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Patent code US9169260

Compile Data Set for Download or QSAR

Found 399 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188747
PNG
(US9169260, 13)
Show SMILES FC(F)(F)Oc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCNCC1
Show InChI InChI=1S/C22H20F3N7O2/c23-22(24,25)34-16-4-2-15(3-5-16)32-19(12-18(30-32)14-6-9-26-10-7-14)29-21(33)17-13-28-31-11-1-8-27-20(17)31/h1-5,8,11-14,26H,6-7,9-10H2,(H,29,33)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188751
PNG
(US9169260, 17)
Show SMILES Cc1cccc(c1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C23H25N7O3S/c1-16-5-3-6-18(13-16)30-21(26-23(31)19-15-25-29-10-4-9-24-22(19)29)14-20(27-30)17-7-11-28(12-8-17)34(2,32)33/h3-6,9-10,13-15,17H,7-8,11-12H2,1-2H3,(H,26,31)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188757
PNG
(US9169260, 23)
Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)S(=O)(=O)C(C)C
Show InChI InChI=1S/C25H29N7O4S/c1-17(2)37(34,35)30-13-9-18(10-14-30)22-15-23(32(29-22)19-5-7-20(36-3)8-6-19)28-25(33)21-16-27-31-12-4-11-26-24(21)31/h4-8,11-12,15-18H,9-10,13-14H2,1-3H3,(H,28,33)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188759
PNG
(US9169260, 25)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)S(=O)(=O)C1CCCC1
Show InChI InChI=1S/C27H31N7O3S/c1-19-7-9-21(10-8-19)34-25(30-27(35)23-18-29-33-14-4-13-28-26(23)33)17-24(31-34)20-11-15-32(16-12-20)38(36,37)22-5-2-3-6-22/h4,7-10,13-14,17-18,20,22H,2-3,5-6,11-12,15-16H2,1H3,(H,30,35)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188768
PNG
(US9169260, 34)
Show SMILES Cc1ccc(cc1)-c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(F)cc1F
Show InChI InChI=1S/C23H16F2N6O/c1-14-3-5-15(6-4-14)19-12-21(31(29-19)20-8-7-16(24)11-18(20)25)28-23(32)17-13-27-30-10-2-9-26-22(17)30/h2-13H,1H3,(H,28,32)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188773
PNG
(US9169260, 325 | US9169260, 39)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)C1CCCC1
Show InChI InChI=1S/C27H31N7O/c1-19-7-9-22(10-8-19)34-25(30-27(35)23-18-29-33-14-4-13-28-26(23)33)17-24(31-34)20-11-15-32(16-12-20)21-5-2-3-6-21/h4,7-10,13-14,17-18,20-21H,2-3,5-6,11-12,15-16H2,1H3,(H,30,35)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188777
PNG
(US9169260, 43)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCCN(C1)S(C)(=O)=O
Show InChI InChI=1S/C23H25N7O3S/c1-16-6-8-18(9-7-16)30-21(26-23(31)19-14-25-29-12-4-10-24-22(19)29)13-20(27-30)17-5-3-11-28(15-17)34(2,32)33/h4,6-10,12-14,17H,3,5,11,15H2,1-2H3,(H,26,31)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188783
PNG
(US9169260, 49)
Show SMILES Fc1ccc(c(F)c1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)C1CCC1
Show InChI InChI=1S/C25H25F2N7O/c26-17-5-6-22(20(27)13-17)34-23(30-25(35)19-15-29-33-10-2-9-28-24(19)33)14-21(31-34)16-7-11-32(12-8-16)18-3-1-4-18/h2,5-6,9-10,13-16,18H,1,3-4,7-8,11-12H2,(H,30,35)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188789
