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PubMed code 10072679

Compile data set for download or QSAR
Found 86 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074349
PNG
((2-Bromo-4-isopropyl-phenyl)-ethyl-[4-(1-ethyl-pro...)
Show SMILES CCC(CC)c1cc(C)nc(n1)N(CC)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C21H30BrN3/c1-7-16(8-2)19-12-15(6)23-21(24-19)25(9-3)20-11-10-17(14(4)5)13-18(20)22/h10-14,16H,7-9H2,1-6H3
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 2n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074354
PNG
(CHEMBL168131 | N,N-Diallyl-N'-(2-bromo-4-dimethyla...)
Show SMILES CCN(c1nc(C)nc(n1)N(CC=C)CC=C)c1ccc(cc1Br)N(C)C
Show InChI InChI=1S/C20H27BrN6/c1-7-12-26(13-8-2)19-22-15(4)23-20(24-19)27(9-3)18-11-10-16(25(5)6)14-17(18)21/h7-8,10-11,14H,1-2,9,12-13H2,3-6H3
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 3n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074404
PNG
(CHEMBL168844 | N-(2-Bromo-4-isopropyl-phenyl)-N-et...)
Show SMILES CCCN(CCC)c1nc(C)nc(n1)N(CC)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C21H32BrN5/c1-7-12-26(13-8-2)20-23-16(6)24-21(25-20)27(9-3)19-11-10-17(15(4)5)14-18(19)22/h10-11,14-15H,7-9,12-13H2,1-6H3
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 4n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074332
PNG
(CHEMBL167463 | N,N-Diallyl-N'-(2-bromo-4-trifluoro...)
Show SMILES CCN(c1nc(C)nc(n1)N(CC=C)CC=C)c1ccc(OC(F)(F)F)cc1Br
Show InChI InChI=1S/C19H21BrF3N5O/c1-5-10-27(11-6-2)17-24-13(4)25-18(26-17)28(7-3)16-9-8-14(12-15(16)20)29-19(21,22)23/h5-6,8-9,12H,1-2,7,10-11H2,3-4H3
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 4n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074391
PNG
(CHEMBL424555 | N,N-Diallyl-N'-(2-bromo-4-isopropyl...)
Show SMILES CCN(c1nc(C)nc(n1)N(CC=C)CC=C)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C21H28BrN5/c1-7-12-26(13-8-2)20-23-16(6)24-21(25-20)27(9-3)19-11-10-17(15(4)5)14-18(19)22/h7-8,10-11,14-15H,1-2,9,12-13H2,3-6H3
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 4n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074333
PNG
(CHEMBL353877 | N*2*-(2-Bromo-4-isopropyl-phenyl)-N...)
Show SMILES CCCN(C1CC1)c1cc(C)nc(n1)N(CC)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C22H31BrN4/c1-6-12-27(18-9-10-18)21-13-16(5)24-22(25-21)26(7-2)20-11-8-17(15(3)4)14-19(20)23/h8,11,13-15,18H,6-7,9-10,12H2,1-5H3
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 5n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074330
PNG
(3-({4-[(4-Dimethylamino-2-trifluoromethyl-phenyl)-...)
Show SMILES CCCN(CCC#N)c1nc(C)nc(n1)N(CC)c1ccc(cc1C(F)(F)F)N(C)C
Show InChI InChI=1S/C21H28F3N7/c1-6-12-30(13-8-11-25)19-26-15(3)27-20(28-19)31(7-2)18-10-9-16(29(4)5)14-17(18)21(22,23)24/h9-10,14H,6-8,12-13H2,1-5H3
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 5n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074397
PNG
(CHEMBL166388 | N-(2-Bromo-4-isopropyl-phenyl)-N'-b...)
Show SMILES CCCCN(CC)c1nc(C)nc(n1)N(CC)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C21H32BrN5/c1-7-10-13-26(8-2)20-23-16(6)24-21(25-20)27(9-3)19-12-11-17(15(4)5)14-18(19)22/h11-12,14-15H,7-10,13H2,1-6H3
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 5n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074399
PNG
(CHEMBL354367 | N-(2-Bromo-4-trifluoromethoxy-pheny...)
Show SMILES CCCCN(CC)c1nc(C)nc(n1)N(CC)c1ccc(OC(F)(F)F)cc1Br
Show InChI InChI=1S/C19H25BrF3N5O/c1-5-8-11-27(6-2)17-24-13(4)25-18(26-17)28(7-3)16-10-9-14(12-15(16)20)29-19(21,22)23/h9-10,12H,5-8,11H2,1-4H3
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 5n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074384
PNG
(CHEMBL167428 | N-Cyclopropylmethyl-N'-(4-dimethyla...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc(n1)N(CC)c1ccc(cc1C(F)(F)F)N(C)C
Show InChI InChI=1S/C22H31F3N6/c1-6-12-30(14-16-8-9-16)20-26-15(3)27-21(28-20)31(7-2)19-11-10-17(29(4)5)13-18(19)22(23,24)25/h10-11,13,16H,6-9,12,14H2,1-5H3
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 5n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074336
PNG
(1-{3-Bromo-4-[(4-diethylamino-6-methyl-pyrimidin-2...)
