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Patent code US9669031

Compile Data Set for Download or QSAR

Found 313 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM164268
PNG
(US9669031, 7 3-methyl-6-(pyrimidin-4-ylamino)-3-(2...)
Show SMILES CC1(CC(F)(F)F)NC(=O)c2ccc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C14H12F3N5O2/c1-13(6-14(15,16)17)21-11(23)9-3-2-8(12(24)22(9)13)20-10-4-5-18-7-19-10/h2-5,7H,6H2,1H3,(H,21,23)(H,18,19,20)
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n/an/a 55n/an/an/an/an/a25



eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM164278
PNG
(US9669031, 14 3-methyl-6-(pyrimidin-4-ylamino)-3-(...)
Show SMILES CC1(NC(=O)c2ccc(Nc3ccncn3)c(=O)n12)C(F)(F)F
Show InChI InChI=1S/C13H10F3N5O2/c1-12(13(14,15)16)20-10(22)8-3-2-7(11(23)21(8)12)19-9-4-5-17-6-18-9/h2-6H,1H3,(H,20,22)(H,17,18,19)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM164590
PNG
(US9669031, 18 3-(3-chlorophenyl)-3-methyl-6-(pyrim...)
Show SMILES CC1(NC(=O)c2ccc(Nc3ccncn3)c(=O)n12)c1cccc(Cl)c1
Show InChI InChI=1S/C18H14ClN5O2/c1-18(11-3-2-4-12(19)9-11)23-16(25)14-6-5-13(17(26)24(14)18)22-15-7-8-20-10-21-15/h2-10H,1H3,(H,23,25)(H,20,21,22)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM164600
PNG
(US9669031, 21 N-[6-[(1,5-dioxospiro[2H-imidazo[1,5...)
Show SMILES O=C(Nc1cc(Nc2ccc3C(=O)NC4(CCCC4)n3c2=O)ncn1)C1CC1
Show InChI InChI=1S/C19H20N6O3/c26-16(11-3-4-11)23-15-9-14(20-10-21-15)22-12-5-6-13-17(27)24-19(7-1-2-8-19)25(13)18(12)28/h5-6,9-11H,1-4,7-8H2,(H,24,27)(H2,20,21,22,23,26)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM164609
PNG
(US9669031, 24 N-[6-[[3-methyl-1,5-dioxo-3-(trifluo...)
Show SMILES CC1(NC(=O)c2ccc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)C(F)(F)F
Show InChI InChI=1S/C17H15F3N6O3/c1-16(17(18,19)20)25-14(28)10-5-4-9(15(29)26(10)16)23-11-6-12(22-7-21-11)24-13(27)8-2-3-8/h4-8H,2-3H2,1H3,(H,25,28)(H2,21,22,23,24,27)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM164609
PNG
(US9669031, 24 N-[6-[[3-methyl-1,5-dioxo-3-(trifluo...)
Show SMILES CC1(NC(=O)c2ccc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)C(F)(F)F
Show InChI InChI=1S/C17H15F3N6O3/c1-16(17(18,19)20)25-14(28)10-5-4-9(15(29)26(10)16)23-11-6-12(22-7-21-11)24-13(27)8-2-3-8/h4-8H,2-3H2,1H3,(H,25,28)(H2,21,22,23,24,27)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168140
PNG
(US9669031, 30 N-[6-[[3-(3-fluorophenyl)-3-methyl-1...)
Show SMILES CC1(NC(=O)c2ccc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)c1cccc(F)c1
Show InChI InChI=1S/C22H19FN6O3/c1-22(13-3-2-4-14(23)9-13)28-20(31)16-8-7-15(21(32)29(16)22)26-17-10-18(25-11-24-17)27-19(30)12-5-6-12/h2-4,7-12H,5-6H2,1H3,(H,28,31)(H2,24,25,26,27,30)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168223
PNG
(US9669031, 52 N-[6-[[8-chloro-3-(3-fluorophenyl)-3...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)c1cccc(F)c1
Show InChI InChI=1S/C22H18ClFN6O3/c1-22(12-3-2-4-13(24)7-12)29-20(32)18-14(23)8-15(21(33)30(18)22)27-16-9-17(26-10-25-16)28-19(31)11-5-6-11/h2-4,7-11H,5-6H2,1H3,(H,29,32)(H2,25,26,27,28,31)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168226
PNG
(US9669031, 55 8-chloro-3-methyl-6-(pyrimidin-4-yla...)