PNG
(US9169260, 55)
Show SMILES CC(C)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(cc1)C1CC1
Show InChI InChI=1S/C27H31N7O/c1-18(2)32-14-10-21(11-15-32)24-16-25(30-27(35)23-17-29-33-13-3-12-28-26(23)33)34(31-24)22-8-6-20(7-9-22)19-4-5-19/h3,6-9,12-13,16-19,21H,4-5,10-11,14-15H2,1-2H3,(H,30,35)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188795
PNG
(US9169260, 61)
Show SMILES COc1ccc(c(F)c1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCNCC1
Show InChI InChI=1S/C22H22FN7O2/c1-32-15-3-4-19(17(23)11-15)30-20(12-18(28-30)14-5-8-24-9-6-14)27-22(31)16-13-26-29-10-2-7-25-21(16)29/h2-4,7,10-14,24H,5-6,8-9H2,1H3,(H,27,31)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188799
PNG
(US9169260, 65)
Show SMILES Cc1ccc(c(Cl)c1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCNCC1
Show InChI InChI=1S/C22H22ClN7O/c1-14-3-4-19(17(23)11-14)30-20(12-18(28-30)15-5-8-24-9-6-15)27-22(31)16-13-26-29-10-2-7-25-21(16)29/h2-4,7,10-13,15,24H,5-6,8-9H2,1H3,(H,27,31)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188803
PNG
(US9169260, 69)
Show SMILES CC(C)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(F)cc1C
Show InChI InChI=1S/C25H28FN7O/c1-16(2)31-11-7-18(8-12-31)21-14-23(33(30-21)22-6-5-19(26)13-17(22)3)29-25(34)20-15-28-32-10-4-9-27-24(20)32/h4-6,9-10,13-16,18H,7-8,11-12H2,1-3H3,(H,29,34)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188810
PNG
(US9169260, 76)
Show SMILES Fc1cc(ccc1-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC(F)(F)F)CC1)C1CC1
Show InChI InChI=1S/C26H25F4N7O/c27-20-12-18(16-2-3-16)4-5-22(20)37-23(33-25(38)19-14-32-36-9-1-8-31-24(19)36)13-21(34-37)17-6-10-35(11-7-17)15-26(28,29)30/h1,4-5,8-9,12-14,16-17H,2-3,6-7,10-11,15H2,(H,33,38)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188827
PNG
(US9169260, 93)
Show SMILES CC1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1 |(-1.1,-6.57,;-.7,-5.09,;-1.78,-3.95,;-1.38,-2.46,;.11,-2.06,;1.2,-3.15,;.8,-4.64,;.51,-.57,;-.4,.67,;.51,1.92,;.11,3.41,;-1.38,3.81,;-2.47,2.72,;-1.78,5.29,;-1.3,6.76,;-2.55,7.66,;-3.79,6.76,;-5.3,7.08,;-6.33,5.93,;-5.85,4.47,;-4.35,4.15,;-3.32,5.29,;1.97,1.44,;1.97,-.1,;3.06,2.53,;4.55,2.13,;5.64,3.22,;5.24,4.71,;6.33,5.8,;3.75,5.11,;2.66,4.02,)|
Show InChI InChI=1S/C24H26N6O/c1-16-4-8-18(9-5-16)21-14-22(30(28-21)19-10-6-17(2)7-11-19)27-24(31)20-15-26-29-13-3-12-25-23(20)29/h3,6-7,10-16,18H,4-5,8-9H2,1-2H3,(H,27,31)
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n/an/a>1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188831
PNG
(US9169260, 97)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCC(CC1)C(F)(F)F |(6.33,5.23,;5.24,4.14,;5.64,2.65,;4.55,1.56,;3.06,1.96,;2.66,3.45,;3.75,4.54,;1.97,.87,;1.97,-.67,;.51,-1.14,;-.4,.1,;.51,1.35,;.11,2.84,;-1.38,3.24,;-2.47,2.15,;-1.78,4.72,;-1.3,6.19,;-2.55,7.09,;-3.79,6.19,;-5.3,6.51,;-6.33,5.36,;-5.85,3.9,;-4.35,3.58,;-3.32,4.72,;.11,-2.63,;-1.38,-3.03,;-1.78,-4.52,;-.69,-5.61,;.8,-5.21,;1.2,-3.72,;-1.09,-7.09,;-1.48,-8.58,;-2.57,-6.69,;.4,-7.49,)|