Show SMILES CCN(CC)c1cc(C)nc(n1)N(CC)c1ccc(cc1Br)C(C)=O
Show InChI InChI=1S/C19H25BrN4O/c1-6-23(7-2)18-11-13(4)21-19(22-18)24(8-3)17-10-9-15(14(5)25)12-16(17)20/h9-12H,6-8H2,1-5H3
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 5n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074338
PNG
(2-Bromo-N*1*-(4,6-dimethyl-pyrimidin-2-yl)-N*1*-et...)
Show SMILES CCN(c1nc(C)cc(C)n1)c1c(Br)cc(cc1OC)N(C)C
Show InChI InChI=1S/C17H23BrN4O/c1-7-22(17-19-11(2)8-12(3)20-17)16-14(18)9-13(21(4)5)10-15(16)23-6/h8-10H,7H2,1-6H3
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 5n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074375
PNG
(CHEMBL354395 | N,N-Bis-cyclopropylmethyl-N'-(4-dim...)
Show SMILES CCN(c1nc(C)nc(n1)N(CC1CC1)CC1CC1)c1ccc(cc1C(F)(F)F)N(C)C
Show InChI InChI=1S/C23H31F3N6/c1-5-32(20-11-10-18(30(3)4)12-19(20)23(24,25)26)22-28-15(2)27-21(29-22)31(13-16-6-7-16)14-17-8-9-17/h10-12,16-17H,5-9,13-14H2,1-4H3
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 5n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074401
PNG
(CHEMBL166345 | N-Allyl-N'-(2-bromo-4-isopropyl-phe...)
Show SMILES CCN(c1nc(C)nc(n1)N(CC=C)C1CC1)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C21H28BrN5/c1-6-12-27(17-9-10-17)21-24-15(5)23-20(25-21)26(7-2)19-11-8-16(14(3)4)13-18(19)22/h6,8,11,13-14,17H,1,7,9-10,12H2,2-5H3
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 5n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074339
PNG
(CHEMBL424538 | N-(2-Bromo-4-dimethylamino-phenyl)-...)
Show SMILES CCN(CC)c1nc(C)nc(n1)N(CC)c1ccc(cc1Br)N(C)C
Show InChI InChI=1S/C18H27BrN6/c1-7-24(8-2)17-20-13(4)21-18(22-17)25(9-3)16-11-10-14(23(5)6)12-15(16)19/h10-12H,7-9H2,1-6H3
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 6n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074347
PNG
((Butyl-{4-[(4-dimethylamino-2-trifluoromethyl-phen...)
Show SMILES CCCCN(CC#N)c1nc(C)nc(n1)N(CC)c1ccc(cc1C(F)(F)F)N(C)C
Show InChI InChI=1S/C21H28F3N7/c1-6-8-12-30(13-11-25)19-26-15(3)27-20(28-19)31(7-2)18-10-9-16(29(4)5)14-17(18)21(22,23)24/h9-10,14H,6-8,12-13H2,1-5H3
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 6n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074388
PNG
(CHEMBL168497 | N-(4-Dimethylamino-2-trifluoromethy...)
Show SMILES CCCN(CCC)c1nc(C)nc(n1)N(CC)c1ccc(cc1C(F)(F)F)N(C)C
Show InChI InChI=1S/C21H31F3N6/c1-7-12-29(13-8-2)19-25-15(4)26-20(27-19)30(9-3)18-11-10-16(28(5)6)14-17(18)21(22,23)24/h10-11,14H,7-9,12-13H2,1-6H3
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 6n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074381
PNG
(CHEMBL168169 | N-(4-Dimethylamino-2-methyl-phenyl)...)
Show SMILES CCCN(CCC)c1nc(C)nc(n1)N(CC)c1ccc(cc1C)N(C)C
Show InChI InChI=1S/C21H34N6/c1-8-13-26(14-9-2)20-22-17(5)23-21(24-20)27(10-3)19-12-11-18(25(6)7)15-16(19)4/h11-12,15H,8-10,13-14H2,1-7H3
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 7n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074335
PNG
(3-({4-[(4-Dimethylamino-2-methyl-phenyl)-ethyl-ami...)
Show SMILES CCCN(CCC#N)c1nc(C)nc(n1)N(CC)c1ccc(cc1C)N(C)C
Show InChI InChI=1S/C21H31N7/c1-7-13-27(14-9-12-22)20-23-17(4)24-21(25-20)28(8-2)19-11-10-18(26(5)6)15-16(19)3/h10-11,15H,7-9,13-14H2,1-6H3
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 7n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074394
PNG
(3-(Butyl-{4-[(4-dimethylamino-2-methyl-phenyl)-eth...)
Show SMILES CCCCN(CCC#N)c1nc(C)nc(n1)N(CC)c1ccc(cc1C)N(C)C
Show InChI InChI=1S/C22H33N7/c1-7-9-14-28(15-10-13-23)21-24-18(4)25-22(26-21)29(8-2)20-12-11-19(27(5)6)16-17(20)3/h11-12,16H,7-10,14-15H2,1-6H3
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 8n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074407
PNG
((Butyl-{4-[(4-dimethylamino-2-methyl-phenyl)-ethyl...)
