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Patent code US9669031

Compile Data Set for Download or QSAR

Found 313 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM164263
PNG
(US9669031, 5 3-(3-fluorobenzyl)-3-methyl-6-(pyrimi...)
Show SMILES CC1(Cc2cccc(F)c2)NC(=O)c2ccc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C19H16FN5O2/c1-19(10-12-3-2-4-13(20)9-12)24-17(26)15-6-5-14(18(27)25(15)19)23-16-7-8-21-11-22-16/h2-9,11H,10H2,1H3,(H,24,26)(H,21,22,23)
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n/an/a>100n/an/an/an/an/a25



eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM164278
PNG
(US9669031, 14 3-methyl-6-(pyrimidin-4-ylamino)-3-(...)
Show SMILES CC1(NC(=O)c2ccc(Nc3ccncn3)c(=O)n12)C(F)(F)F
Show InChI InChI=1S/C13H10F3N5O2/c1-12(13(14,15)16)20-10(22)8-3-2-7(11(23)21(8)12)19-9-4-5-17-6-18-9/h2-6H,1H3,(H,20,22)(H,17,18,19)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM164599
PNG
(US9669031, 20 6-(pyrimidin-4-ylamino)-1H-spiro[imi...)
Show SMILES CC(C)(C)OC(=O)N1CCCC2(C1)NC(=O)c1ccc(Nc3ccncn3)c(=O)n21
Show InChI InChI=1S/C20H24N6O4/c1-19(2,3)30-18(29)25-10-4-8-20(11-25)24-16(27)14-6-5-13(17(28)26(14)20)23-15-7-9-21-12-22-15/h5-7,9,12H,4,8,10-11H2,1-3H3,(H,24,27)(H,21,22,23)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM164607
PNG
(US9669031, 22 N-(6-((3-methyl-1,5-dioxo-3-(2,2,2-t...)
Show SMILES CC1(CC(F)(F)F)NC(=O)c2ccc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12
Show InChI InChI=1S/C18H17F3N6O3/c1-17(7-18(19,20)21)26-15(29)11-5-4-10(16(30)27(11)17)24-12-6-13(23-8-22-12)25-14(28)9-2-3-9/h4-6,8-9H,2-3,7H2,1H3,(H,26,29)(H2,22,23,24,25,28)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM164609
PNG
(US9669031, 24 N-[6-[[3-methyl-1,5-dioxo-3-(trifluo...)
Show SMILES CC1(NC(=O)c2ccc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)C(F)(F)F
Show InChI InChI=1S/C17H15F3N6O3/c1-16(17(18,19)20)25-14(28)10-5-4-9(15(29)26(10)16)23-11-6-12(22-7-21-11)24-13(27)8-2-3-8/h4-8H,2-3H2,1H3,(H,25,28)(H2,21,22,23,24,27)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM164615
PNG
(US9669031, 27 3-(3,5-difluorophenyl)-3-methyl-6-(p...)
Show SMILES CC1(NC(=O)c2ccc(Nc3ccncn3)c(=O)n12)c1cc(F)cc(F)c1
Show InChI InChI=1S/C18H13F2N5O2/c1-18(10-6-11(19)8-12(20)7-10)24-16(26)14-3-2-13(17(27)25(14)18)23-15-4-5-21-9-22-15/h2-9H,1H3,(H,24,26)(H,21,22,23)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168207
PNG
(US9669031, 38 N-[6-[(8-chloro-1,5-dioxo-spiro[2H-i...)
Show SMILES Clc1cc(Nc2cc(NC(=O)C3CC3)ncn2)c(=O)n2c1C(=O)NC21CCCC1
Show InChI InChI=1S/C19H19ClN6O3/c20-11-7-12(18(29)26-15(11)17(28)25-19(26)5-1-2-6-19)23-13-8-14(22-9-21-13)24-16(27)10-3-4-10/h7-10H,1-6H2,(H,25,28)(H2,21,22,23,24,27)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168208
PNG
(US9669031, 39 8′-chloro-6′-(pyrimidin-...)
