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Patent code US9169260

Compile Data Set for Download or QSAR

Found 399 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188740
PNG
(US9169260, 6)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCC(O)CC1 |(6.33,5.23,;5.24,4.14,;5.64,2.65,;4.55,1.56,;3.06,1.96,;2.66,3.45,;3.75,4.54,;1.97,.87,;1.97,-.67,;.51,-1.14,;-.4,.1,;.51,1.35,;.11,2.84,;-1.38,3.24,;-2.47,2.15,;-1.78,4.72,;-1.3,6.19,;-2.55,7.09,;-3.79,6.19,;-5.3,6.51,;-6.33,5.36,;-5.85,3.9,;-4.35,3.58,;-3.32,4.72,;.11,-2.63,;-1.38,-3.03,;-1.78,-4.52,;-.69,-5.61,;-1.09,-7.09,;.8,-5.21,;1.2,-3.72,)|
Show InChI InChI=1S/C23H24N6O2/c1-15-3-7-17(8-4-15)29-21(13-20(27-29)16-5-9-18(30)10-6-16)26-23(31)19-14-25-28-12-2-11-24-22(19)28/h2-4,7-8,11-14,16,18,30H,5-6,9-10H2,1H3,(H,26,31)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188741
PNG
(US9169260, 7)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCNCC1
Show InChI InChI=1S/C22H23N7O/c1-15-3-5-17(6-4-15)29-20(13-19(27-29)16-7-10-23-11-8-16)26-22(30)18-14-25-28-12-2-9-24-21(18)28/h2-6,9,12-14,16,23H,7-8,10-11H2,1H3,(H,26,30)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188748
PNG
(US9169260, 14)
Show SMILES Cc1ccccc1-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCNCC1
Show InChI InChI=1S/C22H23N7O/c1-15-5-2-3-6-19(15)29-20(13-18(27-29)16-7-10-23-11-8-16)26-22(30)17-14-25-28-12-4-9-24-21(17)28/h2-6,9,12-14,16,23H,7-8,10-11H2,1H3,(H,26,30)
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n/an/a>1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188759
PNG
(US9169260, 25)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)S(=O)(=O)C1CCCC1
Show InChI InChI=1S/C27H31N7O3S/c1-19-7-9-21(10-8-19)34-25(30-27(35)23-18-29-33-14-4-13-28-26(23)33)17-24(31-34)20-11-15-32(16-12-20)38(36,37)22-5-2-3-6-22/h4,7-10,13-14,17-18,20,22H,2-3,5-6,11-12,15-16H2,1H3,(H,30,35)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188762
PNG
(US9169260, 28)
Show SMILES CS(=O)(=O)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(F)cc1F
Show InChI InChI=1S/C22H21F2N7O3S/c1-35(33,34)29-9-5-14(6-10-29)18-12-20(31(28-18)19-4-3-15(23)11-17(19)24)27-22(32)16-13-26-30-8-2-7-25-21(16)30/h2-4,7-8,11-14H,5-6,9-10H2,1H3,(H,27,32)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188771
PNG
(US9169260, 37)
Show SMILES CC(C)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C25H29N7O/c1-17(2)30-13-9-19(10-14-30)22-15-23(32(29-22)20-7-5-18(3)6-8-20)28-25(33)21-16-27-31-12-4-11-26-24(21)31/h4-8,11-12,15-17,19H,9-10,13-14H2,1-3H3,(H,28,33)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188776
PNG
(US9169260, 42)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCCNC1
Show InChI InChI=1S/C22H23N7O/c1-15-5-7-17(8-6-15)29-20(12-19(27-29)16-4-2-9-23-13-16)26-22(30)18-14-25-28-11-3-10-24-21(18)28/h3,5-8,10-12,14,16,23H,2,4,9,13H2,1H3,(H,26,30)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188786
PNG
(US9169260, 52)
Show SMILES O=C(Nc1cc(nn1-c1ccc(cc1)C1CC1)C1CCNCC1)c1cnn2cccnc12
