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Patent code US9669031

Compile Data Set for Download or QSAR

Found 313 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM164268
PNG
(US9669031, 7 3-methyl-6-(pyrimidin-4-ylamino)-3-(2...)
Show SMILES CC1(CC(F)(F)F)NC(=O)c2ccc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C14H12F3N5O2/c1-13(6-14(15,16)17)21-11(23)9-3-2-8(12(24)22(9)13)20-10-4-5-18-7-19-10/h2-5,7H,6H2,1H3,(H,21,23)(H,18,19,20)
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n/an/a<10n/an/an/an/an/a25



eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM164274
PNG
(US9669031, 12 3-(3-fluorophenyl)-3-methyl-6-(pyrim...)
Show SMILES CC1(NC(=O)c2ccc(Nc3ccncn3)c(=O)n12)c1cccc(F)c1
Show InChI InChI=1S/C18H14FN5O2/c1-18(11-3-2-4-12(19)9-11)23-16(25)14-6-5-13(17(26)24(14)18)22-15-7-8-20-10-21-15/h2-10H,1H3,(H,23,25)(H,20,21,22)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM164280
PNG
(US9669031, 16 3-methyl-6-(pyrimidin-4-ylamino)-3-(...)
Show SMILES CC1(NC(=O)c2ccc(Nc3ccncn3)c(=O)n12)c1ccsc1
Show InChI InChI=1S/C16H13N5O2S/c1-16(10-5-7-24-8-10)20-14(22)12-3-2-11(15(23)21(12)16)19-13-4-6-17-9-18-13/h2-9H,1H3,(H,20,22)(H,17,18,19)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM164590
PNG
(US9669031, 18 3-(3-chlorophenyl)-3-methyl-6-(pyrim...)
Show SMILES CC1(NC(=O)c2ccc(Nc3ccncn3)c(=O)n12)c1cccc(Cl)c1
Show InChI InChI=1S/C18H14ClN5O2/c1-18(11-3-2-4-12(19)9-11)23-16(25)14-6-5-13(17(26)24(14)18)22-15-7-8-20-10-21-15/h2-10H,1H3,(H,23,25)(H,20,21,22)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM164599
PNG
(US9669031, 20 6-(pyrimidin-4-ylamino)-1H-spiro[imi...)
Show SMILES CC(C)(C)OC(=O)N1CCCC2(C1)NC(=O)c1ccc(Nc3ccncn3)c(=O)n21
Show InChI InChI=1S/C20H24N6O4/c1-19(2,3)30-18(29)25-10-4-8-20(11-25)24-16(27)14-6-5-13(17(28)26(14)20)23-15-7-9-21-12-22-15/h5-7,9,12H,4,8,10-11H2,1-3H3,(H,24,27)(H,21,22,23)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM164600
PNG
(US9669031, 21 N-[6-[(1,5-dioxospiro[2H-imidazo[1,5...)
Show SMILES O=C(Nc1cc(Nc2ccc3C(=O)NC4(CCCC4)n3c2=O)ncn1)C1CC1
Show InChI InChI=1S/C19H20N6O3/c26-16(11-3-4-11)23-15-9-14(20-10-21-15)22-12-5-6-13-17(27)24-19(7-1-2-8-19)25(13)18(12)28/h5-6,9-11H,1-4,7-8H2,(H,24,27)(H2,20,21,22,23,26)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168140
PNG
(US9669031, 30 N-[6-[[3-(3-fluorophenyl)-3-methyl-1...)
Show SMILES CC1(NC(=O)c2ccc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)c1cccc(F)c1
Show InChI InChI=1S/C22H19FN6O3/c1-22(13-3-2-4-14(23)9-13)28-20(31)16-8-7-15(21(32)29(16)22)26-17-10-18(25-11-24-17)27-19(30)12-5-6-12/h2-4,7-12H,5-6H2,1H3,(H,28,31)(H2,24,25,26,27,30)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168203
PNG
(US9669031, 34 3-methyl-3-(pyridin-2-yl)-6-(pyrimid...)
