12(16)9-20)27-17-4-3-15(7-13(17)10-21)28(25,26)24-18-5-6-22-11-23-18/h1-8,11H,(H,22,23,24)
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n/an/a>7.67E+3n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165756
PNG
(US9067922, 91)
Show SMILES Fc1cnc(NS(=O)(=O)c2ccc(Oc3ccc(C#N)c(Cl)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C18H9ClFN5O3S/c19-16-6-14(2-1-11(16)7-21)28-17-4-3-15(5-12(17)8-22)29(26,27)25-18-23-9-13(20)10-24-18/h1-6,9-10H,(H,23,24,25)
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n/an/a 1.95E+3n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165770
PNG
(US9067922, 105)
Show SMILES CC(C)c1cc(C)cc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)c1
Show InChI InChI=1S/C22H20FN3O3S/c1-14(2)16-8-15(3)9-19(10-16)29-21-6-5-20(11-17(21)12-24)30(27,28)26-22-7-4-18(23)13-25-22/h4-11,13-14H,1-3H3,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165787
PNG
(US9067922, 122)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(Cl)c(Cl)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C18H10Cl2FN3O3S/c19-15-4-2-13(8-16(15)20)27-17-5-3-14(7-11(17)9-22)28(25,26)24-18-6-1-12(21)10-23-18/h1-8,10H,(H,23,24)
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n/an/a 99n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165795
PNG
(US9067922, 130)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3cc(F)c(F)cc3F)c(c2)C#N)nc1
Show InChI InChI=1S/C18H9F4N3O3S/c19-11-1-4-18(24-9-11)25-29(26,27)12-2-3-16(10(5-12)8-23)28-17-7-14(21)13(20)6-15(17)22/h1-7,9H,(H,24,25)
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n/an/a 119n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165797
PNG
(US9067922, 132)
Show SMILES COc1ccc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc1F
Show InChI InChI=1S/C19H13F2N3O4S/c1-27-18-5-3-14(9-16(18)21)28-17-6-4-15(8-12(17)10-22)29(25,26)24-19-7-2-13(20)11-23-19/h2-9,11H,1H3,(H,23,24)
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n/an/a 38n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165806
PNG
(US9067922, 141)
Show SMILES Cc1cc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C19H13F2N3O3S/c1-12-8-15(3-5-17(12)21)27-18-6-4-16(9-13(18)10-22)28(25,26)24-19-7-2-14(20)11-23-19/h2-9,11H,1H3,(H,23,24)
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n/an/a 43n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165808
PNG
(US9067922, 143)
Show SMILES COc1cc(Cl)ccc1Oc1ccc(cc1C#N)S(=O)(=O)Nc1ccc(F)cn1
Show InChI InChI=1S/C19H13ClFN3O4S/c1-27-18-9-13(20)2-5-17(18)28-16-6-4-15(8-12(16)10-22)29(25,26)24-19-7-3-14(21)11-23-19/h2-9,11H,1H3,(H,23,24)
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n/an/a 79n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165812
PNG
(US9067922, 147)
Show SMILES Cc1c(F)ccc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)c1Cl
Show InChI InChI=1S/C19H12ClF2N3O3S/c1-11-15(22)4-6-17(19(11)20)28-16-5-3-14(8-12(16)9-23)29(26,27)25-18-7-2-13(21)10-24-18/h2-8,10H,1H3,(H,24,25)
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n/an/a 187n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165816
PNG
(US9067922, 151)
Show SMILES CCOc1ccccc1Oc1ccc(cc1C#N)S(=O)(=O)Nc1ccc(F)cn1
Show InChI InChI=1S/C20H16FN3O4S/c1-2-27-18-5-3-4-6-19(18)28-17-9-8-16(11-14(17)12-22)29(25,26)24-20-10-7-15(21)13-23-20/h3-11,13H,2H2,1H3,(H,23,24)
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n/an/a>1.00E+4n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165820
PNG
(US9067922, 155)
Show SMILES COc1ccc(C)cc1Oc1ccc(cc1C#N)S(=O)(=O)Nc1ccc(F)cn1
Show InChI InChI=1S/C20H16FN3O4S/c1-13-3-6-18(27-2)19(9-13)28-17-7-5-16(10-14(17)11-22)29(25,26)24-20-8-4-15(21)12-23-20/h3-10,12H,1-2H3,(H,23,24)