Show SMILES Clc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC21CCCC1
Show InChI InChI=1S/C15H14ClN5O2/c16-9-7-10(19-11-3-6-17-8-18-11)14(23)21-12(9)13(22)20-15(21)4-1-2-5-15/h3,6-8H,1-2,4-5H2,(H,20,22)(H,17,18,19)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168210
PNG
(US9669031, 41 3-(2-aminoethyl)-3-methyl-6-(pyrimid...)
Show SMILES CC1(CCN2C(=O)c3ccccc3C2=O)NC(=O)c2ccc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C22H18N6O4/c1-22(9-11-27-19(30)13-4-2-3-5-14(13)20(27)31)26-18(29)16-7-6-15(21(32)28(16)22)25-17-8-10-23-12-24-17/h2-8,10,12H,9,11H2,1H3,(H,26,29)(H,23,24,25)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168215
PNG
(US9669031, 46 N-[6-[[8-chloro-3-methyl-1,5-dioxo-3...)
Show SMILES CC1(CC(F)(F)F)NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12
Show InChI InChI=1S/C18H16ClF3N6O3/c1-17(6-18(20,21)22)27-15(30)13-9(19)4-10(16(31)28(13)17)25-11-5-12(24-7-23-11)26-14(29)8-2-3-8/h4-5,7-8H,2-3,6H2,1H3,(H,27,30)(H2,23,24,25,26,29)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168216
PNG
(US9669031, 181 3,3-dimethyl-1,5-dioxo-6-(pyrimidin...)
Show SMILES CC1(C)NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C13H12ClN5O2/c1-13(2)18-11(20)10-7(14)5-8(12(21)19(10)13)17-9-3-4-15-6-16-9/h3-6H,1-2H3,(H,18,20)(H,15,16,17)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168221
PNG
(US9669031, 50 N-[6-[(8-chloro-4′,4′-di...)
Show SMILES FC1(F)CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n21
Show InChI InChI=1S/C20H19ClF2N6O3/c21-11-7-12(26-13-8-14(25-9-24-13)27-16(30)10-1-2-10)18(32)29-15(11)17(31)28-20(29)5-3-19(22,23)4-6-20/h7-10H,1-6H2,(H,28,31)(H2,24,25,26,27,30)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168222
PNG
(US9669031, 51 N-[6-[[8-chloro-3-(3-chlorophenyl)-3...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)c1cccc(Cl)c1
Show InChI InChI=1S/C22H18Cl2N6O3/c1-22(12-3-2-4-13(23)7-12)29-20(32)18-14(24)8-15(21(33)30(18)22)27-16-9-17(26-10-25-16)28-19(31)11-5-6-11/h2-4,7-11H,5-6H2,1H3,(H,29,32)(H2,25,26,27,28,31)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168223
PNG
(US9669031, 52 N-[6-[[8-chloro-3-(3-fluorophenyl)-3...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)c1cccc(F)c1
Show InChI InChI=1S/C22H18ClFN6O3/c1-22(12-3-2-4-13(24)7-12)29-20(32)18-14(23)8-15(21(33)30(18)22)27-16-9-17(26-10-25-16)28-19(31)11-5-6-11/h2-4,7-11H,5-6H2,1H3,(H,29,32)(H2,25,26,27,28,31)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168225
PNG
(US9669031, 54 8-chloro-6-(pyrimidin-4-ylamino)spir...)
Show SMILES CC(C)(C)OC(=O)N1CCCC2(C1)NC(=O)c1c(Cl)cc(Nc3ccncn3)c(=O)n21
Show InChI InChI=1S/C20H23ClN6O4/c1-19(2,3)31-18(30)26-8-4-6-20(10-26)25-16(28)15-12(21)9-13(17(29)27(15)20)24-14-5-7-22-11-23-14/h5,7,9,11H,4,6,8,10H2,1-3H3,(H,25,28)(H,22,23,24)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168232
PNG
(US9669031, 60 N-(6-((8-chloro-1,5-dioxo-1,5-dihydr...)
Show SMILES CC(C)(C)OC(=O)N1CCCC2(C1)NC(=O)c1c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n21
Show InChI InChI=1S/C24H28ClN7O5/c1-23(2,3)37-22(36)31-8-4-7-24(11-31)30-20(34)18-14(25)9-15(21(35)32(18)24)28-16-10-17(27-12-26-16)29-19(33)13-5-6-13/h9-10,12-13H,4-8,11H2,1-3H3,(H,30,34)(H2,26,27,28,29,33)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168235
PNG
(US9669031, 63 8-chloro-2′,2′-dimethyl-...)