Show SMILES CC1(NC(=O)c2ccc(Nc3ccncn3)c(=O)n12)c1ccccn1
Show InChI InChI=1S/C17H14N6O2/c1-17(13-4-2-3-8-19-13)22-15(24)12-6-5-11(16(25)23(12)17)21-14-7-9-18-10-20-14/h2-10H,1H3,(H,22,24)(H,18,20,21)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168221
PNG
(US9669031, 50 N-[6-[(8-chloro-4′,4′-di...)
Show SMILES FC1(F)CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n21
Show InChI InChI=1S/C20H19ClF2N6O3/c21-11-7-12(26-13-8-14(25-9-24-13)27-16(30)10-1-2-10)18(32)29-15(11)17(31)28-20(29)5-3-19(22,23)4-6-20/h7-10H,1-6H2,(H,28,31)(H2,24,25,26,27,30)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168223
PNG
(US9669031, 52 N-[6-[[8-chloro-3-(3-fluorophenyl)-3...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)c1cccc(F)c1
Show InChI InChI=1S/C22H18ClFN6O3/c1-22(12-3-2-4-13(24)7-12)29-20(32)18-14(23)8-15(21(33)30(18)22)27-16-9-17(26-10-25-16)28-19(31)11-5-6-11/h2-4,7-11H,5-6H2,1H3,(H,29,32)(H2,25,26,27,28,31)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168225
PNG
(US9669031, 54 8-chloro-6-(pyrimidin-4-ylamino)spir...)
Show SMILES CC(C)(C)OC(=O)N1CCCC2(C1)NC(=O)c1c(Cl)cc(Nc3ccncn3)c(=O)n21
Show InChI InChI=1S/C20H23ClN6O4/c1-19(2,3)31-18(30)26-8-4-6-20(10-26)25-16(28)15-12(21)9-13(17(29)27(15)20)24-14-5-7-22-11-23-14/h5,7,9,11H,4,6,8,10H2,1-3H3,(H,25,28)(H,22,23,24)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168226
PNG
(US9669031, 55 8-chloro-3-methyl-6-(pyrimidin-4-yla...)
Show SMILES CC1(CC(F)(F)F)NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C14H11ClF3N5O2/c1-13(5-14(16,17)18)22-11(24)10-7(15)4-8(12(25)23(10)13)21-9-2-3-19-6-20-9/h2-4,6H,5H2,1H3,(H,22,24)(H,19,20,21)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168228
PNG
(US9669031, 56 N-(6-((8-chloro-1,5-dioxo-1,5-dihydr...)
Show SMILES CC(C)(C)OC(=O)N1CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n21
Show InChI InChI=1S/C24H28ClN7O5/c1-23(2,3)37-22(36)31-8-6-24(7-9-31)30-20(34)18-14(25)10-15(21(35)32(18)24)28-16-11-17(27-12-26-16)29-19(33)13-4-5-13/h10-13H,4-9H2,1-3H3,(H,30,34)(H2,26,27,28,29,33)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168231
PNG
(US9669031, 59 6-((6-((1-cyclopropyl-2,2,2-trifluor...)
Show SMILES CC1(NC(=O)c2ccc(Nc3cc(NC(C4CC4)C(F)(F)F)ncn3)c(=O)n12)C(F)(F)F
Show InChI InChI=1S/C18H16F6N6O2/c1-16(18(22,23)24)29-14(31)10-5-4-9(15(32)30(10)16)27-11-6-12(26-7-25-11)28-13(8-2-3-8)17(19,20)21/h4-8,13H,2-3H2,1H3,(H,29,31)(H2,25,26,27,28)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168233
PNG
(US9669031, 61 N-(6-((8-chloro-1,5-dioxo-1,2′...)
Show SMILES Clc1cc(Nc2cc(NC(=O)C3CC3)ncn2)c(=O)n2c1C(=O)NC21CCOCC1
Show InChI InChI=1S/C19H19ClN6O4/c20-11-7-12(23-13-8-14(22-9-21-13)24-16(27)10-1-2-10)18(29)26-15(11)17(28)25-19(26)3-5-30-6-4-19/h7-10H,1-6H2,(H,25,28)(H2,21,22,23,24,27)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168235
PNG
(US9669031, 63 8-chloro-2′,2′-dimethyl-...)
