BindingDB logo
myBDB logout

Patent code US9169260

Compile Data Set for Download or QSAR

Found 399 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188768
PNG
(US9169260, 34)
Show SMILES Cc1ccc(cc1)-c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(F)cc1F
Show InChI InChI=1S/C23H16F2N6O/c1-14-3-5-15(6-4-14)19-12-21(31(29-19)20-8-7-16(24)11-18(20)25)28-23(32)17-13-27-30-10-2-9-26-22(17)30/h2-13H,1H3,(H,28,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188779
PNG
(US9169260, 45)
Show SMILES Cc1ccc(cc1)-n1nc(CC2CCOCC2)cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C23H24N6O2/c1-16-3-5-19(6-4-16)29-21(14-18(27-29)13-17-7-11-31-12-8-17)26-23(30)20-15-25-28-10-2-9-24-22(20)28/h2-6,9-10,14-15,17H,7-8,11-13H2,1H3,(H,26,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188782
PNG
(US9169260, 48)
Show SMILES CN1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(F)cc1F
Show InChI InChI=1S/C22H21F2N7O/c1-29-9-5-14(6-10-29)18-12-20(31(28-18)19-4-3-15(23)11-17(19)24)27-22(32)16-13-26-30-8-2-7-25-21(16)30/h2-4,7-8,11-14H,5-6,9-10H2,1H3,(H,27,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188788
PNG
(US9169260, 54)
Show SMILES O=C(Nc1cc(nn1-c1ccc(cc1)C1CC1)C1CCN(CC1)S(=O)(=O)C1CC1)c1cnn2cccnc12
Show InChI InChI=1S/C27H29N7O3S/c35-27(23-17-29-33-13-1-12-28-26(23)33)30-25-16-24(20-10-14-32(15-11-20)38(36,37)22-8-9-22)31-34(25)21-6-4-19(5-7-21)18-2-3-18/h1,4-7,12-13,16-18,20,22H,2-3,8-11,14-15H2,(H,30,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188793
PNG
(US9169260, 59)
Show SMILES Cc1ccc(c(F)c1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)C1CCC1
Show InChI InChI=1S/C26H28FN7O/c1-17-6-7-23(21(27)14-17)34-24(30-26(35)20-16-29-33-11-3-10-28-25(20)33)15-22(31-34)18-8-12-32(13-9-18)19-4-2-5-19/h3,6-7,10-11,14-16,18-19H,2,4-5,8-9,12-13H2,1H3,(H,30,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188795
PNG
(US9169260, 61)
Show SMILES COc1ccc(c(F)c1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCNCC1
Show InChI InChI=1S/C22H22FN7O2/c1-32-15-3-4-19(17(23)11-15)30-20(12-18(28-30)14-5-8-24-9-6-14)27-22(31)16-13-26-29-10-2-7-25-21(16)29/h2-4,7,10-14,24H,5-6,8-9H2,1H3,(H,27,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188806
PNG
(US9169260, 72)
Show SMILES Fc1cc(ccc1-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCNCC1)C1CC1
Show InChI InChI=1S/C24H24FN7O/c25-19-12-17(15-2-3-15)4-5-21(19)32-22(13-20(30-32)16-6-9-26-10-7-16)29-24(33)18-14-28-31-11-1-8-27-23(18)31/h1,4-5,8,11-16,26H,2-3,6-7,9-10H2,(H,29,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188808
PNG
(US9169260, 74)
Show SMILES CC(C)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(cc1F)C1CC1
Show InChI InChI=1S/C27H30FN7O/c1-17(2)33-12-8-19(9-13-33)23-15-25(31-27(36)21-16-30-34-11-3-10-29-26(21)34)35(32-23)24-7-6-20(14-22(24)28)18-4-5-18/h3,6-7,10-11,14-19H,4-5,8-9,12-13H2,1-2H3,(H,31,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem

Similars
PDB
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188814
PNG
(US9169260, 80)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCNC1