Show SMILES CCCCN(CC#N)c1nc(C)nc(n1)N(CC)c1ccc(cc1C)N(C)C
Show InChI InChI=1S/C21H31N7/c1-7-9-13-27(14-12-22)20-23-17(4)24-21(25-20)28(8-2)19-11-10-18(26(5)6)15-16(19)3/h10-11,15H,7-9,13-14H2,1-6H3
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 8n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074368
PNG
(1-(3-Bromo-4-{[4-(butyl-ethyl-amino)-6-methyl-pyri...)
Show SMILES CCCCN(CC)c1cc(C)nc(n1)N(CC)c1ccc(cc1Br)C(C)=O
Show InChI InChI=1S/C21H29BrN4O/c1-6-9-12-25(7-2)20-13-15(4)23-21(24-20)26(8-3)19-11-10-17(16(5)27)14-18(19)22/h10-11,13-14H,6-9,12H2,1-5H3
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 8n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074393
PNG
(CHEMBL353973 | N*2*-(2-Bromo-4-iodo-phenyl)-N*2*,N...)
Show SMILES CCN(CC)c1cc(C)nc(n1)N(CC)c1ccc(I)cc1Br
Show InChI InChI=1S/C17H22BrIN4/c1-5-22(6-2)16-10-12(4)20-17(21-16)23(7-3)15-9-8-13(19)11-14(15)18/h8-11H,5-7H2,1-4H3
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 9n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074366
PNG
(CHEMBL10203 | N*2*-(2-Bromo-4-isopropyl-phenyl)-N*...)
Show SMILES CCCN(CCC)c1cc(C)nc(n1)N(CC)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C22H33BrN4/c1-7-12-26(13-8-2)21-14-17(6)24-22(25-21)27(9-3)20-11-10-18(16(4)5)15-19(20)23/h10-11,14-16H,7-9,12-13H2,1-6H3
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 9n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074383
PNG
(CHEMBL268993 | N*2*-(2-Bromo-4-isopropyl-phenyl)-N...)
Show SMILES CCCN(CC1CC1)c1cc(C)nc(n1)N(CC)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C23H33BrN4/c1-6-12-27(15-18-8-9-18)22-13-17(5)25-23(26-22)28(7-2)21-11-10-19(16(3)4)14-20(21)24/h10-11,13-14,16,18H,6-9,12,15H2,1-5H3
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 9n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074400
PNG
(CHEMBL167122 | N-(2-Bromo-4,6-dimethoxy-phenyl)-N,...)
Show SMILES CCN(CC)c1nc(C)nc(n1)N(CC)c1c(Br)cc(OC)cc1OC
Show InChI InChI=1S/C18H26BrN5O2/c1-7-23(8-2)17-20-12(4)21-18(22-17)24(9-3)16-14(19)10-13(25-5)11-15(16)26-6/h10-11H,7-9H2,1-6H3
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 10n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074360
PNG
(CHEMBL352378 | N*2*-(2-Chloro-4,6-dimethoxy-phenyl...)
Show SMILES CCN(CC)c1cc(C)nc(n1)N(CC)c1c(Cl)cc(OC)cc1OC
Show InChI InChI=1S/C19H27ClN4O2/c1-7-23(8-2)17-10-13(4)21-19(22-17)24(9-3)18-15(20)11-14(25-5)12-16(18)26-6/h10-12H,7-9H2,1-6H3
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 10n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074331
PNG
(CHEMBL167444 | N*2*-(2-Bromo-4-isopropyl-phenyl)-N...)
Show SMILES CCCN(CCOC)c1cc(C)nc(n1)N(CC)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C22H33BrN4O/c1-7-11-26(12-13-28-6)21-14-17(5)24-22(25-21)27(8-2)20-10-9-18(16(3)4)15-19(20)23/h9-10,14-16H,7-8,11-13H2,1-6H3
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 11n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074413
PNG
(CHEMBL169094 | N*2*-(4-Dimethylamino-2-trifluorome...)
Show SMILES CCN(CC)c1cc(C)nc(n1)N(CC)c1ccc(cc1C(F)(F)F)N(C)C
Show InChI InChI=1S/C20H28F3N5/c1-7-27(8-2)18-12-14(4)24-19(25-18)28(9-3)17-11-10-15(26(5)6)13-16(17)20(21,22)23/h10-13H,7-9H2,1-6H3
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 11n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074411
PNG
((2-Bromo-4,6-dimethoxy-phenyl)-(4,6-dimethyl-pyrim...)
Show SMILES CCN(c1nc(C)cc(C)n1)c1c(Br)cc(OC)cc1OC
Show InChI InChI=1S/C16H20BrN3O2/c1-6-20(16-18-10(2)7-11(3)19-16)15-13(17)8-12(21-4)9-14(15)22-5/h7-9H,6H2,1-5H3
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 12n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074403
PNG
(CHEMBL166835 | N-Butyl-N'-ethyl-N-(2-methoxy-ethyl...)
Show SMILES CCCCN(CCOC)c1nc(C)nc(n1)N(CC)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C22H35N5O/c1-8-10-11-26(12-13-28-7)21-23-19(6)24-22(25-21)27(9-2)20-17(4)14-16(3)15-18(20)5/h14-15H,8-13H2,1-7H3
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 13n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074363
PNG
(CHEMBL166235 | N*4*-Benzyl-N*2*-(2-bromo-4-isoprop...)