Show SMILES CC1(CC(F)(F)F)NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C14H11ClF3N5O2/c1-13(5-14(16,17)18)22-11(24)10-7(15)4-8(12(25)23(10)13)21-9-2-3-19-6-20-9/h2-4,6H,5H2,1H3,(H,22,24)(H,19,20,21)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168230
PNG
(US9669031, 58 8-chloro-3-(3-chlorophenyl)-3-methyl...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12)c1cccc(Cl)c1
Show InChI InChI=1S/C18H13Cl2N5O2/c1-18(10-3-2-4-11(19)7-10)24-16(26)15-12(20)8-13(17(27)25(15)18)23-14-5-6-21-9-22-14/h2-9H,1H3,(H,24,26)(H,21,22,23)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168231
PNG
(US9669031, 59 6-((6-((1-cyclopropyl-2,2,2-trifluor...)
Show SMILES CC1(NC(=O)c2ccc(Nc3cc(NC(C4CC4)C(F)(F)F)ncn3)c(=O)n12)C(F)(F)F
Show InChI InChI=1S/C18H16F6N6O2/c1-16(18(22,23)24)29-14(31)10-5-4-9(15(32)30(10)16)27-11-6-12(26-7-25-11)28-13(8-2-3-8)17(19,20)21/h4-8,13H,2-3H2,1H3,(H,29,31)(H2,25,26,27,28)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168244
PNG
(US9669031, 72 8-chloro-3-methyl-3-(3-pyridyl)-6-(p...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12)c1cccnc1
Show InChI InChI=1S/C17H13ClN6O2/c1-17(10-3-2-5-19-8-10)23-15(25)14-11(18)7-12(16(26)24(14)17)22-13-4-6-20-9-21-13/h2-9H,1H3,(H,23,25)(H,20,21,22)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168249
PNG
(US9669031, 77 N-[6-[[8-chloro-3-methyl-1,5-dioxo-3...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)c1cccnc1
Show InChI InChI=1S/C21H18ClN7O3/c1-21(12-3-2-6-23-9-12)28-19(31)17-13(22)7-14(20(32)29(17)21)26-15-8-16(25-10-24-15)27-18(30)11-4-5-11/h2-3,6-11H,4-5H2,1H3,(H,28,31)(H2,24,25,26,27,30)
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eFFECTOR THERAPEUTICS, INC.

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Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168253
PNG
(US9669031, 81 8-methoxy-3,3-dimethyl-6-(pyrimidin-...)
Show SMILES COc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC2(C)C
Show InChI InChI=1S/C14H15N5O3/c1-14(2)18-12(20)11-9(22-3)6-8(13(21)19(11)14)17-10-4-5-15-7-16-10/h4-7H,1-3H3,(H,18,20)(H,15,16,17)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168266
PNG
(US9669031, 94 6-[(6-aminopyrimidin-4-yl)amino]-8-c...)
Show SMILES CC(C)(C)OC(=O)Nc1cc(Nc2cc(Cl)c3C(=O)NC4(CCCC4)n3c2=O)ncn1
Show InChI InChI=1S/C20H23ClN6O4/c1-19(2,3)31-18(30)25-14-9-13(22-10-23-14)24-12-8-11(21)15-16(28)26-20(6-4-5-7-20)27(15)17(12)29/h8-10H,4-7H2,1-3H3,(H,26,28)(H2,22,23,24,25,30)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168267
PNG
(US9669031, 95 N-[6-[(8-chloro-1,1′,5-trioxo-...)
Show SMILES Clc1cc(Nc2cc(NC(=O)C3CC3)ncn2)c(=O)n2c1C(=O)NC21CS(=O)C1
Show InChI InChI=1S/C17H15ClN6O4S/c18-9-3-10(16(27)24-13(9)15(26)23-17(24)5-29(28)6-17)21-11-4-12(20-7-19-11)22-14(25)8-1-2-8/h3-4,7-8H,1-2,5-6H2,(H,23,26)(H2,19,20,21,22,25)
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Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168269
PNG
(US9669031, 97 N-(6-((8-chloro-3-methyl-1,5-dioxo-3...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)c1ccccc1
Show InChI InChI=1S/C22H19ClN6O3/c1-22(13-5-3-2-4-6-13)28-20(31)18-14(23)9-15(21(32)29(18)22)26-16-10-17(25-11-24-16)27-19(30)12-7-8-12/h2-6,9-12H,7-8H2,1H3,(H,28,31)(H2,24,25,26,27,30)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168270
PNG
(US9669031, 98 6-[(6-aminopyrimidin-4-yl)amino]-8-m...)