Show InChI InChI=1S/C21H21N7O/c1-14-3-5-16(6-4-14)28-19(11-18(26-28)15-7-9-22-12-15)25-21(29)17-13-24-27-10-2-8-23-20(17)27/h2-6,8,10-11,13,15,22H,7,9,12H2,1H3,(H,25,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188819
PNG
(US9169260, 85)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CN(C1)S(=O)(=O)C1CCCC1
Show InChI InChI=1S/C25H27N7O3S/c1-17-7-9-19(10-8-17)32-23(28-25(33)21-14-27-31-12-4-11-26-24(21)31)13-22(29-32)18-15-30(16-18)36(34,35)20-5-2-3-6-20/h4,7-14,18,20H,2-3,5-6,15-16H2,1H3,(H,28,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188835
PNG
(US9169260, 101)
Show SMILES Cc1ccc(cc1)-c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(cc1F)C1CC1
Show InChI InChI=1S/C26H21FN6O/c1-16-3-5-18(6-4-16)22-14-24(30-26(34)20-15-29-32-12-2-11-28-25(20)32)33(31-22)23-10-9-19(13-21(23)27)17-7-8-17/h2-6,9-15,17H,7-8H2,1H3,(H,30,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188839
PNG
(US9169260, 105)
Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cc(NC=O)cnc12)C1CCNCC1
Show InChI InChI=1S/C23H24N8O3/c1-34-18-4-2-17(3-5-18)31-21(10-20(29-31)15-6-8-24-9-7-15)28-23(33)19-12-27-30-13-16(26-14-32)11-25-22(19)30/h2-5,10-15,24H,6-9H2,1H3,(H,26,32)(H,28,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
KEGG
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188852
PNG
(US9169260, 118)
Show SMILES COC(=O)N1CCC(CC1)c1cc(NC(=O)c2cnn3cc(Br)cnc23)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C24H24BrN7O3/c1-15-3-5-18(6-4-15)32-21(11-20(29-32)16-7-9-30(10-8-16)24(34)35-2)28-23(33)19-13-27-31-14-17(25)12-26-22(19)31/h3-6,11-14,16H,7-10H2,1-2H3,(H,28,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188865
PNG
(US9169260, 131)
Show SMILES COc1ccc(cc1)-c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C24H20N6O2/c1-16-4-8-18(9-5-16)30-22(14-21(28-30)17-6-10-19(32-2)11-7-17)27-24(31)20-15-26-29-13-3-12-25-23(20)29/h3-15H,1-2H3,(H,27,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188869
PNG
(US9169260, 135)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)-c1ccc(F)cc1
Show InChI InChI=1S/C23H17FN6O/c1-15-3-9-18(10-4-15)30-21(13-20(28-30)16-5-7-17(24)8-6-16)27-23(31)19-14-26-29-12-2-11-25-22(19)29/h2-14H,1H3,(H,27,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a>1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188871
PNG
(US9169260, 137)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)-c1cncnc1
Show InChI InChI=1S/C21H16N8O/c1-14-3-5-16(6-4-14)29-19(9-18(27-29)15-10-22-13-23-11-15)26-21(30)17-12-25-28-8-2-7-24-20(17)28/h2-13H,1H3,(H,26,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a>1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188872
PNG
(US9169260, 138)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1=CCNCC1 |t:28|
Show InChI InChI=1S/C22H21N7O/c1-15-3-5-17(6-4-15)29-20(13-19(27-29)16-7-10-23-11-8-16)26-22(30)18-14-25-28-12-2-9-24-21(18)28/h2-7,9,12-14,23H,8,10-11H2,1H3,(H,26,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188873
PNG
(US9169260, 139)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)C1=C2N=CC=C[N]2=NC1)C1=CCN(CC1)S(C)(=O)=O |c:17,19,21,24,t:28|