Show SMILES CCN(c1nc(C)cc(n1)N(CCOC)Cc1ccccc1)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C26H33BrN4O/c1-6-31(24-13-12-22(19(2)3)17-23(24)27)26-28-20(4)16-25(29-26)30(14-15-32-5)18-21-10-8-7-9-11-21/h7-13,16-17,19H,6,14-15,18H2,1-5H3
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 14n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074379
PNG
(CHEMBL165531 | N*2*-(2-Bromo-4-iodo-phenyl)-N*4*-b...)
Show SMILES CCCCN(CC)c1cc(C)nc(n1)N(CC)c1ccc(I)cc1Br
Show InChI InChI=1S/C19H26BrIN4/c1-5-8-11-24(6-2)18-12-14(4)22-19(23-18)25(7-3)17-10-9-15(21)13-16(17)20/h9-10,12-13H,5-8,11H2,1-4H3
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 14n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074342
PNG
(CHEMBL354584 | N*2*-(2,6-Dichloro-4-methoxy-phenyl...)
Show SMILES CCN(CC)c1cc(C)nc(n1)N(CC)c1c(Cl)cc(OC)cc1Cl
Show InChI InChI=1S/C18H24Cl2N4O/c1-6-23(7-2)16-9-12(4)21-18(22-16)24(8-3)17-14(19)10-13(25-5)11-15(17)20/h9-11H,6-8H2,1-5H3
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 15n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074344
PNG
(1-{3-Bromo-4-[(4-diethylamino-6-methyl-[1,3,5]tria...)
Show SMILES CCN(CC)c1nc(C)nc(n1)N(CC)c1ccc(cc1Br)C(C)=O
Show InChI InChI=1S/C18H24BrN5O/c1-6-23(7-2)17-20-13(5)21-18(22-17)24(8-3)16-10-9-14(12(4)25)11-15(16)19/h9-11H,6-8H2,1-5H3
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 17n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074359
PNG
(CHEMBL354791 | N*4*-Benzyl-N*2*-(2-bromo-4-isoprop...)
Show SMILES CCN(Cc1ccccc1)c1cc(C)nc(n1)N(CC)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C25H31BrN4/c1-6-29(17-20-11-9-8-10-12-20)24-15-19(5)27-25(28-24)30(7-2)23-14-13-21(18(3)4)16-22(23)26/h8-16,18H,6-7,17H2,1-5H3
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 17n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074374
PNG
(CHEMBL355055 | N-(2-Bromo-4-isopropyl-phenyl)-N-et...)
Show SMILES CCN(c1nc(C)nc(n1)N(CCOC)CCOC)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C21H32BrN5O2/c1-7-27(19-9-8-17(15(2)3)14-18(19)22)21-24-16(4)23-20(25-21)26(10-12-28-5)11-13-29-6/h8-9,14-15H,7,10-13H2,1-6H3
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 18n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074364
PNG
(CHEMBL350356 | N*2*-(2-Bromo-4-isopropyl-phenyl)-N...)
Show SMILES CCCCN(CC)c1cc(C)nc(n1)N(CC)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C22H33BrN4/c1-7-10-13-26(8-2)21-14-17(6)24-22(25-21)27(9-3)20-12-11-18(16(4)5)15-19(20)23/h11-12,14-16H,7-10,13H2,1-6H3
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 19n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074356
PNG
(CHEMBL168360 | N*1*-(4,6-Dimethyl-pyrimidin-2-yl)-...)
Show SMILES CCN(c1nc(C)cc(C)n1)c1ccc(cc1SC)N(C)C
Show InChI InChI=1S/C17H24N4S/c1-7-21(17-18-12(2)10-13(3)19-17)15-9-8-14(20(4)5)11-16(15)22-6/h8-11H,7H2,1-6H3
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 20n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074378
PNG
(CHEMBL165991 | N-(4-Dimethylamino-2-trifluoromethy...)
Show SMILES CCN(CC)c1nc(C)nc(n1)N(CC)c1ccc(cc1C(F)(F)F)N(C)C
Show InChI InChI=1S/C19H27F3N6/c1-7-27(8-2)17-23-13(4)24-18(25-17)28(9-3)16-11-10-14(26(5)6)12-15(16)19(20,21)22/h10-12H,7-9H2,1-6H3
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 20n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074387
PNG
(CHEMBL166890 | N*2*-(2-Bromo-4-isopropyl-phenyl)-N...)
Show SMILES CCN(CC)c1cc(C)nc(n1)N(CC)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C20H29BrN4/c1-7-24(8-2)19-12-15(6)22-20(23-19)25(9-3)18-11-10-16(14(4)5)13-17(18)21/h10-14H,7-9H2,1-6H3
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 22n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074372
PNG
((2-Bromo-4-isopropyl-phenyl)-ethyl-(4-methyl-6-mor...)
Show SMILES CCN(c1nc(C)cc(n1)N1CCOCC1)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C20H27BrN4O/c1-5-25(18-7-6-16(14(2)3)13-17(18)21)20-22-15(4)12-19(23-20)24-8-10-26-11-9-24/h6-7,12-14H,5,8-11H2,1-4H3
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 22n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074414
PNG
(CHEMBL167737 | N*2*-(2-Bromo-4-isopropyl-phenyl)-N...)