Show SMILES Cc1cc(Nc2cc(NC(=O)C3CC3)ncn2)c(=O)n2c1C(=O)NC21CCCC1
Show InChI InChI=1S/C20H22N6O3/c1-11-8-13(19(29)26-16(11)18(28)25-20(26)6-2-3-7-20)23-14-9-15(22-10-21-14)24-17(27)12-4-5-12/h8-10,12H,2-7H2,1H3,(H,25,28)(H2,21,22,23,24,27)
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US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168275
PNG
(US9669031, 103 6-[(6-aminopyrimidin-4-yl)amino]-4&...)
Show SMILES Cc1cc(Nc2cc(NC(=O)OC(C)(C)C)ncn2)c(=O)n2c1C(=O)NC21CCC(F)(F)CC1
Show InChI InChI=1S/C22H26F2N6O4/c1-12-9-13(27-14-10-15(26-11-25-14)28-19(33)34-20(2,3)4)18(32)30-16(12)17(31)29-22(30)7-5-21(23,24)6-8-22/h9-11H,5-8H2,1-4H3,(H,29,31)(H2,25,26,27,28,33)
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US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168279
PNG
(US9669031, 107 6′-((6-aminopyrimidin-4-yl)am...)
Show SMILES Cc1cc(Nc2cc(NC(=O)OC(C)(C)C)ncn2)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C22H28N6O4/c1-13-10-14(19(30)28-17(13)18(29)27-22(28)8-6-5-7-9-22)25-15-11-16(24-12-23-15)26-20(31)32-21(2,3)4/h10-12H,5-9H2,1-4H3,(H,27,29)(H2,23,24,25,26,31)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168309
PNG
(US9669031, 143 8′-chloro-6′-((5-(1-met...)
Show SMILES Cn1cc(cn1)-c1cncnc1Nc1cc(Cl)c2C(=O)NC3(CCCCC3)n2c1=O
Show InChI InChI=1S/C20H20ClN7O2/c1-27-10-12(8-24-27)13-9-22-11-23-17(13)25-15-7-14(21)16-18(29)26-20(28(16)19(15)30)5-3-2-4-6-20/h7-11H,2-6H2,1H3,(H,26,29)(H,22,23,25)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168311
PNG
(US9669031, 146 8-chloro-6-(3H-triazolo[4,5-d]pyrim...)
Show SMILES CC(C)C(=O)N(COCC[Si](C)(C)C)c1ncnc2n(COCC[Si](C)(C)C)nnc12
Show InChI InChI=1S/C20H38N6O3Si2/c1-16(2)20(27)25(14-28-9-11-30(3,4)5)18-17-19(22-13-21-18)26(24-23-17)15-29-10-12-31(6,7)8/h13,16H,9-12,14-15H2,1-8H3
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168321
PNG
(US9669031, 157 8-chloro-6-(pyrimidin-4-ylamino)-1&...)
Show SMILES FC(F)(F)CN1CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3ccncn3)c(=O)n21
Show InChI InChI=1S/C17H16ClF3N6O2/c18-10-7-11(24-12-1-4-22-9-23-12)15(29)27-13(10)14(28)25-16(27)2-5-26(6-3-16)8-17(19,20)21/h1,4,7,9H,2-3,5-6,8H2,(H,25,28)(H,22,23,24)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168325
PNG
(US9669031, 160 2-(8-chloro-1,5-dioxo-6-(pyrimidin-...)
Show SMILES Clc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC21CCN(CC#N)CC1
Show InChI InChI=1S/C17H16ClN7O2/c18-11-9-12(22-13-1-5-20-10-21-13)16(27)25-14(11)15(26)23-17(25)2-6-24(7-3-17)8-4-19/h1,5,9-10H,2-3,6-8H2,(H,23,26)(H,20,21,22)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168330
PNG
(US9669031, 163 1′-acetyl-8-chloro-6-(pyrimid...)
Show SMILES CC(=O)N1CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3ccncn3)c(=O)n21
Show InChI InChI=1S/C17H17ClN6O3/c1-10(25)23-6-3-17(4-7-23)22-15(26)14-11(18)8-12(16(27)24(14)17)21-13-2-5-19-9-20-13/h2,5,8-9H,3-4,6-7H2,1H3,(H,22,26)(H,19,20,21)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168332
PNG
(US9669031, 165 8-chloro-3,3-dimethyl-6-(pyrido[3,4...)