Show InChI InChI=1S/C24H23F3N6O/c1-15-3-9-18(10-4-15)33-21(30-23(34)19-14-29-32-12-2-11-28-22(19)32)13-20(31-33)16-5-7-17(8-6-16)24(25,26)27/h2-4,9-14,16-17H,5-8H2,1H3,(H,30,34)
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n/an/a>1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188834
PNG
(US9169260, 100)
Show SMILES Cc1ccc(cc1)-c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1F
Show InChI InChI=1S/C24H19FN6O/c1-15-4-7-17(8-5-15)20-13-22(31(29-20)21-9-6-16(2)12-19(21)25)28-24(32)18-14-27-30-11-3-10-26-23(18)30/h3-14H,1-2H3,(H,28,32)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188853
PNG
(US9169260, 119)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cc(Br)cnc12)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C23H24BrN7O3S/c1-15-3-5-18(6-4-15)31-21(11-20(28-31)16-7-9-29(10-8-16)35(2,33)34)27-23(32)19-13-26-30-14-17(24)12-25-22(19)30/h3-6,11-14,16H,7-10H2,1-2H3,(H,27,32)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188857
PNG
(US9169260, 123)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)-c1cccnc1
Show InChI InChI=1S/C22H17N7O/c1-15-5-7-17(8-6-15)29-20(12-19(27-29)16-4-2-9-23-13-16)26-22(30)18-14-25-28-11-3-10-24-21(18)28/h2-14H,1H3,(H,26,30)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188866
PNG
(US9169260, 132)
Show SMILES COc1ccc(cc1)-c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1cccc(F)c1
Show InChI InChI=1S/C23H17FN6O2/c1-32-18-8-6-15(7-9-18)20-13-21(30(28-20)17-5-2-4-16(24)12-17)27-23(31)19-14-26-29-11-3-10-25-22(19)29/h2-14H,1H3,(H,27,31)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188881
PNG
(US9169260, 147)
Show SMILES CN1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(cn1)C1CC1
Show InChI InChI=1S/C24H26N8O/c1-30-11-7-17(8-12-30)20-13-22(28-24(33)19-15-27-31-10-2-9-25-23(19)31)32(29-20)21-6-5-18(14-26-21)16-3-4-16/h2,5-6,9-10,13-17H,3-4,7-8,11-12H2,1H3,(H,28,33)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188910
PNG
(US9169260, 176)
Show SMILES CC1(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(CN)cn1
Show InChI InChI=1S/C20H20N8O/c1-20(5-6-20)15-9-17(28(26-15)16-4-3-13(10-21)11-23-16)25-19(29)14-12-24-27-8-2-7-22-18(14)27/h2-4,7-9,11-12H,5-6,10,21H2,1H3,(H,25,29)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188914
PNG
(US9169260, 180)
Show SMILES Cc1ccc(nc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CC1
Show InChI InChI=1S/C19H17N7O/c1-12-3-6-16(21-10-12)26-17(9-15(24-26)13-4-5-13)23-19(27)14-11-22-25-8-2-7-20-18(14)25/h2-3,6-11,13H,4-5H2,1H3,(H,23,27)
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n/an/a>1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188915
PNG
(US9169260, 181)
Show SMILES Cc1ccc(nc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1(C)CC1