Show SMILES CCN(CCOC)c1cc(C)nc(n1)N(CC)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C21H31BrN4O/c1-7-25(11-12-27-6)20-13-16(5)23-21(24-20)26(8-2)19-10-9-17(15(3)4)14-18(19)22/h9-10,13-15H,7-8,11-12H2,1-6H3
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 22n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074387
PNG
(CHEMBL166890 | N*2*-(2-Bromo-4-isopropyl-phenyl)-N...)
Show SMILES CCN(CC)c1cc(C)nc(n1)N(CC)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C20H29BrN4/c1-7-24(8-2)19-12-15(6)22-20(23-19)25(9-3)18-11-10-16(14(4)5)13-17(18)21/h10-14H,7-9H2,1-6H3
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 22n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074367
PNG
(CHEMBL165473 | N-Butyl-N,N'-diethyl-6-methyl-N'-(2...)
Show SMILES CCCCN(CC)c1nc(C)nc(n1)N(CC)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C21H33N5/c1-8-11-12-25(9-2)20-22-18(7)23-21(24-20)26(10-3)19-16(5)13-15(4)14-17(19)6/h13-14H,8-12H2,1-7H3
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 23n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074362
PNG
(CHEMBL167195 | N*2*-(2-Bromo-4-methylsulfanyl-phen...)
Show SMILES CCN(CC)c1cc(C)nc(n1)N(CC)c1ccc(SC)cc1Br
Show InChI InChI=1S/C18H25BrN4S/c1-6-22(7-2)17-11-13(4)20-18(21-17)23(8-3)16-10-9-14(24-5)12-15(16)19/h9-12H,6-8H2,1-5H3
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 24n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074345
PNG
(CHEMBL167171 | N*2*-(2-Bromo-4-methanesulfonyl-phe...)
Show SMILES CCN(CC)c1cc(C)nc(n1)N(CC)c1ccc(cc1Br)S(C)(=O)=O
Show InChI InChI=1S/C18H25BrN4O2S/c1-6-22(7-2)17-11-13(4)20-18(21-17)23(8-3)16-10-9-14(12-15(16)19)26(5,24)25/h9-12H,6-8H2,1-5H3
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 24n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074369
PNG
(CHEMBL166238 | N*2*-(4-Bromo-2,6-dichloro-phenyl)-...)
Show SMILES CCN(CC)c1cc(C)nc(n1)N(CC)c1c(Cl)cc(Br)cc1Cl
Show InChI InChI=1S/C17H21BrCl2N4/c1-5-23(6-2)15-8-11(4)21-17(22-15)24(7-3)16-13(19)9-12(18)10-14(16)20/h8-10H,5-7H2,1-4H3
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 24n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074385
PNG
(CHEMBL166807 | N-Cyclopropylmethyl-N'-ethyl-N-(2-m...)
Show SMILES CCN(c1nc(C)nc(n1)N(CCOC)CC1CC1)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C22H33N5O/c1-7-27(20-16(3)12-15(2)13-17(20)4)22-24-18(5)23-21(25-22)26(10-11-28-6)14-19-8-9-19/h12-13,19H,7-11,14H2,1-6H3
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 25n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074410
PNG
(CHEMBL354859 | N*2*-(2-Bromo-4-isopropyl-phenyl)-N...)
Show SMILES CCN(c1nc(C)cc(n1)N(CCOC)CCOC)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C22H33BrN4O2/c1-7-27(20-9-8-18(16(2)3)15-19(20)23)22-24-17(4)14-21(25-22)26(10-12-28-5)11-13-29-6/h8-9,14-16H,7,10-13H2,1-6H3
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 25n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074337
PNG
(CHEMBL165873 | N*2*-(2-Bromo-4-isopropyl-6-methyls...)
Show SMILES CCN(CC)c1cc(C)nc(n1)N(CC)c1c(Br)cc(cc1SC)C(C)C
Show InChI InChI=1S/C21H31BrN4S/c1-8-25(9-2)19-11-15(6)23-21(24-19)26(10-3)20-17(22)12-16(14(4)5)13-18(20)27-7/h11-14H,8-10H2,1-7H3
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 26n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074392
PNG
((2-Bromo-4-isopropyl-6-methoxy-phenyl)-(4,6-dimeth...)
Show SMILES CCN(c1nc(C)cc(C)n1)c1c(Br)cc(cc1OC)C(C)C
Show InChI InChI=1S/C18H24BrN3O/c1-7-22(18-20-12(4)8-13(5)21-18)17-15(19)9-14(11(2)3)10-16(17)23-6/h8-11H,7H2,1-6H3
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 26n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074412
PNG
(CHEMBL165475 | N*2*-(2-Bromo-4-dimethylamino-pheny...)
Show SMILES CCN(CC)c1cc(C)nc(n1)N(CC)c1ccc(cc1Br)N(C)C
Show InChI InChI=1S/C19H28BrN5/c1-7-24(8-2)18-12-14(4)21-19(22-18)25(9-3)17-11-10-15(23(5)6)13-16(17)20/h10-13H,7-9H2,1-6H3
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 27n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074382
PNG
(CHEMBL353890 | N-(2-Bromo-4-isopropyl-phenyl)-N,N'...)