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n/an/a 191n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165822
PNG
(US9067922, 157)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(F)c(F)c3F)c(c2)C#N)nc1
Show InChI InChI=1S/C18H9F4N3O3S/c19-11-1-6-16(24-9-11)25-29(26,27)12-2-4-14(10(7-12)8-23)28-15-5-3-13(20)17(21)18(15)22/h1-7,9H,(H,24,25)
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n/an/a 51n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165830
PNG
(US9067922, 165)
Show SMILES COc1c(F)ccc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)c1C
Show InChI InChI=1S/C20H15F2N3O4S/c1-12-17(7-5-16(22)20(12)28-2)29-18-6-4-15(9-13(18)10-23)30(26,27)25-19-8-3-14(21)11-24-19/h3-9,11H,1-2H3,(H,24,25)
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n/an/a 139n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165852
PNG
(US9067922, 188)
Show SMILES COc1ccc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc1
Show InChI InChI=1S/C19H14FN3O4S/c1-26-15-3-5-16(6-4-15)27-18-8-7-17(10-13(18)11-21)28(24,25)23-19-9-2-14(20)12-22-19/h2-10,12H,1H3,(H,22,23)
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n/an/a 3.74E+3n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165855
PNG
(US9067922, 191)
Show SMILES Cc1ccc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc1
Show InChI InChI=1S/C19H14FN3O3S/c1-13-2-5-16(6-3-13)26-18-8-7-17(10-14(18)11-21)27(24,25)23-19-9-4-15(20)12-22-19/h2-10,12H,1H3,(H,22,23)
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n/an/a 1.99E+3n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165876
PNG
(US9067922, 215)
Show SMILES Fc1ccc(NS(=O)(=O)c2cc(Cl)c(Oc3ccc(C#N)c(F)c3)cc2F)nc1
Show InChI InChI=1S/C18H9ClF3N3O3S/c19-13-6-17(29(26,27)25-18-4-2-11(20)9-24-18)15(22)7-16(13)28-12-3-1-10(8-23)14(21)5-12/h1-7,9H,(H,24,25)
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n/an/a>1.00E+4n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165877
PNG
(US9067922, 216)
Show SMILES Cc1ccnc(NS(=O)(=O)c2ccc(Oc3cccc(Cl)c3C#N)cc2)c1
Show InChI InChI=1S/C19H14ClN3O3S/c1-13-9-10-22-19(11-13)23-27(24,25)15-7-5-14(6-8-15)26-18-4-2-3-17(20)16(18)12-21/h2-11H,1H3,(H,22,23)
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n/an/a>1.00E+4n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165880
PNG
(US9067922, 219)
Show SMILES Clc1cccc(Oc2ccc(cc2)S(=O)(=O)Nc2cccnc2)c1C#N
Show InChI InChI=1S/C18H12ClN3O3S/c19-17-4-1-5-18(16(17)11-20)25-14-6-8-15(9-7-14)26(23,24)22-13-3-2-10-21-12-13/h1-10,12,22H
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n/an/a>1.00E+4n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165891
PNG
(US9067922, 230)
Show SMILES Fc1ccc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(cn2)C#N)cc1Cl
Show InChI InChI=1S/C19H10ClFN4O3S/c20-16-8-14(2-4-17(16)21)28-18-5-3-15(7-13(18)10-23)29(26,27)25-19-6-1-12(9-22)11-24-19/h1-8,11H,(H,24,25)
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n/an/a 62n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165893
PNG
(US9067922, 232)
Show SMILES Clc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(C#N)c(Cl)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C19H10Cl2N4O3S/c20-14-2-6-19(24-11-14)25-29(26,27)16-4-5-18(13(7-16)10-23)28-15-3-1-12(9-22)17(21)8-15/h1-8,11H,(H,24,25)
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n/an/a 12n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165894
PNG
(US9067922, 233)
Show SMILES Cc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(C#N)c(Cl)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C20H13ClN4O3S/c1-13-2-7-20(24-12-13)25-29(26,27)17-5-6-19(15(8-17)11-23)28-16-4-3-14(10-22)18(21)9-16/h2-9,12H,1H3,(H,24,25)
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n/an/a 233n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165905