Show InChI InChI=1S/C23H24N7O3S/c1-16-4-6-18(7-5-16)30-21(26-23(31)19-15-25-29-11-3-10-24-22(19)29)14-20(27-30)17-8-12-28(13-9-17)34(2,32)33/h3-8,10-11,14H,9,12-13,15H2,1-2H3,(H,26,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188881
PNG
(US9169260, 147)
Show SMILES CN1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(cn1)C1CC1
Show InChI InChI=1S/C24H26N8O/c1-30-11-7-17(8-12-30)20-13-22(28-24(33)19-15-27-31-10-2-9-25-23(19)31)32(29-20)21-6-5-18(14-26-21)16-3-4-16/h2,5-6,9-10,13-17H,3-4,7-8,11-12H2,1H3,(H,28,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188886
PNG
(US9169260, 152)
Show SMILES Cc1ccc(nc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCNCC1
Show InChI InChI=1S/C21H22N8O/c1-14-3-4-18(24-12-14)29-19(11-17(27-29)15-5-8-22-9-6-15)26-21(30)16-13-25-28-10-2-7-23-20(16)28/h2-4,7,10-13,15,22H,5-6,8-9H2,1H3,(H,26,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188890
PNG
(US9169260, 156)
Show SMILES COc1ccc(nc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C22H24N8O4S/c1-34-16-4-5-19(24-13-16)30-20(26-22(31)17-14-25-29-9-3-8-23-21(17)29)12-18(27-30)15-6-10-28(11-7-15)35(2,32)33/h3-5,8-9,12-15H,6-7,10-11H2,1-2H3,(H,26,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188891
PNG
(US9169260, 157)
Show SMILES CS(=O)(=O)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(CN)cn1
Show InChI InChI=1S/C22H25N9O3S/c1-35(33,34)29-9-5-16(6-10-29)18-11-20(31(28-18)19-4-3-15(12-23)13-25-19)27-22(32)17-14-26-30-8-2-7-24-21(17)30/h2-4,7-8,11,13-14,16H,5-6,9-10,12,23H2,1H3,(H,27,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188899
PNG
(US9169260, 165)
Show SMILES CS(=O)(=O)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C=O)cn1
Show InChI InChI=1S/C22H22N8O4S/c1-35(33,34)28-9-5-16(6-10-28)18-11-20(30(27-18)19-4-3-15(14-31)12-24-19)26-22(32)17-13-25-29-8-2-7-23-21(17)29/h2-4,7-8,11-14,16H,5-6,9-10H2,1H3,(H,26,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188912
PNG
(US9169260, 178)
Show SMILES CN1CCN(CC1)S(=O)(=O)c1ccc(cc1)-c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cn1
Show InChI InChI=1S/C27H27N9O3S/c1-19-4-9-24(29-17-19)36-25(31-27(37)22-18-30-35-11-3-10-28-26(22)35)16-23(32-36)20-5-7-21(8-6-20)40(38,39)34-14-12-33(2)13-15-34/h3-11,16-18H,12-15H2,1-2H3,(H,31,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188914
PNG
(US9169260, 180)
Show SMILES Cc1ccc(nc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CC1
Show InChI InChI=1S/C19H17N7O/c1-12-3-6-16(21-10-12)26-17(9-15(24-26)13-4-5-13)23-19(27)14-11-22-25-8-2-7-20-18(14)25/h2-3,6-11,13H,4-5H2,1H3,(H,23,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a>1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188935
PNG
(US9169260, 201)
Show SMILES CN1CCN(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(cn1)C1CC1
Show InChI InChI=1S/C23H25N9O/c1-29-9-11-30(12-10-29)21-13-20(27-23(33)18-15-26-31-8-2-7-24-22(18)31)32(28-21)19-6-5-17(14-25-19)16-3-4-16/h2,5-8,13-16H,3-4,9-12H2,1H3,(H,27,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188939
PNG
(US9169260, 205)