Show SMILES CCN(CC)c1nc(C)nc(n1)N(CC)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C19H28BrN5/c1-7-24(8-2)18-21-14(6)22-19(23-18)25(9-3)17-11-10-15(13(4)5)12-16(17)20/h10-13H,7-9H2,1-6H3
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 27n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074389
PNG
(1-{3-Bromo-4-[(4-diethylamino-6-methyl-pyrimidin-2...)
Show SMILES CCN(CC)c1cc(C)nc(n1)N(CC)c1c(Br)cc(cc1OC)C(C)=O
Show InChI InChI=1S/C20H27BrN4O2/c1-7-24(8-2)18-10-13(4)22-20(23-18)25(9-3)19-16(21)11-15(14(5)26)12-17(19)27-6/h10-12H,7-9H2,1-6H3
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 28n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074357
PNG
((2-Bromo-4-isopropyl-phenyl)-ethyl-(4-methyl-6-pip...)
Show SMILES CCN(c1nc(C)cc(n1)N1CCCCC1)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C21H29BrN4/c1-5-26(19-10-9-17(15(2)3)14-18(19)22)21-23-16(4)13-20(24-21)25-11-7-6-8-12-25/h9-10,13-15H,5-8,11-12H2,1-4H3
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 29n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074340
PNG
(CHEMBL166776 | N*2*-(2,4-Dibromo-6-methoxy-phenyl)...)
Show SMILES CCN(CC)c1cc(C)nc(n1)N(CC)c1c(Br)cc(Br)cc1OC
Show InChI InChI=1S/C18H24Br2N4O/c1-6-23(7-2)16-9-12(4)21-18(22-16)24(8-3)17-14(20)10-13(19)11-15(17)25-5/h9-11H,6-8H2,1-5H3
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 31n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074406
PNG
(CHEMBL167464 | N,N'-Diethyl-N-(2-methoxy-ethyl)-6-...)
Show SMILES CCN(CCOC)c1nc(C)nc(n1)N(CC)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C20H31N5O/c1-8-24(10-11-26-7)19-21-17(6)22-20(23-19)25(9-2)18-15(4)12-14(3)13-16(18)5/h12-13H,8-11H2,1-7H3
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 31n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074353
PNG
((2-Bromo-4,6-dimethoxy-phenyl)-ethyl-(4-methyl-6-m...)
Show SMILES CCN(c1nc(C)nc(n1)N1CCOCC1)c1c(Br)cc(OC)cc1OC
Show InChI InChI=1S/C18H24BrN5O3/c1-5-24(16-14(19)10-13(25-3)11-15(16)26-4)18-21-12(2)20-17(22-18)23-6-8-27-9-7-23/h10-11H,5-9H2,1-4H3
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 32n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074343
PNG
(CHEMBL166897 | N-Allyl-N'-(2-bromo-4-isopropyl-phe...)
Show SMILES CCN(c1nc(C)nc(NCC=C)n1)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C18H24BrN5/c1-6-10-20-17-21-13(5)22-18(23-17)24(7-2)16-9-8-14(12(3)4)11-15(16)19/h6,8-9,11-12H,1,7,10H2,2-5H3,(H,20,21,22,23)
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 33n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074373
PNG
((2-Bromo-4-methoxy-phenyl)-(4,6-dimethyl-pyrimidin...)
Show SMILES CCN(c1nc(C)cc(C)n1)c1ccc(OC)cc1Br
Show InChI InChI=1S/C15H18BrN3O/c1-5-19(15-17-10(2)8-11(3)18-15)14-7-6-12(20-4)9-13(14)16/h6-9H,5H2,1-4H3
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 35n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074380
PNG
((4,6-Dimethyl-pyrimidin-2-yl)-ethyl-(4-isopropyl-2...)
Show SMILES CCN(c1nc(C)cc(C)n1)c1ccc(cc1SC)C(C)C
Show InChI InChI=1S/C18H25N3S/c1-7-21(18-19-13(4)10-14(5)20-18)16-9-8-15(12(2)3)11-17(16)22-6/h8-12H,7H2,1-6H3
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 36n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50074351
PNG
((4,6-Dimethyl-pyrimidin-2-yl)-ethyl-(2-iodo-4-isop...)
Show SMILES CCN(c1nc(C)cc(C)n1)c1ccc(cc1I)C(C)C
Show InChI InChI=1S/C17H22IN3/c1-6-21(17-19-12(4)9-13(5)20-17)16-8-7-14(11(2)3)10-15(16)18/h7-11H,6H2,1-5H3
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 38n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity of the compound was measured on rat Corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074334
PNG
(CHEMBL443235 | N*2*-(2-Bromo-4-isopropyl-phenyl)-N...)
Show SMILES CCCCN(Cc1nnnn1C)c1cc(C)nc(n1)N(CC)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C23H33BrN8/c1-7-9-12-31(15-22-27-28-29-30(22)6)21-13-17(5)25-23(26-21)32(8-2)20-11-10-18(16(3)4)14-19(20)24/h10-11,13-14,16H,7-9,12,15H2,1-6H3
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 41n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074377
PNG
(CHEMBL165824 | N-(2-Bromo-4-isopropyl-phenyl)-N-et...)