Show InChI InChI=1S/C24H25N7O/c32-24(20-15-27-30-13-1-10-26-23(20)30)28-22-14-21(18-8-11-25-12-9-18)29-31(22)19-6-4-17(5-7-19)16-2-3-16/h1,4-7,10,13-16,18,25H,2-3,8-9,11-12H2,(H,28,32)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188801
PNG
(US9169260, 67)
Show SMILES Fc1cc(F)cc(c1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCNCC1
Show InChI InChI=1S/C21H19F2N7O/c22-14-8-15(23)10-16(9-14)30-19(11-18(28-30)13-2-5-24-6-3-13)27-21(31)17-12-26-29-7-1-4-25-20(17)29/h1,4,7-13,24H,2-3,5-6H2,(H,27,31)
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n/an/a>1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188803
PNG
(US9169260, 69)
Show SMILES CC(C)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(F)cc1C
Show InChI InChI=1S/C25H28FN7O/c1-16(2)31-11-7-18(8-12-31)21-14-23(33(30-21)22-6-5-19(26)13-17(22)3)29-25(34)20-15-28-32-10-4-9-27-24(20)32/h4-6,9-10,13-16,18H,7-8,11-12H2,1-3H3,(H,29,34)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188823
PNG
(US9169260, 89)
Show SMILES Fc1cc(ccc1-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CN(C1)C1CCC1)C1CC1
Show InChI InChI=1S/C26H26FN7O/c27-21-11-17(16-5-6-16)7-8-23(21)34-24(12-22(31-34)18-14-32(15-18)19-3-1-4-19)30-26(35)20-13-29-33-10-2-9-28-25(20)33/h2,7-13,16,18-19H,1,3-6,14-15H2,(H,30,35)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188832
PNG
(US9169260, 98)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCS(=O)(=O)CC1
Show InChI InChI=1S/C22H22N6O3S/c1-15-3-5-17(6-4-15)28-20(13-19(26-28)16-7-11-32(30,31)12-8-16)25-22(29)18-14-24-27-10-2-9-23-21(18)27/h2-6,9-10,13-14,16H,7-8,11-12H2,1H3,(H,25,29)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188842
PNG
(US9169260, 108)
Show SMILES CC(C)N1CCC(CC1)c1cc(NC(=O)c2cnn3cc(Br)cnc23)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C25H28BrN7O/c1-16(2)31-10-8-18(9-11-31)22-12-23(33(30-22)20-6-4-17(3)5-7-20)29-25(34)21-14-28-32-15-19(26)13-27-24(21)32/h4-7,12-16,18H,8-11H2,1-3H3,(H,29,34)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188854
PNG
(US9169260, 120)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cc(NC=O)cnc12)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C24H26N8O4S/c1-16-3-5-19(6-4-16)32-22(11-21(29-32)17-7-9-30(10-8-17)37(2,35)36)28-24(34)20-13-27-31-14-18(26-15-33)12-25-23(20)31/h3-6,11-15,17H,7-10H2,1-2H3,(H,26,33)(H,28,34)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188857
PNG
(US9169260, 123)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)-c1cccnc1
Show InChI InChI=1S/C22H17N7O/c1-15-5-7-17(8-6-15)29-20(12-19(27-29)16-4-2-9-23-13-16)26-22(30)18-14-25-28-11-3-10-24-21(18)28/h2-14H,1H3,(H,26,30)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188863
PNG
(US9169260, 129)
Show SMILES COc1cc(ccn1)-c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C23H19N7O2/c1-15-4-6-17(7-5-15)30-20(13-19(28-30)16-8-10-24-21(12-16)32-2)27-23(31)18-14-26-29-11-3-9-25-22(18)29/h3-14H,1-2H3,(H,27,31)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188886
PNG
(US9169260, 152)