Show SMILES CC1(C)CCCC11NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C17H18ClN5O2/c1-16(2)5-3-6-17(16)22-14(24)13-10(18)8-11(15(25)23(13)17)21-12-4-7-19-9-20-12/h4,7-9H,3,5-6H2,1-2H3,(H,22,24)(H,19,20,21)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168250
PNG
(US9669031, 78 N-(6-((8′-chloro-2-fluoro-1...)
Show SMILES FC1CCCCC11NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12
Show InChI InChI=1S/C20H20ClFN6O3/c21-11-7-12(25-14-8-15(24-9-23-14)26-17(29)10-4-5-10)19(31)28-16(11)18(30)27-20(28)6-2-1-3-13(20)22/h7-10,13H,1-6H2,(H,27,30)(H2,23,24,25,26,29)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168250
PNG
(US9669031, 78 N-(6-((8′-chloro-2-fluoro-1...)
Show SMILES FC1CCCCC11NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12
Show InChI InChI=1S/C20H20ClFN6O3/c21-11-7-12(25-14-8-15(24-9-23-14)26-17(29)10-4-5-10)19(31)28-16(11)18(30)27-20(28)6-2-1-3-13(20)22/h7-10,13H,1-6H2,(H,27,30)(H2,23,24,25,26,29)
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US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168262
PNG
(US9669031, 90 8-chloro-3-methyl-3-(6-methyl-2-pyri...)
Show SMILES Cc1cccc(n1)C1(C)NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C18H15ClN6O2/c1-10-4-3-5-13(22-10)18(2)24-16(26)15-11(19)8-12(17(27)25(15)18)23-14-6-7-20-9-21-14/h3-9H,1-2H3,(H,24,26)(H,20,21,23)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168262
PNG
(US9669031, 90 8-chloro-3-methyl-3-(6-methyl-2-pyri...)
Show SMILES Cc1cccc(n1)C1(C)NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C18H15ClN6O2/c1-10-4-3-5-13(22-10)18(2)24-16(26)15-11(19)8-12(17(27)25(15)18)23-14-6-7-20-9-21-14/h3-9H,1-2H3,(H,24,26)(H,20,21,23)
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n/an/a<10n/an/an/an/an/a25



eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168264
PNG
(US9669031, 92 6-[(6-aminopyrimidin-4-yl)amino]-3-(...)
Show SMILES Cc1cc(Nc2cc(NC(=O)OC(C)(C)C)ncn2)c(=O)n2c1C(=O)NC2(C)c1cccc(Cl)c1
Show InChI InChI=1S/C24H25ClN6O4/c1-13-9-16(28-17-11-18(27-12-26-17)29-22(34)35-23(2,3)4)21(33)31-19(13)20(32)30-24(31,5)14-7-6-8-15(25)10-14/h6-12H,1-5H3,(H,30,32)(H2,26,27,28,29,34)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168268
PNG
(US9669031, 96 8-chloro-1′,1′-dimethyl-...)
Show SMILES CC1(C)CCCCC11NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C18H20ClN5O2/c1-17(2)6-3-4-7-18(17)23-15(25)14-11(19)9-12(16(26)24(14)18)22-13-5-8-20-10-21-13/h5,8-10H,3-4,6-7H2,1-2H3,(H,23,25)(H,20,21,22)
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n/an/a<10n/an/an/an/an/a25



eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168272
PNG
(US9669031, 100 8-chloro-6-((7-cyclopropylpyrido[4,...)
Show SMILES CC1(C)NC(=O)c2c(Cl)cc(Nc3ncnc4cc(ncc34)C3CC3)c(=O)n12
Show InChI InChI=1S/C19H17ClN6O2/c1-19(2)25-17(27)15-11(20)5-14(18(28)26(15)19)24-16-10-7-21-12(9-3-4-9)6-13(10)22-8-23-16/h5-9H,3-4H2,1-2H3,(H,25,27)(H,22,23,24)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168274
PNG
(US9669031, 102 6-((6-aminopyrimidin-4-yl)amino)-3,...)
Show SMILES Cc1cc(Nc2cc(NC(=O)C3CC3)ncn2)c(=O)n2c1C(=O)NC2(C)C
Show InChI InChI=1S/C18H20N6O3/c1-9-6-11(17(27)24-14(9)16(26)23-18(24,2)3)21-12-7-13(20-8-19-12)22-15(25)10-4-5-10/h6-8,10H,4-5H2,1-3H3,(H,23,26)(H2,19,20,21,22,25)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168278
PNG
(US9669031, 106 6-((6-aminopyrimidin-4-yl)amino)-8-...)