Show SMILES CC1(C)NC(=O)c2c(Cl)cc(Nc3ncnc4cnccc34)c(=O)n12
Show InChI InChI=1S/C16H13ClN6O2/c1-16(2)22-14(24)12-9(17)5-10(15(25)23(12)16)21-13-8-3-4-18-6-11(8)19-7-20-13/h3-7H,1-2H3,(H,22,24)(H,19,20,21)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168338
PNG
(US9669031, 187 8-chloro-6-[(5-methoxypyrimidin-4-y...)
Show SMILES COc1cncnc1Nc1cc(Cl)c2C(=O)NC3(CCCCC3)n2c1=O
Show InChI InChI=1S/C17H18ClN5O3/c1-26-12-8-19-9-20-14(12)21-11-7-10(18)13-15(24)22-17(23(13)16(11)25)5-3-2-4-6-17/h7-9H,2-6H2,1H3,(H,22,24)(H,19,20,21)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168339
PNG
(US9669031, 188 6′-((6-amino-5-ethylpyrimidin...)
Show SMILES CCc1c(Nc2cc(Cl)c3C(=O)NC4(CCCCC4)n3c2=O)ncnc1N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C
Show InChI InChI=1S/C28H37ClN6O6/c1-8-16-20(30-15-31-21(16)34(24(38)40-26(2,3)4)25(39)41-27(5,6)7)32-18-14-17(29)19-22(36)33-28(35(19)23(18)37)12-10-9-11-13-28/h14-15H,8-13H2,1-7H3,(H,33,36)(H,30,31,32)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168340
PNG
(US9669031, 189 6′-((6-amino-5-isopropylpyrim...)
Show SMILES CC(C)c1c(Nc2cc(Cl)c3C(=O)NC4(CCCCC4)n3c2=O)ncnc1N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C
Show InChI InChI=1S/C29H39ClN6O6/c1-16(2)19-21(31-15-32-22(19)35(25(39)41-27(3,4)5)26(40)42-28(6,7)8)33-18-14-17(30)20-23(37)34-29(36(20)24(18)38)12-10-9-11-13-29/h14-16H,9-13H2,1-8H3,(H,34,37)(H,31,32,33)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168350
PNG
(US9669031, 200 6′-((6-aminopyrimidin-4-yl)(m...)
Show SMILES CN(c1cc(NC(=O)C2CC2)ncn1)c1cc(Cl)c2C(=O)NC3(CCCC3)n2c1=O
Show InChI InChI=1S/C20H21ClN6O3/c1-26(15-9-14(22-10-23-15)24-17(28)11-4-5-11)13-8-12(21)16-18(29)25-20(6-2-3-7-20)27(16)19(13)30/h8-11H,2-7H2,1H3,(H,25,29)(H,22,23,24,28)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168368
PNG
(US9669031, 220 6-((6-amino-5-methylpyrimidin-4-yl)...)
Show SMILES CN1CCC2(CC1)NC(=O)c1c(C)cc(Nc3ncnc(NC(=O)C4CC4)c3C)c(=O)n21
Show InChI InChI=1S/C22H27N7O3/c1-12-10-15(25-17-13(2)18(24-11-23-17)26-19(30)14-4-5-14)21(32)29-16(12)20(31)27-22(29)6-8-28(3)9-7-22/h10-11,14H,4-9H2,1-3H3,(H,27,31)(H2,23,24,25,26,30)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168369
PNG
(US9669031, 222 6′-((6-amino-5-methylpyrimidi...)
Show SMILES Cc1cc(Nc2ncnc(NC(=O)C3CC3)c2C)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C22H26N6O3/c1-12-10-15(21(31)28-16(12)20(30)27-22(28)8-4-3-5-9-22)25-17-13(2)18(24-11-23-17)26-19(29)14-6-7-14/h10-11,14H,3-9H2,1-2H3,(H,27,30)(H2,23,24,25,26,29)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168370
PNG
(US9669031, 223 6′-((6-amino-5-chloropyrimidi...)
Show SMILES Cc1cc(Nc2ncnc(N)c2Cl)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C17H19ClN6O2/c1-9-7-10(22-14-11(18)13(19)20-8-21-14)16(26)24-12(9)15(25)23-17(24)5-3-2-4-6-17/h7-8H,2-6H2,1H3,(H,23,25)(H3,19,20,21,22)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM164257
PNG
(US9669031, 3 3-(4-fluorobenzyl)-3-methyl-6-(pyrimi...)