Show SMILES Cc1ccc(nc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCNCC1
Show InChI InChI=1S/C21H22N8O/c1-14-3-4-18(24-12-14)29-19(11-17(27-29)15-5-8-22-9-6-15)26-21(30)16-13-25-28-10-2-7-23-20(16)28/h2-4,7,10-13,15,22H,5-6,8-9H2,1H3,(H,26,30)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188891
PNG
(US9169260, 157)
Show SMILES CS(=O)(=O)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(CN)cn1
Show InChI InChI=1S/C22H25N9O3S/c1-35(33,34)29-9-5-16(6-10-29)18-11-20(31(28-18)19-4-3-15(12-23)13-25-19)27-22(32)17-14-26-30-8-2-7-24-21(17)30/h2-4,7-8,11,13-14,16H,5-6,9-10,12,23H2,1H3,(H,27,32)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188899
PNG
(US9169260, 165)
Show SMILES CS(=O)(=O)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C=O)cn1
Show InChI InChI=1S/C22H22N8O4S/c1-35(33,34)28-9-5-16(6-10-28)18-11-20(30(27-18)19-4-3-15(14-31)12-24-19)26-22(32)17-13-25-29-8-2-7-23-21(17)29/h2-4,7-8,11-14,16H,5-6,9-10H2,1H3,(H,26,32)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188904
PNG
(US9169260, 170)
Show SMILES Cc1cnc(nc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C21H23N9O3S/c1-14-11-23-21(24-12-14)30-18(26-20(31)16-13-25-29-7-3-6-22-19(16)29)10-17(27-30)15-4-8-28(9-5-15)34(2,32)33/h3,6-7,10-13,15H,4-5,8-9H2,1-2H3,(H,26,31)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188924
PNG
(US9169260, 190)
Show SMILES Cc1ccc(nc1)-n1nc(cc1NC(=O)c1cnn2cc(Br)cnc12)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C22H23BrN8O3S/c1-14-3-4-19(24-10-14)31-20(9-18(28-31)15-5-7-29(8-6-15)35(2,33)34)27-22(32)17-12-26-30-13-16(23)11-25-21(17)30/h3-4,9-13,15H,5-8H2,1-2H3,(H,27,32)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188935
PNG
(US9169260, 201)
Show SMILES CN1CCN(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(cn1)C1CC1
Show InChI InChI=1S/C23H25N9O/c1-29-9-11-30(12-10-29)21-13-20(27-23(33)18-15-26-31-8-2-7-24-22(18)31)32(28-21)19-6-5-17(14-25-19)16-3-4-16/h2,5-8,13-16H,3-4,9-12H2,1H3,(H,27,33)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188938
PNG
(US9169260, 204)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C28H33N7O/c1-20-8-10-23(11-9-20)35-26(31-28(36)24-19-30-34-15-5-14-29-27(24)34)18-25(32-35)21-12-16-33(17-13-21)22-6-3-2-4-7-22/h5,8-11,14-15,18-19,21-22H,2-4,6-7,12-13,16-17H2,1H3,(H,31,36)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188942
PNG
(US9169260, 208)
Show SMILES CC(C)C(C)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C27H33N7O/c1-18(2)20(4)32-14-10-21(11-15-32)24-16-25(34(31-24)22-8-6-19(3)7-9-22)30-27(35)23-17-29-33-13-5-12-28-26(23)33/h5-9,12-13,16-18,20-21H,10-11,14-15H2,1-4H3,(H,30,35)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188944
PNG
(US9169260, 210)
Show SMILES CCCC(C)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C27H33N7O/c1-4-6-20(3)32-15-11-21(12-16-32)24-17-25(34(31-24)22-9-7-19(2)8-10-22)30-27(35)23-18-29-33-14-5-13-28-26(23)33/h5,7-10,13-14,17-18,20-21H,4,6,11-12,15-16H2,1-3H3,(H,30,35)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188948
PNG
(US9169260, 214)