Show SMILES CC1(C)CCCC11NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C17H18ClN5O2/c1-16(2)5-3-6-17(16)22-14(24)13-10(18)8-11(15(25)23(13)17)21-12-4-7-19-9-20-12/h4,7-9H,3,5-6H2,1-2H3,(H,22,24)(H,19,20,21)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168238
PNG
(US9669031, 66 8-chloro-2′-fluoro-6-(pyrimidi...)
Show SMILES FC1CCCCC11NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C16H15ClFN5O2/c17-9-7-10(21-12-4-6-19-8-20-12)15(25)23-13(9)14(24)22-16(23)5-2-1-3-11(16)18/h4,6-8,11H,1-3,5H2,(H,22,24)(H,19,20,21)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168239
PNG
(US9669031, 67 3,3,8-trimethyl-6-(pyrimidin-4-ylami...)
Show SMILES Cc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC2(C)C
Show InChI InChI=1S/C14H15N5O2/c1-8-6-9(17-10-4-5-15-7-16-10)13(21)19-11(8)12(20)18-14(19,2)3/h4-7H,1-3H3,(H,18,20)(H,15,16,17)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168241
PNG
(US9669031, 69 8-fluoro-3,3-dimethyl-6-(pyrimidin-4...)
Show SMILES CC1(C)NC(=O)c2c(F)cc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C13H12FN5O2/c1-13(2)18-11(20)10-7(14)5-8(12(21)19(10)13)17-9-3-4-15-6-16-9/h3-6H,1-2H3,(H,18,20)(H,15,16,17)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168216
PNG
(US9669031, 181 3,3-dimethyl-1,5-dioxo-6-(pyrimidin...)
Show SMILES CC1(C)NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C13H12ClN5O2/c1-13(2)18-11(20)10-7(14)5-8(12(21)19(10)13)17-9-3-4-15-6-16-9/h3-6H,1-2H3,(H,18,20)(H,15,16,17)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168246
PNG
(US9669031, 74 8-chloro-3-methyl-3-(2-pyridyl)-6-(p...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12)c1ccccn1
Show InChI InChI=1S/C17H13ClN6O2/c1-17(12-4-2-3-6-20-12)23-15(25)14-10(18)8-11(16(26)24(14)17)22-13-5-7-19-9-21-13/h2-9H,1H3,(H,23,25)(H,19,21,22)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168249
PNG
(US9669031, 77 N-[6-[[8-chloro-3-methyl-1,5-dioxo-3...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)c1cccnc1
Show InChI InChI=1S/C21H18ClN7O3/c1-21(12-3-2-6-23-9-12)28-19(31)17-13(22)7-14(20(32)29(17)21)26-15-8-16(25-10-24-15)27-18(30)11-4-5-11/h2-3,6-11H,4-5H2,1H3,(H,28,31)(H2,24,25,26,27,30)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168253
PNG
(US9669031, 81 8-methoxy-3,3-dimethyl-6-(pyrimidin-...)
Show SMILES COc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC2(C)C
Show InChI InChI=1S/C14H15N5O3/c1-14(2)18-12(20)11-9(22-3)6-8(13(21)19(11)14)17-10-4-5-15-7-16-10/h4-7H,1-3H3,(H,18,20)(H,15,16,17)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168255
PNG
(US9669031, 83 N-(6-((8-chloro-3-methyl-1,5-dioxo-3...)
Show SMILES Cc1cccc(c1)C1(C)NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12
Show InChI InChI=1S/C23H21ClN6O3/c1-12-4-3-5-14(8-12)23(2)29-21(32)19-15(24)9-16(22(33)30(19)23)27-17-10-18(26-11-25-17)28-20(31)13-6-7-13/h3-5,8-11,13H,6-7H2,1-2H3,(H,29,32)(H2,25,26,27,28,31)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168212
PNG
(US9669031, 43 N-[6-[(8-chloro-3,3-dimethyl-1,5-dio...)