Show SMILES CC1(Cc2ccc(F)cc2)NC(=O)c2ccc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C19H16FN5O2/c1-19(10-12-2-4-13(20)5-3-12)24-17(26)15-7-6-14(18(27)25(15)19)23-16-8-9-21-11-22-16/h2-9,11H,10H2,1H3,(H,24,26)(H,21,22,23)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM164263
PNG
(US9669031, 5 3-(3-fluorobenzyl)-3-methyl-6-(pyrimi...)
Show SMILES CC1(Cc2cccc(F)c2)NC(=O)c2ccc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C19H16FN5O2/c1-19(10-12-3-2-4-13(20)9-12)24-17(26)15-6-5-14(18(27)25(15)19)23-16-7-8-21-11-22-16/h2-9,11H,10H2,1H3,(H,24,26)(H,21,22,23)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM164273
PNG
(US9669031, 11 3-(4-fluorophenyl)-3-methyl-6-(pyrim...)
Show SMILES CC1(NC(=O)c2ccc(Nc3ccncn3)c(=O)n12)c1ccc(F)cc1
Show InChI InChI=1S/C18H14FN5O2/c1-18(11-2-4-12(19)5-3-11)23-16(25)14-7-6-13(17(26)24(14)18)22-15-8-9-20-10-21-15/h2-10H,1H3,(H,23,25)(H,20,21,22)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM164274
PNG
(US9669031, 12 3-(3-fluorophenyl)-3-methyl-6-(pyrim...)
Show SMILES CC1(NC(=O)c2ccc(Nc3ccncn3)c(=O)n12)c1cccc(F)c1
Show InChI InChI=1S/C18H14FN5O2/c1-18(11-3-2-4-12(19)9-11)23-16(25)14-6-5-13(17(26)24(14)18)22-15-7-8-20-10-21-15/h2-10H,1H3,(H,23,25)(H,20,21,22)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM164276
PNG
(US9669031, 13 3-(4-chlorophenyl)-3-methyl-6-(pyrim...)
Show SMILES CC1(NC(=O)c2ccc(Nc3ccncn3)c(=O)n12)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H14ClN5O2/c1-18(11-2-4-12(19)5-3-11)23-16(25)14-7-6-13(17(26)24(14)18)22-15-8-9-20-10-21-15/h2-10H,1H3,(H,23,25)(H,20,21,22)
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Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM164278
PNG
(US9669031, 14 3-methyl-6-(pyrimidin-4-ylamino)-3-(...)
Show SMILES CC1(NC(=O)c2ccc(Nc3ccncn3)c(=O)n12)C(F)(F)F
Show InChI InChI=1S/C13H10F3N5O2/c1-12(13(14,15)16)20-10(22)8-3-2-7(11(23)21(8)12)19-9-4-5-17-6-18-9/h2-6H,1H3,(H,20,22)(H,17,18,19)
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n/an/a 55n/an/an/an/an/a25



eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM164600
PNG
(US9669031, 21 N-[6-[(1,5-dioxospiro[2H-imidazo[1,5...)
Show SMILES O=C(Nc1cc(Nc2ccc3C(=O)NC4(CCCC4)n3c2=O)ncn1)C1CC1
Show InChI InChI=1S/C19H20N6O3/c26-16(11-3-4-11)23-15-9-14(20-10-21-15)22-12-5-6-13-17(27)24-19(7-1-2-8-19)25(13)18(12)28/h5-6,9-11H,1-4,7-8H2,(H,24,27)(H2,20,21,22,23,26)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168200
PNG
(US9669031, 31 6-[[6-[(E)-2-cyclopropylvinyl]pyrimi...)
Show SMILES CC1(NC(=O)c2ccc(Nc3cc(\C=C\C4CC4)ncn3)c(=O)n12)C(F)(F)F
Show InChI InChI=1S/C18H16F3N5O2/c1-17(18(19,20)21)25-15(27)13-7-6-12(16(28)26(13)17)24-14-8-11(22-9-23-14)5-4-10-2-3-10/h4-10H,2-3H2,1H3,(H,25,27)(H,22,23,24)/b5-4+
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168204
PNG
(US9669031, 35 8-chloro-3-methyl-6-(pyrimidin-4-yla...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12)C(F)(F)F
Show InChI InChI=1S/C13H9ClF3N5O2/c1-12(13(15,16)17)21-10(23)9-6(14)4-7(11(24)22(9)12)20-8-2-3-18-5-19-8/h2-5H,1H3,(H,21,23)(H,18,19,20)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168207
PNG
(US9669031, 38 N-[6-[(8-chloro-1,5-dioxo-spiro[2H-i...)