Show SMILES CC(N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1)C(=O)N1CCCC1
Show InChI InChI=1S/C29H34N8O2/c1-20-6-8-23(9-7-20)37-26(32-28(38)24-19-31-36-15-5-12-30-27(24)36)18-25(33-37)22-10-16-34(17-11-22)21(2)29(39)35-13-3-4-14-35/h5-9,12,15,18-19,21-22H,3-4,10-11,13-14,16-17H2,1-2H3,(H,32,38)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188953
PNG
(US9169260, 219)
Show SMILES CC(C)CN1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C26H31N7O/c1-18(2)17-31-13-9-20(10-14-31)23-15-24(33(30-23)21-7-5-19(3)6-8-21)29-26(34)22-16-28-32-12-4-11-27-25(22)32/h4-8,11-12,15-16,18,20H,9-10,13-14,17H2,1-3H3,(H,29,34)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188965
PNG
(US9169260, 231)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(Cc2cscn2)CC1
Show InChI InChI=1S/C26H26N8OS/c1-18-3-5-21(6-4-18)34-24(30-26(35)22-14-29-33-10-2-9-27-25(22)33)13-23(31-34)19-7-11-32(12-8-19)15-20-16-36-17-28-20/h2-6,9-10,13-14,16-17,19H,7-8,11-12,15H2,1H3,(H,30,35)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188966
PNG
(US9169260, 232)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(Cc2ncco2)CC1
Show InChI InChI=1S/C26H26N8O2/c1-18-3-5-20(6-4-18)34-23(30-26(35)21-16-29-33-11-2-9-28-25(21)33)15-22(31-34)19-7-12-32(13-8-19)17-24-27-10-14-36-24/h2-6,9-11,14-16,19H,7-8,12-13,17H2,1H3,(H,30,35)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188969
PNG
(US9169260, 235)
Show SMILES CC(C)NC(=O)N1CC(C1)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C29H35N9O2/c1-19(2)32-29(40)36-17-23(18-36)35-13-9-21(10-14-35)25-15-26(38(34-25)22-7-5-20(3)6-8-22)33-28(39)24-16-31-37-12-4-11-30-27(24)37/h4-8,11-12,15-16,19,21,23H,9-10,13-14,17-18H2,1-3H3,(H,32,40)(H,33,39)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188977
PNG
(US9169260, 243)
Show SMILES CCS(=O)(=O)N1CC(C1)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C27H32N8O3S/c1-3-39(37,38)33-17-22(18-33)32-13-9-20(10-14-32)24-15-25(35(31-24)21-7-5-19(2)6-8-21)30-27(36)23-16-29-34-12-4-11-28-26(23)34/h4-8,11-12,15-16,20,22H,3,9-10,13-14,17-18H2,1-2H3,(H,30,36)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188988
PNG
(US9169260, 254)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)C1CCC2CC12
Show InChI InChI=1S/C28H31N7O/c1-18-3-6-21(7-4-18)35-26(31-28(36)23-17-30-34-12-2-11-29-27(23)34)16-24(32-35)19-9-13-33(14-10-19)25-8-5-20-15-22(20)25/h2-4,6-7,11-12,16-17,19-20,22,25H,5,8-10,13-15H2,1H3,(H,31,36)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188994
PNG
(US9169260, 260)
Show SMILES CC(CC(F)(F)F)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C26H28F3N7O/c1-17-4-6-20(7-5-17)36-23(32-25(37)21-16-31-35-11-3-10-30-24(21)35)14-22(33-36)19-8-12-34(13-9-19)18(2)15-26(27,28)29/h3-7,10-11,14,16,18-19H,8-9,12-13,15H2,1-2H3,(H,32,37)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188996
PNG
(US9169260, 262)