Show SMILES CCC(CC)Nc1nc(C)nc(n1)N(CC)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C20H30BrN5/c1-7-16(8-2)24-19-22-14(6)23-20(25-19)26(9-3)18-11-10-15(13(4)5)12-17(18)21/h10-13,16H,7-9H2,1-6H3,(H,22,23,24,25)
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 41n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074361
PNG
(CHEMBL167738 | N*2*-(2-Bromo-4-isopropyl-phenyl)-N...)
Show SMILES CCC(CC)CNc1cc(C)nc(n1)N(CC)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C22H33BrN4/c1-7-17(8-2)14-24-21-12-16(6)25-22(26-21)27(9-3)20-11-10-18(15(4)5)13-19(20)23/h10-13,15,17H,7-9,14H2,1-6H3,(H,24,25,26)
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 44n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50074350
PNG
((2-Bromo-4-isopropyl-phenyl)-(4,6-dimethyl-pyrimid...)
Show SMILES CCN(c1nc(C)cc(C)n1)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C17H22BrN3/c1-6-21(17-19-12(4)9-13(5)20-17)16-8-7-14(11(2)3)10-15(16)18/h7-11H,6H2,1-5H3
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 46n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity of the compound was measured on rat Corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074365
PNG
(CHEMBL353296 | N*2*-(2-Bromo-4,6-dimethoxy-phenyl)...)
Show SMILES CCN(CC)c1cc(C)nc(n1)N(CC)c1c(Br)cc(OC)cc1OC
Show InChI InChI=1S/C19H27BrN4O2/c1-7-23(8-2)17-10-13(4)21-19(22-17)24(9-3)18-15(20)11-14(25-5)12-16(18)26-6/h10-12H,7-9H2,1-6H3
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 48n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074352
PNG
((2-Bromo-4-isopropyl-6-methylsulfanyl-phenyl)-(4,6...)
Show SMILES CCN(c1nc(C)cc(C)n1)c1c(Br)cc(cc1SC)C(C)C
Show InChI InChI=1S/C18H24BrN3S/c1-7-22(18-20-12(4)8-13(5)21-18)17-15(19)9-14(11(2)3)10-16(17)23-6/h8-11H,7H2,1-6H3
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 51n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074390
PNG
(CHEMBL166110 | N*1*-(4,6-Dimethyl-pyrimidin-2-yl)-...)
Show SMILES CCN(c1ccc(cc1C)N(C)C)c1nc(C)cc(C)n1
Show InChI InChI=1S/C17H24N4/c1-7-21(17-18-13(3)11-14(4)19-17)16-9-8-15(20(5)6)10-12(16)2/h8-11H,7H2,1-6H3
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 54n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074371
PNG
((4,6-Dimethyl-pyrimidin-2-yl)-ethyl-(4-methoxy-2-m...)
Show SMILES CCN(c1nc(C)cc(C)n1)c1ccc(OC)cc1SC
Show InChI InChI=1S/C16H21N3OS/c1-6-19(16-17-11(2)9-12(3)18-16)14-8-7-13(20-4)10-15(14)21-5/h7-10H,6H2,1-5H3
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 60n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074358
PNG
(CHEMBL166109 | N*1*-(4,6-Dimethyl-pyrimidin-2-yl)-...)
Show SMILES CCN(c1nc(C)cc(C)n1)c1ccc(cc1C(F)(F)F)N(C)C
Show InChI InChI=1S/C17H21F3N4/c1-6-24(16-21-11(2)9-12(3)22-16)15-8-7-13(23(4)5)10-14(15)17(18,19)20/h7-10H,6H2,1-5H3
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 68n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074402
PNG
(1-{4-[(4,6-Dimethyl-pyrimidin-2-yl)-ethyl-amino]-3...)
Show SMILES CCN(c1nc(C)cc(C)n1)c1ccc(cc1SC)C(C)=O
Show InChI InChI=1S/C17H21N3OS/c1-6-20(17-18-11(2)9-12(3)19-17)15-8-7-14(13(4)21)10-16(15)22-5/h7-10H,6H2,1-5H3
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 90n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50074408
PNG
((2-Bromo-4-isopropyl-phenyl)-(4,6-dimethyl-pyrimid...)
Show SMILES CC(C)c1ccc(N(C)c2nc(C)cc(C)n2)c(Br)c1
Show InChI InChI=1S/C16H20BrN3/c1-10(2)13-6-7-15(14(17)9-13)20(5)16-18-11(3)8-12(4)19-16/h6-10H,1-5H3
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 96n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity of the compound was measured on rat Corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074346
PNG
((2-Bromo-4-butyl-phenyl)-(4,6-dimethyl-pyrimidin-2...)
Show SMILES CCCCc1ccc(N(CC)c2nc(C)cc(C)n2)c(Br)c1
Show InChI InChI=1S/C18H24BrN3/c1-5-7-8-15-9-10-17(16(19)12-15)22(6-2)18-20-13(3)11-14(4)21-18/h9-12H,5-8H2,1-4H3
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>100n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074370
PNG
((2-Bromo-4-isopropyl-phenyl)-(4,6-diethyl-pyrimidi...)