PNG
(US9067922, 247)
Show SMILES OCc1ccc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc1Cl
Show InChI InChI=1S/C19H13ClFN3O4S/c20-17-8-15(3-1-12(17)11-25)28-18-5-4-16(7-13(18)9-22)29(26,27)24-19-6-2-14(21)10-23-19/h1-8,10,25H,11H2,(H,23,24)
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n/an/a 1n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165670
PNG
(US9067922, 4)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3cc(ccc3F)C(F)(F)F)c(c2)C#N)nc1
Show InChI InChI=1S/C19H10F5N3O3S/c20-13-2-6-18(26-10-13)27-31(28,29)14-3-5-16(11(7-14)9-25)30-17-8-12(19(22,23)24)1-4-15(17)21/h1-8,10H,(H,26,27)
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n/an/a>1.00E+4n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165675
PNG
(US9067922, 9)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccccc3Cl)c(c2)C#N)nc1
Show InChI InChI=1S/C18H11ClFN3O3S/c19-15-3-1-2-4-17(15)26-16-7-6-14(9-12(16)10-21)27(24,25)23-18-8-5-13(20)11-22-18/h1-9,11H,(H,22,23)
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n/an/a 208n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165682
PNG
(US9067922, 16)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3cccc(F)c3F)c(c2)C#N)nc1
Show InChI InChI=1S/C18H10F3N3O3S/c19-12-4-7-17(23-10-12)24-28(25,26)13-5-6-15(11(8-13)9-22)27-16-3-1-2-14(20)18(16)21/h1-8,10H,(H,23,24)
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n/an/a 218n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165692
PNG
(US9067922, 26)
Show SMILES Cc1cc(Cl)c(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc1C#N
Show InChI InChI=1S/C20H12ClFN4O3S/c1-12-6-17(21)19(8-13(12)9-23)29-18-4-3-16(7-14(18)10-24)30(27,28)26-20-5-2-15(22)11-25-20/h2-8,11H,1H3,(H,25,26)
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n/an/a 57n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165697
PNG
(US9067922, 31)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(F)cc3Cl)c(c2)C#N)nc1
Show InChI InChI=1S/C18H10ClF2N3O3S/c19-15-8-12(20)1-4-17(15)27-16-5-3-14(7-11(16)9-22)28(25,26)24-18-6-2-13(21)10-23-18/h1-8,10H,(H,23,24)
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n/an/a 78n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165701
PNG
(US9067922, 35)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(OC(F)(F)F)cc3)c(c2)C#N)nc1
Show InChI InChI=1S/C19H11F4N3O4S/c20-13-1-8-18(25-11-13)26-31(27,28)16-6-7-17(12(9-16)10-24)29-14-2-4-15(5-3-14)30-19(21,22)23/h1-9,11H,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165709
PNG
(US9067922, 43)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(C#N)c(F)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C19H10F2N4O3S/c20-14-2-6-19(24-11-14)25-29(26,27)16-4-5-18(13(7-16)10-23)28-15-3-1-12(9-22)17(21)8-15/h1-8,11H,(H,24,25)
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n/an/a 53n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165711
PNG
(US9067922, 45)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(Cl)cc3C#N)c(c2)C#N)nc1
Show InChI InChI=1S/C19H10ClFN4O3S/c20-14-1-4-17(12(7-14)9-22)28-18-5-3-16(8-13(18)10-23)29(26,27)25-19-6-2-15(21)11-24-19/h1-8,11H,(H,24,25)
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n/an/a 174n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165718
PNG
(US9067922, 52)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3cccc(F)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C18H11F2N3O3S/c19-13-2-1-3-15(9-13)26-17-6-5-16(8-12(17)10-21)27(24,25)23-18-7-4-14(20)11-22-18/h1-9,11H,(H,22,23)
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n/an/a 259n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165741
PNG
(US9067922, 75)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3cccc(C#N)c3F)c(c2)C#N)nc1