Show SMILES Cc1cc(Nc2cc(NC(=O)OC(C)(C)C)ncn2)c(=O)n2c1C(=O)NC21CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C26H35N7O6/c1-15-12-16(29-17-13-18(28-14-27-17)30-22(36)38-24(2,3)4)21(35)33-19(15)20(34)31-26(33)8-10-32(11-9-26)23(37)39-25(5,6)7/h12-14H,8-11H2,1-7H3,(H,31,34)(H2,27,28,29,30,36)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168285
PNG
(US9669031, 113 8-chloro-6-(pyrimidin-4-ylamino)spi...)
Show SMILES Clc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC21Cc2ccccc2C1=O
Show InChI InChI=1S/C19H12ClN5O3/c20-12-7-13(23-14-5-6-21-9-22-14)18(28)25-15(12)17(27)24-19(25)8-10-3-1-2-4-11(10)16(19)26/h1-7,9H,8H2,(H,24,27)(H,21,22,23)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168287
PNG
(US9669031, 115 8-chloro-6-[(5-chloropyrimidin-4-yl...)
Show SMILES Clc1cc(Nc2ncncc2Cl)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C16H15Cl2N5O2/c17-9-6-11(21-13-10(18)7-19-8-20-13)15(25)23-12(9)14(24)22-16(23)4-2-1-3-5-16/h6-8H,1-5H2,(H,22,24)(H,19,20,21)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM164608
PNG
(US9669031, 118 6-[(6-aminopyrimidin-4-yl)amino]-3-...)
Show SMILES CC1(NC(=O)c2ccc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)C1CCCC1
Show InChI InChI=1S/C21H24N6O3/c1-21(13-4-2-3-5-13)26-19(29)15-9-8-14(20(30)27(15)21)24-16-10-17(23-11-22-16)25-18(28)12-6-7-12/h8-13H,2-7H2,1H3,(H,26,29)(H2,22,23,24,25,28)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168302
PNG
(US9669031, 128 6-[(6-aminopyrimidin-4-yl)amino]-8-...)
Show SMILES CN1CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3cc(NC(=O)OC(C)(C)C)ncn3)c(=O)n21
Show InChI InChI=1S/C21H26ClN7O4/c1-20(2,3)33-19(32)26-15-10-14(23-11-24-15)25-13-9-12(22)16-17(30)27-21(29(16)18(13)31)5-7-28(4)8-6-21/h9-11H,5-8H2,1-4H3,(H,27,30)(H2,23,24,25,26,32)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168308
PNG
(US9669031, 142 4-((8′-chloro-1′,5̸...)
Show SMILES Clc1cc(Nc2ncncc2C#N)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C17H15ClN6O2/c18-11-6-12(22-14-10(7-19)8-20-9-21-14)16(26)24-13(11)15(25)23-17(24)4-2-1-3-5-17/h6,8-9H,1-5H2,(H,23,25)(H,20,21,22)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168301
PNG
(US9669031, 127 6′-((1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES Clc1cc(Nc2ncnc3[nH]ncc23)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C17H16ClN7O2/c18-10-6-11(22-13-9-7-21-24-14(9)20-8-19-13)16(27)25-12(10)15(26)23-17(25)4-2-1-3-5-17/h6-8H,1-5H2,(H,23,26)(H2,19,20,21,22,24)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168312
PNG
(US9669031, 151 8-chloro-3,3-dipropyl-6-(pyrimidin-...)
Show SMILES CCCC1(CCC)NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C17H20ClN5O2/c1-3-6-17(7-4-2)22-15(24)14-11(18)9-12(16(25)23(14)17)21-13-5-8-19-10-20-13/h5,8-10H,3-4,6-7H2,1-2H3,(H,22,24)(H,19,20,21)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168328
PNG
(US9669031, 162 8-chloro-4′-(methylamino)-6-(...)