Show InChI InChI=1S/C20H19N7O/c1-13-4-5-16(22-11-13)27-17(10-15(25-27)20(2)6-7-20)24-19(28)14-12-23-26-9-3-8-21-18(14)26/h3-5,8-12H,6-7H2,1-2H3,(H,24,28)
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n/an/a>1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188917
PNG
(US9169260, 183)
Show SMILES COC(=O)NCC1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cn1 |(-4.86,-9.98,;-4.46,-8.49,;-2.97,-8.09,;-1.88,-9.18,;-2.57,-6.6,;-1.09,-6.2,;-.69,-4.72,;-1.78,-3.63,;-1.38,-2.14,;.11,-1.74,;1.2,-2.83,;.8,-4.32,;.51,-.25,;-.4,.99,;.51,2.24,;.11,3.73,;-1.38,4.12,;-2.47,3.04,;-1.78,5.61,;-1.3,7.08,;-2.55,7.98,;-3.79,7.08,;-5.3,7.4,;-6.33,6.25,;-5.85,4.79,;-4.35,4.47,;-3.32,5.61,;1.97,1.76,;1.97,.22,;3.06,2.85,;2.66,4.34,;3.75,5.43,;5.24,5.03,;6.33,6.12,;5.64,3.54,;4.55,2.45,)|
Show InChI InChI=1S/C25H28N8O3/c1-16-4-9-21(27-13-16)33-22(30-24(34)19-15-29-32-11-3-10-26-23(19)32)12-20(31-33)18-7-5-17(6-8-18)14-28-25(35)36-2/h3-4,9-13,15,17-18H,5-8,14H2,1-2H3,(H,28,35)(H,30,34)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188923
PNG
(US9169260, 189)
Show SMILES O=C(Nc1cc(nn1-c1nccs1)C1CCNCC1)c1cnn2cccnc12
Show InChI InChI=1S/C18H18N8OS/c27-17(13-11-22-25-8-1-4-20-16(13)25)23-15-10-14(12-2-5-19-6-3-12)24-26(15)18-21-7-9-28-18/h1,4,7-12,19H,2-3,5-6H2,(H,23,27)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188929
PNG
(US9169260, 195)
Show SMILES Cc1ccc(cc1)-c1cc(NC(=O)c2cnn3cc(cnc23)C2CC2)n(n1)-c1ccc(C)cn1
Show InChI InChI=1S/C26H23N7O/c1-16-3-6-19(7-4-16)22-11-24(33(31-22)23-10-5-17(2)12-27-23)30-26(34)21-14-29-32-15-20(18-8-9-18)13-28-25(21)32/h3-7,10-15,18H,8-9H2,1-2H3,(H,30,34)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188939
PNG
(US9169260, 205)
Show SMILES CN1CCC(CC1)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C28H34N8O/c1-20-4-6-23(7-5-20)36-26(31-28(37)24-19-30-35-13-3-12-29-27(24)35)18-25(32-36)21-8-16-34(17-9-21)22-10-14-33(2)15-11-22/h3-7,12-13,18-19,21-22H,8-11,14-17H2,1-2H3,(H,31,37)
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n/an/a>1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188959
PNG
(US9169260, 225)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(Cc2cccnc2)CC1
Show InChI InChI=1S/C28H28N8O/c1-20-5-7-23(8-6-20)36-26(32-28(37)24-18-31-35-13-3-12-30-27(24)35)16-25(33-36)22-9-14-34(15-10-22)19-21-4-2-11-29-17-21/h2-8,11-13,16-18,22H,9-10,14-15,19H2,1H3,(H,32,37)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188987
PNG
(US9169260, 253)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)C1CCC(CC1)C#N |(8.54,2,;7.05,1.6,;6.65,.12,;5.16,-.28,;4.08,.81,;4.47,2.3,;5.96,2.69,;2.59,.41,;2.11,-1.06,;.57,-1.06,;.1,.41,;1.34,1.31,;1.34,2.85,;.01,3.62,;-1.33,2.85,;.01,5.16,;1.25,6.07,;.78,7.53,;-.76,7.53,;-1.79,8.68,;-3.3,8.36,;-3.77,6.89,;-2.74,5.75,;-1.24,6.07,;-.52,-2.14,;-2,-1.75,;-3.09,-2.84,;-2.69,-4.32,;-1.21,-4.72,;-.12,-3.63,;-3.78,-5.41,;-5.27,-5.01,;-6.36,-6.1,;-5.96,-7.59,;-4.47,-7.99,;-3.39,-6.9,;-7.05,-8.68,;-8.54,-8.28,)|