Show SMILES CC1(C)NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12
Show InChI InChI=1S/C17H17ClN6O3/c1-17(2)23-15(26)13-9(18)5-10(16(27)24(13)17)21-11-6-12(20-7-19-11)22-14(25)8-3-4-8/h5-8H,3-4H2,1-2H3,(H,23,26)(H2,19,20,21,22,25)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168263
PNG
(US9669031, 91 N-[6-[[8-chloro-3-(3-fluorophenyl)-1...)
Show SMILES Fc1cccc(c1)C1NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12
Show InChI InChI=1S/C21H16ClFN6O3/c22-13-7-14(26-15-8-16(25-9-24-15)27-19(30)10-4-5-10)21(32)29-17(13)20(31)28-18(29)11-2-1-3-12(23)6-11/h1-3,6-10,18H,4-5H2,(H,28,31)(H2,24,25,26,27,30)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168270
PNG
(US9669031, 98 6-[(6-aminopyrimidin-4-yl)amino]-8-m...)
Show SMILES Cc1cc(Nc2cc(NC(=O)C3CC3)ncn2)c(=O)n2c1C(=O)NC21CCCC1
Show InChI InChI=1S/C20H22N6O3/c1-11-8-13(19(29)26-16(11)18(28)25-20(26)6-2-3-7-20)23-14-9-15(22-10-21-14)24-17(27)12-4-5-12/h8-10,12H,2-7H2,1H3,(H,25,28)(H2,21,22,23,24,27)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168273
PNG
(US9669031, 101 6-((6-aminopyrimidin-4-yl)amino)-3-...)
Show SMILES Cc1cc(Nc2cc(NC(=O)OC(C)(C)C)ncn2)c(=O)n2c1C(=O)NC2(C)c1cccc(F)c1
Show InChI InChI=1S/C24H25FN6O4/c1-13-9-16(28-17-11-18(27-12-26-17)29-22(34)35-23(2,3)4)21(33)31-19(13)20(32)30-24(31,5)14-7-6-8-15(25)10-14/h6-12H,1-5H3,(H,30,32)(H2,26,27,28,29,34)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168278
PNG
(US9669031, 106 6-((6-aminopyrimidin-4-yl)amino)-8-...)
Show SMILES Cc1cc(Nc2cc(NC(=O)OC(C)(C)C)ncn2)c(=O)n2c1C(=O)NC21CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C26H35N7O6/c1-15-12-16(29-17-13-18(28-14-27-17)30-22(36)38-24(2,3)4)21(35)33-19(15)20(34)31-26(33)8-10-32(11-9-26)23(37)39-25(5,6)7/h12-14H,8-11H2,1-7H3,(H,31,34)(H2,27,28,29,30,36)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168282
PNG
(US9669031, 110 8-chloro-4′,4′-difluoro...)
Show SMILES FC1(F)CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3ccncn3)c(=O)n21
Show InChI InChI=1S/C16H14ClF2N5O2/c17-9-7-10(22-11-1-6-20-8-21-11)14(26)24-12(9)13(25)23-16(24)4-2-15(18,19)3-5-16/h1,6-8H,2-5H2,(H,23,25)(H,20,21,22)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168292
PNG
(US9669031, 120 8′-chloro-2,2-dimethyl-6̸...)
Show SMILES CC1(C)CCC11NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C16H16ClN5O2/c1-15(2)4-5-16(15)21-13(23)12-9(17)7-10(14(24)22(12)16)20-11-3-6-18-8-19-11/h3,6-8H,4-5H2,1-2H3,(H,21,23)(H,18,19,20)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168297
PNG
(US9669031, 124 8-chloro-3,3-dimethyl-6-(pyrido[4,3...)
Show SMILES CC1(C)NC(=O)c2c(Cl)cc(Nc3ncnc4ccncc34)c(=O)n12
Show InChI InChI=1S/C16H13ClN6O2/c1-16(2)22-14(24)12-9(17)5-11(15(25)23(12)16)21-13-8-6-18-4-3-10(8)19-7-20-13/h3-7H,1-2H3,(H,22,24)(H,19,20,21)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM168302
PNG
(US9669031, 128 6-[(6-aminopyrimidin-4-yl)amino]-8-...)