Show SMILES Clc1cc(Nc2cc(NC(=O)C3CC3)ncn2)c(=O)n2c1C(=O)NC21CCCC1
Show InChI InChI=1S/C19H19ClN6O3/c20-11-7-12(18(29)26-15(11)17(28)25-19(26)5-1-2-6-19)23-13-8-14(22-9-21-13)24-16(27)10-3-4-10/h7-10H,1-6H2,(H,25,28)(H2,21,22,23,24,27)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168208
PNG
(US9669031, 39 8′-chloro-6′-(pyrimidin-...)
Show SMILES Clc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC21CCCC1
Show InChI InChI=1S/C15H14ClN5O2/c16-9-7-10(19-11-3-6-17-8-18-11)14(23)21-12(9)13(22)20-15(21)4-1-2-5-15/h3,6-8H,1-2,4-5H2,(H,20,22)(H,17,18,19)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168210
PNG
(US9669031, 41 3-(2-aminoethyl)-3-methyl-6-(pyrimid...)
Show SMILES CC1(CCN2C(=O)c3ccccc3C2=O)NC(=O)c2ccc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C22H18N6O4/c1-22(9-11-27-19(30)13-4-2-3-5-14(13)20(27)31)26-18(29)16-7-6-15(21(32)28(16)22)25-17-8-10-23-12-24-17/h2-8,10,12H,9,11H2,1H3,(H,26,29)(H,23,24,25)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168213
PNG
(US9669031, 44 N-(6-((8′-chloro-1′,5...)
Show SMILES Clc1cc(Nc2cc(NC(=O)C3CC3)ncn2)c(=O)n2c1C(=O)NC21CCC1
Show InChI InChI=1S/C18H17ClN6O3/c19-10-6-11(17(28)25-14(10)16(27)24-18(25)4-1-5-18)22-12-7-13(21-8-20-12)23-15(26)9-2-3-9/h6-9H,1-5H2,(H,24,27)(H2,20,21,22,23,26)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168213
PNG
(US9669031, 44 N-(6-((8′-chloro-1′,5...)
Show SMILES Clc1cc(Nc2cc(NC(=O)C3CC3)ncn2)c(=O)n2c1C(=O)NC21CCC1
Show InChI InChI=1S/C18H17ClN6O3/c19-10-6-11(17(28)25-14(10)16(27)24-18(25)4-1-5-18)22-12-7-13(21-8-20-12)23-15(26)9-2-3-9/h6-9H,1-5H2,(H,24,27)(H2,20,21,22,23,26)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168222
PNG
(US9669031, 51 N-[6-[[8-chloro-3-(3-chlorophenyl)-3...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)c1cccc(Cl)c1
Show InChI InChI=1S/C22H18Cl2N6O3/c1-22(12-3-2-4-13(23)7-12)29-20(32)18-14(24)8-15(21(33)30(18)22)27-16-9-17(26-10-25-16)28-19(31)11-5-6-11/h2-4,7-11H,5-6H2,1H3,(H,29,32)(H2,25,26,27,28,31)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168225
PNG
(US9669031, 54 8-chloro-6-(pyrimidin-4-ylamino)spir...)
Show SMILES CC(C)(C)OC(=O)N1CCCC2(C1)NC(=O)c1c(Cl)cc(Nc3ccncn3)c(=O)n21
Show InChI InChI=1S/C20H23ClN6O4/c1-19(2,3)31-18(30)26-8-4-6-20(10-26)25-16(28)15-12(21)9-13(17(29)27(15)20)24-14-5-7-22-11-23-14/h5,7,9,11H,4,6,8,10H2,1-3H3,(H,25,28)(H,22,23,24)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168236
PNG
(US9669031, 64 8-chloro-6-(pyrimidin-4-ylamino)-2&#...)
Show SMILES Clc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC21CCOCC1
Show InChI InChI=1S/C15H14ClN5O3/c16-9-7-10(19-11-1-4-17-8-18-11)14(23)21-12(9)13(22)20-15(21)2-5-24-6-3-15/h1,4,7-8H,2-3,5-6H2,(H,20,22)(H,17,18,19)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%