Show InChI InChI=1S/C29H32N8O/c1-20-3-7-24(8-4-20)37-27(33-29(38)25-19-32-36-14-2-13-31-28(25)36)17-26(34-37)22-11-15-35(16-12-22)23-9-5-21(18-30)6-10-23/h2-4,7-8,13-14,17,19,21-23H,5-6,9-12,15-16H2,1H3,(H,33,38)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188998
PNG
(US9169260, 264)
Show SMILES Cc1ccc(nc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)C1CCCOC1
Show InChI InChI=1S/C26H30N8O2/c1-18-5-6-23(28-15-18)34-24(30-26(35)21-16-29-33-10-3-9-27-25(21)33)14-22(31-34)19-7-11-32(12-8-19)20-4-2-13-36-17-20/h3,5-6,9-10,14-16,19-20H,2,4,7-8,11-13,17H2,1H3,(H,30,35)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188999
PNG
(US9169260, 265)
Show SMILES Cc1ccc(nc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)C1CCC(CC1)C#N |(7.79,2.75,;6.31,2.35,;5.91,.86,;4.42,.46,;3.33,1.55,;3.73,3.04,;5.22,3.44,;1.84,1.15,;1.37,-.31,;-.17,-.31,;-.65,1.15,;.6,2.06,;.6,3.6,;-.74,4.37,;-2.07,3.6,;-.74,5.91,;.51,6.81,;.03,8.28,;-1.51,8.28,;-2.54,9.42,;-4.04,9.1,;-4.52,7.64,;-3.49,6.49,;-1.98,6.81,;-1.26,-1.4,;-2.75,-1,;-3.84,-2.09,;-3.44,-3.58,;-1.95,-3.98,;-.86,-2.89,;-4.53,-4.67,;-6.01,-4.27,;-7.1,-5.36,;-6.71,-6.85,;-5.22,-7.24,;-4.13,-6.16,;-7.79,-7.93,;-7.4,-9.42,)|
Show InChI InChI=1S/C28H31N9O/c1-19-3-8-25(31-17-19)37-26(33-28(38)23-18-32-36-12-2-11-30-27(23)36)15-24(34-37)21-9-13-35(14-10-21)22-6-4-20(16-29)5-7-22/h2-3,8,11-12,15,17-18,20-22H,4-7,9-10,13-14H2,1H3,(H,33,38)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189001
PNG
(US9169260, 267)
Show SMILES Cc1ccc(nc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)C1CCN(CC1)C1CC1
Show InChI InChI=1S/C29H35N9O/c1-20-3-6-26(31-18-20)38-27(33-29(39)24-19-32-37-12-2-11-30-28(24)37)17-25(34-38)21-7-13-35(14-8-21)23-9-15-36(16-10-23)22-4-5-22/h2-3,6,11-12,17-19,21-23H,4-5,7-10,13-16H2,1H3,(H,33,39)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189003
PNG
(US9169260, 269)
Show SMILES CN(C)C1CC(C1)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cn1 |(-5.39,-9.44,;-6.16,-8.11,;-7.7,-8.11,;-5.39,-6.78,;-5.79,-5.29,;-4.3,-4.89,;-3.9,-6.38,;-3.53,-3.56,;-3.93,-2.07,;-2.84,-.98,;-1.35,-1.38,;-.96,-2.87,;-2.04,-3.96,;-.27,-.29,;-.74,1.17,;.5,2.08,;.5,3.62,;-.83,4.39,;-2.16,3.62,;-.83,5.93,;.42,6.83,;-.06,8.3,;-1.6,8.3,;-2.63,9.44,;-4.14,9.12,;-4.61,7.66,;-3.58,6.51,;-2.07,6.83,;1.75,1.17,;1.27,-.29,;3.24,1.57,;4.33,.48,;5.81,.88,;6.21,2.37,;7.7,2.77,;5.12,3.46,;3.64,3.06,)|
Show InChI InChI=1S/C27H33N9O/c1-18-5-6-24(29-16-18)36-25(31-27(37)22-17-30-35-10-4-9-28-26(22)35)15-23(32-36)19-7-11-34(12-8-19)21-13-20(14-21)33(2)3/h4-6,9-10,15-17,19-21H,7-8,11-14H2,1-3H3,(H,31,37)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189007
PNG
(US9169260, 273)
Show SMILES C[C@@H]1CCC(C1)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cn1 |r|
Show InChI InChI=1S/C27H32N8O/c1-18-4-6-21(14-18)33-12-8-20(9-13-33)23-15-25(35(32-23)24-7-5-19(2)16-29-24)31-27(36)22-17-30-34-11-3-10-28-26(22)34/h3,5,7,10-11,15-18,20-21H,4,6,8-9,12-14H2,1-2H3,(H,31,36)/t18-,21?/m1/s1