Show InChI InChI=1S/C19H10F2N4O3S/c20-14-4-7-18(24-11-14)25-29(26,27)15-5-6-16(13(8-15)10-23)28-17-3-1-2-12(9-22)19(17)21/h1-8,11H,(H,24,25)
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n/an/a 2.21E+3n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165742
PNG
(US9067922, 76)
Show SMILES COc1cc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)ccc1C#N
Show InChI InChI=1S/C20H13FN4O4S/c1-28-19-9-16(4-2-13(19)10-22)29-18-6-5-17(8-14(18)11-23)30(26,27)25-20-7-3-15(21)12-24-20/h2-9,12H,1H3,(H,24,25)
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n/an/a 57n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165744
PNG
(US9067922, 78)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(F)c(Cl)c3)c(c2)C#N)nc1
Show InChI InChI=1S/C18H10ClF2N3O3S/c19-15-8-13(2-4-16(15)21)27-17-5-3-14(7-11(17)9-22)28(25,26)24-18-6-1-12(20)10-23-18/h1-8,10H,(H,23,24)
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n/an/a 19n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165757
PNG
(US9067922, 92)
Show SMILES Clc1cc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2cccnc2)ccc1C#N
Show InChI InChI=1S/C19H11ClN4O3S/c20-18-9-16(4-3-13(18)10-21)27-19-6-5-17(8-14(19)11-22)28(25,26)24-15-2-1-7-23-12-15/h1-9,12,24H
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n/an/a 414n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165759
PNG
(US9067922, 94)
Show SMILES Clc1cc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccnnc2)ccc1C#N
Show InChI InChI=1S/C18H10ClN5O3S/c19-17-8-15(2-1-12(17)9-20)27-18-4-3-16(7-13(18)10-21)28(25,26)24-14-5-6-22-23-11-14/h1-8,11H,(H,22,24)
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n/an/a>1.00E+4n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165780
PNG
(US9067922, 115)
Show SMILES COc1cccc(C)c1Oc1ccc(cc1C#N)S(=O)(=O)Nc1ccc(F)cn1
Show InChI InChI=1S/C20H16FN3O4S/c1-13-4-3-5-18(27-2)20(13)28-17-8-7-16(10-14(17)11-22)29(25,26)24-19-9-6-15(21)12-23-19/h3-10,12H,1-2H3,(H,23,24)
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n/an/a 24n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165802
PNG
(US9067922, 137)
Show SMILES CC(C)(C)c1ccc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc1
Show InChI InChI=1S/C22H20FN3O3S/c1-22(2,3)16-4-7-18(8-5-16)29-20-10-9-19(12-15(20)13-24)30(27,28)26-21-11-6-17(23)14-25-21/h4-12,14H,1-3H3,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165807
PNG
(US9067922, 142)
Show SMILES COc1ccccc1Oc1ccc(cc1C#N)S(=O)(=O)Nc1ccc(F)cn1
Show InChI InChI=1S/C19H14FN3O4S/c1-26-17-4-2-3-5-18(17)27-16-8-7-15(10-13(16)11-21)28(24,25)23-19-9-6-14(20)12-22-19/h2-10,12H,1H3,(H,22,23)
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n/an/a 75n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165813
PNG
(US9067922, 148)
Show SMILES COc1ccc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc1Cl
Show InChI InChI=1S/C19H13ClFN3O4S/c1-27-18-5-3-14(9-16(18)20)28-17-6-4-15(8-12(17)10-22)29(25,26)24-19-7-2-13(21)11-23-19/h2-9,11H,1H3,(H,23,24)
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n/an/a 53n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))		BDBM165825
PNG
(US9067922, 160)
Show SMILES COc1cc(F)ccc1Oc1ccc(cc1C#N)S(=O)(=O)Nc1ccc(F)cn1
Show InChI InChI=1S/C19H13F2N3O4S/c1-27-18-9-13(20)2-5-17(18)28-16-6-4-15(8-12(16)10-22)29(25,26)24-19-7-3-14(21)11-23-19/h2-9,11H,1H3,(H,23,24)
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n/an/a>1.00E+4n/an/an/an/a7.4n/a



Pfizer Limited

US Patent


Assay Description
Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ...

US Patent US9067922 (2015)


BindingDB Entry DOI: 10.7270/Q2VQ31F0
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 243 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%