Show SMILES CN1CCC(CC1)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C28H34N8O/c1-20-4-6-23(7-5-20)36-26(31-28(37)24-19-30-35-13-3-12-29-27(24)35)18-25(32-36)21-8-16-34(17-9-21)22-10-14-33(2)15-11-22/h3-7,12-13,18-19,21-22H,8-11,14-17H2,1-2H3,(H,31,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a>1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188959
PNG
(US9169260, 225)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(Cc2cccnc2)CC1
Show InChI InChI=1S/C28H28N8O/c1-20-5-7-23(8-6-20)36-26(32-28(37)24-18-31-35-13-3-12-30-27(24)35)16-25(33-36)22-9-14-34(15-10-22)19-21-4-2-11-29-17-21/h2-8,11-13,16-18,22H,9-10,14-15,19H2,1H3,(H,32,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188960
PNG
(US9169260, 226)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(Cc2ccccn2)CC1
Show InChI InChI=1S/C28H28N8O/c1-20-6-8-23(9-7-20)36-26(32-28(37)24-18-31-35-14-4-13-30-27(24)35)17-25(33-36)21-10-15-34(16-11-21)19-22-5-2-3-12-29-22/h2-9,12-14,17-18,21H,10-11,15-16,19H2,1H3,(H,32,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188970
PNG
(US9169260, 236)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)C1CN(C1)C(=O)NC(C)(C)C
Show InChI InChI=1S/C30H37N9O2/c1-20-6-8-22(9-7-20)39-26(33-28(40)24-17-32-38-13-5-12-31-27(24)38)16-25(35-39)21-10-14-36(15-11-21)23-18-37(19-23)29(41)34-30(2,3)4/h5-9,12-13,16-17,21,23H,10-11,14-15,18-19H2,1-4H3,(H,33,40)(H,34,41)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188971
PNG
(US9169260, 237)
Show SMILES CCNC(=O)N1CC(C1)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C28H33N9O2/c1-3-29-28(39)35-17-22(18-35)34-13-9-20(10-14-34)24-15-25(37(33-24)21-7-5-19(2)6-8-21)32-27(38)23-16-31-36-12-4-11-30-26(23)36/h4-8,11-12,15-16,20,22H,3,9-10,13-14,17-18H2,1-2H3,(H,29,39)(H,32,38)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188972
PNG
(US9169260, 238)
Show SMILES COC(=O)N1CC(C1)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C27H30N8O3/c1-18-4-6-20(7-5-18)35-24(30-26(36)22-15-29-34-11-3-10-28-25(22)34)14-23(31-35)19-8-12-32(13-9-19)21-16-33(17-21)27(37)38-2/h3-7,10-11,14-15,19,21H,8-9,12-13,16-17H2,1-2H3,(H,30,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188988
PNG
(US9169260, 254)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)C1CCC2CC12
Show InChI InChI=1S/C28H31N7O/c1-18-3-6-21(7-4-18)35-26(31-28(36)23-17-30-34-12-2-11-29-27(23)34)16-24(32-35)19-9-13-33(14-10-19)25-8-5-20-15-22(20)25/h2-4,6-7,11-12,16-17,19-20,22,25H,5,8-10,13-15H2,1H3,(H,31,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188992
PNG
(US9169260, 258)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)C1CC(C1)C#N |(8.22,1.68,;6.73,1.29,;6.33,-.2,;4.85,-.6,;3.76,.49,;4.16,1.98,;5.64,2.37,;2.27,.09,;1.79,-1.37,;.25,-1.37,;-.22,.09,;1.02,1,;1.02,2.54,;-.31,3.31,;-1.64,2.54,;-.31,4.85,;.94,5.75,;.46,7.22,;-1.08,7.22,;-2.11,8.36,;-3.62,8.04,;-4.09,6.57,;-3.06,5.43,;-1.56,5.75,;-.84,-2.46,;-2.32,-2.07,;-3.41,-3.15,;-3.01,-4.64,;-1.53,-5.04,;-.44,-3.95,;-4.1,-5.73,;-5.64,-5.73,;-5.64,-7.27,;-4.1,-7.27,;-6.73,-8.36,;-8.22,-7.96,)|
Show InChI InChI=1S/C27H28N8O/c1-18-3-5-21(6-4-18)35-25(31-27(36)23-17-30-34-10-2-9-29-26(23)34)15-24(32-35)20-7-11-33(12-8-20)22-13-19(14-22)16-28/h2-6,9-10,15,17,19-20,22H,7-8,11-14H2,1H3,(H,31,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188996