Show SMILES CN(C1CCC(CC1)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cn1)S(C)(=O)=O |(-8.54,-6.79,;-7.05,-7.19,;-5.96,-6.1,;-6.36,-4.61,;-5.27,-3.53,;-3.78,-3.92,;-3.39,-5.41,;-4.47,-6.5,;-2.69,-2.84,;-3.09,-1.35,;-2,-.26,;-.52,-.66,;-.12,-2.14,;-1.21,-3.23,;.57,.43,;.1,1.9,;1.34,2.8,;1.34,4.34,;.01,5.11,;-1.33,4.34,;.01,6.65,;1.25,7.56,;.78,9.02,;-.76,9.02,;-1.79,10.17,;-3.3,9.85,;-3.77,8.38,;-2.74,7.24,;-1.24,7.56,;2.59,1.9,;2.11,.43,;4.08,2.3,;5.16,1.21,;6.65,1.6,;7.05,3.09,;8.54,3.49,;5.96,4.18,;4.47,3.78,;-6.65,-8.68,;-5.16,-8.28,;-6.25,-10.17,;-8.14,-9.08,)|
Show InChI InChI=1S/C29H37N9O3S/c1-20-5-10-26(31-18-20)38-27(33-29(39)24-19-32-37-14-4-13-30-28(24)37)17-25(34-38)21-11-15-36(16-12-21)23-8-6-22(7-9-23)35(2)42(3,40)41/h4-5,10,13-14,17-19,21-23H,6-9,11-12,15-16H2,1-3H3,(H,33,39)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189021
PNG
(US9169260, 287)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCCN(Cc2ccn[nH]2)C1
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189026
PNG
(US9169260, 292)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCCN(Cc2ccc(F)cn2)C1
Show InChI InChI=1S/C28H27FN8O/c1-19-5-9-23(10-6-19)37-26(33-28(38)24-16-32-36-13-3-11-30-27(24)36)14-25(34-37)20-4-2-12-35(17-20)18-22-8-7-21(29)15-31-22/h3,5-11,13-16,20H,2,4,12,17-18H2,1H3,(H,33,38)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189036
PNG
(US9169260, 302)
Show SMILES COc1ccc(CN2CCCC(C2)c2cc(NC(=O)c3cnn4cccnc34)n(n2)-c2ccc(C)cc2)cn1
Show InChI InChI=1S/C29H30N8O2/c1-20-6-9-23(10-7-20)37-26(33-29(38)24-17-32-36-14-4-12-30-28(24)36)15-25(34-37)22-5-3-13-35(19-22)18-21-8-11-27(39-2)31-16-21/h4,6-12,14-17,22H,3,5,13,18-19H2,1-2H3,(H,33,38)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189044
PNG
(US9169260, 310)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CN(Cc2cncnc2)C1
Show InChI InChI=1S/C25H23N9O/c1-17-3-5-20(6-4-17)34-23(30-25(35)21-12-29-33-8-2-7-28-24(21)33)9-22(31-34)19-14-32(15-19)13-18-10-26-16-27-11-18/h2-12,16,19H,13-15H2,1H3,(H,30,35)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189046
PNG
(US9169260, 312)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CN(Cc2cncs2)C1
Show InChI InChI=1S/C24H22N8OS/c1-16-3-5-18(6-4-16)32-22(28-24(33)20-11-27-31-8-2-7-26-23(20)31)9-21(29-32)17-12-30(13-17)14-19-10-25-15-34-19/h2-11,15,17H,12-14H2,1H3,(H,28,33)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189059
PNG
(US9169260, 328)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)-c1ccnc(CN2CCCCC2)c1
Show InChI InChI=1S/C28H28N8O/c1-20-6-8-23(9-7-20)36-26(32-28(37)24-18-31-35-15-5-11-30-27(24)35)17-25(33-36)21-10-12-29-22(16-21)19-34-13-3-2-4-14-34/h5-12,15-18H,2-4,13-14,19H2,1H3,(H,32,37)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189061
PNG
(US9169260, 330)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)-c1ccc(CO)nc1
Show InChI InChI=1S/C23H19N7O2/c1-15-3-7-18(8-4-15)30-21(11-20(28-30)16-5-6-17(14-31)25-12-16)27-23(32)19-13-26-29-10-2-9-24-22(19)29/h2-13,31H,14H2,1H3,(H,27,32)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189063
PNG
(US9169260, 332)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)-c1cncc(CO)c1