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189012
PNG
(US9169260, 278)
Show SMILES CC(C)CN1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cn1
Show InChI InChI=1S/C25H30N8O/c1-17(2)16-31-11-7-19(8-12-31)21-13-23(33(30-21)22-6-5-18(3)14-27-22)29-25(34)20-15-28-32-10-4-9-26-24(20)32/h4-6,9-10,13-15,17,19H,7-8,11-12,16H2,1-3H3,(H,29,34)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189016
PNG
(US9169260, 282)
Show SMILES Cc1ccc(nc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)C1Cc2ccccc2C1
Show InChI InChI=1S/C30H30N8O/c1-20-7-8-27(32-18-20)38-28(34-30(39)25-19-33-37-12-4-11-31-29(25)37)17-26(35-38)21-9-13-36(14-10-21)24-15-22-5-2-3-6-23(22)16-24/h2-8,11-12,17-19,21,24H,9-10,13-16H2,1H3,(H,34,39)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189017
PNG
(US9169260, 283)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCCN(CC2CCOC2)C1
Show InChI InChI=1S/C27H31N7O2/c1-19-5-7-22(8-6-19)34-25(30-27(35)23-15-29-33-12-3-10-28-26(23)33)14-24(31-34)21-4-2-11-32(17-21)16-20-9-13-36-18-20/h3,5-8,10,12,14-15,20-21H,2,4,9,11,13,16-18H2,1H3,(H,30,35)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189023
PNG
(US9169260, 289)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCCN(Cc2ncco2)C1
Show InChI InChI=1S/C26H26N8O2/c1-18-5-7-20(8-6-18)34-23(30-26(35)21-15-29-33-12-3-9-28-25(21)33)14-22(31-34)19-4-2-11-32(16-19)17-24-27-10-13-36-24/h3,5-10,12-15,19H,2,4,11,16-17H2,1H3,(H,30,35)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189025
PNG
(US9169260, 291)
Show SMILES COc1ncc(CN2CCCC(C2)c2cc(NC(=O)c3cnn4cccnc34)n(n2)-c2ccc(C)cc2)cn1
Show InChI InChI=1S/C28H29N9O2/c1-19-6-8-22(9-7-19)37-25(33-27(38)23-16-32-36-12-4-10-29-26(23)36)13-24(34-37)21-5-3-11-35(18-21)17-20-14-30-28(39-2)31-15-20/h4,6-10,12-16,21H,3,5,11,17-18H2,1-2H3,(H,33,38)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189033
PNG
(US9169260, 299)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCCN(Cc2ccncc2)C1
Show InChI InChI=1S/C28H28N8O/c1-20-5-7-23(8-6-20)36-26(32-28(37)24-17-31-35-15-3-11-30-27(24)35)16-25(33-36)22-4-2-14-34(19-22)18-21-9-12-29-13-10-21/h3,5-13,15-17,22H,2,4,14,18-19H2,1H3,(H,32,37)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189034
PNG
(US9169260, 300)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCCN(Cc2cccnc2)C1
Show InChI InChI=1S/C28H28N8O/c1-20-7-9-23(10-8-20)36-26(32-28(37)24-17-31-35-14-4-12-30-27(24)35)15-25(33-36)22-6-3-13-34(19-22)18-21-5-2-11-29-16-21/h2,4-5,7-12,14-17,22H,3,6,13,18-19H2,1H3,(H,32,37)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189051
PNG
(US9169260, 317)
Show SMILES COc1ncc(CN2CC(C2)c2cc(NC(=O)c3cnn4cccnc34)n(n2)-c2ccc(C)cc2)cn1
Show InChI InChI=1S/C26H25N9O2/c1-17-4-6-20(7-5-17)35-23(31-25(36)21-13-30-34-9-3-8-27-24(21)34)10-22(32-35)19-15-33(16-19)14-18-11-28-26(37-2)29-12-18/h3-13,19H,14-16H2,1-2H3,(H,31,36)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188773