PNG
(US9169260, 262)
Show SMILES CN(C1CCC(CC1)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cn1)S(C)(=O)=O |(-8.54,-6.79,;-7.05,-7.19,;-5.96,-6.1,;-6.36,-4.61,;-5.27,-3.53,;-3.78,-3.92,;-3.39,-5.41,;-4.47,-6.5,;-2.69,-2.84,;-3.09,-1.35,;-2,-.26,;-.52,-.66,;-.12,-2.14,;-1.21,-3.23,;.57,.43,;.1,1.9,;1.34,2.8,;1.34,4.34,;.01,5.11,;-1.33,4.34,;.01,6.65,;1.25,7.56,;.78,9.02,;-.76,9.02,;-1.79,10.17,;-3.3,9.85,;-3.77,8.38,;-2.74,7.24,;-1.24,7.56,;2.59,1.9,;2.11,.43,;4.08,2.3,;5.16,1.21,;6.65,1.6,;7.05,3.09,;8.54,3.49,;5.96,4.18,;4.47,3.78,;-6.65,-8.68,;-5.16,-8.28,;-6.25,-10.17,;-8.14,-9.08,)|
Show InChI InChI=1S/C29H37N9O3S/c1-20-5-10-26(31-18-20)38-27(33-29(39)24-19-32-37-14-4-13-30-28(24)37)17-25(34-38)21-11-15-36(16-12-21)23-8-6-22(7-9-23)35(2)42(3,40)41/h4-5,10,13-14,17-19,21-23H,6-9,11-12,15-16H2,1-3H3,(H,33,39)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189002
PNG
(US9169260, 268)
Show SMILES Cc1ccc(nc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)C1CCc2ccncc2C1
Show InChI InChI=1S/C30H31N9O/c1-20-3-6-27(33-17-20)39-28(35-30(40)25-19-34-38-12-2-10-32-29(25)38)16-26(36-39)22-8-13-37(14-9-22)24-5-4-21-7-11-31-18-23(21)15-24/h2-3,6-7,10-12,16-19,22,24H,4-5,8-9,13-15H2,1H3,(H,35,40)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189006
PNG
(US9169260, 272)
Show SMILES CC1CCC(C1)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cn1
Show InChI InChI=1S/C27H32N8O/c1-18-4-6-21(14-18)33-12-8-20(9-13-33)23-15-25(35(32-23)24-7-5-19(2)16-29-24)31-27(36)22-17-30-34-11-3-10-28-26(22)34/h3,5,7,10-11,15-18,20-21H,4,6,8-9,12-14H2,1-2H3,(H,31,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189007
PNG
(US9169260, 273)
Show SMILES C[C@@H]1CCC(C1)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cn1 |r|
Show InChI InChI=1S/C27H32N8O/c1-18-4-6-21(14-18)33-12-8-20(9-13-33)23-15-25(35(32-23)24-7-5-19(2)16-29-24)31-27(36)22-17-30-34-11-3-10-28-26(22)34/h3,5,7,10-11,15-18,20-21H,4,6,8-9,12-14H2,1-2H3,(H,31,36)/t18-,21?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189008
PNG
(US9169260, 274)
Show SMILES Cc1ccc(nc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)C1CCC1
Show InChI InChI=1S/C25H28N8O/c1-17-6-7-22(27-15-17)33-23(29-25(34)20-16-28-32-11-3-10-26-24(20)32)14-21(30-33)18-8-12-31(13-9-18)19-4-2-5-19/h3,6-7,10-11,14-16,18-19H,2,4-5,8-9,12-13H2,1H3,(H,29,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189013
PNG
(US9169260, 279)
Show SMILES CCN1CCC(CC1)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cn1
Show InChI InChI=1S/C28H35N9O/c1-3-34-13-9-22(10-14-34)35-15-7-21(8-16-35)24-17-26(37(33-24)25-6-5-20(2)18-30-25)32-28(38)23-19-31-36-12-4-11-29-27(23)36/h4-6,11-12,17-19,21-22H,3,7-10,13-16H2,1-2H3,(H,32,38)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189018
PNG
(US9169260, 284)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCCN(Cc2cncs2)C1
Show InChI InChI=1S/C26H26N8OS/c1-18-5-7-20(8-6-18)34-24(30-26(35)22-14-29-33-11-3-9-28-25(22)33)12-23(31-34)19-4-2-10-32(15-19)16-21-13-27-17-36-21/h3,5-9,11-14,17,19H,2,4,10,15-16H2,1H3,(H,30,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189048