Show SMILES CCN(c1nc(CC)cc(CC)n1)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C19H26BrN3/c1-6-15-12-16(7-2)22-19(21-15)23(8-3)18-10-9-14(13(4)5)11-17(18)20/h9-13H,6-8H2,1-5H3
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>100n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074348
PNG
((2-Bromo-4-tert-butyl-phenyl)-(4,6-dimethyl-pyrimi...)
Show SMILES CCN(c1nc(C)cc(C)n1)c1ccc(cc1Br)C(C)(C)C
Show InChI InChI=1S/C18H24BrN3/c1-7-22(17-20-12(2)10-13(3)21-17)16-9-8-14(11-15(16)19)18(4,5)6/h8-11H,7H2,1-6H3
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>100n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50074398
PNG
((2-Bromo-4-ethyl-phenyl)-(4,6-dimethyl-pyrimidin-2...)
Show SMILES CCc1ccc(N(C)c2nc(C)cc(C)n2)c(Br)c1
Show InChI InChI=1S/C15H18BrN3/c1-5-12-6-7-14(13(16)9-12)19(4)15-17-10(2)8-11(3)18-15/h6-9H,5H2,1-4H3
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 187n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity of the compound was measured on rat Corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074386
PNG
(CHEMBL166734 | N*2*-(2-Bromo-4-isopropyl-phenyl)-N...)
Show SMILES CCCCN(Cc1nnn[nH]1)c1cc(C)nc(n1)N(CC)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C22H31BrN8/c1-6-8-11-30(14-20-26-28-29-27-20)21-12-16(5)24-22(25-21)31(7-2)19-10-9-17(15(3)4)13-18(19)23/h9-10,12-13,15H,6-8,11,14H2,1-5H3,(H,26,27,28,29)
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>1.00E+3n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074396
PNG
((2-Bromo-4-isopropyl-phenyl)-ethyl-(4-methyl-6-pip...)
Show SMILES CCN(c1nc(C)cc(n1)N1CCNCC1)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C20H28BrN5/c1-5-26(18-7-6-16(14(2)3)13-17(18)21)20-23-15(4)12-19(24-20)25-10-8-22-9-11-25/h6-7,12-14,22H,5,8-11H2,1-4H3
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>1.00E+3n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074355
PNG
((4,6-Dimethyl-pyrimidin-2-yl)-ethyl-(4-isopropyl-p...)
Show SMILES CCN(c1ccc(cc1)C(C)C)c1nc(C)cc(C)n1
Show InChI InChI=1S/C17H23N3/c1-6-20(17-18-13(4)11-14(5)19-17)16-9-7-15(8-10-16)12(2)3/h7-12H,6H2,1-5H3
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>1.00E+3n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50074405
PNG
((2-Bromo-phenyl)-(4,6-dimethyl-pyrimidin-2-yl)-eth...)
Show SMILES CCN(c1nc(C)cc(C)n1)c1ccccc1Br
Show InChI InChI=1S/C14H16BrN3/c1-4-18(13-8-6-5-7-12(13)15)14-16-10(2)9-11(3)17-14/h5-9H,4H2,1-3H3
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>1.00E+3n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50074395
PNG
((2-Bromo-4-methyl-phenyl)-(4,6-dimethyl-pyrimidin-...)
Show SMILES CN(c1ccc(C)cc1Br)c1nc(C)cc(C)n1
Show InChI InChI=1S/C14H16BrN3/c1-9-5-6-13(12(15)7-9)18(4)14-16-10(2)8-11(3)17-14/h5-8H,1-4H3
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 1.10E+3n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity of the compound was measured on rat Corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50074341
PNG
((4,6-Dimethyl-pyrimidin-2-yl)-(4-iodo-phenyl)-meth...)
Show SMILES CN(c1ccc(I)cc1)c1nc(C)cc(C)n1
Show InChI InChI=1S/C13H14IN3/c1-9-8-10(2)16-13(15-9)17(3)12-6-4-11(14)5-7-12/h4-8H,1-3H3
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 3.30E+3n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity of the compound was measured on rat Corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50074409
PNG
((4,6-Dimethyl-pyrimidin-2-yl)-(2-iodo-phenyl)-meth...)
Show SMILES CN(c1ccccc1I)c1nc(C)cc(C)n1
Show InChI InChI=1S/C13H14IN3/c1-9-8-10(2)16-13(15-9)17(3)12-7-5-4-6-11(12)14/h4-8H,1-3H3
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 3.66E+3n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity of the compound was measured on rat Corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50074376
PNG
((2-Bromo-phenyl)-(4,6-dimethyl-pyrimidin-2-yl)-met...)
Show SMILES CN(c1ccccc1Br)c1nc(C)cc(C)n1
Show InChI InChI=1S/C13H14BrN3/c1-9-8-10(2)16-13(15-9)17(3)12-7-5-4-6-11(12)14/h4-8H,1-3H3
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 5.70E+3n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity of the compound was measured on rat Corticotropin releasing factor receptor 1

J Med Chem 42: 805-18 (1999)


Article DOI: 10.1021/jm980222w
BindingDB Entry DOI: 10.7270/Q29S1Q63
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%