Show SMILES CN(N1CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3ccncn3)c(=O)n21)C(=O)OC(C)(C)C
Show InChI InChI=1S/C21H26ClN7O4/c1-20(2,3)33-19(32)27(4)28-9-6-21(7-10-28)26-17(30)16-13(22)11-14(18(31)29(16)21)25-15-5-8-23-12-24-15/h5,8,11-12H,6-7,9-10H2,1-4H3,(H,26,30)(H,23,24,25)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168331
PNG
(US9669031, 164 8′-chloro-1′,5′-d...)
Show SMILES Clc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC21CCN(CC1)C#N
Show InChI InChI=1S/C16H14ClN7O2/c17-10-7-11(21-12-1-4-19-9-20-12)15(26)24-13(10)14(25)22-16(24)2-5-23(8-18)6-3-16/h1,4,7,9H,2-3,5-6H2,(H,22,25)(H,19,20,21)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168344
PNG
(US9669031, 193 6′-((6-amino-5-methylpyrimidi...)
Show SMILES Cc1c(Nc2cc(Cl)c3C(=O)NC4(CCCCC4)n3c2=O)ncnc1N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C
Show InChI InChI=1S/C27H35ClN6O6/c1-15-19(29-14-30-20(15)33(23(37)39-25(2,3)4)24(38)40-26(5,6)7)31-17-13-16(28)18-21(35)32-27(34(18)22(17)36)11-9-8-10-12-27/h13-14H,8-12H2,1-7H3,(H,32,35)(H,29,30,31)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168349
PNG
(US9669031, 198 8′-chloro-2′-cyclopenty...)
Show SMILES Clc1cc(Nc2ccncn2)c(=O)n2c1C(=O)N(C1CCCC1)C21CCCCC1
Show InChI InChI=1S/C21H24ClN5O2/c22-15-12-16(25-17-8-11-23-13-24-17)19(28)27-18(15)20(29)26(14-6-2-3-7-14)21(27)9-4-1-5-10-21/h8,11-14H,1-7,9-10H2,(H,23,24,25)
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eFFECTOR THERAPEUTICS, INC.

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Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM164263
PNG
(US9669031, 5 3-(3-fluorobenzyl)-3-methyl-6-(pyrimi...)
Show SMILES CC1(Cc2cccc(F)c2)NC(=O)c2ccc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C19H16FN5O2/c1-19(10-12-3-2-4-13(20)9-12)24-17(26)15-6-5-14(18(27)25(15)19)23-16-7-8-21-11-22-16/h2-9,11H,10H2,1H3,(H,24,26)(H,21,22,23)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM164267
PNG
(US9669031, 6 6′-(pyrimidin-4-ylamino)-1̸...)
Show SMILES O=C1NC2(CCCC2)n2c1ccc(Nc1ccncn1)c2=O
Show InChI InChI=1S/C15H15N5O2/c21-13-11-4-3-10(18-12-5-8-16-9-17-12)14(22)20(11)15(19-13)6-1-2-7-15/h3-5,8-9H,1-2,6-7H2,(H,19,21)(H,16,17,18)
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eFFECTOR THERAPEUTICS, INC.

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Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM164268
PNG
(US9669031, 7 3-methyl-6-(pyrimidin-4-ylamino)-3-(2...)
Show SMILES CC1(CC(F)(F)F)NC(=O)c2ccc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C14H12F3N5O2/c1-13(6-14(15,16)17)21-11(23)9-3-2-8(12(24)22(9)13)20-10-4-5-18-7-19-10/h2-5,7H,6H2,1H3,(H,21,23)(H,18,19,20)
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n/an/a 55n/an/an/an/an/a25



eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168201
PNG
(US9669031, 32 3,3-dimethyl-6-(7H-pyrrolo[2,3-d]pyr...)
Show SMILES CC1(C)NC(=O)c2ccc(-n3ccc4cncnc34)c(=O)n12
Show InChI InChI=1S/C15H13N5O2/c1-15(2)18-13(21)10-3-4-11(14(22)20(10)15)19-6-5-9-7-16-8-17-12(9)19/h3-8H,1-2H3,(H,18,21)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168202
PNG
(US9669031, 33 3-(3,5-dichlorophenyl)-3-methyl-6-(p...)