PNG
(US9169260, 314)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CN(Cc2cccnc2)C1
Show InChI InChI=1S/C26H24N8O/c1-18-5-7-21(8-6-18)34-24(30-26(35)22-14-29-33-11-3-10-28-25(22)33)12-23(31-34)20-16-32(17-20)15-19-4-2-9-27-13-19/h2-14,20H,15-17H2,1H3,(H,30,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189057
PNG
(US9169260, 326)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)-c1cnn(C)c1
Show InChI InChI=1S/C21H18N8O/c1-14-4-6-16(7-5-14)29-19(10-18(26-29)15-11-23-27(2)13-15)25-21(30)17-12-24-28-9-3-8-22-20(17)28/h3-13H,1-2H3,(H,25,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189066
PNG
(US9169260, 335)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)-c1csc(n1)N1CCOCC1
Show InChI InChI=1S/C24H22N8O2S/c1-16-3-5-17(6-4-16)32-21(28-23(33)18-14-26-31-8-2-7-25-22(18)31)13-19(29-32)20-15-35-24(27-20)30-9-11-34-12-10-30/h2-8,13-15H,9-12H2,1H3,(H,28,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189069
PNG
(US9169260, 338)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)-c1ccc(cc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C25H19F3N6O3S/c1-15-4-6-16(7-5-15)34-22(31-24(35)19-14-30-33-11-3-10-29-23(19)33)13-21(32-34)18-9-8-17(38(2,36)37)12-20(18)25(26,27)28/h3-14H,1-2H3,(H,31,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189071
PNG
(US9169260, 340)
Show SMILES CCN(CC)S(=O)(=O)c1ccc(-c2cc(NC(=O)c3cnn4cccnc34)n(n2)-c2ccc(C)cc2)c(C)c1
Show InChI InChI=1S/C28H29N7O3S/c1-5-33(6-2)39(37,38)22-12-13-23(20(4)16-22)25-17-26(35(32-25)21-10-8-19(3)9-11-21)31-28(36)24-18-30-34-15-7-14-29-27(24)34/h7-18H,5-6H2,1-4H3,(H,31,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189072
PNG
(US9169260, 341)
Show SMILES CC(C)S(=O)(=O)c1ccc(cc1)-c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C26H24N6O3S/c1-17(2)36(34,35)21-11-7-19(8-12-21)23-15-24(32(30-23)20-9-5-18(3)6-10-20)29-26(33)22-16-28-31-14-4-13-27-25(22)31/h4-17H,1-3H3,(H,29,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189079
PNG
(US9169260, 348)
Show SMILES CNC(=O)c1ccc(cc1)-c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C25H21N7O2/c1-16-4-10-19(11-5-16)32-22(29-25(34)20-15-28-31-13-3-12-27-23(20)31)14-21(30-32)17-6-8-18(9-7-17)24(33)26-2/h3-15H,1-2H3,(H,26,33)(H,29,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189084
PNG
(US9169260, 353)
Show SMILES CN(C)S(=O)(=O)c1ccc(cc1)-c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C25H23N7O3S/c1-17-5-9-19(10-6-17)32-23(28-25(33)21-16-27-31-14-4-13-26-24(21)31)15-22(29-32)18-7-11-20(12-8-18)36(34,35)30(2)3/h4-16H,1-3H3,(H,28,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM189085
PNG
(US9169260, 354)
Show SMILES CN1CCC(=CC1=O)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1 |c:4|
Show InChI InChI=1S/C23H21N7O2/c1-15-4-6-17(7-5-15)30-20(13-19(27-30)16-8-11-28(2)21(31)12-16)26-23(32)18-14-25-29-10-3-9-24-22(18)29/h3-7,9-10,12-14H,8,11H2,1-2H3,(H,26,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a<1.00E+3n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 399 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%