Show SMILES CN1CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3cc(NC(=O)OC(C)(C)C)ncn3)c(=O)n21
Show InChI InChI=1S/C21H26ClN7O4/c1-20(2,3)33-19(32)26-15-10-14(23-11-24-15)25-13-9-12(22)16-17(30)27-21(29(16)18(13)31)5-7-28(4)8-6-21/h9-11H,5-8H2,1-4H3,(H,27,30)(H2,23,24,25,26,32)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168303
PNG
(US9669031, 129 8-chloro-1′-methyl-6-(pyrimid...)
Show SMILES CN1CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3ccncn3)c(=O)n21
Show InChI InChI=1S/C16H17ClN6O2/c1-22-6-3-16(4-7-22)21-14(24)13-10(17)8-11(15(25)23(13)16)20-12-2-5-18-9-19-12/h2,5,8-9H,3-4,6-7H2,1H3,(H,21,24)(H,18,19,20)
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Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168306
PNG
(US9669031, 133 8′-chloro-6′-(pyrimidin...)
Show SMILES Clc1cc(Nc2ccncn2)c(=S)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C16H16ClN5OS/c17-10-8-11(20-12-4-7-18-9-19-12)15(24)22-13(10)14(23)21-16(22)5-2-1-3-6-16/h4,7-9H,1-3,5-6H2,(H,21,23)(H,18,19,20)
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Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168333
PNG
(US9669031, 169 6′-((6-amino-5-fluoropyrimidi...)
Show SMILES Fc1c(NC(=O)C2CC2)ncnc1Nc1cc(Cl)c2C(=O)NC3(CCCCC3)n2c1=O
Show InChI InChI=1S/C20H20ClFN6O3/c21-11-8-12(19(31)28-14(11)18(30)27-20(28)6-2-1-3-7-20)25-15-13(22)16(24-9-23-15)26-17(29)10-4-5-10/h8-10H,1-7H2,(H,27,30)(H2,23,24,25,26,29)
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Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168349
PNG
(US9669031, 198 8′-chloro-2′-cyclopenty...)
Show SMILES Clc1cc(Nc2ccncn2)c(=O)n2c1C(=O)N(C1CCCC1)C21CCCCC1
Show InChI InChI=1S/C21H24ClN5O2/c22-15-12-16(25-17-8-11-23-13-24-17)19(28)27-18(15)20(29)26(14-6-2-3-7-14)21(27)9-4-1-5-10-21/h8,11-14H,1-7,9-10H2,(H,23,24,25)
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eFFECTOR THERAPEUTICS, INC.

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Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168351
PNG
(US9669031, 201 6′-(pyrimidin-4-ylamino)-8...)
Show SMILES O=C1NC2(CCCCC2)n2c1c(cc(Nc1ccncn1)c2=O)C1CCOCC1
Show InChI InChI=1S/C21H25N5O3/c27-19-18-15(14-5-10-29-11-6-14)12-16(24-17-4-9-22-13-23-17)20(28)26(18)21(25-19)7-2-1-3-8-21/h4,9,12-14H,1-3,5-8,10-11H2,(H,25,27)(H,22,23,24)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168361
PNG
(US9669031, 213 5-((6-aminopyrimidin-4-yl)amino)-3-...)
Show SMILES CC(C)Cn1c(C(N)=O)c(Cl)cc(Nc2cc(N)ncn2)c1=O
Show InChI InChI=1S/C14H17ClN6O2/c1-7(2)5-21-12(13(17)22)8(15)3-9(14(21)23)20-11-4-10(16)18-6-19-11/h3-4,6-7H,5H2,1-2H3,(H2,17,22)(H3,16,18,19,20)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168373
PNG
(US9669031, 230 1′-(2,2-difluoroethyl)-6-((5-...)
Show SMILES COc1cncnc1Nc1cc(C)c2C(=O)NC3(CCN(CC(F)F)CC3)n2c1=O
Show InChI InChI=1S/C19H22F2N6O3/c1-11-7-12(24-16-13(30-2)8-22-10-23-16)18(29)27-15(11)17(28)25-19(27)3-5-26(6-4-19)9-14(20)21/h7-8,10,14H,3-6,9H2,1-2H3,(H,25,28)(H,22,23,24)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168370
PNG
(US9669031, 223 6′-((6-amino-5-chloropyrimidi...)