Show SMILES CC1(NC(=O)c2ccc(Nc3ccncn3)c(=O)n12)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C18H13Cl2N5O2/c1-18(10-6-11(19)8-12(20)7-10)24-16(26)14-3-2-13(17(27)25(14)18)23-15-4-5-21-9-22-15/h2-9H,1H3,(H,24,26)(H,21,22,23)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168203
PNG
(US9669031, 34 3-methyl-3-(pyridin-2-yl)-6-(pyrimid...)
Show SMILES CC1(NC(=O)c2ccc(Nc3ccncn3)c(=O)n12)c1ccccn1
Show InChI InChI=1S/C17H14N6O2/c1-17(13-4-2-3-8-19-13)22-15(24)12-6-5-11(16(25)23(12)17)21-14-7-9-18-10-20-14/h2-10H,1H3,(H,22,24)(H,18,20,21)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168204
PNG
(US9669031, 35 8-chloro-3-methyl-6-(pyrimidin-4-yla...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12)C(F)(F)F
Show InChI InChI=1S/C13H9ClF3N5O2/c1-12(13(15,16)17)21-10(23)9-6(14)4-7(11(24)22(9)12)20-8-2-3-18-5-19-8/h2-5H,1H3,(H,21,23)(H,18,19,20)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168206
PNG
(US9669031, 37 6-[(8-cyclopropyl-9H-purin-6-yl)amin...)
Show SMILES CC1(NC(=O)c2ccc(Nc3ncnc4[nH]c(cc34)C3CC3)c(=O)n12)C(F)(F)F
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168207
PNG
(US9669031, 38 N-[6-[(8-chloro-1,5-dioxo-spiro[2H-i...)
Show SMILES Clc1cc(Nc2cc(NC(=O)C3CC3)ncn2)c(=O)n2c1C(=O)NC21CCCC1
Show InChI InChI=1S/C19H19ClN6O3/c20-11-7-12(18(29)26-15(11)17(28)25-19(26)5-1-2-6-19)23-13-8-14(22-9-21-13)24-16(27)10-3-4-10/h7-10H,1-6H2,(H,25,28)(H2,21,22,23,24,27)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168208
PNG
(US9669031, 39 8′-chloro-6′-(pyrimidin-...)
Show SMILES Clc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC21CCCC1
Show InChI InChI=1S/C15H14ClN5O2/c16-9-7-10(19-11-3-6-17-8-18-11)14(23)21-12(9)13(22)20-15(21)4-1-2-5-15/h3,6-8H,1-2,4-5H2,(H,20,22)(H,17,18,19)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168208
PNG
(US9669031, 39 8′-chloro-6′-(pyrimidin-...)
Show SMILES Clc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC21CCCC1
Show InChI InChI=1S/C15H14ClN5O2/c16-9-7-10(19-11-3-6-17-8-18-11)14(23)21-12(9)13(22)20-15(21)4-1-2-5-15/h3,6-8H,1-2,4-5H2,(H,20,22)(H,17,18,19)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168212
PNG
(US9669031, 43 N-[6-[(8-chloro-3,3-dimethyl-1,5-dio...)
Show SMILES CC1(C)NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12
Show InChI InChI=1S/C17H17ClN6O3/c1-17(2)23-15(26)13-9(18)5-10(16(27)24(13)17)21-11-6-12(20-7-19-11)22-14(25)8-3-4-8/h5-8H,3-4H2,1-2H3,(H,23,26)(H2,19,20,21,22,25)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168214
PNG
(US9669031, 207 6′-((6-aminopyrimidin-4-yl)am...)
Show SMILES Clc1cc(Nc2cc(NC(=O)C3CC3)ncn2)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C20H21ClN6O3/c21-12-8-13(24-14-9-15(23-10-22-14)25-17(28)11-4-5-11)19(30)27-16(12)18(29)26-20(27)6-2-1-3-7-20/h8-11H,1-7H2,(H,26,29)(H2,22,23,24,25,28)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168215
PNG
(US9669031, 46 N-[6-[[8-chloro-3-methyl-1,5-dioxo-3...)
Show SMILES CC1(CC(F)(F)F)NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12
Show InChI InChI=1S/C18H16ClF3N6O3/c1-17(6-18(20,21)22)27-15(30)13-9(19)4-10(16(31)28(13)17)25-11-5-12(24-7-23-11)26-14(29)8-2-3-8/h4-5,7-8H,2-3,6H2,1H3,(H,27,30)(H2,23,24,25,26,29)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%