Show InChI InChI=1S/C23H19N7O2/c1-15-3-5-18(6-4-15)30-21(10-20(28-30)17-9-16(14-31)11-24-12-17)27-23(32)19-13-26-29-8-2-7-25-22(19)29/h2-13,31H,14H2,1H3,(H,27,32)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189067
PNG
(US9169260, 336)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)-c1ccc(cc1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C26H22N6O3S/c1-17-3-7-19(8-4-17)32-24(29-26(33)22-16-28-31-14-2-13-27-25(22)31)15-23(30-32)18-5-9-20(10-6-18)36(34,35)21-11-12-21/h2-10,13-16,21H,11-12H2,1H3,(H,29,33)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189071
PNG
(US9169260, 340)
Show SMILES CCN(CC)S(=O)(=O)c1ccc(-c2cc(NC(=O)c3cnn4cccnc34)n(n2)-c2ccc(C)cc2)c(C)c1
Show InChI InChI=1S/C28H29N7O3S/c1-5-33(6-2)39(37,38)22-12-13-23(20(4)16-22)25-17-26(35(32-25)21-10-8-19(3)9-11-21)31-28(36)24-18-30-34-15-7-14-29-27(24)34/h7-18H,5-6H2,1-4H3,(H,31,36)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189074
PNG
(US9169260, 343)
Show SMILES CCN(CC)S(=O)(=O)c1ccc(cc1)-c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C27H27N7O3S/c1-4-32(5-2)38(36,37)22-13-9-20(10-14-22)24-17-25(34(31-24)21-11-7-19(3)8-12-21)30-27(35)23-18-29-33-16-6-15-28-26(23)33/h6-18H,4-5H2,1-3H3,(H,30,35)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189080
PNG
(US9169260, 349)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C26H23N7O2/c1-17-5-11-20(12-6-17)33-23(29-25(34)21-16-28-32-14-4-13-27-24(21)32)15-22(30-33)18-7-9-19(10-8-18)26(35)31(2)3/h4-16H,1-3H3,(H,29,34)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189083
PNG
(US9169260, 352)
Show SMILES CCS(=O)(=O)c1ccc(cc1)-c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C25H22N6O3S/c1-3-35(33,34)20-11-7-18(8-12-20)22-15-23(31(29-22)19-9-5-17(2)6-10-19)28-25(32)21-16-27-30-14-4-13-26-24(21)30/h4-16H,3H2,1-2H3,(H,28,32)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189084
PNG
(US9169260, 353)
Show SMILES CN(C)S(=O)(=O)c1ccc(cc1)-c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C25H23N7O3S/c1-17-5-9-19(10-6-17)32-23(28-25(33)21-16-27-31-14-4-13-26-24(21)31)15-22(29-32)18-7-11-20(12-8-18)36(34,35)30(2)3/h4-16H,1-3H3,(H,28,33)
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n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189104
PNG
(US9169260, 373)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)S(=O)C1CCCCC1
Show InChI InChI=1S/C28H33N7O2S/c1-20-8-10-22(11-9-20)35-26(31-28(36)24-19-30-34-15-5-14-29-27(24)34)18-25(32-35)21-12-16-33(17-13-21)38(37)23-6-3-2-4-7-23/h5,8-11,14-15,18-19,21,23H,2-4,6-7,12-13,16-17H2,1H3,(H,31,36)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189110
PNG
(US9169260, 379)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)S(=O)c1cccc(F)c1
Show InChI InChI=1S/C28H26FN7O2S/c1-19-6-8-22(9-7-19)36-26(32-28(37)24-18-31-35-13-3-12-30-27(24)35)17-25(33-36)20-10-14-34(15-11-20)39(38)23-5-2-4-21(29)16-23/h2-9,12-13,16-18,20H,10-11,14-15H2,1H3,(H,32,37)
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n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 399 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%