Show SMILES Cc1cc(Nc2ncnc(N)c2Cl)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C17H19ClN6O2/c1-9-7-10(22-14-11(18)13(19)20-8-21-14)16(26)24-12(9)15(25)23-17(24)5-3-2-4-6-17/h7-8H,2-6H2,1H3,(H,23,25)(H3,19,20,21,22)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM164267
PNG
(US9669031, 6 6′-(pyrimidin-4-ylamino)-1̸...)
Show SMILES O=C1NC2(CCCC2)n2c1ccc(Nc1ccncn1)c2=O
Show InChI InChI=1S/C15H15N5O2/c21-13-11-4-3-10(18-12-5-8-16-9-17-12)14(22)20(11)15(19-13)6-1-2-7-15/h3-5,8-9H,1-2,6-7H2,(H,19,21)(H,16,17,18)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM164270
PNG
(US9669031, 9 3-cyclopentyl-3-methyl-6-(pyrimidin-4...)
Show SMILES CC1(NC(=O)c2ccc(Nc3ccncn3)c(=O)n12)C1CCCC1
Show InChI InChI=1S/C17H19N5O2/c1-17(11-4-2-3-5-11)21-15(23)13-7-6-12(16(24)22(13)17)20-14-8-9-18-10-19-14/h6-11H,2-5H2,1H3,(H,21,23)(H,18,19,20)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM164271
PNG
(US9669031, 10 N-(6-((3,3-dimethyl-1,5-dioxo-1,2,3,...)
Show SMILES CC1(C)NC(=O)c2ccc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12
Show InChI InChI=1S/C17H18N6O3/c1-17(2)22-15(25)11-6-5-10(16(26)23(11)17)20-12-7-13(19-8-18-12)21-14(24)9-3-4-9/h5-9H,3-4H2,1-2H3,(H,22,25)(H2,18,19,20,21,24)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM164273
PNG
(US9669031, 11 3-(4-fluorophenyl)-3-methyl-6-(pyrim...)
Show SMILES CC1(NC(=O)c2ccc(Nc3ccncn3)c(=O)n12)c1ccc(F)cc1
Show InChI InChI=1S/C18H14FN5O2/c1-18(11-2-4-12(19)5-3-11)23-16(25)14-7-6-13(17(26)24(14)18)22-15-8-9-20-10-21-15/h2-10H,1H3,(H,23,25)(H,20,21,22)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM164276
PNG
(US9669031, 13 3-(4-chlorophenyl)-3-methyl-6-(pyrim...)
Show SMILES CC1(NC(=O)c2ccc(Nc3ccncn3)c(=O)n12)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H14ClN5O2/c1-18(11-2-4-12(19)5-3-11)23-16(25)14-7-6-13(17(26)24(14)18)22-15-8-9-20-10-21-15/h2-10H,1H3,(H,23,25)(H,20,21,22)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM164281
PNG
(US9669031, 17 3-methyl-6-(pyrimidin-4-ylamino)-3-(...)
Show SMILES CC1(NC(=O)c2ccc(Nc3ccncn3)c(=O)n12)c1cscn1
Show InChI InChI=1S/C15H12N6O2S/c1-15(11-6-24-8-18-11)20-13(22)10-3-2-9(14(23)21(10)15)19-12-4-5-16-7-17-12/h2-8H,1H3,(H,20,22)(H,16,17,19)
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US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM164607
PNG
(US9669031, 22 N-(6-((3-methyl-1,5-dioxo-3-(2,2,2-t...)
Show SMILES CC1(CC(F)(F)F)NC(=O)c2ccc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12
Show InChI InChI=1S/C18H17F3N6O3/c1-17(7-18(19,20)21)26-15(29)11-5-4-10(16(30)27(11)17)24-12-6-13(23-8-22-12)25-14(28)9-2-3-9/h4-6,8-9H,2-3,7H2,1H3,(H,26,29)(H2,22,23,24,25,28)
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eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM164608
PNG
(US9669031, 118 6-[(6-aminopyrimidin-4-yl)amino]-3-...)
Show SMILES CC1(NC(=O)c2ccc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)C1CCCC1
Show InChI InChI=1S/C21H24N6O3/c1-21(13-4-2-3-5-13)26-19(29)15-9-8-14(20(30)27(15)21)24-16-10-17(23-11-22-16)25-18(28)12-6-7-12/h8-13H,2-7H2,1H3,(H,26,29)(H2,22,23,24,25,28)
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US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%