PNG
(US9169260, 325 | US9169260, 39)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)C1CCCC1
Show InChI InChI=1S/C27H31N7O/c1-19-7-9-22(10-8-19)34-25(30-27(35)23-18-29-33-14-4-13-28-26(23)33)17-24(31-34)20-11-15-32(16-12-20)21-5-2-3-6-21/h4,7-10,13-14,17-18,20-21H,2-3,5-6,11-12,15-16H2,1H3,(H,30,35)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189057
PNG
(US9169260, 326)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)-c1cnn(C)c1
Show InChI InChI=1S/C21H18N8O/c1-14-4-6-16(7-5-14)29-19(10-18(26-29)15-11-23-27(2)13-15)25-21(30)17-12-24-28-9-3-8-22-20(17)28/h3-13H,1-2H3,(H,25,30)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189071
PNG
(US9169260, 340)
Show SMILES CCN(CC)S(=O)(=O)c1ccc(-c2cc(NC(=O)c3cnn4cccnc34)n(n2)-c2ccc(C)cc2)c(C)c1
Show InChI InChI=1S/C28H29N7O3S/c1-5-33(6-2)39(37,38)22-12-13-23(20(4)16-22)25-17-26(35(32-25)21-10-8-19(3)9-11-21)31-28(36)24-18-30-34-15-7-14-29-27(24)34/h7-18H,5-6H2,1-4H3,(H,31,36)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189083
PNG
(US9169260, 352)
Show SMILES CCS(=O)(=O)c1ccc(cc1)-c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C25H22N6O3S/c1-3-35(33,34)20-11-7-18(8-12-20)22-15-23(31(29-22)19-9-5-17(2)6-10-19)28-25(32)21-16-27-30-14-4-13-26-24(21)30/h4-16H,3H2,1-2H3,(H,28,32)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189092
PNG
(US9169260, 361)
Show SMILES CCCS(=O)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C25H29N7O2S/c1-3-15-35(34)30-13-9-19(10-14-30)22-16-23(32(29-22)20-7-5-18(2)6-8-20)28-25(33)21-17-27-31-12-4-11-26-24(21)31/h4-8,11-12,16-17,19H,3,9-10,13-15H2,1-2H3,(H,28,33)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189104
PNG
(US9169260, 373)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)S(=O)C1CCCCC1
Show InChI InChI=1S/C28H33N7O2S/c1-20-8-10-22(11-9-20)35-26(31-28(36)24-19-30-34-15-5-14-29-27(24)34)18-25(32-35)21-12-16-33(17-13-21)38(37)23-6-3-2-4-7-23/h5,8-11,14-15,18-19,21,23H,2-4,6-7,12-13,16-17H2,1H3,(H,31,36)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189105
PNG
(US9169260, 374)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)S(=O)c1cccc(c1)C#N
Show InChI InChI=1S/C29H26N8O2S/c1-20-6-8-23(9-7-20)37-27(33-29(38)25-19-32-36-13-3-12-31-28(25)36)17-26(34-37)22-10-14-35(15-11-22)40(39)24-5-2-4-21(16-24)18-30/h2-9,12-13,16-17,19,22H,10-11,14-15H2,1H3,(H,33,38)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189119
PNG
(US9169260, 388)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)S(=O)c1cccnc1Cl
Show InChI InChI=1S/C27H25ClN8O2S/c1-18-5-7-20(8-6-18)36-24(32-27(37)21-17-31-35-13-3-12-30-26(21)35)16-22(33-36)19-9-14-34(15-10-19)39(38)23-4-2-11-29-25(23)28/h2-8,11-13,16-17,19H,9-10,14-15H2,1H3,(H,32,37)
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US Patent
n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%